CN101821623A - 用于精子性别选择的材料和方法 - Google Patents
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Abstract
本发明提供用于分离例如精液样品中携带X染色体和Y染色体的精子的材料和方法。所述方法包括使精液样品与结合剂接触，所述结合剂例如为抗体，其特异性结合对X-染色体或Y-染色体特异性的抗原。还提供用于所述方法的试剂盒。
Description
发明领域
本申请涉及鉴别携带X染色体或Y染色体的精子的方法。更具体地说，本申请涉及性别特异性抗原及其在这样的方法中的用途。
发明背景
鉴别并选择出雄性和雌性精子的能力对畜牧业具有极大的价值，在畜牧业中，存在一个既成的人工授精市场，在经济合作与发展组织(OECD)中，该市场每年超过20亿美元。这对乳品加工业尤其重要，在乳品加工业中，OECD重要市场中的大部分奶农通过人工授精使他们的母牛受孕。性控精液(sexed semen)给农场主提供了提高生产率和增加收入的机会。例如，应用性控精液对降低和/或消除小公奶牛的最低回报(minimal return)(相比于小母牛)具有显著影响。
目前，通过选择最佳的雄性种畜和使用人工授精(AI)使畜群受孕，实现了促成每头母牛产奶量显著增加的遗传性改善。然而，因为最佳的母牛可具有雄性或雌性后代，所以遗传改善的比率受限。性控精液允许由畜群中选择最佳的公牛和最佳的母牛从而使得畜群更新，由此增加遗传改善的比率。利用性控精液还可提供将高产奶牛的平均哺乳期长度延长至20-24个月的机会，因为可以为这些母牛提供的更新在一生中少于两头小牛。
在养猪业中，区分精子性别应通过减少生产的雄性数量消除对阉割的需要、提升饲养效率和增加动物的瘦肉含量。
目前唯一可用于分选携带X染色体或Y染色体的精液精子的方法是使用例如在美国专利号5,135,759、5,985,216、6,149,867和6,263,745中描述的流式细胞术。该方法利用由于DNA含量差异而产生的精子大小的微小尺寸差异，产生高度富集的具有X染色体或Y染色体的精子群(Johnson，Anim.Reprod.Sci.60-61：93-107(2000)；Johnson等人，Biol.Reprod.41：199-203(1989))。然而，该技术受限于流式细胞仪的使用，且太昂贵，不易于放大用于畜牧业中的常规性别选择。利用精子表面分子的性控精液，潜在地提供了成本低而有效且能放大的方法来实现该目标。
先前用于检测携带X和Y的精子上的表面差异的方法已经作了分析，包含众多策略，例如色谱学方法和免疫学方法(Blecher等人，Theriogenology 52：1309-1321(1999)；Hendriksen等人，Mol.Reprod.Dev.35：189-196(1993)；Howes等人，J.Reprod.Fertil.110：195-204(1997))。例如，授予Spaulding的美国专利号5,021,244描述了流式细胞术然后使用聚丙烯酰胺凝胶电泳(PAGE)分离与性别相关的膜蛋白，以及使用所述蛋白产生可用于提供富X精子或Y精子的精液样品的抗体。然而，随后使用Spaulding教导的方法的研究未能鉴别任何性别特异性精子，表明Spaulding的方案不太可能成功(Howes等人，Jnl.Reproduction Fertility 110：195-204(1997)；Hendriksen等人，Mol.Reproduction Develop.45：342-350(1996))。授予Blecher等人的美国公开专利申请号2003/0162238描述了性染色体特异性蛋白的分离，该蛋白被表征为X染色体特异性的，与牛精细胞的细胞膜结合，并具有约32kDa的分子量。
最近，分析技术的灵敏度已经随着引入二维PAGE或多维色谱分离继之以质谱分析而得到提升(Domon和Aebersold，Science312：212-217(2006))。然而，分析路径仍受困于两个主要问题：首先，使用该系统最难分析的一群蛋白是膜组分，例如整合蛋白，原因在于溶解性问题；其次，通过质谱进行的检测限于动态范围。如果存在其它高丰度的物质，则这种受限的动态范围就转换成检测低丰度分子的灵敏度降低。
迄今为止所描述的方法还没有成功发现对携带X或Y的精子特异性的抗原，提示不存在差异和/或就性质和/或丰度而言差异较小。因此，在本领域仍需要可有效用于鉴别和分离携带X染色体或Y染色体的精子的材料和方法。
发明概述
本发明提供鉴别和分离携带X染色体或Y染色体精子的有效的符合成本效益的非侵入性方法，以及用于这样的方法的组合物和试剂盒。本申请所公开的方法具有高特异性(即几乎不产生假阳性)和高灵敏度(即几乎不产生假阴性)。本申请公开的组合物包含特异性结合抗原的结合剂，所述抗原对携带X-染色体或Y-染色体的精子是特异性的(本申请称为X-染色体或Y-染色体特异性抗原)。例如，本申请公开的方法可用于人工授精，以增加后代成为所需性别的概率和/或增加后代携带产生所需性状的基因的概率。
一方面，本发明提供用于由精液中分离携带X-染色体或Y-染色体的精子的方法，以及通过这样的方法制备的精子。本申请公开的方法包括：(a)使精液与至少一种对X-染色体或Y-染色体特异性抗原具有特异性的结合剂接触一定时间，所述接触时间足以在结合剂和携带X-染色体或Y-染色体的精子之间形成缀合物；和(b)分离缀合物和未结合结合剂的精子。结合剂可以提供在固体表面上。在一个实施方案中，结合剂提供在磁珠(例如顺磁微球)表面上，并通过施加外部磁场将结合剂-精子缀合物和未结合的精子分离。在某些实施方案中，用于这些方法的结合剂对具有以下序列的抗原是特异性的：选自SEQ IDNO：1-21、43-89、138、140、142、144、146、148、150、152、154、156、158、160、162、164和183-201的氨基酸序列；与SEQ ID NO：1-21、43-89、138、140、142、144、146、148、150、152、154、156、158、160、162、164和183-201的序列具有至少85％、90％、95％、96％、97％、98％或99％同一性的序列；和由在严格杂交条件下与SEQID NO：22-42、90-136、137、139、141、143、145、147、149、151、153、155、157、159、161、163、165-182或202的序列杂交的多核苷酸编码的序列。
在某些实施方案中，在这样的方法中使用的至少一种结合剂为抗体(例如单克隆抗体)或其抗原结合片段，例如Fab或scFv。可以有效用于本发明公开方法中的结合剂的实例包括但不限于在以下表1中给出的结合剂。
另一方面，本发明提供包含对X-染色体或Y-染色体特异性抗原具有特异性的结合剂的组合物。在一个实施方案中，所述结合剂对具有选自SEQ ID NO：1-21、43-89、138、140、142、144、146、148、150、152、154、156、158、160、162、164和183-201的氨基酸序列的抗原及其变体是特异性。这样的结合剂可以用检测试剂标记，和/或如上所述，连接至磁珠，以有利于检测和/或分离生物样品如精液中的携带X-染色体或Y-染色体的精子。
又一方面，本发明提供用于所述公开方法的试剂盒，这样的试剂盒包含一个容器，该容器装有至少一种对本申请公开的X-染色体或Y-染色体特异性抗原具有特异性的结合剂。在某些实施方案中，这样的试剂盒包含磁珠，例如顺磁微球，其包被和/或结合有一种或多种所述结合剂。
又一方面，本发明提供用于鉴别对携带X-染色体或Y-染色体的精子具有特异性的基因和/或蛋白的方法，这样的方法包括如在以下的实施例中详述的生物信息学分析步骤和直接分析步骤的组合。这些方法还可以用于鉴别其它密切相关的细胞(包括但不限于正常细胞和癌细胞)之间的表面差异。
在相关方面，本发明提供用于富集精液样品中的携带X-染色体或Y-染色体的精子的方法，这样的方法包括使天然精液样品与本申请公开的至少一种结合剂接触，其中携带X-染色体或Y-染色体的精子与结合剂的结合有效降低精子的活动率和/或活力。在一个实施方案中，本申请公开的结合剂可以使用已知的方法缀合至细胞毒素，并且其用于破坏携带X-染色体或Y-染色体的精子。这样的方法可以用精液样品在体外进行，或者通过同时或序贯地将精液样品和结合剂导入雌性动物的阴道中在体内进行。在某些实施方案中，用于这类方法的结合剂特异性结合具有以下序列的抗原：选自SEQ ID NO：1-21、43-89、138、140、142、144、146、148、150、152、154、156、158、160、162、164和183-201的氨基酸序列；与SEQ ID NO：1-21、43-89、138、140、142、144、146、148、150、152、154、156、158、160、162、164和183-201的序列具有至少85％、90％、95％、96％、97％、98％或99％同一性的序列；和由在严格杂交条件下与SEQ ID NO：22-42、90-136、137、139、141、143、145、147、149、151、153、155、157、159、161、163、165-182或202的序列杂交的多核苷酸编码的序列。
参考以下更详细的描述和附图，本发明的上述特征和其它特征以及获得它们的方式将变得显而易见，且能更好地理解本发明。
附图简述
图1显示了已知的精子蛋白和本申请公开的候选X-染色体或Y-染色体特异性基因的直系同源物的RNA表达水平的对比。
图2是用于本研究的精子处理和结合测定的矩阵。
图3是用于本研究的SISCAPA技术的概述。
图4是用于本研究的iTRAQTM技术的概述。
发明详述
本申请的公开内容提供了对携带X-染色体或Y-染色体的精子具有特异性的抗原及其变体，特异性结合这样的抗原和/或其变体的结合剂，以及使用这样的结合剂检测和分离携带X-染色体和Y-染色体的精子的方法。本申请公开的牛X-染色体或Y-染色体特异性抗原的氨基酸序列提供于SEQ ID NO：1-21、138、140、142、144、146、148、150、152、154、156、158、160、162和164，相应的DNA序列分别提供于SEQ ID NO：22-42、137、139、141、143、145、147、149、151、153、155、157、159、161和163。本申请公开的人X-染色体或Y-染色体特异性抗原的氨基酸序列提供于SEQ ID NO：43-89，相应的DNA序列分别提供于SEQ ID NO：90-136。本申请公开的马X-染色体或Y-染色体特异性抗原的氨基酸序列提供于SEQ ID NO：183-200，相应的DNA序列分别提供于SEQ ID NO：165-182。
结合剂在本申请被定义为这样的物质：其结合本申请公开的X-染色体或Y-染色体特异性抗原或其变体之一的表位，但在相似的条件下不能可检测地结合不相关的多肽。满足这样的要求的任何物质都可以是结合剂。例如，结合剂可以为多肽(例如配体)、核糖体(有或没有肽组分)、RNA分子或小分子。结合剂特异性结合多肽的能力可以使用例如本领域众所周知的技术以ELISA测定来测定，和/或使用以下在实施例部分描述的测定来测定。在优选的实施方案中，结合剂为抗体、其功能性抗原结合片段、小链抗体可变结构域片段(scFv)、Fab片段、其重链可变结构域(VH)或其轻链可变结构域(VL)。可用于本申请公开的方法的结合剂包括但不限于在表1中标示出的结合剂。
表1
| 抗原SEQID NO： | 供应商 | 抗体名称 | 目录号 |
| 1 | SCBT* | PMCA3(N-18) | SC-22074 |
| 1 | SCBT* | PMCA3(C-15) | SC-22076 |
| 2 | SCBT* | BRS-3(N-14) | SC-33404 |
| 2 | SCBT* | BRS-3(K-19) | SC-33405 |
| 4，138 | 自制 | 抗FAM11A | N/A |
| 5 | 自制 | 抗VSIG1 | N/A |
| 6，140 | US Biological(Swampscott，MA) | CT1多克隆抗体 | C7911-10 |
| 7，142 | SCBT* | ATP7A(C-20) | sc-30858 |
| 7，142 | SCBT* | ATP7A(N-15) | sc-30856 |
| 7，142 | SCBT* | ATP7A(H-180) | sc-32900 |
| 8 | SCBT* | XK(C-17) | sc-50198 |
| 抗原SEQID NO： | 供应商 | 抗体名称 | 目录号 |
| 8 | SCBT* | XK(W-13) | sc-50201 |
| 8 | SCBT* | XK(Y-16) | sc-50202 |
| 8 | IBGRL** | CD 238抗体 | 9440 |
| 8 | IBGRL** | CD 238抗体 | 9441 |
| 抗原SEQID NO： | 供应商 | 抗体名称 | 目录号 |
| 8 | R&D Systems，Minneapolis，MN，USA | 抗人Kell抗体 | AF19 14 |
| 9 | SCBT* | NCAM-L1(5G3) | SC-33686 |
| 9 | SCBT* | NCAM-L1(I-18) | SC-31034 |
| 9 | SCBT* | NCAM-L1(N-14) | SC-31032 |
| 9 | SCBT* | NCAM-L1(UJ127.11) | SC-53386 |
| 9 | SCBT* | NCAM-L1(H-200) | SC-15326 |
| 9 | SCBT* | NCAM-L1(C-20) | SC-1508 |
| 10 | SCBT* | CXCR-3(49801.111) | SC-57076 |
| 10 | SCBT* | CXCR-3(C-20) | SC-6226 |
| 10 | SCBT* | CXCR-3(H-95) | SC-13951 |
| 10 | SCBT* | CXCR-3(CN-15) | SC-9900 |
| 12，148 | Everest Biotech Ltd.，Oxford，UK | 抗ATP6IP2/Renin报告抗体 | EB06118 |
| 13 | Everest Biotech Ltd.，Oxford，UK | 山羊抗PGRMC1/MPR抗体 | EB07207 |
| 15 | SCBT* | CKR-3(5E8) | SC-32777 |
| 15 | SCBT* | CKR-3(H-52) | SC-7897 |
| 抗原SEQID NO： | 供应商 | 抗体名称 | 目录号 |
| 15 | R&D Systems，Minneapolis，MN，USA | 抗人CCR3抗体 | MAB155 |
| 16，152 | Medical&BiologicalLaboratories Co.Ltd.，Woburn，MA，USA | CX3CR1 | D070-3 |
| 16，152 | SCBT* | CX3CR1(H-70) | SC-30030 |
| 16，152 | SCBT* | CX3CR 1(K-13) | SC-31561 |
| 16，152 | SCBT* | CX3CR1(T-20) | SC-20432 |
| 抗原SEQID NO： | 供应商 | 抗体名称 | 目录号 |
| 21，158 | Proteintech Group Inc.，Chicago，IL，USA | FMR1NB抗体 | 11069-2-AP |
| 45 | 自制 | 抗-EFBN1胞外结构域 | N/A |
*Santa Cruz Biotechnology Inc.，Santa Cruz，CA USA.
**国际血型参比实验室(International Blood Group ReferenceLaboratory)，Bristol，UK.
在替代的实施方案中，结合剂为蛋白质。例如，蛋白CCL11、CC124和CCL26可以用作SEQ ID NO：15的抗原的结合剂；CX3CL1和CXXXC趋化分子(fractaline)可以用作SEQ ID NO：16的抗原的结合剂；CxCL9、CxCL10和CxCL11可以用作SEQ ID NO：10的抗原的结合剂；而凝乳酶(rennin)可以用作SEQ ID NO：12的抗原的结合剂。
抗体的“抗原结合位点”或“抗原结合片段”是指参与抗原结合的抗体的一部分。抗原结合位点由重链(“H”)和轻链(“L”)的N-末端可变(“V”)区的氨基酸残基形成。在重链和轻链的V区中的3个高度不同的序列段被称为“超变区”，其被插入到称为“构架区”或“FR”的更保守的侧翼序列段之间。因此，术语“FR”是指天然存在于免疫球蛋白中的超变区之间并与其邻接的氨基酸序列。在抗体分子中，轻链的3个超变区和重链的3个超变区在三维空间中彼此相对排列，以形成抗原结合表面。抗原结合表面与结合抗原的三维表面互补，每条重链和轻链的3个超变区均被称为“互补决定区”或“CDR”。
抗体可以通过本领域一般技术人员已知的众多技术中的任一种制备。参见例如Harlow和Lane，Antibodies：A Laboratory Manual，ColdSpring Harbor Laboratory，1988。一般而言，抗体可以通过细胞培养技术产生，包括如本申请所述产生单克隆抗体，或者通过将抗体基因转染入合适的细菌或哺乳动物细胞宿主中以使得可以产生重组抗体。
单克隆抗体可以使用杂交瘤方法制备，例如Kohler和Milstein，Eur.J.Immunol.6：511-519，1976的技术及其改进技术。这些方法包括制备能够生产具有所需特异性的抗体的永生化细胞系。单克隆抗体还可以通过重组DNA方法制备，例如在美国专利4,816,567中描述的那些。可以使用常规程序分离并测序编码本申请公开的单克隆抗体的DNA。重组抗体、抗体片段及其融合体和聚合物可以在体外或在原核细胞(例如细菌)或真核细胞(例如酵母、昆虫或哺乳动物细胞)中表达，并根据需要使用众所周知的方法进一步纯化。
抗体还可以来源于重组抗体库，该重组抗体库基于已经由计算机模拟设计并由合成产生的多核苷酸编码的氨基酸序列。用于设计和获得计算机模拟产生的序列的方法是本领域已知的(Knappik等人，J.Mol.Biol.296：254：57-86，2000；Krebs等人，J.Immunol.Methods 254：67-84，2001；美国专利号6,300,064)。Rauchenberger等人(J.Biol.Chem.278：38194-38205，2003)已描述了可用于产生功能性Fab片段的人组合文库的构建方法。
可以使用本领域众所周知的技术对抗体进行消化，以产生其抗原结合片段。例如，蛋白水解酶木瓜蛋白酶优先切割IgG分子，以产生几个片段，其中两个(“F(ab)”片段)各自包含共价异二聚体，其包含完整的抗原结合位点。所述酶胃蛋白酶能够切割IgG分子，以提供几个片段，包括“F(ab′)2”片段，该片段包含两个抗原结合位点。“Fv”片段可以通过优先蛋白酶剪切IgM、IgG或IgA免疫球蛋白分子产生，但更通常使用本领域已知的重组技术获得。Fv片段包括非共价VH::VL异二聚体，其包含抗原结合位点，该位点保留了天然抗体分子的大部分抗原识别和结合能力(Inbar等人，Proc.Natl.Acad.Sci.USA69：2659-2662(1972)；Hochman等人，Biochem.15：2706-2710(1976)；和Ehrlich等人，Biochem.19：4091-4096(1980))。
在本领域中有众多的表达系统可用于生产抗体片段，包括Fab片段、scFv、VL和VH。例如，原核生物和真核生物源的表达系统可用于大规模生产抗体片段和抗体融合蛋白。特别有利的是允许将大量抗体片段分泌入培养基中的表达系统。已描述了用于大规模生产抗体片段和抗体融合蛋白的真核表达系统，其基于哺乳动物细胞、昆虫细胞、植物、转基因动物和低等真核生物。例如，可以在酵母发酵系统中实现符合成本效益且能大规模生产抗体片段。这些生物的大规模发酵在本领域是众所周知的，目前用于几种重组蛋白的原液生产。酵母和丝状真菌易于遗传修饰，而且目标蛋白可被分泌到培养基中。另外，某些产物符合GRAS(美国食品药物主管机构给予的检验标记，GenerallyRegarded as Safe)要求，因为它们不具有热原、毒素或病毒包涵体。
甲基营养酵母和其它酵母，如波氏假丝酵母(Candida boidinii)、多形汉逊酵母(Hansenula polymorpha)、甲醇毕赤酵母(Pichiamethanolica)和巴斯德毕赤氏酵母(Pichia pastoris)，是众所周知用于生产异源蛋白的系统。可以获得mg至g数量的高蛋白水平，并有可能成比例放大至工业应用的发酵。
巴斯德毕赤氏酵母(P.pastoris)系统用于几种工业规模的生产工艺。例如，已描述了毕赤酵母(Pichia)表达scFv片段以及重组抗体及其片段的应用。Ridder等人，Biotechnology 13：255-260(1995)；Anadrade等人，J.Biochem.(Tokyo)128：891-895(2000)；Pennell等人，Res.Immunol.149：599-603(1998)。在摇瓶培养中，可以实现250mg/L至超过1g/L scFv或VHH的水平(Eldin等人，J.Immunol.Methods201：67-75(1997)；Freyre等人，J.Biotechnol.76：157-163(2000))。
已针对酿酒酵母(Saccharomyces cerevisiae)、粟酒裂殖酵母(Schizosaccharomyces pombe)、耶罗维亚酵母(Yarrowia lipolytica)和乳酸克鲁维酵母(Kluyveromyces lactis)描述了用于scFv的相似表达系统。Horwitz等人，Proc.Natl.Acad.Sci.USA 85：8678-8682(1988)；Davis等人，Biotechnology 9：165-169(1991)；和Swennen等人，Microbiology148：41-50(2002)。丝状真菌，如木霉属和曲霉属，有能力分泌大量蛋白质。该特性可用于表达scFv和VHH。Radzio等人，Process-biochem.32：529-539(1997)；Punt等人，Trends Biotechnol.20：200-206(2002)；Verdoes等人，Appl.Microbiol.Biotechnol.43：195-205(1995)；Gouka等人，Appl.Microbiol.Biotechnol.47：1-11(1997)；Ward等人，Biotechnology 8：435-440(1990)；Durand等人，Enzyme Microb.Technol.6：341-346(1988)；Keranen等人，Curr.Opin.Biotechnol.6：534-537(1995)；Nevalainen等人，J.Biotechnol.37：193-200(1994)；Nyyssonen等人，Biotechnology 11：591-595(1993)；和Nyyssonen等人，国际专利公布号WO 92/01797。
在某些实施方案中，结合剂特异性结合本申请公开的X-染色体或Y-染色体特异性抗原的变体。本申请使用的术语“变体”包含与特异性鉴别的序列不同的核苷酸序列或氨基酸序列，其中一个或多个核苷酸或氨基酸残基被缺失、取代或添加。变体可以为天然等位基因变体，或者非天然变体。变体序列(多核苷酸或多肽)优选表现出与本申请公开的序列至少80％、85％、90％、95％、96％、97％、98％或99％的同一性。如下测定同一性百分率：比对如下所述要对比的两个序列，确定比对部分的相同残基数，将该数除以本发明的(查询)序列的残基总数，并将结果乘以100。
除了表现出所述水平的序列同一性之外，所公开的X-染色体或Y-染色体特异性抗原的变体自身优选对携带X-染色体或Y-染色体的精子具有特异性。
一般来说，变体序列与特异性鉴别的序列的差异仅在于保守取代、缺失或修饰。本申请使用的“保守取代”是这样的取代：其中一个氨基酸取代另一个具有相似特性的氨基酸，使得肽化学领域的技术人员能够预期多肽的二级结构和亲疏水性质未显著改变。一般而言，以下的氨基酸基团代表保守改变：(1)ala、pro、gly、glu、asp、gln、asn、ser、thr；(2)cys、ser、tyr、thr；(3)val、ile、leu、met、ala、phe；(4)lys、arg、his；和(5)phe、tyr、trp、his。变体还可以(或替代地)包含其它修饰，包括对多肽的抗原性质、二级结构和亲疏水性质影响最小的氨基酸的缺失或添加。例如，多肽可以缀合至蛋白N-末端的信号(或前导)序列，该序列共翻译或翻译后引导蛋白的转移。多肽还可以缀合至接头或其它序列，以易于合成、纯化或鉴别多肽(例如聚-His)，或者增强多肽与固体支持体的结合。例如，多肽可以缀合至免疫球蛋白Fc区。
可以比对多肽和多核苷酸序列，并可以使用可公开获得的计算机算法，针对另一个多核苷酸确定特定区域中的相同核苷酸的百分率。用于比对和鉴别多核苷酸序列的同一性的两个示例性算法是BLASTN和FASTA算法。可以使用BLASTP和算法检验多肽序列的比对和同一性。BLASTX和FASTX算法针对多肽序列比较所有读框中翻译的核苷酸查询序列。FASTA和FASTX算法描述于Pearson和Lipman，Proc.Natl.Acad.Sci.USA 85：2444-2448，1988；和Pearson，Methods in Enzymol.183：63-98，1990。FASTA软件包可得自维吉尼亚大学，Charlottesville，VA 22906-9025。FASTA算法设定为文件中所描述的并随算法一起分发的默认参数，可用于测定多核苷酸变体。随算法一起分发的FASTA和FASTX 2.0x版的自述文件描述了所述算法的应用，并描述了默认参数。
BLASTN软件可在NCBI匿名FTP服务器上获得，并可以由国家生物技术信息中心(NCBI)，国家医药图书馆，38A楼，8N805室，Bethesda，MD 20894获得。BLASTN算法2.0.6版[1998年9月10日]和2.0.11版[2000年1月20日]设定为在文件中描述的并随算法一起分发的默认参数，优选用于按照本发明测定变体。包括BLASTN在内的BLAST算法家族的应用描述于NCBI站点和出版物Altschul等人，“Gapped BLAST and PSI-BLAST：a new generation of protein databasesearch programs，”Nucleic Acids Res.25：3389-3402，1997。
用BLASTN、BLASTP、FASTA或相似算法产生的查询序列对一个或多个数据库序列的“命中结果”比对并鉴别序列的相似部分。按照相似度和序列重叠长度的顺序排列命中结果。针对数据库序列的命中结果，一般代表仅一部分查询序列序列长度内的重叠。
如下确定多核苷酸或多肽序列的同一性百分率：使用合适的算法，例如分别设定为默认参数的BLASTN或BLASTP，比对多核苷酸和多肽序列；鉴别比对部分内相同的核酸或氨基酸的数量；将相同的核酸或氨基酸的数目除以本发明的多核苷酸或多肽的核酸或氨基酸的总数；然后乘以100得到同一性百分率。
在替代的实施方案中，变体多肽由在严格条件下与所公开的多核苷酸杂交的多核苷酸序列编码。用于测定互补性的严格杂交条件包括低于约1M、更通常低于约500mM和优选低于约200mM的盐条件。杂交温度可以低至5℃，但一般高于约22℃，更优选高于约30℃，最优选高于约37℃。对于特异性杂交，较长的DNA片段可能需要较高的杂交温度。因为杂交严格性可能受其它因素如探针组成、存在有机溶剂和碱基错配程度的影响，所以参数组合比任一个单独参数的绝对度量更重要。示例性的“严格条件”是以6X SSC，0.2％SDS的溶液预洗涤；以65℃，6X SSC，0.2％SDS过夜杂交；接着各以1X SSC，0.1％SDS于65℃进行30分钟的两次洗涤，并各以0.2X SSC，0.1％SDS于65℃进行30分钟的两次洗涤。
分离并纯化本申请公开的所有结合剂和X-染色体或Y-染色体特异性抗原，如这些术语在本领域通常使用的那样。优选地，结合剂和抗原为至少约80％纯，更优选至少约90％纯，最优选至少约99％纯。
本申请公开的结合剂可以有效用于分离携带X-染色体和Y-染色体的精子，并因此可用于富集精液样品的确定雄性或雌性的精子。这些方法特别有利于制备用于哺乳动物人工授精的精子，所述哺乳动物包括但不限于牛、猪、绵羊、山羊、人、骆驼、马、鹿、羊驼、狗、猫、兔和啮齿动物。用于这类方法的精子可以为新鲜的一次射精液，或者可以预先冷冻并随后融化。
用于分离携带X-染色体和Y-染色体的精子的方法包括使精液样品与本申请公开的一种或多种结合剂接触一定时间，所述接触时间足以在精子和结合剂之间形成缀合物或复合物，然后分离缀合物和未结合的精子。在一个实施方案中，诸如顺磁微球的磁珠用结合剂包被，例如对Y-染色体特异性抗原具有特异性的结合剂，然后与在适宜容器中的精细胞悬浮液接触一定时间，所述接触时间足以允许形成结合剂和Y-染色体特异性抗原的缀合物，由此将携带Y-染色体的精子连接至所述珠。然后通过对容器施加磁场保留含有Y染色体的精子，而携带X染色体的精子易于通过由容器中除去上清液而被分离。使用磁珠分离和/或除去所需细胞类型的技术是本领域已知的，包括例如Olsaker等人(Animal Genetics，24：311-313(1993))以及美国专利号6,893,881和7,078,224所描述的那些。
要认识到的是，本申请公开的结合剂可用于本领域技术人员众所周知的其它用于分离需要细胞群的技术中。例如，首先可使天然精液样品接触本申请公开的结合剂，例如针对Y-染色体特异性抗原的抗体，然后接触特异性结合第一种抗体的第二种抗体，其中第二种抗体固定在基体(a substrate)上。携带Y-染色体的精子将结合第一种抗体，第一种抗体再结合第二种抗体因此最终结合到基体上，由此分离携带Y-染色体的精子和携带X-染色体的精子。可用于这些方法的基体是本领域众所周知的，包括例如硝酸纤维素膜。
还提供用于本申请公开的方法的试剂盒和/或装置。在一个实施方案中，这样的试剂盒和/或装置包括磁性粒子，例如顺磁微球，其用至少一种用于X-染色体或Y-染色体特异性抗原的结合剂包被和/或结合其上。所述试剂盒和/或装置可以以一次性抛弃型单元的形式提供，所述单元包含足以处理一次射精液的精子的结合剂。
包被的磁性粒子可用于使用已知方法分离携带X-染色体或Y-染色体的精子，所述方法例如Safarik和Safarikova(J.Chromatography，722：33-53(1999))所公开的那些。例如，当结合剂为小鼠单克隆抗体时，可以使用包含偶联可磁化的聚苯乙烯/氧化铁颗粒的A蛋白的珠，例如MagaBeadsTM A蛋白(Cortex Biochen.Inc.，San Leandro，CA，USA)。使用标准化学，例如用DMP交联剂(二甲基吡唑(dimethylprimelinidate)2 HCl)，使结合剂与珠交联。其它的结构域/区域可用于将结合剂连接至固定化支持体，例如磁珠。优化由磁珠释放精子的条件，以便避免伤害精子。例如，可以使用低pH和高甘氨酸浓度。
在某些实施方案中，所用的技术既由结合在支持体(例如磁珠)上的结合剂温和释放精子，又失活结合剂，由此阻止其重复作用。这可以通过例如在结合剂骨架的暴露部分提供蛋白酶识别位点(例如rhino3c蛋白酶)来实现。在将携带X-染色体或Y-染色体的精子结合到固定的结合剂并除去未结合的精子之后，使用蛋白酶切割高亲和力结合剂，由此破坏结合剂结合携带X-染色体或Y-染色体的精子的能力，并释放精子。在切割后，使用离心洗涤精子，以由精子分离分子组分。蛋白酶识别位点可以与二硫键或工程改造的金属离子结合位点(例如钙、镁或锌)配对，以便利用还原或螯合帮助暴露蛋白酶识别位点和/或增加其切割速率。
在替代的实施方案中，蛋白酶识别位点在将结合剂连接至固定化支持体的结构域/区域上提供。加入蛋白酶导致与结合剂结合的精子温和释放。
在又一个实施方案中，可以使用单独的或组合的螯合反应和还原反应由结合剂释放精子。例如，可以使用被工程改造或选择而整合至结合剂的锌离子螯合，以由精子释放结合剂。同时，可以利用二硫键将结合剂连接至固定化支持体。随后，还原将允许由支持体除去结合剂。在一种方法中，螯合需要还原，由此防止所述系统的重复作用。
本领域技术人员将认识到，其它方法可成功地用于由固定化结合剂温和释放精子。例如，生物素可用于精子结合位点。随后加入链霉抗生物素蛋白应除去生物素并释放精子。
在一个实施方案中，使用磁珠分选一次射精液的装置具有下表2中所述的技术条件。
表2
牛
细管中的精液 1.00E+07
性控的携带x的精子的细管/射精液的数目 100
如果回收50％的所需精子则开始所需要的总精子 4.00E+09
典型的公牛一次射精中的精子数 1.00E+10
所需的射精次数 0.4
细胞纯化效率 0.7
提取的精子数目 1.43E+09
珠/细胞比率 6
所需的珠数 8.57E+09
珠浓度/ml 3.00E+10
在该市售制剂中的体积(ml) 10
10ml中的总珠数 3E+11
用于单个牛性别确定装置的
-A蛋白体积(ml) 2.86E-01
用于12000个牛性别确定装置的
-A蛋白体积(ml) 3.43E+03
用于使用特异性结合剂分离携带X-染色体或Y-染色体的精子的替代方法包括：(i)凝集，之后过滤；(ii)具有两个官能团(例如A蛋白和生物素)的非磁性珠：所述珠如上所述使用，只是它们与包被链霉抗生物素蛋白或相似的生物素结合化合物的表面反应，而不是磁性分离；(iii)将抗体固定在允许柱层析类型方案的支持体上；和(iv)FAC。
提供以下的实施例是为了阐述，而不是为了限制。
实施例1
通过生物信息学鉴别候选基因
在基于基因组的方法中使用可公开获得的牛基因组(可在Ensembl站点上获得；最初于2006年8月14日发布；更新版于2007年2月发布)和可公开获得的人基因组，以鉴别在性控精子表面上的差异。具体地说，使用Ensembl Biomart工具(可在Ensembl站点上获得)和以下策略选择候选基因：
1)使用Biomart鉴别人X染色体基因的牛直系同源物，其具有跨膜结构域，并通过手工分析检查；
2)通过Biomart鉴别牛基因组中存在于X染色体上的并具有跨膜结构域的基因，并通过手工分析检查(未测序的牛Y染色体)；和
3)使用Biomart鉴别人Y染色体基因的牛直系同源物，其具有跨膜结构域，并通过手工分析检查(包含一种牛基因，该基因在牛中可能已经移动至X染色体)。
在除去冗余的命中结果后，鉴别出总共216个候选基因。
实施例2
基于表达水平区分候选基因的优先顺序
检查在实施例1中鉴别的每种候选基因，以观察是否有剪接变体，如果有，则选择所有转录物共有的外显子。如果不存在合适的外显子，则选择每种转录物独有的外显子用于引物设计。采用外显子用于引物设计，而不是越过内含子，以使所有的引物在基因组DNA上都被检验。还设计对照引物，以确保在cDNA中没有基因组DNA。使用Primer3软件(可由SourceForge在线获得)和80-150bp的产物大小设计引物，用于实时PCR。所有的引物都使用Blast软件检查，以证实它们不能在基因组中的其它位置引发(即至少引物的3’末端碱基不能匹配)。然后在逆转录PCR研究中使用设计的引物，以分析候选基因在牛睾丸组织cDNA和牛基因组DNA中的表达。
在初始的216种候选基因中，显示出136种在牛睾丸组织中表达。然后通过应用基于如下所述的表达和亚细胞定位的标准区分这些基因的优先顺序。
圆形精细胞是正在发育的精细胞，其已经历减数分裂，且与成熟精子不同，其转录RNA。圆形精细胞(RS)分化为精子(成熟精子)，没有细胞分裂，因此代表鉴定精子中的表达基因的良好候选物。
通过显示鼠精子表面上存在的蛋白和鼠RS中的mRNA表达之间的高度相关，证实了该方案的可行性。使用来自两个高质量出版物的数据进行该比较。第一个出版物(Stein等人，2006)通过使用膜纯化和质谱的组合组装了在精子表面膜上存在的82种蛋白。然后在第二个出版物(Shima等人，2004)提供的鼠RS中检验了这82种蛋白的mRNA表达。在这82种基因中，有71种基因的数据，在这71种中，67种以RNA水平表达基因(94％)。该结果证实，在RS中的mRNA表达是精子蛋白的良好间接量度。
开发鼠数据组，以进一步考察已知在细胞表面上存在的基因产物在RS中的相对RNA表达量，并与候选物的鼠直系同源物的RNA表达水平相比较。该分析的结果示于图1，证实候选基因一般以比已知精子蛋白的随机选择低得多的水平表达(71种基因中约有30种有表达数据)。这些结果潜在地解释了为什么研究者迄今为止还不能发现携带X染色体或Y染色体的精子之间的表面差异，并表明这样的差异将需要非常灵敏的工具来检测和开发。
这些结果还允许基于相对表达量区分候选基因的优先顺序。除一种基因以外，Stein等人(出处同上)检测的蛋白具有大于40的RNA表达水平，因此该数值被用作针对最佳候选物的阈值。基于鼠直系同源物，高优先级的候选基因(在图1中以框表示)全部具有40或以上的相对表达水平。已知由精子上的抗体检测的其它蛋白检验表明表达水平范围为9-1000(参见表3)。
表3：在精子上检测的蛋白质及其在鼠RS中的mRNA表达
| 基因名称 | 在RS中的mRNA表达(NCBI GEO) | 其中检测到种属精子蛋白 | 参考文献 |
| Ph20 spam1 | 1000 | 牛 | PMID：15892045；Morin |
| 等人，Mol.Reprod.Dev.71：523-534(2005) | |||
| Csf2ra | 65 | 人/牛 | PMID：11169747；Zambrano等人，J.CellBiochem.80：625-634(2001) |
| Csf2rb1 | 20 | 人/牛 | PMID：11169747；Zambrano等人，J.CellBiochem.80：625-634(2001) |
| Trpc1 | 40 | 人/小鼠 | PMID：12706821；Castellano等人，FEBSLett.541：69-74(2003)；PMID：11734218；Trevino等人，FEBS Lett.509：119-125(2001) |
| Cnr2 | 14 | 公猪 | PMID：16144868；Maccarrone等人，J.CellSci.118：4393-4404(2005) |
| Cnr1 | 50 | 公猪 | PMID：16144868；Maccarrone等人，J.CellSci.118：4393-4404(2005) |
| drd2 | 47 | 大鼠、小鼠、人和公牛 | PMID：16924680；Otth等人，J.Cell Biochem.100：141-150(2007) |
| 基因名称 | 在RS中的mRNA表达(NCBI GEO) | 其中检测到种属精子蛋白 | 参考文献 |
| CCR5 | 9 | 人 | PMID：16174786；Muciaccia等人，FasebJ.19：2048-2050(2005) |
| il6st | 50 | 人 | PMID：16728717；Cai等人，J.Androl.27：645-652(2006) |
PMID＝Medline标识符(unique Public Medline identifier)
实施例3
基于亚细胞定位区分候选基因的优先顺序
候选基因在圆形精细胞中的低表达水平提示，如果候选基因仅存在于非细胞表面的膜上，那么这些候选物应被给予较低的优先级。此举的原因在于：由于候选物已低表达，其又伴有蛋白在表面上仅以低百分率存在将使候选物非常难以检测。因此检验候选基因或其在其它物种中的直系同源物，以测定基因产物的亚细胞位置。如果得到蛋白处于非细胞表面的膜系统上的证据，那么将给予该候选物较低优先级。该数据与圆形精细胞表达数据组合，产生4种不同优先级的基因类别，I类为最高优先级。在以下表4中标示的每种I类牛候选基因均具有以下特征：
■鼠直系同源物基因在鼠圆形精细胞中于阈值水平(参见上文)之上表达；
■所述基因在公牛睾丸组织中表达；
■基因产物非常可能存在于细胞膜中；和
■已知基因产物存在于细胞表面上，或者没有证据表明基因产物不存在于细胞表面上。
表4：I类候选牛基因
| 牛基因Ensembl ID | 基因名称 | 氨基酸SEQID NO： | DNA SEQID NO： |
| ENSBTAG00000000520 | ATP2B3 | 1 | 22 |
| ENSBTAG00000005616 | BRS3 | 2 | 23 |
| ENSBTAG00000006296 | 未知1 | 3 | 24 |
| 牛基因Ensembl ID | 基因名称 | 氨基酸SEQID NO： | DNA SEQID NO： |
| ENSBTAG00000006818 | FAM11A | 4，138 | 25，137 |
| ENSBTAG00000007859 | VSIG1 | 5 | 26 |
| ENSBTAG00000009959 | SLC6A8 | 6，140 | 27，139 |
| ENSBTAG00000010018 | ATP7A | 7，142 | 28，141 |
| ENSBTAG00000012718 | XK | 8，144 | 29，143 |
| ENSBTAG00000013462 | L1CAM | 9 | 30 |
| 牛基因Ensembl ID | 基因名称 | 氨基酸SEQID NO： | DNA SEQID NO： |
| ENSBTAG00000014798 | CXCR3 | 10 | 31 |
| ENSBTAG00000016484 | ATP11C | 11，146 | 32，145 |
| ENSBTAG00000017801 | ATP6AP2 | 12，148 | 33，147 |
| ENSBTAG00000019552 | PGRMC1 | 13 | 34 |
| ENSBTAG00000035134 | 未知2 | 14，150 | 35，149 |
| ENSBTAG00000001338 | CCR3 | 15 | 36 |
| ENSBTAG00000002923 | CX3CR1 | 16，152 | 37，151 |
| ENSBTAG00000005781 | 未知3 | 17，154 | 38，153 |
| ENSBTAG00000015801 | EFNB1 | 18 | 39 |
| ENSBTAG00000020826 | CHIC1 | 19 | 40 |
| ENSBTAG00000032501 | 未知4 | 20，156 | 41，155 |
| ENSBTAG00000034045 | FMR1NB | 21，158 | 42，157 |
| ENSBTAG00000014533 | Kel | 160 | 159 |
| 牛基因Ensembl ID | 基因名称 | 氨基酸SEQID NO： | DNA SEQID NO： |
| ENSBTAG00000035195 | 未知5 | 162 | 161 |
| ENSBTAG00000035944 | 未知6 | 164 | 163 |
基于与不同哺乳动物直系同源物的比较，发现在SEQ ID NO：1-42中提供的某些序列可能预测错误。修改后的更精确的序列提供于SEQ ID NO：137-158。
对应于候选牛基因的人基因标示于表5。
表5：I类候选人基因
| 牛基因Ensembl ID | 人基因EnsemblID | 人基因名称 | 人DNASEQ IDNO： | 人氨基酸SEQ IDNO： |
| ENSBTAG00000000520 | ENSG00000067842 | ATP2B3PMCA3 | 122，120，133，131，127，135 | 77，73，86，84，80，88 |
| ENSBTAG00000001338 | ENSG00000183625 | CCR3 | 95 | 48 |
| ENSBTAG00000002923 | ENSG00000168329 | CX3CR1 | 107 | 60 |
| ENSBTAG00000005616 | ENSG00000102239 | BRS3 | 96 | 49 |
| 牛基因Ensembl ID | 人基因EnsemblID | 人基因名称 | 人DNASEQ IDNO： | 人氨基酸SEQ IDNO： |
| ENSBTAG00000005718 | ENSG00000124103 | 未知3 | 97，94，91 | 50，47，44 |
| ENSBTAG00000006296 | ENSG00000160131 | 未知1 | 118，123 | 71，76 |
| ENSBTAG00000006818 | ENSG00000155984 | FAM11A | 117 | 80 |
| 牛基因Ensembl ID | 人基因EnsemblID | 人基因名称 | 人DNASEQ IDNO： | 人氨基酸SEQ IDNO： |
| ENSBTAG00000007859 | ENSG00000101842 | VSIG1 | 90 | 43 |
| ENSBTAG0000009959 | ENSG00000130821 | SLC6A8CTI | 119，121，124 | 72，74，75 |
| ENSBTAG00000010018 | ENSG00000165240 | ATP7A | 110，100，101，93，106 | 63，53，54，46，59 |
| ENSBTAG00000014798 | ENSG00000186810 | CXCR3 | 108，112，109 | 61，65，62 |
| ENSBTAG00000015801 | ENSG00000090776 | EFNB1 | 92 | 45 |
| ENSBTAG00000016484 | ENSG00000101974 | ATP11C | 111，126，115，114，125 | 64，79，68，67，78 |
| ENSBTAG00000017801 | ENSG00000182220 | Renin受体 | 102 | 55 |
| ENSBTAG00000019552 | ENSG00000101856 | PGRMCI | 105 | 58 |
| ENSBTAG00000020826 | ENSG00000204116 | CHIC1 | 99，98 | 52，51 |
| ENSBTAG00000034045 | ENSG00000176988 | FMR1NB | 113，116 | 66，69 |
| ENSBTAG00000035134 | ENSG00000189118 | 未知2 | 104 | 57 |
| ENSBTAG00000014533 | ENSG00000197993 | Kel | 202 | 201 |
对应于候选牛基因的马基因在表6中标示。
表6：I类候选马基因
| 牛基因Ensembl ID | 马基因Ensembl ID | 马基因名称 | 马DNASEQ IDNO： | 马氨基酸SEQ IDNO： |
| ENSBTAG00000001338 | ENSECAG00000001282 | CCR3 | 165 | 183 |
| ENSBTAG00000013462 | ENSECAG00000002810 | L1CAM | 166 | 184 |
| ENSBTAG00000002923 | ENSECAG00000004442 | CX3CR1 | 167 | 185 |
| ENSBTAG00000035134 | ENSECAG00000005133 | 168 | 186 | |
| 牛基因Ensembl ID | 马基因Ensembl ID | 马基因名称 | 马DNASEQ IDNO： | 马氨基酸SEQ IDNO： |
| ENSBTAG00000016484 | ENSECAG00000005393 | ATP11C | 169 | 187 |
| ENSBTAG00000005616 | ENSECAG00000008806 | BRS3 | 170 | 188 |
| ENSBTAG00000006818 | ENSECAG00000009399 | Fam11a | 171 | 189 |
| ENSBTAG00000019552 | ENSECAG00000009619 | PGRMC1 | 172 | 190 |
| ENSBTAG00000014533 | ENSECAG00000010525 | KEL | 173 | 191 |
| ENSBTAG00000015801 | ENSECAG00000012319 | EFNB1 | 174 | 192 |
| ENSBTAG00000009959 | ENSECAG00000013965 | 175 | 193 | |
| ENSBTAG00000012718 | ENSECAG00000014332 | XK | 176 | 194 |
| ENSBTAG00000020826 | ENSECAG00000016317 | CHIC1 | 177 | 195 |
| ENSBTAG00000010018 | ENSECAG00000016767 | ATP7A | 178 | 196 |
| ENSBTAG00000007859 | ENSECAG00000018968 | VSIG1 | 179 | 197 |
| ENSBTAG00000017801 | ENSECAG00000019889 | ATP6AP2 | 180 | 198 |
| ENSBTAG00000000520 | ENSECAG00000023490 | ATP2B3 | 181 | 199 |
| 牛基因Ensembl ID | 马基因Ensembl ID | 马基因名称 | 马DNASEQ IDNO： | 马氨基酸SEQ IDNO： |
| ENSBTAG00000014798 | ENSECAG00000023587 | CXCR3 | 182 | 200 |
除了3种基因以外，所有的I类候选基因均选自人、牛或马的X染色体。两篇论文提及的两种例外情况均为趋化因子受体，两篇论文的作者观察到，当用对趋化因子受体(CCR3 & CX3CR1)特异性的抗体染色精子时，仅50％的精子染色(Muciaccia等人，Faseb J.19：2048-2050(2005)；Zhang等人，Hum.Reprod.19：409-414(2004))。这两种趋化因子受体均紧密聚簇在牛染色体22上，在研究它们的启动子区域后，发现GATA-1(X-编码的转录因子)有可能结合并控制它们的表达(DeVries等人，J.Biol.Chem.278：11985-11994(2003)；Garin等人，Biochem.J.368：753-760(2002)；Vijh等人，Genomics 80：86-95(2002)；Zimmermann等人，Blood 96：2346-2354(2000))。另一种例外的kel是二硫键连接的XK蛋白的配偶体(Lee等人，Semin.Hematol.37：113-121(2000)；Russo等人，Biochim.Biophys.Acta 1461：10-18(1999)；Russo等人，J.Biol.Chem.273：13950-13956(1998))。
Stein等人(Proteomics 6：3533-3543(2006)；另参见Baker等人，Proteomics 8：1720-1730(2008))的蛋白质组研究已表明，本申请公开的一种候选基因的小鼠直系同源物(pgrmc1；小鼠蛋白ENSMUSG00000006373；牛蛋白ENSBTAG00000019552，SEQ ID NO：13)存在于精子膜上。另外，业已表明，使用本申请所述方法鉴别的另一个I类候选抗原的小鼠直系同源物(小鼠蛋白ENSMUSG00000031130：牛蛋白ENSBTAG00000005616；SEQ ID NO：2)在发育中的精子上表达(Fathi等人，J.Biol.Chem.268：5979-59841993))。
实施例4
产生抗体检测试剂和测试所表达的基因在精子表面上的存在情况
I类候选基因的获得使它们能被进行仔细检验以确定在它们的预测序列中的潜在错误。基于和其它哺乳动物直系同源物的比较，发现几种候选基因具有潜在的预测错误，通过克隆cDNA的任一个部分或完整可读框，并测序这些区域，产生并测试新基因模型。在膜中的I类候选蛋白的构型由文献确定或建模，并用于选择肽(用于产生抗体)。
对于每种I类候选基因，制订特别的策略，以显示所述蛋白质存在于精子表面上，并验证基因产物针对携带X-染色体或Y-染色体的精子是特异性的。在以下表7中显示的这些策略包括使用牛和/或人精子，由市售获得抗体和/或通过基于两种不同的肽的方案产生获得抗体，并针对候选基因中的三种，表达和纯化重组蛋白。
表7
| SEQ IDNO： | 基因名称 | 膜类型 | 策略 |
| 1 | ATP2B3PMCA3 | 10TM | 市售抗体和Siscapa方案 |
| 15 | CCR3 | 7TM | 市售抗体 |
| 16 | CX3CR1 | 7TM | 市售抗体 |
| 2 | BRS3 | 7TM | 市售抗体加Siscapa方案 |
| 17 | 未知3 | I型 | 肽抗体和Siscapa方案 |
| SEQ IDNO： | 基因名称 | 膜类型 | 策略 |
| 3 | 未知1 | 2TM | 肽抗体和Siscapa方案 |
| 4 | FAM11A | 8TM | 肽抗体和Siscapa方案 |
| 5 | VSIG1 | I型 | 表达胞外结构域并产生抗体，以及Siscapa方案 |
| 6 | SLC6A8 CT1 | 12TM | 肽抗体、一种市售抗体和Siscapa方案 |
| 7 | ATP7A | 8TM | 市售抗体和Siscapa方案 |
| 8 | XK | 10TM | 市售抗体(XK和Kell这二者)和Siscapa方案 |
| 9 | L1CAM | I型 | 市售抗体和Siscapa方案 |
| 10 | CXCR3 | 7TM | 市售抗体 |
| 18 | EFNB1 | I型 | 表达胞外结构域并产生抗体，以及Siscapa方案 |
| 11 | ATP11C | 10TM | 肽抗体，还购买了一种人肽抗体和Siscapa |
| SEQ IDNO： | 基因名称 | 膜类型 | 策略 |
| 12 | Renin受体 | I型 | 表达胞外结构域并产生抗体，以及Siscapa方案 |
| 13 | PGRMC1 | 1TM | 肽抗体、一种市售抗体和Siscapa方案 |
| 19 | CHIC1 | 1TM | 肽抗体和Siscapa方案 |
| 20 | 未知4 | I型 | 肽抗体和Siscapa方案 |
| 21 | FMR1NB | 2TM | 肽抗体、一种市售抗体和Siscapa方案 |
| 14 | 未知2 | 4TM | 仅肽抗体 |
产生肽的抗体经常具有一定的效价范围，且不一定识别天然蛋白或在SDS-PAGE凝胶上变性的蛋白。另外，内在膜蛋白(大部分I类候选物)经常难以溶解，并因此难以进入PAGE凝胶系统(Peirce等人，Mol.Cell.Proteomics 3：56-65(2004)；Santoni等人，Electrophoresis21：3329-3344(2000))。我们对这些问题的解决方案如下：每种蛋白产生多个肽-抗体，并使用各种检测技术检测这些抗体，例如直接细胞表面结合(流式细胞术)、细胞裂解测定、抗体精子捕获、蛋白质印迹和/或固定的精细胞的免疫组织化学。在另一个克服产生肽的抗体的某些问题的策略中，使用质谱检测候选精子表面蛋白。
这些实验具有两个目标：首先，确定精子中是否存在任一种候选基因；其次，如果存在，则确定候选物是否在质膜上，确定在携带X染色体或Y染色体的精子之间的分布，并证实结合物质的身份。为达到高测定通量，在有可能的情况下使用机器人站连同96/384孔板进行设置和进行测定。
a)抗体和/或抗血清的生产
使用以下描述的策略设计用于生产针对SEQ ID NO：1-9、11-14和17-21的I类候选抗原的抗体的肽。以下为用于肽选择/设计的两种设计策略。在第一种策略中，应用标准肽设计规则设计优先结合表面暴露表位的肽，然而，如果不能获得足够的表面表位，则使用胞质表位。简而言之，用于设计肽的方案如下：选择N-末端、C-末端和连接跨膜结构域的小环(其已被作图在序列上；预期信号序列从所述序列中除去以用于肽选择)；并选择具有以下特征的序列：具有合适的亲水性(-0.5至0.5)，不以谷氨酸或谷氨酰胺开始，不具有任何cys残基，不具有可能的糖基化位点且不与其它蛋白密切相关。所有的肽通常都在c-末端具有接头(GSGC)，以能够特异性偶联至载体蛋白、ELISA板和/或琼脂，用以亲和纯化抗血清。然而，对于处于蛋白的最C-末端的肽，将接头CGSG加至N-末端。在第二种策略中，依据Anderson等人(J.Proteome Res.3：235-244(2004))的方法设计用于SISCAPA技术的肽。基本上该技术为ELISA，检测阶段为质谱。
在设计和生产肽后，将肽缀合至载体KLH，并使用标准技术免疫兔，以生产抗血清。还可以将肽缀合至第二种载体，以用作多种测定中的阳性对照。或者，可以使用具有共价连接的马来酰亚胺基团(cys反应基团)的ELISA板。对于每种候选基因，将两种肽同时免疫入兔中，每对肽免疫两只兔子。该方法用于动物时是有效的，使获得具有所需活性的抗体的可能性最大化，且用亲和纯化抗体获得单特异性抗血清(Larsson等人，J.Immunol.Methods 315：110-120(2006)；Uhlen和Ponten，Mol.Cell.Proteomics 4：384-393.(2005))。
通过ELISA测试抗血清对免疫肽的识别。简而言之，纯化的肽通过每个肽上的游离巯基(cys残基)特异性结合ELISA板。游离巯基与具有马来酰亚胺表面的ELISA微量滴定板(Corning)反应，由此允许所述肽经巯基不可逆结合。在肽结合后，对所述肽滴定抗血清(预免疫的和最终抽血的)。随后加入缀合HRP的抗兔抗体，并使用OPD显色信号。
结果表明，对于用于免疫的54种肽，对25种肽获得了具有0.001或以下的特异性肽结合效价的抗血清。利用标准技术在具有通过游离巯基特异性附着的肽的柱子上纯化效价低于0.001的抗血清。脱盐的抗体用于随后的测定。
b)抗体与候选基因产物的结合
如下测定抗体对候选基因产物的特异性。克隆大部分候选物的基因，以便使它们能够用作阳性对照。购买或克隆基因，然后将基因转移至Invitrogen表达载体pcDNATM3.2/V5-DEST。这些质粒用于通过磷酸钙方法瞬时转染HEK 293T细胞。在48-72小时后，由培养皿上刮下细胞，用于流式细胞术研究，或者直接用于产生完整的细胞裂解物。
能够比较模拟物转染的HEK细胞或用适宜的表达载体转染的HEK细胞并随后用候选抗体进行流式细胞分析使得可以证实所述抗体对候选基因产物是特异性的。结果概述于以下表8。
表8
| 候选物 | 依据流式细胞术显示出特异性结合瞬时转染的HEK293T细胞的抗体鉴定 |
| CCR3 | (SC32777；SC7897；MAB155) |
| CX3CR1 | (SC20432；SC30030) |
| BRS3 | (SC33404) |
| FAM11A | (GN21352) |
| VSIG1 | (VSIG) |
| 候选物 | 依据流式细胞术显示出特异性结合瞬时转染的HEK293T细胞的抗体鉴定 |
| XK | (SC50201；SC50202) |
| Kel | (IBGRL9440；IBGRL9441；AF1914) |
| L1CAM | (SC33686；SC31034；SC53386；SC15326) |
| CXCR3 | (SC57076；SC9900) |
c)针对结合候选基因产物的物质的测定
由于产生肽的抗体结合靶蛋白的性质难以预测(即抗体是否将识别天然蛋白和/或变性形式)，所以使用多种测定。检查抗体或其它物质与候选基因产物的结合的测定包括以下测定，其通过起始物质和所用的测定进行分类(参见图2)：
●I类测定：使用流式细胞术、细胞裂解和/或免疫纯化进行的完整精子测定；
●II类测定：使用免疫组织化学型方案和/或流式细胞术读取的固定化精子测定；和
●III类测定：精子表面膜蛋白制备，之后为蛋白质印迹、SISCAPA和/或iTraq方案。
I类测定
这些测定使用新鲜的或由在液氮中冷冻的等份试样融化的活精子。牛精子通过PercollTM梯度纯化，以产生存活的、高活力的、形态正常的且可育的精子群(Samardzija等人，Anim.Reprod.Sci.91：237-247(2006)；Trentalance and Beorlegui，Andrologia 34：397-403(2002))。该程序先前已用于新鲜精子和冷冻精子。I类测定利用上述抗体/结合剂，检测包含流式细胞术，Alexa Fluor缀合的二抗(Invitrogen Corp.，Carlsbad，CA)作为报告体系统，用顺磁珠免疫捕获精子，还进行免疫沉淀，之后通过质谱检测释放的胰蛋白酶消化的蛋白。
II类测定
使用免疫组织化学的基本原理在于固定可以改变蛋白表位，并可以产生某些在天然蛋白中没有的表位。在使用前，牛精子在PercollTM梯度上纯化，然后固定在不同的固定剂范围(3-4)内。再使用上述抗体/结合剂，以流式细胞仪或基于ELISA板的形式读取结合数据。
III类测定
III类测定可能对检测低丰度抗原最敏感。在PercollTM梯度上再次纯化牛精子，然后通过两种不同的技术制备精子质膜蛋白组分。第一种方法生物素化完整精子的表面，质膜蛋白随后在天然抗生物素蛋白上分离，并用于多种测定(Zhao等人，Anal.Chem.76：1817-1823(2004))。还可以使用第二种方法，其用于质膜蛋白制备，包括更传统的氮空腔/沉淀和去垢剂溶解(Lalancette等人，Biol.Reprod.65：628-636(2006))。使用两种不同的膜蛋白分离技术，因为所有方法对不同蛋白的分离都具有一定选择性。
在富集精子质膜后，在以下的三种测定中使用样品：
(i)蛋白质印迹
蛋白质印迹的关键问题是使足量的富集质膜蛋白加入PAGE凝胶，同时仍使凝胶良好解析并提供足够的灵敏度。在将质膜富集样品加载到PAGE凝胶上之前，可以使用进一步的简单分级分离，例如使用离心柱进行简单的大小截流，例如保留10Kd以上的物质。还可以使用去垢剂/相分离选择某些类型的膜蛋白，例如一步或多步(Santoni等人，Electrophoresis 21：3329-3344(2000))。总之，目标是建立基于知识的富集(使用候选基因信息)，而不产生额外的样品，因此可针对不同处理分组候选基因。在一个实施方案中，首先用几种抗体免疫沉淀蛋白，然后使用蛋白质印迹鉴别捕获蛋白。
(ii)SISCAPA
SISCAPA技术的概述示于图3。与标准技术的主要差异在于将使用不同的起始物质，即与人胞质蛋白相对的精子质膜，省略同位素标记肽。
SISCAPA技术设计用于特异性鉴别和定量人胞质中的蛋白，所述蛋白被多种代谢或病症改变(Anderson等人，2004，出处同上)。该强大的技术具有几个优势：
●使用抗体富集样品肽，因此减少了质谱分析的复杂性；
●针对肽产生的抗体几乎总能识别所述肽，其与亲代蛋白不同；
●掺杂的肽(spiked peptides)(就Anderson实验而言为同位素标记)允许质谱仪明确地鉴别肽，且还定量内源蛋白。在本研究中，使用与用于免疫的肽相同的肽实施SISCAPA方法，而不是使用同位素标记的肽。该肽用作标准品，以在质谱仪中确定所述肽的飞行特征。用于本研究的肽具有GSGC接头，然而其将在碱性残基之后，因此用胰蛋白酶消化所述肽将提供精确的肽作为质谱仪的内标；
●起始样品的胰蛋白酶消化也具有显著优势，尤其是对于其中消化肽能够溶解和分离的膜蛋白，采用疏水性亲代蛋白的任务明显更难；和
●应用于抗体的样品量不受限，因此能使非常大量的精细胞质膜(＞108个细胞等效物)通过抗体，这又提供了可能非常高灵敏度的技术。
(iii)iTRAQ
TM
Applied Biosystems iTRAQTM试剂是一组复合的四同重元素试剂，其为胺特异性的，产生质量相同的标记肽，因此就单MS模式而言也是相同的，但其产生强的、诊断性的、低质量的MS/MS标签离子，允许同时定量多达4种不同的样品。利用改进的片段化模式简化蛋白鉴别，MS或MS/MS模式没有信号拆分，将多个蛋白质组样品混合在一起而不会增加MS和MS/MS数据的复杂性。本研究使用如在图4中所示的iTRAQTM技术。与用于本研究的其它技术相反，首先通过流式细胞仪将精子分为携带X染色体或Y染色体的两个群。然后这些分拣的样品与iTRAQTM试剂一起使用。
实施例5
结合精细胞的抗体和通过流式细胞术分析
对于本申请公开的10种候选基因，如下使用流式细胞仪显示出对候选蛋白特异性的抗体结合人、牛或这二者的精子。
通过离心在PercollTM(GE Healthcare)不连续密度层上纯化新鲜精子。在洗涤后，精子的目测显微镜观察显示出基本上纯的精子群。来源于单次射精液的人精子具有总计数40-120×106个精子的浓度范围(20-60×106/ml)，活动力目测评价平均＞60％。牛精子平均浓度为1.5×109/ml，总计数约10×109个精子，活动力目测评价平均大于70％。使用Invitrogen LIVE/DEAD精子活力试剂盒(SYBR-14/碘化丙锭)评价纯化的精子的活力。一般而言，据精子活力试剂盒(Sperm Viability Kit)评价，精子显示出大于80％的活力。另外，通过LysotrackerTM(Invitrogen)分析表明，低于20％的精子是顶体反应性的，该比例等于由精子活力分析获得的死亡总数。
通过标准技术进行纯化精子的抗体染色。简而言之，将纯化的精子与它们的一抗温育，洗涤，并用Alexa Fluor 488TM缀合的二抗标记。在分析前，还用碘化丙锭染色细胞。通过碘化丙锭染色排除死亡的精子，对于每个分析，在Becton-Dickinson FACScalibur中收集30,000个事件。
这些研究的结果概述于下表9和10。在显示出候选抗体与精子的特异性结合时，对1个以上个体的精液样品也实现了这一点。
表9
| 候选物 | 流式细胞术显示结合人精子的抗体数/测试抗体数 | 流式细胞术显示结合人精子的抗体的鉴定 |
| CCR3 | 2/3 | SC7897；MAB155 |
| CX3CR1 | 2/3 | SC20432；SC30030 |
| BRS3 | 1/2 | SC33404 |
| FAM11A | 1/2 | GN21352 |
| VSIG1 | 0/1 | |
| XK | 2/3 | SC50201；SC50202 |
| Kel | 3/3 | IBGRL9440；IBGRL9441；AF1914 |
| L1CAM | 3/5 | SC31034；SC53386；SC15326 |
| CXCR3 | 2/4 | SC57076；SC9900 |
| FMR1NB | 1/1 | FMR1NB |
表10
| 候选物 | 流式细胞术显示结合人精子的抗体数/测试抗体数 | 流式细胞术显示结合人精子的抗体的鉴定 |
| CCR3 | 1/3 | SC7897 |
| CX3CR1 | 1/3 | SC30030 |
| BRS3 | 1/2 | SC33404 |
| FAM11A | 1/2 | GN21352 |
| VSIG1 | 1/1 | VSIG |
| XK | 2/3 | SC50201；SC50202 |
| Kel | 3/3 | IBGRL9440；IBGRL9441；AF1914 |
| L1CAM | 2/5 | SC53386；SC15326 |
| CXCR3 | 2/4 | SC57076；SC9900 |
| FMR1NB | 1/1 | FMR1NB |
显示出特异性结合的精细胞的百分率随下表11中所示的抗体而变化。
表11
| 抗原 | 类别 | 用于结合实验的精子种类 | 表现出特异性结合的精细胞(％) |
| XK；ENSG00000047597 | 候选物 | 人 | 24.2 |
| CCR3；ENSG00000183625 | 候选物 | 人 | 31.7 |
| BRS3；ENSG00000102239 | 候选物 | 人 | 10.7 |
| CX3CR1；ENSG00000168329 | 候选物 | 人 | 10.5 |
| CXCR3；ENSG00000186810 | 候选物 | 人 | 11.9 |
| FMR1NB；ENSG00000176988 | 候选物 | 人 | 29.7 |
| 抗原 | 类别 | 用于结合实验的精子种类 | 表现出特异性结合的精细胞(％) |
| FAM11A；ENSBTAG00000006818 | 候选物 | 牛 | 8.4 |
| KEL；ENSG00000197993 | 候选物 | 人 | 14.4 |
| L1CAM；ENSG00000198910 | 候选物 | 人 | 19.0 |
| VSIG1；ENSBTAG00000007859 | 候选物 | 牛 | 5.2 |
| CD55 | 对照 | 人 | 71.0 |
对于显示出较高结合百分率的实例，即XK、CCR3、FMR1NB和L1CAM，在双峰分布中有明显的抗体结合证据，第一个峰与二抗唯一的峰一致，第二个分布具有约1-100倍以上的荧光。显示出较低细胞结合百分率的抗体表现出荧光分布的时滞(相对于二抗唯一的峰)，具有1-10倍以上的荧光。这些结果与使用抗CD55抗血清作为已知结合精子表面的抗体获得的数据相反。该抗体特异性结合71％的精子，然而，对单独的二抗以及一抗和二抗一起来说，均存在单模式结合分布，不过对于后一结合来说，整个峰由于较大的荧光而迁移。由于抗体结合随着可用的结合位点的数目和抗体的亲合力而变化，所以低于50％的细胞结合抗体可能表明，在精子表面上存在非常低的分子表达(采用所用的试剂在检测以下)和/或不是所有的精子都携带候选抗原。
一般而言，结合人精子的抗体比结合牛精子的抗体多。该结果应当是可预期的，因为大部分抗体针对人蛋白产生。候选蛋白一般在人和牛之间是高度保守的，然而氨基酸序列的微小变化(取决于表位)可以降低抗体对蛋白的亲合力。
实施例6
结合精细胞制备物的抗体和通过蛋白质印迹分析
如下通过蛋白质印迹检验针对候选基因产物的抗体结合精细胞制备物的能力。
对纯化的精子进行超声，通过离心除去核，通过超离心分离总的膜组分。在8％Bis-Tris聚丙烯酰胺凝胶(Invitrogen)上分离来自膜组分的蛋白，并转移至硝酸纤维素膜(NC；Invitrogen i-Blot)。用脱脂奶封闭NC膜，与对目标蛋白特异性的一抗温育，然后与缀合辣根过氧化物酶的二抗温育。用化学发光的ECL蛋白质印迹底物显色印迹，并使用LAS-3000成像系统(Fuji)检测信号。
在蛋白质印迹中，使用对人kel特异性的抗体AF914，检测刚好跑在100kD之下的条带。该条带出现在加载0.8×108个人精子的膜制备物的泳道上。几乎同样大小的条带也出现于加载HEK细胞的全细胞裂解物的蛋白质印迹中，所述HEK细胞用表达人kel基因的pCDNA载体转染。相比之下，未转染的HEK细胞的全细胞裂解物没有显示出抗体特异性结合。
将在兔中制备的针对牛EFBN1基因的重组胞外结构域的抗体用于探测牛精子的蛋白质印迹。在这些实验中，将由1×109个人精子得到的膜制备物在SDS-PAGE上跑电泳，印迹到硝酸纤维素上，并使用抗EFBN1抗体检测EFBN1蛋白。精子膜泳道显示出于50kd存在条带。用免疫前抗血清探测的相同泳道没有显示出相似的条带。在氨基酸水平上96％相同的人EFBN1已显示出跑到50kD处(PMID17567680)。
实施例7
证实已鉴别出精子性别特异性抗原
如下证实已通过多个测定中的“命中结果”鉴别出性别特异性抗原的指示。该确证包括两个方面：首先，识别预期的分子；其次，识别的蛋白实际上位于细胞表面上，而且所述蛋白隔离携带X染色体或Y染色体的精子。以上的某些测定强有力地表明了所需特征，例如用完整的精子免疫纯化表明所述分子是表面暴露的。然而，所述技术未表明隔离X染色体或Y染色体。该特征可通过流式细胞术、PCR和/或如下所述的FISH分析确定。在使用流式细胞术时，以Johnson等人(Johnson，Anim.Reprod.Sci.60-61：93-107(2000))所用的方法检验精子大小分布。对于通过PCR分析，对X和Y染色体特异性的引物与实时PCR一起用于定量性染色体与精细胞的分布(Alves等人，Theriogenology 59：1415-1419(2003)；Kageyama等人，J.Vet.Med.Sci.66：509-514(2004)；Parati等人，Theriogenology 66：2202-2209(2006))。诸如蛋白质印迹和SISCAPA的其它技术表明了由所述物质结合的分子的身份。
a)流式细胞术
在本实验设计中，精子用已显示出结合精子的候选抗体染色，用缀合Alexa FluorTM的二抗(Invitrogen)识别一抗。细胞同时用Hoechst33342-染料(基于DNA含量用于精子的流式细胞术性别分选的染料)染色。该方案允许精子针对DNA含量和结合剂识别染色(Johnson等人，Hum.Reprod.8：1733-1739(1993))。用特异性结合X-染色体特异性抗原的候选抗体标记的精子，将富集携带X-染色体的精子(即结合更多的Hoechst染料的那些)。
b)流式细胞仪分拣结合实时PCR
在本研究中，将在流式细胞仪上结合候选抗体的精子分选为两个群中，即染色和非染色精子。由两个群体制备DNA，每个样品中的X-染色体和Y-染色体的量通过实时PCR测定，例如通过使用
Duo DNA定量试剂盒(Applied Biosytems)。该方案能够提供在两个群体中存在的X染色体和Y染色体的精确的相对量。
该方案的变型是使用候选结合抗体和磁珠，以将精子分选入两个群(结合和非结合)中，然后使用流式细胞仪检测DNA含量(并因此测定X∶Y比率)，或使用实时PCR，以表明选定细胞上的X-染色体和Y-染色体的比率。
c)FISH(荧光原位杂交)分析
能够测定候选的抗体结合精子中的X∶Y比率的方法是使用对X-染色体和Y-染色体具有特异性的FISH探针。在该方案中，首先使精子结合第一候选抗体，接着结合荧光标记的二抗。随后固定细胞，透过，并用FISH探针染色。在洗涤步骤后，在荧光显微镜下观察细胞，确定对候选抗体阳性的精子的X∶Y染色比率。
尽管已参照本发明的具体实施方案描述了本发明，但本领域技术人员应当理解，在不偏离本发明的精神实质和范围的情况下，可以实施多种改变，并可以以等价方案替换。另外，可以实施许多修改，以适应具体的环境、材料、物质组成、方法、一个或多个方法步骤，以用于实施本发明。所有这些修改都属于随附的权利要求的范围。
所有的出版物、专利申请和在该申请中提及的专利都通过引用整体结合到本申请中，其程度如同将每个单独的出版物、专利申请或专利分别加以具体单独说明通过引用整体结合到本申请中。
SEQ ID NO：1-202列示于所附的序列表。用于随附的序列表的核苷酸序列的编码，包括符号“n”，符合WIPO标准ST.25(1998)，附件2，表1。
序列表
<110>Hudson，Keith R.
Ravelich，Susan
<120>用于精子性别选择的材料和方法
<130>13420.1001PCT
<160>202
<170>FastSEQ for Windows Version 4.0
<210>1
<211>1220
<212>PRT
<213>牛
<400>1
Met Gly Asp Val Ala Asn Ser Ser Ile Glu Phe His Pro Lys Pro Gln
1 5 10 15
Gln Gln Arg Glu Ala Pro His Ala Gly Gly Phe Gly Cys Thr Leu Ala
20 25 30
Glu Leu Arg Ser Leu Met Glu Leu Arg Gly Ala Glu Ala Leu Gln Lys
35 40 45
Val Gln Glu Ala Tyr Gly Asp Val Ser Gly Leu Cys Arg Arg Leu Lys
50 55 60
Thr Ser Pro Thr Glu Gly Leu Ala Asp Asn Ala Asn Asp Leu Glu Lys
65 70 75 80
Arg Arg Gln Ile Tyr Gly Gln Asn Phe Ile Pro Pro Lys Gln Pro Lys
85 90 95
Thr Phe Leu Gln Leu Val Trp Glu Ala Leu Gln Asp Val Thr Leu Ile
100 105 110
Ile Leu Glu Val Ala Ala Ile Val Ser Leu Gly Leu Ser Phe Tyr Ala
115 120 125
Pro Pro Gly Glu Glu Ser Glu Ala Cys Gly Asn Val Ser Ala Gly Ala
130 135 140
Glu Asp Glu Gly Glu Ala Glu Ala Gly Trp Ile Glu Gly Ala Ala Ile
145 150 155 160
Leu Leu Ser Val Ile Cys Val Val Leu Val Thr Ala Phe Asn Asp Trp
165 170 175
Ser Lys Glu Lys Gln Phe Arg Gly Leu Gln Ser Arg Ile Glu Gln Glu
180 185 190
Gln Lys Phe Thr Val Ile Arg Asn Gly Gln Leu Leu Gln Val Pro Val
195 200 205
Ala Thr Leu Val Val Gly Asp Ile Ala Gln Val Lys Tyr Gly Asp Leu
210 215 220
Leu Pro Ala Asp Gly Val Leu Ile Gln Gly Asn Asp Leu Lys Ile Asp
225 230 235 240
Glu Ser Ser Leu Thr Gly Glu Ser Asp His Val Arg Lys Ser Thr Asp
245 250 255
Lys Asp Pro Met Leu Leu Ser Gly Thr His Val Met Glu Gly Ser Gly
260 265 270
Arg Met Val Val Thr Ala Val Gly Val Asn Ser Gln Thr Gly Ile Ile
275 280 285
Phe Thr Leu Leu Gly Ala Gly Gly Glu Glu Glu Glu Lys Lys Asp Lys
290 295 300
Lys Gly Lys Gln Gln Asp Gly Ala Met Glu Ser Ser Gln Thr Lys Ala
305 310 315 320
Lys Lys Gln Asp Gly Ala Val Ala Met Glu Met Gln Pro Leu Lys Ser
325 330 335
Ala Glu Gly Gly Glu Met Glu Glu Arg Glu Lys Lys Lys Ala Asn Val
340 345 350
Pro Lys Lys Glu Lys Ser Val Leu Gln Gly Lys Leu Thr Lys Leu Ala
355 360 365
Val Gln Ile Gly Lys Ala Gly Leu Val Met Ser Ala Ile Thr Val Ile
370 375 380
Ile Leu Val Leu Tyr Phe Val Ile Glu Thr Phe Val Ile Asp Gly Arg
385 390 395 400
Met Trp Leu Ala Glu Cys Thr Pro Val Tyr Val Gln Tyr Phe Val Lys
405 410 415
Phe Phe Ile Ile Gly Val Thr Val Leu Val Val Ala Val Pro Glu Gly
420 425 430
Leu Pro Leu Ala Val Thr Ile Ser Leu Ala Tyr Ser Val Lys Lys Met
435 440 445
Met Arg Asp Asn Asn Leu Val Arg His Leu Asp Ala Cys Glu Thr Met
450 455 460
Gly Asn Ala Thr Ala Ile Cys Ser Asp Lys Thr Gly Thr Leu Thr Thr
465 470 475 480
Asn Arg Met Thr Val Val Gln Ser Tyr Leu Gly Asp Thr His Tyr Lys
485 490 495
Glu Val Pro Ala Pro Ser Ala Leu Thr Pro Lys Ile Leu Asp Ile Leu
500 505 510
Val His Ala Ile Ser Ile Asn Ser Ala Tyr Thr Thr Lys Ile Leu Pro
515 520 525
Pro Glu Lys Glu Gly Ala Leu Pro Arg Gln Val Gly Asn Lys Thr Glu
530 535 540
Cys Ala Leu Leu Gly Phe Val Leu Asp Leu Lys Arg Asp Phe Gln Pro
545 550 555 560
Val Arg Glu Gln Ile Pro Glu Asp Lys Leu Tyr Lys Val Tyr Thr Phe
565 570 575
Asn Ser Val Arg Lys Ser Met Ser Thr Val Ile Arg Thr Pro Asp Gly
580 585 590
Gly Phe Arg Leu Phe Ser Lys Gly Ala Ser Glu Ile Leu Leu Lys Lys
595 600 605
Cys Thr Asn Ile Leu Asn Ser Asn Gly Glu Leu Arg Ser Phe Arg Pro
610 615 620
Arg Asp Arg Asp Asp Met Val Lys Lys Ile Ile Glu Pro Met Ala Cys
625 630 635 640
Asp Gly Leu Arg Thr Ile Cys Ile Ala Tyr Arg Asp Phe Thr Ala Ala
645 650 655
Gln Glu Pro Asp Trp Asp Asn Glu Asn Glu Val Val Gly Asp Leu Thr
660 665 670
Cys Ile Ala Val Val Gly Ile Glu Asp Pro Val Arg Pro Glu Val Pro
675 680 685
Glu Ala Ile Arg Lys Cys Gln Arg Ala Gly Ile Thr Val Arg Met Val
690 695 700
Thr Gly Asp Asn Ile Asn Thr Ala Arg Ala Ile Ala Ala Lys Cys Gly
705 710 715 720
Ile Ile Gln Pro Gly Glu Asp Phe Leu Cys Leu Glu Gly Lys Glu Phe
725 730 735
Asn Arg Arg Ile Arg Asn Glu Lys Gly Glu Ile Glu Gln Glu Arg Leu
740 745 750
Asp Lys Val Trp Pro Lys Leu Arg Val Leu Ala Arg Ser Ser Pro Thr
755 760 765
Asp Lys His Thr Leu Val Lys Gly Ile Ile Asp Ser Asn Thr Gly Glu
770 775 780
Gln Arg Gln Val Val Ala Val Thr Gly Asp Gly Thr Asn Asp Gly Pro
785 790 795 800
Ala Leu Lys Lys Ala Asp Val Gly Phe Ala Met Gly Ile Ala Gly Thr
805 810 815
Asp Val Ala Lys Glu Ala Ser Asp Ile Ile Leu Thr Asp Asp Asn Phe
820 825 830
Thr Ser Ile Val Lys Ala Val Met Trp Gly Arg Asn Val Tyr Asp Ser
835 840 845
Ile Ser Lys Phe Leu Gln Phe Gln Leu Thr Val Asn Val Val Ala Val
850 855 860
Ile Val Ala Phe Thr Gly Ala Cys Ile Thr Gln Asp Ser Pro Leu Lys
865 870 875 880
Ala Val Gln Met Leu Trp Val Asn Leu Ile Met Asp Thr Phe Ala Ser
885 890 895
Leu Ala Leu Ala Thr Glu Pro Pro Thr Glu Ser Leu Leu Leu Arg Lys
900 905 910
Pro Tyr Gly Arg Asp Lys Pro Leu Ile Ser Arg Thr Met Met Lys Asn
915 920 925
Ile Leu Gly His Ala Val Tyr Gln Leu Thr Ile Ile Phe Thr Leu Leu
930 935 940
Phe Val Gly Glu Leu Phe Phe Asp Ile Asp Ser Gly Arg Asn Ala Pro
945 950 955 960
Leu His Ser Pro Pro Ser Glu His Tyr Thr Ile Ile Phe Asn Thr Phe
965 970 975
Val Met Met Gln Leu Phe Asn Glu Ile Asn Ala Arg Lys Ile His Gly
980 985 990
Glu Arg Asn Val Phe His Gly Ile Phe Ser Asn Pro Ile Phe Cys Thr
995 1000 1005
Ile Val Leu Gly Thr Phe Ala Ile Gln Ile Val Ile Val Gln Phe Gly
1010 1015 1020
Gly Lys Pro Phe Ser Cys Ser Pro Leu Ser Thr Glu Gln Trp Leu Trp
1025 1030 1035 1040
Cys Leu Phe Val Gly Ile Gly Glu Leu Val Trp Gly Gln Val Ile Ala
1045 1050 1055
Thr Ile Pro Thr Ser Gln Leu Lys Cys Leu Lys Glu Ala Gly His Gly
1060 1065 1070
Pro Gly Lys Asp Glu Met Thr Asp Glu Glu Leu Ala Glu Gly Glu Glu
1075 1080 1085
Glu Ile Asp His Ala Glu Arg Glu Leu Arg Arg Gly Gln Ile Leu Trp
1090 1095 1100
Phe Arg Gly Leu Asn Arg Ile Gln Thr Gln Ile Arg Val Val Lys Ala
1105 1110 1115 1120
Phe Arg Ser Ser Leu Tyr Glu Gly Leu Glu Lys Pro Glu Ser Lys Thr
1125 1130 1135
Ser Ile His Asn Phe Met Ala Thr Pro Glu Phe Leu Ile Asn Asp Tyr
1140 1145 1150
Thr His Asn Ile Pro Leu Ile Asp Asp Thr Asp Val Asp Glu Asn Glu
1155 1160 1165
Glu Arg Leu Arg Ala Pro Pro Pro Pro Ser Pro Asn Gln Asn Asn Asn
1170 1175 1180
Ala Ile Asp Ser Gly Val Tyr Leu Thr Thr His Gly Thr Lys Ser Ala
1185 1190 1195 1200
Thr Ser Ser Leu Phe Ser Ser Arg Pro Gly Ser Pro Leu His Ser Val
1205 1210 1215
Glu Thr Ser Leu
1220
<210>2
<211>399
<212>PRT
<213>牛
<400>2
Met Ser Gln Arg Gln Pro Gln Ser Pro Asn Gln Thr Leu Ile Ser Thr
1 5 10 15
Thr Asn Asp Thr Glu Leu Ser Ser Ser Val Val Pro Asn Asp Ser Thr
20 25 30
Asn Lys Arg Arg Thr Gly Asp Asn Ser Pro Gly Ile Glu Ala Leu Cys
35 40 45
Ala Ile Tyr Ile Thr Tyr Ala Val Ile Ile Ser Val Gly Ile Leu Gly
50 55 60
Asn Ala Ile Leu Ile Lys Val Phe Phe Lys Thr Lys Ser Met Gln Thr
65 70 75 80
Val Pro Asn Ile Phe Ile Thr Ser Leu Ala Phe Gly Asp Leu Leu Leu
85 90 95
Leu Leu Thr Cys Val Pro Val Asp Ala Thr His Tyr Leu Ala Glu Gly
100 105 110
Trp Leu Phe Gly Arg Ile Gly Cys Lys Val Leu Ser Phe Ile Arg Leu
115 120 125
Thr Ser Val Gly Val Ser Val Phe Thr Leu Thr Ile Leu Ser Ala Asp
130 135 140
Arg Tyr Lys Ala Val Val Lys Pro Leu Glu Arg Gln Pro Pro Asn Ala
145 150 155 160
Ile Leu Lys Thr Cys Ala Lys Ala Gly Cys Ile Trp Ile Met Ser Met
165 170 175
Ile Ile Ala Leu Pro Glu Ala Ile Phe Ser Asn Val Tyr Thr Phe Gln
180 185 190
Asp Pro Asp Lys Asn Val Thr Phe Lys Val Cys Ala Ser Tyr Pro Val
195 200 205
Ser Glu Arg Leu Leu Gln Glu Ile His Ser Leu Leu Cys Phe Leu Val
210 215 220
Phe Tyr Ile Ile Pro Leu Ser Ile Ile Ser Val Tyr Tyr Ser Leu Ile
225 230 235 240
Ala Arg Thr Leu Tyr Lys Ser Thr Leu Asn Ile Pro Thr Glu Glu Gln
245 250 255
Ser His Ala Arg Lys Gln Ile Glu Ser Arg Lys Arg Ile Ala Arg Thr
260 265 270
Val Leu Val Leu Val Ala Leu Phe Ala Leu Cys Trp Leu Pro Asn His
275 280 285
Leu Leu Tyr Leu Tyr Arg Ser Phe Thr Ser Gln Asn Tyr Thr Asp Ser
290 295 300
Ser Thr Val His Leu Ile Val Thr Ile Ile Ser Arg Ile Leu Ala Phe
305 310 315 320
Ser Asn Ser Cys Val Asn Pro Phe Ala Leu Tyr Trp Leu Ser Asn Thr
325 330 335
Phe Gln Gln His Phe Lys Ala Gln Leu Phe Cys Cys Lys Ala Gly Val
340 345 350
Pro Asp Ala Ser Ala Ala Asn Thr Pro Leu Asp Asn Leu Ala Val Met
355 360 365
Gly Arg Val Pro Gly Ala Ala Ser Thr Gln Met Ser Glu Ile Ser Val
370 375 380
Ser Leu Phe Thr Gly Cys Ser Val Lys Lys Glu Asp Asp Arg Val
385 390 395
<210>3
<211>150
<212>PRT
<213>牛
<400>3
Pro Gln Ile Gly Gly Arg Gly Arg Asn Gly Asp Glu Ser Cys Ser Arg
1 5 10 15
Ala Leu Arg Gly Arg Pro Gln His Arg Pro Pro Arg Arg Thr Met Leu
20 25 30
Arg Gly Lys Ser Arg Leu Asn Val Glu Trp Leu Gly Tyr Ser Pro Gly
35 40 45
Leu Leu Leu Glu Arg Arg Pro Leu Leu Ala Gly Arg Thr Pro Arg Ser
50 55 60
Pro Gly Arg Asn Glu Ser Ser Leu Ala Ser Thr Leu Lys Thr Leu Leu
65 70 75 80
Phe Phe Thr Ala Leu Met Ile Thr Val Pro Ile Gly Leu Tyr Phe Thr
85 90 95
Thr Lys Ser Tyr Val Phe Glu Gly Ala Phe Gly Met Ser Asn Arg Asp
100 105 110
Ser Tyr Phe Tyr Ala Ala Ile Val Ala Val Val Ala Val His Val Val
115 120 125
Leu Ala Leu Phe Val Tyr Val Ala Trp Asn Glu Gly Ser Arg Gln Trp
130 135 140
Arg Glu Gly Lys Gln Asp
145 150
<210>4
<211>346
<212>PRT
<213>牛
<400>4
Gly Leu Phe Gln Asp Phe Asn Pro Ser Lys Phe Leu Ile Tyr Ala Cys
1 5 10 15
Leu Leu Leu Phe Ser Val Leu Leu Ala Leu Arg Leu Asp Gly Ile Ile
20 25 30
Gln Trp Ser Tyr Trp Ala Val Phe Ala Pro Ile Trp Leu Trp Lys Leu
35 40 45
Met Val Ile Val Gly Ala Ser Val Gly Thr Gly Val Trp Ala Arg Asn
50 55 60
Pro Gln Tyr Arg Ala Glu Gly Glu Thr Cys Val Glu Phe Lys Ala Met
65 70 75 80
Leu Ile Ala Val Gly Ile His Leu Leu Leu Leu Met Phe Glu Val Leu
85 90 95
Val Cys Asp Arg Ile Glu Arg Gly Ser His Phe Trp Leu Leu Val Phe
100 105 110
Met Pro Leu Phe Phe Val Ser Pro Val Ser Val Ala Ala Cys Val Trp
115 120 125
Gly Phe Arg His Asp Arg Ser Leu Glu Leu Glu Ile Leu Cys Ser Val
130 135 140
Asn Ile Leu Gln Phe Ile Phe Ile Ala Leu Arg Leu Asp Lys Ile Ile
145 150 155 160
His Trp Pro Trp Leu Val Val Cys Val Pro Leu Trp Ile Leu Met Ser
165 170 175
Phe Leu Cys Leu Val Val Leu Tyr Tyr Ile Val Trp Ser Val Leu Phe
180 185 190
Leu Arg Ser Met Asp Val Ile Ala Glu Gln Arg Arg Thr His Ile Thr
195 200 205
Met Ala Leu Ser Trp Met Thr Ile Val Val Pro Leu Leu Thr Phe Glu
210 215 220
Ile Leu Leu Val His Lys Leu Asp Gly His Asn Ala Phe Ser Cys Ile
225 230 235 240
Pro Ile Phe Val Pro Leu Trp Leu Ser Leu Ile Thr Leu Met Ala Thr
245 250 255
Thr Phe Gly Gln Lys Gly Gly Asn His Trp Trp Phe Gly Ile Arg Lys
260 265 270
Asp Phe Cys Gln Phe Leu Leu Glu Ile Cys Pro Phe Leu Arg Glu Tyr
275 280 285
Gly Asn Ile Ser Tyr Asp Leu His His Glu Gly Ser Glu Glu Thr Glu
290 295 300
Glu Thr Pro Val Pro Glu Pro Pro Lys Ile Ala Pro Met Phe Arg Lys
305 310 315 320
Lys Thr Arg Val Val Ile Thr Gln Ser Pro Gly Lys Tyr Val Leu Pro
325 330 335
Pro Pro Lys Leu Asn Ile Glu Met Pro Asp
340 345
<210>5
<211>382
<212>PRT
<213>牛
<400>5
Met Gly Leu Thr Phe Trp Lys Val Phe Leu Ile Leu Asn Cys Leu Ala
1 5 10 15
Gly Gln Val Asn Gly Val Gln Val Thr Ile Pro Asp Ser Phe Val Asn
20 25 30
Val Thr Val Gly Ser Asp Val Thr Leu Ile Cys Thr Tyr Ala Thr Thr
35 40 45
Val Ala Ser Leu Asn Lys Leu Ser Ile Gln Trp Thr Phe Phe His Lys
50 55 60
Glu Ala Ser Gln Pro Val Ser Ile Tyr Tyr Ser Glu Gly Gly Gln Ala
65 70 75 80
Thr Ala Ile Gly Lys Phe Lys Asp Arg Ile Val Gly Ser Asn Thr Ser
85 90 95
Gly Asn Ala Ser Ile Thr Ile Ser His Met Gln Pro Glu Asp Ser Gly
100 105 110
Ile Tyr Ile Cys Asp Val Asn Asn Pro Pro Asp Phe Phe Gly Lys Asn
115 120 125
Gln Gly Thr Ile Ser Val Ser Val Leu Val Lys Pro Ser Lys Pro Phe
130 135 140
Cys Ser Ile Gln Gly Ile Ala Glu Thr Gly His Pro Ile Ser Leu Thr
145 150 155 160
Cys Leu Ser Val Leu Gly Thr Pro Ser Pro Val Tyr Tyr Trp Tyr Lys
165 170 175
Leu Glu Gly Arg Asn Ile Val Pro Val Lys Glu Asn Phe Asn Pro Ala
180 185 190
Thr Gly Ile Leu Phe Ile Gly Asn Leu Thr Thr Phe Glu Gln Gly Tyr
195 200 205
Tyr Gln Cys Thr Ala Ile Asn Ile Leu Gly Asn Ser Ser Cys Glu Ile
210 215 220
Asp Leu Thr Thr Pro Tyr Pro Gly Ile Gly Ile Ile Val Gly Ala Phe
225 230 235 240
Val Gly Thr Leu Ile Gly Val Ile Ile Ile Ile Ser Val Val Trp Phe
245 250 255
Val Arg Arg Lys Val Lys Ala Lys Gly Lys Glu Arg Lys Arg Asn Ser
260 265 270
Lys Thr Thr Thr Glu Leu Glu Pro Met Thr Lys Ile Asn Gln Arg Thr
275 280 285
Glu Gly Glu Thr Met Pro Arg Glu Asp Ala Ile Gln Leu Glu Ala Thr
290 295 300
Leu Pro Ser Ser Thr His Glu Thr Glu Pro Asn Ala Thr Leu Gly Pro
305 310 315 320
Asp His Glu Pro Ile Pro Glu Pro Glu Pro Ala Leu Gln Pro Thr Val
325 330 335
Glu Pro Pro Ser Gly Pro Glu Leu Val Pro Met Ser Glu Leu Glu Ile
340 345 350
Gln Leu Glu Pro Glu Pro Ala Pro Gln Gln Glu Pro Glu Pro Leu Ile
355 360 365
Val Asp Glu Pro Phe Cys Asp Glu Glu Lys Val Ile Lys Pro
370 375 380
<210>6
<211>548
<212>PRT
<213>牛
<400>6
Gly Val Phe Leu Ile Pro Tyr Ile Leu Ile Ala Leu Ile Gly Gly Ile
1 5 10 15
Pro Ile Phe Phe Leu Glu Ile Ser Leu Gly Gln Phe Met Lys Ala Gly
20 25 30
Ser Ile Asn Val Trp Asn Ile Cys Pro Leu Phe Lys Gly Leu Gly Tyr
35 40 45
Ala Ser Met Val Ile Val Phe Tyr Cys Asn Thr Tyr Tyr Ile Met Val
50 55 60
Leu Ala Trp Gly Phe Tyr Tyr Leu Val Lys Ser Phe Thr Thr Thr Leu
65 70 75 80
Pro Trp Ala Thr Cys Gly His Thr Trp Asn Thr Pro Asp Cys Val Glu
85 90 95
Ile Phe Arg His Glu Asp Cys Ala Asn Ala Thr Met Ala Asn Leu Thr
100 105 110
Cys Asp Gln Leu Ala Asp Arg Arg Ser Pro Val Ile Glu Phe Trp Glu
115 120 125
Asn Lys Val Leu Arg Leu Ser Glu Gly Leu Glu Val Pro Gly Ala Leu
130 135 140
Asn Trp Glu Val Thr Leu Cys Leu Leu Thr Cys Trp Val Leu Val Tyr
145 150 155 160
Phe Cys Val Trp Lys Gly Val Lys Ser Thr Gly Lys Ile Val Tyr Phe
165 170 175
Thr Ala Thr Phe Pro Tyr Val Val Leu Val Val Leu Leu Val Arg Gly
180 185 190
Val Leu Leu Pro Gly Ala Leu Asp Gly Ile Ile Tyr Tyr Leu Lys Pro
195 200 205
Asp Trp Ser Lys Leu Ala Ser Pro Gln Val Trp Ile Asp Ala Gly Thr
210 215 220
Gln Ile Phe Phe Ser Tyr Ala Ile Gly Leu Gly Ala Leu Thr Ala Leu
225 230 235 240
Gly Ser Tyr Asn Arg Phe Asn Asn Asn Cys Tyr Lys Asp Ala Ile Ile
245 250 255
Leu Ala Leu Ile Asn Ser Gly Thr Ser Phe Phe Ala Gly Phe Val Val
260 265 270
Phe Ser Ile Leu Gly Phe Met Ala Thr Glu Gln Gly Val His Ile Ser
275 280 285
Lys Val Ala Glu Ser Gly Pro Gly Leu Ala Phe Ile Ala Tyr Pro Arg
290 295 300
Ala Val Thr Leu Met Pro Val Ala Pro Leu Trp Ala Ala Leu Phe Phe
305 310 315 320
Phe Met Leu Leu Leu Leu Gly Leu Asp Ser Gln Phe Val Gly Val Glu
325 330 335
Gly Phe Ile Thr Gly Leu Leu Asp Leu Leu Pro Ala Ser Tyr Tyr Phe
340 345 350
Arg Phe Gln Arg Glu Ile Ser Val Ala Leu Cys Cys Thr Ile Cys Phe
355 360 365
Val Ile Asp Leu Ser Met Val Thr Asp Gly Gly Met Tyr Val Phe Gln
370 375 380
Leu Phe Asp Tyr Tyr Ser Ala Ser Gly Thr Thr Leu Leu Trp Gln Ala
385 390 395 400
Phe Trp Glu Cys Val Val Val Ala Trp Val Tyr Gly Ala Asp Arg Phe
405 410 415
Met Asp Asp Val Ala Cys Met Ile Gly Tyr Arg Pro Cys Pro Trp Met
420 425 430
Lys Trp Cys Trp Ser Phe Phe Thr Pro Leu Val Cys Met Gly Ile Phe
435 440 445
Ile Phe Asn Val Val Tyr His Glu Pro Leu Val Tyr Asn Asn Thr Tyr
450 455 460
Val Tyr Pro Trp Trp Gly Glu Ala Val Gly Trp Ala Phe Ala Leu Ser
465 470 475 480
Ser Met Leu Cys Val Pro Leu His Leu Leu Gly Cys Leu Leu Arg Ala
485 490 495
Lys Gly Thr Met Ala Glu Arg Trp Gln His Leu Thr Gln Pro Ile Trp
500 505 510
Gly Leu His His Leu Glu Tyr Arg Ala Gln Asp Ser Asp Val Arg Gly
515 520 525
Leu Thr Thr Leu Thr Pro Val Ser Glu Ser Ser Lys Val Val Val Val
530 535 540
Glu Ser Val Met
545
<210>7
<211>1504
<212>PRT
<213>牛
<400>7
Glu Glu Ile Lys Met Asp Leu Ser Val Ser Val Asn Ser Val Thr Ile
1 5 10 15
Ser Val Glu Gly Met Thr Cys Ser Ser Cys Val Trp Thr Ile Glu Gln
20 25 30
Gln Ile Gly Lys Leu Asn Gly Val His His Ile Lys Val Ser Leu Glu
35 40 45
Glu Lys Asn Ala Thr Val Ile Tyr Asp Pro Lys Leu Gln Thr Pro Lys
50 55 60
Thr Leu Gln Glu Ala Ile Asp Asp Met Gly Phe Asp Ala Ile Leu His
65 70 75 80
Asn Pro Lys Pro Leu Pro Val Leu Thr Glu Thr Val Phe Leu Thr Val
85 90 95
Thr Ala Ser Leu Val Pro Pro Trp Asp His Ile Gln Ser Thr Leu Leu
100 105 110
Lys Thr Lys Gly Val Thr Asp Ile Lys Ile Ser Pro Gln Gln Arg Thr
115 120 125
Ala Val Val Thr Ile Ile Pro Ser Ile Val Asn Ala Asn Gln Ile Val
130 135 140
Glu Leu Val Pro Asp Leu Ser Leu Asp Thr Gly Thr Leu Glu Lys Lys
145 150 155 160
Ser Gly Thr Cys Glu Asp Tyr Ser Met Ala Gln Pro Gly Glu Val Met
165 170 175
Leu Lys Met Lys Val Glu Gly Met Thr Cys His Ser Cys Thr Ser Thr
180 185 190
Ile Glu Gly Lys Ile Gly Lys Leu Gln Gly Val Gln Arg Ile Lys Val
195 200 205
Ser Leu Asp Asn Gln Glu Ala Thr Val Val Tyr Gln Pro His Leu Ile
210 215 220
Thr Ala Glu Glu Ile Lys Lys Gln Ile Glu Val Val Gly Phe Thr Ala
225 230 235 240
Phe Ile Lys Lys Gln Pro Lys Tyr Leu Lys Leu Gly Ala Ile Asp Ile
245 250 255
Glu Arg Leu Lys Asn Thr Pro Val Lys Ser Ser Glu Gly Ser Gln Gln
260 265 270
Lys Ser Pro Ser Tyr Thr Ser Asn Ser Thr Val Ile Phe Thr Ile Asp
275 280 285
Gly Met His Cys Lys Ser Cys Val Ser Asn Ile Glu Ser Ala Leu Ser
290 295 300
Thr Leu Gln His Ile Ser Ser Val Val Val Ser Leu Glu Asn Lys Ser
305 310 315 320
Ala Ile Val Lys Tyr Asn Ala Ser Leu Val Thr Pro Glu Thr Leu Arg
325 330 335
Lys Ala Ile Glu Ala Ile Ser Gln Gly Gln Tyr Arg Val Ser Ser Ala
340 345 350
Ser Glu Ile Glu Ser Thr Ser Asn Ser Pro Ser Ser Ser Ser Leu Gln
355 360 365
Lys Ser Pro Leu Asn Ile Val Ser Gln Pro Leu Thr Gln Glu Thr Val
370 375 380
Ile Asn Ile Asp Gly Met Thr Cys Asn Ser Cys Val Gln Ser Ile Glu
385 390 395 400
Gly Val Ile Ser Lys Lys Ala Gly Val Lys Ser Ile Gln Val Ser Leu
405 410 415
Ala Asn Gly Lys Gly Thr Val Glu Tyr Asp Pro Leu Leu Thr Ser Pro
420 425 430
Glu Thr Leu Arg Glu Ala Ile Glu Asn Met Gly Phe Asp Ala Ser Leu
435 440 445
Ser Asp Thr Asn Glu Pro Leu Val Val Ile Ala Gln Pro Ser Ser Glu
450 455 460
Met Pro Leu Leu Thr Ser Thr Asn Glu Phe His Thr Lys Met Met Thr
465 470 475 480
Pro Ile His Asp Lys Glu Glu Pro Lys Thr Ser Ser Lys Cys Tyr Ile
485 490 495
Gln Val Thr Gly Met Thr Cys Ala Ser Cys Val Ala Asn Ile Glu Arg
500 505 510
Asn Leu Arg Arg Glu Glu Gly Ile Tyr Ser Ile Leu Val Ala Leu Met
515 520 525
Ala Gly Lys Ala Glu Val Arg Tyr Asn Pro Ala Leu Ile Gln Pro Pro
530 535 540
Val Ile Ala Glu Leu Ile Arg Glu Leu Gly Phe Gly Ser Thr Val Ile
545 550 555 560
Glu Asn Ala Asp Glu Gly Asp Gly Val Leu Glu Leu Val Val Arg Gly
565 570 575
Met Thr Cys Ala Ser Cys Val His Lys Ile Glu Ser Thr Leu Thr Lys
580 585 590
His Arg Gly Ile Phe Tyr Cys Ser Val Ala Leu Ala Thr Asn Lys Ala
595 600 605
His Ile Lys Tyr Asp Pro Glu Ile Ile Gly Pro Arg Asp Ile Ile His
610 615 620
Thr Ile Glu Ser Leu Gly Phe Glu Ala Ser Leu Val Lys Lys Asp Arg
625 630 635 640
Ser Ala Ser His Leu Asp His Lys Arg Glu Ile Arg Gln Trp Arg Arg
645 650 655
Ala Phe Leu Val Ser Leu Phe Phe Cys Ile Pro Val Met Gly Leu Met
660 665 670
Ile Tyr Met Met Val Met Asp His His Leu Ala Ser Leu Gln His Asn
675 680 685
Gln Asn Met Ser Gln Glu Glu Met Ile Asn Ile His Ser Ser Met Phe
690 695 700
Leu Glu Arg Gln Ile Leu Pro Gly Leu Ser Ile Met Asn Leu Leu Ser
705 710 715 720
Phe Leu Leu Cys Val Pro Val Gln Phe Phe Gly Gly Trp His Phe Tyr
725 730 735
Ile Gln Ala Tyr Lys Ala Leu Lys His Lys Thr Ala Asn Met Asp Val
740 745 750
Leu Ile Val Leu Ala Thr Thr Ile Ala Phe Ala Tyr Ser Leu Val Ile
755 760 765
Leu Leu Val Ala Met Tyr Glu Arg Ala Lys Val Asn Pro Val Thr Phe
770 775 780
Phe Asp Thr Pro Pro Met Leu Phe Val Phe Ile Ala Leu Gly Arg Trp
785 790 795 800
Leu Glu His Val Ala Lys Gly Lys Thr Ser Glu Ala Leu Ala Lys Leu
805 810 815
Ile Ser Leu Gln Ala Thr Glu Ala Thr Ile Val Thr Leu Asp Ser Asp
820 825 830
Asn Ile Leu Leu Ser Glu Glu Gln Val Asp Val Glu Leu Val Gln Arg
835 840 845
Gly Asp Ile Ile Lys Val Val Pro Gly Gly Lys Phe Pro Val Asp Gly
850 855 860
Arg Val Ile Glu Gly His Ser Met Val Asp Glu Ser Leu Ile Thr Gly
865 870 875 880
Glu Ala Met Pro Val Ala Lys Lys Ser Gly Ser Thr Val Ile Ala Gly
885 890 895
Ser Ile Asn Gln Asn Gly Ser Leu Leu Ile Arg Ala Thr His Val Gly
900 905 910
Ala Asp Thr Thr Leu Ser Gln Ile Val Lys Leu Val Glu Glu Ala Gln
915 920 925
Thr Ser Lys Ala Pro Ile Gln Gln Phe Ala Asp Lys Leu Ser Gly Tyr
930 935 940
Phe Val Pro Phe Ile Val Ile Val Ser Ile Ala Thr Leu Leu Val Trp
945 950 955 960
Ile Ile Ile Gly Phe Leu Asn Phe Glu Ile Val Glu Thr Tyr Phe Pro
965 970 975
Gly Tyr Asn Arg Ser Ile Ser Arg Thr Glu Thr Ile Ile Arg Phe Ala
980 985 990
Phe Gln Ala Ser Ile Thr Val Leu Cys Ile Ala Cys Pro Cys Ser Leu
995 1000 1005
Gly Leu Ala Thr Pro Thr Ala Val Met Val Gly Thr Gly Val Gly Ala
1010 1015 1020
Gln Asn Gly Ile Leu Ile Lys Gly Gly Glu Pro Leu Glu Met Ala His
1025 1030 1035 1040
Lys Val Lys Val Val Val Phe Asp Lys Thr Gly Thr Ile Thr His Gly
1045 1050 1055
Thr Pro Val Val Asn Gln Val Lys Val Leu Val Glu Ser Asn Arg Ile
1060 1065 1070
Ser Arg Asn Lys Ile Leu Ala Ile Val Gly Thr Ala Glu Ser Asn Ser
1075 1080 1085
Glu His Pro Leu Gly Ala Ala Ile Thr Lys Tyr Cys Lys Gln Glu Leu
1090 1095 1100
Asp Thr Glu Thr Leu Gly Thr Cys Ile Asp Phe Gln Val Val Pro Gly
1105 1110 1115 1120
Cys Gly Ile Asn Cys Lys Val Thr Asn Ile Glu Ala Leu Leu His Lys
1125 1130 1135
Asn Asn Trp Lys Ile Glu Glu Asn Asn Ile Lys Asn Ala Ser Leu Val
1140 1145 1150
Gln Ile Asp Glu Ser Asn Glu Gln Ser Ser Thr Ser Ser Ser Met Ile
1155 1160 1165
Ile Asp Ala Gln Phe Ser Asn Ala Leu Asn Ala Gln Gln Tyr Lys Val
1170 1175 1180
Leu Ile Gly Asn Arg Glu Trp Met Ile Arg Asn Gly Leu Ala Ile Asn
1185 1190 1195 1200
Asn Ser Val Asn Asp Ser Met Thr Glu His Glu Arg Arg Gly Arg Thr
1205 1210 1215
Ala Val Leu Val Ala Val Asp Asp Glu Leu Cys Gly Leu Ile Ala Ile
1220 1225 1230
Ala Asp Thr Val Lys Pro Glu Ala Glu Leu Ala Val His Ile Leu Lys
1235 1240 1245
Ser Met Gly Leu Glu Val Val Leu Met Thr Gly Asp Asn Ser Lys Thr
1250 1255 1260
Ala Arg Ser Ile Ala Ser Gln Val Gly Ile Thr Lys Val Phe Ala Glu
1265 1270 1275 1280
Val Leu Pro Ser His Lys Val Ala Lys Val Lys Gln Leu Gln Glu Glu
1285 1290 1295
Gly Lys Arg Val Ala Met Val Gly Asp Gly Ile Asn Asp Ser Pro Ala
1300 1305 1310
Leu Ala Met Ala Asn Val Gly Ile Ala Ile Gly Thr Gly Thr Asp Val
1315 1320 1325
Ala Ile Glu Ala Ala Asp Val Val Leu Ile Arg Asn Asp Leu Leu Asp
1330 1335 1340
Val Val Ala Ser Ile Asp Leu Ser Arg Lys Thr Val Lys Arg Ile Arg
1345 1350 1355 1360
Ile Asn Phe Val Phe Ala Leu Ile Tyr Asn Leu Ile Gly Ile Pro Ile
1365 1370 1375
Ala Ala Gly Val Phe Met Pro Ile Gly Leu Val Leu Gln Pro Trp Met
1380 1385 1390
Gly Ser Ala Ala Met Ala Ala Ser Ser Val Ser Val Val Leu Ser Ser
1395 1400 1405
Leu Phe Leu Lys Leu Tyr Arg Lys Pro Thr Tyr Glu Asn Tyr Glu Leu
1410 1415 1420
His Ala Arg Asn Gln Met Gly Gln Lys Ser Pro Ser Glu Ile Ser Val
1425 1430 1435 1440
His Val Gly Ile Asp Asp Thr Ser Arg Asn Ser Pro Lys Leu Gly Leu
1445 1450 1455
Leu Asp Arg Ile Val Asn Tyr Ser Arg Ala Ser Ile Asn Ser Leu Leu
1460 1465 1470
Ser Asp Lys Arg Ser Leu Asn Ser Val Gly Thr Ser Glu Pro Asp Lys
1475 1480 1485
His Ser Leu Leu Val Gly Asp Cys Arg Glu Asp Asp Asp Ser Ala Leu
1490 1495 1500
<210>8
<211>445
<212>PRT
<213>牛
<400>8
Met Lys Phe Pro Gly Ser Val Leu Ala Ser Val Phe Leu Phe Val Ala
1 5 10 15
Glu Thr Ser Ala Ala Leu Tyr Asn Met Val Ile His Asn Phe Lys Gly
20 25 30
Asn Ala Pro Phe Ile Val Ile Thr Lys Leu Phe Met Leu Thr Pro Thr
35 40 45
Cys Met Val Ser Gly Thr Leu Ile Lys Leu Val Asn His Glu Pro Ser
50 55 60
Arg Gly Arg Gly Leu Cys Asn Leu Glu His Leu Leu Asp Leu Lys Phe
65 70 75 80
Val Ser Arg Cys Phe Glu Val Phe Cys Ile Tyr Cys Gln Ser Asn His
85 90 95
Ile Glu Glu Pro Tyr Val Ser Ile Thr Lys Lys Arg Gln Ile Pro Lys
100 105 110
Asn Gly His Ser Glu Glu Ile Glu Lys Glu Val Gly Gln Ala Glu Gly
115 120 125
Lys Leu Phe Thr His Arg Ser Ala Phe Ser Arg Ala Ser Val Ile Gln
130 135 140
Ala Phe Leu Gly Ser Ala Pro Gln Leu Thr Leu Gln Leu Tyr Ile Ser
145 150 155 160
Val Leu Gln Gln Asp Val Ser Ile Gly Arg Cys Leu Phe Met Val Leu
165 170 175
Ser Leu Leu Ser Ile Val Tyr Gly Ala Leu Arg Cys Asn Ile Leu Ala
180 185 190
Ile Lys Ile Lys Tyr Asp Glu Tyr Asp Val Lys Val Lys Pro Leu Ala
195 200 205
Tyr Val Cys Ile Phe Leu Trp Arg Ser Phe Glu Ile Val Thr Arg Val
210 215 220
Ile Val Leu Val Leu Phe Thr Ser Val Leu Lys Ala Trp Val Val Ile
225 230 235 240
Asp Ile Leu Ile Asn Phe Leu Gly Phe Leu Phe Tyr Pro Trp Ile Leu
245 250 255
Phe Trp Cys Ser Gly Ser Pro Phe Pro Glu Asn Phe Glu Lys Ala Phe
260 265 270
Ser Arg Leu Gly Thr Thr Ile Val Leu Cys Phe Leu Thr Leu Leu Tyr
275 280 285
Ala Gly Ile Asn Met Phe Cys Trp Ser Ala Val Gln Leu Lys Ile Asn
290 295 300
Asn Pro Asp Leu Ile Ser Lys Ser Gln Asn Trp Tyr Arg Leu Leu Val
305 310 315 320
Tyr Tyr Met Val Arg Phe Ile Glu Asn Ala Phe Leu Leu Leu Met Trp
325 330 335
Tyr Leu Tyr Lys Thr Asp Ile Tyr Met Tyr Val Cys Ala Pro Leu Leu
340 345 350
Met Leu Gln Leu Leu Ile Gly Tyr Cys Thr Ala Ile Leu Phe Met Val
355 360 365
Val Phe Tyr Gln Phe Phe His Pro Cys Lys Lys Leu Phe Ser Pro Asn
370 375 380
Ala Ser Glu Ser Phe Gln Glu Trp Leu Lys Cys Ala Cys Cys Asn Arg
385 390 395 400
Arg Arg Arg Glu Ser Cys Glu Ser Ala Glu Asn Thr Asp Leu Arg Ser
405 410 415
Pro Thr Asp Arg Glu Glu Thr Pro Ser Ser Ser Lys Ile Ser Ser Met
420 425 430
Pro Ser Gln Ile Leu Asn Thr Asp Glu Leu Ser Ser Ala
435 440 445
<210>9
<211>1257
<212>PRT
<213>牛
<400>9
Met Ala Val Ala Leu Trp Phe Leu Trp Pro Leu Leu Leu Cys Ser Pro
1 5 10 15
Cys Val Leu Ile Gln Ile Pro Glu Glu Tyr Glu Gly His His Val Met
20 25 30
Glu Pro Pro Ile Ile Thr Glu Gln Ser Pro Arg Arg Val Val Val Phe
35 40 45
Pro Thr Asp Asp Val Ser Leu Lys Cys Glu Ala Ser Gly Lys Pro Glu
50 55 60
Val Gln Phe Arg Trp Thr Arg Asp Gly Ile Leu Phe Lys Pro Arg Glu
65 70 75 80
Glu Leu Gly Met Ile Val Asn Gln Val Pro His Ser Gly Ser Phe Ser
85 90 95
Ile Thr Gly Asn Ser Ser Asn Phe Ala Gln Ser Phe Gln Gly Thr Tyr
100 105 110
Arg Cys Phe Ala Ser Asn Lys Leu Gly Thr Ala Met Ser His Glu Ile
115 120 125
Gln Leu Met Ala Glu Gly Thr Pro Lys Trp Pro Lys Glu Thr Val Lys
130 135 140
Pro Val Glu Val Glu Glu Gly Glu Ser Val Ile Leu Pro Cys His Pro
145 150 155 160
Pro Pro Ser Ala Glu Pro Leu Arg Ile Tyr Trp Met Asn Ser Lys Ile
165 170 175
Leu His Ile Lys Gln Asp Glu Arg Val Thr Met Gly Gln Asn Gly Asn
180 185 190
Leu Tyr Phe Ala Asn Val Leu Thr Ser Asp Asn His Ser Asp Tyr Ile
195 200 205
Cys His Ala His Phe Pro Gly Thr Arg Thr Ile Ile Gln Lys Glu Pro
210 215 220
Ile Asp Leu Arg Val Lys Ala Thr Asn Ser Met Met Asp Arg Lys Pro
225 230 235 240
His Leu Leu Phe Pro Thr Asn Ser Ser Ser His Leu Val Ala Leu Gln
245 250 255
Gly Gln Pro Leu Ile Leu Glu Cys Ile Ala Glu Gly Phe Pro Thr Pro
260 265 270
Thr Ile Lys Trp Leu Arg Pro Ser Gly Pro Met Pro Ala Asp Arg Val
275 280 285
Thr Tyr Gln Asn His Asn Lys Thr Leu Gln Leu Leu Asn Val Gly Glu
290 295 300
Glu Asp Asp Gly Glu Tyr Arg Cys Leu Ala Glu Asn Ser Leu Gly Ser
305 310 315 320
Asp Arg His Ala Tyr Tyr Val Thr Val Glu Ala Ala Pro Tyr Trp Leu
325 330 335
His Lys Pro Gln Ser His Leu Tyr Gly Pro Gly Glu Thr Ala Arg Leu
340 345 350
Asp Cys Gln Val Gln Gly Arg Pro Gln Pro Glu Val Thr Trp Arg Ile
355 360 365
Asn Gly Ile Pro Val Glu Glu Leu Gly Lys Asp Gln Lys Tyr Arg Ile
370 375 380
His His Gly Ala Leu Val Leu Ser Asn Leu Gln Pro Ser Asp Thr Met
385 390 395 400
Val Thr Gln Cys Glu Ala Arg Asn Arg His Gly Leu Leu Leu Ala Asn
405 410 415
Ala Tyr Ile Tyr Val Val Glu Leu Pro Ala Lys Ile Leu Thr Pro Asp
420 425 430
Asn Glu Thr Tyr Met Ala Val Gln Gly Ser Thr Ala Tyr Leu Leu Cys
435 440 445
Lys Ala Phe Gly Ala Pro Val Pro Ser Val Gln Trp Leu Asp Arg Glu
450 455 460
Gly Lys Thr Val Leu Gln Asp Glu Arg Phe Phe Pro Tyr Thr Asn Gly
465 470 475 480
Thr Leu Gly Ile Arg Asp Leu Gln Thr Asn Asp Thr Gly His Tyr Phe
485 490 495
Cys Gln Ala Ala Asn Asp Gln Ser Asn Val Thr Ile Val Ala Asn Leu
500 505 510
Gln Val Lys Asp Ala Thr Arg Ile Met Gln Gly Pro Arg Ser Ala Ile
515 520 525
Glu Lys Arg Gly Ser Arg Val Met Phe Thr Cys Gln Ala Ser Phe Asp
530 535 540
Pro Ser Leu Gln His Ser Thr Thr Trp Arg Arg Asp Ala Leu Asp Leu
545 550 555 560
Gln Glu Leu Gly Asp Ser Asp Lys Tyr Phe Ile Glu Asp Glu Arg Leu
565 570 575
Val Ile His Ser Leu Asp Tyr Ser Asp Gln Gly Asn Tyr Ser Cys Val
580 585 590
Ala Ser Thr Lys Leu Asp Val Val Glu Ser Arg Ala Glu Leu Leu Val
595 600 605
Val Gly Ser Pro Gly Pro Val Pro Gln Leu Glu Leu Ser Asp His His
610 615 620
Leu Leu Lys Gln Ser Gln Val Arg Leu Ser Trp Ser Pro Ala Asp Asp
625 630 635 640
His Asn Ala Pro Ile Glu Lys Tyr Asp Ile Glu Phe Glu Asp Lys Glu
645 650 655
Met Ala Pro Glu Lys Trp Tyr Ser Leu Gly Lys Val Pro Gly Asn Gln
660 665 670
Thr Ser Thr Thr Leu Lys Leu Ser Pro Tyr Val His Tyr Thr Phe Arg
675 680 685
Val Thr Ala Ile Asn Lys Tyr Gly Pro Gly Glu Pro Ser Pro Asp Ser
690 695 700
Glu Thr Val Val Thr Pro Glu Ala Ala Pro Glu Lys Asn Pro Val Asp
705 710 715 720
Val Lys Gly Glu Gly Asn Glu Thr Asn Asn Met Val Ile Thr Trp Lys
725 730 735
Pro Leu Arg Trp Met Asp Trp Asn Ala Pro Gln Val Gln Tyr Arg Val
740 745 750
Gln Trp Arg Pro Gln Lys Met Gln Gly Ala Trp Gln Glu Gln Ile Val
755 760 765
Ser Asp Pro Phe Leu Val Val Ser Asn Thr Ser Thr Phe Val Pro Tyr
770 775 780
Glu Ile Lys Val Gln Thr Val Asn Ser Gln Gly Lys Gly Pro Glu Pro
785 790 795 800
Gln Ile Thr Ile Gly Tyr Ser Gly Glu Asp Tyr Pro Gln Ala Ser Pro
805 810 815
Leu Leu Glu Pro Val Lys Ala Leu Asn Ser Ser Thr Val Leu Val Arg
820 825 830
Trp Gln Ser Val Asp Pro Ala Gln Val Lys Gly His Leu Arg Gly Tyr
835 840 845
Asn Val Thr Tyr Trp Trp Glu Gly Ser Gln Arg Lys His Asn Lys Arg
850 855 860
His Val His Lys Gly His Val Val Val Pro Ala Asn Ala Thr Ser Thr
865 870 875 880
Ile Leu Gly Gly Leu Arg Pro Tyr Ser Ser Tyr Trp Val Glu Val Gln
885 890 895
Ala Phe Asn Gly Arg Gly Leu Gly Pro Ala Ser Gly Met Thr Phe Asn
900 905 910
Thr Pro Glu Gly Val Pro Gly His Pro Glu Ala Leu His Leu Glu Cys
915 920 925
Gln Ser Asp Thr Ser Leu Leu Leu His Trp Gln Pro Pro Leu Ser His
930 935 940
Asn Gly Val Leu Thr Gly Tyr Val Leu Ser Tyr Gln Pro Leu Asn Asp
945 950 955 960
Gly Ser Lys Glu Gln Leu Ser Phe Asp Leu Pro Asp Pro Glu Leu Arg
965 970 975
Thr His Asn Leu Thr Asn Leu Ser Pro Arg Leu Arg Tyr Arg Phe Gln
980 985 990
Leu Gln Ala Thr Thr Arg Glu Gly Pro Gly Glu Ala Ile Val Arg Glu
995 1000 1005
Gly Gly Thr Met Ala Leu Ser Gly Met Pro Asp Phe Gly Asn Ile Ser
1010 1015 1020
Ala Met Ala Gly Glu Asn Tyr Ser Val Val Ser Trp Val Pro Lys Glu
1025 1030 1035 1040
Gly Gln Cys Asn Phe Gly Phe Gln Ile Trp Phe Lys Ala Leu Gly Asp
1045 1050 1055
Glu Lys Leu Val Ala Arg Leu Pro Pro Gln Tyr Val Ser Tyr Asn Gln
1060 1065 1070
Ser Ser Tyr Thr Gln Trp Asp Leu Gln Pro Asp Thr Asp Tyr Glu Ile
1075 1080 1085
Gln Leu Leu Lys Glu Gln Val Leu Leu His Gln Met Ala Val Lys Thr
1090 1095 1100
Asn Gly Thr Gly Arg Val Arg Leu Pro Pro Ala Gly Phe Ala Thr Glu
1105 1110 1115 1120
Gly Trp Phe Ile Gly Phe Ile Ser Ala Ile Val Val Leu Leu Leu Val
1125 1130 1135
Leu Leu Ile Leu Cys Phe Ile Lys Arg Ser Lys Gly Gly Lys Tyr Ser
1140 1145 1150
Val Lys Asp Lys Glu Asp Thr Gln Val Asp Ser Glu Ala Arg Pro Met
1155 1160 1165
Lys Asp Glu Thr Phe Gly Glu Tyr Arg Ser Leu Glu Ser Asp Asn Glu
1170 1175 1180
Glu Lys Ala Phe Gly Ser Ser Gln Pro Ser Leu Asn Gly Asp Ile Lys
1185 1190 1195 1200
Pro Leu Gly Ser Asp Asp Ser Leu Ala Asp Tyr Gly Gly Ser Val Asp
1205 1210 1215
Val Gln Phe Asn Glu Asp Gly Ser Phe Ile Gly Gln Tyr Ser Gly Lys
1220 1225 1230
Lys Glu Lys Glu Val Ala Gly Gly Asn Asp Ser Ser Gly Ala Thr Ser
1235 1240 1245
Pro Ile Asn Pro Ala Gly Thr Leu Glu
1250 1255
<210>10
<211>366
<212>PRT
<213>牛
<400>10
Met Val Pro Glu Met Ser Glu Arg Gln Glu Phe Gln Ala Ser Asp Phe
1 5 10 15
Ala Tyr Leu Leu Glu Asn Ser Ser Tyr Asp Tyr Gly Glu Asn Glu Thr
20 25 30
Tyr Phe Cys Cys Thr Ser Pro Pro Cys Pro Gln Asp Phe Ser Leu Asn
35 40 45
Phe Asp Arg Thr Phe Leu Pro Val Leu Tyr Ser Leu Leu Phe Val Leu
50 55 60
Gly Leu Leu Gly Asn Gly Ile Val Ala Val Val Leu Leu Ser Gln Arg
65 70 75 80
Ala Ala Leu Ser Ser Thr Asp Thr Phe Leu Leu His Leu Ala Val Ala
85 90 95
Asp Ala Leu Leu Val Leu Thr Leu Pro Leu Trp Ala Val Asp Ala Ala
100 105 110
Ile Gln Trp Val Phe Gly Ser Gly Leu Cys Lys Val Ala Gly Ala Leu
115 120 125
Phe Asn Ile Asn Phe Tyr Ala Gly Ala Leu Leu Leu Ala Cys Ile Ser
130 135 140
Phe Asp Arg Tyr Leu Ser Ile Val His Ala Thr Gln Leu Tyr Arg Arg
145 150 155 160
Gly Pro Pro Thr Arg Val Ala Leu Thr Cys Val Ala Val Trp Gly Leu
165 170 175
Cys Leu Leu Phe Ala Leu Pro Asp Phe Ile Phe Leu Ser Ser His His
180 185 190
Asp Asn Arg Leu Asn Ala Thr His Cys Gln Tyr Asn Phe Pro Gln Glu
195 200 205
Gly His Thr Ala Leu Arg Ile Leu Gln Leu Val Ala Gly Phe Leu Leu
210 215 220
Pro Leu Leu Val Met Ala Tyr Cys Tyr Ala Arg Ile Leu Ala Val Leu
225 230 235 240
Leu Val Ser Arg Gly Gln Arg Arg Leu Arg Ala Met Arg Leu Val Val
245 250 255
Val Val Val Val Ala Phe Ala Leu Cys Trp Thr Pro Tyr His Leu Val
260 265 270
Val Leu Val Asp Thr Leu Met Asp Leu Gly Ala Leu Ala Arg Asn Cys
275 280 285
Gly Arg Glu Ser Ser Val Asp Ile Ala Lys Ser Val Thr Ser Gly Met
290 295 300
Gly Tyr Met His Cys Cys Leu Asn Pro Leu Leu Tyr Ala Phe Val Gly
305 310 315 320
Val Lys Phe Arg Glu Arg Met Trp Val Leu Leu Val Arg Leu Gly Cys
325 330 335
Pro Asp Gln Arg Cys His Gln Arg Gln Pro Ser Ala Ser Arg Arg Glu
340 345 350
Ser Ser Trp Ser Glu Thr Thr Glu Ala Ser Tyr Ser Gly Leu
355 360 365
<210>11
<211>802
<212>PRT
<213>牛
<400>11
Glu Lys Leu Ile Cys Phe Pro Leu Ser Leu Gly Gln Cys Ala Gly Glu
1 5 10 15
Glu Lys Arg Val Gly Thr Arg Thr Val Phe Val Gly Asn His Pro Val
20 25 30
Ser Glu Thr Glu Ala Tyr Ile Ala Gln Lys Phe Cys Asp Asn Arg Ile
35 40 45
Ile Ser Ser Lys Tyr Thr Leu Trp Asn Phe Leu Pro Lys Asn Leu Phe
50 55 60
Glu Gln Phe Arg Arg Ile Ala Asn Phe Tyr Phe Leu Ile Ile Phe Leu
65 70 75 80
Ile Gln Val Thr Val Asp Thr Pro Thr Ser Pro Ile Thr Ser Gly Leu
85 90 95
Pro Leu Phe Phe Val Ile Thr Val Thr Ala Ile Lys Gln Gly Tyr Glu
100 105 110
Asp Trp Leu Arg His Arg Ala Asp Asn Glu Val Asn Lys Ser Thr Val
115 120 125
Tyr Ile Ile Glu Asn Ala Lys Arg Val Lys Lys Glu Ser Glu Lys Ile
130 135 140
Lys Val Gly Asp Ile Val Glu Val Gln Ala Asp Glu Thr Phe Pro Cys
145 150 155 160
Asp Leu Ile Leu Leu Ser Ser Cys Thr Val Asp Gly Thr Cys Tyr Val
165 170 175
Thr Thr Ala Ser Leu Asp Gly Glu Ser Asn Cys Lys Thr His Tyr Ala
180 185 190
Val Arg Asp Thr Ile Glu Leu Arg Thr Val Glu Ser Ile Asp Asn Leu
195 200 205
Arg Ala Ala Ile Glu Cys Glu Gln Pro Gln Pro Asp Leu Tyr Lys Phe
210 215 220
Val Gly Arg Ile Asn Ile Tyr Ser Asn Ser Ile Glu Ala Val Ala Arg
225 230 235 240
Ser Leu Gly Pro Glu Asn Leu Leu Leu Lys Gly Ala Thr Leu Lys Asn
245 250 255
Thr Lys Lys Ile Tyr Gly Val Ala Val Tyr Thr Gly Met Glu Thr Lys
260 265 270
Met Ala Leu Asn Tyr Gln Gly Lys Ser Gln Lys Arg Ser Ala Val Glu
275 280 285
Lys Ser Ile Asn Ala Phe Leu Ile Val Tyr Leu Phe Ile Leu Leu Thr
290 295 300
Lys Ala Ala Ile Cys Thr Thr Leu Lys Tyr Val Trp Gln Ser Thr Pro
305 310 315 320
His Asn Asp Glu Pro Trp Tyr Asn Gln Lys Thr Gln Lys Glu Arg Glu
325 330 335
Thr Trp Lys Val Leu Lys Met Phe Thr Asp Phe Leu Ser Phe Met Val
340 345 350
Leu Phe Asn Phe Ile Ile Pro Val Ser Met Tyr Val Thr Val Glu Met
355 360 365
Gln Lys Phe Leu Gly Ser Phe Phe Ile Ser Trp Asp Asn Asp Phe Tyr
370 375 380
Asp Glu Glu Ile Asn Glu Gly Ala Leu Val Asn Thr Ser Asp Leu Asn
385 390 395 400
Glu Glu Leu Gly Gln Val Asp Tyr Val Phe Thr Asp Lys Thr Gly Thr
405 410 415
Leu Thr Glu Asn Thr Met Glu Phe Ile Glu Cys Cys Ile Asp Gly His
420 425 430
Lys Tyr Lys Gly Val Ala Gln Glu Thr Asp Gly Leu Ser Gln Thr Asp
435 440 445
Gly Pro Leu Pro Tyr Leu Asp Arg Ala Asp Lys Asn Arg Glu Glu Leu
450 455 460
Phe Leu Arg Ala Leu Cys Leu Cys His Thr Val Glu Val Lys Pro Asn
465 470 475 480
Asp Thr Val Asp Gly Val Thr Glu Ser Ser Glu Leu Thr Tyr Met Ser
485 490 495
Ser Ser Pro Asp Glu Ile Glu Ser Glu Ile Thr Gly Gly Gln Arg Tyr
500 505 510
Gly Phe Thr Phe Val Gly Val Gln Asn Gly Tyr Met Arg Val Glu Asn
515 520 525
Gln Arg Lys Glu Ile Glu Glu Tyr Glu Leu Leu His Thr Leu Asn Phe
530 535 540
Asp Ala Val Arg Arg Arg Met Ser Val Ile Val Lys Thr Gln Thr Gly
545 550 555 560
Asp Ile Leu Leu Phe Cys Lys Gly Ala Asp Ser Ala Val Phe Pro Arg
565 570 575
Val Gln Asn His Glu Ile Asp Leu Ile Lys Val His Val Glu His Asn
580 585 590
Ala Met Glu Gly Tyr Arg Thr Leu Cys Ile Ala Phe Lys Glu Ile Ala
595 600 605
Pro Asp Asp Tyr Glu Arg Val Asn Arg Gln Leu Ile Glu Ala Lys Met
610 615 620
Ala Leu Gln Asp Arg Glu Glu Lys Met Glu Lys Val Phe Asp Glu Ile
625 630 635 640
Glu Thr Asp Met His Leu Ile Gly Ala Thr Ala Val Glu Asp Lys Leu
645 650 655
Gln Asp Gln Ala Ala Glu Thr Ile Glu Ala Leu His Ala Ala Gly Leu
660 665 670
Lys Val Trp Val Leu Thr Gly Asp Lys Met Glu Thr Ala Lys Ser Thr
675 680 685
Cys Tyr Ala Cys Arg Leu Phe Gln Thr Asn Thr Glu Leu Leu Glu Leu
690 695 700
Thr Thr Lys Thr Ile Glu Glu Ser Glu Arg Lys Glu Asp Arg Leu His
705 710 715 720
Glu Leu Leu Thr Glu Tyr Arg Lys Lys Leu Leu His Glu Phe Pro Lys
725 730 735
Ser Thr Arg Ser Leu Lys Lys Ala Trp Thr Glu His Gln Glu Tyr Gly
740 745 750
Leu Ile Ile Asp Gly Ser Thr Leu Ser Leu Ile Leu Asn Ser Ser Gln
755 760 765
Asp Ser Gly Ser Asn Asn Tyr Lys Ser Ile Phe Leu Gln Ile Cys Met
770 775 780
Lys Cys Thr Ala Val Leu Cys Cys Arg Met Ala Pro Leu Gln Lys Ala
785 790 795 800
Gln Val
<210>12
<211>339
<212>PRT
<213>牛
<400>12
Ser Asp Val Phe Gly Asn Glu Phe Ser Ile Leu Arg Ser Pro Gly Ser
1 5 10 15
Val Val Phe Arg Asn Gly Asn Trp Pro Ile Pro Gly Glu Arg Ile Pro
20 25 30
Asp Val Ala Ala Leu Ser Met Gly Phe Ser Val Lys Glu Asp Leu Ser
35 40 45
Trp Pro Gly Leu Ala Val Gly Asn Leu Phe His Arg Pro Arg Ala Thr
50 55 60
Val Met Val Met Val Lys Gly Val Asp Lys Leu Ala Leu Pro Pro Gly
65 70 75 80
Ser Val Ile Ser Tyr Pro Leu Glu Asn Ala Val Pro Phe Ser Leu Asp
85 90 95
Ser Val Ala Asn Ser Ile His Ser Leu Phe Ser Glu Glu Thr Pro Val
100 105 110
Val Leu Gln Leu Ala Pro Ser Glu Glu Arg Val Tyr Met Val Gly Lys
115 120 125
Ala Asn Ser Val Phe Glu Asp Leu Ser Val Thr Leu Arg Gln Leu Arg
130 135 140
Asn Arg Leu Phe Gln Glu Asn Ser Val Leu Thr Ser Leu Pro Leu Asn
145 150 155 160
Ser Leu Ser Arg Asn Asn Glu Val Asp Leu Leu Phe Leu Ser Glu Leu
165 170 175
Gln Val Leu Arg Asp Ile Ser Ser Leu Leu Ser Arg His Lys His Leu
180 185 190
Ala Lys Asp His Ser Pro Asp Leu Tyr Ser Leu Glu Leu Ala Gly Leu
195 200 205
Asp Glu Ile Gly Lys His Tyr Gly Glu Asp Ser Glu Gln Phe Arg Asp
210 215 220
Ala Ser Lys Ile Leu Ile Asp Ala Leu Gln Lys Phe Ala Asp Asp Met
225 230 235 240
Tyr Asn Leu Tyr Gly Gly Asn Ala Val Val Glu Leu Val Thr Val Arg
245 250 255
Ser Phe Asp Thr Ser Leu Val Arg Lys Thr Arg Asn Ile Leu Glu Thr
260 265 270
Lys Gln Val Lys Asp Pro Ser Thr Thr Tyr Asn Leu Ala Tyr Lys Tyr
275 280 285
Asn Phe Glu Tyr Pro Val Val Phe Asn Leu Val Leu Trp Ile Met Ile
290 295 300
Gly Leu Ala Leu Thr Leu Ile Val Thr Cys Tyr Asn Ile Trp Asn Met
305 310 315 320
Asp Pro Gly Tyr Asp Ser Ile Ile Tyr Arg Met Thr Asn Gln Lys Ile
325 330 335
Arg Met Asp
<210>13
<211>194
<212>PRT
<213>牛
<400>13
Met Ala Ala Glu Asp Val Ala Ala Thr Gly Ala Asp Thr Ser Glu Leu
1 5 10 15
Glu Ser Gly Gly Leu Leu Gln Glu Ile Phe Thr Ser Pro Leu Asn Leu
20 25 30
Leu Leu Leu Gly Leu Cys Ile Phe Leu Leu Tyr Lys Ile Val Arg Gly
35 40 45
Asp Gln Pro Ala Ala Ser Asp Ser Asp Asp Asp Glu Pro Pro Pro Leu
50 55 60
Pro Arg Leu Lys Arg Arg Asp Phe Thr Pro Ala Glu Leu Arg Arg Phe
65 70 75 80
Asp Gly Val Gln Asp Pro Arg Ile Leu Met Ala Ile Asn Gly Lys Val
85 90 95
Phe Asp Val Thr Lys Gly Arg Lys Phe Tyr Gly Pro Glu Gly Pro Tyr
100 105 110
Gly Val Phe Ala Gly Arg Asp Ala Ser Arg Gly Leu Ala Thr Phe Cys
115 120 125
Leu Asp Lys Glu Ala Leu Lys Asp Glu Tyr Asp Asp Leu Ser Asp Leu
130 135 140
Thr Pro Ala Gln Gln Glu Thr Leu Ser Asp Trp Asp Ser Gln Phe Thr
145 150 155 160
Phe Lys Tyr His His Val Gly Lys Leu Leu Lys Asp Gly Glu Glu Pro
165 170 175
Thr Val Tyr Ser Asp Glu Glu Glu Pro Lys Asp Glu Ser Thr Arg Lys
180 185 190
Asn Asp
<210>14
<211>214
<212>PRT
<213>牛
<400>14
Tyr Thr Ser Thr Met Ser Leu Leu Ile Asn Ser Ala Asn Cys Gln Ile
1 5 10 15
Val Gly Phe Ala Val Ala Thr Ile Gly Trp Ile Leu Gly Thr Thr Ala
20 25 30
Met Gly Phe Val Glu Trp Arg Val Trp Tyr Leu Asp Asn Ala Ser Gln
35 40 45
Phe Ser Gly Leu Ala Cys Met Gly Met Trp Arg Val Cys Val Phe Arg
50 55 60
Gln Thr Asn Ile Thr Thr Ala Thr Ser Cys His Ser Tyr Ser Tyr His
65 70 75 80
Asp Thr Tyr Leu Pro Leu Asp Ile Arg Val Ser Gln His Leu Leu Leu
85 90 95
Met Ala Ser Ile Leu Gly Leu Leu Gly Lys Ala Ser Val Thr Phe Ala
100 105 110
Leu Lys Asn Val Ser Met Gly Ile Leu Glu Asn Thr Thr Thr Tyr Lys
115 120 125
Ala Phe Val Ile Ser Gly Ile Leu His Ile Ala Ala Gly Ile Cys Ile
130 135 140
Ser Val Ala Val Ile Trp Asn Tyr His Ser Val Met Thr Glu Glu Gly
145 150 155 160
Ile Val Phe Pro Pro Ser Phe Asn Ile Pro Phe Lys Pro Tyr Ala Gln
165 170 175
Lys Ile Gly Asn Thr Val Ile Val Ala Cys Leu Ala Ala Phe Ala Leu
180 185 190
Phe Leu Gly Gly Trp Phe Phe Leu Ser Tyr Lys Leu Pro Leu Asp Asn
195 200 205
Gln Val His Pro Glu Val
210
<210>15
<211>358
<212>PRT
<213>牛
<400>15
Met Ala Thr Ser Ala Asp Gly Ile Glu Thr Val Gly Glu Val Ala Gly
1 5 10 15
Thr Thr Pro Tyr Asp Tyr Glu Ala Ala Leu Pro Cys Glu Lys Ser Asn
20 25 30
Val Lys Glu Leu Ala Ala Gln Phe Leu Pro Pro Leu Tyr Ser Leu Val
35 40 45
Phe Val Thr Gly Leu Leu Gly Asn Val Val Val Val Val Ile Leu Thr
50 55 60
Lys Tyr Lys Arg Leu Arg Ile Met Thr Asn Ile Tyr Leu Leu Asn Leu
65 70 75 80
Ala Ile Ser Asp Val Leu Phe Leu Phe Thr Leu Pro Phe Trp Ile His
85 90 95
Tyr Val Arg Trp Asn Glu Trp Val Phe Gly His Arg Met Cys Lys Leu
100 105 110
Leu Ser Gly Leu Tyr Tyr Met Gly Leu Tyr Ser Glu Ile Phe Phe Ile
115 120 125
Ile Leu Leu Thr Ile Asp Arg Tyr Leu Ala Ile Val His Ala Val Phe
130 135 140
Ala Leu Arg Ala Arg Thr Val Thr Phe Gly Ile Val Thr Ser Ile Phe
145 150 155 160
Thr Trp Val Leu Ala Gly Leu Ala Ala Leu Pro Glu Phe Phe Phe His
165 170 175
Glu Thr Gln Glu Glu Ala Gly Gln Thr Phe Cys Ser Pro Leu Tyr Pro
180 185 190
Glu Asp Asn Glu Asn Ala Trp Lys Arg Phe His Ala Leu Arg Met Asn
195 200 205
Ile Leu Gly Leu Ala Leu Pro Leu Leu Val Met Ala Ile Cys Tyr Ser
210 215 220
Gly Ile Ile Lys Thr Leu Leu Arg Cys Pro Ser Lys Lys Lys Tyr Lys
225 230 235 240
Ala Ile Arg Leu Ile Phe Val Ile Met Val Val Phe Phe Ile Phe Trp
245 250 255
Thr Pro Tyr Asn Leu Val Val Leu Leu Phe Ala Phe Gln Met His Leu
260 265 270
Lys Ala Asp Cys Glu Gln Ser Arg Gln Leu Asp Leu Ala Met Leu Val
275 280 285
Thr Glu Val Ile Ala Tyr Thr His Cys Cys Val Asn Pro Val Ile Tyr
290 295 300
Ala Phe Val Gly Glu Arg Phe Arg Lys His Leu Arg His Phe Phe His
305 310 315 320
Arg Tyr Met Ala Thr Tyr Leu Gly Lys Phe Met Pro Phe Leu Pro Ser
325 330 335
Glu Lys Leu Glu Arg Thr Ser Ser Val Ser Pro Ser Thr Gly Glu Gln
340 345 350
Glu Leu Ser Ala Val Phe
355
<210>16
<211>360
<212>PRT
<213>牛
<400>16
Leu Thr Met His Thr Thr Leu Pro Glu Ser Thr Ser Glu Asn Phe Glu
1 5 10 15
Tyr Tyr Asp Leu Ala Glu Ala Cys Asp Met Gly Asp Ile Val Ala Leu
20 25 30
Gly Thr Val Phe Val Val Ile Leu Tyr Ser Leu Val Phe Ala Phe Gly
35 40 45
Leu Val Gly Asn Leu Leu Val Val Phe Ala Leu Ile Asn Ser Gln Arg
50 55 60
Ser Lys Ser Ile Thr Asp Ile Tyr Leu Leu Asn Leu Ala Leu Ser Asp
65 70 75 80
Leu Leu Phe Val Ala Thr Leu Pro Phe Trp Thr His Tyr Val Ile Asn
85 90 95
Glu Gln Gly Leu His His Ala Thr Cys Lys Leu Ile Thr Ala Phe Phe
100 105 110
Phe Ile Gly Phe Phe Gly Gly Ile Phe Phe Ile Thr Val Ile Ser Val
115 120 125
Asp Arg Phe Leu Ala Ile Val Leu Ala Ala Asn Ser Met Ser Asn Arg
130 135 140
Thr Val Gln His Gly Val Thr Thr Ser Leu Gly Val Trp Ala Ala Ala
145 150 155 160
Ile Leu Val Ala Thr Pro Gln Phe Met Phe Thr Arg Glu Lys Glu Asn
165 170 175
Glu Cys Phe Gly Asp Tyr Pro Glu Ile Leu Gln Glu Ile Trp Pro Val
180 185 190
Ile Leu Asn Thr Glu Ile Asn Phe Leu Gly Phe Leu Leu Pro Leu Leu
195 200 205
Ile Met Ser Tyr Cys Tyr Phe Arg Ile Met Gln Thr Leu Phe Ser Cys
210 215 220
Lys Asn His Lys Lys Ala Lys Ala Ile Arg Leu Ile Phe Leu Val Val
225 230 235 240
Val Val Phe Phe Leu Phe Trp Thr Pro Tyr Asn Val Met Ile Phe Leu
245 250 255
Gln Thr Leu Asn Leu Tyr Asp Phe Phe Pro Lys Cys Asp Val Lys Arg
260 265 270
Asp Leu Lys Leu Ala Ile Ser Val Thr Glu Thr Ile Ala Phe Ser His
275 280 285
Cys Cys Leu Asn Pro Leu Ile Tyr Ala Phe Ala Gly Glu Lys Phe Arg
290 295 300
Arg Tyr Leu Tyr Arg Leu Tyr Arg Lys Cys Leu Ala Val Leu Cys Cys
305 310 315 320
His Pro Asp His Leu Ser Phe Ser Ser Ser Leu Ser Glu Ser Gln Arg
325 330 335
Ser Arg Arg Glu Ser Val Leu Ser Ser Asn Phe Thr His Tyr Thr Ser
340 345 350
Asp Gly Asp Ala Ser Ile Leu Leu
355 360
<210>17
<211>153
<212>PRT
<213>牛
<400>17
Met Trp Ser Leu Lys Ser Phe Leu Cys Leu Ser Ile Val Val Ser Cys
1 5 10 15
Val Tyr Ala Leu Met Phe Thr Ser Leu Thr Glu Lys Val Lys Glu Ile
20 25 30
Gln Trp Lys Val Leu Cys Arg Gly His Phe Leu Ile Gln Gln Asn Leu
35 40 45
Gln Glu Gln Ala Gln Asp Trp Leu Glu Ile Thr Leu Leu Trp Leu Phe
50 55 60
Phe Ile Val Leu Met Tyr Val Thr Val Lys Leu Ala Gly Glu Asn Gly
65 70 75 80
Glu Ser Arg Val Gln Thr Ser His Ala Leu Gln Gly Arg Ser Phe Gly
85 90 95
Phe Leu Gly Asn Lys Lys Val Lys Thr Ser Ser Lys Glu Val Tyr Met
100 105 110
Phe His Thr Leu Thr Leu Leu Glu Met Asp Leu Val Lys Phe Val Cys
115 120 125
Arg Val Gln Asn Leu Lys Leu Ala Thr Ser Thr Ser Gly Asn Ile Asn
130 135 140
Pro Leu Asn Val Lys Val Pro Ala Asp
145 150
<210>18
<211>346
<212>PRT
<213>牛
<400>18
Met Ala Arg Pro Gly Gln Arg Trp Leu Gly Lys Trp Leu Val Ala Met
1 5 10 15
Val Val Leu Ala Leu Cys Arg Leu Ala Thr Pro Leu Ala Lys Asn Leu
20 25 30
Glu Pro Val Ser Trp Ser Ser Leu Asn Pro Lys Phe Leu Ser Gly Lys
35 40 45
Gly Leu Val Ile Tyr Pro Lys Ile Gly Asp Lys Leu Asp Ile Ile Cys
50 55 60
Pro Arg Ala Glu Ala Gly Arg Pro Tyr Glu Tyr Tyr Lys Leu Tyr Leu
65 70 75 80
Val Arg Pro Glu Gln Ala Ala Ala Cys Ser Thr Val Leu Asp Pro Asn
85 90 95
Val Leu Val Thr Cys Asn Arg Pro Glu Gln Glu Ile Arg Phe Thr Ile
100 105 110
Lys Phe Gln Glu Phe Ser Pro Asn Tyr Met Gly Leu Glu Phe Lys Lys
115 120 125
His His Asp Tyr Tyr Ile Thr Ser Thr Ser Asn Gly Ser Leu Glu Gly
130 135 140
Leu Glu Asn Arg Glu Gly Gly Val Cys Arg Thr Arg Thr Met Lys Ile
145 150 155 160
Val Met Lys Val Gly Gln Asp Pro Asn Ala Val Thr Pro Glu Gln Leu
165 170 175
Thr Thr Ser Arg Pro Ser Lys Glu Ala Asp Asn Thr Ile Lys Met Ala
180 185 190
Thr Gln Ala Pro Gly Gly Arg Ser Ser Met Gly Asp Ser Asp Gly Lys
195 200 205
His Glu Thr Val Asn Gln Asp Glu Lys Ser Gly Ser Gly Gly Asn Gly
210 215 220
Gly Ser Ser Gly Asp Pro Asp Ser Phe Phe Asn Ser Lys Val Ala Leu
225 230 235 240
Phe Ala Ala Val Gly Ala Gly Cys Val Ile Phe Leu Leu Ile Ile Ile
245 250 255
Phe Leu Thr Ile Leu Leu Leu Lys Leu Arg Lys Arg His Arg Lys His
260 265 270
Thr Gln Gln Arg Ala Pro Ala Leu Ser Leu Ser Thr Leu Ala Ser Pro
275 280 285
Lys Gly Gly Ser Gly Thr Ala Gly Thr Glu Pro Ser Asp Ile Ile Ile
290 295 300
Pro Leu Arg Thr Thr Glu Asn Asn Tyr Cys Pro His Tyr Glu Lys Val
305 310 315 320
Ser Gly Asp Tyr Gly His Pro Val Tyr Ile Val Gln Glu Met Pro Pro
325 330 335
Gln Ser Pro Ala Asn Ile Tyr Tyr Lys Val
340 345
<210>19
<211>225
<212>PRT
<213>牛
<400>19
Met Ser Ile Leu Leu Pro Asn Met Ala Glu Phe Asp Thr Ile Ser Glu
1 5 10 15
Leu Glu Glu Glu Glu Glu Glu Glu Ala Ala Thr Ser Ser Ser Ser Ser
20 25 30
Pro Ser Ser Ser Ser Ser Val Ser Gly Pro Asp Asp Asp Glu Glu Asp
35 40 45
Glu Glu Glu Glu Glu Glu Glu Asn Glu Glu Glu Glu Glu Glu Glu Glu
50 55 60
Glu Gln Val Glu Glu Thr Pro Pro Pro Pro Arg Val Val Ser Glu Glu
65 70 75 80
His Leu Arg Arg Tyr Ala Pro Asp Pro Val Leu Val Arg Gly Ala Gly
85 90 95
His Ile Thr Val Phe Gly Leu Ser Asn Lys Phe Asp Thr Glu Phe Pro
100 105 110
Ser Val Leu Thr Gly Lys Val Ala Pro Glu Glu Phe Lys Thr Ser Ile
115 120 125
Gly Arg Val Asn Ala Cys Leu Lys Lys Ala Leu Pro Val Asn Val Lys
130 135 140
Trp Leu Leu Cys Gly Cys Leu Cys Cys Cys Cys Thr Leu Gly Cys Ser
145 150 155 160
Leu Trp Pro Val Ile Cys Leu Asn Lys Arg Thr Arg Arg Ser Ile Gln
165 170 175
Lys Leu Leu Glu Trp Glu Asn Asn Arg Leu Tyr His Lys Leu Ala Leu
180 185 190
His Trp Lys Leu Thr Lys Arg Lys Cys Glu Thr Ser Asn Met Met Glu
195 200 205
Tyr Val Ile Leu Ile Glu Phe Leu Pro Lys Tyr Pro Ile Phe Arg Pro
210 215 220
Asp
225
<210>20
<211>173
<212>PRT
<213>牛
<400>20
Gln Leu Thr Met Arg Ser Val Ile Trp Leu Phe Phe Trp Pro Thr Leu
1 5 10 15
Ile Ser Phe Val Phe Ala Tyr Val Phe Tyr Val Leu Arg Asp Glu Ala
20 25 30
Glu Glu Leu Pro Trp Met Val Pro Ser Gly Arg His Phe Arg Val Arg
35 40 45
Gln Asn Gln Pro Glu Tyr Ala Pro Gly Trp Phe Gly Ser Lys Trp His
50 55 60
Trp Leu Leu Ile Phe Leu Met Phe Leu Val Ile Leu Lys Phe Pro Gly
65 70 75 80
Gly Asp Asp Glu Ser Asn Ala Gly Thr Pro Pro Gly Arg Gln Gly Cys
85 90 95
Ser Ser Gly Ser Pro Gly Arg Lys Lys Ile Arg Asp Ser Pro Tyr Lys
100 105 110
Glu Ser Met Cys Gly Ala Leu Thr Gln Ser Glu Thr Ser Leu Met Asn
115 120 125
Leu Met Ser Arg Val Lys Asn Met Lys Leu Thr Ala Ala Thr Gly Asp
130 135 140
Gln Cys Gln Cys Pro Asn Ile Glu Val Pro Gly Asp Ala Arg Asn Asn
145 150 155 160
Val Thr Ile Leu Glu Val Trp Asp Thr Gly Asp Pro Asp
165 170
<210>21
<211>92
<212>PRT
<213>牛
<400>21
Thr Met Leu Lys Ser Leu Ser Cys Ile Leu Phe Leu Lys Ala Cys Val
1 5 10 15
Pro Val Glu Gly Gln Val Leu Thr Pro Cys Lys Gln Gly Gln Asp Leu
20 25 30
Asn Lys Asp Glu Cys Leu Lys Tyr Lys Cys Cys Tyr Ser Ser Ile Glu
35 40 45
Thr Ala Thr Val Ser Cys Phe Ala Pro Leu Arg Asp Ser Lys Leu Ile
50 55 60
Leu Leu Gln Met Phe Gly Phe Gly Ala Met Ser Met Val Phe Leu Gly
65 70 75 80
Cys Leu Pro Met Tyr Cys Cys Ser Phe Cys Trp Lys
85 90
<210>22
<211>3663
<212>DNA
<213>牛
<400>22
atgggcgacg tggccaacag ttccatcgag ttccacccca aaccccagca gcagcgggag 60
gccccacatg caggtggctt cgggtgcacg ctggccgagc tgcgctccct catggagctc 120
cggggggccg aggcactgca gaaagtccag gaggcctatg gggacgtgag cgggctttgc 180
aggaggctga agacctcacc caccgagggc ctggctgaca atgccaacga cctggagaag 240
cgcaggcaga tctacgggca gaacttcatc ccccccaagc agcccaagac ctttctacag 300
ctggtgtggg aggccctgca ggatgtgacc ctcatcatcc tggaggtggc tgccatcgtg 360
tccctgggcc tctcattcta tgcaccgccc ggggaggaga gcgaagcctg tgggaatgtg 420
tcggctgggg ccgaagacga aggggaagcc gaggcgggct ggatcgaggg ggccgccatc 480
ctgctgtctg tcatctgcgt ggtcctggtc acggccttca acgactggag caaagagaag 540
cagttccgag gcctgcagag tcgcatagag caggagcaga agttcaccgt catccggaat 600
gggcagctcc tccaggtgcc cgtggccacg ctcgtggtgg gagacatcgc ccaggtcaag 660
tatggagacc tgctgcctgc cgatggcgtg ctcatccagg gcaacgacct caagatcgat 720
gagagctccc tgacgggcga gtcggaccat gtgcgcaagt cgacagacaa ggaccccatg 780
ctgctgtcag gcactcatgt catggaaggt tctggaagaa tggtggtgac ggctgtgggt 840
gtgaattccc agacgggcat catctttacc ttgcttggag ctggtggaga ggaggaagag 900
aagaaggata agaaaggcaa gcagcaggat ggggcgatgg agagtagcca gaccaaagca 960
aagaaacagg atggggctgt tgccatggaa atgcagcccc taaagagcgc agagggcggg 1020
gagatggagg agcgggagaa gaagaaagcc aatgtgccca agaaggagaa atcagtcctt 1080
cagggaaagc tcaccaaact ggccgtgcag attgggaaag cagggctggt gatgtccgcc 1140
atcactgtta tcatcctggt cctctacttt gtgatcgaga ccttcgtcat agacggccgg 1200
atgtggctgg cggagtgcac gcctgtctac gtgcagtact tcgtcaagtt cttcatcatc 1260
ggtgtcactg tgctggttgt ggctgtccca gagggcctgc ctctcgctgt caccatctcc 1320
ttagcttact ctgtcaagaa aatgatgagg gacaacaacc tggtccgcca cctggatgcc 1380
tgcgagacca tgggcaatgc cacagccatc tgttctgaca agacgggcac actcaccacc 1440
aaccgcatga ccgtggtgca gtcctacctt ggggacaccc actacaaaga ggttccagcc 1500
cccagtgccc tgacccccaa gatcctcgac atcctggtcc atgccatctc catcaacagt 1560
gcctacacca ccaaaatact acctccagag aaggaaggcg ccctcccacg ccaagtgggc 1620
aacaagacgg agtgtgctct gcttggcttt gtcctggacc tcaagcggga cttccagccg 1680
gtgcgggagc agattcccga agataagctt tataaagtgt acaccttcaa ctcggtccgc 1740
aagtccatga gcacggtcat ccgcacgcct gatggtggct tccgcctctt cagcaagggc 1800
gcctcagaga tcctgctgaa aaagtgcacc aacatcttga acagcaatgg ggaactccgc 1860
agctttcgcc ctcgggaccg ggatgacatg gtgaagaaga tcatcgagcc gatggcctgc 1920
gatgggctcc gcaccatttg catcgcctac cgggacttca ccgccgccca ggagcccgac 1980
tgggacaatg agaacgaggt ggtgggcgac ctcacctgca tagccgtcgt gggcatcgag 2040
gaccctgtgc ggcccgaggt ccctgaagct atccgcaaat gtcagagggc tggcatcaca 2100
gtccgcatgg tgacggggga caacatcaac acagctcgcg ccattgcagc caagtgtggc 2160
atcatccagc ccggggagga cttcctgtgc ctggagggga aagagttcaa ccggcggatc 2220
cgaaacgaga aaggcgagat agaacaggag cgtctggaca aggtgtggcc taagctgagg 2280
gtcctggcgc gatcatctcc caccgacaaa catactctgg ttaaagggat catcgacagc 2340
aacacgggtg agcaacggca ggtggtggcc gtgacaggag atggcaccaa tgacgggcca 2400
gccctcaaga aggcagatgt gggcttcgcc atgggcatcg cagggacaga tgtggccaag 2460
gaggcctcag acatcatcct gacggacgac aacttcacca gcatcgtcaa ggctgtcatg 2520
tggggccgca atgtctacga cagcatctcc aagttcctgc agttccagct gacggtcaac 2580
gtggtggccg tgattgtggc cttcacgggc gcctgcatca ctcaggactc tcctctcaaa 2640
gccgtgcaga tgttgtgggt gaatttgatc atggacacat tcgcctctct ggctctggca 2700
acagagccac ccactgagtc gctgctgctg cggaagccat acggccggga caagcccctg 2760
atctcacgga ccatgatgaa gaacatcctg ggccatgccg tctaccagct caccatcatc 2820
ttcaccctgc tctttgtcgg ggagctcttc tttgacattg acagtggacg gaacgctccc 2880
ctgcactcgc caccctctga gcactacacc atcatcttca acaccttcgt catgatgcag 2940
ctcttcaacg agatcaatgc ccgcaagatc catggcgagc gcaatgtgtt ccatggcatc 3000
ttcagcaacc ccatcttctg caccatcgtg ctaggaacct ttgctatcca gattgtcatc 3060
gtccagttcg gtggaaagcc cttcagctgt tccccactgt ccacggagca gtggctctgg 3120
tgcctgtttg tcggtattgg ggaactggtc tggggacagg tcatcgcaac catccccacc 3180
agccagctta agtgcctgaa ggaagcagga catgggcccg ggaaggatga gatgactgac 3240
gaggagctgg ctgaaggaga agaagagatt gaccacgccg agcgggagct ccgcagaggc 3300
cagatcctct ggttccgggg cctcaaccgg atccagacac agattcgggt ggtgaaagcg 3360
ttccgtagct ccctctacga aggcctggag aaaccagaat ccaagacctc catccataac 3420
ttcatggcga cgcctgagtt tctgatcaat gactacaccc acaacatccc gctgattgac 3480
gacacggacg tggatgagaa cgaggaacgc ctgcgagccc caccgccgcc ctcccccaac 3540
cagaataaca atgccataga cagcggcgtc tacctgacca cgcacggcac caagtcagct 3600
acctcttcac tgttttcttc cagacccggg agcccgctcc acagcgtgga gacgtccctc 3660
taa 3663
<210>23
<211>1200
<212>DNA
<213>牛
<400>23
atgtctcaaa ggcagcctca gtcacctaat cagactttaa tttcaaccac aaatgacaca 60
gaattatcga gctccgtcgt ccctaatgat tccacaaata aaagaaggac cggagacaac 120
tctccaggaa tagaagcatt gtgtgccatc tatatcactt atgccgtgat catttcagtg 180
ggcatccttg gaaatgctat tctcatcaaa gtctttttca agaccaaatc catgcaaaca 240
gttcccaaca ttttcatcac cagcctggct tttggagatc ttttacttct gctaacttgt 300
gtgccagtcg atgcaaccca ctacctggca gagggatggc tgttcggaag aattggatgt 360
aaggtgctct ctttcatccg gctcacttct gtcggtgtat cagtgttcac gttaacaatt 420
ctcagtgctg acagatacaa ggcagttgtg aagcccttgg agcgtcagcc cccaaatgcc 480
atcctgaaga cctgtgccaa agctggctgc atctggatca tgtctatgat cattgctcta 540
ccggaggcta tattttcaaa tgtatatact tttcaagatc ctgacaaaaa cgtaacattt 600
aaagtgtgtg cctcttaccc tgtttctgag aggctcctgc aagagataca ttctctgctg 660
tgcttcttag tattctacat tattccactt tcgattatct ctgtctatta ctctctgatt 720
gctagaactc tttacaaaag caccttgaac atacctactg aggaacaaag ccatgcccgc 780
aagcagattg aatcccggaa gcgaattgcc agaacagttc tggtgctggt ggctctcttt 840
gctctctgct ggttgccgaa tcaccttctg tatctctacc gctcattcac ttctcaaaac 900
tatacggact cctctaccgt tcacttaatt gtcaccatca tctctcggat tctggctttc 960
agcaattctt gtgtaaaccc ctttgctctt tactggctga gcaatacctt ccagcagcat 1020
tttaaagctc agttattctg ttgcaaggca ggggtgcctg acgcttctgc tgctaatacc 1080
cctcttgaca acctagcagt gatgggaagg gtcccgggtg ctgcaagcac tcagatgtcc 1140
gaaattagtg tgtccctatt cactggctgc agtgtgaaga aggaagatga cagagtctag 1200
<210>24
<211>453
<212>DNA
<213>牛
<400>24
ccacagatcg gcggcagggg ccggaacgga gacgagagct gctcgcgcgc gctcaggggg 60
cggccgcagc accgccctcc ccggaggaca atgctgcgag gcaagtcccg gctcaacgtg 120
gagtggctgg gctactcgcc cggcctgctc ctagagcgca ggccgctcct ggcagggcgt 180
acgccccgca gccctggccg aaatgaaagt tcattagcat ccactctgaa gacgctcctg 240
ttcttcacag ctttaatgat cactgtacct attgggttat atttcacaac taaatcttac 300
gtttttgaag gcgcctttgg gatgtccaat agggacagct atttttatgc tgctattgtt 360
gcagtggtcg ccgtccacgt ggtgctggcc ctctttgttt atgtggcctg gaatgaaggc 420
tcacggcagt ggcgtgaagg caaacaggat taa 453
<210>25
<211>1541
<212>DNA
<213>牛
<400>25
aggggccttt tccaggactt caacccgagt aaattcctca tctatgcctg tctactgctg 60
ttctctgtgt tgctggccct tcgtctagat ggcatcattc agtggagtta ctgggctgtt 120
tttgctccaa tatggctgtg gaagttaatg gtcattgttg gagcctcagt tggaactgga 180
gtctgggcac ggaatcccca atatcgagca gaaggggaaa catgtgtgga gttcaaggcc 240
atgctaattg cagtgggcat ccacttgctg ttgctgatgt ttgaagtgct ggtgtgcgac 300
aggattgaga gaggcagcca cttctggctc ctggtcttca tgccactctt cttcgtttcc 360
cccgtgtctg tggcagcttg tgtttggggc tttcgccatg acaggtcact ggagttagaa 420
atcctgtgtt ctgtcaacat tctccagttt atattcattg ccttaagact ggacaagatc 480
attcactggc cctggcttgt cgtgtgtgtc cccttgtgga ttctcatgtc gtttctgtgt 540
ctggtagtcc tctactacat cgtgtggtcc gtcctgttcc tgcgttccat ggatgtgatc 600
gcagagcaga ggaggacaca catcaccatg gcgctaagct ggatgaccat cgttgtgcca 660
ctccttactt ttgagatcct gctggttcat aagctggacg gccacaatgc attctcctgt 720
atccccatat ttgtccccct ttggctttcc ttgatcactc tgatggcaac caccttcgga 780
cagaaaggcg gaaaccactg gtggtttggg attcgcaagg atttctgtca gtttctgctt 840
gaaatctgcc cgtttttgag agaatatgga aacatctcct acgacctcca ccatgaaggt 900
agcgaggaaa ctgaagaaac gccagttcca gaacctccta agatcgctcc tatgtttcga 960
aagaagaccc gggtggttat cacccagagc cctgggaagt acgtcctccc acctcccaaa 1020
ttaaatatcg aaatgccaga ttagaccgtg ttcccagggc agatcaagag tgcacctggc 1080
ccgccctctt ttccaccttc ttctgcctcc attcaccccc tccctcccac cctgaactgg 1140
agctggagct gggtctccag ggacttccat ctcatgcctt gtttgcactc aatgcctacc 1200
cagtgactca ccgccacggg acatgcggct ggcaggtgcc tggaacatgc agcgtggtgt 1260
agggtgcaca tcagcggatt tggacctgat ggagggagca tatggagaca gaggaaacaa 1320
ctcccagtgg gcaggtgcct tcagagctgg cttgggccca agaaggaatg gccacccagc 1380
tggttttcta agtgtgaaaa ttcccatcaa aagtgttatt gaaaaatgta ttattgaacc 1440
aagccagcct ggccacttag ctcagaaact cctgttgtgg tgtggtcagg ggccctgact 1500
aagcctcagg cctcacatgc acccacacca ctgtcactgg c 1541
<210>26
<211>2339
<212>DNA
<213>牛
<400>26
agtttgagac tcagcctagc tcaggcaagc tactggacct tgactgcgct cagcgaacct 60
cagcacaatg gggttaacat tttggaaggt gtttctgatt ctcaactgcc ttgcaggtca 120
agttaatgga gtgcaagtga ccatcccaga cagttttgtg aatgtgactg ttggatctga 180
tgtcactctc atctgcacct acgccaccac tgtggcctca ctgaacaaac tctccattca 240
gtggacattc ttccataagg aggcgtcaca accagtttct atttactatt ctgaaggtgg 300
acaagctaca gccataggaa aatttaaaga tcgcattgta ggatccaaca cttcaggtaa 360
cgcatccatc accatctcgc atatgcagcc agaagacagt ggcatctaca tctgtgatgt 420
taacaacccc cctgactttt tcggcaaaaa tcaaggcacc atcagcgtca gcgtgttagt 480
caaaccttct aagcccttct gcagcatcca aggaatagca gaaactggcc atcctatatc 540
tcttacttgc ctttcggtgc ttggaacacc ttcccctgtg tactactggt ataaacttga 600
aggaagaaac attgtcccag tgaaagaaaa cttcaaccca gccaccggga ttttgtttat 660
tggaaacctg accacttttg aacaaggtta ttaccagtgc accgctatta acatacttgg 720
caatagttcc tgtgaaattg acctaactac tccatatcca ggaattggaa tcattgttgg 780
ggcctttgtg gggaccctga taggtgtcat catcatcatc tctgtggtgt ggttcgtgag 840
gcgtaaggta aaggcaaagg ggaaggaaag gaagaggaat tctaaaacca ccacagaact 900
cgaaccaatg acaaagataa accaaagaac ggagggtgag acaatgccac gtgaagatgc 960
catccaactc gaagccaccc ttccgtcttc cacccatgag actgagccta atgctaccct 1020
ggggccagat catgagccta tccccgagcc tgagcctgcc ttgcagccta ctgtggagcc 1080
accctctggg cctgagcttg tccccatgtc tgagcttgag atccagctgg agccagagcc 1140
tgcgccccag caggagcccg agcccttgat tgtagatgag ccattttgtg atgaggagaa 1200
ggtgattaag ccataggcca gcggcctgag tccaatgttc atcaccaagg aacccattag 1260
tggcatgtgg aattgagttg acctaactaa tttcccacca cctgcctcca ttctggccaa 1320
ccctcttcta acatggagct cttaccatca atccagaata actactaaat aaacgcaagg 1380
gttcctgcat taccagtcta gagtacttaa tttcactaac ctgtaaacac aattaatgac 1440
aagtgattct gaactcagtt gaaggtgttt tgccacaaca cctgtgtctt atttcagaaa 1500
tcttatttct ctatttttag ctactctttg gcattccaca tgcacacatg acaaggtgcc 1560
attaactgga ttgaatatta tttcttggat ttgctgttat cagagcttcc ctattcattt 1620
tcacattgat cagtacgaat tcaccagcat tatctcatag actgggaaaa aaaatcctta 1680
aaattccaga gaagaaaggg tacctattaa ttagtacata ccatttaaaa ctaggtctta 1740
aaattaatgc ttcatttatc gtattagatt tcccagagaa ccactctgct atccaatatc 1800
tgagcacagc aaaattttaa attaaatcaa ctttttaaat gcaaaataat gtacaggcaa 1860
acaattccaa atataacttt ctttcaatga atacaaaatg ttgatatcac aggtaatgta 1920
caatttagct ttgaatgagg tattatgttg tctcactgat gctctctcta ctttggaagg 1980
gccaaactaa atgaacacct aagatctatc ttagataatc agaacacatt aattgtttta 2040
ctgttgggat atttcacatt aacaaagaga tatcattctt gtgtaaatgc taactattaa 2100
ctaaaatgca ttcatatcac ctcttcacct gctaaaaagc ttttctattg attatattta 2160
tccacactcc actttgaata aatttacacg tagacttttt catttgtgta atcagatttt 2220
aaatctttaa aataatactc aataaaaatc ttactttaat gagcctaagg taaatctttt 2280
atgaataatt ttattggttt taactttatg tataataaac tgcacctatt tcaagtgtt 2339
<210>27
<211>1648
<212>DNA
<213>牛
<400>27
aggtgtgttc cttattccct acatcctgat cgccctgatt ggaggaatcc ccatcttctt 60
cttggagatc tcgctgggcc agttcatgaa ggccggcagc atcaacgtct ggaatatctg 120
ccccctgttc aaaggcctgg gctacgcctc catggtgatc gtcttctact gcaacaccta 180
ttacatcatg gtgctggcct ggggcttcta ttatctggtg aagtccttca ccaccacgct 240
gccctgggcc acgtgtggcc acacgtggaa cactcccgat tgcgtggaga tcttccgcca 300
cgaagactgt gccaatgcca ccatggccaa cctcacatgt gaccagcttg ctgaccgccg 360
gtccccggtc atcgagttct gggagaacaa agtcttgcgg ctctctgaag ggctggaggt 420
gccaggggcc ctcaactggg aggtgaccct gtgtctgctg acctgctggg tgctggtcta 480
cttctgtgtc tggaaggggg tcaagtcaac aggcaagatc gtgtatttca ccgctacatt 540
cccctatgtg gtcctcgttg tgctgctggt gcgcggagtg ctgctacctg gcgctttgga 600
tggcatcatc tactatctca agcctgactg gtcaaagctg gcatcccctc aggtatggat 660
cgacgcaggg acacagatct tcttctctta cgccatcggc ttgggggccc tcaccgccct 720
gggcagctac aatcgcttca acaacaactg ctacaaggat gccatcatac tcgccctcat 780
caacagcggg accagcttct ttgcaggctt cgtggtgttc tccatcctgg gcttcatggc 840
cacagaacag ggcgtgcaca tctccaaggt agcagaatca gggcctggcc tggctttcat 900
cgcctatccg cgggccgtca cgctgatgcc cgtggcccca ctctgggcag ctctgttctt 960
cttcatgctg ttgctgcttg gtctggacag ccagtttgta ggtgtcgaag gcttcatcac 1020
tggcttgctg gacctcctcc cagcctccta ctacttccga ttccaaaggg agatctccgt 1080
ggccctctgt tgcaccatct gctttgtcat cgacctctcc atggtgactg atggcgggat 1140
gtatgtcttc cagctgtttg actactactc agccagtggc accacactgc tctggcaggc 1200
cttctgggag tgtgtggtgg tcgcctgggt gtacggagct gatcgcttca tggatgatgt 1260
ggcctgcatg atcgggtacc gaccttgccc ctggatgaaa tggtgctggt ctttcttcac 1320
cccactggtg tgcatgggca tcttcatctt caatgtggtc taccatgagc cgctggtcta 1380
caacaatacc tacgtgtacc cgtggtgggg cgaggccgtg ggctgggcct ttgcgctctc 1440
ctccatgcta tgtgtgcccc tccacctcct gggctgcctc ctcagggcca aggggaccat 1500
ggctgagcgc tggcagcacc tgacgcagcc catctggggc ctccaccacc tggaatacag 1560
agctcaagac tcggatgtca ggggcctgac caccctgacc ccagtgtctg agagcagcaa 1620
ggtggtggtg gtggaaagcg tcatgtga 1648
<210>28
<211>4515
<212>DNA
<213>牛
<400>28
gaagaaatca aaatggatct gagtgtgagt gtgaattctg tcaccatctc tgttgaggga 60
atgacatgta gttcctgtgt ttggaccatt gaacagcaga ttggaaaact gaatggtgta 120
catcatatta aagtttcact ggaagaaaaa aatgcaactg ttatttatga cccaaaacta 180
caaactccaa agaccctgca ggaagctatt gatgacatgg gctttgatgc tattctccac 240
aatcctaagc ctctccctgt tttaactgaa actgtgtttc tgactgttac tgcttcactg 300
gttccgccat gggaccatat ccaaagcaca ttgctcaaga ccaagggtgt gacagatatt 360
aaaatttccc ctcagcagag aactgcagtg gtgacaataa tcccttctat agtgaatgcc 420
aatcagatag tagagctggt tcctgatctc agtttagata ctggaactct ggaaaaaaag 480
tcaggaactt gcgaagatta tagtatggct caaccaggtg aagtcatgct gaagatgaag 540
gtggaaggga tgacctgcca ttcatgtact agcaccattg aaggaaaaat tgggaaactg 600
caaggtgttc agcgaattaa agtttccttg gacaatcaag aagctactgt tgtttatcaa 660
ccccatctta tcacagcaga ggaaataaaa aagcagattg aagttgtggg ctttacagca 720
ttcatcaaaa aacagcccaa gtacctcaaa ttgggagcta ttgacataga acgtctaaag 780
aacacaccag tcaaatcctc agaaggatca cagcaaaaga gtccatcata caccagtaat 840
tcaacagtca ttttcaccat agatggcatg cattgtaaat catgtgtgtc aaatattgaa 900
agtgctttat ctacactcca acatataagc agtgtagtag tttctttaga gaataaatct 960
gccatagtaa agtacaatgc aagtttagtc actccagaaa cactgagaaa agcaatagag 1020
gccatatcac aagggcaata tagagttagt agtgcaagtg aaattgagag tacctcaaac 1080
tctccctcca gctcatctct tcaaaagagt cctttgaaca tagttagcca gcctctaact 1140
caagaaactg tgataaacat tgatggcatg acttgtaatt cgtgtgtgca gtctattgaa 1200
ggtgtcatat caaaaaaggc aggtgtaaaa tccatacaag tatcacttgc aaatggcaaa 1260
gggactgttg agtatgatcc tttactaacc tctccagaaa ccttgagaga agcaatagaa 1320
aacatgggat ttgatgcttc cttgtcagat acaaatgagc cattggtagt aatagctcag 1380
ccctcatcag aaatgccact tttgacctca actaatgaat ttcacaccaa aatgatgaca 1440
ccaattcatg acaaggagga gccaaagact tcatccaagt gttatataca ggtcactggt 1500
atgacttgtg cttcctgtgt agcaaacatt gaacggaatt taagacgaga agaaggaata 1560
tattccatac ttgtggctct gatggctggc aaggcagaag taaggtataa ccctgctctc 1620
atacaacccc cagtgatagc cgagttaatc cgagagcttg gatttggatc cactgtgata 1680
gaaaatgctg atgaaggaga tggtgttttg gaacttgttg tgagaggaat gacatgtgcc 1740
tcctgtgtcc ataaaataga gtctaccctc acaaaacaca gagggatctt ctactgctct 1800
gtggccctgg caaccaacaa agcacatatt aaatatgatc cagaaattat tggtcccaga 1860
gatattattc atacaattga aagcttgggt tttgaagctt ctttggtcaa gaaggaccgg 1920
tcagcaagcc acctagacca taaacgggaa ataagacagt ggcgacgggc ctttcttgtg 1980
agcctatttt tctgtatacc tgtaatggga ctgatgatat atatgatggt tatggaccac 2040
catcttgcaa gtcttcaaca taatcagaac atgagccaag aagaaatgat caacattcat 2100
tcttctatgt tcctggagcg ccagatcctg ccaggattgt ccattatgaa tttgctatct 2160
tttttattgt gtgttcctgt acagtttttt ggaggctggc acttctatat tcaggcctac 2220
aaagcactga agcataaaac tgcaaatatg gatgtattga ttgtgctggc aacaaccatt 2280
gcatttgctt actctttggt tattcttctg gttgcaatgt atgagagagc caaagtgaac 2340
cctgttactt tctttgacac acctcctatg ctatttgtgt ttattgcact aggccggtgg 2400
ctggaacatg tagcaaaggg caaaacatca gaggctcttg ccaaactaat ttcactacaa 2460
gctacagaag caactattgt aactcttgac tctgataata tcctcttgag tgaagagcaa 2520
gtggatgtgg aacttgtaca acgtggagac attattaaag tggttccagg aggcaaattt 2580
ccagtggatg ggcgtgttat tgaaggacat tctatggtag atgagtccct catcacagga 2640
gaggcaatgc ctgtggccaa gaaatctgga agcacagtga ttgctggttc cattaaccag 2700
aatgggtcac tccttatccg tgcaacccat gttggagcag acacaaccct ttctcaaatt 2760
gtcaaacttg tagaggaggc acaaacatca aaggctccta tccagcagtt tgcagacaaa 2820
ctcagtggct actttgttcc ttttattgtt attgtttcca ttgctaccct tttggtttgg 2880
attataattg gatttctgaa ttttgaaatc gtggaaacct actttcccgg ctacaacaga 2940
agtatctccc gaacagaaac aataatacgc tttgctttcc aagcctctat cacagttcta 3000
tgcattgcat gcccctgttc cctgggactg gccactccaa ctgctgtgat ggtgggtaca 3060
ggagtaggtg ctcaaaatgg catactaatc aaaggtggtg agccattgga gatggctcat 3120
aaggtaaagg tagtggtatt tgataaaact ggaaccatta cccatggaac cccagtagtg 3180
aatcaagtaa aggttctagt ggaaagtaat agaatatcac gcaataagat cctggctatt 3240
gtgggaactg ctgaaagtaa cagtgaacac cctctgggag cagccataac gaaatactgc 3300
aagcaggagc tggatactga aaccttgggt acctgcatag atttccaggt tgtgccaggc 3360
tgtggcatta actgtaaagt caccaatatc gaagccttgc tacacaagaa taactggaag 3420
atagaggaaa ataatattaa aaatgcatcc ctggttcaaa tagatgagag taatgaacag 3480
tcatcaactt cgtcttccat gattattgat gctcagttct caaatgctct taatgctcag 3540
cagtacaaag ttctcattgg caaccgggag tggatgatta gaaatggtct tgccattaat 3600
aacagtgtaa atgattccat gactgaacat gagagaagag gtcggactgc tgtactggta 3660
gcagttgatg atgagctgtg cggtttgata gctattgctg atacagtgaa gcctgaagca 3720
gaactggctg tccatattct gaaatctatg ggcttagaag tagttctgat gactggagac 3780
aacagtaaaa cagctagatc tattgcttct caggttggca ttactaaagt gtttgctgaa 3840
gttctacctt cccacaaggt tgctaaggtg aagcaacttc aagaggaggg gaaacgggta 3900
gcaatggtag gagatggaat caatgactcc ccagctctgg cgatggctaa tgttggaatt 3960
gctattggca caggcacaga tgtagccatt gaagcagctg atgtggtttt aataaggaat 4020
gatcttctgg atgtagtggc aagtattgat ttatcaagga agacagtcaa gaggattcgg 4080
ataaattttg tctttgctct aatttataat ctgattggaa ttcctatagc tgctggagtt 4140
tttatgccca ttggtttggt tttgcaaccc tggatgggat ctgctgcaat ggctgcttca 4200
tctgtttcag tagtactttc ttcactcttc cttaaacttt acaggaaacc aacttatgag 4260
aattatgaac tacatgctcg aaaccaaatg ggacagaaaa gtccttcaga aataagtgtt 4320
catgttggaa tagatgatac ctcaagaaat tctcctaaac tgggtttgct ggaccgaatt 4380
gttaattaca gcagagcctc cataaattca ctactgtctg ataaacgatc actaaacagc 4440
gttggtacca gtgaacctga caagcactca ctcctggtcg gagactgcag ggaagatgac 4500
gacagtgcgt tgtaa 4515
<210>29
<211>1338
<212>DNA
<213>牛
<400>29
atgaaattcc cgggctcggt gctggcgtcc gtgttcctgt tcgtggccga gacgtcggcg 60
gcgttgtaca atatggtgat tcacaatttt aaaggtaatg ccccatttat agttattaca 120
aaattattta tgctgacacc aacatgcatg gtttcaggca cactcattaa gctggtaaac 180
catgaaccat ctagggggag gggtttatgt aatttggagc atctattgga tctaaagttt 240
gtttccaggt gttttgaagt cttctgcatc tattgtcagt caaaccacat tgaagaacct 300
tatgtcagca tcaccaagaa gcggcagata ccaaaaaatg gccactcaga ggaaattgag 360
aaggaagtgg gccaggcaga gggcaagcta ttcacccacc gatctgcatt cagccgggca 420
tcggtgatcc aggctttcct gggctcagcc ccacagctga ccctgcagct gtacataagt 480
gtcttgcagc aggatgtcag tatcggacga tgtctgttca tggtcctttc cctattgtcc 540
attgtgtacg gagccttgcg ctgtaacatc ctagccatca agatcaaata cgatgaatat 600
gatgtcaagg tgaagcccct ggcctatgtc tgtatcttcc tctggaggag ctttgagatt 660
gtcacccgag tcattgtcct ggtcctcttt acctctgtcc tgaaggcctg ggtggtcata 720
gacatactca tcaacttcct cggcttcctc ttctacccct ggatcctctt ctggtgcagt 780
ggctccccct tccctgagaa ctttgagaag gccttcagtc ggctgggcac caccattgtg 840
ctgtgcttcc tcaccctcct ctacgccggg atcaacatgt tctgctggtc ggcggtgcag 900
ctgaaaatca acaaccccga cctcatcagc aagtctcaga actggtaccg gctcctggtg 960
tactacatgg tgaggttcat cgagaacgcc ttcctcctcc tcatgtggta tctttacaag 1020
actgacatct atatgtatgt gtgtgcaccc ctgctgatgc tgcagttgct cattgggtac 1080
tgcacggcca ttctgttcat ggttgtgttc tatcagttct tccacccttg caaaaagctc 1140
ttttccccca atgcttctga aagctttcag gagtggctaa agtgtgcctg ttgtaaccgc 1200
aggcggcggg aatcctgcga gtctgcagaa aatacagacc taaggtcacc cacagacaga 1260
gaggagaccc cttctagcag taaaataagt tccatgccta gccagatctt gaatactgat 1320
gagctctctt ctgcttaa 1338
<210>30
<211>4297
<212>DNA
<213>牛
<400>30
atggccgtgg cgctgtggtt cttgtggcct ctcctcctct gcagcccttg cgtgctcatc 60
cagatccctg aggaatatga aggacaccat gtgatggaac cccccatcat cacggagcag 120
tctccccggc gtgtggtcgt cttccccaca gatgacgtca gcctcaagtg tgaggccagc 180
ggcaaacccg aagtgcagtt tcgctggact cgggatggca tcctcttcaa acccagagag 240
gaactgggca tgatcgtgaa ccaggtgccc cattctggct ccttcagcat cacgggcaac 300
agcagcaact ttgcccagag cttccagggc acctatcgct gctttgccag caacaagctg 360
ggcaccgcca tgtcccacga gatccagctc atggccgagg gtacccccaa gtggccaaag 420
gagacagtga aacctgttga ggtcgaggaa ggggagtcgg tgattctccc ttgccacccg 480
ccccccagtg cagagccact ccggatctac tggatgaaca gcaagatctt gcacatcaaa 540
caggatgagc gggtgaccat gggccagaat ggcaacctct actttgctaa tgtgctcacc 600
tcagacaacc actcagacta catctgtcac gcccacttcc ctggcacccg aaccatcatt 660
caaaaggaac ccattgacct ccgggtcaaa gcgaccaaca gcatgatgga cagaaaacca 720
cacttgctct tccccaccaa ttccagcagc cacctggtgg ccctgcaggg gcagcccttg 780
atcttggagt gcatagctga gggcttcccc acgcccacca tcaagtggct gcgcccaagc 840
ggccccatgc cagccgaccg ggtcacctac cagaaccaca acaagacgct gcagttgctg 900
aacgtgggtg aggaggacga cggcgagtac cgctgcctgg ctgagaactc gctgggcagc 960
gaccgccacg cctactacgt caccgtggag gctgcaccat actggctaca caagccccag 1020
agccatctgt acgggccagg ggagactgcc cgcctagact gtcaagtgca gggcaggccc 1080
caaccggagg tcacctggag aatcaatggg atccctgtgg aggagctggg caaggaccag 1140
aaataccgga tccaccatgg agccctggtc ctgagcaatc tgcagcccag tgacactatg 1200
gtgacccagt gtgaggcccg caaccgccac gggctcctgc tggccaatgc ctacatctat 1260
gttgtggagc tgccagccaa gatcctgacc ccagacaatg agacatacat ggcagtccag 1320
ggcagcaccg cctaccttct gtgcaaggcc ttcggagccc ctgtgcccag cgtccagtgg 1380
ctggacaggg aaggaaagac agtgctgcag gacgagcgct tcttccccta caccaacggg 1440
accctgggca tccgagacct ccagaccaat gacactgggc actacttctg ccaggctgcc 1500
aacgaccaaa gcaacgtgac cattgtggct aacctgcagg tcaaagatgc cactcggatc 1560
atgcaggggc cccgcagtgc aatcgagaag agaggctccc gagtgatgtt cacatgccag 1620
gcctcctttg acccctccct gcagcacagc accacctggc gcagggatgc tctcgacctg 1680
caggagttgg gggacagtga caagtacttc atagaagacg agcgcttggt catccacagc 1740
ctggactaca gtgaccaggg caactacagc tgcgtggcca gcaccaagct ggacgtggtg 1800
gagagccggg cagagctgct ggtggtcggg agccccggac ctgtgcccca gctggagctg 1860
tctgatcacc acctgctgaa gcagagccag gtgcgcctgt cttggagccc agctgatgac 1920
cataacgccc ccattgagaa gtatgacatt gaatttgagg acaaggagat ggcacccgag 1980
aagtggtaca gcctgggcaa ggtgcccgga aaccagacct ccaccaccct caagctgtcg 2040
ccttatgtcc actatacctt tcgagtcact gccatcaaca aatatggccc tggggagccc 2100
agcccggact ctgagactgt ggtcacgccg gaggcagccc cagagaagaa ccccgtggac 2160
gtgaaggggg aaggaaatga gaccaacaac atggtcatca cttggaagcc gctgcggtgg 2220
atggactgga atgcccccca ggttcagtat cgagtgcagt ggcgccccca gaagatgcag 2280
ggggcctggc aggaacagat cgtcagtgac cccttcctgg tggtgtccaa tacatctacc 2340
tttgtgccgt atgagatcaa agtccagacc gtcaacagcc agggcaaggg ccctgagccc 2400
cagatcacca tcggctactc tggagaggac tacccccagg caagccctct gctggaaccc 2460
gtcaaggccc tcaattcaag cactgtgctg gtcaggtggc agtctgtgga cccagcccag 2520
gtcaaaggcc acctccgggg atacaatgtg acgtactggt gggaaggcag tcagaggaag 2580
cacaacaaga ggcacgtcca caaaggccac gtggtggtgc cagccaatgc caccagcacc 2640
atcctgggag gcctgcggcc ctatagctcc tactgggtag aggttcaggc ctttaacggg 2700
aggggactgg ggcctgccag tgggatgacc ttcaacaccc ctgagggagt gcctggacac 2760
cctgaggcgt tgcacctgga gtgccagtca gataccagcc tgctgctgca ctggcagcct 2820
ccgctcagcc ataatggtgt gctcacgggc tacgtgctct cctaccaacc tttgaatgac 2880
gggagcaagg agcagttgtc ctttgacctc ccggaccctg agctgcggac acacaacctg 2940
accaacctca gcccccgcct gcggtaccga ttccagctgc aggccaccac gagggagggc 3000
ccgggggagg cgatcgtacg ggaaggaggc accatggcct tgtccgggat gccggacttt 3060
ggcaacatct ccgccatggc tggcgagaat tacagtgtgg tctcctgggt ccccaaagag 3120
ggccagtgca acttcgggtt ccagatctgg ttcaaagccc tgggggacga gaagctggtg 3180
gctcgtctcc caccgcagta cgtcagctac aaccagagct cctacacaca gtgggacctg 3240
cagcctgaca ccgactatga gatccagctg ctcaaggagc aggtgctcct gcaccagatg 3300
gcagtgaaga ccaacggcac cggccgagtg aggctgcctc ccgctggctt tgccactgag 3360
ggctggttca tcggcttcat cagtgccatc gttgtcctgc ttcttgtctt actcatcctg 3420
tgcttcatta agcgcagcaa gggtggcaag tactcggtga aggacaagga ggacacccag 3480
gtggactcag aggcccggcc catgaaggac gaaaccttcg gcgagtacag gtccctggag 3540
agtgacaatg aggagaaggc ctttggtagc agccagccat cactcaacgg agacatcaag 3600
cccctgggca gcgatgacag cctggcggac tacggaggca gcgtggacgt ccagttcaat 3660
gaggatggct ccttcatcgg ccagtacagt ggcaagaagg agaaggaggt ggcagggggc 3720
aatgacagct ccggggccac atcccccatc aaccccgccg ggaccctgga gtagcggggt 3780
ccagccaggc caggcagagc accacccagg gccaggccac ggggctatca gagatcacca 3840
tgatggccca gcccaaggcc tgtgctgggt ccctgaccct gggactgagg cccgtccttc 3900
tctccagtga gttcgggggc cgaggagggg atctcgctgc ctcaacgccc tcttctgact 3960
ccccagtccc cacttgattg ccaaaaccca gctgctctgc ttcttgggca cacactgctt 4020
tttcactcca gctcgggggc cactcacatg ccaggagtct tcaggtgctg cctcaccagc 4080
ctttgggcag ggcgaggctg tggttgaggc gaggaggcag gcacagctgt ggagggggtc 4140
tcctaaggac cagggttggc acctccagcc ccagccactc gttggccagt aggactggga 4200
caggggactg aagtcggtgt ccctgctgtc tgccccatct tctcagccat ctctgctcca 4260
actgggatgg gaactgaaca agctggccac gggtaca 4297
<210>31
<211>1101
<212>DNA
<213>牛
<400>31
atggtccctg agatgagtga acgccaagag ttccaagcct ccgattttgc ctacctcctg 60
gaaaactctt cctatgacta cggagaaaat gagacctact tctgctgtac ttccccaccc 120
tgcccacagg acttcagcct caacttcgac cgcaccttcc tgcccgtcct ctacagcctc 180
ctctttgtgc tggggcttct gggtaatggc atcgtggcag tcgtgctgct gagccagagg 240
gcggccctga gcagcaccga cacctttctg ctgcacttgg ctgtggccga tgcactgctg 300
gtgctgacac tccctctctg ggcagtggat gcagccatcc agtgggtctt tggctctggc 360
ctctgcaaag tggcgggtgc actcttcaac atcaacttct acgcaggggc cctcctgctg 420
gcctgtatca gcttcgatcg gtacctgagc attgtgcacg ccacccagct ctaccgccgg 480
ggccccccga ctcgcgtggc cctcacctgt gtggcagtct gggggctctg tctgctcttt 540
gcgctcccag acttcatctt cctgtcctcc caccatgaca accgcctcaa tgccacccac 600
tgccagtaca acttcccaca ggagggccac acagctctgc gcatcctgca gctggtggca 660
ggcttcctgc tgcccctgct ggtcatggcc tattgctatg cccgcatcct ggctgtgctg 720
ctggtctcca ggggccagcg gcggctcaga gccatgcggc tggtggtggt ggtggtggtg 780
gcctttgccc tctgctggac cccctaccac ctggtggtgc tggtggacac cctcatggac 840
ctgggggcct tagcccgtaa ctgcggcaga gaaagcagtg tggacatagc caagtcggtc 900
acgtcgggca tgggctacat gcactgctgc ctcaacccac tgctctatgc ctttgtgggt 960
gtcaagttcc gagagcggat gtgggtgcta ctcgtgcgtc tgggctgccc tgaccagagg 1020
tgccaccagc ggcagccatc agcttcccgc cgggaatcat cctggtctga gaccacagag 1080
gcctcctact caggcctgtg a 1101
<210>32
<211>2406
<212>DNA
<213>牛
<400>32
gaaaaactga tctgttttcc tctttctctt ggtcagtgtg ctggagaaga gaagcgagtt 60
ggtacgcgca cagtatttgt tggcaatcat ccagtttcag aaactgaagc atacattgca 120
caaaaatttt gtgataatag aataatctca tctaagtata cactttggaa tttcctccca 180
aagaatctgt ttgaacagtt tagaagaatt gcaaattttt attttcttat aatttttctt 240
atacaggtaa cagtagacac accaactagc ccaattacca gtggacttcc acttttcttc 300
gttataactg ttacagccat caagcaggga tatgaggatt ggctgaggca cagggccgac 360
aatgaagtca ataaaagcac tgtttacatt attgaaaatg caaagcgagt gaaaaaagag 420
agtgaaaaaa tcaaggtcgg tgatatagta gaagtacagg cagatgaaac ctttccctgt 480
gatcttattc ttctgtcatc ctgcacagtt gatggaacct gttatgttac cacagccagt 540
cttgatgggg aatcgaattg caagacacat tatgcggtac gtgataccat tgaactgcgt 600
acagtcgaat ccattgataa cctcagagca gcaattgaat gtgaacagcc tcaacctgac 660
ctctacaagt ttgttggccg aatcaatatc tatagtaata gtattgaagc tgttgccagg 720
tctttgggac ctgaaaatct cttgttgaaa ggagctacac taaaaaatac caagaagata 780
tatggagttg ctgtttacac tggaatggaa accaaaatgg cattgaacta ccaagggaaa 840
tctcagaaac gttctgctgt tgaaaaatcc attaatgctt tcctgattgt gtatttattt 900
atcttactga ccaaagctgc aatatgcact actctaaagt atgtttggca aagtacccca 960
cataatgatg aaccttggta taaccaaaag acccagaaag aacgggaaac ttggaaggtt 1020
ttaaaaatgt tcactgactt cctgtcattt atggttctgt tcaactttat cattcctgtc 1080
tccatgtatg tcacagtaga aatgcaaaaa ttcttgggct ccttcttcat ttcatgggat 1140
aacgacttct atgatgaaga aattaatgaa ggagccctgg taaacacatc agaccttaat 1200
gaagaacttg gtcaggtgga ttatgtattt actgataaga ctggaacact tactgaaaac 1260
accatggaat tcattgaatg ctgcatagat gggcataagt ataaaggtgt agctcaggag 1320
actgatggac tctctcaaac tgatggaccc ttaccatatt tggacagagc tgataagaat 1380
cgagaagagc tctttctgcg tgccttgtgt ttatgtcaca ctgtagaagt taaaccaaat 1440
gatactgttg atggagttac agagtcatct gaattaacct atatgtcatc ttcaccagat 1500
gaaatagaaa gtgaaatcac aggaggacag aggtatggat tcacatttgt aggtgttcag 1560
aatggctata tgagagtaga gaaccaaaga aaagaaatag aagagtatga acttcttcac 1620
accttaaact ttgatgctgt ccgccgtcgt atgagtgtaa ttgtgaagac tcaaacagga 1680
gatatacttc tcttttgtaa aggagccgac tcagcagttt tccccagggt acaaaatcat 1740
gaaatcgact taattaaagt ccatgtggaa cataatgcga tggaggggta tcggacactt 1800
tgtatagcct tcaaagaaat tgctccagat gattatgaaa gagttaacag acagctcata 1860
gaggcaaaaa tggccttaca agacagagaa gaaaaaatgg aaaaggtttt cgatgagatt 1920
gagacagaca tgcatttaat tggagccact gcagtggaag acaagctaca agatcaagcc 1980
gctgagacca ttgaagccct gcatgccgca ggtctgaaag tctgggtgct tactggcgac 2040
aagatggaga ctgcaaaatc cacctgctat gcctgccgcc ttttccaaac caacaccgag 2100
ctcttggaac tgaccaccaa gacaattgaa gaaagcgaaa ggaaagagga tcgattacat 2160
gagttgttga ctgaatatcg taagaagctg ctgcatgaat ttcctaaaag tactagaagc 2220
cttaaaaaag cgtggacaga acatcaggaa tacggattaa tcattgatgg ctccactctg 2280
tctcttatat taaactctag tcaagactct ggttctaaca attacaaaag cattttccta 2340
cagatctgca tgaagtgcac agcagtgctc tgctgtcgga tggccccgtt acagaaagct 2400
caggta 2406
<210>33
<211>1020
<212>DNA
<213>牛
<400>33
tcagatgtct ttgggaacga attcagtata ttaagatcac cagggtctgt tgttttccgg 60
aatggaaatt ggcctattcc aggagagcga atcccagacg tggctgcatt gtccatgggc 120
ttctctgtga aagaggatct ttcttggccg ggccttgcag taggtaacct attccaccgt 180
cctcgggcta ctgttatggt gatggtgaaa ggagtggaca agcttgctct acccccaggc 240
agtgtcattt cgtacccttt ggagaatgca gttcctttta gtcttgacag cgtggcaaat 300
tccattcact ccttattttc tgaagaaact cctgtggttt tgcagttggc tcccagtgag 360
gaaagagtgt acatggtggg gaaggcaaac tcagtttttg aagatctctc agtaacgctc 420
agacagctcc gcaatcgact gtttcaagaa aactctgttc tcacttcact tcccctcaat 480
tctctgagta ggaacaatga agttgatctc ctttttcttt ctgaactgca agtgctacgt 540
gatatttcaa gtttgttgtc tcgacataag catctagcca aggatcattc tcctgattta 600
tactcactgg agctagcagg cctggatgaa attgggaaac actatgggga agactctgaa 660
caatttagag atgcctctaa gatccttatt gatgctctgc aaaagtttgc agatgacatg 720
tacaatctct atggtgggaa tgcagtggta gagttagtga ctgtcagatc attcgacaca 780
tcccttgtga ggaagacgag gaatatcctt gagacaaaac aagtgaagga cccctcaact 840
acctataacc ttgcatataa atataatttt gaatatcccg tggttttcaa cctggtactt 900
tggataatga tcggcttggc cttgactctg attgtcacct gttacaatat ttggaacatg 960
gatcctggat atgatagcat catttatagg atgacaaacc agaagattcg aatggattga 1020
<210>34
<211>1857
<212>DNA
<213>牛
<400>34
agtagctcgc ggagagggag gagaaagcaa gttccggatc cctgcctatc ccggcccaac 60
ctttgctcca gcgatcatgg ctgccgagga tgtggcggcg accggcgcag acacgagcga 120
gctcgagagc ggcgggctgc tgcaagagat tttcacgtcg ccgctcaacc tgctgctcct 180
tggcctttgc atctttctgc tctacaagat cgtgcgcggg gaccagccgg cggccagcga 240
tagcgacgac gacgagccgc ccccgctgcc ccgccttaag cggcgcgact tcacccctgc 300
cgagctgcgg cgcttcgacg gcgtacagga cccgcgtata ctcatggcca tcaatggcaa 360
ggtgttcgac gtaaccaaag gccgcaagtt ctacgggcct gaggggccgt atggagtctt 420
tgctggaaga gatgcatcca gaggccttgc caccttttgc ctggataagg aagcgctgaa 480
ggatgagtac gatgaccttt ccgacctcac tcctgcccag caggagaccc tgagtgactg 540
ggactctcag ttcactttca agtaccatca tgtgggcaaa ctgctgaagg acggggagga 600
gcccaccgtg tactcagacg aggaggagcc aaaagatgag agcactcgga agaatgatta 660
aggccttcag cggaagcata tctatttttg tattttgcag aatcatttgt aacattccag 720
tctgtcttta aaacatggtg atttcaatat ttagaaaagt tttgaacttg ctgtacattt 780
ttttaattaa catcactagt gacactgata aagctaactc tgtcttagaa tgcatgatat 840
gtttgtgtgt cacaaatcca gaaagtgaag tgcagtgctg taagacaaat gttattatgg 900
tttttcttct atttgtagtc agtgcaggct gaattggaac ttgtatttcc tgagagacag 960
gtaagacatg agtattcccc ccaaacaggt ttaaaggtta aatgtgtgaa gtccttcaag 1020
cgtcaagaaa caaagaatgg actttgagtc atgatattct ctaaagatag aaaatccttt 1080
atttctcgat tgacctaact gcatgatttc tgttttctct acctctaaag caaatctgca 1140
gtgtcccaaa ggctttggta ttaattaaag agagcagtcc agtacaaaat gaaatctcaa 1200
agctggactc aatcacaggt aacctacttt tctgtttggg gacagcatca ttgtcctgtg 1260
ctctttggaa cactcagatg cccttactta acagtaatct ccaatgagcc tgaaaatagg 1320
atctcaacat tccaaagcaa gctttggcga aaatcagctg gcttgcctaa aaaccaaaaa 1380
tacatgaata agattgtagg actattttcc ccacccctgt gttcttggtt atttcacatg 1440
attggacatg cgaggggacc gtgtaggaca ggagcagatt gttctctaag agccttcaca 1500
cacacccctg aagaatgagg aaaccgtaca cattactggc caagtggttt ttaaagtgta 1560
ttcataacct aacagttatt cttctgttgt tacaaaacta tagccactgc aagagttgta 1620
gtcaagtgtc ttggtctttg atattggtct tggttaacaa taaacttagc ttaagtagac 1680
tgtacagttg tatgactttg taaaagtatt atatgaataa ctagtgaggt ttcaaactct 1740
tgtaattgta gttgaatagt cattgtattt tcttgtgaac tgtgtttaat ggttttacct 1800
caaatcagaa aacaaaatga agtgctttgg tcagttaata aaatggtttt acccagt 1857
<210>35
<211>642
<212>DNA
<213>牛
<400>35
tacacatcta ccatgtcctt gctcatcaac agcgccaatt gccaaatagt aggttttgca 60
gtagccacta ttggatggat cctcggcacc actgccatgg gcttcgtgga gtggcgagta 120
tggtatctag acaacgcctc acaattctct ggtctggcct gcatgggaat gtggagagtc 180
tgtgtcttcc gtcaaaccaa catcaccaca gctacctcat gtcacagtta cagctaccat 240
gatacttacc tacctcttga tatccgtgtt tctcaacacc tcttactgat ggccagcatt 300
ctaggactct tggggaaagc ctctgttact tttgcactta aaaatgtgtc catgggaatt 360
cttgagaata ctactaccta caaagcattt gtcatttcag gaattctcca catagctgct 420
ggtatctgta tctcagttgc tgtcatctgg aattaccact ctgtgatgac tgaagagggc 480
attgtcttcc caccatcttt caatataccc ttcaagccat atgctcagaa aattggcaac 540
actgttatag tggcatgtct agctgccttt gcgctgttct taggtgggtg gttttttctc 600
tcttacaaat tacccctgga taaccaggtg catcctgaag ta 642
<210>36
<211>1077
<212>DNA
<213>牛
<400>36
atggcgacct cagctgatgg gattgaaact gtgggtgaag ttgctgggac cacaccctac 60
gactatgagg cggcactgcc gtgcgagaag agcaacgtca aggagctggc ggcccagttc 120
ctgcccccgc tgtactccct ggtgtttgtg accggcctgc tgggcaacgt ggtggtggtg 180
gtgatactca caaagtacaa gcggctccgg atcatgacca acatctacct gctcaacctg 240
gccatttctg acgtgctctt cctattcacg ctgccattct ggattcacta tgttaggtgg 300
aacgagtggg tgtttggcca ccgcatgtgt aagttgctct ccgggctcta ttacatgggc 360
ttgtacagtg agatcttttt catcatcctc ttgaccatag accggtatct tgccatcgtc 420
cacgccgtgt ttgcccttcg agcccggaca gtcacttttg gtattgttac cagcatcttc 480
acctgggtcc tggcagggct agcagccctc cctgaatttt tctttcatga gacccaagag 540
gaggctggac agactttctg cagtcctctt tacccagagg ataatgaaaa tgcctggaag 600
cgattccatg ctctgagaat gaatatcctg ggtctcgctc tgcctctgct tgttatggcc 660
atctgctatt caggaattat taaaacactg ctgagatgcc ccagtaaaaa aaaatacaaa 720
gccattcgac ttatttttgt aattatggtg gtcttcttta ttttctggac accctacaat 780
ctggttgtcc tactctttgc ttttcaaatg cacttgaagg ctgattgtga acagagcaga 840
cagctggacc tggccatgct ggtgacagag gtgatcgcct acacgcactg ctgtgtcaac 900
cccgtgatct atgccttcgt tggtgagagg ttccggaagc acctccgcca ctttttccac 960
agatatatgg ccacctacct gggaaaattc atgccatttc ttcctagtga aaaactggaa 1020
agaaccagct ctgtctcccc atcaacaggg gagcaggaac tctctgctgt attttag 1077
<210>37
<211>1083
<212>DNA
<213>牛
<400>37
ctcaccatgc acaccaccct ccctgaatca acttcagaaa acttcgagta ttatgacctt 60
gcagaagcct gtgatatggg ggacatcgtg gccttgggaa ctgtcttcgt ggtcatactc 120
tactccctcg tctttgcctt tggcctggtg ggaaatttgc tggtggtgtt tgccctcatc 180
aacagccaga ggtccaaaag tattactgac atttacctcc tgaacctggc cttgtctgat 240
ctgctctttg tagccacctt gcccttctgg actcactatg tgataaatga gcaaggcctt 300
caccacgcca cgtgcaaact catcactgcc ttcttcttca ttggattttt tggaggcata 360
ttcttcatca ccgttatcag cgtcgacagg ttcctggcca ttgtgctggc tgccaactcc 420
atgagcaaca ggaccgtgca gcatggtgtc accaccagcc tcggcgtctg ggcagctgcc 480
atcttggtgg ccacaccgca gttcatgttc accagagaga aagagaacga atgctttggc 540
gactaccctg agatcctgca ggaaatctgg cctgtgatcc tcaacacgga aataaatttt 600
cttggcttcc tgctccccct gctcattatg agttactgtt acttcagaat catgcagaca 660
ttgttttcct gcaagaacca caagaaagct aaagccatca ggctgatctt tctggtggtc 720
gtcgtttttt tcctcttctg gacaccctat aatgtcatga ttttcttaca gacactcaat 780
ctctatgact tctttcccaa atgtgatgtg aagagagatc tgaagttggc catcagtgtg 840
acagagacaa ttgcatttag ccactgttgc ctcaatcccc ttatctatgc atttgctgga 900
gagaagttca gacgatacct ttaccgtctg tacaggaaat gcctggctgt cctgtgttgc 960
catcctgacc acctcagttt ctcttcatct ctgtctgaat cacaaaggag caggcgggaa 1020
agtgttctga gcagcaattt tactcattac accagcgatg gagatgcgtc catccttctc 1080
tga 1083
<210>38
<211>459
<212>DNA
<213>牛
<400>38
atgtggtccc tcaaatcgtt cttgtgctta tccattgttg tttcctgtgt ctacgcctta 60
atgtttactt ctctgacaga gaaagttaaa gaaatccagt ggaaggtgct ctgcagagga 120
cactttttaa ttcagcagaa tctacaagag caagcccaag actggcttga gatcacgttg 180
ctctggcttt tcttcattgt gctgatgtac gtgacagtga agttggcagg agagaatggc 240
gagagtagag tgcagacttc tcatgccctt cagggccgtt catttggctt tcttggaaat 300
aaaaaggtaa agacttcctc taaagaagtc tacatgttcc ataccttaac cctgctcgag 360
atggaccttg tgaaatttgt gtgcagggtg cagaatctga aactcgccac atcaaccagc 420
ggtaacatca accccctcaa tgtcaaggtt cctgcagat 459
<210>39
<211>1041
<212>DNA
<213>牛
<400>39
atggcccgtc ctggccagcg ttggctcggc aagtggcttg tcgcgatggt cgtgttggcg 60
ctatgccggc tcgccacgcc gctggccaag aatctggagc ccgtgtcctg gagctctctc 120
aaccccaagt tcctgagtgg gaaggggctg gtgatttacc caaagattgg agacaagctg 180
gacatcatct gcccccgagc agaagctggg cggccctatg agtactacaa gctgtatctg 240
gtgcggcctg agcaggcagc ggcctgtagc actgtgcttg accccaatgt gctagtcaca 300
tgcaataggc cagagcagga aatccgcttc accatcaagt tccaggaatt cagccccaac 360
tacatgggcc tggagttcaa gaagcaccat gattactata ttacctctac atccaatggg 420
agtctggagg gactggagaa ccgggaggga ggtgtgtgcc gcacacgcac catgaagatc 480
gtcatgaagg ttgggcaaga ccccaatgct gtgacacccg agcagctgac taccagccgg 540
cccagcaagg aggcagacaa cactatcaag atggccacac aggcccctgg tggtcggagt 600
tccatgggtg actctgacgg caagcatgag actgtgaacc aggatgagaa aagtggctct 660
ggtgggaatg gaggcagtag cggggacccc gacagcttct tcaactccaa ggtggcgttg 720
tttgcagctg tgggcgctgg ctgcgtcatc ttcctactca tcatcatctt cctgaccatc 780
ctgctactga agctgcgcaa gcggcaccgc aagcacacac agcagcgggc gcccgccctc 840
tcactcagca ccctggccag tcccaagggg ggcagtggca ctgcgggcac cgagcccagc 900
gacatcatca tccccttacg gactacagag aacaactact gcccccacta tgagaaggtg 960
agtggggact acgggcaccc cgtctacatc gtccaggaga tgccgcccca gagcccagcg 1020
aacatctact acaaggtctg a 1041
<210>40
<211>898
<212>DNA
<213>牛
<400>40
atgagcatct tgctgcccaa catggcggag ttcgatacca tctcggaact ggaggaggag 60
gaggaagaag aagcggcaac gtcgtcgtcg tcgtcgccgt cgtcgtcgtc gtcggtatca 120
gggcctgacg atgacgagga agatgaggag gaggaggagg aagaaaacga agaggaggag 180
gaggaagaag aggagcaggt ggaggaaacg ccgcccccgc ctcgggtagt gagcgaagag 240
catctacgga gatatgcccc cgaccctgta ttggtgcggg gcgccggcca catcactgtg 300
tttggcttga gcaacaagtt tgatactgaa tttccctcag ttctaacagg gaaggtggcc 360
ccagaagaat ttaagaccag cattggccgt gtgaatgcat gtttgaaaaa ggctctccca 420
gtcaatgtga aatggttgct ctgtggttgt ctctgctgct gttgcacatt gggttgcagc 480
ctgtggcctg ttatttgtct caacaaaaga accagaagat caattcagaa gttgttagaa 540
tgggaaaata acagattgta tcacaagctt gctttgcact ggaagttgac taaaaggaaa 600
tgtgaaacta gcaatatgat ggagtatgta atactaatag aattcttacc aaaatatccc 660
atattccgac ctgactgagg aattttattc agtcacttct gttttacctg tcatttccta 720
cccttagtgc cttgtagatg attttggaat gaagatggtc tcctttgctg ttttcaattt 780
attctttata atcgtagaat attctcctca cacttcattt gtgttggttt aagaagaaat 840
tttgcacatc ctttttgttg ttgttaaatg aggcttgtat tttgcactgt caattttt 898
<210>41
<211>519
<212>DNA
<213>牛
<400>41
cagctcacga tgcgctctgt aatatggtta tttttttggc ctacgcttat ctcgtttgtc 60
tttgcctatg tgttttatgt tctgagagat gaagccgaag aactgccgtg gatggtgccc 120
agtggaaggc acttccgcgt tcggcagaat caaccagagt atgccccagg ctggtttggg 180
agcaagtggc actggctgtt aatcttcctc atgtttttgg tgatcctgaa gtttcctgga 240
ggcgatgacg aaagtaatgc gggcactcct cctggccgtc agggctgttc atctggctct 300
ccaggaagaa agaagataag ggattccccc tacaaagagt ctatgtgcgg tgccttaacc 360
cagtccgaga cgtcactgat gaaccttatg tccagggtga agaatatgaa actcactgcg 420
gcaaccggtg atcaatgcca atgtcccaat atcgaggttc ctggtgacgc acggaataat 480
gttacaatac ttgaggtatg ggacaccgga gaccctgat 519
<210>42
<211>276
<212>DNA
<213>牛
<400>42
accatgctga aatctctttc ttgcattttg tttctaaaag catgcgttcc agtggagggt 60
caggtgctaa cgccttgcaa gcaggggcaa gatcttaaca aggatgaatg tttgaaatac 120
aaatgctgtt actcttcaat cgagaccgct acggttagct gttttgcccc tctgagagac 180
agtaagttaa tccttttaca gatgtttggg tttggtgcga tgagcatggt cttcctggga 240
tgtctgccca tgtattgctg ctctttttgc tggaag 276
<210>43
<211>387
<212>PRT
<213>人
<400>43
Met Val Phe Ala Phe Trp Lys Val Phe Leu Ile Leu Ser Cys Leu Ala
1 5 10 15
Gly Gln Val Ser Val Val Gln Val Thr Ile Pro Asp Gly Phe Val Asn
20 25 30
Val Thr Val Gly Ser Asn Val Thr Leu Ile Cys Ile Tyr Thr Thr Thr
35 40 45
Val Ala Ser Arg Glu Gln Leu Ser Ile Gln Trp Ser Phe Phe His Lys
50 55 60
Lys Glu Met Glu Pro Ile Ser Ile Tyr Phe Ser Gln Gly Gly Gln Ala
65 70 75 80
Val Ala Ile Gly Gln Phe Lys Asp Arg Ile Thr Gly Ser Asn Asp Pro
85 90 95
Gly Asn Ala Ser Ile Thr Ile Ser His Met Gln Pro Ala Asp Ser Gly
100 105 110
Ile Tyr Ile Cys Asp Val Asn Asn Pro Pro Asp Phe Leu Gly Gln Asn
115 120 125
Gln Gly Ile Leu Asn Val Ser Val Leu Val Lys Pro Ser Lys Pro Leu
130 135 140
Cys Ser Val Gln Gly Arg Pro Glu Thr Gly His Thr Ile Ser Leu Ser
145 150 155 160
Cys Leu Ser Ala Leu Gly Thr Pro Ser Pro Val Tyr Tyr Trp His Lys
165 170 175
Leu Glu Gly Arg Asp Ile Val Pro Val Lys Glu Asn Phe Asn Pro Thr
180 185 190
Thr Gly Ile Leu Val Ile Gly Asn Leu Thr Asn Phe Glu Gln Gly Tyr
195 200 205
Tyr Gln Cys Thr Ala Ile Asn Arg Leu Gly Asn Ser Ser Cys Glu Ile
210 215 220
Asp Leu Thr Ser Ser His Pro Glu Val Gly Ile Ile Val Gly Ala Leu
225 230 235 240
Ile Gly Ser Leu Val Gly Ala Ala Ile Ile Ile Ser Val Val Cys Phe
245 250 255
Ala Arg Asn Lys Ala Lys Ala Lys Ala Lys Glu Arg Asn Ser Lys Thr
260 265 270
Ile Ala Glu Leu Glu Pro Met Thr Lys Ile Asn Pro Arg Gly Glu Ser
275 280 285
Glu Ala Met Pro Arg Glu Asp Ala Thr Gln Leu Glu Val Thr Leu Pro
290 295 300
Ser Ser Ile His Glu Thr Gly Pro Asp Thr Ile Gln Glu Pro Asp Tyr
305 310 315 320
Glu Pro Lys Pro Thr Gln Glu Pro Ala Pro Glu Pro Ala Pro Gly Ser
325 330 335
Glu Pro Met Ala Val Pro Asp Leu Asp Ile Glu Leu Glu Leu Glu Pro
340 345 350
Glu Thr Gln Ser Glu Leu Glu Pro Glu Pro Glu Pro Glu Pro Glu Ser
355 360 365
Glu Pro Gly Val Val Val Glu Pro Leu Ser Glu Asp Glu Lys Gly Val
370 375 380
Val Lys Ala
385
<210>44
<211>171
<212>PRT
<213>人
<400>44
Met Trp Thr Leu Lys Ser Ser Leu Val Leu Leu Leu Cys Leu Thr Cys
1 5 10 15
Ser Tyr Ala Phe Met Phe Ser Ser Leu Arg Gln Lys Thr Ser Glu Pro
20 25 30
Gln Gly Lys Val Pro Cys Gly Glu His Phe Arg Ile Arg Gln Asn Leu
35 40 45
Pro Glu His Thr Gln Gly Trp Leu Gly Ser Lys Trp Leu Trp Leu Leu
50 55 60
Phe Ala Val Val Pro Phe Val Ile Leu Gln Cys Gln Arg Asp Ser Glu
65 70 75 80
Lys Asn Lys Glu Gln Ser Pro Pro Gly Leu Arg Gly Phe Pro Phe Arg
85 90 95
Thr Pro Leu Lys Lys Asn Gln Asn Ala Ser Leu Tyr Lys Asp Cys Val
100 105 110
Phe Asn Thr Leu Asn Glu Leu Glu Val Glu Leu Leu Lys Phe Val Ser
115 120 125
Glu Val Gln Asn Leu Lys Gly Ala Met Ala Thr Gly Ser Gly Ser Asn
130 135 140
Leu Lys Leu Arg Arg Ser Glu Met Pro Ala Asp Pro Tyr His Val Thr
145 150 155 160
Ile Cys Lys Ile Trp Gly Glu Glu Ser Ser Ser
165 170
<210>45
<211>346
<212>PRT
<213>人
<400>45
Met Ala Arg Pro Gly Gln Arg Trp Leu Gly Lys Trp Leu Val Ala Met
1 5 10 15
Val Val Trp Ala Leu Cys Arg Leu Ala Thr Pro Leu Ala Lys Asn Leu
20 25 30
Glu Pro Val Ser Trp Ser Ser Leu Asn Pro Lys Phe Leu Ser Gly Lys
35 40 45
Gly Leu Val Ile Tyr Pro Lys Ile Gly Asp Lys Leu Asp Ile Ile Cys
50 55 60
Pro Arg Ala Glu Ala Gly Arg Pro Tyr Glu Tyr Tyr Lys Leu Tyr Leu
65 70 75 80
Val Arg Pro Glu Gln Ala Ala Ala Cys Ser Thr Val Leu Asp Pro Asn
85 90 95
Val Leu Val Thr Cys Asn Arg Pro Glu Gln Glu Ile Arg Phe Thr Ile
100 105 110
Lys Phe Gln Glu Phe Ser Pro Asn Tyr Met Gly Leu Glu Phe Lys Lys
115 120 125
His His Asp Tyr Tyr Ile Thr Ser Thr Ser Asn Gly Ser Leu Glu Gly
130 135 140
Leu Glu Asn Arg Glu Gly Gly Val Cys Arg Thr Arg Thr Met Lys Ile
145 150 155 160
Ile Met Lys Val Gly Gln Asp Pro Asn Ala Val Thr Pro Glu Gln Leu
165 170 175
Thr Thr Ser Arg Pro Ser Lys Glu Ala Asp Asn Thr Val Lys Met Ala
180 185 190
Thr Gln Ala Pro Gly Ser Arg Gly Ser Leu Gly Asp Ser Asp Gly Lys
195 200 205
His Glu Thr Val Asn Gln Glu Glu Lys Ser Gly Pro Gly Ala Ser Gly
210 215 220
Gly Ser Ser Gly Asp Pro Asp Gly Phe Phe Asn Ser Lys Val Ala Leu
225 230 235 240
Phe Ala Ala Val Gly Ala Gly Cys Val Ile Phe Leu Leu Ile Ile Ile
245 250 255
Phe Leu Thr Val Leu Leu Leu Lys Leu Arg Lys Arg His Arg Lys His
260 265 270
Thr Gln Gln Arg Ala Ala Ala Leu Ser Leu Ser Thr Leu Ala Ser Pro
275 280 285
Lys Gly Gly Ser Gly Thr Ala Gly Thr Glu Pro Ser Asp Ile Ile Ile
290 295 300
Pro Leu Arg Thr Thr Glu Asn Asn Tyr Cys Pro His Tyr Glu Lys Val
305 310 315 320
Ser Gly Asp Tyr Gly His Pro Val Tyr Ile Val Gln Glu Met Pro Pro
325 330 335
Gln Ser Pro Ala Asn Ile Tyr Tyr Lys Val
340 345
<210>46
<211>1566
<212>PRT
<213>人
<400>46
Pro Ser Ser Ala Ser Ser Leu Gly Ile Ala Val Ser Leu Gly Arg Pro
1 5 10 15
Val Leu Ser Arg Ser Ser Ser Gly Thr Val Asp Leu Leu Glu Glu Val
20 25 30
Gly Leu Gln Ile Arg Asp Thr Ala Phe Ser Ser Thr Lys Leu Leu Glu
35 40 45
Ala Ile Ser Thr Val Ser Ala Gln Val Glu Glu Leu Ala Val His Glu
50 55 60
Ile Lys Met Asp Pro Ser Met Gly Val Asn Ser Val Thr Ile Ser Val
65 70 75 80
Glu Gly Met Thr Cys Asn Ser Cys Val Trp Thr Ile Glu Gln Gln Ile
85 90 95
Gly Lys Val Asn Gly Val His His Ile Lys Val Ser Leu Glu Glu Lys
100 105 110
Asn Ala Thr Ile Ile Tyr Asp Pro Lys Leu Gln Thr Pro Lys Thr Leu
115 120 125
Gln Glu Ala Ile Asp Asp Met Gly Phe Asp Ala Val Ile His Asn Pro
130 135 140
Asp Pro Leu Pro Val Leu Thr Asp Thr Leu Phe Leu Thr Val Thr Ala
145 150 155 160
Ser Leu Thr Leu Pro Trp Asp His Ile Gln Ser Thr Leu Leu Lys Thr
165 170 175
Lys Gly Val Thr Asp Ile Lys Ile Tyr Pro Gln Lys Arg Thr Val Ala
180 185 190
Val Thr Ile Ile Pro Ser Ile Val Asn Ala Asn Gln Ile Lys Glu Leu
195 200 205
Val Pro Glu Leu Ser Leu Asp Thr Gly Thr Leu Glu Lys Lys Ser Gly
210 215 220
Ala Cys Glu Asp His Ser Met Ala Gln Ala Gly Glu Val Val Leu Lys
225 230 235 240
Met Lys Val Glu Gly Met Thr Cys His Ser Cys Thr Ser Thr Ile Glu
245 250 255
Gly Lys Ile Gly Lys Leu Gln Gly Val Gln Arg Ile Lys Val Ser Leu
260 265 270
Asp Asn Gln Glu Ala Thr Ile Val Tyr Gln Pro His Leu Ile Ser Val
275 280 285
Glu Glu Met Lys Lys Gln Ile Glu Ala Met Gly Phe Pro Ala Phe Val
290 295 300
Lys Lys Gln Pro Lys Tyr Leu Lys Leu Gly Ala Ile Asp Val Glu Arg
305 310 315 320
Leu Lys Asn Thr Pro Val Lys Ser Ser Glu Gly Ser Gln Gln Arg Ser
325 330 335
Pro Ser Tyr Thr Asn Asp Ser Thr Ala Thr Phe Ile Ile Asp Gly Met
340 345 350
His Cys Lys Ser Cys Val Ser Asn Ile Glu Ser Thr Leu Ser Ala Leu
355 360 365
Gln Tyr Val Ser Ser Ile Val Val Ser Leu Glu Asn Arg Ser Ala Ile
370 375 380
Val Lys Tyr Asn Ala Ser Ser Val Thr Pro Glu Ser Leu Arg Lys Ala
385 390 395 400
Ile Glu Ala Val Ser Pro Gly Leu Tyr Arg Val Ser Ile Thr Ser Glu
405 410 415
Val Glu Ser Thr Ser Asn Ser Pro Ser Ser Ser Ser Leu Gln Lys Ile
420 425 430
Pro Leu Asn Val Val Ser Gln Pro Leu Thr Gln Glu Thr Val Ile Asn
435 440 445
Ile Asp Gly Met Thr Cys Asn Ser Cys Val Gln Ser Ile Glu Gly Val
450 455 460
Ile Ser Lys Lys Pro Gly Val Lys Ser Ile Arg Val Ser Leu Ala Asn
465 470 475 480
Ser Asn Gly Thr Val Glu Tyr Asp Pro Leu Leu Thr Ser Pro Glu Thr
485 490 495
Leu Arg Gly Ala Ile Glu Asp Met Gly Phe Asp Ala Thr Leu Ser Asp
500 505 510
Thr Asn Glu Pro Leu Val Val Ile Ala Gln Pro Ser Ser Glu Met Pro
515 520 525
Leu Leu Thr Ser Thr Asn Glu Phe Tyr Thr Lys Gly Met Thr Pro Val
530 535 540
Gln Asp Lys Glu Glu Gly Lys Asn Ser Ser Lys Cys Tyr Ile Gln Val
545 550 555 560
Thr Gly Met Thr Cys Ala Ser Cys Val Ala Asn Ile Glu Arg Asn Leu
565 570 575
Arg Arg Glu Glu Gly Ile Tyr Ser Ile Leu Val Ala Leu Met Ala Gly
580 585 590
Lys Ala Glu Val Arg Tyr Asn Pro Ala Val Ile Gln Pro Pro Met Ile
595 600 605
Ala Glu Phe Ile Arg Glu Leu Gly Phe Gly Ala Thr Val Ile Glu Asn
610 615 620
Ala Asp Glu Gly Asp Gly Val Leu Glu Leu Val Val Arg Gly Met Thr
625 630 635 640
Cys Ala Ser Cys Val His Lys Ile Glu Ser Ser Leu Thr Lys His Arg
645 650 655
Gly Ile Leu Tyr Cys Ser Val Ala Leu Ala Thr Asn Lys Ala His Ile
660 665 670
Lys Tyr Asp Pro Glu Ile Ile Gly Pro Arg Asp Ile Ile His Thr Ile
675 680 685
Glu Ser Leu Gly Phe Glu Ala Ser Leu Val Lys Lys Asp Arg Ser Ala
690 695 700
Ser His Leu Asp His Lys Arg Glu Ile Arg Gln Trp Arg Arg Ser Phe
705 710 715 720
Leu Val Ser Leu Phe Phe Cys Ile Pro Val Met Gly Leu Met lle Tyr
725 730 735
Met Met Val Met Asp His His Phe Ala Thr Leu His His Asn Gln Asn
740 745 750
Met Ser Lys Glu Glu Met Ile Asn Leu His Ser Ser Met Phe Leu Glu
755 760 765
Arg Gln Ile Leu Pro Gly Leu Ser Val Met Asn Leu Leu Ser Phe Leu
770 775 780
Leu Cys Val Pro Leu Glu Phe Phe Gly Gly Trp Tyr Phe Tyr Ile Gln
785 790 795 800
Ala Tyr Lys Ala Leu Lys His Lys Thr Ala Asn Met Asp Val Leu Ile
805 810 815
Val Leu Ala Thr Thr Ile Ala Phe Ala Tyr Ser Leu Ile Ile Leu Leu
820 825 830
Val Ala Met Tyr Glu Arg Ala Lys Val Asn Pro Ile Thr Phe Phe Asp
835 840 845
Thr Pro Pro Met Leu Phe Val Phe Ile Ala Leu Gly Arg Trp Leu Glu
850 855 860
His Ile Ala Lys Gly Lys Thr Ser Glu Ala Leu Ala Lys Leu Ile Ser
865 870 875 880
Leu Gln Ala Thr Glu Ala Thr Ile Val Thr Leu Asp Ser Asp Asn Ile
885 890 895
Leu Leu Ser Glu Glu Gln Val Asp Val Glu Leu Val Gln Arg Gly Asp
900 905 910
Ile Ile Lys Val Val Pro Gly Gly Lys Phe Pro Val Asp Gly Arg Val
915 920 925
Ile Glu Gly His Ser Met Val Asp Glu Ser Leu Ile Thr Gly Glu Ala
930 935 940
Met Pro Val Ala Lys Lys Pro Gly Ser Thr Val Ile Ala Gly Ser Ile
945 950 955 960
Asn Gln Asn Gly Ser Leu Leu Ile Cys Ala Thr His Val Gly Ala Asp
965 970 975
Thr Thr Leu Ser Gln Ile Val Lys Leu Val Glu Glu Ala Gln Thr Ser
980 985 990
Lys Ala Pro Ile Gln Gln Phe Ala Asp Lys Leu Ser Gly Tyr Phe Val
995 1000 1005
Pro Phe Ile Val Phe Val Ser Ile Ala Thr Leu Leu Val Trp Ile Val
1010 1015 1020
Ile Gly Phe Leu Asn Phe Glu Ile Val Glu Thr Tyr Phe Pro Gly Tyr
1025 1030 1035 1040
Asn Arg Ser Ile Ser Arg Thr Glu Thr Ile Ile Arg Phe Ala Phe Gln
1045 1050 1055
Ala Ser Ile Thr Val Leu Cys Ile Ala Cys Pro Cys Ser Leu Gly Leu
1060 1065 1070
Ala Thr Pro Thr Ala Val Met Val Gly Thr Gly Val Gly Ala Gln Asn
1075 1080 1085
Gly Ile Leu Ile Lys Gly Gly Glu Pro Leu Glu Met Ala His Lys Val
1090 1095 1100
Lys Val Val Val Phe Asp Lys Thr Gly Thr Ile Thr His Gly Thr Pro
1105 1110 1115 1120
Val Val Asn Gln Val Lys Val Leu Thr Glu Ser Asn Arg Ile Ser His
1125 1130 1135
His Lys Ile Leu Ala Ile Val Gly Thr Ala Glu Ser Asn Ser Glu His
1140 1145 1150
Pro Leu Gly Thr Ala Ile Thr Lys Tyr Cys Lys Gln Glu Leu Asp Thr
1155 1160 1165
Glu Thr Leu Gly Thr Cys Ile Asp Phe Gln Val Val Pro Gly Cys Gly
1170 1175 1180
Ile Ser Cys Lys Val Thr Asn Ile Glu Gly Leu Leu His Lys Asn Asn
1185 1190 1195 1200
Trp Asn Ile Glu Asp Asn Asn Ile Lys Asn Ala Ser Leu Val Gln Ile
1205 1210 1215
Asp Ala Ser Asn Glu Gln Ser Ser Thr Ser Ser Ser Met Ile Ile Asp
1220 1225 1230
Ala Gln Ile Ser Asn Ala Leu Asn Ala Gln Gln Tyr Lys Val Leu Ile
1235 1240 1245
Gly Asn Arg Glu Trp Met Ile Arg Asn Gly Leu Val Ile Asn Asn Asp
1250 1255 1260
Val Asn Asp Phe Met Thr Glu His Glu Arg Lys Gly Arg Thr Ala Val
1265 1270 1275 1280
Leu Val Ala Val Asp Asp Glu Leu Cys Gly Leu Ile Ala Ile Ala Asp
1285 1290 1295
Thr Val Lys Pro Glu Ala Glu Leu Ala Ile His Ile Leu Lys Ser Met
1300 1305 1310
Gly Leu Glu Val Val Leu Met Thr Gly Asp Asn Ser Lys Thr Ala Arg
1315 1320 1325
Ser Ile Ala Ser Gln Val Gly Ile Thr Lys Val Phe Ala Glu Val Leu
1330 1335 1340
Pro Ser His Lys Val Ala Lys Val Lys Gln Leu Gln Glu Glu Gly Lys
1345 1350 1355 1360
Arg Val Ala Met Val Gly Asp Gly Ile Asn Asp Ser Pro Ala Leu Ala
1365 1370 1375
Met Ala Asn Val Gly Ile Ala Ile Gly Thr Gly Thr Asp Val Ala Ile
1380 1385 1390
Glu Ala Ala Asp Val Val Leu Ile Arg Asn Asp Leu Leu Asp Val Val
1395 1400 1405
Ala Ser Ile Asp Leu Ser Arg Glu Thr Val Lys Arg Ile Arg Ile Asn
1410 1415 1420
Phe Val Phe Ala Leu Ile Tyr Asn Leu Val Gly Ile Pro Ile Ala Ala
1425 1430 1435 1440
Gly Val Phe Met Pro Ile Gly Leu Val Leu Gln Pro Trp Met Gly Ser
1445 1450 1455
Ala Ala Met Ala Ala Ser Ser Val Ser Val Val Leu Ser Ser Leu Phe
1460 1465 1470
Leu Lys Leu Tyr Arg Lys Pro Thr Tyr Glu Ser Tyr Glu Leu Pro Ala
1475 1480 1485
Arg Ser Gln Ile Gly Gln Lys Ser Pro Ser Glu Ile Ser Val His Val
1490 1495 1500
Gly Ile Asp Asp Thr Ser Arg Asn Ser Pro Lys Leu Gly Leu Leu Asp
1505 1510 1515 1520
Arg Ile Val Asn Tyr Ser Arg Ala Ser Ile Asn Ser Leu Leu Ser Asp
1525 1530 1535
Lys Arg Ser Leu Asn Ser Val Val Thr Ser Glu Pro Asp Lys His Ser
1540 1545 1550
Leu Leu Val Gly Asp Phe Arg Glu Asp Asp Asp Thr Ala Leu
1555 1560 1565
<210>47
<211>171
<212>PRT
<213>人
<400>47
Met Trp Thr Leu Lys Ser Ser Leu Val Leu Leu Leu Cys Leu Thr Cys
1 5 10 15
Ser Tyr Ala Phe Met Phe Ser Ser Leu Arg Gln Lys Thr Ser Glu Pro
20 25 30
Gln Gly Lys Val Gln Tyr Gly Glu His Phe Arg Ile Arg Gln Asn Leu
35 40 45
Pro Glu His Thr Gln Gly Trp Leu Gly Ser Lys Trp Leu Trp Leu Leu
50 55 60
Phe Val Val Val Pro Phe Val Ile Leu Gln Cys Gln Arg Asp Ser Glu
65 70 75 80
Lys Asn Lys Glu Gln Ser Pro Pro Gly Leu Arg Gly Phe Pro Phe Arg
85 90 95
Thr Pro Leu Lys Lys Asn Gln Asn Ala Ser Leu Tyr Lys Asp Cys Val
100 105 110
Phe Asn Thr Leu Asn Glu Leu Glu Val Glu Leu Leu Lys Phe Val Ser
115 120 125
Glu Val Gln Asn Leu Lys Gly Ala Met Ala Thr Gly Ser Gly Ser Asn
130 135 140
Leu Lys Leu Arg Arg Ser Glu Met Pro Ala Asp Pro Tyr His Val Thr
145 150 155 160
Ile Cys Lys Ile Trp Gly Glu Glu Ser Ser Ser
165 170
<210>48
<211>355
<212>PRT
<213>人
<400>48
Met Thr Thr Ser Leu Asp Thr Val Glu Thr Phe Gly Thr Thr Ser Tyr
1 5 10 15
Tyr Asp Asp Val Gly Leu Leu Cys Glu Lys Ala Asp Thr Arg Ala Leu
20 25 30
Met Ala Gln Phe Val Pro Pro Leu Tyr Ser Leu Val Phe Thr Val Gly
35 40 45
Leu Leu Gly Asn Val Val Val Val Met Ile Leu Ile Lys Tyr Arg Arg
50 55 60
Leu Arg Ile Met Thr Asn Ile Tyr Leu Leu Asn Leu Ala Ile Ser Asp
65 70 75 80
Leu Leu Phe Leu Val Thr Leu Pro Phe Trp Ile His Tyr Val Arg Gly
85 90 95
His Asn Trp Val Phe Gly His Gly Met Cys Lys Leu Leu Ser Gly Phe
100 105 110
Tyr His Thr Gly Leu Tyr Ser Glu Ile Phe Phe Ile Ile Leu Leu Thr
115 120 125
Ile Asp Arg Tyr Leu Ala Ile Val His Ala Val Phe Ala Leu Arg Ala
130 135 140
Arg Thr Val Thr Phe Gly Val Ile Thr Ser Ile Val Thr Trp Gly Leu
145 150 155 160
Ala Val Leu Ala Ala Leu Pro Glu Phe Ile Phe Tyr Glu Thr Glu Glu
165 170 175
Leu Phe Glu Glu Thr Leu Cys Ser Ala Leu Tyr Pro Glu Asp Thr Val
180 185 190
Tyr Ser Trp Arg His Phe His Thr Leu Arg Met Thr Ile Phe Cys Leu
195 200 205
Val Leu Pro Leu Leu Val Met Ala Ile Cys Tyr Thr Gly Ile Ile Lys
210 215 220
Thr Leu Leu Arg Cys Pro Ser Lys Lys Lys Tyr Lys Ala Ile Arg Leu
225 230 235 240
Ile Phe Val Ile Met Ala Val Phe Phe Ile Phe Trp Thr Pro Tyr Asn
245 250 255
Val Ala Ile Leu Leu Ser Ser Tyr Gln Ser Ile Leu Phe Gly Asn Asp
260 265 270
Cys Glu Arg Ser Lys His Leu Asp Leu Val Met Leu Val Thr Glu Val
275 280 285
Ile Ala Tyr Ser His Cys Cys Met Asn Pro Val Ile Tyr Ala Phe Val
290 295 300
Gly Glu Arg Phe Arg Lys Tyr Leu Arg His Phe Phe His Arg His Leu
305 310 315 320
Leu Met His Leu Gly Arg Tyr Ile Pro Phe Leu Pro Ser Glu Lys Leu
325 330 335
Glu Arg Thr Ser Ser Val Ser Pro Ser Thr Ala Glu Pro Glu Leu Ser
340 345 350
Ile Val Phe
355
<210>49
<211>399
<212>PRT
<213>人
<400>49
Met Ala Gln Arg Gln Pro His Ser Pro Asn Gln Thr Leu Ile Ser Ile
1 5 10 15
Thr Asn Asp Thr Glu Ser Ser Ser Ser Val Val Ser Asn Asp Asn Thr
20 25 30
Asn Lys Gly Trp Ser Gly Asp Asn Ser Pro Gly Ile Glu Ala Leu Cys
35 40 45
Ala Ile Tyr Ile Thr Tyr Ala Val Ile Ile Ser Val Gly Ile Leu Gly
50 55 60
Asn Ala Ile Leu Ile Lys Val Phe Phe Lys Thr Lys Ser Met Gln Thr
65 70 75 80
Val Pro Asn Ile Phe Ile Thr Ser Leu Ala Phe Gly Asp Leu Leu Leu
85 90 95
Leu Leu Thr Cys Val Pro Val Asp Ala Thr His Tyr Leu Ala Glu Gly
100 105 110
Trp Leu Phe Gly Arg Ile Gly Cys Lys Val Leu Ser Phe Ile Arg Leu
115 120 125
Thr Ser Val Gly Val Ser Val Phe Thr Leu Thr Ile Leu Ser Ala Asp
130 135 140
Arg Tyr Lys Ala Val Val Lys Pro Leu Glu Arg Gln Pro Ser Asn Ala
145 150 155 160
Ile Leu Lys Thr Cys Val Lys Ala Gly Cys Val Trp Ile Val Ser Met
165 170 175
Ile Phe Ala Leu Pro Glu Ala Ile Phe Ser Asn Val Tyr Thr Phe Arg
180 185 190
Asp Pro Asn Lys Asn Met Thr Phe Glu Ser Cys Thr Ser Tyr Pro Val
195 200 205
Ser Lys Lys Leu Leu Gln Glu Ile His Ser Leu Leu Cys Phe Leu Val
210 215 220
Phe Tyr Ile Ile Pro Leu Ser Ile Ile Ser Val Tyr Tyr Ser Leu Ile
225 230 235 240
Ala Arg Thr Leu Tyr Lys Ser Thr Leu Asn Ile Pro Thr Glu Glu Gln
245 250 255
Ser His Ala Arg Lys Gln Ile Glu Ser Arg Lys Arg Ile Ala Arg Thr
260 265 270
Val Leu Val Leu Val Ala Leu Phe Ala Leu Cys Trp Leu Pro Asn His
275 280 285
Leu Leu Tyr Leu Tyr His Ser Phe Thr Ser Gln Thr Tyr Val Asp Pro
290 295 300
Ser Ala Met His Phe Ile Phe Thr Ile Phe Ser Arg Val Leu Ala Phe
305 310 315 320
Ser Asn Ser Cys Val Asn Pro Phe Ala Leu Tyr Trp Leu Ser Lys Ser
325 330 335
Phe Gln Lys His Phe Lys Ala Gln Leu Phe Cys Cys Lys Ala Glu Arg
340 345 350
Pro Glu Pro Pro Val Ala Asp Thr Ser Leu Thr Thr Leu Ala Val Met
355 360 365
Gly Thr Val Pro Gly Thr Gly Ser Ile Gln Met Ser Glu Ile Ser Val
370 375 380
Thr Ser Phe Thr Gly Cys Ser Val Lys Gln Ala Glu Asp Arg Phe
385 390 395
<210>50
<211>171
<212>PRT
<213>人
<400>50
Met Trp Thr Leu Lys Ser Ser Leu Val Leu Leu Leu Cys Leu Thr Cys
1 5 10 15
Ser Tyr Ala Phe Met Phe Ser Ser Leu Arg Gln Lys Thr Ser Glu Pro
20 25 30
Gln Gly Lys Val Gln Tyr Gly Glu His Phe Arg Ile Arg Gln Asn Leu
35 40 45
Pro Glu His Thr Gln Gly Trp Leu Gly Ser Lys Trp Leu Trp Leu Leu
50 55 60
Phe Val Val Val Pro Phe Val Ile Leu Gln Cys Gln Arg Asp Ser Glu
65 70 75 80
Lys Asn Lys Glu Gln Ser Pro Pro Gly Leu Arg Gly Gly Gln Leu His
85 90 95
Ser Pro Leu Lys Lys Lys Arg Asn Ala Ser Pro Asn Lys Asp Cys Ala
100 105 110
Phe Asn Thr Leu Met Glu Leu Glu Val Glu Leu Met Lys Phe Val Ser
115 120 125
Lys Val Arg Asn Leu Lys Arg Ala Met Ala Thr Gly Ser Gly Ser Asn
130 135 140
Leu Arg Leu Arg Lys Ser Glu Met Pro Ala Asp Pro Tyr His Val Thr
145 150 155 160
Ile Cys Glu Ile Trp Gly Glu Glu Ser Ser Ser
165 170
<210>51
<211>217
<212>PRT
<213>人
<400>51
Met Ala Glu Phe Asp Thr Ile Ser Glu Leu Glu Glu Glu Glu Glu Glu
1 5 10 15
Glu Ala Ala Thr Ser Ser Ser Ser Pro Ser Ser Ser Ser Ser Val Ser
20 25 30
Gly Pro Asp Asp Asp Glu Glu Asp Glu Glu Glu Glu Glu Glu Glu Glu
35 40 45
Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Ala Pro Pro
50 55 60
Pro Pro Arg Val Val Ser Glu Glu His Leu Arg Arg Tyr Ala Pro Asp
65 70 75 80
Pro Val Leu Val Arg Gly Ala Gly His Ile Thr Val Phe Gly Leu Ser
85 90 95
Asn Lys Phe Asp Thr Glu Phe Pro Ser Val Leu Thr Gly Lys Val Ala
100 105 110
Pro Glu Glu Phe Lys Thr Ser Ile Gly Arg Val Asn Ala Cys Leu Lys
115 120 125
Lys Ala Leu Pro Val Asn Val Lys Trp Leu Leu Cys Gly Cys Leu Cys
130 135 140
Cys Cys Cys Thr Leu Gly Cys Ser Leu Trp Pro Val Ile Cys Leu Asn
145 150 155 160
Lys Arg Thr Arg Arg Ser Ile Gln Lys Leu Ile Glu Trp Glu Asn Asn
165 170 175
Arg Leu Tyr His Lys Leu Ala Leu His Trp Lys Leu Thr Lys Arg Lys
180 185 190
Cys Glu Thr Ser Asn Met Met Glu Tyr Val Ile Leu Ile Glu Phe Leu
195 200 205
Pro Lys Tyr Pro Ile Phe Arg Pro Asp
210 215
<210>52
<211>217
<212>PRT
<213>人
<400>52
Met Ala Glu Phe Asp Thr Ile Ser Glu Leu Glu Glu Glu Glu Glu Glu
1 5 10 15
Glu Ala Ala Thr Ser Ser Ser Ser Pro Ser Ser Ser Ser Ser Val Ser
20 25 30
Gly Pro Asp Asp Asp Glu Glu Asp Glu Glu Glu Glu Glu Glu Glu Glu
35 40 45
Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Ala Pro Pro
50 55 60
Pro Pro Arg Val Val Ser Glu Glu His Leu Arg Arg Tyr Ala Pro Asp
65 70 75 80
Pro Val Leu Val Arg Gly Ala Gly His Ile Thr Val Phe Gly Leu Ser
85 90 95
Asn Lys Phe Asp Thr Glu Phe Pro Ser Val Leu Thr Gly Lys Val Ala
100 105 110
Pro Glu Glu Phe Lys Thr Ser Ile Gly Arg Val Asn Ala Cys Leu Lys
115 120 125
Lys Ala Leu Pro Val Asn Val Lys Trp Leu Leu Cys Gly Cys Leu Cys
130 135 140
Cys Cys Cys Thr Leu Gly Cys Ser Leu Trp Pro Val Ile Cys Leu Asn
145 150 155 160
Lys Arg Thr Arg Arg Ser Ile Gln Lys Leu Ile Glu Trp Glu Asn Asn
165 170 175
Arg Leu Tyr His Lys Leu Ala Leu His Trp Lys Leu Thr Lys Arg Lys
180 185 190
Cys Glu Thr Ser Asn Met Met Glu Tyr Val Ile Leu Ile Glu Phe Leu
195 200 205
Pro Lys Tyr Pro Ile Phe Arg Pro Asp
210 215
<210>53
<211>1422
<212>PRT
<213>人
<400>53
Met Asp Pro Ser Met Gly Val Asn Ser Val Thr Ile Ser Val Glu Gly
1 5 10 15
Met Thr Cys Asn Ser Cys Val Trp Thr Ile Glu Gln Gln Ile Gly Lys
20 25 30
Val Asn Gly Val His His Ile Lys Val Ser Leu Glu Glu Lys Asn Ala
35 40 45
Thr Ile Ile Tyr Asp Pro Lys Leu Gln Thr Pro Lys Thr Leu Gln Glu
50 55 60
Ala Ile Asp Asp Met Gly Phe Asp Ala Val Ile His Asn Pro Asp Pro
65 70 75 80
Leu Pro Val Leu Thr Asp Thr Leu Phe Leu Thr Val Thr Ala Ser Leu
85 90 95
Thr Leu Pro Trp Asp His Ile Gln Ser Thr Leu Leu Lys Thr Lys Gly
100 105 110
Val Thr Asp Ile Lys Ile Tyr Pro Gln Lys Arg Thr Val Ala Val Thr
115 120 125
Ile Ile Pro Ser Ile Val Asn Ala Asn Gln Ile Lys Glu Leu Val Pro
130 135 140
Glu Leu Ser Leu Asp Thr Gly Thr Leu Glu Lys Lys Ser Gly Ala Cys
145 150 155 160
Glu Asp His Ser Met Ala Gln Ala Gly Glu Val Val Leu Lys Met Lys
165 170 175
Val Glu Gly Met Thr Cys His Ser Cys Thr Ser Thr Ile Glu Gly Lys
180 185 190
Ile Gly Lys Leu Gln Gly Val Gln Arg Ile Lys Val Ser Leu Asp Asn
195 200 205
Gln Glu Ala Thr Ile Val Tyr Gln Pro His Leu Ile Ser Val Glu Glu
210 215 220
Met Lys Lys Gln Ile Glu Ala Met Gly Phe Pro Ala Phe Val Lys Lys
225 230 235 240
Gln Pro Lys Tyr Leu Lys Leu Gly Ala Ile Asp Val Glu Arg Leu Lys
245 250 255
Asn Thr Pro Val Lys Ser Ser Glu Gly Ser Gln Gln Arg Ser Pro Ser
260 265 270
Tyr Thr Asn Asp Ser Thr Ala Thr Phe Ile Ile Asp Gly Met His Cys
275 280 285
Lys Ser Cys Val Ser Asn Ile Glu Ser Thr Leu Ser Ala Leu Gln Tyr
290 295 300
Val Ser Ser Ile Val Val Ser Leu Glu Asn Arg Ser Ala Ile Val Lys
305 310 315 320
Tyr Asn Ala Ser Ser Val Thr Pro Glu Ser Leu Arg Lys Ala Ile Glu
325 330 335
Ala Val Ser Pro Gly Leu Tyr Arg Val Ser Ile Thr Ser Glu Val Glu
340 345 350
Ser Thr Ser Asn Ser Pro Ser Ser Ser Ser Leu Gln Lys Ile Pro Leu
355 360 365
Asn Val Val Ser Gln Pro Leu Thr Gln Glu Thr Val Ile Asn Ile Asp
370 375 380
Gly Met Thr Cys Asn Ser Cys Val Gln Ser Ile Glu Gly Val Ile Ser
385 390 395 400
Lys Lys Pro Gly Val Lys Ser Ile Arg Val Ser Leu Ala Asn Ser Asn
405 410 415
Gly Thr Val Glu Tyr Asp Pro Leu Leu Thr Ser Pro Glu Thr Leu Arg
420 425 430
Gly Ala Ile Glu Asp Met Gly Phe Asp Ala Thr Leu Ser Asp Thr Asn
435 440 445
Glu Pro Leu Val Val Ile Ala Gln Pro Ser Ser Glu Met Pro Leu Leu
450 455 460
Thr Ser Thr Asn Glu Phe Tyr Thr Lys Gly Met Thr Pro Val Gln Asp
465 470 475 480
Lys Glu Glu Gly Lys Asn Ser Ser Lys Cys Tyr Ile Gln Val Thr Gly
485 490 495
Met Thr Cys Ala Ser Cys Val Ala Asn Ile Glu Arg Asn Leu Arg Arg
500 505 510
Glu Glu Gly Ile Tyr Ser Ile Leu Val Ala Leu Met Ala Gly Lys Ala
515 520 525
Glu Val Arg Tyr Asn Pro Ala Val Ile Gln Pro Pro Met Ile Ala Glu
530 535 540
Phe Ile Arg Glu Leu Gly Phe Gly Ala Thr Val Ile Glu Asn Ala Asp
545 550 555 560
Glu Gly Asp Gly Val Leu Glu Leu Val Val Arg Gly Met Thr Cys Ala
565 570 575
Ser Cys Val His Lys Ile Glu Ser Ser Leu Thr Lys His Arg Gly Ile
580 585 590
Leu Tyr Cys Ser Val Ala Leu Ala Thr Asn Lys Ala His Ile Lys Tyr
595 600 605
Asp Pro Glu Ile Ile Gly Pro Arg Asp Ile Ile His Thr Ile Glu Ser
610 615 620
Leu Gly Phe Glu Ala Ser Leu Val Lys Lys Asp Arg Ser Ala Ser His
625 630 635 640
Leu Asp His Lys Arg Glu Ile Arg Gln Trp Arg Arg Ser Phe Leu Val
645 650 655
Ser Leu Phe Phe Cys Ile Pro Val Met Gly Leu Met Ile Tyr Met Met
660 665 670
Val Met Asp His His Phe Ala Thr Leu His His Asn Gln Asn Met Ser
675 680 685
Lys Glu Glu Met Ile Asn Leu His Ser Ser Met Phe Leu Glu Arg Gln
690 695 700
Ile Leu Pro Gly Leu Ser Val Met Asn Leu Leu Ser Phe Leu Leu Cys
705 710 715 720
Val Pro Leu Glu Gly Lys Thr Ser Glu Ala Leu Ala Lys Leu Ile Ser
725 730 735
Leu Gln Ala Thr Glu Ala Thr Ile Val Thr Leu Asp Ser Asp Asn Ile
740 745 750
Leu Leu Ser Glu Glu Gln Val Asp Val Glu Leu Val Gln Arg Gly Asp
755 760 765
Ile Ile Lys Val Val Pro Gly Gly Lys Phe Pro Val Asp Gly Arg Val
770 775 780
Ile Glu Gly His Ser Met Val Asp Glu Ser Leu Ile Thr Gly Glu Ala
785 790 795 800
Met Pro Val Ala Lys Lys Pro Gly Ser Thr Val Ile Ala Gly Ser Ile
805 810 815
Asn Gln Asn Gly Ser Leu Leu Ile Cys Ala Thr His Val Gly Ala Asp
820 825 830
Thr Thr Leu Ser Gln Ile Val Lys Leu Val Glu Glu Ala Gln Thr Ser
835 840 845
Lys Ala Pro Ile Gln Gln Phe Ala Asp Lys Leu Ser Gly Tyr Phe Val
850 855 860
Pro Phe Ile Val Phe Val Ser Ile Ala Thr Leu Leu Val Trp Ile Val
865 870 875 880
Ile Gly Phe Leu Asn Phe Glu Ile Val Glu Thr Tyr Phe Pro Gly Tyr
885 890 895
Asn Arg Ser Ile Ser Arg Thr Glu Thr Ile Ile Arg Phe Ala Phe Gln
900 905 910
Ala Ser Ile Thr Val Leu Cys Ile Ala Cys Pro Cys Ser Leu Gly Leu
915 920 925
Ala Thr Pro Thr Ala Val Met Val Gly Thr Gly Val Gly Ala Gln Asn
930 935 940
Gly Ile Leu Ile Lys Gly Gly Glu Pro Leu Glu Met Ala His Lys Val
945 950 955 960
Lys Val Val Val Phe Asp Lys Thr Gly Thr Ile Thr His Gly Thr Pro
965 970 975
Val Val Asn Gln Val Lys Val Leu Thr Glu Ser Asn Arg Ile Ser His
980 985 990
His Lys Ile Leu Ala Ile Val Gly Thr Ala Glu Ser Asn Ser Glu His
995 1000 1005
Pro Leu Gly Thr Ala Ile Thr Lys Tyr Cys Lys Gln Glu Leu Asp Thr
1010 1015 1020
Glu Thr Leu Gly Thr Cys Ile Asp Phe Gln Val Val Pro Gly Cys Gly
1025 1030 1035 1040
Ile Ser Cys Lys Val Thr Asn Ile Glu Gly Leu Leu His Lys Asn Asn
1045 1050 1055
Trp Asn Ile Glu Asp Asn Asn Ile Lys Asn Ala Ser Leu Val Gln Ile
1060 1065 1070
Asp Ala Ser Asn Glu Gln Ser Ser Thr Ser Ser Ser Met Ile Ile Asp
1075 1080 1085
Ala Gln Ile Ser Asn Ala Leu Asn Ala Gln Gln Tyr Lys Val Leu Ile
1090 1095 1100
Gly Asn Arg Glu Trp Met Ile Arg Asn Gly Leu Val Ile Asn Asn Asp
1105 1110 1115 1120
Val Asn Asp Phe Met Thr Glu His Glu Arg Lys Gly Arg Thr Ala Val
1125 1130 1135
Leu Val Ala Val Asp Asp Glu Leu Cys Gly Leu Ile Ala Ile Ala Asp
1140 1145 1150
Thr Val Lys Pro Glu Ala Glu Leu Ala Ile His Ile Leu Lys Ser Met
1155 1160 1165
Gly Leu Glu Val Val Leu Met Thr Gly Asp Asn Ser Lys Thr Ala Arg
1170 1175 1180
Ser Ile Ala Ser Gln Val Gly Ile Thr Lys Val Phe Ala Glu Val Leu
1185 1190 1195 1200
Pro Ser His Lys Val Ala Lys Val Lys Gln Leu Gln Glu Glu Gly Lys
1205 1210 1215
Arg Val Ala Met Val Gly Asp Gly Ile Asn Asp Ser Pro Ala Leu Ala
1220 1225 1230
Met Ala Asn Val Gly Ile Ala Ile Gly Thr Gly Thr Asp Val Ala Ile
1235 1240 1245
Glu Ala Ala Asp Val Val Leu Ile Arg Asn Asp Leu Leu Asp Val Val
1250 1255 1260
Ala Ser Ile Asp Leu Ser Arg Glu Thr Val Lys Arg Ile Arg Ile Asn
1265 1270 1275 1280
Phe Val Phe Ala Leu Ile Tyr Asn Leu Val Gly Ile Pro Ile Ala Ala
1285 1290 1295
Gly Val Phe Met Pro Ile Gly Leu Val Leu Gln Pro Trp Met Gly Ser
1300 1305 1310
Ala Ala Met Ala Ala Ser Ser Val Ser Val Val Leu Ser Ser Leu Phe
1315 1320 1325
Leu Lys Leu Tyr Arg Lys Pro Thr Tyr Glu Ser Tyr Glu Leu Pro Ala
1330 1335 1340
Arg Ser Gln Ile Gly Gln Lys Ser Pro Ser Glu Ile Ser Val His Val
1345 1350 1355 1360
Gly lle Asp Asp Thr Ser Arg Asn Ser Pro Lys Leu Gly Leu Leu Asp
1365 1370 1375
Arg Ile Val Asn Tyr Ser Arg Ala Ser Ile Asn Ser Leu Leu Ser Asp
1380 1385 1390
Lys Arg Ser Leu Asn Ser Val Val Thr Ser Glu Pro Asp Lys His Ser
1395 1400 1405
Leu Leu Val Gly Asp Phe Arg Glu Asp Asp Asp Thr Ala Leu
1410 1415 1420
<210>54
<211>503
<212>PRT
<213>人
<400>54
Met Asp Pro Ser Met Gly Val Asn Ser Val Thr Ile Ser Val Glu Gly
1 5 10 15
Met Thr Cys Asn Ser Cys Val Trp Thr Ile Glu Gln Gln Ile Gly Lys
20 25 30
Val Asn Gly Val His His Ile Lys Val Lys Val Val Val Phe Asp Lys
35 40 45
Thr Gly Thr Ile Thr His Gly Thr Pro Val Val Asn Gln Val Lys Val
50 55 60
Leu Thr Glu Ser Asn Arg Ile Ser His His Lys Ile Leu Ala Ile Val
65 70 75 80
Gly Thr Ala Glu Ser Asn Ser Glu His Pro Leu Gly Thr Ala Ile Thr
85 90 95
Lys Tyr Cys Lys Gln Glu Leu Asp Thr Glu Thr Leu Gly Thr Cys Ile
100 105 110
Asp Phe Gln Val Val Pro Gly Cys Gly Ile Ser Cys Lys Val Thr Asn
115 120 125
Ile Glu Gly Leu Leu His Lys Asn Asn Trp Asn Ile Glu Asp Asn Asn
130 135 140
Ile Lys Asn Ala Ser Leu Val Gln Ile Asp Ala Ser Asn Glu Gln Ser
145 150 155 160
Ser Thr Ser Ser Ser Met Ile Ile Asp Ala Gln Ile Ser Asn Ala Leu
165 170 175
Asn Ala Gln Gln Tyr Lys Val Leu Ile Gly Asn Arg Glu Trp Met Ile
180 185 190
Arg Asn Gly Leu Val Ile Asn Asn Asp Val Asn Asp Phe Met Thr Glu
195 200 205
His Glu Arg Lys Gly Arg Thr Ala Val Leu Val Ala Val Asp Asp Glu
210 215 220
Leu Cys Gly Leu Ile Ala Ile Ala Asp Thr Val Lys Pro Glu Ala Glu
225 230 235 240
Leu Ala Ile His Ile Leu Lys Ser Met Gly Leu Glu Val Val Leu Met
245 250 255
Thr Gly Asp Asn Ser Lys Thr Ala Arg Ser Ile Ala Ser Gln Val Gly
260 265 270
Ile Thr Lys Val Phe Ala Glu Val Leu Pro Ser His Lys Val Ala Lys
275 280 285
Val Lys Gln Leu Gln Glu Glu Gly Lys Arg Val Ala Met Val Gly Asp
290 295 300
Gly Ile Asn Asp Ser Pro Ala Leu Ala Met Ala Asn Val Gly Ile Ala
305 310 315 320
Ile Gly Thr Gly Thr Asp Val Ala Ile Glu Ala Ala Asp Val Val Leu
325 330 335
Ile Arg Asn Asp Leu Leu Asp Val Val Ala Ser Ile Asp Leu Ser Arg
340 345 350
Glu Thr Val Lys Arg Ile Arg Ile Asn Phe Val Phe Ala Leu Ile Tyr
355 360 365
Asn Leu Val Gly Ile Pro Ile Ala Ala Gly Val Phe Met Pro Ile Gly
370 375 380
Leu Val Leu Gln Pro Trp Met Gly Ser Ala Ala Met Ala Ala Ser Ser
385 390 395 400
Val Ser Val Val Leu Ser Ser Leu Phe Leu Lys Leu Tyr Arg Lys Pro
405 410 415
Thr Tyr Glu Ser Tyr Glu Leu Pro Ala Arg Ser Gln Ile Gly Gln Lys
420 425 430
Ser Pro Ser Glu Ile Ser Val His Val Gly Ile Asp Asp Thr Ser Arg
435 440 445
Asn Ser Pro Lys Leu Gly Leu Leu Asp Arg Ile Val Asn Tyr Ser Arg
450 455 460
Ala Ser Ile Asn Ser Leu Leu Ser Asp Lys Arg Ser Leu Asn Ser Val
465 470 475 480
Val Thr Ser Glu Pro Asp Lys His Ser Leu Leu Val Gly Asp Phe Arg
485 490 495
Glu Asp Asp Asp Thr Ala Leu
500
<210>55
<211>350
<212>PRT
<213>人
<400>55
Met Ala Val Phe Val Val Leu Leu Ala Leu Val Ala Gly Val Leu Gly
1 5 10 15
Asn Glu Phe Ser Ile Leu Lys Ser Pro Gly Ser Val Val Phe Arg Asn
20 25 30
Gly Asn Trp Pro Ile Pro Gly Glu Arg Ile Pro Asp Val Ala Ala Leu
35 40 45
Ser Met Gly Phe Ser Val Lys Glu Asp Leu Ser Trp Pro Gly Leu Ala
50 55 60
Val Gly Asn Leu Phe His Arg Pro Arg Ala Thr Val Met Val Met Val
65 70 75 80
Lys Gly Val Asn Lys Leu Ala Leu Pro Pro Gly Ser Val Ile Ser Tyr
85 90 95
Pro Leu Glu Asn Ala Val Pro Phe Ser Leu Asp Ser Val Ala Asn Ser
100 105 110
Ile His Ser Leu Phe Ser Glu Glu Thr Pro Val Val Leu Gln Leu Ala
115 120 125
Pro Ser Glu Glu Arg Val Tyr Met Val Gly Lys Ala Asn Ser Val Phe
130 135 140
Glu Asp Leu Ser Val Thr Leu Arg Gln Leu Arg Asn Arg Leu Phe Gln
145 150 155 160
Glu Asn Ser Val Leu Ser Ser Leu Pro Leu Asn Ser Leu Ser Arg Asn
165 170 175
Asn Glu Val Asp Leu Leu Phe Leu Ser Glu Leu Gln Val Leu His Asp
180 185 190
Ile Ser Ser Leu Leu Ser Arg His Lys His Leu Ala Lys Asp His Ser
195 200 205
Pro Asp Leu Tyr Ser Leu Glu Leu Ala Gly Leu Asp Glu Ile Gly Lys
210 215 220
Arg Tyr Gly Glu Asp Ser Glu Gln Phe Arg Asp Ala Ser Lys Ile Leu
225 230 235 240
Val Asp Ala Leu Gln Lys Phe Ala Asp Asp Met Tyr Ser Leu Tyr Gly
245 250 255
Gly Asn Ala Val Val Glu Leu Val Thr Val Lys Ser Phe Asp Thr Ser
260 265 270
Leu Ile Arg Lys Thr Arg Thr Ile Leu Glu Ala Lys Gln Ala Lys Asn
275 280 285
Pro Ala Ser Pro Tyr Asn Leu Ala Tyr Lys Tyr Asn Phe Glu Tyr Ser
290 295 300
Val Val Phe Asn Met Val Leu Trp Ile Met Ile Ala Leu Ala Leu Ala
305 310 315 320
Val Ile Ile Thr Ser Tyr Asn Ile Trp Asn Met Asp Pro Gly Tyr Asp
325 330 335
Ser Ile Ile Tyr Arg Met Thr Asn Gln Lys Ile Arg Met Asp
340 345 350
<210>56
<211>444
<212>PRT
<213>人
<400>56
Met Lys Phe Pro Ala Ser Val Leu Ala Ser Val Phe Leu Phe Val Ala
1 5 10 15
Glu Thr Thr Ala Ala Leu Ser Leu Ser Ser Thr Tyr Arg Ser Gly Gly
20 25 30
Asp Arg Met Trp Gln Ala Leu Thr Leu Leu Phe Ser Leu Leu Pro Cys
35 40 45
Ala Leu Val Gln Leu Thr Leu Leu Phe Val His Arg Asp Leu Ser Arg
50 55 60
Asp Arg Pro Leu Val Leu Leu Leu His Leu Leu Gln Leu Gly Pro Leu
65 70 75 80
Phe Arg Cys Phe Glu Val Phe Cys Ile Tyr Phe Gln Ser Gly Asn Asn
85 90 95
Glu Glu Pro Tyr Val Ser Ile Thr Lys Lys Arg Gln Met Pro Lys Asn
100 105 110
Gly Leu Ser Glu Glu Ile Glu Lys Glu Val Gly Gln Ala Glu Gly Lys
115 120 125
Leu Ile Thr His Arg Ser Ala Phe Ser Arg Ala Ser Val Ile Gln Ala
130 135 140
Phe Leu Gly Ser Ala Pro Gln Leu Thr Leu Gln Leu Tyr Ile Ser Val
145 150 155 160
Met Gln Gln Asp Val Thr Val Gly Arg Ser Leu Leu Met Thr Ile Ser
165 170 175
Leu Leu Ser Ile Val Tyr Gly Ala Leu Arg Cys Asn Ile Leu Ala Ile
180 185 190
Lys Ile Lys Tyr Asp Glu Tyr Glu Val Lys Val Lys Pro Leu Ala Tyr
195 200 205
Val Cys Ile Phe Leu Trp Arg Ser Phe Glu Ile Ala Thr Arg Val Val
210 215 220
Val Leu Val Leu Phe Thr Ser Val Leu Lys Thr Trp Val Val Val Ile
225 230 235 240
Ile Leu Ile Asn Phe Phe Ser Phe Phe Leu Tyr Pro Trp Ile Leu Phe
245 250 255
Trp Cys Ser Gly Ser Pro Phe Pro Glu Asn Ile Glu Lys Ala Leu Ser
260 265 270
Arg Val Gly Thr Thr Ile Val Leu Cys Phe Leu Thr Leu Leu Tyr Thr
275 280 285
Gly Ile Asn Met Phe Cys Trp Ser Ala Val Gln Leu Lys Ile Asp Ser
290 295 300
Pro Asp Leu Ile Ser Lys Ser His Asn Trp Tyr Gln Leu Leu Val Tyr
305 310 315 320
Tyr Met Ile Arg Phe Ile Glu Asn Ala Ile Leu Leu Leu Leu Trp Tyr
325 330 335
Leu Phe Lys Thr Asp Ile Tyr Met Tyr Val Cys Ala Pro Leu Leu Val
340 345 350
Leu Gln Leu Leu Ile Gly Tyr Cys Thr Ala Ile Leu Phe Met Leu Val
355 360 365
Phe Tyr Gln Phe Phe His Pro Cys Lys Lys Leu Phe Ser Ser Ser Val
370 375 380
Ser Glu Gly Phe Gln Arg Trp Leu Arg Cys Phe Cys Trp Ala Cys Arg
385 390 395 400
Gln Gln Lys Pro Cys Glu Pro Ile Gly Lys Glu Asp Leu Gln Ser Ser
405 410 415
Arg Asp Arg Asp Glu Thr Pro Ser Ser Ser Lys Thr Ser Pro Glu Pro
420 425 430
Gly Gln Phe Leu Asn Ala Glu Asp Leu Cys Ser Ala
435 440
<210>57
<211>214
<212>PRT
<213>人
<400>57
Ala Thr Met Val Trp Phe Cys Asn Ser Ala Asp Cys Gln Phe Ser Val
1 5 10 15
Phe Ala Leu Thr Thr Ile Gly Trp Ile Leu Ser Ser Thr Ser Thr Gly
20 25 30
Leu Val Glu Trp Arg Ile Trp Tyr Met Lys Asp Thr Ser Leu Tyr Pro
35 40 45
Pro Gly Ile Ala Cys Val Gly Ile Phe Arg Val Cys Ile Tyr Arg Arg
50 55 60
Arg Thr Asn Ser Thr Thr Thr Lys Phe Cys Tyr Arg Tyr Ser Tyr Gln
65 70 75 80
Asp Thr Phe Leu Pro Phe Glu Ile Ser Met Ala Gln Arg Phe Leu Leu
85 90 95
Thr Ala Ser Ile Phe Gly Phe Phe Gly Arg Ala Phe Asn Met Phe Ala
100 105 110
Leu Arg Asn Met Ser Met Arg Met Phe Glu Glu Asp Thr Tyr Asn Ser
115 120 125
Phe Val Val Ser Gly Ile Leu Asn Ile Ala Ala Gly Val Phe Asn Leu
130 135 140
Ile Ala Val Leu Gln Asn Tyr Asp Ala Val Ile Asn Ser Gln Gly Ile
145 150 155 160
Thr Phe Leu Pro Ser Leu Gln Met Pro Phe Lys Pro Asp Val Gln Glu
165 170 175
Val Gly Thr Ala Ile Gln Val Ala Gly Ile Gly Val Leu Pro Met Leu
180 185 190
Leu Thr Gly Met Phe Ser Leu Phe Tyr Lys Cys Pro Pro Met Leu Tyr
195 200 205
Gln Ile Phe Pro Thr Thr
210
<210>58
<211>195
<212>PRT
<213>人
<400>58
Met Ala Ala Glu Asp Val Val Ala Thr Gly Ala Asp Pro Ser Asp Leu
1 5 10 15
Glu Ser Gly Gly Leu Leu His Glu Ile Phe Thr Ser Pro Leu Asn Leu
20 25 30
Leu Leu Leu Gly Leu Cys Ile Phe Leu Leu Tyr Lys Ile Val Arg Gly
35 40 45
Asp Gln Pro Ala Ala Ser Gly Asp Ser Asp Asp Asp Glu Pro Pro Pro
50 55 60
Leu Pro Arg Leu Lys Arg Arg Asp Phe Thr Pro Ala Glu Leu Arg Arg
65 70 75 80
Phe Asp Gly Val Gln Asp Pro Arg Ile Leu Met Ala Ile Asn Gly Lys
85 90 95
Val Phe Asp Val Thr Lys Gly Arg Lys Phe Tyr Gly Pro Glu Gly Pro
100 105 110
Tyr Gly Val Phe Ala Gly Arg Asp Ala Ser Arg Gly Leu Ala Thr Phe
115 120 125
Cys Leu Asp Lys Glu Ala Leu Lys Asp Glu Tyr Asp Asp Leu Ser Asp
130 135 140
Leu Thr Ala Ala Gln Gln Glu Thr Leu Ser Asp Trp Glu Ser Gln Phe
145 150 155 160
Thr Phe Lys Tyr His His Val Gly Lys Leu Leu Lys Glu Gly Glu Glu
165 170 175
Pro Thr Val Tyr Ser Asp Glu Glu Glu Pro Lys Asp Glu Ser Ala Arg
180 185 190
Lys Asn Asp
195
<210>59
<211>89
<212>PRT
<213>人
<400>59
Gln Glu Cys Asn Glu Glu Ile Lys Met Asp Pro Ser Met Gly Val Asn
1 5 10 15
Ser Val Thr Ile Ser Val Glu Gly Met Thr Cys Asn Ser Cys Val Trp
20 25 30
Thr Ile Glu Gln Gln Ile Gly Lys Val Asn Gly Val His His Ile Lys
35 40 45
Val Ile Ser Leu Glu Asn Arg Ser Ala Ile Val Asn Phe Tyr Ala His
50 55 60
Trp Phe Gly Phe Ala Ala Leu Asp Gly Ile Cys Ser Asn Gly Cys Phe
65 70 75 80
Ile Cys Phe Cys Ser Thr Phe Phe Ser
85
<210>60
<211>387
<212>PRT
<213>人
<400>60
Met Arg Glu Pro Leu Glu Ala Phe Lys Leu Ala Asp Leu Asp Phe Arg
1 5 10 15
Lys Ser Ser Leu Ala Ser Gly Trp Arg Met Ala Ser Gly Ala Phe Thr
20 25 30
Met Asp Gln Phe Pro Glu Ser Val Thr Glu Asn Phe Glu Tyr Asp Asp
35 40 45
Leu Ala Glu Ala Cys Tyr Ile Gly Asp Ile Val Val Phe Gly Thr Val
50 55 60
Phe Leu Ser Ile Phe Tyr Ser Val Ile Phe Ala Ile Gly Leu Val Gly
65 70 75 80
Asn Leu Leu Val Val Phe Ala Leu Thr Asn Ser Lys Lys Pro Lys Ser
85 90 95
Val Thr Asp Ile Tyr Leu Leu Asn Leu Ala Leu Ser Asp Leu Leu Phe
100 105 110
Val Ala Thr Leu Pro Phe Trp Thr His Tyr Leu Ile Asn Glu Lys Gly
115 120 125
Leu His Asn Ala Met Cys Lys Phe Thr Thr Ala Phe Phe Phe Ile Gly
130 135 140
Phe Phe Gly Ser Ile Phe Phe Ile Thr Val Ile Ser Ile Asp Arg Tyr
145 150 155 160
Leu Ala Ile Val Leu Ala Ala Asn Ser Met Asn Asn Arg Thr Val Gln
165 170 175
His Gly Val Thr Ile Ser Leu Gly Val Trp Ala Ala Ala Ile Leu Val
180 185 190
Ala Ala Pro Gln Phe Met Phe Thr Lys Gln Lys Glu Asn Glu Cys Leu
195 200 205
Gly Asp Tyr Pro Glu Val Leu Gln Glu Ile Trp Pro Val Leu Arg Asn
210 215 220
Val Glu Thr Asn Phe Leu Gly Phe Leu Leu Pro Leu Leu Ile Met Ser
225 230 235 240
Tyr Cys Tyr Phe Arg Ile Ile Gln Thr Leu Phe Ser Cys Lys Asn His
245 250 255
Lys Lys Ala Lys Ala Ile Lys Leu Ile Leu Leu Val Val Ile Val Phe
260 265 270
Phe Leu Phe Trp Thr Pro Tyr Asn Val Met Ile Phe Leu Glu Thr Leu
275 280 285
Lys Leu Tyr Asp Phe Phe Pro Ser Cys Asp Met Arg Lys Asp Leu Arg
290 295 300
Leu Ala Leu Ser Val Thr Glu Thr Val Ala Phe Ser His Cys Cys Leu
305 310 315 320
Asn Pro Leu Ile Tyr Ala Phe Ala Gly Glu Lys Phe Arg Arg Tyr Leu
325 330 335
Tyr His Leu Tyr Gly Lys Cys Leu Ala Val Leu Cys Gly Arg Ser Val
340 345 350
His Val Asp Phe Ser Ser Ser Glu Ser Gln Arg Ser Arg His Gly Ser
355 360 365
Val Leu Ser Ser Asn Phe Thr Tyr His Thr Ser Asp Gly Asp Ala Leu
370 375 380
Leu Leu Leu
385
<210>61
<211>368
<212>PRT
<213>人
<400>61
Met Val Leu Glu Val Ser Asp His Gln Val Leu Asn Asp Ala Glu Val
1 5 10 15
Ala Ala Leu Leu Glu Asn Phe Ser Ser Ser Tyr Asp Tyr Gly Glu Asn
20 25 30
Glu Ser Asp Ser Cys Cys Thr Ser Pro Pro Cys Pro Gln Asp Phe Ser
35 40 45
Leu Asn Phe Asp Arg Ala Phe Leu Pro Ala Leu Tyr Ser Leu Leu Phe
50 55 60
Leu Leu Gly Leu Leu Gly Asn Gly Ala Val Ala Ala Val Leu Leu Ser
65 70 75 80
Arg Arg Thr Ala Leu Ser Ser Thr Asp Thr Phe Leu Leu His Leu Ala
85 90 95
Val Ala Asp Thr Leu Leu Val Leu Thr Leu Pro Leu Trp Ala Val Asp
100 105 110
Ala Ala Val Gln Trp Val Phe Gly Ser Gly Leu Cys Lys Val Ala Gly
115 120 125
Ala Leu Phe Asn Ile Asn Phe Tyr Ala Gly Ala Leu Leu Leu Ala Cys
130 135 140
Ile Ser Phe Asp Arg Tyr Leu Asn Ile Val His Ala Thr Gln Leu Tyr
145 150 155 160
Arg Arg Gly Pro Pro Ala Arg Val Thr Leu Thr Cys Leu Ala Val Trp
165 170 175
Gly Leu Cys Leu Leu Phe Ala Leu Pro Asp Phe Ile Phe Leu Ser Ala
180 185 190
His His Asp Glu Arg Leu Asn Ala Thr His Cys Gln Tyr Asn Phe Pro
195 200 205
Gln Val Gly Arg Thr Ala Leu Arg Val Leu Gln Leu Val Ala Gly Phe
210 215 220
Leu Leu Pro Leu Leu Val Met Ala Tyr Cys Tyr Ala His Ile Leu Ala
225 230 235 240
Val Leu Leu Val Ser Arg Gly Gln Arg Arg Leu Arg Ala Met Arg Leu
245 250 255
Val Val Val Val Val Val Ala Phe Ala Leu Cys Trp Thr Pro Tyr His
260 265 270
Leu Val Val Leu Val Asp Ile Leu Met Asp Leu Gly Ala Leu Ala Arg
275 280 285
Asn Cys Gly Arg Glu Ser Arg Val Asp Val Ala Lys Ser Val Thr Ser
290 295 300
Gly Leu Gly Tyr Met His Cys Cys Leu Asn Pro Leu Leu Tyr Ala Phe
305 310 315 320
Val Gly Val Lys Phe Arg Glu Arg Met Trp Met Leu Leu Leu Arg Leu
325 330 335
Gly Cys Pro Asn Gln Arg Gly Leu Gln Arg Gln Pro Ser Ser Ser Arg
340 345 350
Arg Asp Ser Ser Trp Ser Glu Thr Ser Glu Ala Ser Tyr Ser Gly Leu
355 360 365
<210>62
<211>267
<212>PRT
<213>人
<400>62
Met Val Leu Glu Val Ser Asp His Gln Val Leu Asn Asp Ala Glu Val
1 5 10 15
Ala Ala Leu Leu Glu Asn Phe Ser Ser Ser Tyr Asp Tyr Gly Glu Asn
20 25 30
Glu Ser Asp Ser Cys Cys Thr Ser Pro Pro Cys Pro Gln Asp Phe Ser
35 40 45
Leu Asn Phe Asp Arg Ala Phe Leu Pro Ala Leu Tyr Ser Leu Leu Phe
50 55 60
Leu Leu Gly Leu Leu Gly Asn Gly Ala Val Ala Ala Val Leu Leu Ser
65 70 75 80
Arg Arg Thr Ala Leu Ser Ser Thr Asp Thr Phe Leu Leu His Leu Ala
85 90 95
Val Ala Asp Thr Leu Leu Val Leu Thr Leu Pro Leu Trp Ala Val Asp
100 105 110
Ala Ala Val Gln Trp Val Phe Gly Ser Gly Leu Cys Lys Val Ala Gly
115 120 125
Ala Leu Phe Asn Ile Asn Phe Tyr Ala Gly Ala Leu Leu Leu Ala Cys
130 135 140
Ile Ser Phe Asp Arg Tyr Leu Asn Ile Val His Ala Thr Gln Leu Tyr
145 150 155 160
Arg Arg Gly Pro Pro Ala Arg Val Thr Leu Thr Cys Leu Ala Val Trp
165 170 175
Gly Leu Cys Leu Leu Phe Ala Leu Pro Asp Phe Ile Phe Leu Ser Ala
180 185 190
His His Asp Glu Arg Leu Asn Ala Thr His Cys Gln Tyr Asn Phe Pro
195 200 205
Gln Gly Ser Ser Ser Gly Ser Gly Cys Gly Cys Cys Ser Cys Ala Trp
210 215 220
Ala Ala Pro Thr Arg Glu Gly Ser Arg Gly Ser His Arg Leu Pro Ala
225 230 235 240
Gly Ile His Pro Gly Leu Arg Pro Gln Arg Pro Pro Thr Arg Ala Cys
245 250 255
Glu Ala Gly Ile Arg Ala Pro Leu Ser Pro Thr
260 265
<210>63
<211>1500
<212>PRT
<213>人
<400>63
Met Asp Pro Ser Met Gly Val Asn Ser Val Thr Ile Ser Val Glu Gly
1 5 10 15
Met Thr Cys Asn Ser Cys Val Trp Thr Ile Glu Gln Gln Ile Gly Lys
20 25 30
Val Asn Gly Val His His Ile Lys Val Ser Leu Glu Glu Lys Asn Ala
35 40 45
Thr Ile Ile Tyr Asp Pro Lys Leu Gln Thr Pro Lys Thr Leu Gln Glu
50 55 60
Ala Ile Asp Asp Met Gly Phe Asp Ala Val Ile His Asn Pro Asp Pro
65 70 75 80
Leu Pro Val Leu Thr Asp Thr Leu Phe Leu Thr Val Thr Ala Ser Leu
85 90 95
Thr Leu Pro Trp Asp His Ile Gln Ser Thr Leu Leu Lys Thr Lys Gly
100 105 110
Val Thr Asp Ile Lys Ile Tyr Pro Gln Lys Arg Thr Val Ala Val Thr
115 120 125
Ile Ile Pro Ser Ile Val Asn Ala Asn Gln Ile Lys Glu Leu Val Pro
130 135 140
Glu Leu Ser Leu Asp Thr Gly Thr Leu Glu Lys Lys Ser Gly Ala Cys
145 150 155 160
Glu Asp His Ser Met Ala Gln Ala Gly Glu Val Val Leu Lys Met Lys
165 170 175
Val Glu Gly Met Thr Cys His Ser Cys Thr Ser Thr Ile Glu Gly Lys
180 185 190
Ile Gly Lys Leu Gln Gly Val Gln Arg Ile Lys Val Ser Leu Asp Asn
195 200 205
Gln Glu Ala Thr Ile Val Tyr Gln Pro His Leu Ile Ser Val Glu Glu
210 215 220
Met Lys Lys Gln Ile Glu Ala Met Gly Phe Pro Ala Phe Val Lys Lys
225 230 235 240
Gln Pro Lys Tyr Leu Lys Leu Gly Ala Ile Asp Val Glu Arg Leu Lys
245 250 255
Asn Thr Pro Val Lys Ser Ser Glu Gly Ser Gln Gln Arg Ser Pro Ser
260 265 270
Tyr Thr Asn Asp Ser Thr Ala Thr Phe Ile Ile Asp Gly Met His Cys
275 280 285
Lys Ser Cys Val Ser Asn Ile Glu Ser Thr Leu Ser Ala Leu Gln Tyr
290 295 300
Val Ser Ser Ile Val Val Ser Leu Glu Asn Arg Ser Ala Ile Val Lys
305 310 315 320
Tyr Asn Ala Ser Ser Val Thr Pro Glu Ser Leu Arg Lys Ala Ile Glu
325 330 335
Ala Val Ser Pro Gly Leu Tyr Arg Val Ser Ile Thr Ser Glu Val Glu
340 345 350
Ser Thr Ser Asn Ser Pro Ser Ser Ser Ser Leu Gln Lys Ile Pro Leu
355 360 365
Asn Val Val Ser Gln Pro Leu Thr Gln Glu Thr Val Ile Asn Ile Asp
370 375 380
Gly Met Thr Cys Asn Ser Cys Val Gln Ser Ile Glu Gly Val Ile Ser
385 390 395 400
Lys Lys Pro Gly Val Lys Ser Ile Arg Val Ser Leu Ala Asn Ser Asn
405 410 415
Gly Thr Val Glu Tyr Asp Pro Leu Leu Thr Ser Pro Glu Thr Leu Arg
420 425 430
Gly Ala Ile Glu Asp Met Gly Phe Asp Ala Thr Leu Ser Asp Thr Asn
435 440 445
Glu Pro Leu Val Val Ile Ala Gln Pro Ser Ser Glu Met Pro Leu Leu
450 455 460
Thr Ser Thr Asn Glu Phe Tyr Thr Lys Gly Met Thr Pro Val Gln Asp
465 470 475 480
Lys Glu Glu Gly Lys Asn Ser Ser Lys Cys Tyr Ile Gln Val Thr Gly
485 490 495
Met Thr Cys Ala Ser Cys Val Ala Asn Ile Glu Arg Asn Leu Arg Arg
500 505 510
Glu Glu Gly Ile Tyr Ser Ile Leu Val Ala Leu Met Ala Gly Lys Ala
515 520 525
Glu Val Arg Tyr Asn Pro Ala Val Ile Gln Pro Pro Met Ile Ala Glu
530 535 540
Phe Ile Arg Glu Leu Gly Phe Gly Ala Thr Val Ile Glu Asn Ala Asp
545 550 555 560
Glu Gly Asp Gly Val Leu Glu Leu Val Val Arg Gly Met Thr Cys Ala
565 570 575
Ser Cys Val His Lys Ile Glu Ser Ser Leu Thr Lys His Arg Gly Ile
580 585 590
Leu Tyr Cys Ser Val Ala Leu Ala Thr Asn Lys Ala His Ile Lys Tyr
595 600 605
Asp Pro Glu Ile Ile Gly Pro Arg Asp Ile Ile His Thr Ile Glu Ser
610 615 620
Leu Gly Phe Glu Ala Ser Leu Val Lys Lys Asp Arg Ser Ala Ser His
625 630 635 640
Leu Asp His Lys Arg Glu Ile Arg Gln Trp Arg Arg Ser Phe Leu Val
645 650 655
Ser Leu Phe Phe Cys Ile Pro Val Met Gly Leu Met Ile Tyr Met Met
660 665 670
Val Met Asp His His Phe Ala Thr Leu His His Asn Gln Asn Met Ser
675 680 685
Lys Glu Glu Met Ile Asn Leu His Ser Ser Met Phe Leu Glu Arg Gln
690 695 700
Ile Leu Pro Gly Leu Ser Val Met Asn Leu Leu Ser Phe Leu Leu Cys
705 710 715 720
Val Pro Val Gln Phe Phe Gly Gly Trp Tyr Phe Tyr Ile Gln Ala Tyr
725 730 735
Lys Ala Leu Lys His Lys Thr Ala Asn Met Asp Val Leu Ile Val Leu
740 745 750
Ala Thr Thr Ile Ala Phe Ala Tyr Ser Leu Ile Ile Leu Leu Val Ala
755 760 765
Met Tyr Glu Arg Ala Lys Val Asn Pro Ile Thr Phe Phe Asp Thr Pro
770 775 780
Pro Met Leu Phe Val Phe Ile Ala Leu Gly Arg Trp Leu Glu His Ile
785 790 795 800
Ala Lys Gly Lys Thr Ser Glu Ala Leu Ala Lys Leu Ile Ser Leu Gln
805 810 815
Ala Thr Glu Ala Thr Ile Val Thr Leu Asp Ser Asp Asn Ile Leu Leu
820 825 830
Ser Glu Glu Gln Val Asp Val Glu Leu Val Gln Arg Gly Asp Ile Ile
835 840 845
Lys Val Val Pro Gly Gly Lys Phe Pro Val Asp Gly Arg Val Ile Glu
850 855 860
Gly His Ser Met Val Asp Glu Ser Leu Ile Thr Gly Glu Ala Met Pro
865 870 875 880
Val Ala Lys Lys Pro Gly Ser Thr Val Ile Ala Gly Ser Ile Asn Gln
885 890 895
Asn Gly Ser Leu Leu Ile Cys Ala Thr His Val Gly Ala Asp Thr Thr
900 905 910
Leu Ser Gln Ile Val Lys Leu Val Glu Glu Ala Gln Thr Ser Lys Ala
915 920 925
Pro Ile Gln Gln Phe Ala Asp Lys Leu Ser Gly Tyr Phe Val Pro Phe
930 935 940
Ile Val Phe Val Ser Ile Ala Thr Leu Leu Val Trp Ile Val Ile Gly
945 950 955 960
Phe Leu Asn Phe Glu Ile Val Glu Thr Tyr Phe Pro Gly Tyr Asn Arg
965 970 975
Ser Ile Ser Arg Thr Glu Thr Ile Ile Arg Phe Ala Phe Gln Ala Ser
980 985 990
Ile Thr Val Leu Cys Ile Ala Cys Pro Cys Ser Leu Gly Leu Ala Thr
995 1000 1005
Pro Thr Ala Val Met Val Gly Thr Gly Val Gly Ala Gln Asn Gly Ile
1010 1015 1020
Leu Ile Lys Gly Gly Glu Pro Leu Glu Met Ala His Lys Val Lys Val
1025 1030 1035 1040
Val Val Phe Asp Lys Thr Gly Thr Ile Thr His Gly Thr Pro Val Val
1045 1050 1055
Asn Gln Val Lys Val Leu Thr Glu Ser Asn Arg Ile Ser His His Lys
1060 1065 1070
Ile Leu Ala Ile Val Gly Thr Ala Glu Ser Asn Ser Glu His Pro Leu
1075 1080 1085
Gly Thr Ala Ile Thr Lys Tyr Cys Lys Gln Glu Leu Asp Thr Glu Thr
1090 1095 1100
Leu Gly Thr Cys Ile Asp Phe Gln Val Val Pro Gly Cys Gly Ile Ser
1105 1110 1115 1120
Cys Lys Val Thr Asn Ile Glu Gly Leu Leu His Lys Asn Asn Trp Asn
1125 1130 1135
Ile Glu Asp Asn Asn Ile Lys Asn Ala Ser Leu Val Gln Ile Asp Ala
1140 1145 1150
Ser Asn Glu Gln Ser Ser Thr Ser Ser Ser Met lle Ile Asp Ala Gln
1155 1160 1165
Ile Ser Asn Ala Leu Asn Ala Gln Gln Tyr Lys Val Leu Ile Gly Asn
1170 1175 1180
Arg Glu Trp Met Ile Arg Asn Gly Leu Val Ile Asn Asn Asp Val Asn
1185 1190 1195 1200
Asp Phe Met Thr Glu His Glu Arg Lys Gly Arg Thr Ala Val Leu Val
1205 1210 1215
Ala Val Asp Asp Glu Leu Cys Gly Leu Ile Ala Ile Ala Asp Thr Val
1220 1225 1230
Lys Pro Glu Ala Glu Leu Ala Ile His Ile Leu Lys Ser Met Gly Leu
1235 1240 1245
Glu Val Val Leu Met Thr Gly Asp Asn Ser Lys Thr Ala Arg Ser Ile
1250 1255 1260
Ala Ser Gln Val Gly Ile Thr Lys Val Phe Ala Glu Val Leu Pro Ser
1265 1270 1275 1280
His Lys Val Ala Lys Val Lys Gln Leu Gln Glu Glu Gly Lys Arg Val
1285 1290 1295
Ala Met Val Gly Asp Gly Ile Asn Asp Ser Pro Ala Leu Ala Met Ala
1300 1305 1310
Asn Val Gly Ile Ala Ile Gly Thr Gly Thr Asp Val Ala Ile Glu Ala
1315 1320 1325
Ala Asp Val Val Leu Ile Arg Asn Asp Leu Leu Asp Val Val Ala Ser
1330 1335 1340
Ile Asp Leu Ser Arg Glu Thr Val Lys Arg Ile Arg Ile Asn Phe Val
1345 1350 1355 1360
Phe Ala Leu Ile Tyr Asn Leu Val Gly Ile Pro Ile Ala Ala Gly Val
1365 1370 1375
Phe Met Pro Ile Gly Leu Val Leu Gln Pro Trp Met Gly Ser Ala Ala
1380 1385 1390
Met Ala Ala Ser Ser Val Ser Val Val Leu Ser Ser Leu Phe Leu Lys
1395 1400 1405
Leu Tyr Arg Lys Pro Thr Tyr Glu Ser Tyr Glu Leu Pro Ala Arg Ser
1410 1415 1420
Gln Ile Gly Gln Lys Ser Pro Ser Glu Ile Ser Val His Val Gly Ile
1425 1430 1435 1440
Asp Asp Thr Ser Arg Asn Ser Pro Lys Leu Gly Leu Leu Asp Arg Ile
1445 1450 1455
Val Asn Tyr Ser Arg Ala Ser Ile Asn Ser Leu Leu Ser Asp Lys Arg
1460 1465 1470
Ser Leu Asn Ser Val Val Thr Ser Glu Pro Asp Lys His Ser Leu Leu
1475 1480 1485
Val Gly Asp Phe Arg Glu Asp Asp Asp Thr Ala Leu
1490 1495 1500
<210>64
<211>1113
<212>PRT
<213>人
<400>64
Met Phe Arg Arg Ser Leu Asn Arg Phe Cys Ala Gly Glu Glu Lys Arg
1 5 10 15
Val Gly Thr Arg Thr Val Phe Val Gly Asn His Pro Val Ser Glu Thr
20 25 30
Glu Ala Tyr Ile Ala Gln Arg Phe Cys Asp Asn Arg Ile Val Ser Ser
35 40 45
Lys Tyr Thr Leu Trp Asn Phe Leu Pro Lys Asn Leu Phe Glu Gln Phe
50 55 60
Arg Arg Ile Ala Asn Phe Tyr Phe Leu Ile Ile Phe Leu Val Gln Val
65 70 75 80
Thr Val Asp Thr Pro Thr Ser Pro Val Thr Ser Gly Leu Pro Leu Phe
85 90 95
Phe Val Ile Thr Val Thr Ala Ile Lys Gln Gly Tyr Glu Asp Cys Leu
100 105 110
Arg His Arg Ala Asp Asn Glu Val Asn Lys Ser Thr Val Tyr Ile Ile
115 120 125
Glu Asn Ala Lys Arg Val Arg Lys Glu Ser Glu Lys Ile Lys Val Gly
130 135 140
Asp Val Val Glu Val Gln Ala Asp Glu Thr Phe Pro Cys Asp Leu Ile
145 150 155 160
Leu Leu Ser Ser Cys Thr Thr Asp Gly Thr Cys Tyr Val Thr Thr Ala
165 170 175
Ser Leu Asp Gly Glu Ser Asn Cys Lys Thr His Tyr Ala Val Arg Asp
180 185 190
Thr Ile Ala Leu Cys Thr Ala Glu Ser Ile Asp Thr Leu Arg Ala Ala
195 200 205
Ile Glu Cys Glu Gln Pro Gln Pro Asp Leu Tyr Lys Phe Val Gly Arg
210 215 220
Ile Asn Ile Tyr Ser Asn Ser Leu Glu Ala Val Ala Arg Ser Leu Gly
225 230 235 240
Pro Glu Asn Leu Leu Leu Lys Gly Ala Thr Leu Lys Asn Thr Glu Lys
245 250 255
Ile Tyr Gly Val Ala Val Tyr Thr Gly Met Glu Thr Lys Met Ala Leu
260 265 270
Asn Tyr Gln Gly Lys Ser Gln Lys Arg Ser Ala Val Glu Lys Ser Ile
275 280 285
Asn Ala Phe Leu Ile Val Tyr Leu Phe Ile Leu Leu Thr Lys Ala Ala
290 295 300
Val Cys Thr Thr Leu Lys Tyr Val Trp Gln Ser Thr Pro Tyr Asn Asp
305 310 315 320
Glu Pro Trp Tyr Asn Gln Lys Thr Gln Lys Glu Arg Glu Thr Leu Lys
325 330 335
Val Leu Lys Met Phe Thr Asp Phe Leu Ser Phe Met Val Leu Phe Asn
340 345 350
Phe Ile Ile Pro Val Ser Met Tyr Val Thr Val Glu Met Gln Lys Phe
355 360 365
Leu Gly Ser Phe Phe Ile Ser Trp Asp Lys Asp Phe Tyr Asp Glu Glu
370 375 380
Ile Asn Glu Gly Ala Leu Val Asn Thr Ser Asp Leu Asn Glu Glu Leu
385 390 395 400
Gly Gln Val Asp Tyr Val Phe Thr Asp Lys Thr Gly Thr Leu Thr Glu
405 410 415
Asn Ser Met Glu Phe Ile Glu Cys Cys Ile Asp Gly His Lys Tyr Lys
420 425 430
Gly Val Thr Gln Glu Val Asp Gly Leu Ser Gln Thr Asp Gly Thr Leu
435 440 445
Thr Tyr Phe Asp Lys Val Asp Lys Asn Arg Glu Glu Leu Phe Leu Arg
450 455 460
Ala Leu Cys Leu Cys His Thr Val Glu Ile Lys Thr Asn Asp Ala Val
465 470 475 480
Asp Gly Ala Thr Glu Ser Ala Glu Leu Thr Tyr Ile Ser Ser Ser Pro
485 490 495
Asp Glu Ile Ala Leu Val Lys Gly Ala Lys Arg Tyr Gly Phe Thr Phe
500 505 510
Leu Gly Asn Arg Asn Gly Tyr Met Arg Val Glu Asn Gln Arg Lys Glu
515 520 525
Ile Glu Glu Tyr Glu Leu Leu His Thr Leu Asn Phe Asp Ala Val Arg
530 535 540
Arg Arg Met Ser Val Ile Val Lys Thr Gln Glu Gly Asp Ile Leu Leu
545 550 555 560
Phe Cys Lys Gly Ala Asp Ser Ala Val Phe Pro Arg Val Gln Asn His
565 570 575
Glu Ile Glu Leu Thr Lys Val His Val Glu Arg Asn Ala Met Asp Gly
580 585 590
Tyr Arg Thr Leu Cys Val Ala Phe Lys Glu Ile Ala Pro Asp Asp Tyr
595 600 605
Glu Arg Ile Asn Arg Gln Leu Ile Glu Ala Lys Met Ala Leu Gln Asp
610 615 620
Arg Glu Glu Lys Met Glu Lys Val Phe Asp Asp Ile Glu Thr Asn Met
625 630 635 640
Asn Leu Ile Gly Ala Thr Ala Val Glu Asp Lys Leu Gln Asp Gln Ala
645 650 655
Ala Glu Thr Ile Glu Ala Leu His Ala Ala Gly Leu Lys Val Trp Val
660 665 670
Leu Thr Gly Asp Lys Met Glu Thr Ala Lys Ser Thr Cys Tyr Ala Cys
675 680 685
Arg Leu Phe Gln Thr Asn Thr Glu Leu Leu Glu Leu Thr Thr Lys Thr
690 695 700
Ile Glu Glu Ser Glu Arg Lys Glu Asp Arg Leu His Glu Leu Leu Ile
705 710 715 720
Glu Tyr Arg Lys Lys Leu Leu His Glu Phe Pro Lys Ser Thr Arg Ser
725 730 735
Phe Lys Lys Ala Trp Thr Glu His Gln Glu Tyr Gly Leu Ile Ile Asp
740 745 750
Gly Ser Thr Leu Ser Leu Ile Leu Asn Ser Ser Gln Asp Ser Ser Ser
755 760 765
Asn Asn Tyr Lys Ser Ile Phe Leu Gln Ile Cys Met Lys Cys Thr Ala
770 775 780
Val Leu Cys Cys Arg Met Ala Pro Leu Gln Lys Ala Gln Ile Val Arg
785 790 795 800
Met Val Lys Asn Leu Lys Gly Ser Pro Ile Thr Leu Ser Ile Gly Asp
805 810 815
Gly Ala Asn Asp Val Ser Met Ile Leu Glu Ser His Val Gly Ile Gly
820 825 830
Lys Glu Gly Arg Gln Ala Ala Arg Asn Ser Asp Tyr Ser Val Pro Lys
835 840 845
Phe Lys His Leu Lys Lys Leu Leu Leu Ala His Gly His Leu Tyr Tyr
850 855 860
Val Arg Ile Ala His Leu Val Gln Tyr Phe Phe Tyr Lys Asn Leu Cys
865 870 875 880
Phe Ile Leu Pro Gln Phe Leu Tyr Gln Phe Phe Cys Gly Phe Ser Gln
885 890 895
Gln Pro Leu Tyr Asp Ala Ala Tyr Leu Thr Met Tyr Asn Ile Cys Phe
900 905 910
Thr Ser Leu Pro Ile Leu Ala Tyr Ser Leu Leu Glu Gln His Ile Asn
915 920 925
Ile Asp Thr Leu Thr Ser Asp Pro Arg Leu Tyr Met Lys Ile Ser Gly
930 935 940
Asn Ala Met Leu Gln Leu Gly Pro Phe Leu Tyr Trp Thr Phe Leu Ala
945 950 955 960
Ala Phe Glu Gly Thr Val Phe Phe Phe Gly Thr Tyr Phe Leu Phe Gln
965 970 975
Thr Ala Ser Leu Glu Glu Asn Gly Lys Val Tyr Gly Asn Trp Thr Phe
980 985 990
Gly Thr Ile Val Phe Thr Val Leu Val Phe Thr Val Thr Leu Lys Leu
995 1000 1005
Ala Leu Asp Thr Arg Phe Trp Thr Trp Ile Asn His Phe Val Ile Trp
1010 1015 1020
Gly Ser Leu Ala Phe Tyr Val Phe Phe Ser Phe Phe Trp Gly Gly Ile
1025 1030 1035 1040
Ile Trp Pro Phe Leu Lys Gln Gln Arg Met Tyr Phe Val Phe Ala Gln
1045 1050 1055
Met Leu Ser Ser Val Ser Thr Trp Leu Ala Ile Ile Leu Leu Ile Phe
1060 1065 1070
Ile Ser Leu Phe Pro Glu Ile Leu Leu Ile Val Leu Lys Asn Val Arg
1075 1080 1085
Arg Arg Ser Ala Arg Asn Pro Asn Leu Glu Leu Pro Met Leu Leu Ser
1090 1095 1100
Tyr Lys His Thr Asp Ser Gly Tyr Ser
1105 1110
<210>65
<211>415
<212>PRT
<213>人
<400>65
Met Glu Leu Arg Lys Tyr Gly Pro Gly Arg Leu Ala Gly Thr Val Ile
1 5 10 15
Gly Gly Ala Ala Gln Ser Lys Ser Gln Thr Lys Ser Asp Ser Ile Thr
20 25 30
Lys Glu Phe Leu Pro Gly Leu Tyr Thr Ala Pro Ser Ser Pro Phe Pro
35 40 45
Pro Ser Gln Val Ser Asp His Gln Val Leu Asn Asp Ala Glu Val Ala
50 55 60
Ala Leu Leu Glu Asn Phe Ser Ser Ser Tyr Asp Tyr Gly Glu Asn Glu
65 70 75 80
Ser Asp Ser Cys Cys Thr Ser Pro Pro Cys Pro Gln Asp Phe Ser Leu
85 90 95
Asn Phe Asp Arg Ala Phe Leu Pro Ala Leu Tyr Ser Leu Leu Phe Leu
100 105 110
Leu Gly Leu Leu Gly Asn Gly Ala Val Ala Ala Val Leu Leu Ser Arg
115 120 125
Arg Thr Ala Leu Ser Ser Thr Asp Thr Phe Leu Leu His Leu Ala Val
130 135 140
Ala Asp Thr Leu Leu Val Leu Thr Leu Pro Leu Trp Ala Val Asp Ala
145 150 155 160
Ala Val Gln Trp Val Phe Gly Ser Gly Leu Cys Lys Val Ala Gly Ala
165 170 175
Leu Phe Asn Ile Asn Phe Tyr Ala Gly Ala Leu Leu Leu Ala Cys Ile
180 185 190
Ser Phe Asp Arg Tyr Leu Asn Ile Val His Ala Thr Gln Leu Tyr Arg
195 200 205
Arg Gly Pro Pro Ala Arg Val Thr Leu Thr Cys Leu Ala Val Trp Gly
210 215 220
Leu Cys Leu Leu Phe Ala Leu Pro Asp Phe Ile Phe Leu Ser Ala His
225 230 235 240
His Asp Glu Arg Leu Asn Ala Thr His Cys Gln Tyr Asn Phe Pro Gln
245 250 255
Val Gly Arg Thr Ala Leu Arg Val Leu Gln Leu Val Ala Gly Phe Leu
260 265 270
Leu Pro Leu Leu Val Met Ala Tyr Cys Tyr Ala His Ile Leu Ala Val
275 280 285
Leu Leu Val Ser Arg Gly Gln Arg Arg Leu Arg Ala Met Arg Leu Val
290 295 300
Val Val Val Val Val Ala Phe Ala Leu Cys Trp Thr Pro Tyr His Leu
305 310 315 320
Val Val Leu Val Asp Ile Leu Met Asp Leu Gly Ala Leu Ala Arg Asn
325 330 335
Cys Gly Arg Glu Ser Arg Val Asp Val Ala Lys Ser Val Thr Ser Gly
340 345 350
Leu Gly Tyr Met His Cys Cys Leu Asn Pro Leu Leu Tyr Ala Phe Val
355 360 365
Gly Val Lys Phe Arg Glu Arg Met Trp Met Leu Leu Leu Arg Leu Gly
370 375 380
Cys Pro Asn Gln Arg Gly Leu Gln Arg Gln Pro Ser Ser Ser Arg Arg
385 390 395 400
Asp Ser Ser Trp Ser Glu Thr Ser Glu Ala Ser Tyr Ser Gly Leu
405 410 415
<210>66
<211>255
<212>PRT
<213>人
<400>66
Met Ser Ser His Arg Arg Lys Ala Lys Gly Arg Asn Arg Arg Ser His
1 5 10 15
Arg Ala Met Arg Val Ala His Leu Glu Leu Ala Thr Tyr Glu Leu Ala
20 25 30
Ala Thr Glu Ser Asn Pro Glu Ser Ser His Pro Gly Tyr Glu Ala Ala
35 40 45
Met Ala Asp Arg Pro Gln Pro Gly Trp Arg Glu Ser Leu Lys Met Arg
50 55 60
Val Ser Lys Pro Phe Gly Met Leu Met Leu Ser Ile Trp Ile Leu Leu
65 70 75 80
Phe Val Cys Tyr Tyr Leu Ser Tyr Tyr Leu Cys Ser Gly Ser Ser Tyr
85 90 95
Phe Val Leu Ala Asn Gly His Ile Leu Pro Asn Ser Glu Asn Ala His
100 105 110
Gly Gln Ser Leu Glu Glu Asp Ser Ala Leu Glu Ala Leu Leu Asn Phe
115 120 125
Phe Phe Pro Thr Thr Cys Asn Leu Arg Glu Asn Gln Val Ala Lys Pro
130 135 140
Cys Asn Glu Leu Gln Asp Leu Ser Glu Ser Glu Cys Leu Arg His Lys
145 150 155 160
Cys Cys Phe Ser Ser Ser Gly Thr Thr Ser Phe Lys Cys Phe Ala Pro
165 170 175
Phe Arg Asp Val Pro Lys Gln Met Met Gln Met Phe Gly Leu Gly Ala
180 185 190
Ile Ser Leu Ile Leu Val Cys Leu Pro Ile Tyr Cys Arg Ser Leu Phe
195 200 205
Trp Arg Ser Glu Pro Ala Asp Asp Leu Gln Arg Gln Asp Asn Arg Val
210 215 220
Val Thr Gly Leu Lys Lys Gln Arg Arg Lys Arg Lys Arg Lys Ser Glu
225 230 235 240
Met Leu Gln Lys Ala Ala Arg Gly Arg Glu Glu His Gly Asp Glu
245 250 255
<210>67
<211>1128
<212>PRT
<213>人
<400>67
Met Gln Met Val Pro Ser Leu Pro Pro Ala Ser Glu Cys Ala Gly Glu
1 5 10 15
Glu Lys Arg Val Gly Thr Arg Thr Val Phe Val Gly Asn His Pro Val
20 25 30
Ser Glu Thr Glu Ala Tyr Ile Ala Gln Arg Phe Cys Asp Asn Arg Ile
35 40 45
Val Ser Ser Lys Tyr Thr Leu Trp Asn Phe Leu Pro Lys Asn Leu Phe
50 55 60
Glu Gln Phe Arg Arg Ile Ala Asn Phe Tyr Phe Leu Ile Ile Phe Leu
65 70 75 80
Val Gln Val Thr Val Asp Thr Pro Thr Ser Pro Val Thr Ser Gly Leu
85 90 95
Pro Leu Phe Phe Val Ile Thr Val Thr Ala Ile Lys Gln Gly Tyr Glu
100 105 110
Asp Cys Leu Arg His Arg Ala Asp Asn Glu Val Asn Lys Ser Thr Val
115 120 125
Tyr Ile Ile Glu Asn Ala Lys Arg Val Arg Lys Glu Ser Glu Lys Ile
130 135 140
Lys Val Gly Asp Val Val Glu Val Gln Ala Asp Glu Thr Phe Pro Cys
145 150 155 160
Asp Leu Ile Leu Leu Ser Ser Cys Thr Thr Asp Gly Thr Cys Tyr Val
165 170 175
Thr Thr Ala Ser Leu Asp Gly Glu Ser Asn Cys Lys Thr His Tyr Ala
180 185 190
Val Arg Asp Thr Ile Ala Leu Cys Thr Ala Glu Ser Ile Asp Thr Leu
195 200 205
Arg Ala Ala Ile Glu Cys Glu Gln Pro Gln Pro Asp Leu Tyr Lys Phe
210 215 220
Val Gly Arg Ile Asn Ile Tyr Ser Asn Ser Leu Glu Ala Val Ala Arg
225 230 235 240
Ser Leu Gly Pro Glu Asn Leu Leu Leu Lys Gly Ala Thr Leu Lys Asn
245 250 255
Thr Glu Lys Ile Tyr Gly Val Ala Val Tyr Thr Gly Met Glu Thr Lys
260 265 270
Met Ala Leu Asn Tyr Gln Gly Lys Ser Gln Lys Arg Ser Ala Val Glu
275 280 285
Lys Ser Ile Asn Ala Phe Leu Ile Val Tyr Leu Phe Ile Leu Leu Thr
290 295 300
Lys Ala Ala Val Cys Thr Thr Leu Lys Tyr Val Trp Gln Ser Thr Pro
305 310 315 320
Tyr Asn Asp Glu Pro Trp Tyr Asn Gln Lys Thr Gln Lys Glu Arg Glu
325 330 335
Thr Leu Lys Val Leu Lys Met Phe Thr Asp Phe Leu Ser Phe Met Val
340 345 350
Leu Phe Asn Phe Ile Ile Pro Val Ser Met Tyr Val Thr Val Glu Met
355 360 365
Gln Lys Phe Leu Gly Ser Phe Phe Ile Ser Trp Asp Lys Asp Phe Tyr
370 375 380
Asp Glu Glu Ile Asn Glu Gly Ala Leu Val Asn Thr Ser Asp Leu Asn
385 390 395 400
Glu Glu Leu Gly Gln Val Asp Tyr Val Phe Thr Asp Lys Thr Gly Thr
405 410 415
Leu Thr Glu Asn Ser Met Glu Phe Ile Glu Cys Cys Ile Asp Gly His
420 425 430
Lys Tyr Lys Gly Val Thr Gln Glu Val Asp Gly Leu Ser Gln Thr Asp
435 440 445
Gly Thr Leu Thr Tyr Phe Asp Lys Val Asp Lys Asn Arg Glu Glu Leu
450 455 460
Phe Leu Arg Ala Leu Cys Leu Cys His Thr Val Glu Ile Lys Thr Asn
465 470 475 480
Asp Ala Val Asp Gly Ala Thr Glu Ser Ala Glu Leu Thr Tyr Ile Ser
485 490 495
Ser Ser Pro Asp Glu Ile Ala Leu Val Lys Gly Ala Lys Arg Tyr Gly
500 505 510
Phe Thr Phe Leu Gly Asn Arg Asn Gly Tyr Met Arg Val Glu Asn Gln
515 520 525
Arg Lys Glu Ile Glu Glu Tyr Glu Leu Leu His Thr Leu Asn Phe Asp
530 535 540
Ala Val Arg Arg Arg Met Ser Val Ile Val Lys Thr Gln Glu Gly Asp
545 550 555 560
Ile Leu Leu Phe Cys Lys Gly Ala Asp Ser Ala Val Phe Pro Arg Val
565 570 575
Gln Asn His Glu Ile Glu Leu Thr Lys Val His Val Glu Arg Asn Ala
580 585 590
Met Asp Gly Tyr Arg Thr Leu Cys Val Ala Phe Lys Glu Ile Ala Pro
595 600 605
Asp Asp Tyr Glu Arg Ile Asn Arg Gln Leu Ile Glu Ala Lys Met Ala
610 615 620
Leu Gln Asp Arg Glu Glu Lys Met Glu Lys Val Phe Asp Asp Ile Glu
625 630 635 640
Thr Asn Met Asn Leu Ile Gly Ala Thr Ala Val Glu Asp Lys Leu Gln
645 650 655
Asp Gln Ala Ala Glu Thr Ile Glu Ala Leu His Ala Ala Gly Leu Lys
660 665 670
Val Trp Val Leu Thr Gly Asp Lys Met Glu Thr Ala Lys Ser Thr Cys
675 680 685
Tyr Ala Cys Arg Leu Phe Gln Thr Asn Thr Glu Leu Leu Glu Leu Thr
690 695 700
Thr Lys Thr Ile Glu Glu Ser Glu Arg Lys Glu Asp Arg Leu His Glu
705 710 715 720
Leu Leu Ile Glu Tyr Arg Lys Lys Leu Leu His Glu Phe Pro Lys Ser
725 730 735
Thr Arg Ser Phe Lys Lys Ala Trp Thr Glu His Gln Glu Tyr Gly Leu
740 745 750
Ile Ile Asp Gly Ser Thr Leu Ser Leu Ile Leu Asn Ser Ser Gln Asp
755 760 765
Ser Ser Ser Asn Asn Tyr Lys Ser Ile Phe Leu Gln Ile Cys Met Lys
770 775 780
Cys Thr Ala Val Leu Cys Cys Arg Met Ala Pro Leu Gln Lys Ala Gln
785 790 795 800
Ile Val Arg Met Val Lys Asn Leu Lys Gly Ser Pro Ile Thr Leu Ser
805 810 815
Ile Gly Asp Gly Ala Asn Asp Val Ser Met Ile Leu Glu Ser His Val
820 825 830
Gly Ile Gly Ile Lys Gly Lys Glu Gly Arg Gln Ala Ala Arg Asn Ser
835 840 845
Asp Tyr Ser Val Pro Lys Phe Lys His Leu Lys Lys Leu Leu Leu Ala
850 855 860
His Gly His Leu Tyr Tyr Val Arg Ile Ala His Leu Val Gln Tyr Phe
865 870 875 880
Phe Tyr Lys Asn Leu Cys Phe Ile Leu Pro Gln Phe Leu Tyr Gln Phe
885 890 895
Phe Cys Gly Phe Ser Gln Gln Pro Leu Tyr Asp Ala Ala Tyr Leu Thr
900 905 910
Met Tyr Asn Ile Cys Phe Thr Ser Leu Pro Ile Leu Ala Tyr Ser Leu
915 920 925
Leu Glu Gln His Ile Asn Ile Asp Thr Leu Thr Ser Asp Pro Arg Leu
930 935 940
Tyr Met Lys Ile Ser Gly Asn Ala Met Leu Gln Leu Gly Pro Phe Leu
945 950 955 960
Tyr Trp Thr Phe Leu Ala Ala Phe Glu Gly Thr Val Phe Phe Phe Gly
965 970 975
Thr Tyr Phe Leu Phe Gln Thr Ala Ser Leu Glu Glu Asn Gly Lys Val
980 985 990
Tyr Gly Asn Trp Thr Phe Gly Thr Ile Val Phe Thr Val Leu Val Phe
995 1000 1005
Thr Val Thr Leu Lys Leu Ala Leu Asp Thr Arg Phe Trp Thr Trp Ile
1010 1015 1020
Asn His Phe Val Ile Trp Gly Ser Leu Ala Phe Tyr Val Phe Phe Ser
1025 1030 1035 1040
Phe Phe Trp Gly Gly Ile Ile Trp Pro Phe Leu Lys Gln Gln Arg Met
1045 1050 1055
Tyr Phe Val Phe Ala Gln Met Leu Ser Ser Val Ser Thr Trp Leu Ala
1060 1065 1070
Ile Ile Leu Leu Ile Phe Ile Ser Leu Phe Pro Glu Ile Leu Leu Ile
1075 1080 1085
Val Leu Lys Asn Val Arg Arg Arg Ser Ala Arg Val Thr Lys Arg Leu
1090 1095 1100
Pro Ser Ser Gly Thr Ser Ala Ile Phe Met Leu Ser Gln Thr Ser Ser
1105 1110 1115 1120
Asn His Ser Phe Ser Trp Ser Glu
1125
<210>68
<211>1119
<212>PRT
<213>人
<400>68
Met Gln Met Val Pro Ser Leu Pro Pro Ala Ser Glu Cys Ala Gly Glu
1 5 10 15
Glu Lys Arg Val Gly Thr Arg Thr Val Phe Val Gly Asn His Pro Val
20 25 30
Ser Glu Thr Glu Ala Tyr Ile Ala Gln Arg Phe Cys Asp Asn Arg Ile
35 40 45
Val Ser Ser Lys Tyr Thr Leu Trp Asn Phe Leu Pro Lys Asn Leu Phe
50 55 60
Glu Gln Phe Arg Arg Ile Ala Asn Phe Tyr Phe Leu Ile Ile Phe Leu
65 70 75 80
Val Gln Val Thr Val Asp Thr Pro Thr Ser Pro Val Thr Ser Gly Leu
85 90 95
Pro Leu Phe Phe Val Ile Thr Val Thr Ala Ile Lys Gln Gly Tyr Glu
100 105 110
Asp Cys Leu Arg His Arg Ala Asp Asn Glu Val Asn Lys Ser Thr Val
115 120 125
Tyr Ile Ile Glu Asn Ala Lys Arg Val Arg Lys Glu Ser Glu Lys Ile
130 135 140
Lys Val Gly Asp Val Val Glu Val Gln Ala Asp Glu Thr Phe Pro Cys
145 150 155 160
Asp Leu Ile Leu Leu Ser Ser Cys Thr Thr Asp Gly Thr Cys Tyr Val
165 170 175
Thr Thr Ala Ser Leu Asp Gly Glu Ser Asn Cys Lys Thr His Tyr Ala
180 185 190
Val Arg Asp Thr Ile Ala Leu Cys Thr Ala Glu Ser Ile Asp Thr Leu
195 200 205
Arg Ala Ala Ile Glu Cys Glu Gln Pro Gln Pro Asp Leu Tyr Lys Phe
210 215 220
Val Gly Arg Ile Asn Ile Tyr Ser Asn Ser Leu Glu Ala Val Ala Arg
225 230 235 240
Ser Leu Gly Pro Glu Asn Leu Leu Leu Lys Gly Ala Thr Leu Lys Asn
245 250 255
Thr Glu Lys Ile Tyr Gly Val Ala Val Tyr Thr Gly Met Glu Thr Lys
260 265 270
Met Ala Leu Asn Tyr Gln Gly Lys Ser Gln Lys Arg Ser Ala Val Glu
275 280 285
Lys Ser Ile Asn Ala Phe Leu Ile Val Tyr Leu Phe Ile Leu Leu Thr
290 295 300
Lys Ala Ala Val Cys Thr Thr Leu Lys Tyr Val Trp Gln Ser Thr Pro
305 310 315 320
Tyr Asn Asp Glu Pro Trp Tyr Asn Gln Lys Thr Gln Lys Glu Arg Glu
325 330 335
Thr Leu Lys Val Leu Lys Met Phe Thr Asp Phe Leu Ser Phe Met Val
340 345 350
Leu Phe Asn Phe Ile Ile Pro Val Ser Met Tyr Val Thr Val Glu Met
355 360 365
Gln Lys Phe Leu Gly Ser Phe Phe Ile Ser Trp Asp Lys Asp Phe Tyr
370 375 380
Asp Glu Glu Ile Asn Glu Gly Ala Leu Val Asn Thr Ser Asp Leu Asn
385 390 395 400
Glu Glu Leu Gly Gln Val Asp Tyr Val Phe Thr Asp Lys Thr Gly Thr
405 410 415
Leu Thr Glu Asn Ser Met Glu Phe Ile Glu Cys Cys Ile Asp Gly His
420 425 430
Lys Tyr Lys Gly Val Thr Gln Glu Val Asp Gly Leu Ser Gln Thr Asp
435 440 445
Gly Thr Leu Thr Tyr Phe Asp Lys Val Asp Lys Asn Arg Glu Glu Leu
450 455 460
Phe Leu Arg Ala Leu Cys Leu Cys His Thr Val Glu Ile Lys Thr Asn
465 470 475 480
Asp Ala Val Asp Gly Ala Thr Glu Ser Ala Glu Leu Thr Tyr Ile Ser
485 490 495
Ser Ser Pro Asp Glu Ile Ala Leu Val Lys Gly Ala Lys Arg Tyr Gly
500 505 510
Phe Thr Phe Leu Gly Asn Arg Asn Gly Tyr Met Arg Val Glu Asn Gln
515 520 525
Arg Lys Glu Ile Glu Glu Tyr Glu Leu Leu His Thr Leu Asn Phe Asp
530 535 540
Ala Val Arg Arg Arg Met Ser Val Ile Val Lys Thr Gln Glu Gly Asp
545 550 555 560
Ile Leu Leu Phe Cys Lys Gly Ala Asp Ser Ala Val Phe Pro Arg Val
565 570 575
Gln Asn His Glu Ile Glu Leu Thr Lys Val His Val Glu Arg Asn Ala
580 585 590
Met Asp Gly Tyr Arg Thr Leu Cys Val Ala Phe Lys Glu Ile Ala Pro
595 600 605
Asp Asp Tyr Glu Arg Ile Asn Arg Gln Leu Ile Glu Ala Lys Met Ala
610 615 620
Leu Gln Asp Arg Glu Glu Lys Met Glu Lys Val Phe Asp Asp Ile Glu
625 630 635 640
Thr Asn Met Asn Leu Ile Gly Ala Thr Ala Val Glu Asp Lys Leu Gln
645 650 655
Asp Gln Ala Ala Glu Thr Ile Glu Ala Leu His Ala Ala Gly Leu Lys
660 665 670
Val Trp Val Leu Thr Gly Asp Lys Met Glu Thr Ala Lys Ser Thr Cys
675 680 685
Tyr Ala Cys Arg Leu Phe Gln Thr Asn Thr Glu Leu Leu Glu Leu Thr
690 695 700
Thr Lys Thr Ile Glu Glu Ser Glu Arg Lys Glu Asp Arg Leu His Glu
705 710 715 720
Leu Leu Ile Glu Tyr Arg Lys Lys Leu Leu His Glu Phe Pro Lys Ser
725 730 735
Thr Arg Ser Phe Lys Lys Ala Trp Thr Glu His Gln Glu Tyr Gly Leu
740 745 750
Ile Ile Asp Gly Ser Thr Leu Ser Leu Ile Leu Asn Ser Ser Gln Asp
755 760 765
Ser Ser Ser Asn Asn Tyr Lys Ser Ile Phe Leu Gln Ile Cys Met Lys
770 775 780
Cys Thr Ala Val Leu Cys Cys Arg Met Ala Pro Leu Gln Lys Ala Gln
785 790 795 800
Ile Val Arg Met Val Lys Asn Leu Lys Gly Ser Pro Ile Thr Leu Ser
805 810 815
Ile Gly Asp Gly Ala Asn Asp Val Ser Met Ile Leu Glu Ser His Val
820 825 830
Gly Ile Gly Ile Lys Gly Lys Glu Gly Arg Gln Ala Ala Arg Asn Ser
835 840 845
Asp Tyr Ser Val Pro Lys Phe Lys His Leu Lys Lys Leu Leu Leu Ala
850 855 860
His Gly His Leu Tyr Tyr Val Arg Ile Ala His Leu Val Gln Tyr Phe
865 870 875 880
Phe Tyr Lys Asn Leu Cys Phe Ile Leu Pro Gln Phe Leu Tyr Gln Phe
885 890 895
Phe Cys Gly Phe Ser Gln Gln Pro Leu Tyr Asp Ala Ala Tyr Leu Thr
900 905 910
Met Tyr Asn Ile Cys Phe Thr Ser Leu Pro Ile Leu Ala Tyr Ser Leu
915 920 925
Leu Glu Gln His Ile Asn Ile Asp Thr Leu Thr Ser Asp Pro Arg Leu
930 935 940
Tyr Met Lys Ile Ser Gly Asn Ala Met Leu Gln Leu Gly Pro Phe Leu
945 950 955 960
Tyr Trp Thr Phe Leu Ala Ala Phe Glu Gly Thr Val Phe Phe Phe Gly
965 970 975
Thr Tyr Phe Leu Phe Gln Thr Ala Ser Leu Glu Glu Asn Gly Lys Val
980 985 990
Tyr Gly Asn Trp Thr Phe Gly Thr Ile Val Phe Thr Val Leu Val Phe
995 1000 1005
Thr Val Thr Leu Lys Leu Ala Leu Asp Thr Arg Phe Trp Thr Trp Ile
1010 1015 1020
Asn His Phe Val Ile Trp Gly Ser Leu Ala Phe Tyr Val Phe Phe Ser
1025 1030 1035 1040
Phe Phe Trp Gly Gly Ile Ile Trp Pro Phe Leu Lys Gln Gln Arg Met
1045 1050 1055
Tyr Phe Val Phe Ala Gln Met Leu Ser Ser Val Ser Thr Trp Leu Ala
1060 1065 1070
Ile Ile Leu Leu Ile Phe Ile Ser Leu Phe Pro Glu Ile Leu Leu Ile
1075 1080 1085
Val Leu Lys Asn Val Arg Arg Arg Ser Ala Arg Asn Pro Asn Leu Glu
1090 1095 1100
Leu Pro Met Leu Leu Ser Tyr Lys His Thr Asp Ser Gly Tyr Ser
1105 1110 1115
<210>69
<211>72
<212>PRT
<213>人
<400>69
Met Met Gln Met Phe Gly Leu Gly Ala Ile Ser Leu Ile Leu Val Cys
1 5 10 15
Leu Pro Ile Tyr Cys Arg Ser Leu Phe Trp Arg Ser Glu Pro Ala Asp
20 25 30
Asp Leu Gln Arg Gln Asp Asn Arg Val Val Thr Gly Leu Lys Lys Gln
35 40 45
Arg Arg Lys Arg Lys Arg Lys Ser Glu Met Leu Gln Lys Ala Ala Arg
50 55 60
Gly Arg Glu Glu His Gly Asp Glu
65 70
<210>70
<211>350
<212>PRT
<213>人
<400>70
Met Asn Leu Arg Gly Leu Phe Gln Asp Phe Asn Pro Ser Lys Phe Leu
1 5 10 15
Ile Tyr Ala Cys Leu Leu Leu Phe Ser Val Leu Leu Ala Leu Arg Leu
20 25 30
Asp Gly Ile Ile Gln Trp Ser Tyr Trp Ala Val Phe Ala Pro Ile Trp
35 40 45
Leu Trp Lys Leu Met Val lle Val Gly Ala Ser Val Gly Thr Gly Val
50 55 60
Trp Ala Arg Asn Pro Gln Tyr Arg Ala Glu Gly Glu Thr Cys Val Glu
65 70 75 80
Phe Lys Ala Met Leu Ile Ala Val Gly Ile His Leu Leu Leu Leu Met
85 90 95
Phe Glu Val Leu Val Cys Asp Arg Ile Glu Arg Gly Ser His Phe Trp
100 105 110
Leu Leu Val Phe Met Pro Leu Phe Phe Val Ser Pro Val Ser Val Ala
115 120 125
Ala Cys Val Trp Gly Phe Arg His Asp Arg Ser Leu Glu Leu Glu Ile
130 135 140
Leu Cys Ser Val Asn Ile Leu Gln Phe Ile Phe Ile Ala Leu Arg Leu
145 150 155 160
Asp Lys Ile Ile His Trp Pro Trp Leu Val Val Cys Val Pro Leu Trp
165 170 175
Ile Leu Met Ser Phe Leu Cys Leu Val Val Leu Tyr Tyr Ile Val Trp
180 185 190
Ser Val Leu Phe Leu Arg Ser Met Asp Val Ile Ala Glu Gln Arg Arg
195 200 205
Thr His Ile Thr Met Ala Leu Ser Trp Met Thr lle Val Val Pro Leu
210 215 220
Leu Thr Phe Glu Ile Leu Leu Val His Lys Leu Asp Gly His Asn Ala
225 230 235 240
Phe Ser Cys Ile Pro Ile Phe Val Pro Leu Trp Leu Ser Leu Ile Thr
245 250 255
Leu Met Ala Thr Thr Phe Gly Gln Lys Gly Gly Asn His Trp Trp Phe
260 265 270
Gly Ile Arg Lys Asp Phe Cys Gln Phe Leu Leu Glu Ile Phe Pro Phe
275 280 285
Leu Arg Glu Tyr Gly Asn Ile Ser Tyr Asp Leu His His Glu Asp Asn
290 295 300
Glu Glu Thr Glu Glu Thr Pro Val Pro Glu Pro Pro Lys Ile Ala Pro
305 310 315 320
Met Phe Arg Lys Lys Ala Arg Val Val Ile Thr Gln Ser Pro Gly Lys
325 330 335
Tyr Val Leu Pro Pro Pro Lys Leu Asn Ile Glu Met Pro Asp
340 345 350
<210>71
<211>156
<212>PRT
<213>人
<400>71
Met Leu Gly Ser Pro Cys Gly Pro Gln Leu Ser Asp Arg Asp Ala Asp
1 5 10 15
Glu Asp Gln Cys Ser Arg Glu Phe Arg Gly Arg Arg Ser Arg Arg Pro
20 25 30
Pro Arg Arg Thr Met Leu Arg Gly Lys Ser Arg Leu Asn Val Glu Trp
35 40 45
Leu Gly Tyr Ser Pro Gly Leu Leu Leu Glu His Arg Pro Leu Leu Ala
50 55 60
Gly Arg Thr Pro Arg Ser His Arg Arg Asn Glu Ser Ser Leu Ala Ser
65 70 75 80
Thr Leu Lys Thr Leu Leu Phe Phe Thr Ala Leu Met Ile Thr Val Pro
85 90 95
Ile Gly Leu Tyr Phe Thr Thr Lys Ser Tyr Ile Phe Glu Gly Ala Leu
100 105 110
Gly Met Ser Asn Arg Asp Ser Tyr Phe Tyr Ala Ala Ile Val Ala Val
115 120 125
Val Ala Val His Val Val Leu Ala Leu Phe Val Tyr Val Ala Trp Asn
130 135 140
Glu Gly Ser Arg Gln Trp Arg Glu Gly Lys Gln Asp
145 150 155
<210>72
<211>635
<212>PRT
<213>人
<400>72
Met Ala Lys Lys Ser Ala Glu Asn Gly Ile Tyr Ser Val Ser Gly Asp
1 5 10 15
Glu Lys Lys Gly Pro Leu Ile Ala Pro Gly Pro Asp Gly Ala Pro Ala
20 25 30
Lys Gly Asp Gly Pro Val Gly Leu Gly Thr Pro Gly Gly Arg Leu Ala
35 40 45
Val Pro Pro Arg Glu Thr Trp Thr Arg Gln Met Asp Phe Ile Met Ser
50 55 60
Cys Val Gly Phe Ala Val Gly Leu Gly Asn Val Trp Arg Phe Pro Tyr
65 70 75 80
Leu Cys Tyr Lys Asn Gly Gly Gly Val Phe Leu Ile Pro Tyr Val Leu
85 90 95
Ile Ala Leu Val Gly Gly Ile Pro Ile Phe Phe Leu Glu Ile Ser Leu
100 105 110
Gly Gln Phe Met Lys Ala Gly Ser Ile Asn Val Trp Asn Ile Cys Pro
115 120 125
Leu Phe Lys Gly Leu Gly Tyr Ala Ser Met Val Ile Val Phe Tyr Cys
130 135 140
Asn Thr Tyr Tyr Ile Met Val Leu Ala Trp Gly Phe Tyr Tyr Leu Val
145 150 155 160
Lys Ser Phe Thr Thr Thr Leu Pro Trp Ala Thr Cys Gly His Thr Trp
165 170 175
Asn Thr Pro Asp Cys Val Glu Ile Phe Arg His Glu Asp Cys Ala Asn
180 185 190
Ala Ser Leu Ala Asn Leu Thr Cys Asp Gln Leu Ala Asp Arg Arg Ser
195 200 205
Pro Val Ile Glu Phe Trp Glu Asn Lys Val Leu Arg Leu Ser Gly Gly
210 215 220
Leu Glu Val Pro Gly Ala Leu Asn Trp Glu Val Thr Leu Cys Leu Leu
225 230 235 240
Ala Cys Trp Val Leu Val Tyr Phe Cys Val Trp Lys Gly Val Lys Ser
245 250 255
Thr Gly Lys Ile Val Tyr Phe Thr Ala Thr Phe Pro Tyr Val Val Leu
260 265 270
Val Val Leu Leu Val Arg Gly Val Leu Leu Pro Gly Ala Leu Asp Gly
275 280 285
Ile Ile Tyr Tyr Leu Lys Pro Asp Trp Ser Lys Leu Gly Ser Pro Gln
290 295 300
Val Trp Ile Asp Ala Gly Thr Gln Ile Phe Phe Ser Tyr Ala Ile Gly
305 310 315 320
Leu Gly Ala Leu Thr Ala Leu Gly Ser Tyr Asn Arg Phe Asn Asn Asn
325 330 335
Cys Tyr Lys Asp Ala Ile Ile Leu Ala Leu Ile Asn Ser Gly Thr Ser
340 345 350
Phe Phe Ala Gly Phe Val Val Phe Ser Ile Leu Gly Phe Met Ala Ala
355 360 365
Glu Gln Gly Val His Ile Ser Lys Val Ala Glu Ser Gly Pro Gly Leu
370 375 380
Ala Phe Ile Ala Tyr Pro Arg Ala Val Thr Leu Met Pro Val Ala Pro
385 390 395 400
Leu Trp Ala Ala Leu Phe Phe Phe Met Leu Leu Leu Leu Gly Leu Asp
405 410 415
Ser Gln Phe Val Gly Val Glu Gly Phe Ile Thr Gly Leu Leu Asp Leu
420 425 430
Leu Pro Ala Ser Tyr Tyr Phe Arg Phe Gln Arg Glu Ile Ser Val Ala
435 440 445
Leu Cys Cys Ala Leu Cys Phe Val Ile Asp Leu Ser Met Val Thr Asp
450 455 460
Gly Gly Met Tyr Val Phe Gln Leu Phe Asp Tyr Tyr Ser Ala Ser Gly
465 470 475 480
Thr Thr Leu Leu Trp Gln Ala Phe Trp Glu Cys Val Val Val Ala Trp
485 490 495
Val Tyr Gly Ala Asp Arg Phe Met Asp Asp Ile Ala Cys Met Ile Gly
500 505 510
Tyr Arg Pro Cys Pro Trp Met Lys Trp Cys Trp Ser Phe Phe Thr Pro
515 520 525
Leu Val Cys Met Gly Ile Phe Ile Phe Asn Val Val Tyr Tyr Glu Pro
530 535 540
Leu Val Tyr Asn Asn Thr Tyr Val Tyr Pro Trp Trp Gly Glu Ala Met
545 550 555 560
Gly Trp Ala Phe Ala Leu Ser Ser Met Leu Cys Val Pro Leu His Leu
565 570 575
Leu Gly Cys Leu Leu Arg Ala Lys Gly Thr Met Ala Glu Arg Trp Gln
580 585 590
His Leu Thr Gln Pro Ile Trp Gly Leu His His Leu Glu Tyr Arg Ala
595 600 605
Gln Asp Ala Asp Val Arg Gly Leu Thr Thr Leu Thr Pro Val Ser Glu
610 615 620
Ser Ser Lys Val Val Val Val Glu Ser Val Met
625 630 635
<210>73
<211>1220
<212>PRT
<213>人
<400>73
Met Gly Asp Met Ala Asn Ser Ser Ile Glu Phe His Pro Lys Pro Gln
1 5 10 15
Gln Gln Arg Asp Val Pro Gln Ala Gly Gly Phe Gly Cys Thr Leu Ala
20 25 30
Glu Leu Arg Thr Leu Met Glu Leu Arg Gly Ala Glu Ala Leu Gln Lys
35 40 45
Ile Glu Glu Ala Tyr Gly Asp Val Ser Gly Leu Cys Arg Arg Leu Lys
50 55 60
Thr Ser Pro Thr Glu Gly Leu Ala Asp Asn Thr Asn Asp Leu Glu Lys
65 70 75 80
Arg Arg Gln Ile Tyr Gly Gln Asn Phe Ile Pro Pro Lys Gln Pro Lys
85 90 95
Thr Phe Leu Gln Leu Val Trp Glu Ala Leu Gln Asp Val Thr Leu Ile
100 105 110
Ile Leu Glu Val Ala Ala Ile Val Ser Leu Gly Leu Ser Phe Tyr Ala
115 120 125
Pro Pro Gly Glu Glu Ser Glu Ala Cys Gly Asn Val Ser Gly Gly Ala
130 135 140
Glu Asp Glu Gly Glu Ala Glu Ala Gly Trp Ile Glu Gly Ala Ala Ile
145 150 155 160
Leu Leu Ser Val Ile Cys Val Val Leu Val Thr Ala Phe Asn Asp Trp
165 170 175
Ser Lys Glu Lys Gln Phe Arg Gly Leu Gln Ser Arg Ile Glu Gln Glu
180 185 190
Gln Lys Phe Thr Val Ile Arg Asn Gly Gln Leu Leu Gln Val Pro Val
195 200 205
Ala Ala Leu Val Val Gly Asp Ile Ala Gln Val Lys Tyr Gly Asp Leu
210 215 220
Leu Pro Ala Asp Gly Val Leu Ile Gln Ala Asn Asp Leu Lys Ile Asp
225 230 235 240
Glu Ser Ser Leu Thr Gly Glu Ser Asp His Val Arg Lys Ser Ala Asp
245 250 255
Lys Asp Pro Met Leu Leu Ser Gly Thr His Val Met Glu Gly Ser Gly
260 265 270
Arg Met Val Val Thr Ala Val Gly Val Asn Ser Gln Thr Gly Ile Ile
275 280 285
Phe Thr Leu Leu Gly Ala Gly Gly Glu Glu Glu Glu Lys Lys Asp Lys
290 295 300
Lys Gly Lys Gln Gln Asp Gly Ala Met Glu Ser Ser Gln Thr Lys Ala
305 310 315 320
Lys Lys Gln Asp Gly Ala Val Ala Met Glu Met Gln Pro Leu Lys Ser
325 330 335
Ala Glu Gly Gly Glu Met Glu Glu Arg Glu Lys Lys Lys Ala Asn Ala
340 345 350
Pro Lys Lys Glu Lys Ser Val Leu Gln Gly Lys Leu Thr Lys Leu Ala
355 360 365
Val Gln Ile Gly Lys Ala Gly Leu Val Met Ser Ala Ile Thr Val Ile
370 375 380
Ile Leu Val Leu Tyr Phe Val Ile Glu Thr Phe Val Val Glu Gly Arg
385 390 395 400
Thr Trp Leu Ala Glu Cys Thr Pro Val Tyr Val Gln Tyr Phe Val Lys
405 410 415
Phe Phe Ile Ile Gly Val Thr Val Leu Val Val Ala Val Pro Glu Gly
420 425 430
Leu Pro Leu Ala Val Thr Ile Ser Leu Ala Tyr Ser Val Lys Lys Met
435 440 445
Met Lys Asp Asn Asn Leu Val Arg His Leu Asp Ala Cys Glu Thr Met
450 455 460
Gly Asn Ala Thr Ala Ile Cys Ser Asp Lys Thr Gly Thr Leu Thr Thr
465 470 475 480
Asn Arg Met Thr Val Val Gln Ser Tyr Leu Gly Asp Thr His Tyr Lys
485 490 495
Glu Ile Pro Ala Pro Ser Ala Leu Thr Pro Lys Ile Leu Asp Leu Leu
500 505 510
Val His Ala Ile Ser Ile Asn Ser Ala Tyr Thr Thr Lys Ile Leu Pro
515 520 525
Pro Glu Lys Glu Gly Ala Leu Pro Arg Gln Val Gly Asn Lys Thr Glu
530 535 540
Cys Ala Leu Leu Gly Phe Val Leu Asp Leu Lys Arg Asp Phe Gln Pro
545 550 555 560
Val Arg Glu Gln Ile Pro Glu Asp Lys Leu Tyr Lys Val Tyr Thr Phe
565 570 575
Asn Ser Val Arg Lys Ser Met Ser Thr Val Ile Arg Met Pro Asp Gly
580 585 590
Gly Phe Arg Leu Phe Ser Lys Gly Ala Ser Glu Ile Leu Leu Lys Lys
595 600 605
Cys Thr Asn Ile Leu Asn Ser Asn Gly Glu Leu Arg Gly Phe Arg Pro
610 615 620
Arg Asp Arg Asp Asp Met Val Arg Lys Ile Ile Glu Pro Met Ala Cys
625 630 635 640
Asp Gly Leu Arg Thr Ile Cys Ile Ala Tyr Arg Asp Phe Ser Ala Gly
645 650 655
Gln Glu Pro Asp Trp Asp Asn Glu Asn Glu Val Val Gly Asp Leu Thr
660 665 670
Cys Ile Ala Val Val Gly Ile Glu Asp Pro Val Arg Pro Glu Val Pro
675 680 685
Glu Ala Ile Arg Lys Cys Gln Arg Ala Gly Ile Thr Val Arg Met Val
690 695 700
Thr Gly Asp Asn Ile Asn Thr Ala Arg Ala Ile Ala Ala Lys Cys Gly
705 710 715 720
Ile Ile Gln Pro Gly Glu Asp Phe Leu Cys Leu Glu Gly Lys Glu Phe
725 730 735
Asn Arg Arg Ile Arg Asn Glu Lys Gly Glu Ile Glu Gln Glu Arg Leu
740 745 750
Asp Lys Val Trp Pro Lys Leu Arg Val Leu Ala Arg Ser Ser Pro Thr
755 760 765
Asp Lys His Thr Leu Val Lys Gly Ile Ile Asp Ser Thr Thr Gly Glu
770 775 780
Gln Arg Gln Val Val Ala Val Thr Gly Asp Gly Thr Asn Asp Gly Pro
785 790 795 800
Ala Leu Lys Lys Ala Asp Val Gly Phe Ala Met Gly Ile Ala Gly Thr
805 810 815
Asp Val Ala Lys Glu Ala Ser Asp Ile Ile Leu Thr Asp Asp Asn Phe
820 825 830
Thr Ser Ile Val Lys Ala Val Met Trp Gly Arg Asn Val Tyr Asp Ser
835 840 845
Ile Ser Lys Phe Leu Gln Phe Gln Leu Thr Val Asn Val Val Ala Val
850 855 860
Ile Val Ala Phe Thr Gly Ala Cys Ile Thr Gln Asp Ser Pro Leu Lys
865 870 875 880
Ala Val Gln Met Leu Trp Val Asn Leu Ile Met Asp Thr Phe Ala Ser
885 890 895
Leu Ala Leu Ala Thr Glu Pro Pro Thr Glu Ser Leu Leu Leu Arg Lys
900 905 910
Pro Tyr Gly Arg Asp Lys Pro Leu Ile Ser Arg Thr Met Met Lys Asn
915 920 925
Ile Leu Gly His Ala Val Tyr Gln Leu Ala Ile Ile Phe Thr Leu Leu
930 935 940
Phe Val Gly Glu Leu Phe Phe Asp Ile Asp Ser Gly Arg Asn Ala Pro
945 950 955 960
Leu His Ser Pro Pro Ser Glu His Tyr Thr Ile Ile Phe Asn Thr Phe
965 970 975
Val Met Met Gln Leu Phe Asn Glu Ile Asn Ala Arg Lys Ile His Gly
980 985 990
Glu Arg Asn Val Phe Asp Gly Ile Phe Ser Asn Pro Ile Phe Cys Thr
995 1000 1005
Ile Val Leu Gly Thr Phe Gly Ile Gln Ile Val Ile Val Gln Phe Gly
1010 1015 1020
Gly Lys Pro Phe Ser Cys Ser Pro Leu Ser Thr Glu Gln Trp Leu Trp
1025 1030 1035 1040
Cys Leu Phe Val Gly Val Gly Glu Leu Val Trp Gly Gln Val Ile Ala
1045 1050 1055
Thr Ile Pro Thr Ser Gln Leu Lys Cys Leu Lys Glu Ala Gly His Gly
1060 1065 1070
Pro Gly Lys Asp Glu Met Thr Asp Glu Glu Leu Ala Glu Gly Glu Glu
1075 1080 1085
Glu Ile Asp His Ala Glu Arg Glu Leu Arg Arg Gly Gln Ile Leu Trp
1090 1095 1100
Phe Arg Gly Leu Asn Arg Ile Gln Thr Gln Ile Arg Val Val Lys Ala
1105 1110 1115 1120
Phe Arg Ser Ser Leu Tyr Glu Gly Leu Glu Lys Pro Glu Ser Lys Thr
1125 1130 1135
Ser Ile His Asn Phe Met Ala Thr Pro Glu Phe Leu Ile Asn Asp Tyr
1140 1145 1150
Thr His Asn Ile Pro Leu Ile Asp Asp Thr Asp Val Asp Glu Asn Glu
1155 1160 1165
Glu Arg Leu Arg Ala Pro Pro Pro Pro Ser Pro Asn Gln Asn Asn Asn
1170 1175 1180
Ala Ile Asp Ser Gly Ile Tyr Leu Thr Thr His Val Thr Lys Ser Ala
1185 1190 1195 1200
Thr Ser Ser Val Phe Ser Ser Ser Pro Gly Ser Pro Leu His Ser Val
1205 1210 1215
Glu Thr Ser Leu
1220
<210>74
<211>635
<212>PRT
<213>人
<400>74
Met Ala Lys Lys Ser Ala Glu Asn Gly Ile Tyr Ser Val Ser Gly Asp
1 5 10 15
Glu Lys Lys Gly Pro Leu Ile Ala Pro Gly Pro Asp Gly Ala Pro Ala
20 25 30
Lys Gly Asp Gly Pro Val Gly Leu Gly Thr Pro Gly Gly Arg Leu Ala
35 40 45
Val Pro Pro Arg Glu Thr Trp Thr Arg Gln Met Asp Phe Ile Met Ser
50 55 60
Cys Val Gly Phe Ala Val Gly Leu Gly Asn Val Trp Arg Phe Pro Tyr
65 70 75 80
Leu Cys Tyr Lys Asn Gly Gly Gly Val Phe Leu Ile Pro Tyr Val Leu
85 90 95
Ile Ala Leu Val Gly Gly Ile Pro Ile Phe Phe Leu Glu Ile Ser Leu
100 105 110
Gly Gln Phe Met Lys Ala Gly Ser Ile Asn Val Trp Asn Ile Cys Pro
115 120 125
Leu Phe Lys Gly Leu Gly Tyr Ala Ser Met Val Ile Val Phe Tyr Cys
130 135 140
Asn Thr Tyr Tyr Ile Met Val Leu Ala Trp Gly Phe Tyr Tyr Leu Val
145 150 155 160
Lys Ser Phe Thr Thr Thr Leu Pro Trp Ala Thr Cys Gly His Thr Trp
165 170 175
Asn Thr Pro Asp Cys Val Glu Ile Phe Arg His Glu Asp Cys Ala Asn
180 185 190
Ala Ser Leu Ala Asn Leu Thr Cys Asp Gln Leu Ala Asp Arg Arg Ser
195 200 205
Pro Val Ile Glu Phe Trp Glu Asn Lys Val Leu Arg Leu Ser Gly Gly
210 215 220
Leu Glu Val Pro Gly Ala Leu Asn Trp Glu Val Thr Leu Cys Leu Leu
225 230 235 240
Ala Cys Trp Val Leu Val Tyr Phe Cys Val Trp Lys Gly Val Lys Ser
245 250 255
Thr Gly Lys Ile Val Tyr Phe Thr Ala Thr Phe Pro Tyr Val Val Leu
260 265 270
Val Val Leu Leu Val Arg Gly Val Leu Leu Pro Gly Ala Leu Asp Gly
275 280 285
Ile Ile Tyr Tyr Leu Lys Pro Asp Trp Ser Lys Leu Gly Ser Pro Gln
290 295 300
Val Trp Ile Asp Ala Gly Thr Gln Ile Phe Phe Ser Tyr Ala Ile Gly
305 310 315 320
Leu Gly Ala Leu Thr Ala Leu Gly Ser Tyr Asn Arg Phe Asn Asn Asn
325 330 335
Cys Tyr Lys Asp Ala Ile Ile Leu Ala Leu Ile Asn Ser Gly Thr Ser
340 345 350
Phe Phe Ala Gly Phe Val Val Phe Ser Ile Leu Gly Phe Met Ala Ala
355 360 365
Glu Gln Gly Val His Ile Ser Lys Val Ala Glu Ser Gly Pro Gly Leu
370 375 380
Ala Phe Ile Ala Tyr Pro Arg Ala Val Thr Leu Met Pro Val Ala Pro
385 390 395 400
Leu Trp Ala Ala Leu Phe Phe Phe Met Leu Leu Leu Leu Gly Leu Asp
405 410 415
Ser Gln Phe Val Gly Val Glu Gly Phe Ile Thr Gly Leu Leu Asp Leu
420 425 430
Leu Pro Ala Ser Tyr Tyr Phe Arg Phe Gln Arg Glu Ile Ser Val Ala
435 440 445
Leu Cys Cys Ala Leu Cys Phe Val Ile Asp Leu Ser Met Val Thr Asp
450 455 460
Gly Gly Met Tyr Val Phe Gln Leu Phe Asp Tyr Tyr Ser Ala Ser Gly
465 470 475 480
Thr Thr Leu Leu Trp Gln Ala Phe Trp Glu Cys Val Val Val Ala Trp
485 490 495
Val Tyr Gly Ala Asp Arg Phe Met Asp Asp Ile Ala Cys Met Ile Gly
500 505 510
Tyr Arg Pro Cys Pro Trp Met Lys Trp Cys Trp Ser Phe Phe Thr Pro
515 520 525
Leu Val Cys Met Gly Ile Phe Ile Phe Asn Val Val Tyr Tyr Glu Pro
530 535 540
Leu Val Tyr Asn Asn Thr Tyr Val Tyr Pro Trp Trp Gly Glu Ala Met
545 550 555 560
Gly Trp Ala Phe Ala Leu Ser Ser Met Leu Cys Val Pro Leu His Leu
565 570 575
Leu Gly Cys Leu Leu Arg Ala Lys Gly Thr Met Ala Glu Arg Trp Gln
580 585 590
His Leu Thr Gln Pro Ile Trp Gly Leu His His Leu Glu Tyr Arg Ala
595 600 605
Gln Asp Ala Asp Val Arg Gly Leu Thr Thr Leu Thr Pro Val Ser Glu
610 615 620
Ser Ser Lys Val Val Val Val Glu Ser Val Met
625 630 635
<210>75
<211>1159
<212>PRT
<213>人
<400>75
Met Gly Asp Met Ala Asn Ser Ser Ile Glu Phe His Pro Lys Pro Gln
1 5 10 15
Gln Gln Arg Asp Val Pro Gln Ala Gly Gly Phe Gly Cys Thr Leu Ala
20 25 30
Glu Leu Arg Thr Leu Met Glu Leu Arg Gly Ala Glu Ala Leu Gln Lys
35 40 45
Ile Glu Glu Ala Tyr Gly Asp Val Ser Gly Leu Cys Arg Arg Leu Lys
50 55 60
Thr Ser Pro Thr Glu Gly Leu Ala Asp Asn Thr Asn Asp Leu Glu Lys
65 70 75 80
Arg Arg Gln Ile Tyr Gly Gln Asn Phe Ile Pro Pro Lys Gln Pro Lys
85 90 95
Thr Phe Leu Gln Leu Val Trp Glu Ala Leu Gln Asp Val Thr Leu Ile
100 105 110
Ile Leu Glu Val Ala Ala Ile Val Ser Leu Gly Leu Ser Phe Tyr Ala
115 120 125
Pro Pro Gly Glu Glu Ser Glu Ala Cys Gly Asn Val Ser Gly Gly Ala
130 135 140
Glu Asp Glu Gly Glu Ala Glu Ala Gly Trp Ile Glu Gly Ala Ala Ile
145 150 155 160
Leu Leu Ser Val Ile Cys Val Val Leu Val Thr Ala Phe Asn Asp Trp
165 170 175
Ser Lys Glu Lys Gln Phe Arg Gly Leu Gln Ser Arg Ile Glu Gln Glu
180 185 190
Gln Lys Phe Thr Val Ile Arg Asn Gly Gln Leu Leu Gln Val Pro Val
195 200 205
Ala Ala Leu Val Val Gly Asp Ile Ala Gln Val Lys Tyr Gly Asp Leu
210 215 220
Leu Pro Ala Asp Gly Val Leu lle Gln Ala Asn Asp Leu Lys Ile Asp
225 230 235 240
Glu Ser Ser Leu Thr Gly Glu Ser Asp His Val Arg Lys Ser Ala Asp
245 250 255
Lys Asp Pro Met Leu Leu Ser Gly Thr His Val Met Glu Gly Ser Gly
260 265 270
Arg Met Val Val Thr Ala Val Gly Val Asn Ser Gln Thr Gly Ile Ile
275 280 285
Phe Thr Leu Leu Gly Ala Gly Gly Glu Glu Glu Glu Lys Lys Asp Lys
290 295 300
Lys Ala Lys Lys Gln Asp Gly Ala Val Ala Met Glu Met Gln Pro Leu
305 310 315 320
Lys Ser Ala Glu Gly Gly Glu Met Glu Glu Arg Glu Lys Lys Lys Ala
325 330 335
Asn Ala Pro Lys Lys Glu Lys Ser Val Leu Gln Gly Lys Leu Thr Lys
340 345 350
Leu Ala Val Gln Ile Gly Lys Ala Gly Leu Val Met Ser Ala Ile Thr
355 360 365
Val Ile Ile Leu Val Leu Tyr Phe Val Ile Glu Thr Phe Val Val Glu
370 375 380
Gly Arg Thr Trp Leu Ala Glu Cys Thr Pro Val Tyr Val Gln Tyr Phe
385 390 395 400
Val Lys Phe Phe Ile Ile Gly Val Thr Val Leu Val Val Ala Val Pro
405 410 415
Glu Gly Leu Pro Leu Ala Val Thr Ile Ser Leu Ala Tyr Ser Val Lys
420 425 430
Lys Met Met Lys Asp Asn Asn Leu Val Arg His Leu Asp Ala Cys Glu
435 440 445
Thr Met Gly Asn Ala Thr Ala Ile Cys Ser Asp Lys Thr Gly Thr Leu
450 455 460
Thr Thr Asn Arg Met Thr Val Val Gln Ser Tyr Leu Gly Asp Thr His
465 470 475 480
Tyr Lys Glu Ile Pro Ala Pro Ser Ala Leu Thr Pro Lys Ile Leu Asp
485 490 495
Leu Leu Val His Ala Ile Ser Ile Asn Ser Ala Tyr Thr Thr Lys Ile
500 505 510
Leu Pro Pro Glu Lys Glu Gly Ala Leu Pro Arg Gln Val Gly Asn Lys
515 520 525
Thr Glu Cys Ala Leu Leu Gly Phe Val Leu Asp Leu Lys Arg Asp Phe
530 535 540
Gln Pro Val Arg Glu Gln Ile Pro Glu Asp Lys Leu Tyr Lys Val Tyr
545 550 555 560
Thr Phe Asn Ser Val Arg Lys Ser Met Ser Thr Val Ile Arg Met Pro
565 570 575
Asp Gly Gly Phe Arg Leu Phe Ser Lys Gly Ala Ser Glu Ile Leu Leu
580 585 590
Lys Lys Cys Thr Asn Ile Leu Asn Ser Asn Gly Glu Leu Arg Gly Phe
595 600 605
Arg Pro Arg Asp Arg Asp Asp Met Val Arg Lys Ile Ile Glu Pro Met
610 615 620
Ala Cys Asp Gly Leu Arg Thr Ile Cys lle Ala Tyr Arg Asp Phe Ser
625 630 635 640
Ala Gly Gln Glu Pro Asp Trp Asp Asn Glu Asn Glu Val Val Gly Asp
645 650 655
Leu Thr Cys Ile Ala Val Val Gly Ile Glu Asp Pro Val Arg Pro Glu
660 665 670
Val Pro Glu Ala Ile Arg Lys Cys Gln Arg Ala Gly Ile Thr Val Arg
675 680 685
Met Val Thr Gly Asp Asn Ile Asn Thr Ala Arg Ala Ile Ala Ala Lys
690 695 700
Cys Gly Ile Ile Gln Pro Gly Glu Asp Phe Leu Cys Leu Glu Gly Lys
705 710 715 720
Glu Phe Asn Arg Arg Ile Arg Asn Glu Lys Gly Glu Ile Glu Gln Glu
725 730 735
Arg Leu Asp Lys Val Trp Pro Lys Leu Arg Val Leu Ala Arg Ser Ser
740 745 750
Pro Thr Asp Lys His Thr Leu Val Lys Gly Ile Ile Asp Ser Thr Thr
755 760 765
Gly Glu Gln Arg Gln Val Val Ala Val Thr Gly Asp Gly Thr Asn Asp
770 775 780
Gly Pro Ala Leu Lys Lys Ala Asp Val Gly Phe Ala Met Gly Ile Ala
785 790 795 800
Gly Thr Asp Val Ala Lys Glu Ala Ser Asp Ile Ile Leu Thr Asp Asp
805 810 815
Asn Phe Thr Ser Ile Val Lys Ala Val Met Trp Gly Arg Asn Val Tyr
820 825 830
Asp Ser Ile Ser Lys Phe Leu Gln Phe Gln Leu Thr Val Asn Val Val
835 840 845
Ala Val Ile Val Ala Phe Thr Gly Ala Cys Ile Thr Gln Asp Ser Pro
850 855 860
Leu Lys Ala Val Gln Met Leu Trp Val Asn Leu Ile Met Asp Thr Phe
865 870 875 880
Ala Ser Leu Ala Leu Ala Thr Glu Pro Pro Thr Glu Ser Leu Leu Leu
885 890 895
Arg Lys Pro Tyr Gly Arg Asp Lys Pro Leu Ile Ser Arg Thr Met Met
900 905 910
Lys Asn Ile Leu Gly His Ala Val Tyr Gln Leu Ala Ile Ile Phe Thr
915 920 925
Leu Leu Phe Val Gly Glu Leu Phe Phe Asp Ile Asp Ser Gly Arg Asn
930 935 940
Ala Pro Leu His Ser Pro Pro Ser Glu His Tyr Thr Ile Ile Phe Asn
945 950 955 960
Thr Phe Val Met Met Gln Leu Phe Asn Glu Ile Asn Ala Arg Lys Ile
965 970 975
His Gly Glu Arg Asn Val Phe Asp Gly Ile Phe Ser Asn Pro Ile Phe
980 985 990
Cys Thr Ile Val Leu Gly Thr Phe Gly Ile Gln Ile Val Ile Val Gln
995 1000 1005
Phe Gly Gly Lys Pro Phe Ser Cys Ser Pro Leu Ser Thr Glu Gln Trp
1010 1015 1020
Leu Trp Cys Leu Phe Val Gly Val Gly Glu Leu Val Trp Gly Gln Val
1025 1030 1035 1040
Ile Ala Thr Ile Pro Thr Ser Gln Leu Lys Cys Leu Lys Glu Ala Gly
1045 1050 1055
His Gly Pro Gly Lys Asp Glu Met Thr Asp Glu Glu Leu Ala Glu Gly
1060 1065 1070
Glu Glu Glu Ile Asp His Ala Glu Arg Glu Leu Arg Arg Gly Gln Ile
1075 1080 1085
Leu Trp Phe Arg Gly Leu Asn Arg Ile Gln Thr Gln Met Glu Val Val
1090 1095 1100
Ser Thr Phe Lys Arg Ser Gly Ser Val Gln Gly Ala Val Arg Arg Arg
1105 1110 1115 1120
Ser Ser Val Leu Ser Gln Leu His Asp Val Thr Asn Leu Ser Thr Pro
1125 1130 1135
Thr His Ala Ile Leu Ser Ala Ala Asn Pro Thr Ser Ala Ala Gly Asn
1140 1145 1150
Pro Gly Gly Glu Ser Val Pro
1155
<210>76
<211>101
<212>PRT
<213>人
<400>76
Met Glu Arg Pro Asp Lys Ala Ala Leu Asn Ala Leu Gln Pro Pro Glu
1 5 10 15
Phe Arg Asn Glu Ser Ser Leu Ala Ser Thr Leu Lys Thr Leu Leu Phe
20 25 30
Phe Thr Ala Leu Met Ile Thr Val Pro Ile Gly Leu Tyr Phe Thr Thr
35 40 45
Lys Ser Tyr Ile Phe Glu Gly Ala Leu Gly Met Ser Asn Arg Asp Ser
50 55 60
Tyr Phe Tyr Ala Ala Ile Val Ala Val Val Ala Val His Val Val Leu
65 70 75 80
Ala Leu Phe Val Tyr Val Ala Trp Asn Glu Gly Ser Arg Gln Trp Arg
85 90 95
Glu Gly Lys Gln Asp
100
<210>77
<211>728
<212>PRT
<213>人
<400>77
Met Leu Pro Thr Leu Gln Ile Gln Gly Pro Ala Ala Phe Ala Pro Gly
1 5 10 15
Asp Arg Gly Pro Gly Arg His Cys Pro Phe Pro Val Pro Ile Thr Pro
20 25 30
Thr Gly Ala Leu Leu Pro Val Ser Asp Ser Cys Asp Ser Leu Val Asp
35 40 45
Leu Val Trp Pro Ser Val Thr Tyr Leu Ala Leu Gly Thr Gln Ser Arg
50 55 60
Val Trp Pro His Pro Leu Gly Ala Pro Gly Gln Ala Gly Glu Ser Pro
65 70 75 80
Glu Gln Arg Arg Gln Cys Leu Glu Leu Trp Asp Met Ala Ser Ser Leu
85 90 95
Gly Asp Lys Val Pro Arg Ala Ala Cys Gly Lys Arg Gly Gln Thr Val
100 105 110
Trp Gln Leu His Leu Ala Cys Leu Cys Leu Ala Gln Phe His Ser Pro
115 120 125
Pro Ala Gln Pro Pro Pro Leu Ser Arg Arg Gly Gly Gly Pro Asp Pro
130 135 140
Asp Pro Ile Ser Arg Ser Leu Pro Gly Pro Pro Thr Pro Ala Leu Pro
145 150 155 160
Thr His Ser Tyr Ser Ser His Ser Pro Arg Ala Pro Arg Leu Leu Ser
165 170 175
Pro Leu Arg Arg Ala Pro Arg Gly Ser Pro Ala Pro His Arg His Ala
180 185 190
Ser Leu Gln Thr Asn Glu Ala Pro Arg Glu Leu Pro His Cys Thr Trp
195 200 205
Pro Gly Leu Pro Gly Arg Ser Leu Ala Pro Ser Phe Leu Trp Arg Glu
210 215 220
Pro Trp Leu Gly Gly Gln Trp Gly Pro Leu Asn Ile Pro Ala Arg Lys
225 230 235 240
Gly Asp Arg Arg Arg Trp Glu Trp Gly Cys Glu Gly Gly Gly Ala Thr
245 250 255
Ala Ser Ala Glu Gln Pro Pro Gln Ile Val Tyr Phe Thr Ala Thr Phe
260 265 270
Pro Tyr Val Val Leu Val Val Leu Leu Val Arg Gly Val Leu Leu Pro
275 280 285
Gly Ala Leu Asp Gly Ile Ile Tyr Tyr Leu Lys Pro Asp Trp Ser Lys
290 295 300
Leu Gly Ser Pro Gln Val Trp Ile Asp Ala Gly Thr Gln Ile Phe Phe
305 310 315 320
Ser Tyr Ala Ile Gly Leu Gly Ala Leu Thr Ala Leu Gly Ser Tyr Asn
325 330 335
Arg Phe Asn Asn Asn Cys Tyr Lys Asp Ala Ile Ile Leu Ala Leu Ile
340 345 350
Asn Ser Gly Thr Ser Phe Phe Ala Gly Phe Val Val Phe Ser Ile Leu
355 360 365
Gly Phe Met Ala Ala Glu Gln Gly Val His Ile Ser Lys Val Ala Glu
370 375 380
Ser Gly Pro Gly Leu Ala Phe Ile Ala Tyr Pro Arg Ala Val Thr Leu
385 390 395 400
Met Pro Val Ala Pro Leu Trp Ala Ala Leu Phe Phe Phe Met Leu Leu
405 410 415
Leu Leu Gly Leu Asp Ser Gln Val Cys Met Gly Leu Trp Asp Arg Glu
420 425 430
Pro Gly Gly Gly Arg Arg Glu Gly Cys Arg Gln Gly Lys Gly Trp Arg
435 440 445
Cys Gly Ala Arg Pro Glu Leu Pro Trp Pro Gln Phe Val Gly Val Glu
450 455 460
Gly Phe Ile Thr Gly Leu Leu Asp Leu Leu Pro Ala Ser Tyr Tyr Phe
465 470 475 480
Arg Phe Gln Arg Glu Ile Ser Val Ala Leu Cys Cys Ala Leu Cys Phe
485 490 495
Val Ile Asp Leu Ser Met Val Thr Asp Val Ser Gly Val Gly Gly Leu
500 505 510
Pro Val Thr Ser Gly Gly Arg Leu Pro Ser Ser Leu Thr Gly Leu Cys
515 520 525
Pro Gly Gly Met Tyr Val Phe Gln Leu Phe Asp Tyr Tyr Ser Ala Ser
530 535 540
Gly Thr Thr Leu Leu Trp Gln Ala Phe Trp Glu Cys Val Val Val Ala
545 550 555 560
Trp Val Tyr Gly Arg Ser Trp Leu Arg Ala Gly Leu Gly Asp Gly Gly
565 570 575
Gly Glu Gly Arg Ser Pro Ala Trp Pro Ser Arg Leu Thr Ser Pro Gln
580 585 590
Ala Asp Arg Phe Met Asp Asp Ile Ala Cys Met Ile Gly Tyr Arg Pro
595 600 605
Cys Pro Trp Met Lys Trp Cys Trp Ser Phe Phe Thr Pro Leu Val Cys
610 615 620
Met Gly Ile Phe Ile Phe Asn Val Val Tyr Tyr Glu Pro Leu Val Tyr
625 630 635 640
Asn Asn Thr Tyr Val Tyr Pro Trp Trp Gly Glu Ala Met Gly Trp Ala
645 650 655
Phe Ala Leu Ser Ser Met Leu Cys Val Pro Leu His Leu Leu Gly Cys
660 665 670
Leu Leu Arg Ala Lys Gly Thr Met Ala Glu Arg Trp Gln His Leu Thr
675 680 685
Gln Pro Ile Trp Gly Leu His His Leu Glu Tyr Arg Ala Gln Asp Ala
690 695 700
Asp Val Arg Gly Leu Thr Thr Leu Thr Pro Val Ser Glu Ser Ser Lys
705 710 715 720
Val Val Val Val Glu Ser Val Met
725
<210>78
<211>1108
<212>PRT
<213>人
<400>78
Met Gln Met Val Pro Ser Leu Pro Pro Ala Ser Glu Cys Ala Gly Glu
1 5 10 15
Glu Lys Arg Val Gly Thr Arg Thr Val Phe Val Gly Asn His Pro Val
20 25 30
Ser Glu Thr Glu Ala Tyr Ile Ala Gln Arg Phe Cys Asp Asn Arg Ile
35 40 45
Val Ser Ser Lys Tyr Thr Leu Trp Asn Phe Leu Pro Lys Asn Leu Phe
50 55 60
Glu Gln Phe Arg Arg Ile Ala Asn Phe Tyr Phe Leu Ile Ile Phe Leu
65 70 75 80
Val Gln Val Thr Val Asp Thr Pro Thr Ser Pro Val Thr Ser Gly Leu
85 90 95
Pro Leu Phe Phe Val Ile Thr Val Thr Ala Ile Lys Gln Gly Tyr Glu
100 105 110
Asp Cys Leu Arg His Arg Ala Asp Asn Glu Val Asn Lys Ser Thr Val
115 120 125
Tyr Ile Ile Glu Asn Ala Lys Arg Val Arg Lys Glu Ser Glu Lys Ile
130 135 140
Lys Val Gly Asp Val Val Glu Val Gln Ala Asp Glu Thr Phe Pro Cys
145 150 155 160
Asp Leu Ile Leu Leu Ser Ser Cys Thr Thr Asp Gly Thr Cys Tyr Val
165 170 175
Thr Thr Ala Ser Leu Asp Gly Glu Ser Asn Cys Lys Thr His Tyr Ala
180 185 190
Val Arg Asp Thr Ile Ala Leu Cys Thr Ala Glu Ser Ile Asp Thr Leu
195 200 205
Arg Ala Ala Ile Glu Cys Glu Gln Pro Gln Pro Asp Leu Tyr Lys Phe
210 215 220
Val Gly Arg Ile Asn Ile Tyr Ser Asn Ser Leu Glu Ala Val Ala Arg
225 230 235 240
Ser Leu Gly Pro Glu Asn Leu Leu Leu Lys Gly Ala Thr Leu Lys Asn
245 250 255
Thr Glu Lys Ile Tyr Gly Val Ala Val Tyr Thr Gly Met Glu Thr Lys
260 265 270
Met Ala Leu Asn Tyr Gln Gly Lys Ser Gln Lys Arg Ser Ala Val Glu
275 280 285
Lys Ser Ile Asn Ala Phe Leu Ile Val Tyr Leu Phe Ile Leu Leu Thr
290 295 300
Lys Ala Ala Val Cys Thr Thr Leu Lys Tyr Val Trp Gln Ser Thr Pro
305 310 315 320
Tyr Asn Asp Glu Pro Trp Tyr Asn Gln Lys Thr Gln Lys Glu Arg Glu
325 330 335
Thr Leu Lys Val Leu Lys Met Phe Thr Asp Phe Leu Ser Phe Met Val
340 345 350
Leu Phe Asn Phe Ile Ile Pro Val Ser Met Tyr Val Thr Val Glu Met
355 360 365
Gln Lys Phe Leu Gly Ser Phe Phe Ile Ser Trp Asp Lys Asp Phe Tyr
370 375 380
Asp Glu Glu Ile Asn Glu Gly Ala Leu Val Asn Thr Ser Asp Leu Asn
385 390 395 400
Glu Glu Leu Gly Gln Val Asp Tyr Val Phe Thr Asp Lys Thr Gly Thr
405 410 415
Leu Thr Glu Asn Ser Met Glu Phe Ile Glu Cys Cys Ile Asp Gly His
420 425 430
Lys Tyr Lys Gly Val Thr Gln Glu Val Asp Gly Leu Ser Gln Thr Asp
435 440 445
Gly Thr Leu Thr Tyr Phe Asp Lys Val Asp Lys Asn Arg Glu Glu Leu
450 455 460
Phe Leu Arg Ala Leu Cys Leu Cys His Thr Val Glu Ile Lys Thr Asn
465 470 475 480
Asp Ala Val Asp Gly Ala Thr Glu Ser Ala Glu Leu Thr Tyr Ile Ser
485 490 495
Ser Ser Pro Asp Glu Ile Ala Leu Val Lys Gly Ala Lys Arg Tyr Gly
500 505 510
Phe Thr Phe Leu Gly Asn Arg Asn Gly Tyr Met Arg Val Glu Asn Gln
515 520 525
Arg Lys Glu Ile Glu Glu Tyr Glu Leu Leu His Thr Leu Asn Phe Asp
530 535 540
Ala Val Arg Arg Arg Met Ser Val Ile Val Lys Thr Gln Glu Gly Asp
545 550 555 560
Ile Leu Leu Phe Cys Lys Gly Ala Asp Ser Ala Val Phe Pro Arg Val
565 570 575
Gln Asn His Glu Ile Glu Leu Thr Lys Val His Val Glu Arg Asn Ala
580 585 590
Met Asp Gly Tyr Arg Thr Leu Cys Val Ala Phe Lys Glu Ile Ala Pro
595 600 605
Asp Asp Tyr Glu Arg Ile Asn Arg Gln Leu Ile Glu Ala Lys Met Ala
610 615 620
Leu Gln Asp Arg Glu Glu Lys Met Glu Lys Val Phe Asp Asp Ile Glu
625 630 635 640
Thr Asn Met Asn Leu Ile Gly Ala Thr Ala Val Glu Asp Lys Leu Gln
645 650 655
Asp Gln Ala Ala Glu Thr Ile Glu Ala Leu His Ala Ala Gly Leu Lys
660 665 670
Val Trp Val Leu Thr Gly Asp Lys Met Glu Thr Ala Lys Ser Thr Cys
675 680 685
Tyr Ala Cys Arg Leu Phe Gln Thr Asn Thr Glu Leu Leu Glu Leu Thr
690 695 700
Thr Lys Thr Ile Glu Glu Ser Glu Arg Lys Glu Asp Arg Leu His Glu
705 710 715 720
Leu Leu Ile Glu Tyr Arg Lys Lys Leu Leu His Glu Phe Pro Lys Ser
725 730 735
Thr Arg Ser Phe Lys Lys Ala Trp Thr Glu His Gln Glu Tyr Gly Leu
740 745 750
Ile Ile Asp Gly Ser Thr Leu Ser Leu Ile Leu Asn Ser Ser Gln Asp
755 760 765
Ser Ser Ser Asn Asn Tyr Lys Ser Ile Phe Leu Gln Ile Cys Met Lys
770 775 780
Cys Thr Ala Val Leu Cys Cys Arg Met Ala Pro Leu Gln Lys Ala Gln
785 790 795 800
Ile Val Arg Met Val Lys Asn Leu Lys Gly Ser Pro Ile Thr Leu Ser
805 810 815
Ile Gly Asp Gly Ala Asn Asp Val Ser Met Ile Leu Glu Ser His Val
820 825 830
Gly Ile Gly Ile Lys Gly Lys Glu Gly Arg Gln Ala Ala Arg Asn Ser
835 840 845
Asp Tyr Ser Val Pro Lys Phe Lys His Leu Lys Lys Leu Leu Leu Ala
850 855 860
His Gly His Leu Tyr Tyr Val Arg Ile Ala His Leu Val Gln Tyr Phe
865 870 875 880
Phe Tyr Lys Asn Leu Cys Phe Ile Leu Pro Gln Phe Leu Tyr Gln Phe
885 890 895
Phe Cys Gly Phe Ser Gln Gln Pro Leu Tyr Asp Ala Ala Tyr Leu Thr
900 905 910
Met Tyr Asn Ile Cys Phe Thr Ser Leu Pro Ile Leu Ala Tyr Ser Leu
915 920 925
Leu Glu Gln His Ile Asn Ile Asp Thr Leu Thr Ser Asp Pro Arg Leu
930 935 940
Tyr Met Lys Ile Ser Gly Asn Ala Met Leu Gln Leu Gly Pro Phe Leu
945 950 955 960
Tyr Trp Thr Phe Leu Ala Ala Phe Glu Gly Thr Val Phe Phe Phe Gly
965 970 975
Thr Tyr Phe Leu Phe Gln Thr Ala Ser Leu Glu Glu Asn Gly Lys Val
980 985 990
Tyr Gly Asn Trp Thr Phe Gly Thr Ile Val Phe Thr Val Leu Val Phe
995 1000 1005
Thr Val Thr Leu Lys Leu Ala Leu Asp Thr Arg Phe Trp Thr Trp Ile
1010 1015 1020
Asn His Phe Val Ile Trp Gly Ser Leu Ala Phe Tyr Val Phe Phe Ser
1025 1030 1035 1040
Phe Phe Trp Gly Gly Ile Ile Trp Pro Phe Leu Lys Gln Gln Arg Met
1045 1050 1055
Tyr Phe Val Phe Ala Gln Met Leu Ser Ser Val Ser Thr Trp Leu Ala
1060 1065 1070
Ile Ile Leu Leu Ile Phe Ile Ser Leu Phe Pro Glu Ile Leu Leu Ile
1075 1080 1085
Val Leu Lys Asn Val Arg Arg Arg Ser Ala Arg Val His His Leu Ile
1090 1095 1100
Ser Ser Ser Ala
1105
<210>79
<211>1132
<212>PRT
<213>人
<400>79
Met Gln Met Val Pro Ser Leu Pro Pro Ala Ser Glu Cys Ala Gly Glu
1 5 10 15
Glu Lys Arg Val Gly Thr Arg Thr Val Phe Val Gly Asn His Pro Val
20 25 30
Ser Glu Thr Glu Ala Tyr Ile Ala Gln Arg Phe Cys Asp Asn Arg Ile
35 40 45
Val Ser Ser Lys Tyr Thr Leu Trp Asn Phe Leu Pro Lys Asn Leu Phe
50 55 60
Glu Gln Phe Arg Arg Ile Ala Asn Phe Tyr Phe Leu Ile Ile Phe Leu
65 70 75 80
Val Gln Val Thr Val Asp Thr Pro Thr Ser Pro Val Thr Ser Gly Leu
85 90 95
Pro Leu Phe Phe Val Ile Thr Val Thr Ala Ile Lys Gln Gly Tyr Glu
100 105 110
Asp Cys Leu Arg His Arg Ala Asp Asn Glu Val Asn Lys Ser Thr Val
115 120 125
Tyr Ile Ile Glu Asn Ala Lys Arg Val Arg Lys Glu Ser Glu Lys Ile
130 135 140
Lys Val Gly Asp Val Val Glu Val Gln Ala Asp Glu Thr Phe Pro Cys
145 150 155 160
Asp Leu Ile Leu Leu Ser Ser Cys Thr Thr Asp Gly Thr Cys Tyr Val
165 170 175
Thr Thr Ala Ser Leu Asp Gly Glu Ser Asn Cys Lys Thr His Tyr Ala
180 185 190
Val Arg Asp Thr Ile Ala Leu Cys Thr Ala Glu Ser Ile Asp Thr Leu
195 200 205
Arg Ala Ala Ile Glu Cys Glu Gln Pro Gln Pro Asp Leu Tyr Lys Phe
210 215 220
Val Gly Arg Ile Asn Ile Tyr Ser Asn Ser Leu Glu Ala Val Ala Arg
225 230 235 240
Ser Leu Gly Pro Glu Asn Leu Leu Leu Lys Gly Ala Thr Leu Lys Asn
245 250 255
Thr Glu Lys Ile Tyr Gly Val Ala Val Tyr Thr Gly Met Glu Thr Lys
260 265 270
Met Ala Leu Asn Tyr Gln Gly Lys Ser Gln Lys Arg Ser Ala Val Glu
275 280 285
Lys Ser Ile Asn Ala Phe Leu Ile Val Tyr Leu Phe Ile Leu Leu Thr
290 295 300
Lys Ala Ala Val Cys Thr Thr Leu Lys Tyr Val Trp Gln Ser Thr Pro
305 310 315 320
Tyr Asn Asp Glu Pro Trp Tyr Asn Gln Lys Thr Gln Lys Glu Arg Glu
325 330 335
Thr Leu Lys Val Leu Lys Met Phe Thr Asp Phe Leu Ser Phe Met Val
340 345 350
Leu Phe Asn Phe Ile Ile Pro Val Ser Met Tyr Val Thr Val Glu Met
355 360 365
Gln Lys Phe Leu Gly Ser Phe Phe Ile Ser Trp Asp Lys Asp Phe Tyr
370 375 380
Asp Glu Glu Ile Asn Glu Gly Ala Leu Val Asn Thr Ser Asp Leu Asn
385 390 395 400
Glu Glu Leu Gly Gln Val Asp Tyr Val Phe Thr Asp Lys Thr Gly Thr
405 410 415
Leu Thr Glu Asn Ser Met Glu Phe Ile Glu Cys Cys Ile Asp Gly His
420 425 430
Lys Tyr Lys Gly Val Thr Gln Glu Val Asp Gly Leu Ser Gln Thr Asp
435 440 445
Gly Thr Leu Thr Tyr Phe Asp Lys Val Asp Lys Asn Arg Glu Glu Leu
450 455 460
Phe Leu Arg Ala Leu Cys Leu Cys His Thr Val Glu Ile Lys Thr Asn
465 470 475 480
Asp Ala Val Asp Gly Ala Thr Glu Ser Ala Glu Leu Thr Tyr Ile Ser
485 490 495
Ser Ser Pro Asp Glu Ile Ala Leu Val Lys Gly Ala Lys Arg Tyr Gly
500 505 510
Phe Thr Phe Leu Gly Asn Arg Asn Gly Tyr Met Arg Val Glu Asn Gln
515 520 525
Arg Lys Glu Ile Glu Glu Tyr Glu Leu Leu His Thr Leu Asn Phe Asp
530 535 540
Ala Val Arg Arg Arg Met Ser Val Ile Val Lys Thr Gln Glu Gly Asp
545 550 555 560
Ile Leu Leu Phe Cys Lys Gly Ala Asp Ser Ala Val Phe Pro Arg Val
565 570 575
Gln Asn His Glu Ile Glu Leu Thr Lys Val His Val Glu Arg Asn Ala
580 585 590
Met Asp Gly Tyr Arg Thr Leu Cys Val Ala Phe Lys Glu Ile Ala Pro
595 600 605
Asp Asp Tyr Glu Arg Ile Asn Arg Gln Leu Ile Glu Ala Lys Met Ala
610 615 620
Leu Gln Asp Arg Glu Glu Lys Met Glu Lys Val Phe Asp Asp Ile Glu
625 630 635 640
Thr Asn Met Asn Leu Ile Gly Ala Thr Ala Val Glu Asp Lys Leu Gln
645 650 655
Asp Gln Ala Ala Glu Thr Ile Glu Ala Leu His Ala Ala Gly Leu Lys
660 665 670
Val Trp Val Leu Thr Gly Asp Lys Met Glu Thr Ala Lys Ser Thr Cys
675 680 685
Tyr Ala Cys Arg Leu Phe Gln Thr Asn Thr Glu Leu Leu Glu Leu Thr
690 695 700
Thr Lys Thr Ile Glu Glu Ser Glu Arg Lys Glu Asp Arg Leu His Glu
705 710 715 720
Leu Leu Ile Glu Tyr Arg Lys Lys Leu Leu His Glu Phe Pro Lys Ser
725 730 735
Thr Arg Ser Phe Lys Lys Ala Trp Thr Glu His Gln Glu Tyr Gly Leu
740 745 750
Ile Ile Asp Gly Ser Thr Leu Ser Leu Ile Leu Asn Ser Ser Gln Asp
755 760 765
Ser Ser Ser Asn Asn Tyr Lys Ser Ile Phe Leu Gln Ile Cys Met Lys
770 775 780
Cys Thr Ala Val Leu Cys Cys Arg Met Ala Pro Leu Gln Lys Ala Gln
785 790 795 800
Ile Val Arg Met Val Lys Asn Leu Lys Gly Ser Pro Ile Thr Leu Ser
805 810 815
Ile Gly Asp Gly Ala Asn Asp Val Ser Met Ile Leu Glu Ser His Val
820 825 830
Gly Ile Gly Ile Lys Gly Lys Glu Gly Arg Gln Ala Ala Arg Asn Ser
835 840 845
Asp Tyr Ser Val Pro Lys Phe Lys His Leu Lys Lys Leu Leu Leu Ala
850 855 860
His Gly His Leu Tyr Tyr Val Arg Ile Ala His Leu Val Gln Tyr Phe
865 870 875 880
Phe Tyr Lys Asn Leu Cys Phe Ile Leu Pro Gln Phe Leu Tyr Gln Phe
885 890 895
Phe Cys Gly Phe Ser Gln Gln Pro Leu Tyr Asp Ala Ala Tyr Leu Thr
900 905 910
Met Tyr Asn Ile Cys Phe Thr Ser Leu Pro Ile Leu Ala Tyr Ser Leu
915 920 925
Leu Glu Gln His Ile Asn Ile Asp Thr Leu Thr Ser Asp Pro Arg Leu
930 935 940
Tyr Met Lys Ile Ser Gly Asn Ala Met Leu Gln Leu Gly Pro Phe Leu
945 950 955 960
Tyr Trp Thr Phe Leu Ala Ala Phe Glu Gly Thr Val Phe Phe Phe Gly
965 970 975
Thr Tyr Phe Leu Phe Gln Thr Ala Ser Leu Glu Glu Asn Gly Lys Val
980 985 990
Tyr Gly Asn Trp Thr Phe Gly Thr Ile Val Phe Thr Val Leu Val Phe
995 1000 1005
Thr Val Thr Leu Lys Leu Ala Leu Asp Thr Arg Phe Trp Thr Trp Ile
1010 1015 1020
Asn His Phe Val Ile Trp Gly Ser Leu Ala Phe Tyr Val Phe Phe Ser
1025 1030 1035 1040
Phe Phe Trp Gly Gly Ile Ile Trp Pro Phe Leu Lys Gln Gln Arg Met
1045 1050 1055
Tyr Phe Val Phe Ala Gln Met Leu Ser Ser Val Ser Thr Trp Leu Ala
1060 1065 1070
Ile Ile Leu Leu Ile Phe Ile Ser Leu Phe Pro Glu Ile Leu Leu Ile
1075 1080 1085
Val Leu Lys Asn Val Arg Arg Arg Ser Ala Arg Arg Asn Leu Ser Cys
1090 1095 1100
Arg Arg Ala Ser Asp Ser Leu Ser Ala Arg Pro Ser Val Arg Pro Leu
1105 1110 1115 1120
Leu Leu Arg Thr Phe Ser Asp Glu Ser Asn Val Leu
1125 1130
<210>80
<211>1206
<212>PRT
<213>人
<400>80
Met Gly Asp Met Ala Asn Ser Ser Ile Glu Phe His Pro Lys Pro Gln
1 5 10 15
Gln Gln Arg Asp Val Pro Gln Ala Gly Gly Phe Gly Cys Thr Leu Ala
20 25 30
Glu Leu Arg Thr Leu Met Glu Leu Arg Gly Ala Glu Ala Leu Gln Lys
35 40 45
Ile Glu Glu Ala Tyr Gly Asp Val Ser Gly Leu Cys Arg Arg Leu Lys
50 55 60
Thr Ser Pro Thr Glu Gly Leu Ala Asp Asn Thr Asn Asp Leu Glu Lys
65 70 75 80
Arg Arg Gln Ile Tyr Gly Gln Asn Phe Ile Pro Pro Lys Gln Pro Lys
85 90 95
Thr Phe Leu Gln Leu Val Trp Glu Ala Leu Gln Asp Val Thr Leu Ile
100 105 110
Ile Leu Glu Val Ala Ala Ile Val Ser Leu Gly Leu Ser Phe Tyr Ala
115 120 125
Pro Pro Gly Glu Glu Ser Glu Ala Cys Gly Asn Val Ser Gly Gly Ala
130 135 140
Glu Asp Glu Gly Glu Ala Glu Ala Gly Trp Ile Glu Gly Ala Ala Ile
145 150 155 160
Leu Leu Ser Val Ile Cys Val Val Leu Val Thr Ala Phe Asn Asp Trp
165 170 175
Ser Lys Glu Lys Gln Phe Arg Gly Leu Gln Ser Arg Ile Glu Gln Glu
180 185 190
Gln Lys Phe Thr Val Ile Arg Asn Gly Gln Leu Leu Gln Val Pro Val
195 200 205
Ala Ala Leu Val Val Gly Asp Ile Ala Gln Val Lys Tyr Gly Asp Leu
210 215 220
Leu Pro Ala Asp Gly Val Leu Ile Gln Ala Asn Asp Leu Lys Ile Asp
225 230 235 240
Glu Ser Ser Leu Thr Gly Glu Ser Asp His Val Arg Lys Ser Ala Asp
245 250 255
Lys Asp Pro Met Leu Leu Ser Gly Thr His Val Met Glu Gly Ser Gly
260 265 270
Arg Met Val Val Thr Ala Val Gly Val Asn Ser Gln Thr Gly Ile Ile
275 280 285
Phe Thr Leu Leu Gly Ala Gly Gly Glu Glu Glu Glu Lys Lys Asp Lys
290 295 300
Lys Ala Lys Lys Gln Asp Gly Ala Val Ala Met Glu Met Gln Pro Leu
305 310 315 320
Lys Ser Ala Glu Gly Gly Glu Met Glu Glu Arg Glu Lys Lys Lys Ala
325 330 335
Asn Ala Pro Lys Lys Glu Lys Ser Val Leu Gln Gly Lys Leu Thr Lys
340 345 350
Leu Ala Val Gln Ile Gly Lys Ala Gly Leu Val Met Ser Ala Ile Thr
355 360 365
Val Ile Ile Leu Val Leu Tyr Phe Val Ile Glu Thr Phe Val Val Glu
370 375 380
Gly Arg Thr Trp Leu Ala Glu Cys Thr Pro Val Tyr Val Gln Tyr Phe
385 390 395 400
Val Lys Phe Phe Ile Ile Gly Val Thr Val Leu Val Val Ala Val Pro
405 410 415
Glu Gly Leu Pro Leu Ala Val Thr Ile Ser Leu Ala Tyr Ser Val Lys
420 425 430
Lys Met Met Lys Asp Asn Asn Leu Val Arg His Leu Asp Ala Cys Glu
435 440 445
Thr Met Gly Asn Ala Thr Ala Ile Cys Ser Asp Lys Thr Gly Thr Leu
450 455 460
Thr Thr Asn Arg Met Thr Val Val Gln Ser Tyr Leu Gly Asp Thr His
465 470 475 480
Tyr Lys Glu Ile Pro Ala Pro Ser Ala Leu Thr Pro Lys Ile Leu Asp
485 490 495
Leu Leu Val His Ala Ile Ser Ile Asn Ser Ala Tyr Thr Thr Lys Ile
500 505 510
Leu Pro Pro Glu Lys Glu Gly Ala Leu Pro Arg Gln Val Gly Asn Lys
515 520 525
Thr Glu Cys Ala Leu Leu Gly Phe Val Leu Asp Leu Lys Arg Asp Phe
530 535 540
Gln Pro Val Arg Glu Gln Ile Pro Glu Asp Lys Leu Tyr Lys Val Tyr
545 550 555 560
Thr Phe Asn Ser Val Arg Lys Ser Met Ser Thr Val Ile Arg Met Pro
565 570 575
Asp Gly Gly Phe Arg Leu Phe Ser Lys Gly Ala Ser Glu Ile Leu Leu
580 585 590
Lys Lys Cys Thr Asn Ile Leu Asn Ser Asn Gly Glu Leu Arg Gly Phe
595 600 605
Arg Pro Arg Asp Arg Asp Asp Met Val Arg Lys Ile Ile Glu Pro Met
610 615 620
Ala Cys Asp Gly Leu Arg Thr Ile Cys Ile Ala Tyr Arg Asp Phe Ser
625 630 635 640
Ala Gly Gln Glu Pro Asp Trp Asp Asn Glu Asn Glu Val Val Gly Asp
645 650 655
Leu Thr Cys Ile Ala Val Val Gly Ile Glu Asp Pro Val Arg Pro Glu
660 665 670
Val Pro Glu Ala Ile Arg Lys Cys Gln Arg Ala Gly Ile Thr Val Arg
675 680 685
Met Val Thr Gly Asp Asn Ile Asn Thr Ala Arg Ala Ile Ala Ala Lys
690 695 700
Cys Gly Ile Ile Gln Pro Gly Glu Asp Phe Leu Cys Leu Glu Gly Lys
705 710 715 720
Glu Phe Asn Arg Arg Ile Arg Asn Glu Lys Gly Glu Ile Glu Gln Glu
725 730 735
Arg Leu Asp Lys Val Trp Pro Lys Leu Arg Val Leu Ala Arg Ser Ser
740 745 750
Pro Thr Asp Lys His Thr Leu Val Lys Gly Ile Ile Asp Ser Thr Thr
755 760 765
Gly Glu Gln Arg Gln Val Val Ala Val Thr Gly Asp Gly Thr Asn Asp
770 775 780
Gly Pro Ala Leu Lys Lys Ala Asp Val Gly Phe Ala Met Gly Ile Ala
785 790 795 800
Gly Thr Asp Val Ala Lys Glu Ala Ser Asp Ile Ile Leu Thr Asp Asp
805 810 815
Asn Phe Thr Ser Ile Val Lys Ala Val Met Trp Gly Arg Asn Val Tyr
820 825 830
Asp Ser Ile Ser Lys Phe Leu Gln Phe Gln Leu Thr Val Asn Val Val
835 840 845
Ala Val Ile Val Ala Phe Thr Gly Ala Cys Ile Thr Gln Asp Ser Pro
850 855 860
Leu Lys Ala Val Gln Met Leu Trp Val Asn Leu Ile Met Asp Thr Phe
865 870 875 880
Ala Ser Leu Ala Leu Ala Thr Glu Pro Pro Thr Glu Ser Leu Leu Leu
885 890 895
Arg Lys Pro Tyr Gly Arg Asp Lys Pro Leu Ile Ser Arg Thr Met Met
900 905 910
Lys Asn Ile Leu Gly His Ala Val Tyr Gln Leu Ala Ile Ile Phe Thr
915 920 925
Leu Leu Phe Val Gly Glu Leu Phe Phe Asp Ile Asp Ser Gly Arg Asn
930 935 940
Ala Pro Leu His Ser Pro Pro Ser Glu His Tyr Thr Ile Ile Phe Asn
945 950 955 960
Thr Phe Val Met Met Gln Leu Phe Asn Glu Ile Asn Ala Arg Lys Ile
965 970 975
His Gly Glu Arg Asn Val Phe Asp Gly Ile Phe Ser Asn Pro Ile Phe
980 985 990
Cys Thr Ile Val Leu Gly Thr Phe Gly Ile Gln Ile Val Ile Val Gln
995 1000 1005
Phe Gly Gly Lys Pro Phe Ser Cys Ser Pro Leu Ser Thr Glu Gln Trp
1010 1015 1020
Leu Trp Cys Leu Phe Val Gly Val Gly Glu Leu Val Trp Gly Gln Val
1025 1030 1035 1040
Ile Ala Thr Ile Pro Thr Ser Gln Leu Lys Cys Leu Lys Glu Ala Gly
1045 1050 1055
His Gly Pro Gly Lys Asp Glu Met Thr Asp Glu Glu Leu Ala Glu Gly
1060 1065 1070
Glu Glu Glu Ile Asp His Ala Glu Arg Glu Leu Arg Arg Gly Gln Ile
1075 1080 1085
Leu Trp Phe Arg Gly Leu Asn Arg Ile Gln Thr Gln Ile Arg Val Val
1090 1095 1100
Lys Ala Phe Arg Ser Ser Leu Tyr Glu Gly Leu Glu Lys Pro Glu Ser
1105 1110 1115 1120
Lys Thr Ser Ile His Asn Phe Met Ala Thr Pro Glu Phe Leu Ile Asn
1125 1130 1135
Asp Tyr Thr His Asn Ile Pro Leu Ile Asp Asp Thr Asp Val Asp Glu
1140 1145 1150
Asn Glu Glu Arg Leu Arg Ala Pro Pro Pro Pro Ser Pro Asn Gln Asn
1155 1160 1165
Asn Asn Ala Ile Asp Ser Gly Ile Tyr Leu Thr Thr His Val Thr Lys
1170 1175 1180
Ser Ala Thr Ser Ser Val Phe Ser Ser Ser Pro Gly Ser Pro Leu His
1185 1190 1195 1200
Ser Val Glu Thr Ser Leu
1205
<210>81
<211>1253
<212>PRT
<213>人
<400>81
Met Val Val Ala Leu Arg Tyr Val Trp Pro Leu Leu Leu Cys Ser Pro
1 5 10 15
Cys Leu Leu Ile Gln Ile Pro Glu Glu Tyr Glu Gly His His Val Met
20 25 30
Glu Pro Pro Val Ile Thr Glu Gln Ser Pro Arg Arg Leu Val Val Phe
35 40 45
Pro Thr Asp Asp Ile Ser Leu Lys Cys Glu Ala Ser Gly Lys Pro Glu
50 55 60
Val Gln Phe Arg Trp Thr Arg Asp Gly Val His Phe Lys Pro Lys Glu
65 70 75 80
Glu Leu Gly Val Thr Val Tyr Gln Ser Pro His Ser Gly Ser Phe Thr
85 90 95
Ile Thr Gly Asn Asn Ser Asn Phe Ala Gln Arg Phe Gln Gly Ile Tyr
100 105 110
Arg Cys Phe Ala Ser Asn Lys Leu Gly Thr Ala Met Ser His Glu Ile
115 120 125
Arg Leu Met Ala Glu Gly Ala Pro Lys Trp Pro Lys Glu Thr Val Lys
130 135 140
Pro Val Glu Val Glu Glu Gly Glu Ser Val Val Leu Pro Cys Asn Pro
145 150 155 160
Pro Pro Ser Ala Glu Pro Leu Arg Ile Tyr Trp Met Asn Ser Lys Ile
165 170 175
Leu His Ile Lys Gln Asp Glu Arg Val Thr Met Gly Gln Asn Gly Asn
180 185 190
Leu Tyr Phe Ala Asn Val Leu Thr Ser Asp Asn His Ser Asp Tyr Ile
195 200 205
Cys His Ala His Phe Pro Gly Thr Arg Thr Ile Ile Gln Lys Glu Pro
210 215 220
Ile Asp Leu Arg Val Lys Ala Thr Asn Ser Met Ile Asp Arg Lys Pro
225 230 235 240
Arg Leu Leu Phe Pro Thr Asn Ser Ser Ser His Leu Val Ala Leu Gln
245 250 255
Gly Gln Pro Leu Val Leu Glu Cys Ile Ala Glu Gly Phe Pro Thr Pro
260 265 270
Thr Ile Lys Trp Leu Arg Pro Ser Gly Pro Met Pro Ala Asp Arg Val
275 280 285
Thr Tyr Gln Asn His Asn Lys Thr Leu Gln Leu Leu Lys Val Gly Glu
290 295 300
Glu Asp Asp Gly Glu Tyr Arg Cys Leu Ala Glu Asn Ser Leu Gly Ser
305 310 315 320
Ala Arg His Ala Tyr Tyr Val Thr Val Glu Ala Ala Pro Tyr Trp Leu
325 330 335
His Lys Pro Gln Ser His Leu Tyr Gly Pro Gly Glu Thr Ala Arg Leu
340 345 350
Asp Cys Gln Val Gln Gly Arg Pro Gln Pro Glu Val Thr Trp Arg Ile
355 360 365
Asn Gly Ile Pro Val Glu Glu Leu Ala Lys Asp Gln Lys Tyr Arg Ile
370 375 380
Gln Arg Gly Ala Leu Ile Leu Ser Asn Val Gln Pro Ser Asp Thr Met
385 390 395 400
Val Thr Gln Cys Glu Ala Arg Asn Arg His Gly Leu Leu Leu Ala Asn
405 410 415
Ala Tyr Ile Tyr Val Val Gln Leu Pro Ala Lys Ile Leu Thr Ala Asp
420 425 430
Asn Gln Thr Tyr Met Ala Val Gln Gly Ser Thr Ala Tyr Leu Leu Cys
435 440 445
Lys Ala Phe Gly Ala Pro Val Pro Ser Val Gln Trp Leu Asp Glu Asp
450 455 460
Gly Thr Thr Val Leu Gln Asp Glu Arg Phe Phe Pro Tyr Ala Asn Gly
465 470 475 480
Thr Leu Gly Ile Arg Asp Leu Gln Ala Asn Asp Thr Gly Arg Tyr Phe
485 490 495
Cys Leu Ala Ala Asn Asp Gln Asn Asn Val Thr Ile Met Ala Asn Leu
500 505 510
Lys Val Lys Asp Ala Thr Gln Ile Thr Gln Gly Pro Arg Ser Thr Ile
515 520 525
Glu Lys Lys Gly Ser Arg Val Thr Phe Thr Cys Gln Ala Ser Phe Asp
530 535 540
Pro Ser Leu Gln Pro Ser Ile Thr Trp Arg Gly Asp Gly Arg Asp Leu
545 550 555 560
Gln Glu Leu Gly Asp Ser Asp Lys Tyr Phe Ile Glu Asp Gly Arg Leu
565 570 575
Val Ile His Ser Leu Asp Tyr Ser Asp Gln Gly Asn Tyr Ser Cys Val
580 585 590
Ala Ser Thr Glu Leu Asp Val Val Glu Ser Arg Ala Gln Leu Leu Val
595 600 605
Val Gly Ser Pro Gly Pro Val Pro Arg Leu Val Leu Ser Asp Leu His
610 615 620
Leu Leu Thr Gln Ser Gln Val Arg Val Ser Trp Ser Pro Ala Glu Asp
625 630 635 640
His Asn Ala Pro Ile Glu Lys Tyr Asp Ile Glu Phe Glu Asp Lys Glu
645 650 655
Met Ala Pro Glu Lys Trp Tyr Ser Leu Gly Lys Val Pro Gly Asn Gln
660 665 670
Thr Ser Thr Thr Leu Lys Leu Ser Pro Tyr Val His Tyr Thr Phe Arg
675 680 685
Val Thr Ala Ile Asn Lys Tyr Gly Pro Gly Glu Pro Ser Pro Val Ser
690 695 700
Glu Thr Val Val Thr Pro Glu Ala Ala Pro Glu Lys Asn Pro Val Asp
705 710 715 720
Val Lys Gly Glu Gly Asn Glu Thr Thr Asn Met Val Ile Thr Trp Lys
725 730 735
Pro Leu Arg Trp Met Asp Trp Asn Ala Pro Gln Val Gln Tyr Arg Val
740 745 750
Gln Trp Arg Pro Gln Gly Thr Arg Gly Pro Trp Gln Glu Gln Ile Val
755 760 765
Ser Asp Pro Phe Leu Val Val Ser Asn Thr Ser Thr Phe Val Pro Tyr
770 775 780
Glu Ile Lys Val Gln Ala Val Asn Ser Gln Gly Lys Gly Pro Glu Pro
785 790 795 800
Gln Val Thr Ile Gly Tyr Ser Gly Glu Asp Tyr Pro Gln Ala Ile Pro
805 810 815
Glu Leu Glu Gly Ile Glu Ile Leu Asn Ser Ser Ala Val Leu Val Lys
820 825 830
Trp Arg Pro Val Asp Leu Ala Gln Val Lys Gly His Leu Arg Gly Tyr
835 840 845
Asn Val Thr Tyr Trp Arg Glu Gly Ser Gln Arg Lys His Ser Lys Arg
850 855 860
His Ile His Lys Asp His Val Val Val Pro Ala Asn Thr Thr Ser Val
865 870 875 880
Ile Leu Ser Gly Leu Arg Pro Tyr Ser Ser Tyr His Leu Glu Val Gln
885 890 895
Ala Phe Asn Gly Arg Gly Ser Gly Pro Ala Ser Glu Phe Thr Phe Ser
900 905 910
Thr Pro Glu Gly Val Pro Gly His Pro Glu Ala Leu His Leu Glu Cys
915 920 925
Gln Ser Asn Thr Ser Leu Leu Leu Arg Trp Gln Pro Pro Leu Ser His
930 935 940
Asn Gly Val Leu Thr Gly Tyr Val Leu Ser Tyr His Pro Leu Asp Glu
945 950 955 960
Gly Gly Lys Gly Gln Leu Ser Phe Asn Leu Arg Asp Pro Glu Leu Arg
965 970 975
Thr His Asn Leu Thr Asp Leu Ser Pro His Leu Arg Tyr Arg Phe Gln
980 985 990
Leu Gln Ala Thr Thr Lys Glu Gly Pro Gly Glu Ala Ile Val Arg Glu
995 1000 1005
Gly Gly Thr Met Ala Leu Ser Gly Ile Ser Asp Phe Gly Asn Ile Ser
1010 1015 1020
Ala Thr Ala Gly Glu Asn Tyr Ser Val Val Ser Trp Val Pro Lys Glu
1025 1030 1035 1040
Gly Gln Cys Asn Phe Arg Phe His Ile Leu Phe Lys Ala Leu Gly Glu
1045 1050 1055
Glu Lys Gly Gly Ala Ser Leu Ser Pro Gln Tyr Val Ser Tyr Asn Gln
1060 1065 1070
Ser Ser Tyr Thr Gln Trp Asp Leu Gln Pro Asp Thr Asp Tyr Glu Ile
1075 1080 1085
His Leu Phe Lys Glu Arg Met Phe Arg His Gln Met Ala Val Lys Thr
1090 1095 1100
Asn Gly Thr Gly Arg Val Arg Leu Pro Pro Ala Gly Phe Ala Thr Glu
1105 1110 1115 1120
Gly Trp Phe Ile Gly Phe Val Ser Ala Ile Ile Leu Leu Leu Leu Val
1125 1130 1135
Leu Leu Ile Leu Cys Phe Ile Lys Arg Ser Lys Gly Gly Lys Tyr Ser
1140 1145 1150
Val Lys Asp Lys Glu Asp Thr Gln Val Asp Ser Glu Ala Arg Pro Met
1155 1160 1165
Lys Asp Glu Thr Phe Gly Glu Tyr Ser Asp Asn Glu Glu Lys Ala Phe
1170 1175 1180
Gly Ser Ser Gln Pro Ser Leu Asn Gly Asp Ile Lys Pro Leu Gly Ser
1185 1190 1195 1200
Asp Asp Ser Leu Ala Asp Tyr Gly Gly Ser Val Asp Val Gln Phe Asn
1205 1210 1215
Glu Asp Gly Ser Phe Ile Gly Gln Tyr Ser Gly Lys Lys Glu Lys Glu
1220 1225 1230
Ala Ala Gly Gly Asn Asp Ser Ser Gly Ala Thr Ser Pro Ile Asn Pro
1235 1240 1245
Ala Val Ala Leu Glu
1250
<210>82
<211>1257
<212>PRT
<213>人
<400>82
Met Val Val Ala Leu Arg Tyr Val Trp Pro Leu Leu Leu Cys Ser Pro
1 5 10 15
Cys Leu Leu Ile Gln Ile Pro Glu Glu Tyr Glu Gly His His Val Met
20 25 30
Glu Pro Pro Val Ile Thr Glu Gln Ser Pro Arg Arg Leu Val Val Phe
35 40 45
Pro Thr Asp Asp Ile Ser Leu Lys Cys Glu Ala Ser Gly Lys Pro Glu
50 55 60
Val Gln Phe Arg Trp Thr Arg Asp Gly Val His Phe Lys Pro Lys Glu
65 70 75 80
Glu Leu Gly Val Thr Val Tyr Gln Ser Pro His Ser Gly Ser Phe Thr
85 90 95
Ile Thr Gly Asn Asn Ser Asn Phe Ala Gln Arg Phe Gln Gly Ile Tyr
100 105 110
Arg Cys Phe Ala Ser Asn Lys Leu Gly Thr Ala Met Ser His Glu Ile
115 120 125
Arg Leu Met Ala Glu Gly Ala Pro Lys Trp Pro Lys Glu Thr Val Lys
130 135 140
Pro Val Glu Val Glu Glu Gly Glu Ser Val Val Leu Pro Cys Asn Pro
145 150 155 160
Pro Pro Ser Ala Glu Pro Leu Arg Ile Tyr Trp Met Asn Ser Lys Ile
165 170 175
Leu His Ile Lys Gln Asp Glu Arg Val Thr Met Gly Gln Asn Gly Asn
180 185 190
Leu Tyr Phe Ala Asn Val Leu Thr Ser Asp Asn His Ser Asp Tyr Ile
195 200 205
Cys His Ala His Phe Pro Gly Thr Arg Thr Ile Ile Gln Lys Glu Pro
210 215 220
Ile Asp Leu Arg Val Lys Ala Thr Asn Ser Met Ile Asp Arg Lys Pro
225 230 235 240
Arg Leu Leu Phe Pro Thr Asn Ser Ser Ser His Leu Val Ala Leu Gln
245 250 255
Gly Gln Pro Leu Val Leu Glu Cys Ile Ala Glu Gly Phe Pro Thr Pro
260 265 270
Thr Ile Lys Trp Leu Arg Pro Ser Gly Pro Met Pro Ala Asp Arg Val
275 280 285
Thr Tyr Gln Asn His Asn Lys Thr Leu Gln Leu Leu Lys Val Gly Glu
290 295 300
Glu Asp Asp Gly Glu Tyr Arg Cys Leu Ala Glu Asn Ser Leu Gly Ser
305 310 315 320
Ala Arg His Ala Tyr Tyr Val Thr Val Glu Ala Ala Pro Tyr Trp Leu
325 330 335
His Lys Pro Gln Ser His Leu Tyr Gly Pro Gly Glu Thr Ala Arg Leu
340 345 350
Asp Cys Gln Val Gln Gly Arg Pro Gln Pro Glu Val Thr Trp Arg Ile
355 360 365
Asn Gly Ile Pro Val Glu Glu Leu Ala Lys Asp Gln Lys Tyr Arg Ile
370 375 380
Gln Arg Gly Ala Leu Ile Leu Ser Asn Val Gln Pro Ser Asp Thr Met
385 390 395 400
Val Thr Gln Cys Glu Ala Arg Asn Arg His Gly Leu Leu Leu Ala Asn
405 410 415
Ala Tyr Ile Tyr Val Val Gln Leu Pro Ala Lys Ile Leu Thr Ala Asp
420 425 430
Asn Gln Thr Tyr Met Ala Val Gln Gly Ser Thr Ala Tyr Leu Leu Cys
435 440 445
Lys Ala Phe Gly Ala Pro Val Pro Ser Val Gln Trp Leu Asp Glu Asp
450 455 460
Gly Thr Thr Val Leu Gln Asp Glu Arg Phe Phe Pro Tyr Ala Asn Gly
465 470 475 480
Thr Leu Gly Ile Arg Asp Leu Gln Ala Asn Asp Thr Gly Arg Tyr Phe
485 490 495
Cys Leu Ala Ala Asn Asp Gln Asn Asn Val Thr Ile Met Ala Asn Leu
500 505 510
Lys Val Lys Asp Ala Thr Gln Ile Thr Gln Gly Pro Arg Ser Thr Ile
515 520 525
Glu Lys Lys Gly Ser Arg Val Thr Phe Thr Cys Gln Ala Ser Phe Asp
530 535 540
Pro Ser Leu Gln Pro Ser Ile Thr Trp Arg Gly Asp Gly Arg Asp Leu
545 550 555 560
Gln Glu Leu Gly Asp Ser Asp Lys Tyr Phe Ile Glu Asp Gly Arg Leu
565 570 575
Val Ile His Ser Leu Asp Tyr Ser Asp Gln Gly Asn Tyr Ser Cys Val
580 585 590
Ala Ser Thr Glu Leu Asp Val Val Glu Ser Arg Ala Gln Leu Leu Val
595 600 605
Val Gly Ser Pro Gly Pro Val Pro Arg Leu Val Leu Ser Asp Leu His
610 615 620
Leu Leu Thr Gln Ser Gln Val Arg Val Ser Trp Ser Pro Ala Glu Asp
625 630 635 640
His Asn Ala Pro Ile Glu Lys Tyr Asp Ile Glu Phe Glu Asp Lys Glu
645 650 655
Met Ala Pro Glu Lys Trp Tyr Ser Leu Gly Lys Val Pro Gly Asn Gln
660 665 670
Thr Ser Thr Thr Leu Lys Leu Ser Pro Tyr Val His Tyr Thr Phe Arg
675 680 685
Val Thr Ala Ile Asn Lys Tyr Gly Pro Gly Glu Pro Ser Pro Val Ser
690 695 700
Glu Thr Val Val Thr Pro Glu Ala Ala Pro Glu Lys Asn Pro Val Asp
705 710 715 720
Val Lys Gly Glu Gly Asn Glu Thr Thr Asn Met Val Ile Thr Trp Lys
725 730 735
Pro Leu Arg Trp Met Asp Trp Asn Ala Pro Gln Val Gln Tyr Arg Val
740 745 750
Gln Trp Arg Pro Gln Gly Thr Arg Gly Pro Trp Gln Glu Gln Ile Val
755 760 765
Ser Asp Pro Phe Leu Val Val Ser Asn Thr Ser Thr Phe Val Pro Tyr
770 775 780
Glu Ile Lys Val Gln Ala Val Asn Ser Gln Gly Lys Gly Pro Glu Pro
785 790 795 800
Gln Val Thr Ile Gly Tyr Ser Gly Glu Asp Tyr Pro Gln Ala Ile Pro
805 810 815
Glu Leu Glu Gly Ile Glu Ile Leu Asn Ser Ser Ala Val Leu Val Lys
820 825 830
Trp Arg Pro Val Asp Leu Ala Gln Val Lys Gly His Leu Arg Gly Tyr
835 840 845
Asn Val Thr Tyr Trp Arg Glu Gly Ser Gln Arg Lys His Ser Lys Arg
850 855 860
His Ile His Lys Asp His Val Val Val Pro Ala Asn Thr Thr Ser Val
865 870 875 880
Ile Leu Ser Gly Leu Arg Pro Tyr Ser Ser Tyr His Leu Glu Val Gln
885 890 895
Ala Phe Asn Gly Arg Gly Ser Gly Pro Ala Ser Glu Phe Thr Phe Ser
900 905 910
Thr Pro Glu Gly Val Pro Gly His Pro Glu Ala Leu His Leu Glu Cys
915 920 925
Gln Ser Asn Thr Ser Leu Leu Leu Arg Trp Gln Pro Pro Leu Ser His
930 935 940
Asn Gly Val Leu Thr Gly Tyr Val Leu Ser Tyr His Pro Leu Asp Glu
945 950 955 960
Gly Gly Lys Gly Gln Leu Ser Phe Asn Leu Arg Asp Pro Glu Leu Arg
965 970 975
Thr His Asn Leu Thr Asp Leu Ser Pro His Leu Arg Tyr Arg Phe Gln
980 985 990
Leu Gln Ala Thr Thr Lys Glu Gly Pro Gly Glu Ala Ile Val Arg Glu
995 1000 1005
Gly Gly Thr Met Ala Leu Ser Gly Ile Ser Asp Phe Gly Asn Ile Ser
1010 1015 1020
Ala Thr Ala Gly Glu Asn Tyr Ser Val Val Ser Trp Val Pro Lys Glu
1025 1030 1035 1040
Gly Gln Cys Asn Phe Arg Phe His Ile Leu Phe Lys Ala Leu Gly Glu
1045 1050 1055
Glu Lys Gly Gly Ala Ser Leu Ser Pro Gln Tyr Val Ser Tyr Asn Gln
1060 1065 1070
Ser Ser Tyr Thr Gln Trp Asp Leu Gln Pro Asp Thr Asp Tyr Glu Ile
1075 1080 1085
His Leu Phe Lys Glu Arg Met Phe Arg His Gln Met Ala Val Lys Thr
1090 1095 1100
Asn Gly Thr Gly Arg Val Arg Leu Pro Pro Ala Gly Phe Ala Thr Glu
1105 1110 1115 1120
Gly Trp Phe Ile Gly Phe Val Ser Ala Ile Ile Leu Leu Leu Leu Val
1125 1130 1135
Leu Leu Ile Leu Cys Phe Ile Lys Arg Ser Lys Gly Gly Lys Tyr Ser
1140 1145 1150
Val Lys Asp Lys Glu Asp Thr Gln Val Asp Ser Glu Ala Arg Pro Met
1155 1160 1165
Lys Asp Glu Thr Phe Gly Glu Tyr Arg Ser Leu Glu Ser Asp Asn Glu
1170 1175 1180
Glu Lys Ala Phe Gly Ser Ser Gln Pro Ser Leu Asn Gly Asp Ile Lys
1185 1190 1195 1200
Pro Leu Gly Ser Asp Asp Ser Leu Ala Asp Tyr Gly Gly Ser Val Asp
1205 1210 1215
Val Gln Phe Asn Glu Asp Gly Ser Phe Ile Gly Gln Tyr Ser Gly Lys
1220 1225 1230
Lys Glu Lys Glu Ala Ala Gly Gly Asn Asp Ser Ser Gly Ala Thr Ser
1235 1240 1245
Pro Ile Asn Pro Ala Val Ala Leu Glu
1250 1255
<210>83
<211>1253
<212>PRT
<213>人
<400>83
Met Val Val Ala Leu Arg Tyr Val Trp Pro Leu Leu Leu Cys Ser Pro
1 5 10 15
Cys Leu Leu Ile Gln Ile Pro Glu Glu Tyr Glu Gly His His Val Met
20 25 30
Glu Pro Pro Val Ile Thr Glu Gln Ser Pro Arg Arg Leu Val Val Phe
35 40 45
Pro Thr Asp Asp Ile Ser Leu Lys Cys Glu Ala Ser Gly Lys Pro Glu
50 55 60
Val Gln Phe Arg Trp Thr Arg Asp Gly Val His Phe Lys Pro Lys Glu
65 70 75 80
Glu Leu Gly Val Thr Val Tyr Gln Ser Pro His Ser Gly Ser Phe Thr
85 90 95
Ile Thr Gly Asn Asn Ser Asn Phe Ala Gln Arg Phe Gln Gly Ile Tyr
100 105 110
Arg Cys Phe Ala Ser Asn Lys Leu Gly Thr Ala Met Ser His Glu Ile
115 120 125
Arg Leu Met Ala Glu Gly Ala Pro Lys Trp Pro Lys Glu Thr Val Lys
130 135 140
Pro Val Glu Val Glu Glu Gly Glu Ser Val Val Leu Pro Cys Asn Pro
145 150 155 160
Pro Pro Ser Ala Glu Pro Leu Arg Ile Tyr Trp Met Asn Ser Lys Ile
165 170 175
Leu His Ile Lys Gln Asp Glu Arg Val Thr Met Gly Gln Asn Gly Asn
180 185 190
Leu Tyr Phe Ala Asn Val Leu Thr Ser Asp Asn His Ser Asp Tyr Ile
195 200 205
Cys His Ala His Phe Pro Gly Thr Arg Thr Ile Ile Gln Lys Glu Pro
210 215 220
Ile Asp Leu Arg Val Lys Ala Thr Asn Ser Met Ile Asp Arg Lys Pro
225 230 235 240
Arg Leu Leu Phe Pro Thr Asn Ser Ser Ser His Leu Val Ala Leu Gln
245 250 255
Gly Gln Pro Leu Val Leu Glu Cys Ile Ala Glu Gly Phe Pro Thr Pro
260 265 270
Thr Ile Lys Trp Leu Arg Pro Ser Gly Pro Met Pro Ala Asp Arg Val
275 280 285
Thr Tyr Gln Asn His Asn Lys Thr Leu Gln Leu Leu Lys Val Gly Glu
290 295 300
Glu Asp Asp Gly Glu Tyr Arg Cys Leu Ala Glu Asn Ser Leu Gly Ser
305 310 315 320
Ala Arg His Ala Tyr Tyr Val Thr Val Glu Ala Ala Pro Tyr Trp Leu
325 330 335
His Lys Pro Gln Ser His Leu Tyr Gly Pro Gly Glu Thr Ala Arg Leu
340 345 350
Asp Cys Gln Val Gln Gly Arg Pro Gln Pro Glu Val Thr Trp Arg Ile
355 360 365
Asn Gly Ile Pro Val Glu Glu Leu Ala Lys Asp Gln Lys Tyr Arg Ile
370 375 380
Gln Arg Gly Ala Leu Ile Leu Ser Asn Val Gln Pro Ser Asp Thr Met
385 390 395 400
Val Thr Gln Cys Glu Ala Arg Asn Arg His Gly Leu Leu Leu Ala Asn
405 410 415
Ala Tyr Ile Tyr Val Val Gln Leu Pro Ala Lys Ile Leu Thr Ala Asp
420 425 430
Asn Gln Thr Tyr Met Ala Val Gln Gly Ser Thr Ala Tyr Leu Leu Cys
435 440 445
Lys Ala Phe Gly Ala Pro Val Pro Ser Val Gln Trp Leu Asp Glu Asp
450 455 460
Gly Thr Thr Val Leu Gln Asp Glu Arg Phe Phe Pro Tyr Ala Asn Gly
465 470 475 480
Thr Leu Gly Ile Arg Asp Leu Gln Ala Asn Asp Thr Gly Arg Tyr Phe
485 490 495
Cys Leu Ala Ala Asn Asp Gln Asn Asn Val Thr Ile Met Ala Asn Leu
500 505 510
Lys Val Lys Asp Ala Thr Gln Ile Thr Gln Gly Pro Arg Ser Thr Ile
515 520 525
Glu Lys Lys Gly Ser Arg Val Thr Phe Thr Cys Gln Ala Ser Phe Asp
530 535 540
Pro Ser Leu Gln Pro Ser Ile Thr Trp Arg Gly Asp Gly Arg Asp Leu
545 550 555 560
Gln Glu Leu Gly Asp Ser Asp Lys Tyr Phe Ile Glu Asp Gly Arg Leu
565 570 575
Val Ile His Ser Leu Asp Tyr Ser Asp Gln Gly Asn Tyr Ser Cys Val
580 585 590
Ala Ser Thr Glu Leu Asp Val Val Glu Ser Arg Ala Gln Leu Leu Val
595 600 605
Val Gly Asn Pro Gly Pro Val Pro Arg Leu Val Leu Ser Asp Leu His
610 615 620
Leu Leu Thr Gln Ser Gln Val Arg Val Ser Trp Ser Pro Ala Glu Asp
625 630 635 640
His Asn Ala Pro Ile Glu Lys Tyr Asp Ile Glu Phe Glu Asp Lys Glu
645 650 655
Met Ala Pro Glu Lys Trp Tyr Ser Leu Gly Lys Val Pro Gly Asn Gln
660 665 670
Thr Ser Thr Thr Leu Lys Leu Ser Pro Tyr Val His Tyr Thr Phe Arg
675 680 685
Val Thr Ala Ile Asn Lys Tyr Gly Pro Gly Glu Pro Ser Pro Val Ser
690 695 700
Glu Thr Val Val Thr Pro Glu Ala Ala Pro Glu Lys Asn Pro Val Asp
705 710 715 720
Val Lys Gly Glu Gly Asn Glu Thr Thr Asn Met Val Ile Thr Trp Lys
725 730 735
Pro Leu Arg Trp Met Asp Trp Asn Ala Pro Gln Val Gln Tyr Arg Val
740 745 750
Gln Trp Arg Pro Gln Gly Thr Arg Gly Pro Trp Gln Glu Gln Ile Val
755 760 765
Ser Asp Pro Phe Leu Val Val Ser Asn Thr Ser Thr Phe Val Pro Tyr
770 775 780
Glu Ile Lys Val Gln Ala Val Asn Ser Gln Gly Lys Gly Pro Glu Pro
785 790 795 800
Gln Val Thr Ile Gly Tyr Ser Gly Glu Asp Tyr Pro Gln Ala Ile Pro
805 810 815
Glu Leu Glu Gly Ile Glu Ile Leu Asn Ser Ser Ala Val Leu Val Lys
820 825 830
Trp Arg Pro Val Asp Leu Ala Gln Val Lys Gly His Leu Arg Gly Tyr
835 840 845
Asn Val Thr Tyr Trp Arg Glu Gly Ser Gln Arg Lys His Ser Lys Arg
850 855 860
His Ile His Lys Asp His Val Val Val Pro Ala Asn Thr Thr Ser Val
865 870 875 880
Ile Leu Ser Gly Leu Arg Pro Tyr Ser Ser Tyr His Leu Glu Val Gln
885 890 895
Ala Phe Asn Gly Arg Gly Ser Gly Pro Ala Ser Glu Phe Thr Phe Ser
900 905 910
Thr Pro Glu Gly Val Pro Gly His Pro Glu Ala Leu His Leu Glu Cys
915 920 925
Gln Ser Asn Thr Ser Leu Leu Leu Arg Trp Gln Pro Pro Leu Ser His
930 935 940
Asn Gly Val Leu Thr Gly Tyr Val Leu Ser Tyr His Pro Leu Asp Glu
945 950 955 960
Gly Gly Lys Gly Gln Leu Ser Phe Asn Leu Arg Asp Pro Glu Leu Arg
965 970 975
Thr His Asn Leu Thr Asp Leu Ser Pro His Leu Arg Tyr Arg Phe Gln
980 985 990
Leu Gln Ala Thr Thr Lys Glu Gly Pro Gly Glu Ala Ile Val Arg Glu
995 1000 1005
Gly Gly Thr Met Ala Leu Ser Gly Ile Ser Asp Phe Gly Asn Ile Ser
1010 1015 1020
Ala Thr Ala Gly Glu Asn Tyr Ser Val Val Ser Trp Val Pro Lys Glu
1025 1030 1035 1040
Gly Gln Cys Asn Phe Arg Phe His Ile Leu Phe Lys Ala Leu Gly Glu
1045 1050 1055
Glu Lys Gly Gly Ala Ser Leu Ser Pro Gln Tyr Val Ser Tyr Asn Gln
1060 1065 1070
Ser Ser Tyr Thr Gln Trp Asp Leu Gln Pro Asp Thr Asp Tyr Glu Ile
1075 1080 1085
His Leu Phe Lys Glu Arg Met Phe Arg His Gln Met Ala Val Lys Thr
1090 1095 1100
Asn Gly Thr Gly Arg Val Arg Leu Pro Pro Ala Gly Phe Ala Thr Glu
1105 1110 1115 1120
Gly Trp Phe Ile Gly Phe Val Ser Ala Ile Ile Leu Leu Leu Leu Val
1125 1130 1135
Leu Leu Ile Leu Cys Phe Ile Lys Arg Ser Lys Gly Gly Lys Tyr Ser
1140 1145 1150
Val Lys Asp Lys Glu Asp Thr Gln Val Asp Ser Glu Ala Arg Pro Met
1155 1160 1165
Lys Asp Glu Thr Phe Gly Glu Tyr Ser Asp Asn Glu Glu Lys Ala Phe
1170 1175 1180
Gly Ser Ser Gln Pro Ser Leu Asn Gly Asp Ile Lys Pro Leu Gly Ser
1185 1190 1195 1200
Asp Asp Ser Leu Ala Asp Tyr Gly Gly Ser Val Asp Val Gln Phe Asn
1205 1210 1215
Glu Asp Gly Ser Phe Ile Gly Gln Tyr Ser Gly Lys Lys Glu Lys Glu
1220 1225 1230
Ala Ala Gly Gly Asn Asp Ser Ser Gly Ala Thr Ser Pro Ile Asn Pro
1235 1240 1245
Ala Val Ala Leu Glu
1250
<210>84
<211>1220
<212>PRT
<213>人
<400>84
Met Gly Asp Met Ala Asn Ser Ser Ile Glu Phe His Pro Lys Pro Gln
1 5 10 15
Gln Gln Arg Asp Val Pro Gln Ala Gly Gly Phe Gly Cys Thr Leu Ala
20 25 30
Glu Leu Arg Thr Leu Met Glu Leu Arg Gly Ala Glu Ala Leu Gln Lys
35 40 45
Ile Glu Glu Ala Tyr Gly Asp Val Ser Gly Leu Cys Arg Arg Leu Lys
50 55 60
Thr Ser Pro Thr Glu Gly Leu Ala Asp Asn Thr Asn Asp Leu Glu Lys
65 70 75 80
Arg Arg Gln Ile Tyr Gly Gln Asn Phe Ile Pro Pro Lys Gln Pro Lys
85 90 95
Thr Phe Leu Gln Leu Val Trp Glu Ala Leu Gln Asp Val Thr Leu Ile
100 105 110
Ile Leu Glu Val Ala Ala Ile Val Ser Leu Gly Leu Ser Phe Tyr Ala
115 120 125
Pro Pro Gly Glu Glu Ser Glu Ala Cys Gly Asn Val Ser Gly Gly Ala
130 135 140
Glu Asp Glu Gly Glu Ala Glu Ala Gly Trp Ile Glu Gly Ala Ala Ile
145 150 155 160
Leu Leu Ser Val Ile Cys Val Val Leu Val Thr Ala Phe Asn Asp Trp
165 170 175
Ser Lys Glu Lys Gln Phe Arg Gly Leu Gln Ser Arg Ile Glu Gln Glu
180 185 190
Gln Lys Phe Thr Val Ile Arg Asn Gly Gln Leu Leu Gln Val Pro Val
195 200 205
Ala Ala Leu Val Val Gly Asp Ile Ala Gln Val Lys Tyr Gly Asp Leu
210 215 220
Leu Pro Ala Asp Gly Val Leu Ile Gln Ala Asn Asp Leu Lys Ile Asp
225 230 235 240
Glu Ser Ser Leu Thr Gly Glu Ser Asp His Val Arg Lys Ser Ala Asp
245 250 255
Lys Asp Pro Met Leu Leu Ser Gly Thr His Val Met Glu Gly Ser Gly
260 265 270
Arg Met Val Val Thr Ala Val Gly Val Asn Ser Gln Thr Gly Ile Ile
275 280 285
Phe Thr Leu Leu Gly Ala Gly Gly Glu Glu Glu Glu Lys Lys Asp Lys
290 295 300
Lys Gly Lys Gln Gln Asp Gly Ala Met Glu Ser Ser Gln Thr Lys Ala
305 310 315 320
Lys Lys Gln Asp Gly Ala Val Ala Met Glu Met Gln Pro Leu Lys Ser
325 330 335
Ala Glu Gly Gly Glu Met Glu Glu Arg Glu Lys Lys Lys Ala Asn Ala
340 345 350
Pro Lys Lys Glu Lys Ser Val Leu Gln Gly Lys Leu Thr Lys Leu Ala
355 360 365
Val Gln Ile Gly Lys Ala Gly Leu Val Met Ser Ala Ile Thr Val Ile
370 375 380
Ile Leu Val Leu Tyr Phe Val Ile Glu Thr Phe Val Val Glu Gly Arg
385 390 395 400
Thr Trp Leu Ala Glu Cys Thr Pro Val Tyr Val Gln Tyr Phe Val Lys
405 410 415
Phe Phe Ile Ile Gly Val Thr Val Leu Val Val Ala Val Pro Glu Gly
420 425 430
Leu Pro Leu Ala Val Thr Ile Ser Leu Ala Tyr Ser Val Lys Lys Met
435 440 445
Met Lys Asp Asn Asn Leu Val Arg His Leu Asp Ala Cys Glu Thr Met
450 455 460
Gly Asn Ala Thr Ala Ile Cys Ser Asp Lys Thr Gly Thr Leu Thr Thr
465 470 475 480
Asn Arg Met Thr Val Val Gln Ser Tyr Leu Gly Asp Thr His Tyr Lys
485 490 495
Glu Ile Pro Ala Pro Ser Ala Leu Thr Pro Lys Ile Leu Asp Leu Leu
500 505 510
Val His Ala Ile Ser Ile Asn Ser Ala Tyr Thr Thr Lys Ile Leu Pro
515 520 525
Pro Glu Lys Glu Gly Ala Leu Pro Arg Gln Val Gly Asn Lys Thr Glu
530 535 540
Cys Ala Leu Leu Gly Phe Val Leu Asp Leu Lys Arg Asp Phe Gln Pro
545 550 555 560
Val Arg Glu Gln Ile Pro Glu Asp Lys Leu Tyr Lys Val Tyr Thr Phe
565 570 575
Asn Ser Val Arg Lys Ser Met Ser Thr Val Ile Arg Met Pro Asp Gly
580 585 590
Gly Phe Arg Leu Phe Ser Lys Gly Ala Ser Glu Ile Leu Leu Lys Lys
595 600 605
Cys Thr Asn Ile Leu Asn Ser Asn Gly Glu Leu Arg Gly Phe Arg Pro
610 615 620
Arg Asp Arg Asp Asp Met Val Arg Lys Ile Ile Glu Pro Met Ala Cys
625 630 635 640
Asp Gly Leu Arg Thr Ile Cys Ile Ala Tyr Arg Asp Phe Ser Ala Gly
645 650 655
Gln Glu Pro Asp Trp Asp Asn Glu Asn Glu Val Val Gly Asp Leu Thr
660 665 670
Cys Ile Ala Val Val Gly Ile Glu Asp Pro Val Arg Pro Glu Val Pro
675 680 685
Glu Ala Ile Arg Lys Cys Gln Arg Ala Gly Ile Thr Val Arg Met Val
690 695 700
Thr Gly Asp Asn Ile Asn Thr Ala Arg Ala Ile Ala Ala Lys Cys Gly
705 710 715 720
Ile Ile Gln Pro Gly Glu Asp Phe Leu Cys Leu Glu Gly Lys Glu Phe
725 730 735
Asn Arg Arg Ile Arg Asn Glu Lys Gly Glu Ile Glu Gln Glu Arg Leu
740 745 750
Asp Lys Val Trp Pro Lys Leu Arg Val Leu Ala Arg Ser Ser Pro Thr
755 760 765
Asp Lys His Thr Leu Val Lys Gly Ile Ile Asp Ser Thr Thr Gly Glu
770 775 780
Gln Arg Gln Val Val Ala Val Thr Gly Asp Gly Thr Asn Asp Gly Pro
785 790 795 800
Ala Leu Lys Lys Ala Asp Val Gly Phe Ala Met Gly Ile Ala Gly Thr
805 810 815
Asp Val Ala Lys Glu Ala Ser Asp Ile Ile Leu Thr Asp Asp Asn Phe
820 825 830
Thr Ser Ile Val Lys Ala Val Met Trp Gly Arg Asn Val Tyr Asp Ser
835 840 845
Ile Ser Lys Phe Leu Gln Phe Gln Leu Thr Val Asn Val Val Ala Val
850 855 860
Ile Val Ala Phe Thr Gly Ala Cys Ile Thr Gln Asp Ser Pro Leu Lys
865 870 875 880
Ala Val Gln Met Leu Trp Val Asn Leu Ile Met Asp Thr Phe Ala Ser
885 890 895
Leu Ala Leu Ala Thr Glu Pro Pro Thr Glu Ser Leu Leu Leu Arg Lys
900 905 910
Pro Tyr Gly Arg Asp Lys Pro Leu Ile Ser Arg Thr Met Met Lys Asn
915 920 925
Ile Leu Gly His Ala Val Tyr Gln Leu Ala Ile Ile Phe Thr Leu Leu
930 935 940
Phe Val Gly Glu Leu Phe Phe Asp Ile Asp Ser Gly Arg Asn Ala Pro
945 950 955 960
Leu His Ser Pro Pro Ser Glu His Tyr Thr Ile Ile Phe Asn Thr Phe
965 970 975
Val Met Met Gln Leu Phe Asn Glu Ile Asn Ala Arg Lys Ile His Gly
980 985 990
Glu Arg Asn Val Phe Asp Gly Ile Phe Ser Asn Pro Ile Phe Cys Thr
995 1000 1005
Ile Val Leu Gly Thr Phe Gly Ile Gln Ile Val Ile Val Gln Phe Gly
1010 1015 1020
Gly Lys Pro Phe Ser Cys Ser Pro Leu Ser Thr Glu Gln Trp Leu Trp
1025 1030 1035 1040
Cys Leu Phe Val Gly Val Gly Glu Leu Val Trp Gly Gln Val Ile Ala
1045 1050 1055
Thr Ile Pro Thr Ser Gln Leu Lys Cys Leu Lys Glu Ala Gly His Gly
1060 1065 1070
Pro Gly Lys Asp Glu Met Thr Asp Glu Glu Leu Ala Glu Gly Glu Glu
1075 1080 1085
Glu Ile Asp His Ala Glu Arg Glu Leu Arg Arg Gly Gln Ile Leu Trp
1090 1095 1100
Phe Arg Gly Leu Asn Arg Ile Gln Thr Gln Ile Arg Val Val Lys Ala
1105 1110 1115 1120
Phe Arg Ser Ser Leu Tyr Glu Gly Leu Glu Lys Pro Glu Ser Lys Thr
1125 1130 1135
Ser Ile His Asn Phe Met Ala Thr Pro Glu Phe Leu Ile Asn Asp Tyr
1140 1145 1150
Thr His Asn Ile Pro Leu Ile Asp Asp Thr Asp Val Asp Glu Asn Glu
1155 1160 1165
Glu Arg Leu Arg Ala Pro Pro Pro Pro Ser Pro Asn Gln Asn Asn Asn
1170 1175 1180
Ala Ile Asp Ser Gly Ile Tyr Leu Thr Thr His Val Thr Lys Ser Ala
1185 1190 1195 1200
Thr Ser Ser Val Phe Ser Ser Ser Pro Gly Ser Pro Leu His Ser Val
1205 1210 1215
Glu Thr Ser Leu
1220
<210>85
<211>1257
<212>PRT
<213>人
<400>85
Met Val Val Ala Leu Arg Tyr Val Trp Pro Leu Leu Leu Cys Ser Pro
1 5 10 15
Cys Leu Leu Ile Gln Ile Pro Glu Glu Tyr Glu Gly His His Val Met
20 25 30
Glu Pro Pro Val Ile Thr Glu Gln Ser Pro Arg Arg Leu Val Val Phe
35 40 45
Pro Thr Asp Asp Ile Ser Leu Lys Cys Glu Ala Ser Gly Lys Pro Glu
50 55 60
Val Gln Phe Arg Trp Thr Arg Asp Gly Val His Phe Lys Pro Lys Glu
65 70 75 80
Glu Leu Gly Val Thr Val Tyr Gln Ser Pro His Ser Gly Ser Phe Thr
85 90 95
Ile Thr Gly Asn Asn Ser Asn Phe Ala Gln Arg Phe Gln Gly Ile Tyr
100 105 110
Arg Cys Phe Ala Ser Asn Lys Leu Gly Thr Ala Met Ser His Glu Ile
115 120 125
Arg Leu Met Ala Glu Gly Ala Pro Lys Trp Pro Lys Glu Thr Val Lys
130 135 140
Pro Val Glu Val Glu Glu Gly Glu Ser Val Val Leu Pro Cys Asn Pro
145 150 155 160
Pro Pro Ser Ala Glu Pro Leu Arg Ile Tyr Trp Met Asn Ser Lys Ile
165 170 175
Leu His Ile Lys Gln Asp Glu Arg Val Thr Met Gly Gln Asn Gly Asn
180 185 190
Leu Tyr Phe Ala Asn Val Leu Thr Ser Asp Asn His Ser Asp Tyr Ile
195 200 205
Cys His Ala His Phe Pro Gly Thr Arg Thr Ile Ile Gln Lys Glu Pro
210 215 220
Ile Asp Leu Arg Val Lys Ala Thr Asn Ser Met Ile Asp Arg Lys Pro
225 230 235 240
Arg Leu Leu Phe Pro Thr Asn Ser Ser Ser His Leu Val Ala Leu Gln
245 250 255
Gly Gln Pro Leu Val Leu Glu Cys Ile Ala Glu Gly Phe Pro Thr Pro
260 265 270
Thr Ile Lys Trp Leu Arg Pro Ser Gly Pro Met Pro Ala Asp Arg Val
275 280 285
Thr Tyr Gln Asn His Asn Lys Thr Leu Gln Leu Leu Lys Val Gly Glu
290 295 300
Glu Asp Asp Gly Glu Tyr Arg Cys Leu Ala Glu Asn Ser Leu Gly Ser
305 310 315 320
Ala Arg His Ala Tyr Tyr Val Thr Val Glu Ala Ala Pro Tyr Trp Leu
325 330 335
His Lys Pro Gln Ser His Leu Tyr Gly Pro Gly Glu Thr Ala Arg Leu
340 345 350
Asp Cys Gln Val Gln Gly Arg Pro Gln Pro Glu Val Thr Trp Arg Ile
355 360 365
Asn Gly Ile Pro Val Glu Glu Leu Ala Lys Asp Gln Lys Tyr Arg Ile
370 375 380
Gln Arg Gly Ala Leu Ile Leu Ser Asn Val Gln Pro Ser Asp Thr Met
385 390 395 400
Val Thr Gln Cys Glu Ala Arg Asn Arg His Gly Leu Leu Leu Ala Asn
405 410 415
Ala Tyr Ile Tyr Val Val Gln Leu Pro Ala Lys Ile Leu Thr Ala Asp
420 425 430
Asn Gln Thr Tyr Met Ala Val Gln Gly Ser Thr Ala Tyr Leu Leu Cys
435 440 445
Lys Ala Phe Gly Ala Pro Val Pro Ser Val Gln Trp Leu Asp Glu Asp
450 455 460
Gly Thr Thr Val Leu Gln Asp Glu Arg Phe Phe Pro Tyr Ala Asn Gly
465 470 475 480
Thr Leu Gly Ile Arg Asp Leu Gln Ala Asn Asp Thr Gly Arg Tyr Phe
485 490 495
Cys Leu Ala Ala Asn Asp Gln Asn Asn Val Thr Ile Met Ala Asn Leu
500 505 510
Lys Val Lys Asp Ala Thr Gln Ile Thr Gln Gly Pro Arg Ser Thr Ile
515 520 525
Glu Lys Lys Gly Ser Arg Val Thr Phe Thr Cys Gln Ala Ser Phe Asp
530 535 540
Pro Ser Leu Gln Pro Ser Ile Thr Trp Arg Gly Asp Gly Arg Asp Leu
545 550 555 560
Gln Glu Leu Gly Asp Ser Asp Lys Tyr Phe Ile Glu Asp Gly Arg Leu
565 570 575
Val Ile His Ser Leu Asp Tyr Ser Asp Gln Gly Asn Tyr Ser Cys Val
580 585 590
Ala Ser Thr Glu Leu Asp Val Val Glu Ser Arg Ala Gln Leu Leu Val
595 600 605
Val Gly Ser Pro Gly Pro Val Pro Arg Leu Val Leu Ser Asp Leu His
610 615 620
Leu Leu Thr Gln Ser Gln Val Arg Val Ser Trp Ser Pro Ala Glu Asp
625 630 635 640
His Asn Ala Pro Ile Glu Lys Tyr Asp Ile Glu Phe Glu Asp Lys Glu
645 650 655
Met Ala Pro Glu Lys Trp Tyr Ser Leu Gly Lys Val Pro Gly Asn Gln
660 665 670
Thr Ser Thr Thr Leu Lys Leu Ser Pro Tyr Val His Tyr Thr Phe Arg
675 680 685
Val Thr Ala Ile Asn Lys Tyr Gly Pro Gly Glu Pro Ser Pro Val Ser
690 695 700
Glu Thr Val Val Thr Pro Glu Ala Ala Pro Glu Lys Asn Pro Val Asp
705 710 715 720
Val Lys Gly Glu Gly Asn Glu Thr Thr Asn Met Val Ile Thr Trp Lys
725 730 735
Pro Leu Arg Trp Met Asp Trp Asn Ala Pro Gln Val Gln Tyr Arg Val
740 745 750
Gln Trp Arg Pro Gln Gly Thr Arg Gly Pro Trp Gln Glu Gln Ile Val
755 760 765
Ser Asp Pro Phe Leu Val Val Ser Asn Thr Ser Thr Phe Val Pro Tyr
770 775 780
Glu Ile Lys Val Gln Ala Val Asn Ser Gln Gly Lys Gly Pro Glu Pro
785 790 795 800
Gln Val Thr Ile Gly Tyr Ser Gly Glu Asp Tyr Pro Gln Ala Ile Pro
805 810 815
Glu Leu Glu Gly Ile Glu Ile Leu Asn Ser Ser Ala Val Leu Val Lys
820 825 830
Trp Arg Pro Val Asp Leu Ala Gln Val Lys Gly His Leu Arg Gly Tyr
835 840 845
Asn Val Thr Tyr Trp Arg Glu Gly Ser Gln Arg Lys His Ser Lys Arg
850 855 860
His Ile His Lys Asp His Val Val Val Pro Ala Asn Thr Thr Ser Val
865 870 875 880
Ile Leu Ser Gly Leu Arg Pro Tyr Ser Ser Tyr His Leu Glu Val Gln
885 890 895
Ala Phe Asn Gly Arg Gly Ser Gly Pro Ala Ser Glu Phe Thr Phe Ser
900 905 910
Thr Pro Glu Gly Val Pro Gly His Pro Glu Ala Leu His Leu Glu Cys
915 920 925
Gln Ser Asn Thr Ser Leu Leu Leu Arg Trp Gln Pro Pro Leu Ser His
930 935 940
Asn Gly Val Leu Thr Gly Tyr Val Leu Ser Tyr His Pro Leu Asp Glu
945 950 955 960
Gly Gly Lys Gly Gln Leu Ser Phe Asn Leu Arg Asp Pro Glu Leu Arg
965 970 975
Thr His Asn Leu Thr Asp Leu Ser Pro His Leu Arg Tyr Arg Phe Gln
980 985 990
Leu Gln Ala Thr Thr Lys Glu Gly Pro Gly Glu Ala Ile Val Arg Glu
995 1000 1005
Gly Gly Thr Met Ala Leu Ser Gly Ile Ser Asp Phe Gly Asn Ile Ser
1010 1015 1020
Ala Thr Ala Gly Glu Asn Tyr Ser Val Val Ser Trp Val Pro Lys Glu
1025 1030 1035 1040
Gly Gln Cys Asn Phe Arg Phe His Ile Leu Phe Lys Ala Leu Gly Glu
1045 1050 1055
Glu Lys Gly Gly Ala Ser Leu Ser Pro Gln Tyr Val Ser Tyr Asn Gln
1060 1065 1070
Ser Ser Tyr Thr Gln Trp Asp Leu Gln Pro Asp Thr Asp Tyr Glu Ile
1075 1080 1085
His Leu Phe Lys Glu Arg Met Phe Arg His Gln Met Ala Val Lys Thr
1090 1095 1100
Asn Gly Thr Gly Arg Val Arg Leu Pro Pro Ala Gly Phe Ala Thr Glu
1105 1110 1115 1120
Gly Trp Phe Ile Gly Phe Val Ser Ala Ile Ile Leu Leu Leu Leu Val
1125 1130 1135
Leu Leu Ile Leu Cys Phe Ile Lys Arg Ser Lys Gly Gly Lys Tyr Ser
1140 1145 1150
Val Lys Asp Lys Glu Asp Thr Gln Val Asp Ser Glu Ala Arg Pro Met
1155 1160 1165
Lys Asp Glu Thr Phe Gly Glu Tyr Arg Ser Leu Glu Ser Asp Asn Glu
1170 1175 1180
Glu Lys Ala Phe Gly Ser Ser Gln Pro Ser Leu Asn Gly Asp Ile Lys
1185 1190 1195 1200
Pro Leu Gly Ser Asp Asp Ser Leu Ala Asp Tyr Gly Gly Ser Val Asp
1205 1210 1215
Val Gln Phe Asn Glu Asp Gly Ser Phe Ile Gly Gln Tyr Ser Gly Lys
1220 1225 1230
Lys Glu Lys Glu Ala Ala Gly Gly Asn Asp Ser Ser Gly Ala Thr Ser
1235 1240 1245
Pro Ile Asn Pro Ala Val Ala Leu Glu
1250 1255
<210>86
<211>1173
<212>PRT
<213>人
<400>86
Met Gly Asp Met Ala Asn Ser Ser Ile Glu Phe His Pro Lys Pro Gln
1 5 10 15
Gln Gln Arg Asp Val Pro Gln Ala Gly Gly Phe Gly Cys Thr Leu Ala
20 25 30
Glu Leu Arg Thr Leu Met Glu Leu Arg Gly Ala Glu Ala Leu Gln Lys
35 40 45
Ile Glu Glu Ala Tyr Gly Asp Val Ser Gly Leu Cys Arg Arg Leu Lys
50 55 60
Thr Ser Pro Thr Glu Gly Leu Ala Asp Asn Thr Asn Asp Leu Glu Lys
65 70 75 80
Arg Arg Gln Ile Tyr Gly Gln Asn Phe Ile Pro Pro Lys Gln Pro Lys
85 90 95
Thr Phe Leu Gln Leu Val Trp Glu Ala Leu Gln Asp Val Thr Leu Ile
100 105 110
Ile Leu Glu Val Ala Ala Ile Val Ser Leu Gly Leu Ser Phe Tyr Ala
115 120 125
Pro Pro Gly Glu Glu Ser Glu Ala Cys Gly Asn Val Ser Gly Gly Ala
130 135 140
Glu Asp Glu Gly Glu Ala Glu Ala Gly Trp Ile Glu Gly Ala Ala Ile
145 150 155 160
Leu Leu Ser Val Ile Cys Val Val Leu Val Thr Ala Phe Asn Asp Trp
165 170 175
Ser Lys Glu Lys Gln Phe Arg Gly Leu Gln Ser Arg Tle Glu Gln Glu
180 185 190
Gln Lys Phe Thr Val Ile Arg Asn Gly Gln Leu Leu Gln Val Pro Val
195 200 205
Ala Ala Leu Val Val Gly Asp Ile Ala Gln Val Lys Tyr Gly Asp Leu
210 215 220
Leu Pro Ala Asp Gly Val Leu Ile Gln Ala Asn Asp Leu Lys Ile Asp
225 230 235 240
Glu Ser Ser Leu Thr Gly Glu Ser Asp His Val Arg Lys Ser Ala Asp
245 250 255
Lys Asp Pro Met Leu Leu Ser Gly Thr His Val Met Glu Gly Ser Gly
260 265 270
Arg Met Val Val Thr Ala Val Gly Val Asn Ser Gln Thr Gly Ile Ile
275 280 285
Phe Thr Leu Leu Gly Ala Gly Gly Glu Glu Glu Glu Lys Lys Asp Lys
290 295 300
Lys Gly Lys Gln Gln Asp Gly Ala Met Glu Ser Ser Gln Thr Lys Ala
305 310 315 320
Lys Lys Gln Asp Gly Ala Val Ala Met Glu Met Gln Pro Leu Lys Ser
325 330 335
Ala Glu Gly Gly Glu Met Glu Glu Arg Glu Lys Lys Lys Ala Asn Ala
340 345 350
Pro Lys Lys Glu Lys Ser Val Leu Gln Gly Lys Leu Thr Lys Leu Ala
355 360 365
Val Gln Ile Gly Lys Ala Gly Leu Val Met Ser Ala Ile Thr Val Ile
370 375 380
Ile Leu Val Leu Tyr Phe Val Ile Glu Thr Phe Val Val Glu Gly Arg
385 390 395 400
Thr Trp Leu Ala Glu Cys Thr Pro Val Tyr Val Gln Tyr Phe Val Lys
405 410 415
Phe Phe Ile Ile Gly Val Thr Val Leu Val Val Ala Val Pro Glu Gly
420 425 430
Leu Pro Leu Ala Val Thr Ile Ser Leu Ala Tyr Ser Val Lys Lys Met
435 440 445
Met Lys Asp Asn Asn Leu Val Arg His Leu Asp Ala Cys Glu Thr Met
450 455 460
Gly Asn Ala Thr Ala Ile Cys Ser Asp Lys Thr Gly Thr Leu Thr Thr
465 470 475 480
Asn Arg Met Thr Val Val Gln Ser Tyr Leu Gly Asp Thr His Tyr Lys
485 490 495
Glu Ile Pro Ala Pro Ser Ala Leu Thr Pro Lys Ile Leu Asp Leu Leu
500 505 510
Val His Ala Ile Ser Ile Asn Ser Ala Tyr Thr Thr Lys Ile Leu Pro
515 520 525
Pro Glu Lys Glu Gly Ala Leu Pro Arg Gln Val Gly Asn Lys Thr Glu
530 535 540
Cys Ala Leu Leu Gly Phe Val Leu Asp Leu Lys Arg Asp Phe Gln Pro
545 550 555 560
Val Arg Glu Gln Ile Pro Glu Asp Lys Leu Tyr Lys Val Tyr Thr Phe
565 570 575
Asn Ser Val Arg Lys Ser Met Ser Thr Val Ile Arg Met Pro Asp Gly
580 585 590
Gly Phe Arg Leu Phe Ser Lys Gly Ala Ser Glu Ile Leu Leu Lys Lys
595 600 605
Cys Thr Asn Ile Leu Asn Ser Asn Gly Glu Leu Arg Gly Phe Arg Pro
610 615 620
Arg Asp Arg Asp Asp Met Val Arg Lys Ile Ile Glu Pro Met Ala Cys
625 630 635 640
Asp Gly Leu Arg Thr Ile Cys Ile Ala Tyr Arg Asp Phe Ser Ala Gly
645 650 655
Gln Glu Pro Asp Trp Asp Asn Glu Asn Glu Val Val Gly Asp Leu Thr
660 665 670
Cys Ile Ala Val Val Gly Ile Glu Asp Pro Val Arg Pro Glu Val Pro
675 680 685
Glu Ala Ile Arg Lys Cys Gln Arg Ala Gly Ile Thr Val Arg Met Val
690 695 700
Thr Gly Asp Asn Ile Asn Thr Ala Arg Ala Ile Ala Ala Lys Cys Gly
705 710 715 720
Ile Ile Gln Pro Gly Glu Asp Phe Leu Cys Leu Glu Gly Lys Glu Phe
725 730 735
Asn Arg Arg Ile Arg Asn Glu Lys Gly Glu Ile Glu Gln Glu Arg Leu
740 745 750
Asp Lys Val Trp Pro Lys Leu Arg Val Leu Ala Arg Ser Ser Pro Thr
755 760 765
Asp Lys His Thr Leu Val Lys Gly Ile Ile Asp Ser Thr Thr Gly Glu
770 775 780
Gln Arg Gln Val Val Ala Val Thr Gly Asp Gly Thr Asn Asp Gly Pro
785 790 795 800
Ala Leu Lys Lys Ala Asp Val Gly Phe Ala Met Gly Ile Ala Gly Thr
805 810 815
Asp Val Ala Lys Glu Ala Ser Asp Ile Ile Leu Thr Asp Asp Asn Phe
820 825 830
Thr Ser Ile Val Lys Ala Val Met Trp Gly Arg Asn Val Tyr Asp Ser
835 840 845
Ile Ser Lys Phe Leu Gln Phe Gln Leu Thr Val Asn Val Val Ala Val
850 855 860
Ile Val Ala Phe Thr Gly Ala Cys Ile Thr Gln Asp Ser Pro Leu Lys
865 870 875 880
Ala Val Gln Met Leu Trp Val Asn Leu Ile Met Asp Thr Phe Ala Ser
885 890 895
Leu Ala Leu Ala Thr Glu Pro Pro Thr Glu Ser Leu Leu Leu Arg Lys
900 905 910
Pro Tyr Gly Arg Asp Lys Pro Leu Ile Ser Arg Thr Met Met Lys Asn
915 920 925
Ile Leu Gly His Ala Val Tyr Gln Leu Ala Ile Ile Phe Thr Leu Leu
930 935 940
Phe Val Gly Glu Leu Phe Phe Asp Ile Asp Ser Gly Arg Asn Ala Pro
945 950 955 960
Leu His Ser Pro Pro Ser Glu His Tyr Thr Ile Ile Phe Asn Thr Phe
965 970 975
Val Met Met Gln Leu Phe Asn Glu Ile Asn Ala Arg Lys Ile His Gly
980 985 990
Glu Arg Asn Val Phe Asp Gly Ile Phe Ser Asn Pro Ile Phe Cys Thr
995 1000 1005
Ile Val Leu Gly Thr Phe Gly Ile Gln Ile Val Ile Val Gln Phe Gly
1010 1015 1020
Gly Lys Pro Phe Ser Cys Ser Pro Leu Ser Thr Glu Gln Trp Leu Trp
1025 1030 1035 1040
Cys Leu Phe Val Gly Val Gly Glu Leu Val Trp Gly Gln Val Ile Ala
1045 1050 1055
Thr Ile Pro Thr Ser Gln Leu Lys Cys Leu Lys Glu Ala Gly His Gly
1060 1065 1070
Pro Gly Lys Asp Glu Met Thr Asp Glu Glu Leu Ala Glu Gly Glu Glu
1075 1080 1085
Glu Ile Asp His Ala Glu Arg Glu Leu Arg Arg Gly Gln Ile Leu Trp
1090 1095 1100
Phe Arg Gly Leu Asn Arg Ile Gln Thr Gln Met Glu Val Val Ser Thr
1105 1110 1115 1120
Phe Lys Arg Ser Gly Ser Val Gln Gly Ala Val Arg Arg Arg Ser Ser
1125 1130 1135
Val Leu Ser Gln Leu His Asp Val Thr Asn Leu Ser Thr Pro Thr His
1140 1145 1150
Ala Ile Leu Ser Ala Ala Asn Pro Thr Ser Ala Ala Gly Asn Pro Gly
1155 1160 1165
Gly Glu Ser Val Pro
1170
<210>87
<211>1257
<212>PRT
<213>人
<400>87
Met Val Val Ala Leu Arg Tyr Val Trp Pro Leu Leu Leu Cys Ser Pro
1 5 10 15
Cys Leu Leu Ile Gln Ile Pro Glu Glu Tyr Glu Gly His His Val Met
20 25 30
Glu Pro Pro Val Ile Thr Glu Gln Ser Pro Arg Arg Leu Val Val Phe
35 40 45
Pro Thr Asp Asp Ile Ser Leu Lys Cys Glu Ala Ser Gly Lys Pro Glu
50 55 60
Val Gln Phe Arg Trp Thr Arg Asp Gly Val His Phe Lys Pro Lys Glu
65 70 75 80
Glu Leu Gly Val Thr Val Tyr Gln Ser Pro His Ser Gly Ser Phe Thr
85 90 95
Ile Thr Gly Asn Asn Ser Asn Phe Ala Gln Arg Phe Gln Gly Ile Tyr
100 105 110
Arg Cys Phe Ala Ser Asn Lys Leu Gly Thr Ala Met Ser His Glu Ile
115 120 125
Arg Leu Met Ala Glu Gly Ala Pro Lys Trp Pro Lys Glu Thr Val Lys
130 135 140
Pro Val Glu Val Glu Glu Gly Glu Ser Val Val Leu Pro Cys Asn Pro
145 150 155 160
Pro Pro Ser Ala Glu Pro Leu Arg Ile Tyr Trp Met Asn Ser Lys Ile
165 170 175
Leu His Ile Lys Gln Asp Glu Arg Val Thr Met Gly Gln Asn Gly Asn
180 185 190
Leu Tyr Phe Ala Asn Val Leu Thr Ser Asp Asn His Ser Asp Tyr Ile
195 200 205
Cys His Ala His Phe Pro Gly Thr Arg Thr Ile Ile Gln Lys Glu Pro
210 215 220
Ile Asp Leu Arg Val Lys Ala Thr Asn Ser Met Ile Asp Arg Lys Pro
225 230 235 240
Arg Leu Leu Phe Pro Thr Asn Ser Ser Ser His Leu Val Ala Leu Gln
245 250 255
Gly Gln Pro Leu Val Leu Glu Cys Ile Ala Glu Gly Phe Pro Thr Pro
260 265 270
Thr Ile Lys Trp Leu Arg Pro Ser Gly Pro Met Pro Ala Asp Arg Val
275 280 285
Thr Tyr Gln Asn His Asn Lys Thr Leu Gln Leu Leu Lys Val Gly Glu
290 295 300
Glu Asp Asp Gly Glu Tyr Arg Cys Leu Ala Glu Asn Ser Leu Gly Ser
305 310 315 320
Ala Arg His Ala Tyr Tyr Val Thr Val Glu Ala Ala Pro Tyr Trp Leu
325 330 335
His Lys Pro Gln Ser His Leu Tyr Gly Pro Gly Glu Thr Ala Arg Leu
340 345 350
Asp Cys Gln Val Gln Gly Arg Pro Gln Pro Glu Val Thr Trp Arg Ile
355 360 365
Asn Gly Ile Pro Val Glu Glu Leu Ala Lys Asp Gln Lys Tyr Arg Ile
370 375 380
Gln Arg Gly Ala Leu Ile Leu Ser Asn Val Gln Pro Ser Asp Thr Met
385 390 395 400
Val Thr Gln Cys Glu Ala Arg Asn Arg His Gly Leu Leu Leu Ala Asn
405 410 415
Ala Tyr Ile Tyr Val Val Gln Leu Pro Ala Lys Ile Leu Thr Ala Asp
420 425 430
Asn Gln Thr Tyr Met Ala Val Gln Gly Ser Thr Ala Tyr Leu Leu Cys
435 440 445
Lys Ala Phe Gly Ala Pro Val Pro Ser Val Gln Trp Leu Asp Glu Asp
450 455 460
Gly Thr Thr Val Leu Gln Asp Glu Arg Phe Phe Pro Tyr Ala Asn Gly
465 470 475 480
Thr Leu Gly Ile Arg Asp Leu Gln Ala Asn Asp Thr Gly Arg Tyr Phe
485 490 495
Cys Leu Ala Ala Asn Asp Gln Asn Asn Val Thr Ile Met Ala Asn Leu
500 505 510
Lys Val Lys Asp Ala Thr Gln Ile Thr Gln Gly Pro Arg Ser Thr Ile
515 520 525
Glu Lys Lys Gly Ser Arg Val Thr Phe Thr Cys Gln Ala Ser Phe Asp
530 535 540
Pro Ser Leu Gln Pro Ser Ile Thr Trp Arg Gly Asp Gly Arg Asp Leu
545 550 555 560
Gln Glu Leu Gly Asp Ser Asp Lys Tyr Phe Ile Glu Asp Gly Arg Leu
565 570 575
Val Ile His Ser Leu Asp Tyr Ser Asp Gln Gly Asn Tyr Ser Cys Val
580 585 590
Ala Ser Thr Glu Leu Asp Val Val Glu Ser Arg Ala Gln Leu Leu Val
595 600 605
Val Gly Asn Pro Gly Pro Val Pro Arg Leu Val Leu Ser Asp Leu His
610 615 620
Leu Leu Thr Gln Ser Gln Val Arg Val Ser Trp Ser Pro Ala Glu Asp
625 630 635 640
His Asn Ala Pro Ile Glu Lys Tyr Asp Ile Glu Phe Glu Asp Lys Glu
645 650 655
Met Ala Pro Glu Lys Trp Tyr Ser Leu Gly Lys Val Pro Gly Asn Gln
660 665 670
Thr Ser Thr Thr Leu Lys Leu Ser Pro Tyr Val His Tyr Thr Phe Arg
675 680 685
Val Thr Ala Ile Asn Lys Tyr Gly Pro Gly Glu Pro Ser Pro Val Ser
690 695 700
Glu Thr Val Val Thr Pro Glu Ala Ala Pro Glu Lys Asn Pro Val Asp
705 710 715 720
Val Lys Gly Glu Gly Asn Glu Thr Thr Asn Met Val Ile Thr Trp Lys
725 730 735
Pro Leu Arg Trp Met Asp Trp Asn Ala Pro Gln Val Gln Tyr Arg Val
740 745 750
Gln Trp Arg Pro Gln Gly Thr Arg Gly Pro Trp Gln Glu Gln Ile Val
755 760 765
Ser Asp Pro Phe Leu Val Val Ser Asn Thr Ser Thr Phe Val Pro Tyr
770 775 780
Glu Ile Lys Val Gln Ala Val Asn Ser Gln Gly Lys Gly Pro Glu Pro
785 790 795 800
Gln Val Thr Ile Gly Tyr Ser Gly Glu Asp Tyr Pro Gln Ala Ile Pro
805 810 815
Glu Leu Glu Gly Ile Glu Ile Leu Asn Ser Ser Ala Val Leu Val Lys
820 825 830
Trp Arg Pro Val Asp Leu Ala Gln Val Lys Gly His Leu Arg Gly Tyr
835 840 845
Asn Val Thr Tyr Trp Arg Glu Gly Se r Gln Arg Lys His Ser Lys Arg
850 855 860
His Ile His Lys Asp His Val Val Val Pro Ala Asn Thr Thr Ser Val
865 870 875 880
Ile Leu Ser Gly Leu Arg Pro Tyr Ser Ser Tyr His Leu Glu Val Gln
885 890 895
Ala Phe Asn Gly Arg Gly Ser Gly Pro Ala Ser Glu Phe Thr Phe Ser
900 905 910
Thr Pro Glu Gly Val Pro Gly His Pro Glu Ala Leu His Leu Glu Cys
915 920 925
Gln Ser Asn Thr Ser Leu Leu Leu Arg Trp Gln Pro Pro Leu Ser His
930 935 940
Asn Gly Val Leu Thr Gly Tyr Val Leu Ser Tyr His Pro Leu Asp Glu
945 950 955 960
Gly Gly Lys Gly Gln Leu Ser Phe Asn Leu Arg Asp Pro Glu Leu Arg
965 970 975
Thr His Asn Leu Thr Asp Leu Ser Pro His Leu Arg Tyr Arg Phe Gln
980 985 990
Leu Gln Ala Thr Thr Lys Glu Gly Pro Gly Glu Ala Ile Val Arg Glu
995 1000 1005
Gly Gly Thr Met Ala Leu Ser Gly Ile Ser Asp Phe Gly Asn Ile Ser
1010 1015 1020
Ala Thr Ala Gly Glu Asn Tyr Ser Val Val Ser Trp Val Pro Lys Glu
1025 1030 1035 1040
Gly Gln Cys Asn Phe Arg Phe His Ile Leu Phe Lys Ala Leu Gly Glu
1045 1050 1055
Glu Lys Gly Gly Ala Ser Leu Ser Pro Gln Tyr Val Ser Tyr Asn Gln
1060 1065 1070
Ser Ser Tyr Thr Gln Trp Asp Leu Gln Pro Asp Thr Asp Tyr Glu Ile
1075 1080 1085
His Leu Phe Lys Glu Arg Met Phe Arg His Gln Met Ala Val Lys Thr
1090 1095 1100
Asn Gly Thr Gly Arg Val Arg Leu Pro Pro Ala Gly Phe Ala Thr Glu
1105 1110 1115 1120
Gly Trp Phe Ile Gly Phe Val Ser Ala Ile Ile Leu Leu Leu Leu Val
1125 1130 1135
Leu Leu Ile Leu Cys Phe Ile Lys Arg Ser Lys Gly Gly Lys Tyr Ser
1140 1145 1150
Val Lys Asp Lys Glu Asp Thr Gln Val Asp Ser Glu Ala Arg Pro Met
1155 1160 1165
Lys Asp Glu Thr Phe Gly Glu Tyr Arg Ser Leu Glu Ser Asp Asn Glu
1170 1175 1180
Glu Lys Ala Phe Gly Ser Ser Gln Pro Ser Leu Asn Gly Asp Ile Lys
1185 1190 1195 1200
Pro Leu Gly Ser Asp Asp Ser Leu Ala Asp Tyr Gly Gly Ser Val Asp
1205 1210 1215
Val Gln Phe Asn Glu Asp Gly Ser Phe Ile Gly Gln Tyr Ser Gly Lys
1220 1225 1230
Lys Glu Lys Glu Ala Ala Gly Gly Asn Asp Ser Ser Gly Ala Thr Ser
1235 1240 1245
Pro Ile Asn Pro Ala Val Ala Leu Glu
1250 1255
<210>88
<211>1129
<212>PRT
<213>人
<400>88
Met Gly Asp Met Ala Asn Ser Ser Ile Glu Phe His Pro Lys Pro Gln
1 5 10 15
Gln Gln Arg Asp Val Pro Gln Ala Gly Gly Phe Gly Cys Thr Leu Ala
20 25 30
Glu Leu Arg Thr Leu Met Glu Leu Arg Gly Ala Glu Ala Leu Gln Lys
35 40 45
Ile Glu Glu Ala Tyr Gly Asp Val Ser Gly Leu Cys Arg Arg Leu Lys
50 55 60
Thr Ser Pro Thr Glu Gly Leu Ala Asp Asn Thr Asn Asp Leu Glu Lys
65 70 75 80
Arg Arg Gln Ile Tyr Gly Gln Asn Phe Ile Pro Pro Lys Gln Pro Lys
85 90 95
Thr Phe Leu Gln Leu Val Trp Glu Ala Leu Gln Asp Val Thr Leu Ile
100 105 110
Ile Leu Glu Val Ala Ala Ile Val Ser Leu Gly Leu Ser Phe Tyr Ala
115 120 125
Pro Pro Gly Glu Glu Ser Glu Ala Cys Gly Asn Val Ser Gly Gly Ala
130 135 140
Glu Asp Glu Gly Glu Ala Glu Ala Gly Trp Ile Glu Gly Ala Ala Ile
145 150 155 160
Leu Leu Ser Val Ile Cys Val Val Leu Val Thr Ala Phe Asn Asp Trp
165 170 175
Ser Lys Glu Lys Gln Phe Arg Gly Leu Gln Ser Arg Ile Glu Gln Glu
180 185 190
Gln Lys Phe Thr Val Ile Arg Asn Gly Gln Leu Leu Gln Val Pro Val
195 200 205
Ala Ala Leu Val Val Gly Asp Ile Ala Gln Val Lys Tyr Gly Asp Leu
210 215 220
Leu Pro Ala Asp Gly Val Leu Ile Gln Ala Asn Asp Leu Lys Ile Asp
225 230 235 240
Glu Ser Ser Leu Thr Gly Glu Ser Asp His Val Arg Lys Ser Ala Asp
245 250 255
Lys Asp Pro Met Leu Leu Ser Gly Thr His Val Met Glu Gly Ser Gly
260 265 270
Arg Met Val Val Thr Ala Val Gly Val Asn Ser Gln Thr Gly Ile Ile
275 280 285
Phe Thr Leu Leu Gly Ala Gly Gly Glu Glu Glu Glu Lys Lys Asp Lys
290 295 300
Lys Gly Lys Gln Gln Asp Gly Ala Met Glu Ser Ser Gln Thr Lys Ala
305 310 315 320
Lys Lys Gln Asp Gly Ala Val Ala Met Glu Met Gln Pro Leu Lys Ser
325 330 335
Ala Glu Gly Gly Glu Met Glu Glu Arg Glu Lys Lys Lys Ala Asn Ala
340 345 350
Pro Lys Lys Glu Lys Ser Val Leu Gln Gly Lys Leu Thr Lys Leu Ala
355 360 365
Val Gln Ile Gly Lys Ala Gly Leu Val Met Ser Ala Ile Thr Val Ile
370 375 380
Ile Leu Val Leu Tyr Phe Val Ile Glu Thr Phe Val Val Glu Gly Arg
385 390 395 400
Thr Trp Leu Ala Glu Cys Thr Pro Val Tyr Val Gln Tyr Phe Val Lys
405 410 415
Phe Phe Ile Ile Gly Val Thr Val Leu Val Val Ala Val Pro Glu Gly
420 425 430
Leu Pro Leu Ala Val Thr Ile Ser Leu Ala Tyr Ser Val Lys Lys Met
435 440 445
Met Lys Asp Asn Asn Leu Val Arg His Leu Asp Ala Cys Glu Thr Met
450 455 460
Gly Asn Ala Thr Ala Ile Cys Ser Asp Lys Thr Gly Thr Leu Thr Thr
465 470 475 480
Asn Arg Met Thr Val Val Gln Ser Tyr Leu Gly Asp Thr His Tyr Lys
485 490 495
Glu Ile Pro Ala Pro Ser Ala Leu Thr Pro Lys Ile Leu Asp Leu Leu
500 505 510
Val His Ala Ile Ser Ile Asn Ser Ala Tyr Thr Thr Lys Ile Leu Pro
515 520 525
Pro Glu Lys Glu Gly Ala Leu Pro Arg Gln Val Gly Asn Lys Thr Glu
530 535 540
Cys Ala Leu Leu Gly Phe Val Leu Asp Leu Lys Arg Asp Phe Gln Pro
545 550 555 560
Val Arg Glu Gln Ile Pro Glu Asp Lys Leu Tyr Lys Val Tyr Thr Phe
565 570 575
Asn Ser Val Arg Lys Ser Met Ser Thr Val Ile Arg Met Pro Asp Gly
580 585 590
Gly Phe Arg Leu Phe Ser Lys Gly Ala Ser Glu Ile Leu Leu Lys Lys
595 600 605
Cys Thr Asn Ile Leu Asn Ser Asn Gly Glu Leu Arg Gly Phe Arg Pro
610 615 620
Arg Asp Arg Asp Asp Met Val Arg Lys Ile Ile Glu Pro Met Ala Cys
625 630 635 640
Asp Gly Leu Arg Thr Ile Cys Ile Ala Tyr Arg Asp Phe Ser Ala Gly
645 650 655
Gln Glu Pro Asp Trp Asp Asn Glu Asn Glu Val Val Gly Asp Leu Thr
660 665 670
Cys Ile Ala Val Val Gly Ile Glu Asp Pro Val Arg Pro Glu Val Pro
675 680 685
Glu Ala Ile Arg Lys Cys Gln Arg Ala Gly lle Thr Val Arg Met Val
690 695 700
Thr Gly Asp Asn Ile Asn Thr Ala Arg Ala Ile Ala Ala Lys Cys Gly
705 710 715 720
Ile Ile Gln Pro Gly Glu Asp Phe Leu Cys Leu Glu Gly Lys Glu Phe
725 730 735
Asn Arg Arg Ile Arg Asn Glu Lys Gly Glu Ile Glu Gln Glu Arg Leu
740 745 750
Asp Lys Val Trp Pro Lys Leu Arg Val Leu Ala Arg Ser Ser Pro Thr
755 760 765
Asp Lys His Thr Leu Val Lys Gly Ile Ile Asp Ser Thr Thr Gly Glu
770 775 780
Gln Arg Gln Val Val Ala Val Thr Gly Asp Gly Thr Asn Asp Gly Pro
785 790 795 800
Ala Leu Lys Lys Ala Asp Val Gly Phe Ala Met Gly Ile Ala Gly Thr
805 810 815
Asp Val Ala Lys Glu Ala Ser Asp Ile Ile Leu Thr Asp Asp Asn Phe
820 825 830
Thr Ser Ile Val Lys Ala Val Met Trp Gly Arg Asn Val Tyr Asp Ser
835 840 845
Ile Ser Lys Phe Leu Gln Phe Gln Leu Thr Val Asn Val Val Ala Val
850 855 860
Ile Val Ala Phe Thr Gly Ala Cys Ile Thr Gln Asp Ser Pro Leu Lys
865 870 875 880
Ala Val Gln Met Leu Trp Val Asn Leu Ile Met Asp Thr Phe Ala Ser
885 890 895
Leu Ala Leu Ala Thr Glu Pro Pro Thr Glu Ser Leu Leu Leu Arg Lys
900 905 910
Pro Tyr Gly Arg Asp Lys Pro Leu Ile Ser Arg Thr Met Met Lys Asn
915 920 925
Ile Leu Gly His Ala Val Tyr Gln Leu Ala Ile Ile Phe Thr Leu Leu
930 935 940
Phe Val Gly Glu Leu Phe Phe Asp Ile Asp Ser Gly Arg Asn Ala Pro
945 950 955 960
Leu His Ser Pro Pro Ser Glu His Tyr Thr Ile Ile Phe Asn Thr Phe
965 970 975
Val Met Met Gln Leu Phe Asn Glu Ile Asn Ala Arg Lys Ile His Gly
980 985 990
Glu Arg Asn Val Phe Asp Gly Ile Phe Ser Asn Pro Ile Phe Cys Thr
995 1000 1005
Ile Val Leu Gly Thr Phe Gly Ile Gln Ile Val Ile Val Gln Phe Gly
1010 1015 1020
Gly Lys Pro Phe Ser Cys Ser Pro Leu Ser Thr Glu Gln Trp Leu Trp
1025 1030 1035 1040
Cys Leu Phe Val Gly Val Gly Glu Leu Val Trp Gly Gln Val Ile Ala
1045 1050 1055
Thr Ile Pro Thr Ser Gln Leu Lys Cys Leu Lys Glu Ala Gly His Gly
1060 1065 1070
Pro Gly Lys Asp Glu Met Thr Asp Glu Glu Leu Ala Glu Gly Glu Glu
1075 1080 1085
Glu Ile Asp His Ala Glu Arg Glu Leu Arg Arg Gly Gln Ile Leu Trp
1090 1095 1100
Phe Arg Gly Leu Asn Arg Ile Gln Thr Gln Val Cys Trp Arg Gly Lys
1105 1110 1115 1120
Thr Arg Leu Arg Thr Met Lys Tyr Phe
1125
<210>89
<211>1248
<212>PRT
<213>人
<400>89
Met Val Val Ala Leu Arg Tyr Val Trp Pro Leu Leu Leu Cys Ser Pro
1 5 10 15
Cys Leu Leu Ile Gln Ile Pro Glu Glu Leu Met Glu Pro Pro Val Ile
20 25 30
Thr Glu Gln Ser Pro Arg Arg Leu Val Val Phe Pro Thr Asp Asp Ile
35 40 45
Ser Leu Lys Cys Glu Ala Ser Gly Lys Pro Glu Val Gln Phe Arg Trp
50 55 60
Thr Arg Asp Gly Val His Phe Lys Pro Lys Glu Glu Leu Gly Val Thr
65 70 75 80
Val Tyr Gln Ser Pro His Ser Gly Ser Phe Thr Ile Thr Gly Asn Asn
85 90 95
Ser Asn Phe Ala Gln Arg Phe Gln Gly Ile Tyr Arg Cys Phe Ala Ser
100 105 110
Asn Lys Leu Gly Thr Ala Met Ser His Glu Ile Arg Leu Met Ala Glu
115 120 125
Gly Ala Pro Lys Trp Pro Lys Glu Thr Val Lys Pro Val Glu Val Glu
130 135 140
Glu Gly Glu Ser Val Val Leu Pro Cys Asn Pro Pro Pro Ser Ala Glu
145 150 155 160
Pro Leu Arg Ile Tyr Trp Met Asn Ser Lys Ile Leu His Ile Lys Gln
165 170 175
Asp Glu Arg Val Thr Met Gly Gln Asn Gly Asn Leu Tyr Phe Ala Asn
180 185 190
Val Leu Thr Ser Asp Asn His Ser Asp Tyr Ile Cys His Ala His Phe
195 200 205
Pro Gly Thr Arg Thr Ile Ile Gln Lys Glu Pro Ile Asp Leu Arg Val
210 215 220
Lys Ala Thr Asn Ser Met Ile Asp Arg Lys Pro Arg Leu Leu Phe Pro
225 230 235 240
Thr Asn Ser Ser Ser His Leu Val Ala Leu Gln Gly Gln Pro Leu Val
245 250 255
Leu Glu Cys Ile Ala Glu Gly Phe Pro Thr Pro Thr Ile Lys Trp Leu
260 265 270
Arg Pro Ser Gly Pro Met Pro Ala Asp Arg Val Thr Tyr Gln Asn His
275 280 285
Asn Lys Thr Leu Gln Leu Leu Lys Val Gly Glu Glu Asp Asp Gly Glu
290 295 300
Tyr Arg Cys Leu Ala Glu Asn Ser Leu Gly Ser Ala Arg His Ala Tyr
305 310 315 320
Tyr Val Thr Val Glu Ala Ala Pro Tyr Trp Leu His Lys Pro Gln Ser
325 330 335
His Leu Tyr Gly Pro Gly Glu Thr Ala Arg Leu Asp Cys Gln Val Gln
340 345 350
Gly Arg Pro Gln Pro Glu Val Thr Trp Arg Ile Asn Gly Ile Pro Val
355 360 365
Glu Glu Leu Ala Lys Asp Gln Lys Tyr Arg Ile Gln Arg Gly Ala Leu
370 375 380
lle Leu Ser Asn Val Gln Pro Ser Asp Thr Met Val Thr Gln Cys Glu
385 390 395 400
Ala Arg Asn Arg His Gly Leu Leu Leu Ala Asn Ala Tyr Ile Tyr Val
405 410 415
Val Gln Leu Pro Ala Lys Ile Leu Thr Ala Asp Asn Gln Thr Tyr Met
420 425 430
Ala Val Gln Gly Ser Thr Ala Tyr Leu Leu Cys Lys Ala Phe Gly Ala
435 440 445
Pro Val Pro Ser Val Gln Trp Leu Asp Glu Asp Gly Thr Thr Val Leu
450 455 460
Gln Asp Glu Arg Phe Phe Pro Tyr Ala Asn Gly Thr Leu Gly Ile Arg
465 470 475 480
Asp Leu Gln Ala Asn Asp Thr Gly Arg Tyr Phe Cys Leu Ala Ala Asn
485 490 495
Asp Gln Asn Asn Val Thr Ile Met Ala Asn Leu Lys Val Lys Asp Ala
500 505 510
Thr Gln Ile Thr Gln Gly Pro Arg Ser Thr Ile Glu Lys Lys Gly Ser
515 520 525
Arg Val Thr Phe Thr Cys Gln Ala Ser Phe Asp Pro Ser Leu Gln Pro
530 535 540
Ser Ile Thr Trp Arg Gly Asp Gly Arg Asp Leu Gln Glu Leu Gly Asp
545 550 555 560
Ser Asp Lys Tyr Phe Ile Glu Asp Gly Arg Leu Val Ile His Ser Leu
565 570 575
Asp Tyr Ser Asp Gln Gly Asn Tyr Ser Cys Val Ala Ser Thr Glu Leu
580 585 590
Asp Val Val Glu Ser Arg Ala Gln Leu Leu Val Val Gly Ser Pro Gly
595 600 605
Pro Val Pro Arg Leu Val Leu Ser Asp Leu His Leu Leu Thr Gln Ser
610 615 620
Gln Val Arg Val Ser Trp Ser Pro Ala Glu Asp His Asn Ala Pro Ile
625 630 635 640
Glu Lys Tyr Asp Ile Glu Phe Glu Asp Lys Glu Met Ala Pro Glu Lys
645 650 655
Trp Tyr Ser Leu Gly Lys Val Pro Gly Asn Gln Thr Ser Thr Thr Leu
660 665 670
Lys Leu Ser Pro Tyr Val His Tyr Thr Phe Arg Val Thr Ala Ile Asn
675 680 685
Lys Tyr Gly Pro Gly Glu Pro Ser Pro Val Ser Glu Thr Val Val Thr
690 695 700
Pro Glu Ala Ala Pro Glu Lys Asn Pro Val Asp Val Lys Gly Glu Gly
705 710 715 720
Asn Glu Thr Thr Asn Met Val Ile Thr Trp Lys Pro Leu Arg Trp Met
725 730 735
Asp Trp Asn Ala Pro Gln Val Gln Tyr Arg Val Gln Trp Arg Pro Gln
740 745 750
Gly Thr Arg Gly Pro Trp Gln Glu Gln Ile Val Ser Asp Pro Phe Leu
755 760 765
Val Val Ser Asn Thr Ser Thr Phe Val Pro Tyr Glu Ile Lys Val Gln
770 775 780
Ala Val Asn Ser Gln Gly Lys Gly Pro Glu Pro Gln Val Thr Ile Gly
785 790 795 800
Tyr Ser Gly Glu Asp Tyr Pro Gln Ala Ile Pro Glu Leu Glu Gly Ile
805 810 815
Glu Ile Leu Asn Ser Ser Ala Val Leu Val Lys Trp Arg Pro Val Asp
820 825 830
Leu Ala Gln Val Lys Gly His Leu Arg Gly Tyr Asn Val Thr Tyr Trp
835 840 845
Arg Glu Gly Ser Gln Arg Lys His Ser Lys Arg His Ile His Lys Asp
850 855 860
His Val Val Val Pro Ala Asn Thr Thr Ser Val Ile Leu Ser Gly Leu
865 870 875 880
Arg Pro Tyr Ser Ser Tyr His Leu Glu Val Gln Ala Phe Asn Gly Arg
885 890 895
Gly Ser Gly Pro Ala Ser Glu Phe Thr Phe Ser Thr Pro Glu Gly Val
900 905 910
Pro Gly His Pro Glu Ala Leu His Leu Glu Cys Gln Ser Asn Thr Ser
915 920 925
Leu Leu Leu Arg Trp Gln Pro Pro Leu Ser His Asn Gly Val Leu Thr
930 935 940
Gly Tyr Val Leu Ser Tyr His Pro Leu Asp Glu Gly Gly Lys Gly Gln
945 950 955 960
Leu Ser Phe Asn Leu Arg Asp Pro Glu Leu Arg Thr His Asn Leu Thr
965 970 975
Asp Leu Ser Pro His Leu Arg Tyr Arg Phe Gln Leu Gln Ala Thr Thr
980 985 990
Lys Glu Gly Pro Gly Glu Ala Ile Val Arg Glu Gly Gly Thr Met Ala
995 1000 1005
Leu Ser Gly Ile Ser Asp Phe Gly Asn Ile Ser Ala Thr Ala Gly Glu
1010 1015 1020
Asn Tyr Ser Val Val Ser Trp Val Pro Lys Glu Gly Gln Cys Asn Phe
1025 1030 1035 1040
Arg Phe His Ile Leu Phe Lys Ala Leu Gly Glu Glu Lys Gly Gly Ala
1045 1050 1055
Ser Leu Ser Pro Gln Tyr Val Ser Tyr Asn Gln Ser Ser Tyr Thr Gln
1060 1065 1070
Trp Asp Leu Gln Pro Asp Thr Asp Tyr Glu Ile His Leu Phe Lys Glu
1075 1080 1085
Arg Met Phe Arg His Gln Met Ala Val Lys Thr Asn Gly Thr Gly Arg
1090 1095 1100
Val Arg Leu Pro Pro Ala Gly Phe Ala Thr Glu Gly Trp Phe Ile Gly
1105 1110 1115 1120
Phe Val Ser Ala Ile Ile Leu Leu Leu Leu Val Leu Leu Ile Leu Cys
1125 1130 1135
Phe Ile Lys Arg Ser Lys Gly Gly Lys Tyr Ser Val Lys Asp Lys Glu
1140 1145 1150
Asp Thr Gln Val Asp Ser Glu Ala Arg Pro Met Lys Asp Glu Thr Phe
1155 1160 1165
Gly Glu Tyr Ser Asp Asn Glu Glu Lys Ala Phe Gly Ser Ser Gln Pro
1170 1175 1180
Ser Leu Asn Gly Asp Ile Lys Pro Leu Gly Ser Asp Asp Ser Leu Ala
1185 1190 1195 1200
Asp Tyr Gly Gly Ser Val Asp Val Gln Phe Asn Glu Asp Gly Ser Phe
1205 1210 1215
Ile Gly Gln Tyr Ser Gly Lys Lys Glu Lys Glu Ala Ala Gly Gly Asn
1220 1225 1230
Asp Ser Ser Gly Ala Thr Ser Pro Ile Asn Pro Ala Val Ala Leu Glu
1235 1240 1245
<210>90
<211>1164
<212>DNA
<213>人
<400>90
atggtgttcg cattttggaa ggtctttctg atcctaagct gccttgcagg tcaggttagt 60
gtggtgcaag tgaccatccc agacggtttc gtgaacgtga ctgttggatc taatgtcact 120
ctcatctgca tctacaccac cactgtggcc tcccgagaac agctttccat ccagtggtct 180
ttcttccata agaaggagat ggagccaatt tctatttact tttctcaagg tggacaagct 240
gtagccatcg ggcaatttaa agatcgaatt acagggtcca acgatccagg taatgcatct 300
atcactatct cgcatatgca gccagcagac agtggaattt acatctgcga tgttaacaac 360
cccccagact ttctcggcca aaaccaaggc atcctcaacg tcagtgtgtt agtgaaacct 420
tctaagcccc tttgtagcgt tcaaggaaga ccagaaactg gccacactat ttccctttcc 480
tgtctctctg cgcttggaac accttcccct gtgtactact ggcataaact tgagggaaga 540
gacatcgtgc cagtgaaaga aaacttcaac ccaaccaccg ggattttggt cattggaaat 600
ctgacaaatt ttgaacaagg ttattaccag tgtactgcca tcaacagact tggcaatagt 660
tcctgcgaaa tcgatctcac ttcttcacat ccagaagttg gaatcattgt tggggccttg 720
attggtagcc tggtaggtgc cgccatcatc atctctgttg tgtgcttcgc aaggaataag 780
gcaaaagcaa aggcaaaaga aagaaattct aagaccatcg cggaacttga gccaatgaca 840
aagataaacc caaggggaga aagcgaagca atgccaagag aagacgctac ccaactagaa 900
gtaactctac catcttccat tcatgagact ggccctgata ccatccaaga accagactat 960
gagccaaagc ctactcagga gcctgcccca gagcctgccc caggatcaga gcctatggca 1020
gtgcctgacc ttgacatcga gctggagctg gagccagaaa cgcagtcgga attggagcca 1080
gagccagagc cagagccaga gtcagagcct ggggttgtag ttgagccctt aagtgaagat 1140
gaaaagggag tggttaaggc atag 1164
<210>91
<211>516
<212>DNA
<213>人
<400>91
atgtggacgc tgaaatcgtc cctggtcctg cttctgtgcc tcacctgcag ctatgccttt 60
atgttctctt ctctgagaca gaaaactagc gaaccccagg ggaaggtgcc gtgtggagag 120
cactttcgga ttcggcagaa cctaccagag cacacccaag gctggcttgg gagcaaatgg 180
ctctggcttt tgtttgctgt tgtgccgttt gtgatactgc agtgtcaaag agacagtgag 240
aagaataagg agcagagtcc tcctggcctt cgaggcttcc catttcgcac tccactaaag 300
aaaaatcaaa atgcttctct ttacaaagac tgtgtattca ataccttaaa cgaacttgaa 360
gtggagcttt tgaaatttgt gtccgaagtg cagaatctta aaggtgccat ggcaacaggc 420
agtggcagta acctcaagct tcgaaggtca gagatgcctg cagatccata ccatgtcaca 480
atctgtaaaa tatggggaga agaaagctct agctga 516
<210>92
<211>1041
<212>DNA
<213>人
<400>92
atggctcggc ctgggcagcg ttggctcggc aagtggcttg tggcgatggt cgtgtgggcg 60
ctgtgccggc tcgccacacc gctggccaag aacctggagc ccgtatcctg gagctccctc 120
aaccccaagt tcctgagtgg gaagggcttg gtgatctatc cgaaaattgg agacaagctg 180
gacatcatct gcccccgagc agaagcaggg cggccctatg agtactacaa gctgtacctg 240
gtgcggcctg agcaggcagc tgcctgtagc acagttctcg accccaacgt gttggtcacc 300
tgcaataggc cagagcagga aatacgcttt accatcaagt tccaggagtt cagccccaac 360
tacatgggcc tggagttcaa gaagcaccat gattactaca ttacctcaac atccaatgga 420
agcctggagg ggctggaaaa ccgggagggc ggtgtgtgcc gcacacgcac catgaagatc 480
atcatgaagg ttgggcaaga tcccaatgct gtgacgcctg agcagctgac taccagcagg 540
cccagcaagg aggcagacaa cactgtcaag atggccacac aggcccctgg tagtcggggc 600
tccctgggtg actctgatgg caagcatgag actgtgaacc aggaagagaa gagtggccca 660
ggtgcaagtg ggggcagcag cggggaccct gatggcttct tcaactccaa ggtggcattg 720
ttcgcggctg tcggtgccgg ttgcgtcatc ttcctgctca tcatcatctt cctgacggtc 780
ctactactga agctacgcaa gcggcaccgc aagcacacac agcagcgggc ggctgccctc 840
tcgctcagta ccctggccag tcccaagggg ggcagtggca cagcgggcac cgagcccagc 900
gacatcatca ttcccttacg gactacagag aacaactact gcccccacta tgagaaggtg 960
agtggggact acgggcaccc tgtctacatc gtccaagaga tgccgcccca gagcccggcg 1020
aacatctact acaaggtctg a 1041
<210>93
<211>4701
<212>DNA
<213>人
<400>93
ccttcttcag catcttccct gggcattgct gtgagtttag gccggcccgt tttgagcagg 60
agcagcagcg gaacagtaga cctgctggag gaagtggggc tgcagatcag agacacagca 120
ttttcgtcaa ccaaacttct tgaagccata tctacagtat cagctcaagt ggaagagctt 180
gccgtacatg aaatcaaaat ggatccaagt atgggtgtga attctgttac catttctgtt 240
gagggtatga cttgcaattc ctgtgtttgg accattgagc agcagattgg aaaagtgaat 300
ggtgtgcatc acattaaggt atcactggaa gaaaaaaatg caactattat ttatgaccct 360
aaactacaga ctccaaagac cctacaggaa gctattgatg acatgggctt tgatgctgtt 420
atccataatc ctgaccctct ccctgtttta actgacacct tgtttctgac tgttacggcg 480
tcactgactt tgccatggga ccatatccaa agcacattgc tgaagaccaa gggtgtgaca 540
gacattaaaa tttaccctca gaaaagaact gtagcagtga caataatccc ttctatagtg 600
aatgccaatc agataaaaga gctggttcca gaactcagtt tagatactgg gacactggag 660
aaaaagtcag gagcttgtga agatcatagt atggctcaag ctggtgaagt cgtgctgaag 720
atgaaagtgg aagggatgac ctgccattca tgtactagca ctattgaagg aaaaattggg 780
aaactgcaag gtgttcagcg aattaaagtc tccctggaca atcaagaagc tactattgtt 840
tatcaacctc atcttatctc agtagaggaa atgaaaaagc agattgaagc tatgggcttt 900
ccagcatttg tcaaaaagca gcccaagtac ctcaaattgg gagctattga tgtagaacgt 960
ctaaagaaca caccagttaa atcctcagaa gggtcacagc aaaggagtcc atcatatacc 1020
aatgattcaa cagccacttt catcattgat ggcatgcatt gtaaatcatg tgtgtcaaat 1080
attgaaagta ctttatctgc actccaatat gtaagcagca tagtagtttc tttagagaat 1140
aggtctgcca ttgtgaagta taatgcaagc tcagtcactc cagaatccct gagaaaagca 1200
atagaggctg tatcaccggg gctatataga gttagtatca caagtgaagt tgagagtacc 1260
tcaaactctc cctccagctc atctcttcag aagattcctt tgaatgtagt tagccagcct 1320
ctgacacaag aaactgtgat aaacattgat ggcatgactt gtaattcctg tgtgcagtct 1380
attgagggtg tcatatcaaa aaagccaggt gtaaaatcca tacgagtctc ccttgcaaat 1440
agcaatggga ctgttgagta tgatcctcta ctaacctctc cagaaacgtt gagaggagca 1500
atagaagaca tgggatttga tgctaccttg tcagacacga atgagccgtt ggtagtaata 1560
gctcagcctt catcggaaat gccgcttttg acttcaacta atgaatttta tactaaaggg 1620
atgacaccag ttcaagacaa ggaggaagga aagaattcat ctaagtgtta catacaggtc 1680
actggcatga cttgcgcttc ctgtgtagca aacattgaac ggaatttaag gcgggaagaa 1740
ggaatatatt ctatacttgt ggccctgatg gctggcaagg cagaagtaag gtataatcct 1800
gctgttatac aacccccaat gatagcagag ttcatccgag aacttggatt tggagccact 1860
gtgatagaaa atgctgatga aggagatggt gttttggaac ttgttgtgag gggaatgacg 1920
tgtgcctcct gcgtacataa aatagagtct agtctcacaa aacacagagg gatcctatac 1980
tgctccgtgg ccctggcaac caacaaagca catattaaat atgacccaga aattattggt 2040
cctagagata ttatccatac aattgaaagc ttaggttttg aagcttcttt ggtcaagaag 2100
gatcggtcag caagtcactt agatcataaa cgagaaataa gacaatggag acggtctttt 2160
cttgtgagtc tgtttttctg tattcctgta atggggctga tgatatatat gatggttatg 2220
gaccaccact ttgcaactct tcaccataat caaaacatga gtaaagaaga aatgatcaac 2280
cttcattctt ctatgttcct ggagcgccag attcttccag gattgtctgt tatgaatttg 2340
ctgtcctttt tattgtgtgt acctctagaa tttttcggag gctggtactt ctacattcag 2400
gcttataaag cactgaagca taagacagca aatatggacg tactgattgt gctggcaacc 2460
accattgcat ttgcctactc tttgattatt cttctagttg caatgtatga gagagccaaa 2520
gtgaacccta ttactttctt tgacacaccc cctatgctgt ttgtgtttat tgcactaggc 2580
cgatggctgg aacatatagc aaagggcaaa acatcagagg ctcttgcaaa gttaatttca 2640
ctacaagcta cagaagcaac tattgtaact cttgattctg ataatatcct cctcagtgaa 2700
gaacaagtgg atgtggaact tgtacaacgt ggagatatca ttaaagtagt tccaggaggc 2760
aaatttccag tggatggtcg tgttattgaa ggacattcta tggtagatga gtccctcatc 2820
acaggggagg caatgcctgt ggctaagaaa cctggcagca cagtgattgc tggttccatt 2880
aaccagaacg ggtcactgct tatctgcgca acacatgttg gagcagacac aaccctttct 2940
caaattgtca aacttgtgga agaggcacaa acatcaaagg ctcctatcca gcagtttgca 3000
gacaaactca gtggctattt tgttcctttt attgtttttg tttccattgc caccctcttg 3060
gtatggattg taattggatt tctgaatttt gaaattgtgg aaacctactt tcctggctac 3120
aatagaagta tctcccgaac agaaacgata atacgatttg ctttccaagc ctctatcaca 3180
gttctgtgta ttgcatgtcc ctgttcactg ggactggcca ctccaactgc tgtgatggtg 3240
ggtacaggag taggtgctca aaatggcata ctaataaaag gtggagagcc attggagatg 3300
gctcataagg taaaggtagt ggtatttgat aagactggaa ccattactca cggaacccca 3360
gtggtgaatc aagtaaaggt tctaactgaa agtaacagaa tatcacacca taaaatcttg 3420
gccattgtgg gaactgctga aagtaacagt gaacaccctc taggaacagc cataaccaaa 3480
tattgcaaac aggagctgga cactgaaacc ttgggtacct gcatagattt ccaggttgtg 3540
ccaggctgtg gtattagctg taaagtcacc aatattgaag gcttgctaca taagaataac 3600
tggaatatag aggacaataa tattaaaaat gcatccctgg ttcaaattga tgccagtaat 3660
gaacagtcat caacttcgtc ttccatgatt attgatgccc agatctcaaa tgctcttaat 3720
gctcagcagt ataaagtcct cattggtaac cgggagtgga tgattagaaa tggtcttgtc 3780
attaataacg atgtaaatga tttcatgact gaacatgaga gaaaaggtcg gactgctgta 3840
ttagtagcag ttgatgatga gctgtgtggc ttgatagcca ttgcagacac agtgaagcct 3900
gaagcagaac tggctatcca tattctgaaa tctatgggct tagaagtagt tctgatgact 3960
ggagacaaca gtaaaacagc tagatctatt gcttctcagg ttggcattac taaggtgttt 4020
gctgaagttc taccttctca caaggttgct aaagtgaagc aacttcaaga ggaggggaaa 4080
cgggtagcaa tggtgggaga tggaatcaat gactccccag ctctggcaat ggctaatgtg 4140
ggaattgcta ttggcacagg cacagatgta gccattgaag cagctgatgt ggttttgata 4200
aggaatgatc ttctggatgt agtggcaagt attgacttat caagagagac agtcaagagg 4260
attcggataa attttgtctt tgctctaatt tataatctgg ttggaattcc catagctgct 4320
ggagttttta tgcccattgg tttggttttg cagccctgga tgggatctgc agcaatggct 4380
gcttcatctg tttctgtagt actttcttct ctcttcctta aactttacag gaaaccaact 4440
tacgagagtt atgaactgcc tgcccggagc cagataggac agaagagtcc ttcagaaatc 4500
agcgttcatg ttggaataga tgatacctca aggaattctc ctaaactggg tttgctggac 4560
cggattgtta attatagcag agcctctata aactcactac tgtctgataa acgctcccta 4620
aacagtgttg ttaccagtga acctgacaag cactcactcc tggtgggaga cttcagggaa 4680
gatgatgaca ctgcattata a 4701
<210>94
<211>516
<212>DNA
<213>人
<400>94
atgtggacgc tgaaatcgtc cctggtcctg cttctgtgcc tcacctgcag ctatgccttt 60
atgttctct tctctgagaca gaaaactagc gaaccccagg ggaaggtgca atacggagag 120
cactttcgga ttcggcagaa tctaccagag cacacccaag gctggcttgg gagcaaatgg 180
ctctggcttc tttttgttgt tgtgccgttt gtgatactgc agtgtcaaag agacagtgag 240
aagaataagg agcagagtcc tcctggcctt cgaggcttcc catttcgcac tccactaaag 300
aaaaatcaaa atgcttctct ttacaaagac tgtgtattca ataccttaaa cgaacttgaa 360
gtggagcttt tgaaatttgt gtccgaagtg cagaatctta aaggtgccat ggcaacaggc 420
agtggcagta acctcaagct tcgaaggtca gagatgcctg cagatccata ccatgtcaca 480
atctgtaaaa tatggggaga agaaagctct agctga 516
<210>95
<211>1068
<212>DNA
<213>人
<400>95
atgacaacct cactagatac agttgagacc tttggtacca catcctacta tgatgacgtg 60
ggcctgctct gtgaaaaagc tgataccaga gcactgatgg cccagtttgt gcccccgctg 120
tactccctgg tgttcactgt gggcctcttg ggcaatgtgg tggtggtgat gatcctcata 180
aaatacagga ggctccgaat tatgaccaac atctacctgc tcaacctggc catttcggac 240
ctgctcttcc tcgtcaccct tccattctgg atccactatg tcagggggca taactgggtt 300
tttggccatg gcatgtgtaa gctcctctca gggttttatc acacaggctt gtacagcgag 360
atctttttca taatcctgct gacaatcgac aggtacctgg ccattgtcca tgctgtgttt 420
gcccttcgag cccggactgt cacttttggt gtcatcacca gcatcgtcac ctggggcctg 480
gcagtgctag cagctcttcc tgaatttatc ttctatgaga ctgaagagtt gtttgaagag 540
actctttgca gtgctcttta cccagaggat acagtatata gctggaggca tttccacact 600
ctgagaatga ccatcttctg tctcgttctc cctctgctcg ttatggccat ctgctacaca 660
ggaatcatca aaacgctgct gaggtgcccc agtaaaaaaa agtacaaggc catccggctc 720
atttttgtca tcatggcggt gtttttcatt ttctggacac cctacaatgt ggctatcctt 780
ctctcttcct atcaatccat cttatttgga aatgactgtg agcggagcaa gcatctggac 840
ctggtcatgc tggtgacaga ggtgatcgcc tactcccact gctgcatgaa cccggtgatc 900
tacgcctttg ttggagagag gttccggaag tacctgcgcc acttcttcca caggcacttg 960
ctcatgcacc tgggcagata catcccattc cttcctagtg agaagctgga aagaaccagc 1020
tctgtctctc catccacagc agagccggaa ctctctattg tgttttag 1068
<210>96
<211>1200
<212>DNA
<213>人
<400>96
atggctcaaa ggcagcctca ctcacctaat cagactttaa tttcaatcac aaatgacaca 60
gaatcatcaa gctctgtggt ttctaacgat aacacaaata aaggatggag cggggacaac 120
tctccaggaa tagaagcatt gtgtgccatc tatattactt atgctgtgat catttcagtg 180
ggcatccttg gaaatgctat tctcatcaaa gtctttttca agaccaaatc catgcaaaca 240
gttccaaata ttttcatcac cagcctggct tttggagatc ttttacttct gctaacttgt 300
gtgccagtgg atgcaactca ctaccttgca gaaggatggc tgttcggaag aattggttgt 360
aaggtgctct ctttcatccg gctcacttct gttggtgtgt cagtgttcac attaacaatt 420
ctcagcgctg acagatacaa ggcagttgtg aagccacttg agcgacagcc ctccaatgcc 480
atcctgaaga cttgtgtaaa agctggctgc gtctggatcg tgtctatgat atttgctcta 540
cctgaggcta tattttcaaa tgtatacact tttcgagatc ccaataaaaa tatgacattt 600
gaatcatgta cctcttatcc tgtctctaag aagctcttgc aagaaataca ttctctgctg 660
tgcttcttag tgttctacat tattccactc tctattatct ctgtctacta ttccttgatt 720
gctaggaccc tttacaaaag caccctgaac atacctactg aggaacaaag ccatgcccgt 780
aagcagattg aatcccgaaa gagaattgcc agaacggtat tggtgttggt ggctctgttt 840
gccctctgct ggttgccaaa tcacctcctg tacctctacc attcattcac ttctcaaacc 900
tatgtagacc cctctgccat gcatttcatt ttcaccattt tctctcgggt tttggctttc 960
agcaattctt gcgtaaaccc ctttgctctc tactggctga gcaaaagctt ccagaagcat 1020
tttaaagctc agttgttctg ttgcaaggcg gagcggcctg agcctcctgt tgctgacacc 1080
tctcttacca ccctggctgt gatgggaacg gtcccgggca ctgggagcat acagatgtct 1140
gaaattagtg tgacctcgtt cactgggtgt agtgtgaagc aggcagagga cagattctag 1200
<210>97
<211>516
<212>DNA
<213>人
<400>97
atgtggacgc tgaaatcgtc cctggtcctg cttctgtgcc tcacctgcag ctatgccttt 60
atgttctctt ctctgagaca gaaaactagc gaaccccagg ggaaggtgca atacggagag 120
cactttcgga ttcggcagaa tctaccagag cacacccaag gctggcttgg gagcaaatgg 180
ctctggcttc tttttgttgt tgtgccgttt gtgatactgc agtgtcaaag agacagtgag 240
aagaataagg agcagagtcc tcctggcctt cgaggcggcc aacttcactc tccattaaag 300
aaaaaaagaa atgcttcccc caacaaagac tgtgcattca ataccttaat ggaactcgag 360
gtggagctta tgaaatttgt gtccaaagtg cggaatctta aacgtgccat ggcaacaggt 420
agtggcagta acctcaggct tcgaaagtca gagatgcctg cagatccata ccatgtcacg 480
atctgtgaaa tatggggaga agaaagctct agctga 516
<210>98
<211>654
<212>DNA
<213>人
<400>98
atggcggagt tcgacaccat ctcggaactg gaggaggagg aggaagaaga agcggcaacg 60
tcgtcgtcgt cgccgtcgtc gtcgtcgtcg gtatctgggc ccgacgatga cgaggaggat 120
gaggaggaag aggaggaaga ggaggaggag gaagaagagg aggaggagga agaggaggag 180
gaagcgccgc ccccgcctcg ggtagtgagc gaggagcatc tgcggagata tgctcccgac 240
cctgtattag tgcggggtgc cggccacatc actgtgtttg gcttgagcaa caagtttgat 300
actgaatttc cctccgttct aacagggaag gtggccccag aagaatttaa aaccagcatt 360
ggccgtgtga atgcatgttt gaaaaaggct ctcccggtca atgtgaaatg gctgctgtgt 420
ggttgtctct gctgctgttg cacactgggt tgcagcctat ggcctgttat ttgtctcaac 480
aaaagaacca gaagatcaat tcagaagtta atagaatggg aaaataacag attatatcac 540
aagcttgctt tgcactggaa gttgactaag aggaaatgtg aaactagcaa tatgatggag 600
tatgtaatac taatagaatt cttaccaaaa tatcccatat tccgacctga ctga 654
<210>99
<211>654
<212>DNA
<213>人
<400>99
atggcggagt tcgacaccat ctcggaactg gaggaggagg aggaagaaga agcggcaacg 60
tcgtcgtcgt cgccgtcgtc gtcgtcgtcg gtatctgggc ccgacgatga cgaggaggat 120
gaggaggaag aggaggaaga ggaggaggag gaagaagagg aggaggagga agaggaggag 180
gaagcgccgc ccccgcctcg ggtagtgagc gaggagcatc tgcggagata tgctcccgac 240
cctgtattag tgcggggtgc cggccacatc actgtgtttg gcttgagcaa caagtttgat 300
actgaatttc cctccgttct aacagggaag gtggccccag aagaatttaa aaccagcatt 360
ggccgtgtga atgcatgttt gaaaaaggct ctcccggtca atgtgaaatg gctgctgtgt 420
ggttgtctct gctgctgttg cacactgggt tgcagcctat ggcctgttat ttgtctcaac 480
aaaagaacca gaagatcaat tcagaagtta atagaatggg aaaataacag attatatcac 540
aagcttgctt tgcactggaa gttgactaag aggaaatgtg aaactagcaa tatgatggag 600
tatgtaatac taatagaatt cttaccaaaa tatcccatat tccgacctga ctga 654
<210>100
<211>4269
<212>DNA
<213>人
<400>100
atggatccaa gtatgggtgt gaattctgtt accatttctg ttgagggtat gacttgcaat 60
tcctgtgttt ggaccattga gcagcagatt ggaaaagtga atggtgtgca tcacattaag 120
gtatcactgg aagaaaaaaa tgcaactatt atttatgacc ctaaactaca gactccaaag 180
accctacagg aagctattga tgacatgggc tttgatgctg ttatccataa tcctgaccct 240
ctccctgttt taactgacac cttgtttctg actgttacgg cgtcactgac tttgccatgg 300
gaccatatcc aaagcacatt gctgaagacc aagggtgtga cagacattaa aatttaccct 360
cagaaaagaa ctgtagcagt gacaataatc ccttctatag tgaatgccaa tcagataaaa 420
gagctggttc cagaactcag tttagatact gggacactgg agaaaaagtc aggagcttgt 480
gaagatcata gtatggctca agctggtgaa gtcgtgctga agatgaaagt ggaagggatg 540
acctgccatt catgtactag cactattgaa ggaaaaattg ggaaactgca aggtgttcag 600
cgaattaaag tctccctgga caatcaagaa gctactattg tttatcaacc tcatcttatc 660
tcagtagagg aaatgaaaaa gcagattgaa gctatgggct ttccagcatt tgtcaaaaag 720
cagcccaagt acctcaaatt gggagctatt gatgtagaac gtctaaagaa cacaccagtt 780
aaatcctcag aagggtcaca gcaaaggagt ccatcatata ccaatgattc aacagccact 840
ttcatcattg atggcatgca ttgtaaatca tgtgtgtcaa atattgaaag tactttatct 900
gcactccaat atgtaagcag catagtagtt tctttagaga ataggtctgc cattgtgaag 960
tataatgcaa gctcagtcac tccagaatcc ctgagaaaag caatagaggc tgtatcaccg 1020
gggctatata gagttagtat cacaagtgaa gttgagagta cctcaaactc tccctccagc 1080
tcatctcttc agaagattcc tttgaatgta gttagccagc ctctgacaca agaaactgtg 1140
ataaacattg atggcatgac ttgtaattcc tgtgtgcagt ctattgaggg tgtcatatca 1200
aaaaagccag gtgtaaaatc catacgagtc tcccttgcaa atagcaatgg gactgttgag 1260
tatgatcctc tactaacctc tccagaaacg ttgagaggag caatagaaga catgggattt 1320
gatgctacct tgtcagacac gaatgagccg ttggtagtaa tagctcagcc ttcatcggaa 1380
atgccgcttt tgacttcaac taatgaattt tatactaaag ggatgacacc agttcaagac 1440
aaggaggaag gaaagaattc atctaagtgt tacatacagg tcactggcat gacttgcgct 1500
tcctgtgtag caaacattga acggaattta aggcgggaag aaggaatata ttctatactt 1560
gtggccctga tggctggcaa ggcagaagta aggtataatc ctgctgttat acaaccccca 1620
atgatagcag agttcatccg agaacttgga tttggagcca ctgtgataga aaatgctgat 1680
gaaggagatg gtgttttgga acttgttgtg aggggaatga cgtgtgcctc ctgcgtacat 1740
aaaatagagt ctagtctcac aaaacacaga gggatcctat actgctccgt ggccctggca 1800
accaacaaag cacatattaa atatgaccca gaaattattg gtcctagaga tattatccat 1860
acaattgaaa gcttaggttt tgaagcttct ttggtcaaga aggatcggtc agcaagtcac 1920
ttagatcata aacgagaaat aagacaatgg agacggtctt ttcttgtgag tctgtttttc 1980
tgtattcctg taatggggct gatgatatat atgatggtta tggaccacca ctttgcaact 2040
cttcaccata atcaaaacat gagtaaagaa gaaatgatca accttcattc ttctatgttc 2100
ctggagcgcc agattcttcc aggattgtct gttatgaatt tgctgtcctt tttattgtgt 2160
gtacctctag aaggcaaaac atcagaggct cttgcaaagt taatttcact acaagctaca 2220
gaagcaacta ttgtaactct tgattctgat aatatcctcc tcagtgaaga acaagtggat 2280
gtggaacttg tacaacgtgg agatatcatt aaagtagttc caggaggcaa atttccagtg 2340
gatggtcgtg ttattgaagg acattctatg gtagatgagt ccctcatcac aggggaggca 2400
atgcctgtgg ctaagaaacc tggcagcaca gtgattgctg gttccattaa ccagaacggg 2460
tcactgctta tctgcgcaac acatgttgga gcagacacaa ccctttctca aattgtcaaa 2520
cttgtggaag aggcacaaac atcaaaggct cctatccagc agtttgcaga caaactcagt 2580
ggctattttg ttccttttat tgtttttgtt tccattgcca ccctcttggt atggattgta 2640
attggatttc tgaattttga aattgtggaa acctactttc ctggctacaa tagaagtatc 2700
tcccgaacag aaacgataat acgatttgct ttccaagcct ctatcacagt tctgtgtatt 2760
gcatgtccct gttcactggg actggccact ccaactgctg tgatggtggg tacaggagta 2820
ggtgctcaaa atggcatact aataaaaggt ggagagccat tggagatggc tcataaggta 2880
aaggtagtgg tatttgataa gactggaacc attactcacg gaaccccagt ggtgaatcaa 2940
gtaaaggttc taactgaaag taacagaata tcacaccata aaatcttggc cattgtggga 3000
actgctgaaa gtaacagtga acaccctcta ggaacagcca taaccaaata ttgcaaacag 3060
gagctggaca ctgaaacctt gggtacctgc atagatttcc aggttgtgcc aggctgtggt 3120
attagctgta aagtcaccaa tattgaaggc ttgctacata agaataactg gaatatagag 3180
gacaataata ttaaaaatgc atccctggtt caaattgatg ccagtaatga acagtcatca 3240
acttcgtctt ccatgattat tgatgcccag atctcaaatg ctcttaatgc tcagcagtat 3300
aaagtcctca ttggtaaccg ggagtggatg attagaaatg gtcttgtcat taataacgat 3360
gtaaatgatt tcatgactga acatgagaga aaaggtcgga ctgctgtatt agtagcagtt 3420
gatgatgagc tgtgtggctt gatagccatt gcagacacag tgaagcctga agcagaactg 3480
gctatccata ttctgaaatc tatgggctta gaagtagttc tgatgactgg agacaacagt 3540
aaaacagcta gatctattgc ttctcaggtt ggcattacta aggtgtttgc tgaagttcta 3600
ccttctcaca aggttgctaa agtgaagcaa cttcaagagg aggggaaacg ggtagcaatg 3660
gtgggagatg gaatcaatga ctccccagct ctggcaatgg ctaatgtggg aattgctatt 3720
ggcacaggca cagatgtagc cattgaagca gctgatgtgg ttttgataag gaatgatctt 3780
ctggatgtag tggcaagtat tgacttatca agagagacag tcaagaggat tcggataaat 3840
tttgtctttg ctctaattta taatctggtt ggaattccca tagctgctgg agtttttatg 3900
cccattggtt tggttttgca gccctggatg ggatctgcag caatggctgc ttcatctgtt 3960
tctgtagtac tttcttctct cttccttaaa ctttacagga aaccaactta cgagagttat 4020
gaactgcctg cccggagcca gataggacag aagagtcctt cagaaatcag cgttcatgtt 4080
ggaatagatg atacctcaag gaattctcct aaactgggtt tgctggaccg gattgttaat 4140
tatagcagag cctctataaa ctcactactg tctgataaac gctccctaaa cagtgttgtt 4200
accagtgaac ctgacaagca ctcactcctg gtgggagact tcagggaaga tgatgacact 4260
gcattataa 4269
<210>101
<211>1512
<212>DNA
<213>人
<400>101
atggatccaa gtatgggtgt gaattctgtt accatttctg ttgagggtat gacttgcaat 60
tcctgtgttt ggaccattga gcagcagatt ggaaaagtga atggtgtgca tcacattaag 120
gtaaaggtag tggtatttga taagactgga accattactc acggaacccc agtggtgaat 180
caagtaaagg ttctaactga aagtaacaga atatcacacc ataaaatctt ggccattgtg 240
ggaactgctg aaagtaacag tgaacaccct ctaggaacag ccataaccaa atattgcaaa 300
caggagctgg acactgaaac cttgggtacc tgcatagatt tccaggttgt gccaggctgt 360
ggtattagct gtaaagtcac caatattgaa ggcttgctac ataagaataa ctggaatata 420
gaggacaata atattaaaaa tgcatccctg gttcaaattg atgccagtaa tgaacagtca 480
tcaacttcgt cttccatgat tattgatgcc cagatctcaa atgctcttaa tgctcagcag 540
tataaagtcc tcattggtaa ccgggagtgg atgattagaa atggtcttgt cattaataac 600
gatgtaaatg atttcatgac tgaacatgag agaaaaggtc ggactgctgt attagtagca 660
gttgatgatg agctgtgtgg cttgatagcc attgcagaca cagtgaagcc tgaagcagaa 720
ctggctatcc atattctgaa atctatgggc ttagaagtag ttctgatgac tggagacaac 780
agtaaaacag ctagatctat tgcttctcag gttggcatta ctaaggtgtt tgctgaagtt 840
ctaccttctc acaaggttgc taaagtgaag caacttcaag aggaggggaa acgggtagca 900
atggtgggag atggaatcaa tgactcccca gctctggcaa tggctaatgt gggaattgct 960
attggcacag gcacagatgt agccattgaa gcagctgatg tggttttgat aaggaatgat 1020
cttctggatg tagtggcaag tattgactta tcaagagaga cagtcaagag gattcggata 1080
aattttgtct ttgctctaat ttataatctg gttggaattc ccatagctgc tggagttttt 1140
atgcccattg gtttggtttt gcagccctgg atgggatctg cagcaatggc tgcttcatct 1200
gtttctgtag tactttcttc tctcttcctt aaactttaca ggaaaccaac ttacgagagt 1260
tatgaactgc ctgcccggag ccagatagga cagaagagtc cttcagaaat cagcgttcat 1320
gttggaatag atgatacctc aaggaattct cctaaactgg gtttgctgga ccggattgtt 1380
aattatagca gagcctctat aaactcacta ctgtctgata aacgctccct aaacagtgtt 1440
gttaccagtg aacctgacaa gcactcactc ctggtgggag acttcaggga agatgatgac 1500
actgcattat aa 1512
<210>102
<211>1053
<212>DNA
<213>人
<400>102
atggctgtgt ttgtcgtgct cctggcgttg gtggcgggtg ttttggggaa cgagtttagt 60
atattaaaat caccagggtc tgttgttttc cgaaatggaa attggcctat accaggagag 120
cggatcccag acgtggctgc attgtccatg ggcttctctg tgaaagaaga cctttcttgg 180
ccaggactcg cagtgggtaa cctgtttcat cgtcctcggg ctaccgtcat ggtgatggtg 240
aagggagtga acaaactggc tctaccccca ggcagtgtca tttcgtaccc tttggagaat 300
gcagttcctt ttagtcttga cagtgttgca aattccattc actccttatt ttctgaggaa 360
actcctgttg ttttgcagtt ggctcccagt gaggaaagag tgtatatggt agggaaggca 420
aactcagtgt ttgaagacct ttcagtcacc ttgcgccagc tccgtaatcg cctgtttcaa 480
gaaaactctg ttctcagttc actccccctc aattctctga gtaggaacaa tgaagttgac 540
ctgctctttc tttctgaact gcaagtgcta catgatattt caagcttgct gtctcgtcat 600
aagcatctag ccaaggatca ttctcctgat ttatattcac tggagctggc aggtttggat 660
gaaattggga agcgttatgg ggaagactct gaacaattca gagatgcttc taagatcctt 720
gttgacgctc tgcaaaagtt tgcagatgac atgtacagtc tttatggtgg gaatgcagtg 780
gtagagttag tcactgtcaa gtcatttgac acctccctca ttaggaagac aaggactatc 840
cttgaggcaa aacaagcgaa gaacccagca agtccctata accttgcata taagtataat 900
tttgaatatt ccgtggtttt caacatggta ctttggataa tgatcgcctt ggccttggct 960
gtgattatca cctcttacaa tatttggaac atggatcctg gatatgatag catcatttat 1020
aggatgacaa accagaagat tcgaatggat tga 1053
<210>103
<211>1335
<212>DNA
<213>人
<400>103
atgaaattcc cggcctcggt gctggcgtcc gtgttcctgt tcgtggccga gacaacggcg 60
gcgctcagcc tgagcagcac ctaccgctcg ggcggggacc gcatgtggca ggcgctgacg 120
ttgcttttct cgctactgcc ttgcgcgctc gtgcagctca cgcttctctt cgtacaccgc 180
gacctcagcc gcgaccgccc gctcgtactg ctgctgcacc tgctgcaact tgggcccctt 240
ttcaggtgtt ttgaagtctt ctgcatctac tttcagtcag gcaacaatga agagccttat 300
gtcagtatca ccaagaagag gcaaatgcca aaaaatggcc tctcagagga gattgagaag 360
gaggtgggcc aggcagaagg caaactaatc acccaccgat cagcgttcag ccgggcgtcg 420
gtgatccagg ctttcttggg ctcagccccc cagctgaccc tacagctgta cataagtgtc 480
atgcagcagg acgtcactgt tggaagaagt ctcctcatga ccatatccct gttgtccatt 540
gtgtatggag ccttgcgctg caacatccta gccatcaaaa tcaagtacga tgagtatgaa 600
gtcaaagtga agcctctggc ctatgtctgt atcttcctgt ggaggagctt tgagattgcc 660
actcgagttg tagtcctggt cctctttacc tccgtcctga agacctgggt ggtggttata 720
atactcatca acttcttcag tttcttcttg tacccctgga tcctcttctg gtgcagtggt 780
tccccattcc ctgagaacat agagaaggcc ctcagtagag tgggcaccac cattgtacta 840
tgctttctaa ctttactcta tactggtatc aacatgttct gctggtctgc tgtacagctg 900
aaaattgaca gccctgacct catcagcaag tcccataatt ggtaccagct actggtgtat 960
tacatgataa gattcatcga gaatgccatc ctcctcctcc tgtggtatct tttcaagact 1020
gacatctata tgtatgtgtg cgcacctctg ttggtcctgc agctgctcat tgggtactgc 1080
acagccattc tcttcatgct tgtattctat cagttcttcc acccttgcaa aaagctcttt 1140
tcttccagtg tttctgaagg ctttcagagg tggctcaggt gtttttgctg ggcctgcagg 1200
cagcaaaaac cctgtgagcc gataggaaag gaagatctac agtcatccag agatagagat 1260
gagacacctt ctagcagtaa aacaagtcct gagcctggtc agttcttgaa tgctgaagat 1320
ctctgctctg cttaa 1335
<210>104
<211>642
<212>DNA
<213>人
<400>104
gccaccatgg tctggttctg caacagtgcc gactgccaat tttcagtctt cgcccttacc 60
accataggat ggatcctctc ctctacgtcc acgggcctcg tggagtggcg aatatggtac 120
atgaaagaca cctcgctcta cccccctgga atcgcctgcg tgggaatatt tagagtctgc 180
atttaccggc gtcgcaccaa cagcaccaca accaaatttt gttaccgata cagctaccag 240
gacacctttc tcccttttga aatttccatg gctcaacgct tcctactgac tgccagcatt 300
ttcggattct tcgggagagc ctttaacatg tttgcactta gaaacatgtc catgagaatg 360
tttgaggagg acacctacaa ttcattcgtt gtttcaggaa ttctcaacat tgctgctggt 420
gtctttaact taattgctgt gctccagaac tacgatgccg tcataaactc acaggggatc 480
accttcctgc catctctcca aatgcccttc aagccagatg tgcaggaagt tggcactgcc 540
attcaagtgg cagggatagg tgtcttgccg atgctgttaa ctgggatgtt ttctctgttt 600
tacaaatgtc cccccatgct ctaccaaata tttccaacga ct 642
<210>105
<211>588
<212>DNA
<213>人
<400>105
atggctgccg aggatgtggt ggcgactggc gccgacccaa gcgatctgga gagcggcggg 60
ctgctgcatg agattttcac gtcgccgctc aacctgctgc tgcttggcct ctgcatcttc 120
ctgctctaca agatcgtgcg cggggaccag ccggcggcca gcggcgacag cgacgacgac 180
gagccgcccc ctctgccccg cctcaagcgg cgcgacttca cccccgccga gctgcggcgc 240
ttcgacggcg tccaggaccc gcgcatactc atggccatca acggcaaggt gttcgatgtg 300
accaaaggcc gcaaattcta cgggcccgag gggccgtatg gggtctttgc tggaagagat 360
gcatccaggg gccttgccac attttgcctg gataaggaag cactgaagga tgagtacgat 420
gacctttctg acctcactgc tgcccagcag gagactctga gtgactggga gtctcagttc 480
actttcaagt atcatcacgt gggcaaactg ctgaaggagg gggaggagcc cactgtgtac 540
tcagatgagg aagaaccaaa agatgagagt gcccggaaaa atgattaa 588
<210>106
<211>267
<212>DNA
<213>人
<400>106
caggaatgta atgaggaaat caaaatggat ccaagtatgg gtgtgaattc tgttaccatt 60
tctgttgagg gtatgacttg caattcctgt gtttggacca ttgagcagca gattggaaaa 120
gtgaatggtg tgcatcacat taaggtaatt tctttagaga ataggtctgc cattgtgaat 180
ttttatgccc attggtttgg ttttgcagcc ctggatggga tctgcagcaa tggctgcttc 240
atctgtttct gtagtacttt cttctct 267
<210>107
<211>1164
<212>DNA
<213>人
<400>107
atgagagaac ccctggaggc gtttaagttg gcagacttgg atttcaggaa gagctctctg 60
gcttctgggt ggagaatggc cagtggggcc ttcaccatgg atcagttccc tgaatcagtg 120
acagaaaact ttgagtacga tgatttggct gaggcctgtt atattgggga catcgtggtc 180
tttgggactg tgttcctgtc catattctac tccgtcatct ttgccattgg cctggtggga 240
aatttgttgg tagtgtttgc cctcaccaac agcaagaagc ccaagagtgt caccgacatt 300
tacctcctga acctggcctt gtctgatctg ctgtttgtag ccactttgcc cttctggact 360
cactatttga taaatgaaaa gggcctccac aatgccatgt gcaaattcac taccgccttc 420
ttcttcatcg gcttttttgg aagcatattc ttcatcaccg tcatcagcat tgataggtac 480
ctggccatcg tcctggccgc caactccatg aacaaccgga ccgtgcagca tggcgtcacc 540
atcagcctag gcgtctgggc agcagccatt ttggtggcag caccccagtt catgttcaca 600
aagcagaaag aaaatgaatg ccttggtgac taccccgagg tcctccagga aatctggccc 660
gtgctccgca atgtggaaac aaattttctt ggcttcctac tccccctgct cattatgagt 720
tattgctact tcagaatcat ccagacgctg ttttcctgca agaaccacaa gaaagccaaa 780
gccattaaac tgatccttct ggtggtcatc gtgtttttcc tcttctggac accctacaac 840
gttatgattt tcctggagac gcttaagctc tatgacttct ttcccagttg tgacatgagg 900
aaggatctga ggctggccct cagtgtgact gagacggttg catttagcca ttgttgcctg 960
aatcctctca tctatgcatt tgctggggag aagttcagaa gataccttta ccacctgtat 1020
gggaaatgcc tggctgtcct gtgtgggcgc tcagtccacg ttgatttctc ctcatctgaa 1080
tcacaaagga gcaggcatgg aagtgttctg agcagcaatt ttacttacca cacgagtgat 1140
ggagatgcat tgctccttct ctga 1164
<210>108
<211>1107
<212>DNA
<213>人
<400>108
atggtccttg aggtgagtga ccaccaagtg ctaaatgacg ccgaggttgc cgccctcctg 60
gagaacttca gctcttccta tgactatgga gaaaacgaga gtgactcgtg ctgtacctcc 120
ccgccctgcc cacaggactt cagcctgaac ttcgaccggg ccttcctgcc agccctctac 180
agcctcctct ttctgctggg gctgctgggc aacggcgcgg tggcagccgt gctgctgagc 240
cggcggacag ccctgagcag caccgacacc ttcctgctcc acctagctgt agcagacacg 300
ctgctggtgc tgacactgcc gctctgggca gtggacgctg ccgtccagtg ggtctttggc 360
tctggcctct gcaaagtggc aggtgccctc ttcaacatca acttctacgc aggagccctc 420
ctgctggcct gcatcagctt tgaccgctac ctgaacatag ttcatgccac ccagctctac 480
cgccgggggc ccccggcccg cgtgaccctc acctgcctgg ctgtctgggg gctctgcctg 540
cttttcgccc tcccagactt catcttcctg tcggcccacc acgacgagcg cctcaacgcc 600
acccactgcc aatacaactt cccacaggtg ggccgcacgg ctctgcgggt gctgcagctg 660
gtggctggct ttctgctgcc cctgctggtc atggcctact gctatgccca catcctggcc 720
gtgctgctgg tttccagggg ccagcggcgc ctgcgggcca tgcggctggt ggtggtggtc 780
gtggtggcct ttgccctctg ctggaccccc tatcacctgg tggtgctggt ggacatcctc 840
atggacctgg gcgctttggc ccgcaactgt ggccgagaaa gcagggtaga cgtggccaag 900
tcggtcacct caggcctggg ctacatgcac tgctgcctca acccgctgct ctatgccttt 960
gtaggggtca agttccggga gcggatgtgg atgctgctct tgcgcctggg ctgccccaac 1020
cagagagggc tccagaggca gccatcgtct tcccgccggg attcatcctg gtctgagacc 1080
tcagaggcct cctactcggg cttgtga 1107
<210>109
<211>801
<212>DNA
<213>人
<400>109
atggtccttg aggtgagtga ccaccaagtg ctaaatgacg ccgaggttgc cgccctcctg 60
gagaacttca gctcttccta tgactatgga gaaaacgaga gtgactcgtg ctgtacctcc 120
ccgccctgcc cacaggactt cagcctgaac ttcgaccggg ccttcctgcc agccctctac 180
agcctcctct ttctgctggg gctgctgggc aacggcgcgg tggcagccgt gctgctgagc 240
cggcggacag ccctgagcag caccgacacc ttcctgctcc acctagctgt agcagacacg 300
ctgctggtgc tgacactgcc gctctgggca gtggacgctg ccgtccagtg ggtctttggc 360
tctggcctct gcaaagtggc aggtgccctc ttcaacatca acttctacgc aggagccctc 420
ctgctggcct gcatcagctt tgaccgctac ctgaacatag ttcatgccac ccagctctac 480
cgccgggggc ccccggcccg cgtgaccctc acctgcctgg ctgtctgggg gctctgcctg 540
cttttcgccc tcccagactt catcttcctg tcggcccacc acgacgagcg cctcaacgcc 600
acccactgcc aatacaactt cccacagggg tcaagttccg ggagcggatg tggatgctgc 660
tcttgcgcct gggctgcccc aaccagagag ggctccagag gcagccatcg tcttcccgcc 720
gggattcatc ctggtctgag acctcagagg cctcctactc gggcttgtga ggccggaatc 780
cgggctcccc tttcgcccac a 801
<210>110
<211>4503
<212>DNA
<213>人
<400>110
atggatccaa gtatgggtgt gaattctgtt accatttctg ttgagggtat gacttgcaat 60
tcctgtgttt ggaccattga gcagcagatt ggaaaagtga atggtgtgca tcacattaag 120
gtatcactgg aagaaaaaaa tgcaactatt atttatgacc ctaaactaca gactccaaag 180
accctacagg aagctattga tgacatgggc tttgatgctg ttatccataa tcctgaccct 240
ctccctgttt taactgacac cttgtttctg actgttacgg cgtcactgac tttgccatgg 300
gaccatatcc aaagcacatt gctgaagacc aagggtgtga cagacattaa aatttaccct 360
cagaaaagaa ctgtagcagt gacaataatc ccttctatag tgaatgccaa tcagataaaa 420
gagctggttc cagaactcag tttagatact gggacactgg agaaaaagtc aggagcttgt 480
gaagatcata gtatggctca agctggtgaa gtcgtgctga agatgaaagt ggaagggatg 540
acctgccatt catgtactag cactattgaa ggaaaaattg ggaaactgca aggtgttcag 600
cgaattaaag tctccctgga caatcaagaa gctactattg tttatcaacc tcatcttatc 660
tcagtagagg aaatgaaaaa gcagattgaa gctatgggct ttccagcatt tgtcaaaaag 720
cagcccaagt acctcaaatt gggagctatt gatgtagaac gtctaaagaa cacaccagtt 780
aaatcctcag aagggtcaca gcaaaggagt ccatcatata ccaatgattc aacagccact 840
ttcatcattg atggcatgca ttgtaaatca tgtgtgtcaa atattgaaag tactttatct 900
gcactccaat atgtaagcag catagtagtt tctttagaga ataggtctgc cattgtgaag 960
tataatgcaa gctcagtcac tccagaatcc ctgagaaaag caatagaggc tgtatcaccg 1020
gggctatata gagttagtat cacaagtgaa gttgagagta cctcaaactc tccctccagc 1080
tcatctcttc agaagattcc tttgaatgta gttagccagc ctctgacaca agaaactgtg 1140
ataaacattg atggcatgac ttgtaattcc tgtgtgcagt ctattgaggg tgtcatatca 1200
aaaaagccag gtgtaaaatc catacgagtc tcccttgcaa atagcaatgg gactgttgag 1260
tatgatcctc tactaacctc tccagaaacg ttgagaggag caatagaaga catgggattt 1320
gatgctacct tgtcagacac gaatgagccg ttggtagtaa tagctcagcc ttcatcggaa 1380
atgccgcttt tgacttcaac taatgaattt tatactaaag ggatgacacc agttcaagac 1440
aaggaggaag gaaagaattc atctaagtgt tacatacagg tcactggcat gacttgcgct 1500
tcctgtgtag caaacattga acggaattta aggcgggaag aaggaatata ttctatactt 1560
gtggccctga tggctggcaa ggcagaagta aggtataatc ctgctgttat acaaccccca 1620
atgatagcag agttcatccg agaacttgga tttggagcca ctgtgataga aaatgctgat 1680
gaaggagatg gtgttttgga acttgttgtg aggggaatga cgtgtgcctc ctgcgtacat 1740
aaaatagagt ctagtctcac aaaacacaga gggatcctat actgctccgt ggccctggca 1800
accaacaaag cacatattaa atatgaccca gaaattattg gtcctagaga tattatccat 1860
acaattgaaa gcttaggttt tgaagcttct ttggtcaaga aggatcggtc agcaagtcac 1920
ttagatcata aacgagaaat aagacaatgg agacggtctt ttcttgtgag tctgtttttc 1980
tgtattcctg taatggggct gatgatatat atgatggtta tggaccacca ctttgcaact 2040
cttcaccata atcaaaacat gagtaaagaa gaaatgatca accttcattc ttctatgttc 2100
ctggagcgcc agattcttcc aggattgtct gttatgaatt tgctgtcctt tttattgtgt 2160
gtacctgtac agtttttcgg aggctggtac ttctacattc aggcttataa agcactgaag 2220
cataagacag caaatatgga cgtactgatt gtgctggcaa ccaccattgc atttgcctac 2280
tctttgatta ttcttctagt tgcaatgtat gagagagcca aagtgaaccc tattactttc 2340
tttgacacac cccctatgct gtttgtgttt attgcactag gccgatggct ggaacatata 2400
gcaaagggca aaacatcaga ggctcttgca aagttaattt cactacaagc tacagaagca 2460
actattgtaa ctcttgattc tgataatatc ctcctcagtg aagaacaagt ggatgtggaa 2520
cttgtacaac gtggagatat cattaaagta gttccaggag gcaaatttcc agtggatggt 2580
cgtgttattg aaggacattc tatggtagat gagtccctca tcacagggga ggcaatgcct 2640
gtggctaaga aacctggcag cacagtgatt gctggttcca ttaaccagaa cgggtcactg 2700
cttatctgcg caacacatgt tggagcagac acaacccttt ctcaaattgt caaacttgtg 2760
gaagaggcac aaacatcaaa ggctcctatc cagcagtttg cagacaaact cagtggctat 2820
tttgttcctt ttattgtttt tgtttccatt gccaccctct tggtatggat tgtaattgga 2880
tttctgaatt ttgaaattgt ggaaacctac tttcctggct acaatagaag tatctcccga 2940
acagaaacga taatacgatt tgctttccaa gcctctatca cagttctgtg tattgcatgt 3000
ccctgttcac tgggactggc cactccaact gctgtgatgg tgggtacagg agtaggtgct 3060
caaaatggca tactaataaa aggtggagag ccattggaga tggctcataa ggtaaaggta 3120
gtggtatttg ataagactgg aaccattact cacggaaccc cagtggtgaa tcaagtaaag 3180
gttctaactg aaagtaacag aatatcacac cataaaatct tggccattgt gggaactgct 3240
gaaagtaaca gtgaacaccc tctaggaaca gccataacca aatattgcaa acaggagctg 3300
gacactgaaa ccttgggtac ctgcatagat ttccaggttg tgccaggctg tggtattagc 3360
tgtaaagtca ccaatattga aggcttgcta cataagaata actggaatat agaggacaat 3420
aatattaaaa atgcatccct ggttcaaatt gatgccagta atgaacagtc atcaacttcg 3480
tcttccatga ttattgatgc ccagatctca aatgctctta atgctcagca gtataaagtc 3540
ctcattggta accgggagtg gatgattaga aatggtcttg tcattaataa cgatgtaaat 3600
gatttcatga ctgaacatga gagaaaaggt cggactgctg tattagtagc agttgatgat 3660
gagctgtgtg gcttgatagc cattgcagac acagtgaagc ctgaagcaga actggctatc 3720
catattctga aatctatggg cttagaagta gttctgatga ctggagacaa cagtaaaaca 3780
gctagatcta ttgcttctca ggttggcatt actaaggtgt ttgctgaagt tctaccttct 3840
cacaaggttg ctaaagtgaa gcaacttcaa gaggagggga aacgggtagc aatggtggga 3900
gatggaatca atgactcccc agctctggca atggctaatg tgggaattgc tattggcaca 3960
ggcacagatg tagccattga agcagctgat gtggttttga taaggaatga tcttctggat 4020
gtagtggcaa gtattgactt atcaagagag acagtcaaga ggattcggat aaattttgtc 4080
tttgctctaa tttataatct ggttggaatt cccatagctg ctggagtttt tatgcccatt 4140
ggtttggttt tgcagccctg gatgggatct gcagcaatgg ctgcttcatc tgtttctgta 4200
gtactttctt ctctcttcct taaactttac aggaaaccaa cttacgagag ttatgaactg 4260
cctgcccgga gccagatagg acagaagagt ccttcagaaa tcagcgttca tgttggaata 4320
gatgatacct caaggaattc tcctaaactg ggtttgctgg accggattgt taattatagc 4380
agagcctcta taaactcact actgtctgat aaacgctccc taaacagtgt tgttaccagt 4440
gaacctgaca agcactcact cctggtggga gacttcaggg aagatgatga cactgcatta 4500
taa 4503
<210>111
<211>3342
<212>DNA
<213>人
<400>111
atgttccgcc ggagcttgaa tcgtttttgt gctggagaag agaaacgagt tggcacacgc 60
acagtgtttg ttggcaatca tccagtttcg gaaacagaag cttacattgc acaaagattt 120
tgtgataata gaatagtctc atctaagtat acactttgga attttctccc aaagaatctg 180
tttgaacagt ttagaagaat tgcaaatttt tattttctca taatcttcct tgtacaggtc 240
acagtagaca caccaactag cccagttacc agtggacttc cacttttctt tgttataact 300
gttacagcca tcaagcaggg atatgaggat tgtctgagac acagagctga caatgaagtc 360
aacaaaagca ctgtttacat tattgaaaat gcaaagcgag tgagaaaaga aagtgaaaaa 420
atcaaggttg gtgatgtagt agaagtacag gcagatgaaa cctttccctg tgatcttatt 480
cttctatcat cttgcaccac tgatggaacc tgttatgtca ctacagccag tcttgatggg 540
gaatccaatt gcaagacaca ttatgcagta cgtgatacca ttgcactgtg tacagcagaa 600
tccatcgata ccctccgagc agcaattgaa tgtgaacagc ctcaacctga cctctacaaa 660
tttgttgggc gaatcaatat ctacagtaat agtcttgagg ctgttgccag gtctttggga 720
cctgaaaatc tcttgctgaa aggagctacg ctaaaaaata ccgagaagat atatggagtt 780
gctgtttaca ctggaatgga aaccaaaatg gctttgaact accaagggaa atctcagaaa 840
cgttctgctg ttgaaaaatc tattaatgct ttcctgattg tatatttatt tatcttactg 900
accaaagctg cagtatgcac tactctaaag tatgtttggc aaagtacccc atacaatgat 960
gaaccttggt ataaccaaaa gactcagaaa gagcgagaga ccttgaaggt tttaaaaatg 1020
ttcaccgact tcctatcatt tatggttcta ttcaacttta tcattcctgt ctccatgtac 1080
gtcacagtag aaatgcagaa attcttgggc tccttcttca tctcatggga taaggacttt 1140
tatgatgaag aaattaatga aggagccctg gttaacacat cagaccttaa tgaagaactt 1200
ggtcaggtgg attatgtatt tacagataag actggaacac tcactgaaaa cagcatggaa 1260
ttcattgaat gctgcataga tggccacaaa tataaaggtg taactcaaga ggttgatgga 1320
ttatctcaaa ctgatggaac tttaacatat tttgacaaag tagataagaa tcgagaagag 1380
ctgtttctac gtgccttgtg tttatgtcat actgtagaaa tcaaaacaaa cgatgctgtt 1440
gatggagcta cagaatcagc tgaattaacc tatatctcct cttcaccaga tgaaatagct 1500
ttggtgaaag gagctaaaag gtacgggttc acatttttag gaaatcgaaa tggatatatg 1560
agagtagaga accaaagaaa agaaatagaa gaatatgaac ttcttcacac cttaaacttt 1620
gatgctgtcc ggcgacgtat gagtgtaatt gtgaagactc aagaaggaga catacttctc 1680
ttttgtaaag gagcagactc ggcagttttt cccagagtgc aaaatcatga aattgagtta 1740
actaaagtcc atgtggaacg taatgcaatg gatgggtatc ggacactctg tgtagccttc 1800
aaagaaattg ctccagatga ttatgaaaga attaacagac agctcataga ggcaaaaatg 1860
gccttacaag acagagaaga aaaaatggaa aaagttttcg atgatattga gacaaacatg 1920
aatttaattg gagccactgc agttgaagac aagctacaag atcaagctgc agagaccatt 1980
gaagctctgc atgcagcagg cctgaaagtc tgggtgctca ctggggacaa gatggagaca 2040
gctaaatcca catgctatgc ctgccgcctt ttccagacca acactgagct cttagaacta 2100
accacaaaaa ccattgaaga aagtgaaagg aaagaagatc gattacatga attattgata 2160
gaatatcgca agaaattgct gcatgagttt cctaaaagta ctagaagctt taaaaaagca 2220
tggacagaac atcaggaata tggattaatc atagatggct ccacattgtc actcatacta 2280
aattctagtc aagactctag ttcaaacaat tacaaaagca ttttcctaca aatatgtatg 2340
aagtgtactg cagtgctctg ctgtcggatg gcaccattac agaaagccca gattgtcaga 2400
atggtgaaga atttaaaagg cagcccaata actctgtcga taggtgatgg tgccaatgat 2460
gttagtatga tcttggaatc ccatgtggga ataggcaaag aaggtcgcca agcagctagg 2520
aatagcgatt attctgttcc aaagtttaaa cacttaaaga aactgctgtt ggctcatgga 2580
catctatatt atgtgagaat agcacacctt gtacagtact tcttctataa gaacctttgt 2640
ttcattttgc cacagttttt gtaccagttc ttctgtggat tctcacaaca gccactgtat 2700
gatgctgctt accttacaat gtacaatatc tgcttcacat ccttgcccat cctggcctat 2760
agtctactgg aacagcacat caacattgac actctgacct cagatccccg attgtatatg 2820
aaaatttctg gcaatgccat gctacagttg ggccccttct tatattggac atttctggct 2880
gcctttgaag ggacagtgtt cttctttggg acttactttc tttttcagac tgcatcccta 2940
gaagaaaatg gaaaggtata cggaaactgg acttttggaa ccattgtttt tacagtctta 3000
gtattcactg taaccctgaa gcttgccttg gatacccgat tctggacgtg gataaatcac 3060
tttgtgattt ggggttcttt agccttctat gtatttttct cattcttctg gggaggaatt 3120
atttggcctt ttctcaagca acagagaatg tattttgtat ttgcccaaat gctgtcttct 3180
gtatccacat ggttggctat aattcttcta atatttatca gcctgttccc tgagattctt 3240
ctgatagtat taaagaatgt aagaagaaga agtgccagga atccgaatct tgaactgcct 3300
atgttattgt cctacaagca tactgacagt ggttacagct aa 3342
<210>112
<211>1248
<212>DNA
<213>人
<400>112
atggagttga ggaagtacgg ccctggaaga ctggcgggga cagttatagg aggagctgct 60
cagagtaaat cacagactaa atcagactca atcacaaaag agttcctgcc aggcctttac 120
acagcccctt cctccccgtt cccgccctca caggtgagtg accaccaagt gctaaatgac 180
gccgaggttg ccgccctcct ggagaacttc agctcttcct atgactatgg agaaaacgag 240
agtgactcgt gctgtacctc cccgccctgc ccacaggact tcagcctgaa cttcgaccgg 300
gccttcctgc cagccctcta cagcctcctc tttctgctgg ggctgctggg caacggcgcg 360
gtggcagccg tgctgctgag ccggcggaca gccctgagca gcaccgacac cttcctgctc 420
cacctagctg tagcagacac gctgctggtg ctgacactgc cgctctgggc agtggacgct 480
gccgtccagt gggtctttgg ctctggcctc tgcaaagtgg caggtgccct cttcaacatc 540
aacttctacg caggagccct cctgctggcc tgcatcagct ttgaccgcta cctgaacata 600
gttcatgcca cccagctcta ccgccggggg cccccggccc gcgtgaccct cacctgcctg 660
gctgtctggg ggctctgcct gcttttcgcc ctcccagact tcatcttcct gtcggcccac 720
cacgacgagc gcctcaacgc cacccactgc caatacaact tcccacaggt gggccgcacg 780
gctctgcggg tgctgcagct ggtggctggc tttctgctgc ccctgctggt catggcctac 840
tgctatgccc acatcctggc cgtgctgctg gtttccaggg gccagcggcg cctgcgggcc 900
atgcggctgg tggtggtggt cgtggtggcc tttgccctct gctggacccc ctatcacctg 960
gtggtgctgg tggacatcct catggacctg ggcgctttgg cccgcaactg tggccgagaa 1020
agcagggtag acgtggccaa gtcggtcacc tcaggcctgg gctacatgca ctgctgcctc 1080
aacccgctgc tctatgcctt tgtaggggtc aagttccggg agcggatgtg gatgctgctc 1140
ttgcgcctgg gctgccccaa ccagagaggg ctccagaggc agccatcgtc ttcccgccgg 1200
gattcatcct ggtctgagac ctcagaggcc tcctactcgg gcttgtga 1248
<210>113
<211>768
<212>DNA
<213>人
<400>113
atgtcttcac ataggaggaa agcgaagggg aggaatagga gaagtcaccg tgccatgcgt 60
gtggctcact tagagctggc aacttatgag ttggcggcaa ctgagtcgaa tcccgagagc 120
agccatcctg gatacgaggc cgccatggct gacaggcctc agccaggatg gcgggaatct 180
ctaaagatgc gggtcagcaa accctttggg atgctcatgc tctccatttg gatcctgctg 240
ttcgtgtgct actacctgtc ctactacctg tgctccgggt cctcatattt tgtgcttgca 300
aatggacata tcctgcccaa cagtgaaaat gctcatggcc aatctctgga agaagattcc 360
gcattggaag ctttgctgaa ttttttcttt ccaacaactt gcaatctgag ggaaaatcag 420
gtggcaaagc cttgtaatga gctgcaagat cttagtgaga gtgaatgttt gagacacaaa 480
tgctgttttt catcatcggg gaccacgagc ttcaaatgtt ttgctccatt tagagatgtg 540
cctaaacaga tgatgcaaat gtttgggctt ggtgcgatca gccttatcct ggtatgtctg 600
cccatttatt gccgctctct tttctggagg agcgaaccgg ccgatgattt acaaaggcag 660
gacaacagag ttgtaacggg tttgaagaaa caaagaagga agcgaaagag gaagtctgaa 720
atgttacaga aagcagcaag aggacgtgag gaacatggtg acgagtag 768
<210>114
<211>3387
<212>DNA
<213>人
<400>114
atgcagatgg tcccatctct ccctccagcc tctgagtgtg ctggagaaga gaaacgagtt 60
ggcacacgca cagtgtttgt tggcaatcat ccagtttcgg aaacagaagc ttacattgca 120
caaagatttt gtgataatag aatagtctca tctaagtata cactttggaa ttttctccca 180
aagaatctgt ttgaacagtt tagaagaatt gcaaattttt attttctcat aatcttcctt 240
gtacaggtca cagtagacac accaactagc ccagttacca gtggacttcc acttttcttt 300
gttataactg ttacagccat caagcaggga tatgaggatt gtctgagaca cagagctgac 360
aatgaagtca acaaaagcac tgtttacatt attgaaaatg caaagcgagt gagaaaagaa 420
agtgaaaaaa tcaaggttgg tgatgtagta gaagtacagg cagatgaaac ctttccctgt 480
gatcttattc ttctatcatc ttgcaccact gatggaacct gttatgtcac tacagccagt 540
cttgatgggg aatccaattg caagacacat tatgcagtac gtgataccat tgcactgtgt 600
acagcagaat ccatcgatac cctccgagca gcaattgaat gtgaacagcc tcaacctgac 660
ctctacaaat ttgttgggcg aatcaatatc tacagtaata gtcttgaggc tgttgccagg 720
tctttgggac ctgaaaatct cttgctgaaa ggagctacgc taaaaaatac cgagaagata 780
tatggagttg ctgtttacac tggaatggaa accaaaatgg ctttgaacta ccaagggaaa 840
tctcagaaac gttctgctgt tgaaaaatct attaatgctt tcctgattgt atatttattt 900
atcttactga ccaaagctgc agtatgcact actctaaagt atgtttggca aagtacccca 960
tacaatgatg aaccttggta taaccaaaag actcagaaag agcgagagac cttgaaggtt 1020
ttaaaaatgt tcaccgactt cctatcattt atggttctat tcaactttat cattcctgtc 1080
tccatgtacg tcacagtaga aatgcagaaa ttcttgggct ccttcttcat ctcatgggat 1140
aaggactttt atgatgaaga aattaatgaa ggagccctgg ttaacacatc agaccttaat 1200
gaagaacttg gtcaggtgga ttatgtattt acagataaga ctggaacact cactgaaaac 1260
agcatggaat tcattgaatg ctgcatagat ggccacaaat ataaaggtgt aactcaagag 1320
gttgatggat tatctcaaac tgatggaact ttaacatatt ttgacaaagt agataagaat 1380
cgagaagagc tgtttctacg tgccttgtgt ttatgtcata ctgtagaaat caaaacaaac 1440
gatgctgttg atggagctac agaatcagct gaattaacct atatctcctc ttcaccagat 1500
gaaatagctt tggtgaaagg agctaaaagg tacgggttca catttttagg aaatcgaaat 1560
ggatatatga gagtagagaa ccaaagaaaa gaaatagaag aatatgaact tcttcacacc 1620
ttaaactttg atgctgtccg gcgacgtatg agtgtaattg tgaagactca agaaggagac 1680
atacttctct tttgtaaagg agcagactcg gcagtttttc ccagagtgca aaatcatgaa 1740
attgagttaa ctaaagtcca tgtggaacgt aatgcaatgg atgggtatcg gacactctgt 1800
gtagccttca aagaaattgc tccagatgat tatgaaagaa ttaacagaca gctcatagag 1860
gcaaaaatgg ccttacaaga cagagaagaa aaaatggaaa aagttttcga tgatattgag 1920
acaaacatga atttaattgg agccactgca gttgaagaca agctacaaga tcaagctgca 1980
gagaccattg aagctctgca tgcagcaggc ctgaaagtct gggtgctcac tggggacaag 2040
atggagacag ctaaatccac atgctatgcc tgccgccttt tccagaccaa cactgagctc 2100
ttagaactaa ccacaaaaac cattgaagaa agtgaaagga aagaagatcg attacatgaa 2160
ttattgatag aatatcgcaa gaaattgctg catgagtttc ctaaaagtac tagaagcttt 2220
aaaaaagcat ggacagaaca tcaggaatat ggattaatca tagatggctc cacattgtca 2280
ctcatactaa attctagtca agactctagt tcaaacaatt acaaaagcat tttcctacaa 2340
atatgtatga agtgtactgc agtgctctgc tgtcggatgg caccattaca gaaagcccag 2400
attgtcagaa tggtgaagaa tttaaaaggc agcccaataa ctctgtcgat aggtgatggt 2460
gccaatgatg ttagtatgat cttggaatcc catgtgggaa taggtattaa aggcaaagaa 2520
ggtcgccaag cagctaggaa tagcgattat tctgttccaa agtttaaaca cttaaagaaa 2580
ctgctgttgg ctcatggaca tctatattat gtgagaatag cacaccttgt acagtacttc 2640
ttctataaga acctttgttt cattttgcca cagtttttgt accagttctt ctgtggattc 2700
tcacaacagc cactgtatga tgctgcttac cttacaatgt acaatatctg cttcacatcc 2760
ttgcccatcc tggcctatag tctactggaa cagcacatca acattgacac tctgacctca 2820
gatccccgat tgtatatgaa aatttctggc aatgccatgc tacagttggg ccccttctta 2880
tattggacat ttctggctgc ctttgaaggg acagtgttct tctttgggac ttactttctt 2940
tttcagactg catccctaga agaaaatgga aaggtatacg gaaactggac ttttggaacc 3000
attgttttta cagtcttagt attcactgta accctgaagc ttgccttgga tacccgattc 3060
tggacgtgga taaatcactt tgtgatttgg ggttctttag ccttctatgt atttttctca 3120
ttcttctggg gaggaattat ttggcctttt ctcaagcaac agagaatgta ttttgtattt 3180
gcccaaatgc tgtcttctgt atccacatgg ttggctataa ttcttctaat atttatcagc 3240
ctgttccctg agattcttct gatagtatta aagaatgtaa gaagaagaag tgccagggta 3300
acgaaacgcc tcccttcctc aggaacatct gctatcttca tgctttctca aacttccagc 3360
aatcacagtt tctcttggag tgaataa 3387
<210>115
<211>3360
<212>DNA
<213>人
<400>115
atgcagatgg tcccatctct ccctccagcc tctgagtgtg ctggagaaga gaaacgagtt 60
ggcacacgca cagtgtttgt tggcaatcat ccagtttcgg aaacagaagc ttacattgca 120
caaagatttt gtgataatag aatagtctca tctaagtata cactttggaa ttttctccca 180
aagaatctgt ttgaacagtt tagaagaatt gcaaattttt attttctcat aatcttcctt 240
gtacaggtca cagtagacac accaactagc ccagttacca gtggacttcc acttttcttt 300
gttataactg ttacagccat caagcaggga tatgaggatt gtctgagaca cagagctgac 360
aatgaagtca acaaaagcac tgtttacatt attgaaaatg caaagcgagt gagaaaagaa 420
agtgaaaaaa tcaaggttgg tgatgtagta gaagtacagg cagatgaaac ctttccctgt 480
gatcttattc ttctatcatc ttgcaccact gatggaacct gttatgtcac tacagccagt 540
cttgatgggg aatccaattg caagacacat tatgcagtac gtgataccat tgcactgtgt 600
acagcagaat ccatcgatac cctccgagca gcaattgaat gtgaacagcc tcaacctgac 660
ctctacaaat ttgttgggcg aatcaatatc tacagtaata gtcttgaggc tgttgccagg 720
tctttgggac ctgaaaatct cttgctgaaa ggagctacgc taaaaaatac cgagaagata 780
tatggagttg ctgtttacac tggaatggaa accaaaatgg ctttgaacta ccaagggaaa 840
tctcagaaac gttctgctgt tgaaaaatct attaatgctt tcctgattgt atatttattt 900
atcttactga ccaaagctgc agtatgcact actctaaagt atgtttggca aagtacccca 960
tacaatgatg aaccttggta taaccaaaag actcagaaag agcgagagac cttgaaggtt 1020
ttaaaaatgt tcaccgactt cctatcattt atggttctat tcaactttat cattcctgtc 1080
tccatgtacg tcacagtaga aatgcagaaa ttcttgggct ccttcttcat ctcatgggat 1140
aaggactttt atgatgaaga aattaatgaa ggagccctgg ttaacacatc agaccttaat 1200
gaagaacttg gtcaggtgga ttatgtattt acagataaga ctggaacact cactgaaaac 1260
agcatggaat tcattgaatg ctgcatagat ggccacaaat ataaaggtgt aactcaagag 1320
gttgatggat tatctcaaac tgatggaact ttaacatatt ttgacaaagt agataagaat 1380
cgagaagagc tgtttctacg tgccttgtgt ttatgtcata ctgtagaaat caaaacaaac 1440
gatgctgttg atggagctac agaatcagct gaattaacct atatctcctc ttcaccagat 1500
gaaatagctt tggtgaaagg agctaaaagg tacgggttca catttttagg aaatcgaaat 1560
ggatatatga gagtagagaa ccaaagaaaa gaaatagaag aatatgaact tcttcacacc 1620
ttaaactttg atgctgtccg gcgacgtatg agtgtaattg tgaagactca agaaggagac 1680
atacttctct tttgtaaagg agcagactcg gcagtttttc ccagagtgca aaatcatgaa 1740
attgagttaa ctaaagtcca tgtggaacgt aatgcaatgg atgggtatcg gacactctgt 1800
gtagccttca aagaaattgc tccagatgat tatgaaagaa ttaacagaca gctcatagag 1860
gcaaaaatgg ccttacaaga cagagaagaa aaaatggaaa aagttttcga tgatattgag 1920
acaaacatga atttaattgg agccactgca gttgaagaca agctacaaga tcaagctgca 1980
gagaccattg aagctctgca tgcagcaggc ctgaaagtct gggtgctcac tggggacaag 2040
atggagacag ctaaatccac atgctatgcc tgccgccttt tccagaccaa cactgagctc 2100
ttagaactaa ccacaaaaac cattgaagaa agtgaaagga aagaagatcg attacatgaa 2160
ttattgatag aatatcgcaa gaaattgctg catgagtttc ctaaaagtac tagaagcttt 2220
aaaaaagcat ggacagaaca tcaggaatat ggattaatca tagatggctc cacattgtca 2280
ctcatactaa attctagtca agactctagt tcaaacaatt acaaaagcat tttcctacaa 2340
atatgtatga agtgtactgc agtgctctgc tgtcggatgg caccattaca gaaagcccag 2400
attgtcagaa tggtgaagaa tttaaaaggc agcccaataa ctctgtcgat aggtgatggt 2460
gccaatgatg ttagtatgat cttggaatcc catgtgggaa taggtattaa aggcaaagaa 2520
ggtcgccaag cagctaggaa tagcgattat tctgttccaa agtttaaaca cttaaagaaa 2580
ctgctgttgg ctcatggaca tctatattat gtgagaatag cacaccttgt acagtacttc 2640
ttctataaga acctttgttt cattttgcca cagtttttgt accagttctt ctgtggattc 2700
tcacaacagc cactgtatga tgctgcttac cttacaatgt acaatatctg cttcacatcc 2760
ttgcccatcc tggcctatag tctactggaa cagcacatca acattgacac tctgacctca 2820
gatccccgat tgtatatgaa aatttctggc aatgccatgc tacagttggg ccccttctta 2880
tattggacat ttctggctgc ctttgaaggg acagtgttct tctttgggac ttactttctt 2940
tttcagactg catccctaga agaaaatgga aaggtatacg gaaactggac ttttggaacc 3000
attgttttta cagtcttagt attcactgta accctgaagc ttgccttgga tacccgattc 3060
tggacgtgga taaatcactt tgtgatttgg ggttctttag ccttctatgt atttttctca 3120
ttcttctggg gaggaattat ttggcctttt ctcaagcaac agagaatgta ttttgtattt 3180
gcccaaatgc tgtcttctgt atccacatgg ttggctataa ttcttctaat atttatcagc 3240
ctgttccctg agattcttct gatagtatta aagaatgtaa gaagaagaag tgccaggaat 3300
ccgaatcttg aactgcctat gttattgtcc tacaagcata ctgacagtgg ttacagctaa 3360
<210>116
<211>219
<212>DNA
<213>人
<400>116
atgatgcaaa tgtttgggct tggtgcgatc agccttatcc tggtatgtct gcccatttat 60
tgccgctctc ttttctggag gagcgaaccg gccgatgatt tacaaaggca ggacaacaga 120
gttgtaacgg gtttgaagaa acaaagaagg aagcgaaaga ggaagtctga aatgttacag 180
aaagcagcaa gaggacgtga ggaacatggt gacgagtag 219
<210>117
<211>1053
<212>DNA
<213>人
<400>117
atgaacctga ggggcctctt ccaggacttc aacccgagta aattcctcat ctatgcctgt 60
ctgctgctgt tctctgtgct gctggccctt cgtttggatg gcatcataca gtggagttac 120
tgggctgtct ttgctccaat atggctgtgg aagttaatgg tcattgttgg agcctcagtt 180
ggaactggag tctgggcacg aaatcctcaa tatcgagcag aaggagaaac gtgtgtggag 240
tttaaagcca tgttgattgc agtgggcatc cacttgctct tgttgatgtt tgaagttctg 300
gtctgtgaca gaatcgagag aggaagccat ttctggctcc tggtcttcat gccgctgttc 360
tttgtttccc cggtgtctgt tgcagcttgc gtttggggct ttcgacatga caggtcacta 420
gagttagaaa tcctgtgttc tgtcaacatt ctccagttta tattcattgc cttaagactg 480
gacaagatca tccactggcc ctggcttgtt gtgtgtgtcc cgctgtggat tctcatgtcc 540
tttctgtgcc tggtggtcct ctactacatt gtgtggtccg tcttgttctt gcgctctatg 600
gatgtgattg cggagcagcg caggacacac ataaccatgg ccctgagctg gatgaccatc 660
gtcgtgcccc ttcttacatt tgagattctg ctggttcaca aactggatgg ccacaacgcc 720
ttctcctgca tcccgatctt tgtccccctt tggctctcgt tgatcacgct gatggcaacc 780
acatttggac agaagggagg aaaccactgg tggtttggta tccgcaaaga tttctgtcag 840
tttctgcttg aaatcttccc atttctacga gaatatggaa acatttccta tgatctccat 900
cacgaagata atgaagaaac cgaagagacc ccagttccgg agccccctaa aatcgcaccc 960
atgtttcgaa agaaggccag ggtggtcatt acccagagcc ctgggaagta tgtgctccca 1020
cctcccaaat taaatatcga aatgccagat tag 1053
<210>118
<211>471
<212>DNA
<213>人
<400>118
atgctcgggt ctccttgcgg cccccagctc agcgaccgag acgcagacga ggaccagtgt 60
tcacgcgagt tcagggggcg gcgtagccgc cgcccgccca ggaggaccat gttgcgcggc 120
aagtcccggc tcaacgtgga gtggctgggc tactcgccag gcctgctcct cgagcacagg 180
cccctcctgg cagggcgcac gccgcggagc caccgccgaa atgaaagctc attagcatct 240
acactgaaga cgctcctgtt cttcacagct ttaatgatca ctgttcctat tgggttatat 300
ttcacaacta aatcttacat atttgaaggc gcccttggga tgtccaatag ggacagctat 360
ttttacgctg ctattgttgc agtggtcgcc gtccatgtgg tgctggccct ctttgtgtat 420
gtggcctgga atgaaggctc acgacagtgg cgtgaaggca aacaggatta a 471
<210>119
<211>1908
<212>DNA
<213>人
<400>119
atggcgaaga agagcgccga gaacggcatc tatagcgtgt ccggcgacga gaagaagggc 60
cccctcatcg cgcccgggcc cgacggggcc ccggccaagg gcgacggccc cgtgggcctg 120
gggacacccg gcggccgcct ggccgtgccg ccgcgcgaga cctggacgcg ccagatggac 180
ttcatcatgt cgtgcgtggg cttcgccgtg ggcttgggca acgtgtggcg cttcccctac 240
ctgtgctaca agaacggcgg aggtgtgttc cttattccct acgtcctgat cgccctggtt 300
ggaggaatcc ccattttctt cttagagatc tcgctgggcc agttcatgaa ggccggcagc 360
atcaatgtct ggaacatctg tcccctgttc aaaggcctgg gctacgcctc catggtgatc 420
gtcttctact gcaacaccta ctacatcatg gtgctggcct ggggcttcta ttacctggtc 480
aagtccttta ccaccacgct gccctgggcc acatgtggcc acacctggaa cactcccgac 540
tgcgtggaga tcttccgcca tgaagactgt gccaatgcca gcctggccaa cctcacctgt 600
gaccagcttg ctgaccgccg gtcccctgtc atcgagttct gggagaacaa agtcttgagg 660
ctgtctgggg gactggaggt gccaggggcc ctcaactggg aggtgaccct ttgtctgctg 720
gcctgctggg tgctggtcta cttctgtgtc tggaaggggg tcaaatccac gggaaagatc 780
gtgtacttca ctgctacatt cccctacgtg gtcctggtcg tgctgctggt gcgtggagtg 840
ctgctgcctg gcgccctgga tggcatcatt tactatctca agcctgactg gtcaaagctg 900
gggtcccctc aggtgtggat agatgcgggg acccagattt tcttttctta cgccattggc 960
ctgggggccc tcacagccct gggcagctac aaccgcttca acaacaactg ctacaaggac 1020
gccatcatcc tggctctcat caacagtggg accagcttct ttgctggctt cgtggtcttc 1080
tccatcctgg gcttcatggc tgcagagcag ggcgtgcaca tctccaaggt ggcagagtca 1140
gggccgggcc tggccttcat cgcctacccg cgggctgtca cgctgatgcc agtggcccca 1200
ctctgggctg ccctgttctt cttcatgctg ttgctgcttg gtctcgacag ccagtttgta 1260
ggtgtggagg gcttcatcac cggcctcctc gacctcctcc cggcctccta ctacttccgt 1320
ttccaaaggg agatctctgt ggccctctgt tgtgccctct gctttgtcat cgatctctcc 1380
atggtgactg atggcgggat gtacgtcttc cagctgtttg actactactc ggccagcggc 1440
accaccctgc tctggcaggc cttttgggag tgcgtggtgg tggcctgggt gtacggagct 1500
gaccgcttca tggacgacat tgcctgtatg atcgggtacc gaccttgccc ctggatgaaa 1560
tggtgctggt ccttcttcac cccgctggtc tgcatgggca tcttcatctt caacgttgtg 1620
tactacgagc cgctggtcta caacaacacc tacgtgtacc cgtggtgggg tgaggccatg 1680
ggctgggcct tcgccctgtc ctccatgctg tgcgtgccgc tgcacctcct gggctgcctc 1740
ctcagggcca agggcaccat ggctgagcgc tggcagcacc tgacccagcc catctggggc 1800
ctccaccact tggagtaccg agctcaggac gcagatgtca ggggcctgac caccctgacc 1860
ccagtgtccg agagcagcaa ggtcgtcgtg gtggagagtg tcatgtga 1908
<210>120
<211>3663
<212>DNA
<213>人
<400>120
atgggcgaca tggccaatag ttccatcgag ttccacccca agccccagca gcagcgggat 60
gtcccccagg ctggaggctt tgggtgcacg ctggcggagc tgcgcaccct catggagctg 120
cgaggggccg aggcgctgca gaagatcgag gaggcctacg gggatgtcag cgggctctgc 180
cggaggctga agacctcacc cacagagggc ctggcggaca acaccaatga cctggagaag 240
cgcaggcaga tctacgggca gaacttcatc cccccaaagc aacccaagac cttcctgcag 300
ctggtgtggg aggccctgca ggacgtgacc ctcatcatcc tggaggtggc tgccatcgtc 360
tctctgggcc tctcgttcta tgcgccgcca ggagaggaga gtgaagcctg tgggaatgtg 420
tcgggaggcg cagaagatga gggcgaggcc gaagctggct ggatcgaggg ggctgccatc 480
ctgctgtccg tcatctgtgt ggtgctggtc acggccttca atgactggag caaggagaag 540
cagttccgag gcctgcagag ccgaattgag caggagcaga agttcacggt catccggaac 600
gggcagctcc tccaggtccc cgtggctgcg ctggtggtgg gggacattgc ccaggtcaag 660
tacggcgacc tgctgccagc cgacggcgtg ctcatccagg ccaatgacct caagatcgac 720
gagagctccc tgacgggcga gtctgaccac gtgcgcaagt cagctgacaa agatcccatg 780
ctgctctcag gcactcatgt catggaaggt tctggaagaa tggtggtgac cgccgttggc 840
gtgaattccc agacaggcat catcttcacg ctgcttggag ctggcggaga ggaggaagag 900
aagaaagata agaaaggcaa gcagcaggat ggggccatgg agagtagcca gaccaaagct 960
aagaagcagg atggtgcagt ggccatggag atgcagcccc tgaagagcgc ggagggtggg 1020
gagatggagg agcgggagaa gaagaaagcc aacgcaccca aaaaggagaa gtctgtcctt 1080
caggggaagc tcacaaagct agccgtgcag atcgggaaag cagggctggt gatgtctgcc 1140
atcaccgtca tcatcctggt cctctacttt gtgattgaga cgtttgtcgt ggaaggccgg 1200
acatggctgg cagagtgcac gccggtctat gtacaatact tcgtgaagtt cttcatcatt 1260
ggtgtcactg tgctggtcgt ggctgtccca gagggcctgc ctcttgctgt caccatctcc 1320
ttagcttact ctgtcaagaa aatgatgaaa gacaacaacc tggtgcgcca cctggatgcc 1380
tgcgagacca tgggcaacgc cacagccatc tgctccgaca agacgggcac gctcaccacc 1440
aaccgtatga ccgtggtcca gtcctaccta ggagacaccc actacaaaga gattccggcc 1500
cccagcgccc tgacccctaa gatcctcgac ctcctggtcc atgccatctc catcaacagt 1560
gcctatacca ccaaaatact acctcctgag aaggaaggcg ccctcccacg ccaggtgggc 1620
aataagacgg agtgcgccct gctgggcttc gtcttggacc tgaagcggga cttccagccc 1680
gtgcgcgagc agatcccgga agacaagctt tacaaagtgt acaccttcaa ctcggtccgc 1740
aagtccatga gcacagtcat ccgcatgccc gacggtggct tccgcctctt cagcaagggg 1800
gcctcagaga tcctcttgaa aaagtgcacc aacatcttga acagcaatgg cgaactccgg 1860
ggctttcggc ctcgggaccg ggacgacatg gtgaggaaga tcatcgagcc gatggcttgc 1920
gatggcctcc gcaccatctg catcgcctac cgggacttct ctgcaggcca ggagcccgac 1980
tgggacaacg agaatgaggt cgtgggtgac ctcacctgca tagctgtcgt gggcattgag 2040
gaccctgtgc ggcccgaggt ccctgaagct atccgaaaat gccagcgtgc tggcatcaca 2100
gtccgcatgg tgactgggga caacatcaac acggcccggg ccatcgcagc caaatgcggc 2160
atcatccagc ccggggagga cttcctgtgc ctagaaggga aggagttcaa ccggcggatc 2220
cgcaatgaga aaggcgagat agaacaggag cggctggaca aggtgtggcc caagctgagg 2280
gtgctggccc ggtcgtctcc caccgacaag cacacactgg tcaaagggat tatcgacagc 2340
accactggtg agcagcggca ggtggtggct gtgacagggg atggcaccaa cgatgggccg 2400
gccctcaaga aggcggacgt gggcttcgcc atgggcatcg cagggaccga cgtggccaag 2460
gaggcctccg acatcatcct gaccgatgac aacttcacca gcatcgtcaa ggcagtcatg 2520
tggggccgta acgtctatga cagcatctcc aagttcctgc agtttcaact gacggtcaat 2580
gtggtggctg tgatcgtggc cttcacaggt gcctgcatta ctcaggactc tcctctcaaa 2640
gccgtgcaga tgttgtgggt gaacttgatc atggacacat ttgcctctct ggccctggcg 2700
acggagccac ccacagagtc gctgctgctg cggaagccgt acggccgcga caagcccctc 2760
atctcccgca ccatgatgaa gaacattctg ggccacgccg tgtaccagct cgccatcatc 2820
ttcaccctgc tgtttgtcgg ggagctcttc ttcgacatcg acagcgggag gaatgcgccc 2880
ctgcactcgc caccctcaga gcactacacc atcatcttca acacgttcgt catgatgcag 2940
ctctttaacg agatcaacgc ccgcaagatc cacggcgaga ggaacgtgtt cgacggcatc 3000
ttcagcaacc ccatcttctg caccatcgtt ttgggcactt tcgggattca gattgtcatc 3060
gtccagtttg gcgggaagcc cttcagctgc tccccactat ccacagaaca gtggctctgg 3120
tgcctgtttg ttggtgttgg ggagctggtc tggggacagg tcattgccac catccccacc 3180
agccagctca agtgcctgaa ggaagccggg cacgggcccg ggaaggacga gatgaccgac 3240
gaggagctgg ccgaaggcga ggaagagatc gaccatgccg agcgggagct ccgcaggggc 3300
cagatcctct ggttccgggg cctgaaccgg attcagacgc agatccgggt ggtgaaagcg 3360
ttccgtagct cgctctatga aggcctggag aaaccagaat ccaagacctc cattcacaac 3420
ttcatggcca cgcccgagtt tctgatcaat gactacaccc acaacatccc gctcattgac 3480
gacacggacg tggacgagaa cgaggagcgc ctccgggccc ccccgccccc gtcccccaac 3540
cagaacaaca acgccataga cagcggcatc tacctgacca cgcatgtcac caagtcagct 3600
acctcttcag tgttttcctc cagtcccggg agcccgctcc acagcgtgga gacgtccctc 3660
taa 3663
<210>121
<211>1908
<212>DNA
<213>人
<400>121
atggcgaaga agagcgccga gaacggcatc tatagcgtgt ccggcgacga gaagaagggc 60
cccctcatcg cgcccgggcc cgacggggcc ccggccaagg gcgacggccc cgtgggcctg 120
gggacacccg gcggccgcct ggccgtgccg ccgcgcgaga cctggacgcg ccagatggac 180
ttcatcatgt cgtgcgtggg cttcgccgtg ggcttgggca acgtgtggcg cttcccctac 240
ctgtgctaca agaacggcgg aggtgtgttc cttattccct acgtcctgat cgccctggtt 300
ggaggaatcc ccattttctt cttagagatc tcgctgggcc agttcatgaa ggccggcagc 360
atcaatgtct ggaacatctg tcccctgttc aaaggcctgg gctacgcctc catggtgatc 420
gtcttctact gcaacaccta ctacatcatg gtgctggcct ggggcttcta ttacctggtc 480
aagtccttta ccaccacgct gccctgggcc acatgtggcc acacctggaa cactcccgac 540
tgcgtggaga tcttccgcca tgaagactgt gccaatgcca gcctggccaa cctcacctgt 600
gaccagcttg ctgaccgccg gtcccctgtc atcgagttct gggagaacaa agtcttgagg 660
ctgtctgggg gactggaggt gccaggggcc ctcaactggg aggtgaccct ttgtctgctg 720
gcctgctggg tgctggtcta cttctgtgtc tggaaggggg tcaaatccac gggaaagatc 780
gtgtacttca ctgctacatt cccctacgtg gtcctggtcg tgctgctggt gcgtggagtg 840
ctgctgcctg gcgccctgga tggcatcatt tactatctca agcctgactg gtcaaagctg 900
gggtcccctc aggtgtggat agatgcgggg acccagattt tcttttctta cgccattggc 960
ctgggggccc tcacagccct gggcagctac aaccgcttca acaacaactg ctacaaggac 1020
gccatcatcc tggctctcat caacagtggg accagcttct ttgctggctt cgtggtcttc 1080
tccatcctgg gcttcatggc tgcagagcag ggcgtgcaca tctccaaggt ggcagagtca 1140
gggccgggcc tggccttcat cgcctacccg cgggctgtca cgctgatgcc agtggcccca 1200
ctctgggctg ccctgttctt cttcatgctg ttgctgcttg gtctcgacag ccagtttgta 1260
ggtgtggagg gcttcatcac cggcctcctc gacctcctcc cggcctccta ctacttccgt 1320
ttccaaaggg agatctctgt ggccctctgt tgtgccctct gctttgtcat cgatctctcc 1380
atggtgactg atggcgggat gtacgtcttc cagctgtttg actactactc ggccagcggc 1440
accaccctgc tctggcaggc cttttgggag tgcgtggtgg tggcctgggt gtacggagct 1500
gaccgcttca tggacgacat tgcctgtatg atcgggtacc gaccttgccc ctggatgaaa 1560
tggtgctggt ccttcttcac cccgctggtc tgcatgggca tcttcatctt caacgttgtg 1620
tactacgagc cgctggtcta caacaacacc tacgtgtacc cgtggtgggg tgaggccatg 1680
ggctgggcct tcgccctgtc ctccatgctg tgcgtgccgc tgcacctcct gggctgcctc 1740
ctcagggcca agggcaccat ggctgagcgc tggcagcacc tgacccagcc catctggggc 1800
ctccaccact tggagtaccg agctcaggac gcagatgtca ggggcctgac caccctgacc 1860
ccagtgtccg agagcagcaa ggtcgtcgtg gtggagagtg tcatgtga 1908
<210>122
<211>3480
<212>DNA
<213>人
<400>122
atgggcgaca tggccaatag ttccatcgag ttccacccca agccccagca gcagcgggat 60
gtcccccagg ctggaggctt tgggtgcacg ctggcggagc tgcgcaccct catggagctg 120
cgaggggccg aggcgctgca gaagatcgag gaggcctacg gggatgtcag cgggctctgc 180
cggaggctga agacctcacc cacagagggc ctggcggaca acaccaatga cctggagaag 240
cgcaggcaga tctacgggca gaacttcatc cccccaaagc aacccaagac cttcctgcag 300
ctggtgtggg aggccctgca ggacgtgacc ctcatcatcc tggaggtggc tgccatcgtc 360
tctctgggcc tctcgttcta tgcgccgcca ggagaggaga gtgaagcctg tgggaatgtg 420
tcgggaggcg cagaagatga gggcgaggcc gaagctggct ggatcgaggg ggctgccatc 480
ctgctgtccg tcatctgtgt ggtgctggtc acggccttca atgactggag caaggagaag 540
cagttccgag gcctgcagag ccgaattgag caggagcaga agttcacggt catccggaac 600
gggcagctcc tccaggtccc cgtggctgcg ctggtggtgg gggacattgc ccaggtcaag 660
tacggcgacc tgctgccagc cgacggcgtg ctcatccagg ccaatgacct caagatcgac 720
gagagctccc tgacgggcga gtctgaccac gtgcgcaagt cagctgacaa agatcccatg 780
ctgctctcag gcactcatgt catggaaggt tctggaagaa tggtggtgac cgccgttggc 840
gtgaattccc agacaggcat catcttcacg ctgcttggag ctggcggaga ggaggaagag 900
aagaaagata agaaagctaa gaagcaggat ggtgcagtgg ccatggagat gcagcccctg 960
aagagcgcgg agggtgggga gatggaggag cgggagaaga agaaagccaa cgcacccaaa 1020
aaggagaagt ctgtccttca ggggaagctc acaaagctag ccgtgcagat cgggaaagca 1080
gggctggtga tgtctgccat caccgtcatc atcctggtcc tctactttgt gattgagacg 1140
tttgtcgtgg aaggccggac atggctggca gagtgcacgc cggtctatgt acaatacttc 1200
gtgaagttct tcatcattgg tgtcactgtg ctggtcgtgg ctgtcccaga gggcctgcct 1260
cttgctgtca ccatctcctt agcttactct gtcaagaaaa tgatgaaaga caacaacctg 1320
gtgcgccacc tggatgcctg cgagaccatg ggcaacgcca cagccatctg ctccgacaag 1380
acgggcacgc tcaccaccaa ccgtatgacc gtggtccagt cctacctagg agacacccac 1440
tacaaagaga ttccggcccc cagcgccctg acccctaaga tcctcgacct cctggtccat 1500
gccatctcca tcaacagtgc ctataccacc aaaatactac ctcctgagaa ggaaggcgcc 1560
ctcccacgcc aggtgggcaa taagacggag tgcgccctgc tgggcttcgt cttggacctg 1620
aagcgggact tccagcccgt gcgcgagcag atcccggaag acaagcttta caaagtgtac 1680
accttcaact cggtccgcaa gtccatgagc acagtcatcc gcatgcccga cggtggcttc 1740
cgcctcttca gcaagggggc ctcagagatc ctcttgaaaa agtgcaccaa catcttgaac 1800
agcaatggcg aactccgggg ctttcggcct cgggaccggg acgacatggt gaggaagatc 1860
atcgagccga tggcttgcga tggcctccgc accatctgca tcgcctaccg ggacttctct 1920
gcaggccagg agcccgactg ggacaacgag aatgaggtcg tgggtgacct cacctgcata 1980
gctgtcgtgg gcattgagga ccctgtgcgg cccgaggtcc ctgaagctat ccgaaaatgc 2040
cagcgtgctg gcatcacagt ccgcatggtg actggggaca acatcaacac ggcccgggcc 2100
atcgcagcca aatgcggcat catccagccc ggggaggact tcctgtgcct agaagggaag 2160
gagttcaacc ggcggatccg caatgagaaa ggcgagatag aacaggagcg gctggacaag 2220
gtgtggccca agctgagggt gctggcccgg tcgtctccca ccgacaagca cacactggtc 2280
aaagggatta tcgacagcac cactggtgag cagcggcagg tggtggctgt gacaggggat 2340
ggcaccaacg atgggccggc cctcaagaag gcggacgtgg gcttcgccat gggcatcgca 2400
gggaccgacg tggccaagga ggcctccgac atcatcctga ccgatgacaa cttcaccagc 2460
atcgtcaagg cagtcatgtg gggccgtaac gtctatgaca gcatctccaa gttcctgcag 2520
tttcaactga cggtcaatgt ggtggctgtg atcgtggcct tcacaggtgc ctgcattact 2580
caggactctc ctctcaaagc cgtgcagatg ttgtgggtga acttgatcat ggacacattt 2640
gcctctctgg ccctggcgac ggagccaccc acagagtcgc tgctgctgcg gaagccgtac 2700
ggccgcgaca agcccctcat ctcccgcacc atgatgaaga acattctggg ccacgccgtg 2760
taccagctcg ccatcatctt caccctgctg tttgtcgggg agctcttctt cgacatcgac 2820
agcgggagga atgcgcccct gcactcgcca ccctcagagc actacaccat catcttcaac 2880
acgttcgtca tgatgcagct ctttaacgag atcaacgccc gcaagatcca cggcgagagg 2940
aacgtgttcg acggcatctt cagcaacccc atcttctgca ccatcgtttt gggcactttc 3000
gggattcaga ttgtcatcgt ccagtttggc gggaagccct tcagctgctc cccactatcc 3060
acagaacagt ggctctggtg cctgtttgtt ggtgttgggg agctggtctg gggacaggtc 3120
attgccacca tccccaccag ccagctcaag tgcctgaagg aagccgggca cgggcccggg 3180
aaggacgaga tgaccgacga ggagctggcc gaaggcgagg aagagatcga ccatgccgag 3240
cgggagctcc gcaggggcca gatcctctgg ttccggggcc tgaaccggat tcagacgcag 3300
atggaggtag tgagtacctt caagagaagc ggttcagttc agggtgctgt gcgccggcgg 3360
tcttcggtcc tcagccagct tcatgacgta accaatcttt ctacccctac tcacgcaatt 3420
ctctctgctg ccaatcctac cagtgctgct gggaatccgg gtggtgaaag cgttccgtag 3480
<210>123
<211>306
<212>DNA
<213>人
<400>123
atggagcgcc cggataaggc ggcgctgaac gcactgcagc ctcctgagtt cagaaatgaa 60
agctcattag catctacact gaagacgctc ctgttcttca cagctttaat gatcactgtt 120
cctattgggt tatatttcac aactaaatct tacatatttg aaggcgccct tgggatgtcc 180
aatagggaca gctattttta cgctgctatt gttgcagtgg tcgccgtcca tgtggtgctg 240
gccctctttg tgtatgtggc ctggaatgaa ggctcacgac agtggcgtga aggcaaacag 300
gattaa 306
<210>124
<211>2187
<212>DNA
<213>人
<400>124
atgctcccca ccctgcaaat ccagggccca gcagcctttg ctcctgggga tagaggccct 60
ggcaggcact gtcccttccc tgtgcccatc acccccactg gtgccctcct gccagtctct 120
gactcttgtg acagtctggt ggacctggtc tggccatctg ttacctatct tgccttgggg 180
acccagagca gagtctggcc acatcccttg ggggctcctg gtcaggctgg ggagtcacct 240
gaacaaagaa gacagtgtct agagctgtgg gacatggcca gctccctggg ggacaaggtc 300
cccagagcag catgtgggaa gagggggcag acagtgtggc agctgcatct cgcctgcctc 360
tgcctggccc agttccactc tccacctgct caacccccac ctctctccag aagaggaggg 420
ggacccgacc cggatccaat atcccgctcc ctgcctgggc ctcccacacc tgcactgccc 480
acacactcat acagctctca ctccccacgt gctccacgcc tcctgtcccc actgaggaga 540
gctcccagag gctcgcctgc tccccaccga cacgcgtccc tgcagacaaa cgaggcgccc 600
agggagcttc cccactgcac ttggccaggg ctgccggggc gcagccttgc ccctagcttc 660
ctctggcggg agccatggct cggaggacaa tggggacctc tgaacatacc tgcccgcaag 720
ggggaccgga ggcgctggga gtgggggtgt gagggaggtg gtgccacagc ctccgctgag 780
cagcctcccc agatcgtgta cttcactgct acattcccct acgtggtcct ggtcgtgctg 840
ctggtgcgtg gagtgctgct gcctggcgcc ctggatggca tcatttacta tctcaagcct 900
gactggtcaa agctggggtc ccctcaggtg tggatagatg cggggaccca gattttcttt 960
tcttacgcca ttggcctggg ggccctcaca gccctgggca gctacaaccg cttcaacaac 1020
aactgctaca aggacgccat catcctggct ctcatcaaca gtgggaccag cttctttgct 1080
ggcttcgtgg tcttctccat cctgggcttc atggctgcag agcagggcgt gcacatctcc 1140
aaggtggcag agtcagggcc gggcctggcc ttcatcgcct acccgcgggc tgtcacgctg 1200
atgccagtgg ccccactctg ggctgccctg ttcttcttca tgctgttgct gcttggtctc 1260
gacagccagg tttgcatggg gctctgggac agggagccag gaggggggcg gagggagggc 1320
tgcaggcaag gaaaggggtg gaggtgcggg gctcggcctg agctgccctg gccacagttt 1380
gtaggtgtgg agggcttcat caccggcctc ctcgacctcc tcccggcctc ctactacttc 1440
cgtttccaaa gggagatctc tgtggccctc tgttgtgccc tctgctttgt catcgatctc 1500
tccatggtga ctgatgtgag tggggtgggg ggtctgcctg tgacctctgg tggccgtctg 1560
ccatcctccc tgactgggct ctgtcccggc gggatgtacg tcttccagct gtttgactac 1620
tactcggcca gcggcaccac cctgctctgg caggcctttt gggagtgcgt ggtggtggcc 1680
tgggtgtacg gtaggtcatg gctgagggct gggctggggg atggtggcgg ggaaggcagg 1740
tctccagctt ggccctcccg cctcacctcg ccgcaggctg accgcttcat ggacgacatt 1800
gcctgtatga tcgggtaccg accttgcccc tggatgaaat ggtgctggtc cttcttcacc 1860
ccgctggtct gcatgggcat cttcatcttc aacgttgtgt actacgagcc gctggtctac 1920
aacaacacct acgtgtaccc gtggtggggt gaggccatgg gctgggcctt cgccctgtcc 1980
tccatgctgt gcgtgccgct gcacctcctg ggctgcctcc tcagggccaa gggcaccatg 2040
gctgagcgct ggcagcacct gacccagccc atctggggcc tccaccactt ggagtaccga 2100
gctcaggacg cagatgtcag gggcctgacc accctgaccc cagtgtccga gagcagcaag 2160
gtcgtcgtgg tggagagtgt catgtga 2187
<210>125
<211>3327
<212>DNA
<213>人
<400>125
atgcagatgg tcccatctct ccctccagcc tctgagtgtg ctggagaaga gaaacgagtt 60
ggcacacgca cagtgtttgt tggcaatcat ccagtttcgg aaacagaagc ttacattgca 120
caaagatttt gtgataatag aatagtctca tctaagtata cactttggaa ttttctccca 180
aagaatctgt ttgaacagtt tagaagaatt gcaaattttt attttctcat aatcttcctt 240
gtacaggtca cagtagacac accaactagc ccagttacca gtggacttcc acttttcttt 300
gttataactg ttacagccat caagcaggga tatgaggatt gtctgagaca cagagctgac 360
aatgaagtca acaaaagcac tgtttacatt attgaaaatg caaagcgagt gagaaaagaa 420
agtgaaaaaa tcaaggttgg tgatgtagta gaagtacagg cagatgaaac ctttccctgt 480
gatcttattc ttctatcatc ttgcaccact gatggaacct gttatgtcac tacagccagt 540
cttgatgggg aatccaattg caagacacat tatgcagtac gtgataccat tgcactgtgt 600
acagcagaat ccatcgatac cctccgagca gcaattgaat gtgaacagcc tcaacctgac 660
ctctacaaat ttgttgggcg aatcaatatc tacagtaata gtcttgaggc tgttgccagg 720
tctttgggac ctgaaaatct cttgctgaaa ggagctacgc taaaaaatac cgagaagata 780
tatggagttg ctgtttacac tggaatggaa accaaaatgg ctttgaacta ccaagggaaa 840
tctcagaaac gttctgctgt tgaaaaatct attaatgctt tcctgattgt atatttattt 900
atcttactga ccaaagctgc agtatgcact actctaaagt atgtttggca aagtacccca 960
tacaatgatg aaccttggta taaccaaaag actcagaaag agcgagagac cttgaaggtt 1020
ttaaaaatgt tcaccgactt cctatcattt atggttctat tcaactttat cattcctgtc 1080
tccatgtacg tcacagtaga aatgcagaaa ttcttgggct ccttcttcat ctcatgggat 1140
aaggactttt atgatgaaga aattaatgaa ggagccctgg ttaacacatc agaccttaat 1200
gaagaacttg gtcaggtgga ttatgtattt acagataaga ctggaacact cactgaaaac 1260
agcatggaat tcattgaatg ctgcatagat ggccacaaat ataaaggtgt aactcaagag 1320
gttgatggat tatctcaaac tgatggaact ttaacatatt ttgacaaagt agataagaat 1380
cgagaagagc tgtttctacg tgccttgtgt ttatgtcata ctgtagaaat caaaacaaac 1440
gatgctgttg atggagctac agaatcagct gaattaacct atatctcctc ttcaccagat 1500
gaaatagctt tggtgaaagg agctaaaagg tacgggttca catttttagg aaatcgaaat 1560
ggatatatga gagtagagaa ccaaagaaaa gaaatagaag aatatgaact tcttcacacc 1620
ttaaactttg atgctgtccg gcgacgtatg agtgtaattg tgaagactca agaaggagac 1680
atacttctct tttgtaaagg agcagactcg gcagtttttc ccagagtgca aaatcatgaa 1740
attgagttaa ctaaagtcca tgtggaacgt aatgcaatgg atgggtatcg gacactctgt 1800
gtagccttca aagaaattgc tccagatgat tatgaaagaa ttaacagaca gctcatagag 1860
gcaaaaatgg ccttacaaga cagagaagaa aaaatggaaa aagttttcga tgatattgag 1920
acaaacatga atttaattgg agccactgca gttgaagaca agctacaaga tcaagctgca 1980
gagaccattg aagctctgca tgcagcaggc ctgaaagtct gggtgctcac tggggacaag 2040
atggagacag ctaaatccac atgctatgcc tgccgccttt tccagaccaa cactgagctc 2100
ttagaactaa ccacaaaaac cattgaagaa agtgaaagga aagaagatcg attacatgaa 2160
ttattgatag aatatcgcaa gaaattgctg catgagtttc ctaaaagtac tagaagcttt 2220
aaaaaagcat ggacagaaca tcaggaatat ggattaatca tagatggctc cacattgtca 2280
ctcatactaa attctagtca agactctagt tcaaacaatt acaaaagcat tttcctacaa 2340
atatgtatga agtgtactgc agtgctctgc tgtcggatgg caccattaca gaaagcccag 2400
attgtcagaa tggtgaagaa tttaaaaggc agcccaataa ctctgtcgat aggtgatggt 2460
gccaatgatg ttagtatgat cttggaatcc catgtgggaa taggtattaa aggcaaagaa 2520
ggtcgccaag cagctaggaa tagcgattat tctgttccaa agtttaaaca cttaaagaaa 2580
ctgctgttgg ctcatggaca tctatattat gtgagaatag cacaccttgt acagtacttc 2640
ttctataaga acctttgttt cattttgcca cagtttttgt accagttctt ctgtggattc 2700
tcacaacagc cactgtatga tgctgcttac cttacaatgt acaatatctg cttcacatcc 2760
ttgcccatcc tggcctatag tctactggaa cagcacatca acattgacac tctgacctca 2820
gatccccgat tgtatatgaa aatttctggc aatgccatgc tacagttggg ccccttctta 2880
tattggacat ttctggctgc ctttgaaggg acagtgttct tctttgggac ttactttctt 2940
tttcagactg catccctaga agaaaatgga aaggtatacg gaaactggac ttttggaacc 3000
attgttttta cagtcttagt attcactgta accctgaagc ttgccttgga tacccgattc 3060
tggacgtgga taaatcactt tgtgatttgg ggttctttag ccttctatgt atttttctca 3120
ttcttctggg gaggaattat ttggcctttt ctcaagcaac agagaatgta ttttgtattt 3180
gcccaaatgc tgtcttctgt atccacatgg ttggctataa ttcttctaat atttatcagc 3240
ctgttccctg agattcttct gatagtatta aagaatgtaa gaagaagaag tgccagggtt 3300
catcacttaa tttcctcttc tgcataa 3327
<210>126
<211>3399
<212>DNA
<213>人
<400>126
atgcagatgg tcccatctct ccctccagcc tctgagtgtg ctggagaaga gaaacgagtt 60
ggcacacgca cagtgtttgt tggcaatcat ccagtttcgg aaacagaagc ttacattgca 120
caaagatttt gtgataatag aatagtctca tctaagtata cactttggaa ttttctccca 180
aagaatctgt ttgaacagtt tagaagaatt gcaaattttt attttctcat aatcttcctt 240
gtacaggtca cagtagacac accaactagc ccagttacca gtggacttcc acttttcttt 300
gttataactg ttacagccat caagcaggga tatgaggatt gtctgagaca cagagctgac 360
aatgaagtca acaaaagcac tgtttacatt attgaaaatg caaagcgagt gagaaaagaa 420
agtgaaaaaa tcaaggttgg tgatgtagta gaagtacagg cagatgaaac ctttccctgt 480
gatcttattc ttctatcatc ttgcaccact gatggaacct gttatgtcac tacagccagt 540
cttgatgggg aatccaattg caagacacat tatgcagtac gtgataccat tgcactgtgt 600
acagcagaat ccatcgatac cctccgagca gcaattgaat gtgaacagcc tcaacctgac 660
ctctacaaat ttgttgggcg aatcaatatc tacagtaata gtcttgaggc tgttgccagg 720
tctttgggac ctgaaaatct cttgctgaaa ggagctacgc taaaaaatac cgagaagata 780
tatggagttg ctgtttacac tggaatggaa accaaaatgg ctttgaacta ccaagggaaa 840
tctcagaaac gttctgctgt tgaaaaatct attaatgctt tcctgattgt atatttattt 900
atcttactga ccaaagctgc agtatgcact actctaaagt atgtttggca aagtacccca 960
tacaatgatg aaccttggta taaccaaaag actcagaaag agcgagagac cttgaaggtt 1020
ttaaaaatgt tcaccgactt cctatcattt atggttctat tcaactttat cattcctgtc 1080
tccatgtacg tcacagtaga aatgcagaaa ttcttgggct ccttcttcat ctcatgggat 1140
aaggactttt atgatgaaga aattaatgaa ggagccctgg ttaacacatc agaccttaat 1200
gaagaacttg gtcaggtgga ttatgtattt acagataaga ctggaacact cactgaaaac 1260
agcatggaat tcattgaatg ctgcatagat ggccacaaat ataaaggtgt aactcaagag 1320
gttgatggat tatctcaaac tgatggaact ttaacatatt ttgacaaagt agataagaat 1380
cgagaagagc tgtttctacg tgccttgtgt ttatgtcata ctgtagaaat caaaacaaac 1440
gatgctgttg atggagctac agaatcagct gaattaacct atatctcctc ttcaccagat 1500
gaaatagctt tggtgaaagg agctaaaagg tacgggttca catttttagg aaatcgaaat 1560
ggatatatga gagtagagaa ccaaagaaaa gaaatagaag aatatgaact tcttcacacc 1620
ttaaactttg atgctgtccg gcgacgtatg agtgtaattg tgaagactca agaaggagac 1680
atacttctct tttgtaaagg agcagactcg gcagtttttc ccagagtgca aaatcatgaa 1740
attgagttaa ctaaagtcca tgtggaacgt aatgcaatgg atgggtatcg gacactctgt 1800
gtagccttca aagaaattgc tccagatgat tatgaaagaa ttaacagaca gctcatagag 1860
gcaaaaatgg ccttacaaga cagagaagaa aaaatggaaa aagttttcga tgatattgag 1920
acaaacatga atttaattgg agccactgca gttgaagaca agctacaaga tcaagctgca 1980
gagaccattg aagctctgca tgcagcaggc ctgaaagtct gggtgctcac tggggacaag 2040
atggagacag ctaaatccac atgctatgcc tgccgccttt tccagaccaa cactgagctc 2100
ttagaactaa ccacaaaaac cattgaagaa agtgaaagga aagaagatcg attacatgaa 2160
ttattgatag aatatcgcaa gaaattgctg catgagtttc ctaaaagtac tagaagcttt 2220
aaaaaagcat ggacagaaca tcaggaatat ggattaatca tagatggctc cacattgtca 2280
ctcatactaa attctagtca agactctagt tcaaacaatt acaaaagcat tttcctacaa 2340
atatgtatga agtgtactgc agtgctctgc tgtcggatgg caccattaca gaaagcccag 2400
attgtcagaa tggtgaagaa tttaaaaggc agcccaataa ctctgtcgat aggtgatggt 2460
gccaatgatg ttagtatgat cttggaatcc catgtgggaa taggtattaa aggcaaagaa 2520
ggtcgccaag cagctaggaa tagcgattat tctgttccaa agtttaaaca cttaaagaaa 2580
ctgctgttgg ctcatggaca tctatattat gtgagaatag cacaccttgt acagtacttc 2640
ttctataaga acctttgttt cattttgcca cagtttttgt accagttctt ctgtggattc 2700
tcacaacagc cactgtatga tgctgcttac cttacaatgt acaatatctg cttcacatcc 2760
ttgcccatcc tggcctatag tctactggaa cagcacatca acattgacac tctgacctca 2820
gatccccgat tgtatatgaa aatttctggc aatgccatgc tacagttggg ccccttctta 2880
tattggacat ttctggctgc ctttgaaggg acagtgttct tctttgggac ttactttctt 2940
tttcagactg catccctaga agaaaatgga aaggtatacg gaaactggac ttttggaacc 3000
attgttttta cagtcttagt attcactgta accctgaagc ttgccttgga tacccgattc 3060
tggacgtgga taaatcactt tgtgatttgg ggttctttag ccttctatgt atttttctca 3120
ttcttctggg gaggaattat ttggcctttt ctcaagcaac agagaatgta ttttgtattt 3180
gcccaaatgc tgtcttctgt atccacatgg ttggctataa ttcttctaat atttatcagc 3240
ctgttccctg agattcttct gatagtatta aagaatgtaa gaagaagaag tgccaggaga 3300
aatctgagct gtagaagggc atctgactca ttatccgcca gaccttcagt cagacctctt 3360
cttttacgaa cattctcaga cgaatctaat gtattgtaa 3399
<210>127
<211>3621
<212>DNA
<213>人
<400>127
atgggcgaca tggccaatag ttccatcgag ttccacccca agccccagca gcagcgggat 60
gtcccccagg ctggaggctt tgggtgcacg ctggcggagc tgcgcaccct catggagctg 120
cgaggggccg aggcgctgca gaagatcgag gaggcctacg gggatgtcag cgggctctgc 180
cggaggctga agacctcacc cacagagggc ctggcggaca acaccaatga cctggagaag 240
cgcaggcaga tctacgggca gaacttcatc cccccaaagc aacccaagac cttcctgcag 300
ctggtgtggg aggccctgca ggacgtgacc ctcatcatcc tggaggtggc tgccatcgtc 360
tctctgggcc tctcgttcta tgcgccgcca ggagaggaga gtgaagcctg tgggaatgtg 420
tcgggaggcg cagaagatga gggcgaggcc gaagctggct ggatcgaggg ggctgccatc 480
ctgctgtccg tcatctgtgt ggtgctggtc acggccttca atgactggag caaggagaag 540
cagttccgag gcctgcagag ccgaattgag caggagcaga agttcacggt catccggaac 600
gggcagctcc tccaggtccc cgtggctgcg ctggtggtgg gggacattgc ccaggtcaag 660
tacggcgacc tgctgccagc cgacggcgtg ctcatccagg ccaatgacct caagatcgac 720
gagagctccc tgacgggcga gtctgaccac gtgcgcaagt cagctgacaa agatcccatg 780
ctgctctcag gcactcatgt catggaaggt tctggaagaa tggtggtgac cgccgttggc 840
gtgaattccc agacaggcat catcttcacg ctgcttggag ctggcggaga ggaggaagag 900
aagaaagata agaaagctaa gaagcaggat ggtgcagtgg ccatggagat gcagcccctg 960
aagagcgcgg agggtgggga gatggaggag cgggagaaga agaaagccaa cgcacccaaa 1020
aaggagaagt ctgtccttca ggggaagctc acaaagctag ccgtgcagat cgggaaagca 1080
gggctggtga tgtctgccat caccgtcatc atcctggtcc tctactttgt gattgagacg 1140
tttgtcgtgg aaggccggac atggctggca gagtgcacgc cggtctatgt acaatacttc 1200
gtgaagttct tcatcattgg tgtcactgtg ctggtcgtgg ctgtcccaga gggcctgcct 1260
cttgctgtca ccatctcctt agcttactct gtcaagaaaa tgatgaaaga caacaacctg 1320
gtgcgccacc tggatgcctg cgagaccatg ggcaacgcca cagccatctg ctccgacaag 1380
acgggcacgc tcaccaccaa ccgtatgacc gtggtccagt cctacctagg agacacccac 1440
tacaaagaga ttccggcccc cagcgccctg acccctaaga tcctcgacct cctggtccat 1500
gccatctcca tcaacagtgc ctataccacc aaaatactac ctcctgagaa ggaaggcgcc 1560
ctcccacgcc aggtgggcaa taagacggag tgcgccctgc tgggcttcgt cttggacctg 1620
aagcgggact tccagcccgt gcgcgagcag atcccggaag acaagcttta caaagtgtac 1680
accttcaact cggtccgcaa gtccatgagc acagtcatcc gcatgcccga cggtggcttc 1740
cgcctcttca gcaagggggc ctcagagatc ctcttgaaaa agtgcaccaa catcttgaac 1800
agcaatggcg aactccgggg ctttcggcct cgggaccggg acgacatggt gaggaagatc 1860
atcgagccga tggcttgcga tggcctccgc accatctgca tcgcctaccg ggacttctct 1920
gcaggccagg agcccgactg ggacaacgag aatgaggtcg tgggtgacct cacctgcata 1980
gctgtcgtgg gcattgagga ccctgtgcgg cccgaggtcc ctgaagctat ccgaaaatgc 2040
cagcgtgctg gcatcacagt ccgcatggtg actggggaca acatcaacac ggcccgggcc 2100
atcgcagcca aatgcggcat catccagccc ggggaggact tcctgtgcct agaagggaag 2160
gagttcaacc ggcggatccg caatgagaaa ggcgagatag aacaggagcg gctggacaag 2220
gtgtggccca agctgagggt gctggcccgg tcgtctccca ccgacaagca cacactggtc 2280
aaagggatta tcgacagcac cactggtgag cagcggcagg tggtggctgt gacaggggat 2340
ggcaccaacg atgggccggc cctcaagaag gcggacgtgg gcttcgccat gggcatcgca 2400
gggaccgacg tggccaagga ggcctccgac atcatcctga ccgatgacaa cttcaccagc 2460
atcgtcaagg cagtcatgtg gggccgtaac gtctatgaca gcatctccaa gttcctgcag 2520
tttcaactga cggtcaatgt ggtggctgtg atcgtggcct tcacaggtgc ctgcattact 2580
caggactctc ctctcaaagc cgtgcagatg ttgtgggtga acttgatcat ggacacattt 2640
gcctctctgg ccctggcgac ggagccaccc acagagtcgc tgctgctgcg gaagccgtac 2700
ggccgcgaca agcccctcat ctcccgcacc atgatgaaga acattctggg ccacgccgtg 2760
taccagctcg ccatcatctt caccctgctg tttgtcgggg agctcttctt cgacatcgac 2820
agcgggagga atgcgcccct gcactcgcca ccctcagagc actacaccat catcttcaac 2880
acgttcgtca tgatgcagct ctttaacgag atcaacgccc gcaagatcca cggcgagagg 2940
aacgtgttcg acggcatctt cagcaacccc atcttctgca ccatcgtttt gggcactttc 3000
gggattcaga ttgtcatcgt ccagtttggc gggaagccct tcagctgctc cccactatcc 3060
acagaacagt ggctctggtg cctgtttgtt ggtgttgggg agctggtctg gggacaggtc 3120
attgccacca tccccaccag ccagctcaag tgcctgaagg aagccgggca cgggcccggg 3180
aaggacgaga tgaccgacga ggagctggcc gaaggcgagg aagagatcga ccatgccgag 3240
cgggagctcc gcaggggcca gatcctctgg ttccggggcc tgaaccggat tcagacgcag 3300
atccgggtgg tgaaagcgtt ccgtagctcg ctctatgaag gcctggagaa accagaatcc 3360
aagacctcca ttcacaactt catggccacg cccgagtttc tgatcaatga ctacacccac 3420
aacatcccgc tcattgacga cacggacgtg gacgagaacg aggagcgcct ccgggccccc 3480
ccgcccccgt cccccaacca gaacaacaac gccatagaca gcggcatcta cctgaccacg 3540
catgtcacca agtcagctac ctcttcagtg ttttcctcca gtcccgggag cccgctccac 3600
agcgtggaga cgtccctcta a 3621
<210>128
<211>3762
<212>DNA
<213>人
<400>128
atggtcgtgg cgctgcggta cgtgtggcct ctcctcctct gcagcccctg cctgct tatc 60
cagatccccg aggaatatga aggacaccat gtgatggagc cacctgtcat cacggaacag 120
tctccacggc gcctggttgt cttccccaca gatgacatca gcctcaagtg tgaggccagt 180
ggcaagcccg aagtgcagtt ccgctggacg agggatggtg tccacttcaa acccaaggaa 240
gagctgggtg tgaccgtgta ccagtcgccc cactctggct ccttcaccat cacgggcaac 300
aacagcaact ttgctcagag gttccagggc atctaccgct gctttgccag caataagctg 360
ggcaccgcca tgtcccatga gatccggctc atggccgagg gtgcccccaa gtggccaaag 420
gagacagtga agcccgtgga ggtggaggaa ggggagtcag tggttctgcc ttgcaaccct 480
cccccaagtg cagagcctct ccggatctac tggatgaaca gcaagatctt gcacatcaag 540
caggacgagc gggtgacgat gggccagaac ggcaacctct actttgccaa tgtgctcacc 600
tccgacaacc actcagacta catctgccac gcccacttcc caggcaccag gaccatcatt 660
cagaaggaac ccattgacct ccgggtcaag gccaccaaca gcatgattga caggaagccg 720
cgcctgctct tccccaccaa ctccagcagc cacctggtgg ccttgcaggg gcagccattg 780
gtcctggagt gcatcgccga gggctttccc acgcccacca tcaaatggct gcgccccagt 840
ggccccatgc cagccgaccg tgtcacctac cagaaccaca acaagaccct gcagctgctg 900
aaagtgggcg aggaggatga tggcgagtac cgctgcctgg ccgagaactc actgggcagt 960
gcccggcatg cgtactatgt caccgtggag gctgccccgt actggctgca caagccccag 1020
agccatctat atgggccagg agagactgcc cgcctggact gccaagtcca gggcaggccc 1080
caaccagagg tcacctggag aatcaacggg atccctgtgg aggagctggc caaagaccag 1140
aagtaccgga ttcagcgtgg cgccctgatc ctgagcaacg tgcagcccag tgacacaatg 1200
gtgacccaat gtgaggcccg caaccggcac gggctcttgc tggccaatgc ctacatctac 1260
gttgtccagc tgccagccaa gatcctgact gcggacaatc agacgtacat ggctgtccag 1320
ggcagcactg cctaccttct gtgcaaggcc ttcggagcgc ctgtgcccag tgttcagtgg 1380
ctggacgagg atgggacaac agtgcttcag gacgaacgct tcttccccta tgccaatggg 1440
accctgggca ttcgagacct ccaggccaat gacaccggac gctacttctg cctggctgcc 1500
aatgaccaaa acaatgttac catcatggct aacctgaagg ttaaagatgc aactcagatc 1560
actcaggggc cccgcagcac aatcgagaag aaaggttcca gggtgacctt cacgtgccag 1620
gcctcctttg acccctcctt gcagcccagc atcacctggc gtggggacgg tcgagacctc 1680
caggagcttg gggacagtga caagtacttc atagaggatg ggcgcctggt catccacagc 1740
ctggactaca gcgaccaggg caactacagc tgcgtggcca gtaccgaact ggatgtggtg 1800
gagagtaggg cacagctctt ggtggtgggg agccctgggc cggtgccacg gctggtgctg 1860
tccgacctgc acctgctgac gcagagccag gtgcgcgtgt cctggagtcc tgcagaagac 1920
cacaatgccc ccattgagaa atatgacatt gaatttgagg acaaggaaat ggcgcctgaa 1980
aaatggtaca gtctgggcaa ggttccaggg aaccagacct ctaccaccct caagctgtcg 2040
ccctatgtcc actacacctt tagggttact gccataaaca aatatggccc cggggagccc 2100
agcccggtct ctgagactgt ggtcacacct gaggcagccc cagagaagaa ccctgtggat 2160
gtgaaggggg aaggaaatga gaccaccaat atggtcatca cgtggaagcc gctccggtgg 2220
atggactgga acgcccccca ggttcagtac cgcgtgcagt ggcgccctca ggggacacga 2280
gggccctggc aggagcagat tgtcagcgac cccttcctgg tggtgtccaa cacgtccacc 2340
ttcgtgccct atgagatcaa agtccaggcc gtcaacagcc agggcaaggg accagagccc 2400
caggtcacta tcggctactc tggagaggac tacccccagg caatccctga gctggaaggc 2460
attgaaatcc tcaactcaag tgccgtgctg gtcaagtggc ggccggtgga cctggcccag 2520
gtcaagggcc acctccgcgg atacaatgtg acgtactgga gggagggcag tcagaggaag 2580
cacagcaaga gacatatcca caaagaccat gtggtggtgc ccgccaacac caccagtgtc 2640
atcctcagtg gcttgcggcc ctatagctcc taccacctgg aggtgcaggc ctttaacggg 2700
cgaggatcgg ggcccgccag cgagttcacc ttcagcaccc cagagggagt gcctggccac 2760
cccgaggcgt tgcacctgga gtgccagtcg aacaccagcc tgctgctgcg ctggcagccc 2820
ccactcagcc acaacggcgt gctcaccggc tacgtgctct cctaccaccc cctggatgag 2880
gggggcaagg ggcaactgtc cttcaacctt cgggaccccg aacttcggac acacaacctg 2940
accgatctca gcccccacct gcggtaccgc ttccagcttc aggccaccac caaagagggc 3000
cctggtgaag ccatcgtacg ggaaggaggc actatggcct tgtctgggat ctcagatttt 3060
ggcaacatct cagccacagc gggtgaaaac tacagtgtcg tctcctgggt ccccaaggag 3120
ggccagtgca acttcaggtt ccatatcttg ttcaaagcct tgggagaaga gaagggtggg 3180
gcttcccttt cgccacagta tgtcagctac aaccagagct cctacacgca gtgggacctg 3240
cagcctgaca ctgactacga gatccacttg tttaaggaga ggatgttccg gcaccaaatg 3300
gctgtgaaga ccaatggcac aggccgcgtg aggctccctc ctgctggctt cgccactgag 3360
ggctggttca tcggctttgt gagtgccatc atcctcctgc tcctcgtcct gctcatcctc 3420
tgcttcatca agcgcagcaa gggcggcaaa tactcagtga aggataagga ggacacccag 3480
gtggactctg aggcccgacc gatgaaagat gagaccttcg gcgagtacag tgacaacgag 3540
gagaaggcct ttggcagcag ccagccatcg ctcaacgggg acatcaagcc cctgggcagt 3600
gacgacagcc tggccgatta tgggggcagc gtggatgttc agttcaacga ggatggttcg 3660
ttcattggcc agtacagtgg caagaaggag aaggaggcgg cagggggcaa tgacagctca 3720
ggggccactt cccccatcaa ccctgccgtg gccctagaat ag 3762
<210>129
<211>3774
<212>DNA
<213>人
<400>129
atggtcgtgg cgctgcggta cgtgtggcct ctcctcctct gcagcccctg cctgcttatc 60
cagatccccg aggaatatga aggacaccat gtgatggagc cacctgtcat cacggaacag 120
tctccacggc gcctggttgt cttccccaca gatgacatca gcctcaagtg tgaggccagt 180
ggcaagcccg aagtgcagtt ccgctggacg agggatggtg tccacttcaa acccaaggaa 240
gagctgggtg tgaccgtgta ccagtcgccc cactctggct ccttcaccat cacgggcaac 300
aacagcaact ttgctcagag gttccagggc atctaccgct gctttgccag caataagctg 360
ggcaccgcca tgtcccatga gatccggctc atggccgagg gtgcccccaa gtggccaaag 420
gagacagtga agcccgtgga ggtggaggaa ggggagtcag tggttctgcc ttgcaaccct 480
cccccaagtg cagagcctct ccggatctac tggatgaaca gcaagatctt gcacatcaag 540
caggacgagc gggtgacgat gggccagaac ggcaacctct actttgccaa tgtgctcacc 600
tccgacaacc actcagacta catctgccac gcccacttcc caggcaccag gaccatcatt 660
cagaaggaac ccattgacct ccgggtcaag gccaccaaca gcatgattga caggaagccg 720
cgcctgctct tccccaccaa ctccagcagc cacctggtgg ccttgcaggg gcagccattg 780
gtcctggagt gcatcgccga gggctttccc acgcccacca tcaaatggct gcgccccagt 840
ggccccatgc cagccgaccg tgtcacctac cagaaccaca acaagaccct gcagctgctg 900
aaagtgggcg aggaggatga tggcgagtac cgctgcctgg ccgagaactc actgggcagt 960
gcccggcatg cgtactatgt caccgtggag gctgccccgt actggctgca caagccccag 1020
agccatctat atgggccagg agagactgcc cgcctggact gccaagtcca gggcaggccc 1080
caaccagagg tcacctggag aatcaacggg atccctgtgg aggagctggc caaagaccag 1140
aagtaccgga ttcagcgtgg cgccctgatc ctgagcaacg tgcagcccag tgacacaatg 1200
gtgacccaat gtgaggcccg caaccggcac gggctcttgc tggccaatgc ctacatctac 1260
gttgtccagc tgccagccaa gatcctgact gcggacaatc agacgtacat ggctgtccag 1320
ggcagcactg cctaccttct gtgcaaggcc ttcggagcgc ctgtgcccag tgttcagtgg 1380
ctggacgagg atgggacaac agtgcttcag gacgaacgct tcttccccta tgccaatggg 1440
accctgggca ttcgagacct ccaggccaat gacaccggac gctacttctg cctggctgcc 1500
aatgaccaaa acaatgttac catcatggct aacctgaagg ttaaagatgc aactcagatc 1560
actcaggggc cccgcagcac aatcgagaag aaaggttcca gggtgacctt cacgtgccag 1620
gcctcctttg acccctcctt gcagcccagc atcacctggc gtggggacgg tcgagacctc 1680
caggagcttg gggacagtga caagtacttc atagaggatg ggcgcctggt catccacagc 1740
ctggactaca gcgaccaggg caactacagc tgcgtggcca gtaccgaact ggatgtggtg 1800
gagagtaggg cacagctctt ggtggtgggg agccctgggc cggtgccacg gctggtgctg 1860
tccgacctgc acctgctgac gcagagccag gtgcgcgtgt cctggagtcc tgcagaagac 1920
cacaatgccc ccattgagaa atatgacatt gaatttgagg acaaggaaat ggcgcctgaa 1980
aaatggtaca gtctgggcaa ggttccaggg aaccagacct ctaccaccct caagctgtcg 2040
ccctatgtcc actacacctt tagggttact gccataaaca aatatggccc cggggagccc 2100
agcccggtct ctgagactgt ggtcacacct gaggcagccc cagagaagaa ccctgtggat 2160
gtgaaggggg aaggaaatga gaccaccaat atggtcatca cgtggaagcc gctccggtgg 2220
atggactgga acgcccccca ggttcagtac cgcgtgcagt ggcgccctca ggggacacga 2280
gggccctggc aggagcagat tgtcagcgac cccttcctgg tggtgtccaa cacgtccacc 2340
ttcgtgccct atgagatcaa agtccaggcc gtcaacagcc agggcaaggg accagagccc 2400
caggtcacta tcggctactc tggagaggac tacccccagg caatccctga gctggaaggc 2460
attgaaatcc tcaactcaag tgccgtgctg gtcaagtggc ggccggtgga cctggcccag 2520
gtcaagggcc acctccgcgg atacaatgtg acgtactgga gggagggcag tcagaggaag 2580
cacagcaaga gacatatcca caaagaccat gtggtggtgc ccgccaacac caccagtgtc 2640
atcctcagtg gcttgcggcc ctatagctcc taccacctgg aggtgcaggc ctttaacggg 2700
cgaggatcgg ggcccgccag cgagttcacc ttcagcaccc cagagggagt gcctggccac 2760
cccgaggcgt tgcacctgga gtgccagtcg aacaccagcc tgctgctgcg ctggcagccc 2820
ccactcagcc acaacggcgt gctcaccggc tacgtgctct cctaccaccc cctggatgag 2880
gggggcaagg ggcaactgtc cttcaacctt cgggaccccg aacttcggac acacaacctg 2940
accgatctca gcccccacct gcggtaccgc ttccagcttc aggccaccac caaagagggc 3000
cctggtgaag ccatcgtacg ggaaggaggc actatggcct tgtctgggat ctcagatttt 3060
ggcaacatct cagccacagc gggtgaaaac tacagtgtcg tctcctgggt ccccaaggag 3120
ggccagtgca acttcaggtt ccatatcttg ttcaaagcct tgggagaaga gaagggtggg 3180
gcttcccttt cgccacagta tgtcagctac aaccagagct cctacacgca gtgggacctg 3240
cagcctgaca ctgactacga gatccacttg tttaaggaga ggatgttccg gcaccaaatg 3300
gctgtgaaga ccaatggcac aggccgcgtg aggctccctc ctgctggctt cgccactgag 3360
ggctggttca tcggctttgt gagtgccatc atcctcctgc tcctcgtcct gctcatcctc 3420
tgcttcatca agcgcagcaa gggcggcaaa tactcagtga aggataagga ggacacccag 3480
gtggactctg aggcccgacc gatgaaagat gagaccttcg gcgagtacag gtccctggag 3540
agtgacaacg aggagaaggc ctttggcagc agccagccat cgctcaacgg ggacatcaag 3600
cccctgggca gtgacgacag cctggccgat tatgggggca gcgtggatgt tcagttcaac 3660
gaggatggtt cgttcattgg ccagtacagt ggcaagaagg agaaggaggc ggcagggggc 3720
aatgacagct caggggccac ttcccccatc aaccctgccg tggccctaga atag 3774
<210>130
<211>3762
<212>DNA
<213>人
<400>130
atggtcgtgg cgctgcggta cgtgtggcct ctcctcctct gcagcccctg cctgcttatc 60
cagatccccg aggaatatga aggacaccat gtgatggagc cacctgtcat cacggaacag 120
tctccacggc gcctggttgt cttccccaca gatgacatca gcctcaagtg tgaggccagt 180
ggcaagcccg aagtgcagtt ccgctggacg agggatggtg tccacttcaa acccaaggaa 240
gagctgggtg tgaccgtgta ccagtcgccc cactctggct ccttcaccat cacgggcaac 300
aacagcaact ttgctcagag gttccagggc atctaccgct gctttgccag caataagctg 360
ggcaccgcca tgtcccatga gatccggctc atggccgagg gtgcccccaa gtggccaaag 420
gagacagtga agcccgtgga ggtggaggaa ggggagtcag tggttctgcc ttgcaaccct 480
cccccaagtg cagagcctct ccggatctac tggatgaaca gcaagatctt gcacatcaag 540
caggacgagc gggtgacgat gggccagaac ggcaacctct actttgccaa tgtgctcacc 600
tccgacaacc actcagacta catctgccac gcccacttcc caggcaccag gaccatcatt 660
cagaaggaac ccattgacct ccgggtcaag gccaccaaca gcatgattga caggaagccg 720
cgcctgctct tccccaccaa ctccagcagc cacctggtgg ccttgcaggg gcagccattg 780
gtcctggagt gcatcgccga gggctttccc acgcccacca tcaaatggct gcgccccagt 840
ggccccatgc cagccgaccg tgtcacctac cagaaccaca acaagaccct gcagctgctg 900
aaagtgggcg aggaggatga tggcgagtac cgctgcctgg ccgagaactc actgggcagt 960
gcccggcatg cgtactatgt caccgtggag gctgccccgt actggctgca caagccccag 1020
agccatctat atgggccagg agagactgcc cgcctggact gccaagtcca gggcaggccc 1080
caaccagagg tcacctggag aatcaacggg atccctgtgg aggagctggc caaagaccag 1140
aagtaccgga ttcagcgtgg cgccctgatc ctgagcaacg tgcagcccag tgacacaatg 1200
gtgacccaat gtgaggcccg caaccggcac gggctcttgc tggccaatgc ctacatctac 1260
gttgtccagc tgccagccaa gatcctgact gcggacaatc agacgtacat ggctgtccag 1320
ggcagcactg cctaccttct gtgcaaggcc ttcggagcgc ctgtgcccag tgttcagtgg 1380
ctggacgagg atgggacaac agtgcttcag gacgaacgct tcttccccta tgccaatggg 1440
accctgggca ttcgagacct ccaggccaat gacaccggac gctacttctg cctggctgcc 1500
aatgaccaaa acaatgttac catcatggct aacctgaagg ttaaagatgc aactcagatc 1560
actcaggggc cccgcagcac aatcgagaag aaaggttcca gggtgacctt cacgtgccag 1620
gcctcctttg acccctcctt gcagcccagc atcacctggc gtggggacgg tcgagacctc 1680
caggagcttg gggacagtga caagtacttc atagaggatg ggcgcctggt catccacagc 1740
ctggactaca gcgaccaggg caactacagc tgcgtggcca gtaccgaact ggatgtggtg 1800
gagagtaggg cacagctctt ggtggtgggt aaccctgggc cggtgccacg gctggtgctg 1860
tccgacctgc acctgctgac gcagagccag gtgcgcgtgt cctggagtcc tgcagaagac 1920
cacaatgccc ccattgagaa atatgacatt gaatttgagg acaaggaaat ggcgcctgaa 1980
aaatggtaca gtctgggcaa ggttccaggg aaccagacct ctaccaccct caagctgtcg 2040
ccctatgtcc actacacctt tagggttact gccataaaca aatatggccc cggggagccc 2100
agcccggtct ctgagactgt ggtcacacct gaggcagccc cagagaagaa ccctgtggat 2160
gtgaaggggg aaggaaatga gaccaccaat atggtcatca cgtggaagcc gctccggtgg 2220
atggactgga acgcccccca ggttcagtac cgcgtgcagt ggcgccctca ggggacacga 2280
gggccctggc aggagcagat tgtcagcgac cccttcctgg tggtgtccaa cacgtccacc 2340
ttcgtgccct atgagatcaa agtccaggcc gtcaacagcc agggcaaggg accagagccc 2400
caggtcacta tcggctactc tggagaggac tacccccagg caatccctga gctggaaggc 2460
attgaaatcc tcaactcaag tgccgtgctg gtcaagtggc ggccggtgga cctggcccag 2520
gtcaagggcc acctccgcgg atacaatgtg acgtactgga gggagggcag tcagaggaag 2580
cacagcaaga gacatatcca caaagaccat gtggtggtgc ccgccaacac caccagtgtc 2640
atcctcagtg gcttgcggcc ctatagctcc taccacctgg aggtgcaggc ctttaacggg 2700
cgaggatcgg ggcccgccag cgagttcacc ttcagcaccc cagagggagt gcctggccac 2760
cccgaggcgt tgcacctgga gtgccagtcg aacaccagcc tgctgctgcg ctggcagccc 2820
ccactcagcc acaacggcgt gctcaccggc tacgtgctct cctaccaccc cctggatgag 2880
gggggcaagg ggcaactgtc cttcaacctt cgggaccccg aacttcggac acacaacctg 2940
accgatctca gcccccacct gcggtaccgc ttccagcttc aggccaccac caaagagggc 3000
cctggtgaag ccatcgtacg ggaaggaggc actatggcct tgtctgggat ctcagatttt 3060
ggcaacatct cagccacagc gggtgaaaac tacagtgtcg tctcctgggt ccccaaggag 3120
ggccagtgca acttcaggtt ccatatcttg ttcaaagcct tgggagaaga gaagggtggg 3180
gcttcccttt cgccacagta tgtcagctac aaccagagct cctacacgca gtgggacctg 3240
cagcctgaca ctgactacga gatccacttg tttaaggaga ggatgttccg gcaccaaatg 3300
gctgtgaaga ccaatggcac aggccgcgtg aggctccctc ctgctggctt cgccactgag 3360
ggctggttca tcggctttgt gagtgccatc atcctcctgc tcctcgtcct gctcatcctc 3420
tgcttcatca agcgcagcaa gggcggcaaa tactcagtga aggataagga ggacacccag 3480
gtggactctg aggcccgacc gatgaaagat gagaccttcg gcgagtacag tgacaacgag 3540
gagaaggcct ttggcagcag ccagccatcg ctcaacgggg acatcaagcc cctgggcagt 3600
gacgacagcc tggccgatta tgggggcagc gtggatgttc agttcaacga ggatggttcg 3660
ttcattggcc agtacagtgg caagaaggag aaggaggcgg cagggggcaa tgacagctca 3720
ggggccactt cccccatcaa ccctgccgtg gccctagaat ag 3762
<210>131
<211>3663
<212>DNA
<213>人
<400>131
atgggcgaca tggccaatag ttccatcgag ttccacccca agccccagca gcagcgggat 60
gtcccccagg ctggaggctt tgggtgcacg ctggcggagc tgcgcaccct catggagctg 120
cgaggggccg aggcgctgca gaagatcgag gaggcctacg gggatgtcag cgggctctgc 180
cggaggctga agacctcacc cacagagggc ctggcggaca acaccaatga cctggagaag 240
cgcaggcaga tctacgggca gaacttcatc cccccaaagc aacccaagac cttcctgcag 300
ctggtgtggg aggccctgca ggacgtgacc ctcatcatcc tggaggtggc tgccatcgtc 360
tctctgggcc tctcgttcta tgcgccgcca ggagaggaga gtgaagcctg tgggaatgtg 420
tcgggaggcg cagaagatga gggcgaggcc gaagctggct ggatcgaggg ggctgccatc 480
ctgctgtccg tcatctgtgt ggtgctggtc acggccttca atgactggag caaggagaag 540
cagttccgag gcctgcagag ccgaattgag caggagcaga agttcacggt catccggaac 600
gggcagctcc tccaggtccc cgtggctgcg ctggtggtgg gggacattgc ccaggtcaag 660
tacggcgacc tgctgccagc cgacggcgtg ctcatccagg ccaatgacct caagatcgac 720
gagagctccc tgacgggcga gtctgaccac gtgcgcaagt cagctgacaa agatcccatg 780
ctgctctcag gcactcatgt catggaaggt tctggaagaa tggtggtgac cgccgttggc 840
gtgaattccc agacaggcat catcttcacg ctgcttggag ctggcggaga ggaggaagag 900
aagaaagata agaaaggcaa gcagcaggat ggggccatgg agagtagcca gaccaaagct 960
aagaagcagg atggtgcagt ggccatggag atgcagcccc tgaagagcgc ggagggtggg 1020
gagatggagg agcgggagaa gaagaaagcc aacgcaccca aaaaggagaa gtctgtcctt 1080
caggggaagc tcacaaagct agccgtgcag atcgggaaag cagggctggt gatgtctgcc 1140
atcaccgtca tcatcctggt cctctacttt gtgattgaga cgtttgtcgt ggaaggccgg 1200
acatggctgg cagagtgcac gccggtctat gtacaatact tcgtgaagtt cttcatcatt 1260
ggtgtcactg tgctggtcgt ggctgtccca gagggcctgc ctcttgctgt caccatctcc 1320
ttagcttact ctgtcaagaa aatgatgaaa gacaacaacc tggtgcgcca cctggatgcc 1380
tgcgagacca tgggcaacgc cacagccatc tgctccgaca agacgggcac gctcaccacc 1440
aaccgtatga ccgtggtcca gtcctaccta ggagacaccc actacaaaga gattccggcc 1500
cccagcgccc tgacccctaa gatcctcgac ctcctggtcc atgccatctc catcaacagt 1560
gcctatacca ccaaaatact acctcctgag aaggaaggcg ccctcccacg ccaggtgggc 1620
aataagacgg agtgcgccct gctgggcttc gtcttggacc tgaagcggga cttccagccc 1680
gtgcgcgagc agatcccgga agacaagctt tacaaagtgt acaccttcaa ctcggtccgc 1740
aagtccatga gcacagtcat ccgcatgccc gacggtggct tccgcctctt cagcaagggg 1800
gcctcagaga tcctcttgaa aaagtgcacc aacatcttga acagcaatgg cgaactccgg 1860
ggctttcggc ctcgggaccg ggacgacatg gtgaggaaga tcatcgagcc gatggcttgc 1920
gatggcctcc gcaccatctg catcgcctac cgggacttct ctgcaggcca ggagcccgac 1980
tgggacaacg agaatgaggt cgtgggtgac ctcacctgca tagctgtcgt gggcattgag 2040
gaccctgtgc ggcccgaggt ccctgaagct atccgaaaat gccagcgtgc tggcatcaca 2100
gtccgcatgg tgactgggga caacatcaac acggcccggg ccatcgcagc caaatgcggc 2160
atcatccagc ccggggagga cttcctgtgc ctagaaggga aggagttcaa ccggcggatc 2220
cgcaatgaga aaggcgagat agaacaggag cggctggaca aggtgtggcc caagctgagg 2280
gtgctggccc ggtcgtctcc caccgacaag cacacactgg tcaaagggat tatcgacagc 2340
accactggtg agcagcggca ggtggtggct gtgacagggg atggcaccaa cgatgggccg 2400
gccctcaaga aggcggacgt gggcttcgcc atgggcatcg cagggaccga cgtggccaag 2460
gaggcctccg acatcatcct gaccgatgac aacttcacca gcatcgtcaa ggcagtcatg 2520
tggggccgta acgtctatga cagcatctcc aagttcctgc agtttcaact gacggtcaat 2580
gtggtggctg tgatcgtggc cttcacaggt gcctgcatta ctcaggactc tcctctcaaa 2640
gccgtgcaga tgttgtgggt gaacttgatc atggacacat ttgcctctct ggccctggcg 2700
acggagccac ccacagagtc gctgctgctg cggaagccgt acggccgcga caagcccctc 2760
atctcccgca ccatgatgaa gaacattctg ggccacgccg tgtaccagct cgccatcatc 2820
ttcaccctgc tgtttgtcgg ggagctcttc ttcgacatcg acagcgggag gaatgcgccc 2880
ctgcactcgc caccctcaga gcactacacc atcatcttca acacgttcgt catgatgcag 2940
ctctttaacg agatcaacgc ccgcaagatc cacggcgaga ggaacgtgtt cgacggcatc 3000
ttcagcaacc ccatcttctg caccatcgtt ttgggcactt tcgggattca gattgtcatc 3060
gtccagtttg gcgggaagcc cttcagctgc tccccactat ccacagaaca gtggctctgg 3120
tgcctgtttg ttggtgttgg ggagctggtc tggggacagg tcattgccac catccccacc 3180
agccagctca agtgcctgaa ggaagccggg cacgggcccg ggaaggacga gatgaccgac 3240
gaggagctgg ccgaaggcga ggaagagatc gaccatgccg agcgggagct ccgcaggggc 3300
cagatcctct ggttccgggg cctgaaccgg attcagacgc agatccgggt ggtgaaagcg 3360
ttccgtagct cgctctatga aggcctggag aaaccagaat ccaagacctc cattcacaac 3420
ttcatggcca cgcccgagtt tctgatcaat gactacaccc acaacatccc gctcattgac 3480
gacacggacg tggacgagaa cgaggagcgc ctccgggccc ccccgccccc gtcccccaac 3540
cagaacaaca acgccataga cagcggcatc tacctgacca cgcatgtcac caagtcagct 3600
acctcttcag tgttttcctc cagtcccggg agcccgctcc acagcgtgga gacgtccctc 3660
taa 3663
<210>132
<211>3774
<212>DNA
<213>人
<400>132
atggtcgtgg cgctgcggta cgtgtggcct ctcctcctct gcagcccctg cctgcttatc 60
cagatccccg aggaatatga aggacaccat gtgatggagc cacctgtcat cacggaacag 120
tctccacggc gcctggttgt cttccccaca gatgacatca gcctcaagtg tgaggccagt 180
ggcaagcccg aagtgcagtt ccgctggacg agggatggtg tccacttcaa acccaaggaa 240
gagctgggtg tgaccgtgta ccagtcgccc cactctggct ccttcaccat cacgggcaac 300
aacagcaact ttgctcagag gttccagggc atctaccgct gctttgccag caataagctg 360
ggcaccgcca tgtcccatga gatccggctc atggccgagg gtgcccccaa gtggccaaag 420
gagacagtga agcccgtgga ggtggaggaa ggggagtcag tggttctgcc ttgcaaccct 480
cccccaagtg cagagcctct ccggatctac tggatgaaca gcaagatctt gcacatcaag 540
caggacgagc gggtgacgat gggccagaac ggcaacctct actttgccaa tgtgctcacc 600
tccgacaacc actcagacta catctgccac gcccacttcc caggcaccag gaccatcatt 660
cagaaggaac ccattgacct ccgggtcaag gccaccaaca gcatgattga caggaagccg 720
cgcctgctct tccccaccaa ctccagcagc cacctggtgg ccttgcaggg gcagccattg 780
gtcctggagt gcatcgccga gggctttccc acgcccacca tcaaatggct gcgccccagt 840
ggccccatgc cagccgaccg tgtcacctac cagaaccaca acaagaccct gcagctgctg 900
aaagtgggcg aggaggatga tggcgagtac cgctgcctgg ccgagaactc actgggcagt 960
gcccggcatg cgtactatgt caccgtggag gctgccccgt actggctgca caagccccag 1020
agccatctat atgggccagg agagactgcc cgcctggact gccaagtcca gggcaggccc 1080
caaccagagg tcacctggag aatcaacggg atccctgtgg aggagctggc caaagaccag 1140
aagtaccgga ttcagcgtgg cgccctgatc ctgagcaacg tgcagcccag tgacacaatg 1200
gtgacccaat gtgaggcccg caaccggcac gggctcttgc tggccaatgc ctacatctac 1260
gttgtccagc tgccagccaa gatcctgact gcggacaatc agacgtacat ggctgtccag 1320
ggcagcactg cctaccttct gtgcaaggcc ttcggagcgc ctgtgcccag tgttcagtgg 1380
ctggacgagg atgggacaac agtgcttcag gacgaacgct tcttccccta tgccaatggg 1440
accctgggca ttcgagacct ccaggccaat gacaccggac gctacttctg cctggctgcc 1500
aatgaccaaa acaatgttac catcatggct aacctgaagg ttaaagatgc aactcagatc 1560
actcaggggc cccgcagcac aatcgagaag aaaggttcca gggtgacctt cacgtgccag 1620
gcctcctttg acccctcctt gcagcccagc atcacctggc gtggggacgg tcgagacctc 1680
caggagcttg gggacagtga caagtacttc atagaggatg ggcgcctggt catccacagc 1740
ctggactaca gcgaccaggg caactacagc tgcgtggcca gtaccgaact ggatgtggtg 1800
gagagtaggg cacagctctt ggtggtgggg agccctgggc cggtgccacg gctggtgctg 1860
tccgacctgc acctgctgac gcagagccag gtgcgcgtgt cctggagtcc tgcagaagac 1920
cacaatgccc ccattgagaa atatgacatt gaatttgagg acaaggaaat ggcgcctgaa 1980
aaatggtaca gtctgggcaa ggttccaggg aaccagacct ctaccaccct caagctgtcg 2040
ccctatgtcc actacacctt tagggttact gccataaaca aatatggccc cggggagccc 2100
agcccggtct ctgagactgt ggtcacacct gaggcagccc cagagaagaa ccctgtggat 2160
gtgaaggggg aaggaaatga gaccaccaat atggtcatca cgtggaagcc gctccggtgg 2220
atggactgga acgcccccca ggttcagtac cgcgtgcagt ggcgccctca ggggacacga 2280
gggccctggc aggagcagat tgtcagcgac cccttcctgg tggtgtccaa cacgtccacc 2340
ttcgtgccct atgagatcaa agtccaggcc gtcaacagcc agggcaaggg accagagccc 2400
caggtcacta tcggctactc tggagaggac tacccccagg caatccctga gctggaaggc 2460
attgaaatcc tcaactcaag tgccgtgctg gtcaagtggc ggccggtgga cctggcccag 2520
gtcaagggcc acctccgcgg atacaatgtg acgtactgga gggagggcag tcagaggaag 2580
cacagcaaga gacatatcca caaagaccat gtggtggtgc ccgccaacac caccagtgtc 2640
atcctcagtg gcttgcggcc ctatagctcc taccacctgg aggtgcaggc ctttaacggg 2700
cgaggatcgg ggcccgccag cgagttcacc ttcagcaccc cagagggagt gcctggccac 2760
cccgaggcgt tgcacctgga gtgccagtcg aacaccagcc tgctgctgcg ctggcagccc 2820
ccactcagcc acaacggcgt gctcaccggc tacgtgctct cctaccaccc cctggatgag 2880
gggggcaagg ggcaactgtc cttcaacctt cgggaccccg aacttcggac acacaacctg 2940
accgatctca gcccccacct gcggtaccgc ttccagcttc aggccaccac caaagagggc 3000
cctggtgaag ccatcgtacg ggaaggaggc actatggcct tgtctgggat ctcagatttt 3060
ggcaacatct cagccacagc gggtgaaaac tacagtgtcg tctcctgggt ccccaaggag 3120
ggccagtgca acttcaggtt ccatatcttg ttcaaagcct tgggagaaga gaagggtggg 3180
gcttcccttt cgccacagta tgtcagctac aaccagagct cctacacgca gtgggacctg 3240
cagcctgaca ctgactacga gatccacttg tttaaggaga ggatgttccg gcaccaaatg 3300
gctgtgaaga ccaatggcac aggccgcgtg aggctccctc ctgctggctt cgccactgag 3360
ggctggttca tcggctttgt gagtgccatc atcctcctgc tcctcgtcct gctcatcctc 3420
tgcttcatca agcgcagcaa gggcggcaaa tactcagtga aggataagga ggacacccag 3480
gtggactctg aggcccgacc gatgaaagat gagaccttcg gcgagtacag gtccctggag 3540
agtgacaacg aggagaaggc ctttggcagc agccagccat cgctcaacgg ggacatcaag 3600
cccctgggca gtgacgacag cctggccgat tatgggggca gcgtggatgt tcagttcaac 3660
gaggatggtt cgttcattgg ccagtacagt ggcaagaagg agaaggaggc ggcagggggc 3720
aatgacagct caggggccac ttcccccatc aaccctgccg tggccctaga atag 3774
<210>133
<211>3522
<212>DNA
<213>人
<400>133
atgggcgaca tggccaatag ttccatcgag ttccacccca agccccagca gcagcgggat 60
gtcccccagg ctggaggctt tgggtgcacg ctggcggagc tgcgcaccct catggagctg 120
cgaggggccg aggcgctgca gaagatcgag gaggcctacg gggatgtcag cgggctctgc 180
cggaggctga agacctcacc cacagagggc ctggcggaca acaccaatga cctggagaag 240
cgcaggcaga tctacgggca gaacttcatc cccccaaagc aacccaagac cttcctgcag 300
ctggtgtggg aggccctgca ggacgtgacc ctcatcatcc tggaggtggc tgccatcgtc 360
tctctgggcc tctcgttcta tgcgccgcca ggagaggaga gtgaagcctg tgggaatgtg 420
tcgggaggcg cagaagatga gggcgaggcc gaagctggct ggatcgaggg ggctgccatc 480
ctgctgtccg tcatctgtgt ggtgctggtc acggccttca atgactggag caaggagaag 540
cagttccgag gcctgcagag ccgaattgag caggagcaga agttcacggt catccggaac 600
gggcagctcc tccaggtccc cgtggctgcg ctggtggtgg gggacattgc ccaggtcaag 660
tacggcgacc tgctgccagc cgacggcgtg ctcatccagg ccaatgacct caagatcgac 720
gagagctccc tgacgggcga gtctgaccac gtgcgcaagt cagctgacaa agatcccatg 780
ctgctctcag gcactcatgt catggaaggt tctggaagaa tggtggtgac cgccgttggc 840
gtgaattccc agacaggcat catcttcacg ctgcttggag ctggcggaga ggaggaagag 900
aagaaagata agaaaggcaa gcagcaggat ggggccatgg agagtagcca gaccaaagct 960
aagaagcagg atggtgcagt ggccatggag atgcagcccc tgaagagcgc ggagggtggg 1020
gagatggagg agcgggagaa gaagaaagcc aacgcaccca aaaaggagaa gtctgtcctt 1080
caggggaagc tcacaaagct agccgtgcag atcgggaaag cagggctggt gatgtctgcc 1140
atcaccgtca tcatcctggt cctctacttt gtgattgaga cgtttgtcgt ggaaggccgg 1200
acatggctgg cagagtgcac gccggtctat gtacaatact tcgtgaagtt cttcatcatt 1260
ggtgtcactg tgctggtcgt ggctgtccca gagggcctgc ctcttgctgt caccatctcc 1320
ttagcttact ctgtcaagaa aatgatgaaa gacaacaacc tggtgcgcca cctggatgcc 1380
tgcgagacca tgggcaacgc cacagccatc tgctccgaca agacgggcac gctcaccacc 1440
aaccgtatga ccgtggtcca gtcctaccta ggagacaccc actacaaaga gattccggcc 1500
cccagcgccc tgacccctaa gatcctcgac ctcctggtcc atgccatctc catcaacagt 1560
gcctatacca ccaaaatact acctcctgag aaggaaggcg ccctcccacg ccaggtgggc 1620
aataagacgg agtgcgccct gctgggcttc gtcttggacc tgaagcggga cttccagccc 1680
gtgcgcgagc agatcccgga agacaagctt tacaaagtgt acaccttcaa ctcggtccgc 1740
aagtccatga gcacagtcat ccgcatgccc gacggtggct tccgcctctt cagcaagggg 1800
gcctcagaga tcctcttgaa aaagtgcacc aacatcttga acagcaatgg cgaactccgg 1860
ggctttcggc ctcgggaccg ggacgacatg gtgaggaaga tcatcgagcc gatggcttgc 1920
gatggcctcc gcaccatctg catcgcctac cgggacttct ctgcaggcca ggagcccgac 1980
tgggacaacg agaatgaggt cgtgggtgac ctcacctgca tagctgtcgt gggcattgag 2040
gaccctgtgc ggcccgaggt ccctgaagct atccgaaaat gccagcgtgc tggcatcaca 2100
gtccgcatgg tgactgggga caacatcaac acggcccggg ccatcgcagc caaatgcggc 2160
atcatccagc ccggggagga cttcctgtgc ctagaaggga aggagttcaa ccggcggatc 2220
cgcaatgaga aaggcgagat agaacaggag cggctggaca aggtgtggcc caagctgagg 2280
gtgctggccc ggtcgtctcc caccgacaag cacacactgg tcaaagggat tatcgacagc 2340
accactggtg agcagcggca ggtggtggct gtgacagggg atggcaccaa cgatgggccg 2400
gccctcaaga aggcggacgt gggcttcgcc atgggcatcg cagggaccga cgtggccaag 2460
gaggcctccg acatcatcct gaccgatgac aacttcacca gcatcgtcaa ggcagtcatg 2520
tggggccgta acgtctatga cagcatctcc aagttcctgc agtttcaact gacggtcaat 2580
gtggtggctg tgatcgtggc cttcacaggt gcctgcatta ctcaggactc tcctctcaaa 2640
gccgtgcaga tgttgtgggt gaacttgatc atggacacat ttgcctctct ggccctggcg 2700
acggagccac ccacagagtc gctgctgctg cggaagccgt acggccgcga caagcccctc 2760
atctcccgca ccatgatgaa gaacattctg ggccacgccg tgtaccagct cgccatcatc 2820
ttcaccctgc tgtttgtcgg ggagctcttc ttcgacatcg acagcgggag gaatgcgccc 2880
ctgcactcgc caccctcaga gcactacacc atcatcttca acacgttcgt catgatgcag 2940
ctctttaacg agatcaacgc ccgcaagatc cacggcgaga ggaacgtgtt cgacggcatc 3000
ttcagcaacc ccatcttctg caccatcgtt ttgggcactt tcgggattca gattgtcatc 3060
gtccagtttg gcgggaagcc cttcagctgc tccccactat ccacagaaca gtggctctgg 3120
tgcctgtttg ttggtgttgg ggagctggtc tggggacagg tcattgccac catccccacc 3180
agccagctca agtgcctgaa ggaagccggg cacgggcccg ggaaggacga gatgaccgac 3240
gaggagctgg ccgaaggcga ggaagagatc gaccatgccg agcgggagct ccgcaggggc 3300
cagatcctct ggttccgggg cctgaaccgg attcagacgc agatggaggt agtgagtacc 3360
ttcaagagaa gcggttcagt tcagggtgct gtgcgccggc ggtcttcggt cctcagccag 3420
cttcatgacg taaccaatct ttctacccct actcacgcaa ttctctctgc tgccaatcct 3480
accagtgctg ctgggaatcc gggtggtgaa agcgttccgt ag 3522
<210>134
<211>3774
<212>DNA
<213>人
<400>134
atggtcgtgg cgctgcggta cgtgtggcct ctcctcctct gcagcccctg cctgcttatc 60
cagatccccg aggaatatga aggacaccat gtgatggagc cacctgtcat cacggaacag 120
tctccacggc gcctggttgt cttccccaca gatgacatca gcctcaagtg tgaggccagt 180
ggcaagcccg aagtgcagtt ccgctggacg agggatggtg tccacttcaa acccaaggaa 240
gagctgggtg tgaccgtgta ccagtcgccc cactctggct ccttcaccat cacgggcaac 300
aacagcaact ttgctcagag gttccagggc atctaccgct gctttgccag caataagctg 360
ggcaccgcca tgtcccatga gatccggctc atggccgagg gtgcccccaa gtggccaaag 420
gagacagtga agcccgtgga ggtggaggaa ggggagtcag tggttctgcc ttgcaaccct 480
cccccaagtg cagagcctct ccggatctac tggatgaaca gcaagatctt gcacatcaag 540
caggacgagc gggtgacgat gggccagaac ggcaacctct actttgccaa tgtgctcacc 600
tccgacaacc actcagacta catctgccac gcccacttcc caggcaccag gaccatcatt 660
cagaaggaac ccattgacct ccgggtcaag gccaccaaca gcatgattga caggaagccg 720
cgcctgctct tccccaccaa ctccagcagc cacctggtgg ccttgcaggg gcagccattg 780
gtcctggagt gcatcgccga gggctttccc acgcccacca tcaaatggct gcgccccagt 840
ggccccatgc cagccgaccg tgtcacctac cagaaccaca acaagaccct gcagctgctg 900
aaagtgggcg aggaggatga tggcgagtac cgctgcctgg ccgagaactc actgggcagt 960
gcccggcatg cgtactatgt caccgtggag gctgccccgt actggctgca caagccccag 1020
agccatctat atgggccagg agagactgcc cgcctggact gccaagtcca gggcaggccc 1080
caaccagagg tcacctggag aatcaacggg atccctgtgg aggagctggc caaagaccag 1140
aagtaccgga ttcagcgtgg cgccctgatc ctgagcaacg tgcagcccag tgacacaatg 1200
gtgacccaat gtgaggcccg caaccggcac gggctcttgc tggccaatgc ctacatctac 1260
gttgtccagc tgccagccaa gatcctgact gcggacaatc agacgtacat ggctgtccag 1320
ggcagcactg cctaccttct gtgcaaggcc ttcggagcgc ctgtgcccag tgttcagtgg 1380
ctggacgagg atgggacaac agtgcttcag gacgaacgct tcttccccta tgccaatggg 1440
accctgggca ttcgagacct ccaggccaat gacaccggac gctacttctg cctggctgcc 1500
aatgaccaaa acaatgttac catcatggct aacctgaagg ttaaagatgc aactcagatc 1560
actcaggggc cccgcagcac aatcgagaag aaaggttcca gggtgacctt cacgtgccag 1620
gcctcctttg acccctcctt gcagcccagc atcacctggc gtggggacgg tcgagacctc 1680
caggagcttg gggacagtga caagtacttc atagaggatg ggcgcctggt catccacagc 1740
ctggactaca gcgaccaggg caactacagc tgcgtggcca gtaccgaact ggatgtggtg 1800
gagagtaggg cacagctctt ggtggtgggt aaccctgggc cggtgccacg gctggtgctg 1860
tccgacctgc acctgctgac gcagagccag gtgcgcgtgt cctggagtcc tgcagaagac 1920
cacaatgccc ccattgagaa atatgacatt gaatttgagg acaaggaaat ggcgcctgaa 1980
aaatggtaca gtctgggcaa ggttccaggg aaccagacct ctaccaccct caagctgtcg 2040
ccctatgtcc actacacctt tagggttact gccataaaca aatatggccc cggggagccc 2100
agcccggtct ctgagactgt ggtcacacct gaggcagccc cagagaagaa ccctgtggat 2160
gtgaaggggg aaggaaatga gaccaccaat atggtcatca cgtggaagcc gctccggtgg 2220
atggactgga acgcccccca ggttcagtac cgcgtgcagt ggcgccctca ggggacacga 2280
gggccctggc aggagcagat tgtcagcgac cccttcctgg tggtgtccaa cacgtccacc 2340
ttcgtgccct atgagatcaa agtccaggcc gtcaacagcc agggcaaggg accagagccc 2400
caggtcacta tcggctactc tggagaggac tacccccagg caatccctga gctggaaggc 2460
attgaaatcc tcaactcaag tgccgtgctg gtcaagtggc ggccggtgga cctggcccag 2520
gtcaagggcc acctccgcgg atacaatgtg acgtactgga gggagggcag tcagaggaag 2580
cacagcaaga gacatatcca caaagaccat gtggtggtgc ccgccaacac caccagtgtc 2640
atcctcagtg gcttgcggcc ctatagctcc taccacctgg aggtgcaggc ctttaacggg 2700
cgaggatcgg ggcccgccag cgagttcacc ttcagcaccc cagagggagt gcctggccac 2760
cccgaggcgt tgcacctgga gtgccagtcg aacaccagcc tgctgctgcg ctggcagccc 2820
ccactcagcc acaacggcgt gctcaccggc tacgtgctct cctaccaccc cctggatgag 2880
gggggcaagg ggcaactgtc cttcaacctt cgggaccccg aacttcggac acacaacctg 2940
accgatctca gcccccacct gcggtaccgc ttccagcttc aggccaccac caaagagggc 3000
cctggtgaag ccatcgtacg ggaaggaggc actatggcct tgtctgggat ctcagatttt 3060
ggcaacatct cagccacagc gggtgaaaac tacagtgtcg tctcctgggt ccccaaggag 3120
ggccagtgca acttcaggtt ccatatcttg ttcaaagcct tgggagaaga gaagggtggg 3180
gcttcccttt cgccacagta tgtcagctac aaccagagct cctacacgca gtgggacctg 3240
cagcctgaca ctgactacga gatccacttg tttaaggaga ggatgttccg gcaccaaatg 3300
gctgtgaaga ccaatggcac aggccgcgtg aggctccctc ctgctggctt cgccactgag 3360
ggctggttca tcggctttgt gagtgccatc atcctcctgc tcctcgtcct gctcatcctc 3420
tgcttcatca agcgcagcaa gggcggcaaa tactcagtga aggataagga ggacacccag 3480
gtggactctg aggcccgacc gatgaaagat gagaccttcg gcgagtacag gtccctggag 3540
agtgacaacg aggagaaggc ctttggcagc agccagccat cgctcaacgg ggacatcaag 3600
cccctgggca gtgacgacag cctggccgat tatgggggca gcgtggatgt tcagttcaac 3660
gaggatggtt cgttcattgg ccagtacagt ggcaagaagg agaaggaggc ggcagggggc 3720
aatgacagct caggggccac ttcccccatc aaccctgccg tggccctaga atag 3774
<210>135
<211>3387
<212>DNA
<213>人
<400>135
atgggcgaca tggccaatag ttccatcgag ttccacccca agccccagca gcagcgggat 60
gtcccccagg ctggaggctt tgggtgcacg ctggcggagc tgcgcaccct catggagctg 120
cgaggggccg aggcgctgca gaagatcgag gaggcctacg gggatgtcag cgggctctgc 180
cggaggctga agacctcacc cacagagggc ctggcggaca acaccaatga cctggagaag 240
cgcaggcaga tctacgggca gaacttcatc cccccaaagc aacccaagac cttcctgcag 300
ctggtgtggg aggccctgca ggacgtgacc ctcatcatcc tggaggtggc tgccatcgtc 360
tctctgggcc tctcgttcta tgcgccgcca ggagaggaga gtgaagcctg tgggaatgtg 420
tcgggaggcg cagaagatga gggcgaggcc gaagctggct ggatcgaggg ggctgccatc 480
ctgctgtccg tcatctgtgt ggtgctggtc acggccttca atgactggag caaggagaag 540
cagttccgag gcctgcagag ccgaattgag caggagcaga agttcacggt catccggaac 600
gggcagctcc tccaggtccc cgtggctgcg ctggtggtgg gggacattgc ccaggtcaag 660
tacggcgacc tgctgccagc cgacggcgtg ctcatccagg ccaatgacct caagatcgac 720
gagagctccc tgacgggcga gtctgaccac gtgcgcaagt cagctgacaa agatcccatg 780
ctgctctcag gcactcatgt catggaaggt tctggaagaa tggtggtgac cgccgttggc 840
gtgaattccc agacaggcat catcttcacg ctgcttggag ctggcggaga ggaggaagag 900
aagaaagata agaaaggcaa gcagcaggat ggggccatgg agagtagcca gaccaaagct 960
aagaagcagg atggtgcagt ggccatggag atgcagcccc tgaagagcgc ggagggtggg 1020
gagatggagg agcgggagaa gaagaaagcc aacgcaccca aaaaggagaa gtctgtcctt 1080
caggggaagc tcacaaagct agccgtgcag atcgggaaag cagggctggt gatgtctgcc 1140
atcaccgtca tcatcctggt cctctacttt gtgattgaga cgtttgtcgt ggaaggccgg 1200
acatggctgg cagagtgcac gccggtctat gtacaatact tcgtgaagtt cttcatcatt 1260
ggtgtcactg tgctggtcgt ggctgtccca gagggcctgc ctcttgctgt caccatctcc 1320
ttagcttact ctgtcaagaa aatgatgaaa gacaacaacc tggtgcgcca cctggatgcc 1380
tgcgagacca tgggcaacgc cacagccatc tgctccgaca agacgggcac gctcaccacc 1440
aaccgtatga ccgtggtcca gtcctaccta ggagacaccc actacaaaga gattccggcc 1500
cccagcgccc tgacccctaa gatcctcgac ctcctggtcc atgccatctc catcaacagt 1560
gcctatacca ccaaaatact acctcctgag aaggaaggcg ccctcccacg ccaggtgggc 1620
aataagacgg agtgcgccct gctgggcttc gtcttggacc tgaagcggga cttccagccc 1680
gtgcgcgagc agatcccgga agacaagctt tacaaagtgt acaccttcaa ctcggtccgc 1740
aagtccatga gcacagtcat ccgcatgccc gacggtggct tccgcctctt cagcaagggg 1800
gcctcagaga tcctcttgaa aaagtgcacc aacatcttga acagcaatgg cgaactccgg 1860
ggctttcggc ctcgggaccg ggacgacatg gtgaggaaga tcatcgagcc gatggcttgc 1920
gatggcctcc gcaccatctg catcgcctac cgggacttct ctgcaggcca ggagcccgac 1980
tgggacaacg agaatgaggt cgtgggtgac ctcacctgca tagctgtcgt gggcattgag 2040
gaccctgtgc ggcccgaggt ccctgaagct atccgaaaat gccagcgtgc tggcatcaca 2100
gtccgcatgg tgactgggga caacatcaac acggcccggg ccatcgcagc caaatgcggc 2160
atcatccagc ccggggagga cttcctgtgc ctagaaggga aggagttcaa ccggcggatc 2220
cgcaatgaga aaggcgagat agaacaggag cggctggaca aggtgtggcc caagctgagg 2280
gtgctggccc ggtcgtctcc caccgacaag cacacactgg tcaaagggat tatcgacagc 2340
accactggtg agcagcggca ggtggtggct gtgacagggg atggcaccaa cgatgggccg 2400
gccctcaaga aggcggacgt gggcttcgcc atgggcatcg cagggaccga cgtggccaag 2460
gaggcctccg acatcatcct gaccgatgac aacttcacca gcatcgtcaa ggcagtcatg 2520
tggggccgta acgtctatga cagcatctcc aagttcctgc agtttcaact gacggtcaat 2580
gtggtggctg tgatcgtggc cttcacaggt gcctgcatta ctcaggactc tcctctcaaa 2640
gccgtgcaga tgttgtgggt gaacttgatc atggacacat ttgcctctct ggccctggcg 2700
acggagccac ccacagagtc gctgctgctg cggaagccgt acggccgcga caagcccctc 2760
atctcccgca ccatgatgaa gaacattctg ggccacgccg tgtaccagct cgccatcatc 2820
ttcaccctgc tgtttgtcgg ggagctcttc ttcgacatcg acagcgggag gaatgcgccc 2880
ctgcactcgc caccctcaga gcactacacc atcatcttca acacgttcgt catgatgcag 2940
ctctttaacg agatcaacgc ccgcaagatc cacggcgaga ggaacgtgtt cgacggcatc 3000
ttcagcaacc ccatcttctg caccatcgtt ttgggcactt tcgggattca gattgtcatc 3060
gtccagtttg gcgggaagcc cttcagctgc tccccactat ccacagaaca gtggctctgg 3120
tgcctgtttg ttggtgttgg ggagctggtc tggggacagg tcattgccac catccccacc 3180
agccagctca agtgcctgaa ggaagccggg cacgggcccg ggaaggacga gatgaccgac 3240
gaggagctgg ccgaaggcga ggaagagatc gaccatgccg agcgggagct ccgcaggggc 3300
cagatcctct ggttccgggg cctgaaccgg attcagacgc aggtgtgttg gagaggaaaa 3360
acaaggttga gaactatgaa gtacttc 3387
<210>136
<211>3747
<212>DNA
<213>人
<400>136
atggtcgtgg cgctgcggta cgtgtggcct ctcctcctct gcagcccctg cctgcttatc 60
cagatccccg aggaattgat ggagccacct gtcatcacgg aacagtctcc acggcgcctg 120
gttgtcttcc ccacagatga catcagcctc aagtgtgagg ccagtggcaa gcccgaagtg 180
cagttccgct ggacgaggga tggtgtccac ttcaaaccca aggaagagct gggtgtgacc 240
gtgtaccagt cgccccactc tggctccttc accatcacgg gcaacaacag caactttgct 300
cagaggttcc agggcatcta ccgctgcttt gccagcaata agctgggcac cgccatgtcc 360
catgagatcc ggctcatggc cgagggtgcc cccaagtggc caaaggagac agtgaagccc 420
gtggaggtgg aggaagggga gtcagtggtt ctgccttgca accctccccc aagtgcagag 480
cctctccgga tctactggat gaacagcaag atcttgcaca tcaagcagga cgagcgggtg 540
acgatgggcc agaacggcaa cctctacttt gccaatgtgc tcacctccga caaccactca 600
gactacatct gccacgccca cttcccaggc accaggacca tcattcagaa ggaacccatt 660
gacctccggg tcaaggccac caacagcatg attgacagga agccgcgcct gctcttcccc 720
accaactcca gcagccacct ggtggccttg caggggcagc cattggtcct ggagtgcatc 780
gccgagggct ttcccacgcc caccatcaaa tggctgcgcc ccagtggccc catgccagcc 840
gaccgtgtca cctaccagaa ccacaacaag accctgcagc tgctgaaagt gggcgaggag 900
gatgatggcg agtaccgctg cctggccgag aactcactgg gcagtgcccg gcatgcgtac 960
tatgtcaccg tggaggctgc cccgtactgg ctgcacaagc cccagagcca tctatatggg 1020
ccaggagaga ctgcccgcct ggactgccaa gtccagggca ggccccaacc agaggtcacc 1080
tggagaatca acgggatccc tgtggaggag ctggccaaag accagaagta ccggattcag 1140
cgtggcgccc tgatcctgag caacgtgcag cccagtgaca caatggtgac ccaatgtgag 1200
gcccgcaacc ggcacgggct cttgctggcc aatgcctaca tctacgttgt ccagctgcca 1260
gccaagatcc tgactgcgga caatcagacg tacatggctg tccagggcag cactgcctac 1320
cttctgtgca aggccttcgg agcgcctgtg cccagtgttc agtggctgga cgaggatggg 1380
acaacagtgc ttcaggacga acgcttcttc ccctatgcca atgggaccct gggcattcga 1440
gacctccagg ccaatgacac cggacgctac ttctgcctgg ctgccaatga ccaaaacaat 1500
gttaccatca tggctaacct gaaggttaaa gatgcaactc agatcactca ggggccccgc 1560
agcacaatcg agaagaaagg ttccagggtg accttcacgt gccaggcctc ctttgacccc 1620
tccttgcagc ccagcatcac ctggcgtggg gacggtcgag acctccagga gcttggggac 1680
agtgacaagt acttcataga ggatgggcgc ctggtcatcc acagcctgga ctacagcgac 1740
cagggcaact acagctgcgt ggccagtacc gaactggatg tggtggagag tagggcacag 1800
ctcttggtgg tggggagccc tgggccggtg ccacggctgg tgctgtccga cctgcacctg 1860
ctgacgcaga gccaggtgcg cgtgtcctgg agtcctgcag aagaccacaa tgcccccatt 1920
gagaaatatg acattgaatt tgaggacaag gaaatggcgc ctgaaaaatg gtacagtctg 1980
ggcaaggttc cagggaacca gacctctacc accctcaagc tgtcgcccta tgtccactac 2040
acctttaggg ttactgccat aaacaaatat ggccccgggg agcccagccc ggtctctgag 2100
actgtggtca cacctgaggc agccccagag aagaaccctg tggatgtgaa gggggaagga 2160
aatgagacca ccaatatggt catcacgtgg aagccgctcc ggtggatgga ctggaacgcc 2220
ccccaggttc agtaccgcgt gcagtggcgc cctcagggga cacgagggcc ctggcaggag 2280
cagattgtca gcgacccctt cctggtggtg tccaacacgt ccaccttcgt gccctatgag 2340
atcaaagtcc aggccgtcaa cagccagggc aagggaccag agccccaggt cactatcggc 2400
tactctggag aggactaccc ccaggcaatc cctgagctgg aaggcattga aatcctcaac 2460
tcaagtgccg tgctggtcaa gtggcggccg gtggacctgg cccaggtcaa gggccacctc 2520
cgcggataca atgtgacgta ctggagggag ggcagtcaga ggaagcacag caagagacat 2580
atccacaaag accatgtggt ggtgcccgcc aacaccacca gtgtcatcct cagtggcttg 2640
cggccctata gctcctacca cctggaggtg caggccttta acgggcgagg atcggggccc 2700
gccagcgagt tcaccttcag caccccagag ggagtgcctg gccaccccga ggcgttgcac 2760
ctggagtgcc agtcgaacac cagcctgctg ctgcgctggc agcccccact cagccacaac 2820
ggcgtgctca ccggctacgt gctctcctac caccccctgg atgagggggg caaggggcaa 2880
ctgtccttca accttcggga ccccgaactt cggacacaca acctgaccga tctcagcccc 2940
cacctgcggt accgcttcca gcttcaggcc accaccaaag agggccctgg tgaagccatc 3000
gtacgggaag gaggcactat ggccttgtct gggatctcag attttggcaa catctcagcc 3060
acagcgggtg aaaactacag tgtcgtctcc tgggtcccca aggagggcca gtgcaacttc 3120
aggttccata tcttgttcaa agccttggga gaagagaagg gtggggcttc cctttcgcca 3180
cagtatgtca gctacaacca gagctcctac acgcagtggg acctgcagcc tgacactgac 3240
tacgagatcc acttgtttaa ggagaggatg ttccggcacc aaatggctgt gaagaccaat 3300
ggcacaggcc gcgtgaggct ccctcctgct ggcttcgcca ctgagggctg gttcatcggc 3360
tttgtgagtg ccatcatcct cctgctcctc gtcctgctca tcctctgctt catcaagcgc 3420
agcaagggcg gcaaatactc agtgaaggat aaggaggaca cccaggtgga ctctgaggcc 3480
cgaccgatga aagatgagac cttcggcgag tacagtgaca acgaggagaa ggcctttggc 3540
agcagccagc catcgctcaa cggggacatc aagcccctgg gcagtgacga cagcctggcc 3600
gattatgggg gcagcgtgga tgttcagttc aacgaggatg gttcgttcat tggccagtac 3660
agtggcaaga aggagaagga ggcggcaggg ggcaatgaca gctcaggggc cacttccccc 3720
atcaaccctg ccgtggccct agaatag 3747
<210>137
<211>2433
<212>DNA
<213>牛
<400>137
gaggaggagg aggacgccgc cgtgagttct ccgccatgaa cctgaggggc cttttccagg 60
acttcaaccc gagtaaattc ctcatctatg cctgtctact gctgttctct gtgttgctgg 120
cccttcgtct agatggcatc attcagtgga gttactgggc tgtttttgct ccaatatggc 180
tgtggaagtt aatggtcatt gttggagcct cagttggaac tggagtctgg gcacggaatc 240
cccaatatcg agcagaaggg gaaacatgtg tggagttcaa ggccatgcta attgcagtgg 300
gcatccactt gctgttgctg atgtttgaag tgctggtgtg cgacaggatt gagagaggca 360
gccacttctg gctcctggtc ttcatgccac tcttcttcgt ttcccccgtg tctgtggcag 420
cttgtgtttg gggctttcgc catgacaggt cactggagtt agaaatcctg tgttctgtca 480
acattctcca gtttatattc attgccttaa gactggacaa gatcattcac tggccctggc 540
ttgtcgtgtg tgtccccttg tggattctca tgtcgtttct gtgtctggta gtcctctact 600
acatcgtgtg gtccgtcctg ttcctgcgtt ccatggatgt gatcgcagag cagaggagga 660
cacacatcac catggcgcta agctggatga ccatcgttgt gccactcctt acttttgaga 720
tcctgctggt tcataagctg gacggccaca atgcattctc ctgtatcccc atatttgtcc 780
ccctttggct ttccttgatc actctgatgg caaccacctt cggacagaaa ggcggaaacc 840
actggtggtt tgggattcgc aaggatttct gtcagtttct gcttgaaatc tgcccgtttt 900
tgagagaata tggaaacatc tcctacgacc tccaccatga aggtagcgag gaaactgaag 960
aaacgccagt tccagaacct cctaagatcg ctcctatgtt tcgaaagaag acccgggtgg 1020
ttatcaccca gagccctggg aagtacgtcc tcccacctcc caaattaaat atcgaaatgc 1080
cagattagac cgtgttccca gggcagatca agagtgcacc tggcccgccc tcttttccac 1140
cttcttctgc ctccattcac cccctccctc ccaccctgaa ctggagctgg agctgggtct 1200
ccagggactt ccatctcatg ccttgtttgc actcaatgcc tacccagtga ctcaccgcca 1260
cgggacatgc ggctggcagg tgcctggaac atgcagcgtg gtgtagggtg cacatcagcg 1320
gatttggacc tgatggaggg agcatatgga gacagaggaa acaactccca gtgggcaggt 1380
gccttcagag ctggcttggg cccaagaagg aatggccacc cagctggttt tctaagtgtg 1440
aaaattccca tcaaaagtgt tattgaaaaa tgtattattg aaccaagcca gcctggccac 1500
ttagctcaga aactcctgtt gtggtgtggt caggggccct gactaagcct caggcctcac 1560
atgcacccac accactgtca ctggccatgc tcctgccatg cacatcattt ctgggttttt 1620
actgacccca ttggtgagcc ctttctaatg gagtgactcc gtgcctgtat agtatttata 1680
caaatatttt agcgttgtaa tataccgtgt taaatcctag ttctgtacag tatattctgt 1740
taaagtattt ttttacaagc ttgtactgga gacatacatg ttctgttgca gaagtagaag 1800
ccagtagcac cgcacccctg tcctgaccac tggagtgcta cccccttcat gggacattgc 1860
catctcctct tcagtttctc catatacata ctagctgctg ctgccagaac tgccacagta 1920
agcaagaaat ggtttgtact ttttctccca cactgggaac actgacttgc agaaaaccgt 1980
aaagcacgcc tgggagctgg agcgctggac aaggtgccaa gactgggaat gtccagcagc 2040
gtgcacaggt tgagatgtgg ggcttgttgt ccatcacaca ctgcacctat gcttttagct 2100
aggagcttgg ggtagagccg agagtcagaa ggaaaaaagc agatgcgatg caaacaagat 2160
ggccatgagt aaaagagggt aaaaggagcc ctggctttgt cacccaggag caggggggag 2220
agggcagcta ctgccttgtg tgaaccaggc tctgctgatg tacactgcac caccactcca 2280
tcctgacacc agcctggaac aagcccgtgc tctcttcagg ggcacacttg gaatggtgtt 2340
gcctttcctg cttggtatgt aacacatgta gcccagtcta ctctttttct cccctttagc 2400
tgttcaataa actagttctt cattttccat gtg 2433
<210>138
<211>350
<212>PRT
<213>牛
<400>138
Met Asn Leu Arg Gly Leu Phe Gln Asp Phe Asn Pro Ser Lys Phe Leu
1 5 10 15
Ile Tyr Ala Cys Leu Leu Leu Phe Ser Val Leu Leu Ala Leu Arg Leu
20 25 30
Asp Gly Ile Ile Gln Trp Ser Tyr Trp Ala Val Phe Ala Pro Ile Trp
35 40 45
Leu Trp Lys Leu Met Val Ile Val Gly Ala Ser Val Gly Thr Gly Val
50 55 60
Trp Ala Arg Asn Pro Gln Tyr Arg Ala Glu Gly Glu Thr Cys Val Glu
65 70 75 80
Phe Lys Ala Met Leu Ile Ala Val Gly Ile His Leu Leu Leu Leu Met
85 90 95
Phe Glu Val Leu Val Cys Asp Arg Ile Glu Arg Gly Ser His Phe Trp
100 105 110
Leu Leu Val Phe Met Pro Leu Phe Phe Val Ser Pro Val Ser Val Ala
115 120 125
Ala Cys Val Trp Gly Phe Arg His Asp Arg Ser Leu Glu Leu Glu Ile
130 135 140
Leu Cys Ser Val Asn Ile Leu Gln Phe Ile Phe Ile Ala Leu Arg Leu
145 150 155 160
Asp Lys Ile Ile His Trp Pro Trp Leu Val Val Cys Val Pro Leu Trp
165 170 175
Ile Leu Met Ser Phe Leu Cys Leu Val Val Leu Tyr Tyr Ile Val Trp
180 185 190
Ser Val Leu Phe Leu Arg Ser Met Asp Val Ile Ala Glu Gln Arg Arg
195 200 205
Thr His Ile Thr Met Ala Leu Ser Trp Met Thr Ile Val Val Pro Leu
210 215 220
Leu Thr Phe Glu Ile Leu Leu Val His Lys Leu Asp Gly His Asn Ala
225 230 235 240
Phe Ser Cys Ile Pro Ile Phe Val Pro Leu Trp Leu Ser Leu Ile Thr
245 250 255
Leu Met Ala Thr Thr Phe Gly Gln Lys Gly Gly Asn His Trp Trp Phe
260 265 270
Gly Ile Arg Lys Asp Phe Cys Gln Phe Leu Leu Glu Ile Cys Pro Phe
275 280 285
Leu Arg Glu Tyr Gly Asn Ile Ser Tyr Asp Leu His His Glu Gly Ser
290 295 300
Glu Glu Thr Glu Glu Thr Pro Val Pro Glu Pro Pro Lys Ile Ala Pro
305 310 315 320
Met Phe Arg Lys Lys Thr Arg Val Val Ile Thr Gln Ser Pro Gly Lys
325 330 335
Tyr Val Leu Pro Pro Pro Lys Leu Asn Ile Glu Met Pro Asp
340 345 350
<210>139
<211>2330
<212>DNA
<213>牛
<400>139
cccccggtcc gccgtcctcg gcccccggcg ggcccgcgcc ttcggggcct ttatcccccc 60
ctgcgccgct ggcgaccccg cgcctgtccg cccgcccgcc cccgcgggcc gccgtgcccc 120
cggccatggc caacaagagc acggagaacg gcatctacag cgtgtccggc gaggagaaga 180
agggccccct aatcgcgccc gggcccgacg gagccccggc caagggcgac ggccccgcag 240
ccctgggggc gcccggcagc ctcctggccg ttccgccgcg cgagacctgg acgcgccaga 300
tggacttcat catgtcgtgc gtgggctttg ccgtgggcct gggcaacgtg tggcgcttcc 360
cctacctgtg ctacaagaac ggcggaggtg tgttccttat tccctacatc ctgatcgccc 420
tgattggagg aatccccatc ttcttcttgg agatctcgct gggccagttc atgaaggccg 480
gcagcatcaa cgtctggaat atctgccccc tgttcaaagg cctgggctac gcctccatgg 540
tgatcgtctt ctactgcaac acctattaca tcatggtgct ggcctggggc ttctattatc 600
tggtgaagtc cttcaccacc acgctgccct gggccacgtg tggccacacg tggaacactc 660
ccgattgcgt ggagatcttc cgccacgaag actgtgccaa tgccaccatg gccaacctca 720
catgtgacca gcttgctgac cgccggtccc cggtcatcga gttctgggag aacaaagtct 780
tgcggctctc tgaagggctg gaggtgccag gggccctcaa ctgggaggtg accctgtgtc 840
tgctgacctg ctgggtgctg gtctacttct gtgtctggaa gggggtcaag tcaacaggca 900
agatcgtgta tttcaccgct acattcccct atgtggtcct cgttgtgctg ctggtgcgcg 960
gagtgctgct acctggcgct ttggatggca tcatctacta tctcaagcct gactggtcaa 1020
agctggcatc ccctcaggta tggatcgacg cagggacaca gatcttcttc tcttacgcca 1080
tcggcttggg ggccctcacc gccctgggca gctacaatcg cttcaacaac aactgctaca 1140
aggatgccat catactcgcc ctcatcaaca gcgggaccag cttctttgca ggcttcgtgg 1200
tgttctccat cctgggcttc atggccacag aacagggcgt gcacatctcc aaggtagcag 1260
aatcagggcc tggcctggct ttcatcgcct atccgcgggc cgtcacgctg atgcccgtgg 1320
ccccactctg ggcagctctg ttcttcttca tgctgttgct gcttggtctg gacagccagt 1380
ttgtaggtgt cgaaggcttc atcactggct tgctggacct cctcccagcc tcctactact 1440
tccgattcca aagggagatc tccgtggccc tctgttgcac catctgcttt gtcatcgacc 1500
tctccatggt gactgatggc gggatgtatg tcttccagct gtttgactac tactcagcca 1560
gtggcaccac actgctctgg caggccttct gggagtgtgt ggtggtcgcc tgggtgtacg 1620
gagctgatcg cttcatggat gatgtggcct gcatgatcgg gtaccgacct tgcccctgga 1680
tgaaatggtg ctggtctttc ttcaccccac tggtgtgcat gggcatcttc atcttcaatg 1740
tggtctacca tgagccgctg gtctacaaca atacctacgt gtacccgtgg tggggcgagg 1800
ccgtgggctg ggcctttgcg ctctcctcca tgctatgtgt gcccctccac ctcctgggct 1860
gcctcctcag ggccaagggg accatggctg agcgctggca gcacctgacg cagcccatct 1920
ggggcctcca ccacctggaa tacagagctc aagactcgga tgtcaggggc ctgaccaccc 1980
tgaccccagt gtctgagagc agcaaggtgg tggtggtgga aagcgtcatg tgacgggccc 2040
ccggcaccag ctccccctct tgtagccata gcatccctgc tttagccccc cccacccctc 2100
ccggggggct tgcctttccc tgccactcaa cgggggtctg cctgcctggg gtggggggag 2160
gggaggaagc accagagtgc ttataactca cttttttttc catttttaat aaaacaccaa 2220
aaaaatacca caacccacca aaaatagatg cctccccgcc cccataacca agctggtgca 2280
cacgctgttc cccagcgcac cgcccccccc cgcccctgct agtacccact 2330
<210>140
<211>635
<212>PRT
<213>牛
<400>140
Met Ala Asn Lys Ser Thr Glu Asn Gly Ile Tyr Ser Val Ser Gly Glu
1 5 10 15
Glu Lys Lys Gly Pro Leu Ile Ala Pro Gly Pro Asp Gly Ala Pro Ala
20 25 30
Lys Gly Asp Gly Pro Ala Ala Leu Gly Ala Pro Gly Ser Leu Leu Ala
35 40 45
Val Pro Pro Arg Glu Thr Trp Thr Arg Gln Met Asp Phe Ile Met Ser
50 55 60
Cys Val Gly Phe Ala Val Gly Leu Gly Asn Val Trp Arg Phe Pro Tyr
65 70 75 80
Leu Cys Tyr Lys Asn Gly Gly Gly Val Phe Leu Ile Pro Tyr Ile Leu
85 90 95
Ile Ala Leu Ile Gly Gly Ile Pro Ile Phe Phe Leu Glu Ile Ser Leu
100 105 110
Gly Gln Phe Met Lys Ala Gly Ser Ile Asn Val Trp Asn Ile Cys Pro
115 120 125
Leu Phe Lys Gly Leu Gly Tyr Ala Ser Met Val Ile Val Phe Tyr Cys
130 135 140
Asn Thr Tyr Tyr Ile Met Val Leu Ala Trp Gly Phe Tyr Tyr Leu Val
145 150 155 160
Lys Ser Phe Thr Thr Thr Leu Pro Trp Ala Thr Cys Gly His Thr Trp
165 170 175
Asn Thr Pro Asp Cys Val Glu Ile Phe Arg His Glu Asp Cys Ala Asn
180 185 190
Ala Thr Met Ala Asn Leu Thr Cys Asp Gln Leu Ala Asp Arg Arg Ser
195 200 205
Pro Val Ile Glu Phe Trp Glu Asn Lys Val Leu Arg Leu Ser Glu Gly
210 215 220
Leu Glu Val Pro Gly Ala Leu AsnTrp Glu Val Thr Leu Cys Leu Leu
225 230 235 240
Thr Cys Trp Val Leu Val Tyr Phe Cys Val Trp Lys Gly Val Lys Ser
245 250 255
Thr Gly Lys Ile Val Tyr Phe Thr Ala Thr Phe Pro Tyr Val Val Leu
260 265 270
Val Val Leu Leu Val Arg Gly Val Leu Leu Pro Gly Ala Leu Asp Gly
275 280 285
Ile Ile Tyr Tyr Leu Lys Pro Asp Trp Ser Lys Leu Ala Ser Pro Gln
290 295 300
Val Trp Ile Asp Ala Gly Thr Gln Ile Phe Phe Ser Tyr Ala Ile Gly
305 310 315 320
Leu Gly Ala Leu Thr Ala Leu Gly Ser Tyr Asn Arg Phe Asn Asn Asn
325 330 335
Cys Tyr Lys Asp Ala Ile Ile Leu Ala Leu Ile Asn Ser Gly Thr Ser
340 345 350
Phe Phe Ala Gly Phe Val Val Phe Ser Ile Leu Gly Phe Met Ala Thr
355 360 365
Glu Gln Gly Val His Ile Ser Lys Val Ala Glu Ser Gly Pro Gly Leu
370 375 380
Ala Phe Ile Ala Tyr Pro Arg Ala Val Thr Leu Met Pro Val Ala Pro
385 390 395 400
Leu Trp Ala Ala Leu Phe Phe Phe Met Leu Leu Leu Leu Gly Leu Asp
405 410 415
Ser Gln Phe Val Gly Val Glu Gly Phe Ile Thr Gly Leu Leu Asp Leu
420 425 430
Leu Pro Ala Ser Tyr Tyr Phe Arg Phe Gln Arg Glu Ile Ser Val Ala
435 440 445
Leu Cys Cys Thr Ile Cys Phe Val Ile Asp Leu Ser Met Val Thr Asp
450 455 460
Gly Gly Met Tyr Val Phe Gln Leu Phe Asp Tyr Tyr Ser Ala Ser Gly
465 470 475 480
Thr Thr Leu Leu Trp Gln Ala Phe Trp Glu Cys Val Val Val Ala Trp
485 490 495
Val Tyr Gly Ala Asp Arg Phe Met Asp Asp Val Ala Cys Met Ile Gly
500 505 510
Tyr Arg Pro Cys Pro Trp Met Lys Trp Cys Trp Ser Phe Phe Thr Pro
515 520 525
Leu Val Cys Met Gly Ile Phe Ile Phe Asn Val Val Tyr His Glu Pro
530 535 540
Leu Val Tyr Asn Asn Thr Tyr Val Tyr Pro Trp Trp Gly Glu Ala Val
545 550 555 560
Gly Trp Ala Phe Ala Leu Ser Ser Met Leu Cys Val Pro Leu His Leu
565 570 575
Leu Gly Cys Leu Leu Arg Ala Lys Gly Thr Met Ala Glu Arg Trp Gln
580 585 590
His Leu Thr Gln Pro Ile Trp Gly Leu His His Leu Glu Tyr Arg Ala
595 600 605
Gln Asp Ser Asp Val Arg Gly Leu Thr Thr Leu Thr Pro Val Ser Glu
610 615 620
Ser Ser Lys Val Val Val Val Glu Ser Val Met
625 630 635
<210>141
<211>3453
<212>DNA
<213>牛
<400>141
attgagagta cctcaaactc tccctccagc tcatctcttc aaaagagtcc tttgaacata 60
gttagccagc ctctaactca agaaactgtg ataaacattg atggcatgac ttgtaattcg 120
tgtgtgcagt ctattgaagg tgtcatatca aaaaaggcag gtgtaaaatc catacaagta 180
tcacttgcaa atggcaaagg gactgttgag tatgatcctt tactaacctc tccagaaacc 240
ttgagagaag caatagaaaa catgggattt gatgcttcct tgtcagatac aaatgagcca 300
ttggtagtaa tagctcagcc ctcatcagaa atgccacttt tgacctcaac taatgaattt 360
cacaccaaaa tgatgacacc aattcatgac aaggaggagc caaagacttc atccaagtgt 420
tatatacagg tcactggtat gacttgtgct tcctgtgtag caaacattga acggaattta 480
agacgagaag aaggaatata ttccatactt gtggctctga tggctggcaa ggcagaagta 540
aggtataacc ctgctctcat acaaccccca gtgatagccg agttaatccg agagcttgga 600
tttggatcca ctgtgataga aaatgctgat gaaggagatg gtgttttgga acttgttgtg 660
agaggaatga catgtgcctc ctgtgtccat aaaatagagt ctaccctcac aaaacacaga 720
gggatcttct actgctctgt ggccctggca accaacaaag cacatattaa atatgatcca 780
gaaattattg gtcccagaga tattattcat acaattgaaa gcttgggttt tgaagcttct 840
ttggtcaaga aggaccggtc agcaagccac ctagaccata aacgggaaat aagacagtgg 900
cgacgggcct ttcttgtgag cctatttttc tgtatacctg taatgggact gatgatatat 960
atgatggtta tggaccacca tcttgcaagt cttcaacata atcagaacat gagccaagaa 1020
gaaatgatca acattcattc ttctatgttc ctggagcgcc agatcctgcc aggattgtcc 1080
attatgaatt tgctatcttt tttattgtgt gttcctgtac agttttttgg aggctggcac 1140
ttctatattc aggcctacaa agcactgaag cataaaactg caaatatgga tgtattgatt 1200
gtgctggcaa caaccattgc atttgcttac tctttggtta ttcttctggt tgcaatgtat 1260
gagagagcca aagtgaaccc tgttactttc tttgacacac ctcctatgct atttgtgttt 1320
attgcactag gccggtggct ggaacatgta gcaaagggca aaacatcaga ggctcttgcc 1380
aaactaattt cactacaagc tacagaagca actattgtaa ctcttgactc tgataatatc 1440
ctcttgagtg aagagcaagt ggatgtggaa cttgtacaac gtggagacat tattaaagtg 1500
gttccaggag gcaaatttcc agtggatggg cgtgttattg aaggacattc tatggtagat 1560
gagtccctca tcacaggaga ggcaatgcct gtggccaaga aatctggaag cacagtgatt 1620
gctggttcca ttaaccagaa tgggtcactc cttatccgtg caacccatgt tggagcagac 1680
acaacccttt ctcaaattgt caaacttgta gaggaggcac aaacatcaaa ggctcctatc 1740
cagcagtttg cagacaaact cagtggctac tttgttcctt ttattgttat tgtttccatt 1800
gctacccttt tggtttggat tataattgga tttctgaatt ttgaaatcgt ggaaacctac 1860
tttcccggct acaacagaag tatctcccga acagaaacaa taatacgctt tgctttccaa 1920
gcctctatca cagttctatg cattgcatgc ccctgttccc tgggactggc cactccaact 1980
gctgtgatgg tgggtacagg agtaggtgct caaaatggca tactaatcaa aggtggtgag 2040
ccattggaga tggctcataa ggtaaaggta gtggtatttg ataaaactgg aaccattacc 2100
catggaaccc cagtagtgaa tcaagtaaag gttctagtgg aaagtaatag aatatcacgc 2160
aataagatcc tggctattgt gggaactgct gaaagtaaca gtgaacaccc tctgggagca 2220
gccataacga aatactgcaa gcaggagctg gatactgaaa ccttgggtac ctgcatagat 2280
ttccaggttg tgccaggctg tggcattaac tgtaaagtca ccaatatcga agccttgcta 2340
cacaagaata actggaagat agaggaaaat aatattaaaa atgcatccct ggttcaaata 2400
gatgagagta atgaacagtc atcaacttcg tcttccatga ttattgatgc tcagttctca 2460
aatgctctta atgctcagca gtacaaagtt ctcattggca accgggagtg gatgattaga 2520
aatggtcttg ccattaataa cagtgtaaat gattccatga ctgaacatga gagaagaggt 2580
cggactgctg tactggtagc agttgatgat gagctgtgcg gtttgatagc tattgctgat 2640
acagtgaagc ctgaagcaga actggctgtc catattctga aatctatggg cttagaagta 2700
gttctgatga ctggagacaa cagtaaaaca gctagatcta ttgcttctca ggttggcatt 2760
actaaagtgt ttgctgaagt tctaccttcc cacaaggttg ctaaggtgaa gcaacttcaa 2820
gaggagggga aacgggtagc aatggtagga gatggaatca atgactcccc agctctggcg 2880
atggctaatg ttggaattgc tattggcaca ggcacagatg tagccattga agcagctgat 2940
gtggttttaa taaggaatga tcttctggat gtagtggcaa gtattgattt atcaaggaag 3000
acagtcaaga ggattcggat aaattttgtc tttgctctaa tttataatct gattggaatt 3060
cctatagctg ctggagtttt tatgcccatt ggtttggttt tgcaaccctg gatgggatct 3120
gctgcaatgg ctgcttcatc tgtttcagta gtactttctt cactcttcct taaactttac 3180
aggaaaccaa cttatgagaa ttatgaacta catgctcgaa accaaatggg acagaaaagt 3240
ccttcagaaa taagtgttca tgttggaata gatgatacct caagaaattc tcctaaactg 3300
ggtttgctgg accgaattgt taattacagc agagcctcca taaattcact actgtctgat 3360
aaacgatcac taaacagcgt tggtaccagt gaacctgaca agcactcact cctggtcgga 3420
gactgcaggg aagatgacga cagtgcgttg taa 3453
<210>142
<211>1500
<212>PRT
<213>牛
<400>142
Met Asp Leu Ser Val Ser Val Asn Ser Val Thr Ile Ser Val Glu Gly
1 5 10 15
Met Thr Cys Ser Ser Cys Val Trp Thr Ile Glu Gln Gln Ile Gly Lys
20 25 30
Leu Asn Gly Val His His Ile Lys Val Ser Leu Glu Glu Lys Asn Ala
35 40 45
Thr Val Ile Tyr Asp Pro Lys Leu Gln Thr Pro Lys Thr Leu Gln Glu
50 55 60
Ala Ile Asp Asp Met Gly Phe Asp Ala Ile Leu His Asn Pro Lys Pro
65 70 75 80
Leu Pro Val Leu Thr Glu Thr Val Phe Leu Thr Val Thr Ala Ser Leu
85 90 95
Val Pro Pro Trp Asp His Ile Gln Ser Thr Leu Leu Lys Thr Lys Gly
100 105 110
Val Thr Asp Ile Lys Ile Ser Pro Gln Gln Arg Thr Ala Val Val Thr
115 120 125
Ile Ile Pro Ser Ile Val Asn Ala Asn Gln Ile Val Glu Leu Val Pro
130 135 140
Asp Leu Ser Leu Asp Thr Gly Thr Leu Glu Lys Lys Ser Gly Thr Cys
145 150 155 160
Glu Asp Tyr Ser Met Ala Gln Pro Gly Glu Val Met Leu Lys Met Lys
165 170 175
Val Glu Gly Met Thr Cys His Ser Cys Thr Ser Thr Ile Glu Gly Lys
180 185 190
Ile Gly Lys Leu Gln Gly Val Gln Arg Ile Lys Val Ser Leu Asp Asn
195 200 205
Gln Glu Ala Thr Val Val Tyr Gln Pro His Leu Ile Thr Ala Glu Glu
210 215 220
Ile Lys Lys Gln Ile Glu Val Val Gly Phe Thr Ala Phe Ile Lys Lys
225 230 235 240
Gln Pro Lys Tyr Leu Lys Leu Gly Ala Ile Asp Ile Glu Arg Leu Lys
245 250 255
Asn Thr Pro Val Lys Ser Ser Glu Gly Ser Gln Gln Lys Ser Pro Ser
260 265 270
Tyr Thr Ser Asn Ser Thr Val Ile Phe Thr Ile Asp Gly Met His Cys
275 280 285
Lys Ser Cys Val Ser Asn Ile Glu Ser Ala Leu Ser Thr Leu Gln His
290 295 300
Ile Ser Ser Val Val Val Ser Leu Glu Asn Lys Ser Ala Ile Val Lys
305 310 315 320
Tyr Asn Ala Ser Leu Val Thr Pro Glu Thr Leu Arg Lys Ala Ile Glu
325 330 335
Ala Ile Ser Gln Gly Gln Tyr Arg Val Ser Ser Ala Ser Glu Ile Glu
340 345 350
Ser Thr Ser Asn Ser Pro Ser Ser Ser Ser Leu Gln Lys Ser Pro Leu
355 360 365
Asn Ile Val Ser Gln Pro Leu Thr Gln Glu Thr Val Ile Asn Ile Asp
370 375 380
Gly Met Thr Cys Asn Ser Cys Val Gln Ser Ile Glu Gly Val Ile Ser
385 390 395 400
Lys Lys Ala Gly Val Lys Ser Ile Gln Val Ser Leu Ala Asn Gly Lys
405 410 415
Gly Thr Val Glu Tyr Asp Pro Leu Leu Thr Ser Pro Glu Thr Leu Arg
420 425 430
Glu Ala Ile Glu Asn Met Gly Phe Asp Ala Ser Leu Ser Asp Thr Asn
435 440 445
Glu Pro Leu Val Val Ile Ala Gln Pro Ser Ser Glu Met Pro Leu Leu
450 455 460
Thr Ser Thr Asn Glu Phe His Thr Lys Met Met Thr Pro Ile His Asp
465 470 475 480
Lys Glu Glu Pro Lys Thr Ser Ser Lys Cys Tyr Ile Gln Val Thr Gly
485 490 495
Met Thr Cys Ala Ser Cys Val Ala Asn Ile Glu Arg Asn Leu Arg Arg
500 505 510
Glu Glu Gly Ile Tyr Ser Ile Leu Val Ala Leu Met Ala Gly Lys Ala
515 520 525
Glu Val Arg Tyr Asn Pro Ala Leu Ile Gln Pro Pro Val Ile Ala Glu
530 535 540
Leu Ile Arg Glu Leu Gly Phe Gly Ser Thr Val Ile Glu Asn Ala Asp
545 550 555 560
Glu Gly Asp Gly Val Leu Glu Leu Val Val Arg Gly Met Thr Cys Ala
565 570 575
Ser Cys Val His Lys Ile Glu Ser Thr Leu Thr Lys His Arg Gly Ile
580 585 590
Phe Tyr Cys Ser Val Ala Leu Ala Thr Asn Lys Ala His Ile Lys Tyr
595 600 605
Asp Pro Glu Ile Ile Gly Pro Arg Asp Ile Ile His Thr Ile Glu Ser
610 615 620
Leu Gly Phe Glu Ala Ser Leu Val Lys Lys Asp Arg Ser Ala Ser His
625 630 635 640
Leu Asp His Lys Arg Glu Ile Arg Gln Trp Arg Arg Ala Phe Leu Val
645 650 655
Ser Leu Phe Phe Cys Ile Pro Val Met Gly Leu Met Ile Tyr Met Met
660 665 670
Val Met Asp His His Leu Ala Ser Leu Gln His Asn Gln Asn Met Ser
675 680 685
Gln Glu Glu Met Ile Asn Ile His Ser Ser Met Phe Leu Glu Arg Gln
690 695 700
Ile Leu Pro Gly Leu Ser Ile Met Asn Leu Leu Ser Phe Leu Leu Cys
705 710 715 720
Val Pro Val Gln Phe Phe Gly Gly Trp His Phe Tyr Ile Gln Ala Tyr
725 730 735
Lys Ala Leu Lys His Lys Thr Ala Asn Met Asp Val Leu Ile Val Leu
740 745 750
Ala Thr Thr Ile Ala Phe Ala Tyr Ser Leu Val Ile Leu Leu Val Ala
755 760 765
Met Tyr Glu Arg Ala Lys Val Asn Pro Val Thr Phe Phe Asp Thr Pro
770 775 780
Pro Met Leu Phe Val Phe Ile Ala Leu Gly Arg Trp Leu Glu His Val
785 790 795 800
Ala Lys Gly Lys Thr Ser Glu Ala Leu Ala Lys Leu Ile Ser Leu Gln
805 810 815
Ala Thr Glu Ala Thr Ile Val Thr Leu Asp Ser Asp Asn Ile Leu Leu
820 825 830
Ser Glu Glu Gln Val Asp Val Glu Leu Val Gln Arg Gly Asp Ile Ile
835 840 845
Lys Val Val Pro Gly Gly Lys Phe Pro Val Asp Gly Arg Val Ile Glu
850 855 860
Gly His Ser Met Val Asp Glu Ser Leu Ile Thr Gly Glu Ala Met Pro
865 870 875 880
Val Ala Lys Lys Ser Gly Ser Thr Val Ile Ala Gly Ser Ile Asn Gln
885 890 895
Asn Gly Ser Leu Leu Ile Arg Ala Thr His Val Gly Ala Asp Thr Thr
900 905 910
Leu Ser Gln Ile Val Lys Leu Val Glu Glu Ala Gln Thr Ser Lys Ala
915 920 925
Pro Ile Gln Gln Phe Ala Asp Lys Leu Ser Gly Tyr Phe Val Pro Phe
930 935 940
Ile Val Ile Val Ser Ile Ala Thr Leu Leu Val Trp Ile Ile Ile Gly
945 950 955 960
Phe Leu Asn Phe Glu Ile Val Glu Thr Tyr Phe Pro Gly Tyr Asn Arg
965 970 975
Ser Ile Ser Arg Thr Glu Thr Ile Ile Arg Phe Ala Phe Gln Ala Ser
980 985 990
Ile Thr Val Leu Cys Ile Ala Cys Pro Cys Ser Leu Gly Leu Ala Thr
995 1000 1005
Pro Thr Ala Val Met Val Gly Thr Gly Val Gly Ala Gln Asn Gly Ile
1010 1015 1020
Leu Ile Lys Gly Gly Glu Pro Leu Glu Met Ala His Lys Val Lys Val
1025 1030 1035 1040
Val Val Phe Asp Lys Thr Gly Thr Ile Thr His Gly Thr Pro Val Val
1045 1050 1055
Asn Gln Val Lys Val Leu Val Glu Ser Asn Arg Ile Ser Arg Asn Lys
1060 1065 1070
Ile Leu Ala Ile Val Gly Thr Ala Glu Ser Asn Ser Glu His Pro Leu
1075 1080 1085
Gly Ala Ala Ile Thr Lys Tyr Cys Lys Gln Glu Leu Asp Thr Glu Thr
1090 1095 1100
Leu Gly Thr Cys Ile Asp Phe Gln Val Val Pro Gly Cys Gly Ile Asn
1105 1110 1115 1120
Cys Lys Val Thr Asn Ile Glu Ala Leu Leu His Lys Asn Asn Trp Lys
1125 1130 1135
Ile Glu Glu Asn Asn Ile Lys Asn Ala Ser Leu Val Gln Ile Asp Glu
1140 1145 1150
Ser Asn Glu Gln Ser Ser Thr Ser Ser Ser Met Ile Ile Asp Ala Gln
1155 1160 1165
Phe Ser Asn Ala Leu Asn Ala Gln Gln Tyr Lys Val Leu Ile Gly Asn
1170 1175 1180
Arg Glu Trp Met Ile Arg Asn Gly Leu Ala Ile Asn Asn Ser Val Asn
1185 1190 1195 1200
Asp Ser Met Thr Glu His Glu Arg Arg Gly Arg Thr Ala Val Leu Val
1205 1210 1215
Ala Val Asp Asp Glu Leu Cys Gly Leu Ile Ala Ile Ala Asp Thr Val
1220 1225 1230
Lys Pro Glu Ala Glu Leu Ala Val His Ile Leu Lys Ser Met Gly Leu
1235 1240 1245
Glu Val Val Leu Met Thr Gly Asp Asn Ser Lys Thr Ala Arg Ser Ile
1250 1255 1260
Ala Ser Gln Val Gly Ile Thr Lys Val Phe Ala Glu Val Leu Pro Ser
1265 1270 1275 1280
His Lys Val Ala Lys Val Lys Gln Leu Gln Glu Glu Gly Lys Arg Val
1285 1290 1295
Ala Met Val Gly Asp Gly Ile Asn Asp Ser Pro Ala Leu Ala Met Ala
1300 1305 1310
Asn Val Gly Ile Ala Ile Gly Thr Gly Thr Asp Val Ala Ile Glu Ala
1315 1320 1325
Ala Asp Val Val Leu Ile Arg Asn Asp Leu Leu Asp Val Val Ala Ser
1330 1335 1340
Ile Asp Leu Ser Arg Lys Thr Val Lys Arg Ile Arg Ile Asn Phe Val
1345 1350 1355 1360
Phe Ala Leu Ile Tyr Asn Leu Ile Gly Ile Pro Ile Ala Ala Gly Val
1365 1370 1375
Phe Met Pro Ile Gly Leu Val Leu Gln Pro Trp Met Gly Ser Ala Ala
1380 1385 1390
Met Ala Ala Ser Ser Val Ser Val Val Leu Ser Ser Leu Phe Leu Lys
1395 1400 1405
Leu Tyr Arg Lys Pro Thr Tyr Glu Asn Tyr Glu Leu His Ala Arg Asn
1410 1415 1420
Gln Met Gly Gln Lys Ser Pro Ser Glu Ile Ser Val His Val Gly Ile
1425 1430 1435 1440
Asp Asp Thr Ser Arg Asn Ser Pro Lys Leu Gly Leu Leu Asp Arg Ile
1445 1450 1455
Val Asn Tyr Ser Arg Ala Ser Ile Asn Ser Leu Leu Ser Asp Lys Arg
1460 1465 1470
Ser Leu Asn Ser Val Gly Thr Ser Glu Pro Asp Lys His Ser Leu Leu
1475 1480 1485
Val Gly Asp Cys Arg Glu Asp Asp Asp Ser Ala Leu
1490 1495 1500
<210>143
<211>1335
<212>DNA
<213>牛
<400>143
atgaaattcc cgggctcggt gctggcgtcc gtgttcctgt tcgtggccga gacgtcggcg 60
gcgctgtacc tgagcagcac ctaccgctcg ggcggggacg gcatgtggca ggcgctgacg 120
ctgcttttct cgctgctgcc ctgcgctctg gtgcagctca cgctgctctt cgtgcaccgc 180
gacttcaccc gcgaccggcc gctcgtgctg ctgctgcacc tgctgcagct tgggcccctc 240
ttcaggtgtt ttgaagtctt ctgcatctat tgtcagtcaa accacattga agaaccttat 300
gtcagcatca ccaagaagcg gcagatacca aaaaatggcc actcagagga aattgagaag 360
gaagtgggcc aggcagaggg caagctattc acccaccgat ctgcattcag ccgggcatcg 420
gtgatccagg ctttcctggg ctcagcccca cagctgaccc tgcagctgta cataagtgtc 480
ttgcagcagg atgtcagtat cggacgatgt ctgttcatgg tcctttccct attgtccatt 540
gtgtacggag ccttgcgctg taacatccta gccatcaaga tcaaatacga tgaatatgat 600
gtcaaggtga agcccctggc ctatgtctgt atcttcctct ggaggagctt tgagattgtc 660
acccgagtca ttgtcctggt cctctttacc tctgtcctga aggcctgggt ggtcatagac 720
atactcatca acttcctcgg cttcctcttc tacccctgga tcctcttctg gtgcagtggc 780
tcccccttcc ctgagaactt tgagaaggcc ttcagtcggc tgggcaccac cattgtgctg 840
tgcttcctca ccctcctcta cgccgggatc aacatgttct gctggtcggc ggtgcagctg 900
aaaatcaaca accccgacct catcagcaag tctcagaact ggtaccggct cctggtgtac 960
tacatggtga ggttcatcga gaacgccttc ctcctcctca tgtggtatct ttacaagact 1020
gacatctata tgtatgtgtg tgcacccctg ctgatgctgc agttgctcat tgggtactgc 1080
acggccattc tgttcatggt tgtgttctat cagttcttcc acccttgcaa aaagctcttt 1140
tcccccaatg cttctgaaag ctttcaggag tggctaaagt gtgcctgttg taaccgcagg 1200
cggcgggaat cctgcgagtc tgcagaaaat acagacctaa ggtcacccac agacagagag 1260
gagacccctt ctagcagtaa aataagttcc atgcctagcc agatcttgaa tactgatgag 1320
ctctcttctg cttaa 1335
<210>144
<211>444
<212>PRT
<213>牛
<400>144
Met Lys Phe Pro Gly Ser Val Leu Ala Ser Val Phe Leu Phe Val Ala
1 5 10 15
Glu Thr Ser Ala Ala Leu Tyr Leu Ser Ser Thr Tyr Arg Ser Gly Gly
20 25 30
Asp Gly Met Trp Gln Ala Leu Thr Leu Leu Phe Ser Leu Leu Pro Cys
35 40 45
Ala Leu Val Gln Leu Thr Leu Leu Phe Val His Arg Asp Phe Thr Arg
50 55 60
Asp Arg Pro Leu Val Leu Leu Leu His Leu Leu Gln Leu Gly Pro Leu
65 70 75 80
Phe Arg Cys Phe Glu Val Phe Cys Ile Tyr Cys Gln Ser Asn His Ile
85 90 95
Glu Glu Pro Tyr Val Ser Ile Thr Lys Lys Arg Gln Ile Pro Lys Asn
100 105 110
Gly His Ser Glu Glu Ile Glu Lys Glu Val Gly Gln Ala Glu Gly Lys
115 120 125
Leu Phe Thr His Arg Ser Ala Phe Ser Arg Ala Ser Val Ile Gln Ala
130 135 140
Phe Leu Gly Ser Ala Pro Gln Leu Thr Leu Gln Leu Tyr Ile Ser Val
145 150 155 160
Leu Gln Gln Asp Val Ser Ile Gly Arg Cys Leu Phe Met Val Leu Ser
165 170 175
Leu Leu Ser Ile Val Tyr Gly Ala Leu Arg Cys Asn Ile Leu Ala Ile
180 185 190
Lys Ile Lys Tyr Asp Glu Tyr Asp Val Lys Val Lys Pro Leu Ala Tyr
195 200 205
Val Cys Ile Phe Leu Trp Arg Ser Phe Glu Ile Val Thr Arg Val Ile
210 215 220
Val Leu Val Leu Phe Thr Ser Val Leu Lys Ala Trp Val Val Ile Asp
225 230 235 240
Ile Leu Ile Asn Phe Leu Gly Phe Leu Phe Tyr Pro Trp Ile Leu Phe
245 250 255
Trp Cys Ser Gly Ser Pro Phe Pro Glu Asn Phe Glu Lys Ala Phe Ser
260 265 270
Arg Leu Gly Thr Thr Ile Val Leu Cys Phe Leu Thr Leu Leu Tyr Ala
275 280 285
Gly Ile Asn Met Phe Cys Trp Ser Ala Val Gln Leu Lys Ile Asn Asn
290 295 300
Pro Asp Leu Ile Ser Lys Ser Gln Asn Trp Tyr Arg Leu Leu Val Tyr
305 310 315 320
Tyr Met Val Arg Phe Ile Glu Asn Ala Phe Leu Leu Leu Met Trp Tyr
325 330 335
Leu Tyr Lys Thr Asp Ile Tyr Met Tyr Val Cys Ala Pro Leu Leu Met
340 345 350
Leu Gln Leu Leu Ile Gly Tyr Cys Thr Ala Ile Leu Phe Met Val Val
355 360 365
Phe Tyr Gln Phe Phe His Pro Cys Lys Lys Leu Phe Ser Pro Asn Ala
370 375 380
Ser Glu Ser Phe Gln Glu Trp Leu Lys Cys Ala Cys Cys Asn Arg Arg
385 390 395 400
Arg Arg Glu Ser Cys Glu Ser Ala Glu Asn Thr Asp Leu Arg Ser Pro
405 410 415
Thr Asp Arg Glu Glu Thr Pro Ser Ser Ser Lys Ile Ser Ser Met Pro
420 425 430
Ser Gln Ile Leu Asn Thr Asp Glu Leu Ser Ser Ala
435 440
<210>145
<211>3491
<212>DNA
<213>牛
<400>145
atcacagggg ttggtacaag tagtgtgata atttgcagtg ttctctctgt gacttacctg 60
ctattgtgtt agcaaatttc tgggtgtcgg tatgcagagg gtcccacctt cctctcctgc 120
ctctgagtgt gctggagaag agaagcgagt tggtacgcgc acagtatttg ttggcaatca 180
tccagtttca gaaactgaag catacattgc acaaaaattt tgtgataata gaataatctc 240
atctaagtat acactttgga atttcctccc aaagaatctg tttgaacagt ttagaagaat 300
tgcaaatttt tattttctta taatttttct tatacaggta acagtagaca caccaactag 360
cccaattacc agtggacttc cacttttctt cgttataact gttacagcca tcaagcaggg 420
atatgaggat tggctgaggc acagggccga caatgaagtc aataaaagca ctgtttacat 480
tattgaaaat gcaaagcgag tgaaaaaaga gagtgaaaaa atcaaggtcg gtgatatagt 540
agaagtacag gcagatgaaa cctttccctg tgatcttatt cttctgtcat cctgcacagt 600
tgatggaacc tgttatgtta ccacagccag tcttgatggg gaatcgaatt gcaagacaca 660
ttatgcggta cgtgatacca ttgaactgcg tacagtcgaa tccattgata acctcagagc 720
agcaattgaa tgtgaacagc ctcaacctga cctctacaag tttgttggcc gaatcaatat 780
ctatagtaat agtattgaag ctgttgccag gtctttggga cctgaaaatc tcttgttgaa 840
aggagctaca ctaaaaaata ccaagaagat atatggagtt gctgtttaca ctggaatgga 900
aaccaaaatg gcattgaact aceaagggaa atctcagaaa cgttctgctg ttgaaaaatc 960
cattaatgct ttcctgattg tgtatttatt tatcttactg aceaaagctg caatatgcac 1020
tactctaaag tatgtttggc aaagtacccc acataatgat gaaccttggt ataaccaaaa 1080
gacccagaaa gaacgggaaa cttggaaggt tttaaaaatg ttcactgact tcctgtcatt 1140
tatggttctg ttcaacttta tcattcctgt ctccatgtat gtcacagtag aaatgcaaaa 1200
attcttgggc tccttcttca tttcatggga taacgacttc tatgatgaag aaattaatga 1260
aggagccctg gtaaacacat cagaccttaa tgaagaactt ggtcaggtgg attatgtatt 1320
tactgataag actggaacac ttactgaaaa caccatggaa ttcattgaat gctgcataga 1380
tgggcataag tataaaggtg tagctcagga gactgatgga ctctctcaaa ctgatggacc 1440
cttaccatat ttggacagag ctgataagaa tcgagaagag ctctttctgc gtgccttgtg 1500
tttatgtcac actgtagaag ttaaaccaaa tgatactgtt gatggagtta cagagtcatc 1560
tgaattaacc tatatgtcat cttcaccaga tgaaatagct ttggtcaaag gagctaaaaa 1620
gtatggattc acatttgtag gtgttcagaa tggctatatg agagtagaga accaaagaaa 1680
agaaatagaa gagtatgaac ttcttcacac cttaaacttt gatgctgtcc gccgtcgtat 1740
gagtgtaatt gtgaagactc aaacaggaga tatacttctc ttttgtaaag gagccgactc 1800
agcagttttc cccagggtac aaaatcatga aatcgactta attaaagtcc atgtggaaca 1860
taatgcgatg gaggggtatc ggacactttg tatagccttc aaagaaattg ctccagatga 1920
ttatgaaaga gttaacagac agctcataga ggcaaaaatg gccttacaag acagagaaga 1980
aaaaatggaa aaggttttcg atgagattga gacagacatg catttaattg gagccactgc 2040
agtggaagac aagctacaag atcaagccgc tgagaccatt gaagccctgc atgccgcagg 2100
tctgaaagtc tgggtgctta ctggcgacaa gatggagact gcaaaatcca cctgctatgc 2160
ctgccgcctt ttccaaacca acaccgagct cttggaactg accaccaaga caattgaaga 2220
aagcgaaagg aaagaggatc gattacatga gttgttgact gaatatcgta agaagctgct 2280
gcatgaattt cctaaaagta ctagaagcct taaaaaagcg tggacagaac atcaggaata 2340
cggattaatc attgatggct ccactctgtc tcttatatta aactctagtc aagactctgg 2400
ttctaacaat tacaaaagca ttttcctaca gatctgcatg aagtgcacag cagtgctctg 2460
ctgtcggatg gccccgttac agaaagctca gattgtaaga atggtgaaga atttaaaagg 2520
cagcccaatc acactgtcga taggtgatgg tgccaatgat gttagcatga tcttggaatc 2580
ccatgtgggc ataggtatta aaggcaaaga aggtcgccaa gcatccagga atagcgatta 2640
tgcggtccca aaatttaaac atttaaagaa actgctgttg gctcatggac atctatatta 2700
tgtgagaatt gcacaccttg tccagtattt cttctataag aacctttgtt tcattttgcc 2760
acagtttttg taccagttct tctgtggatt ctcacagcag ccactgtatg atgctgctta 2820
ccttacaatg tacaatatct gcttcacatc cttgcccatc ctggcctaca gtctactgga 2880
acagcacatc aatattgaca cattgacctc agatccccga ttgtacatga aaatatctgg 2940
aaacgccatg ctacagttgg gcccattcct atactggaca tttctggctg catttgaagg 3000
aaccgtgttt ttctttggga cttactttct ttttcagact acatccttag atgaaaatgg 3060
aaaggtatat ggaaattgga catttggaac cattattttt acaatcttgg tattcaccgt 3120
aactctgaag ctcgccttgg atactcgttt ctggacatgg atcaaccacc ttgtgatttg 3180
gggttcttta gcattttatg tatttttctc attcttctgg ggaggaatta tatggccatt 3240
cttgaaacaa cagagaatgt attttgtatt tgctcaaatg ctgtcatctg tatccgtatg 3300
gttgaccata attcttctaa tatttgtcag cctttccccc gagatgctca ggattgtatt 3360
aaggagtgta agaagaagaa gtaccaggag caatctaagc tgtaaaaagg catctgactc 3420
attatccacc agaccttcag tcagacctct tcttttacga acattctcag atgaatctaa 3480
tatattttaa c 3491
<210>146
<211>1132
<212>PRT
<213>牛
<400>146
Met Gln Arg Val Pro Pro Ser Ser Pro Ala Ser Glu Cys Ala Gly Glu
1 5 10 15
Glu Lys Arg Val Gly Thr Arg Thr Val Phe Val Gly Asn His Pro Val
20 25 30
Ser Glu Thr Glu Ala Tyr Ile Ala Gln Lys Phe Cys Asp Asn Arg Ile
35 40 45
Ile Ser Ser Lys Tyr Thr Leu Trp Asn Phe Leu Pro Lys Asn Leu Phe
50 55 60
Glu Gln Phe Arg Arg Ile Ala Asn Phe Tyr Phe Leu Ile Ile Phe Leu
65 70 75 80
Ile Gln Val Thr Val Asp Thr Pro Thr Ser Pro Ile Thr Ser Gly Leu
85 90 95
Pro Leu Phe Phe Val Ile Thr Val Thr Ala Ile Lys Gln Gly Tyr Glu
100 105 110
Asp Trp Leu Arg His Arg Ala Asp Asn Glu Val Asn Lys Ser Thr Val
115 120 125
Tyr Ile Ile Glu Asn Ala Lys Arg Val Lys Lys Glu Ser Glu Lys Ile
130 135 140
Lys Val Gly Asp Ile Val Glu Val Gln Ala Asp Glu Thr Phe Pro Cys
145 150 155 160
Asp Leu Ile Leu Leu Ser Ser Cys Thr Val Asp Gly Thr Cys Tyr Val
165 170 175
Thr Thr Ala Ser Leu Asp Gly Glu Ser Asn Cys Lys Thr His Tyr Ala
180 185 190
Val Arg Asp Thr Ile Glu Leu Arg Thr Val Glu Ser Ile Asp Asn Leu
195 200 205
Arg Ala Ala Ile Glu Cys Glu Gln Pro Gln Pro Asp Leu Tyr Lys Phe
210 215 220
Val Gly Arg Ile Asn Ile Tyr Ser Asn Ser Ile Glu Ala Val Ala Arg
225 230 235 240
Ser Leu Gly Pro Glu Asn Leu Leu Leu Lys Gly Ala Thr Leu Lys Asn
245 250 255
Thr Lys Lys Ile Tyr Gly Val Ala Val Tyr Thr Gly Met Glu Thr Lys
260 265 270
Met Ala Leu Asn Tyr Gln Gly Lys Ser Gln Lys Arg Ser Ala Val Glu
275 280 285
Lys Ser Ile Asn Ala Phe Leu Ile Val Tyr Leu Phe Ile Leu Leu Thr
290 295 300
Lys Ala Ala Ile Cys Thr Thr Leu Lys Tyr Val Trp Gln Ser Thr Pro
305 310 315 320
His Asn Asp Glu Pro Trp Tyr Asn Gln Lys Thr Gln Lys Glu Arg Glu
325 330 335
Thr Trp Lys Val Leu Lys Met Phe Thr Asp Phe Leu Ser Phe Met Val
340 345 350
Leu Phe Asn Phe Ile Ile Pro Val Ser Met Tyr Val Thr Val Glu Met
355 360 365
Gln Lys Phe Leu Gly Ser Phe Phe Ile Ser Trp Asp Asn Asp Phe Tyr
370 375 380
Asp Glu Glu Ile Asn Glu Gly Ala Leu Val Asn Thr Ser Asp Leu Asn
385 390 395 400
Glu Glu Leu Gly Gln Val Asp Tyr Val Phe Thr Asp Lys Thr Gly Thr
405 410 415
Leu Thr Glu Asn Thr Met Glu Phe Ile Glu Cys Cys Ile Asp Gly His
420 425 430
Lys Tyr Lys Gly Val Ala Gln Glu Thr Asp Gly Leu Ser Gln Thr Asp
435 440 445
Gly Pro Leu Pro Tyr Leu Asp Arg Ala Asp Lys Asn Arg Glu Glu Leu
450 455 460
Phe Leu Arg Ala Leu Cys Leu Cys His Thr Val Glu Val Lys Pro Asn
465 470 475 480
Asp Thr Val Asp Gly Val Thr Glu Ser Ser Glu Leu Thr Tyr Met Ser
485 490 495
Ser Ser Pro Asp Glu Ile Ala Leu Val Lys Gly Ala Lys Lys Tyr Gly
500 505 510
Phe Thr Phe Val Gly Val Gln Asn Gly Tyr Met Arg Val Glu Asn Gln
515 520 525
Arg Lys Glu Ile Glu Glu Tyr Glu Leu Leu His Thr Leu Asn Phe Asp
530 535 540
Ala Val Arg Arg Arg Met Ser Val Ile Val Lys Thr Gln Thr Gly Asp
545 550 555 560
Ile Leu Leu Phe Cys Lys Gly Ala Asp Ser Ala Val Phe Pro Arg Val
565 570 575
Gln Asn His Glu Ile Asp Leu Ile Lys Val His Val Glu His Asn Ala
580 585 590
Met Glu Gly Tyr Arg Thr Leu Cys Ile Ala Phe Lys Glu Ile Ala Pro
595 600 605
Asp Asp Tyr Glu Arg Val Asn Arg Gln Leu Ile Glu Ala Lys Met Ala
610 615 620
Leu Gln Asp Arg Glu Glu Lys Met Glu Lys Val Phe Asp Glu Ile Glu
625 630 635 640
Thr Asp Met His Leu Ile Gly Ala Thr Ala Val Glu Asp Lys Leu Gln
645 650 655
Asp Gln Ala Ala Glu Thr Ile Glu Ala Leu His Ala Ala Gly Leu Lys
660 665 670
Val Trp Val Leu Thr Gly Asp Lys Met Glu Thr Ala Lys Ser Thr Cys
675 680 685
Tyr Ala Cys Arg Leu Phe Gln Thr Asn Thr Glu Leu Leu Glu Leu Thr
690 695 700
Thr Lys Thr Ile Glu Glu Ser Glu Arg Lys Glu Asp Arg Leu His Glu
705 710 715 720
Leu Leu Thr Glu Tyr Arg Lys Lys Leu Leu His Glu Phe Pro Lys Ser
725 730 735
Thr Arg Ser Leu Lys Lys Ala Trp Thr Glu His Gln Glu Tyr Gly Leu
740 745 750
Ile Ile Asp Gly Ser Thr Leu Ser Leu Ile Leu Asn Ser Ser Gln Asp
755 760 765
Ser Gly Ser Asn Asn Tyr Lys Ser Ile Phe Leu Gln Ile Cys Met Lys
770 775 780
Cys Thr Ala Val Leu Cys Cys Arg Met Ala Pro Leu Gln Lys Ala Gln
785 790 795 800
Ile Val Arg Met Val Lys Asn Leu Lys Gly Ser Pro Ile Thr Leu Ser
805 810 815
Ile Gly Asp Gly Ala Asn Asp Val Ser Met Ile Leu Glu Ser His Val
820 825 830
Gly Ile Gly Ile Lys Gly Lys Glu Gly Arg Gln Ala Ser Arg Asn Ser
835 840 845
Asp Tyr Ala Val Pro Lys Phe Lys His Leu Lys Lys Leu Leu Leu Ala
850 855 860
His Gly His Leu Tyr Tyr Val Arg Ile Ala His Leu Val Gln Tyr Phe
865 870 875 880
Phe Tyr Lys Asn Leu Cys Phe Ile Leu Pro Gln Phe Leu Tyr Gln Phe
885 890 895
Phe Cys Gly Phe Ser Gln Gln Pro Leu Tyr Asp Ala Ala Tyr Leu Thr
900 905 910
Met Tyr Asn Ile Cys Phe Thr Ser Leu Pro Ile Leu Ala Tyr Ser Leu
915 920 925
Leu Glu Gln His Ile Asn Ile Asp Thr Leu Thr Ser Asp Pro Arg Leu
930 935 940
Tyr Met Lys Ile Ser Gly Asn Ala Met Leu Gln Leu Gly Pro Phe Leu
945 950 955 960
Tyr Trp Thr Phe Leu Ala Ala Phe Glu Gly Thr Val Phe Phe Phe Gly
965 970 975
Thr Tyr Phe Leu Phe Gln Thr Thr Ser Leu Asp Glu Asn Gly Lys Val
980 985 990
Tyr Gly Asn Trp Thr Phe Gly Thr Ile Ile Phe Thr Ile Leu Val Phe
995 1000 1005
Thr Val Thr Leu Lys Leu Ala Leu Asp Thr Arg Phe Trp Thr Trp Ile
1010 1015 1020
Asn His Leu Val Ile Trp Gly Ser Leu Ala Phe Tyr Val Phe Phe Ser
1025 1030 1035 1040
Phe Phe Trp Gly Gly Ile Ile Trp Pro Phe Leu Lys Gln Gln Arg Met
1045 1050 1055
Tyr Phe Val Phe Ala Gln Met Leu Ser Ser Val Ser Val Trp Leu Thr
1060 1065 1070
Ile Ile Leu Leu Ile Phe Val Ser Leu Ser Pro Glu Met Leu Arg Ile
1075 1080 1085
Val Leu Arg Ser Val Arg Arg Arg Ser Thr Arg Ser Asn Leu Ser Cys
1090 1095 1100
Lys Lys Ala Ser Asp Ser Leu Ser Thr Arg Pro Ser Val Arg Pro Leu
1105 1110 1115 1120
Leu Leu Arg Thr Phe Ser Asp Glu Ser Asn Ile Phe
1125 1130
<210>147
<211>2078
<212>DNA
<213>牛
<400>147
ggagaaggcg gagaccgtcc cagcgggagg cgacggcagg gcgggctctg ggagtcgggg 60
cgagcccgag ctcgtcacec cctcgtgctg cgccggtcgt agcgtcctgc tggccagttc 120
cgcgtcgccc tgcgctgctg cagccgccgc ggaactatgg ctgtgctcgt cgtgttcctg 180
tccttcttgg tggcggatgt ctttgggaac gaattcagta tattaagatc accagggtct 240
gttgttttcc ggaatggaaa ttggcctatt ccaggagagc gaatcccaga cgtggctgca 300
ttgtccatgg gcttctctgt gaaagaggat ctttcttggc cgggccttgc agtaggtaac 360
ctattccacc gtcctcgggc tactgttatg gtgatggtga aaggagtgga caagcttgct 420
ctacccccag gcagtgtcat ttcgtaccct ttggagaatg cagttccttt tagtcttgac 480
agcgtggcaa attccattca ctccttattt tctgaagaaa ctcctgtggt tttgcagttg 540
gctcccagtg aggaaagagt gtacatggtg gggaaggcaa actcagtttt tgaagatctc 600
tcagtaacgc tcagacagct ccgcaatcga ctgtttcaag aaaactctgt tctcacttca 660
cttcccctca attctctgag taggaacaat gaagttgatc tcctttttct ttctgaactg 720
caagtgctac gtgatatttc aagtttgttg tctcgacata agcatctagc caaggatcat 780
tctcctgatt tatactcact ggagctagca ggcctggatg aaattgggaa acactatggg 840
gaagactctg aacaatttag agatgcctct aagatcctta ttgatgctct gcaaaagttt 900
gcagatgaca tgtacaatct ctatggtggg aatgcagtgg tagagttagt gactgtcaga 960
tcattcgaca catcccttgt gaggaagacg aggaatatcc ttgagacaaa acaagtgaag 1020
gacccctcaa ctacctataa ccttgcatat aaatataatt ttgaatatcc cgtggttttc 1080
aacctggtac tttggataat gatcggcttg gccttgactc tgattgtcac ctgttacaat 1140
atttggaaca tggatcctgg atatgatagc atcatttata ggatgacaaa ccagaagatt 1200
cgaatggatt gaactttcct tatgacaaac ttggaaagaa agagggtttg aaaattggct 1260
ctttcattaa aataaatctt ttagtgtagt ttaaactaga tagtacactt taaatttata 1320
aaaaaaacaa acaaacagat tttgttctct tttgtgtgtg cctgtgatgt tcttttagag 1380
tgagttatat agtattgatg tgagttgact tgtgtgatat agattccata atatgcttaa 1440
atacgatgat ataaccattt aatataattt cattceatct actatttgga aatatgcact 1500
gtaataaatg taaaacattt agaatagttt gtgttattta tgtcgggaaa atgcactgaa 1560
tttgaaatgt ttaacttcct tacacaggac aggttaaaag tgacatttgg gctgttatat 1620
actatgaacc atttgtaaat gtcttaatgt aaatatctct gaaacaagaa aaggttttta 1680
acttcaagca gctattaagt atgaatgtgc ttccacagtc attcacattt tcaattgcat 1740
ctgattgaca gatgatagct gtttttttta atctcttctg aaattttggt gatctgaatg 1800
gtcaagtgtg gatattaaac atactacatt aatgtaagaa ggaactagct ttgtggcgtt 1860
aagacacttg taatcatata cacaaaaaca tttgggggac atcttggggc atgatttcag 1920
tcatttttcc ccttgtgtaa gttactctgg tttacggtac aaaattgttc tatatagaat 1980
gttaagttgt taagtggaag tagatactcc ctacttttta tgtgaaagtg gaccaatgtc 2040
tataaagagt gacaaataaa gttaataatg attcaaaa 2078
<210>148
<211>351
<212>PRT
<213>牛
<400>148
Met Ala Val Leu Val Val Phe Leu Ser Phe Leu Val Ala Asp Val Phe
1 5 10 15
Gly Asn Glu Phe Ser Ile Leu Arg Ser Pro Gly Ser Val Val Phe Arg
20 25 30
Asn Gly Asn Trp Pro Ile Pro Gly Glu Arg Ile Pro Asp Val Ala Ala
35 40 45
Leu Ser Met Gly Phe Ser Val Lys Glu Asp Leu Ser Trp Pro Gly Leu
50 55 60
Ala Val Gly Asn Leu Phe His Arg Pro Arg Ala Thr Val Met Val Met
65 70 75 80
Val Lys Gly Val Asp Lys Leu Ala Leu Pro Pro Gly Ser Val Ile Ser
85 90 95
Tyr Pro Leu Glu Asn Ala Val Pro Phe Ser Leu Asp Ser Val Ala Asn
100 105 110
Ser Ile His Ser Leu Phe Ser Glu Glu Thr Pro Val Val Leu Gln Leu
115 120 125
Ala Pro Ser Glu Glu Arg Val Tyr Met Val Gly Lys Ala Asn Ser Val
130 135 140
Phe Glu Asp Leu Ser Val Thr Leu Arg Gln Leu Arg Asn Arg Leu Phe
145 150 155 160
Gln Glu Asn Ser Val Leu Thr Ser Leu Pro Leu Asn Ser Leu Ser Arg
165 170 175
Asn Asn Glu Val Asp Leu Leu Phe Leu Ser Glu Leu Gln Val Leu Arg
180 185 190
Asp Ile Ser Ser Leu Leu Ser Arg His Lys His Leu Ala Lys Asp His
195 200 205
Ser Pro Asp Leu Tyr Ser Leu Glu Leu Ala Gly Leu Asp Glu Ile Gly
210 215 220
Lys His Tyr Gly Glu Asp Ser Glu Gln Phe Arg Asp Ala Ser Lys Ile
225 230 235 240
Leu Ile Asp Ala Leu Gln Lys Phe Ala Asp Asp Met Tyr Asn Leu Tyr
245 250 255
Gly Gly Asn Ala Val Val Glu Leu Val Thr Val Arg Ser Phe Asp Thr
260 265 270
Ser Leu Val Arg Lys Thr Arg Asn Ile Leu Glu Thr Lys Gln Val Lys
275 280 285
Asp Pro Ser Thr Thr Tyr Asn Leu Ala Tyr Lys Tyr Asn Phe Glu Tyr
290 295 300
Pro Val Val Phe Asn Leu Val Leu Trp Ile Met Ile Gly Leu Ala Leu
305 310 315 320
Thr Leu Ile Val Thr Cys Tyr Asn Ile Trp Asn Met Asp Pro Gly Tyr
325 330 335
Asp Ser Ile Ile Tyr Arg Met Thr Asn Gln Lys Ile Arg Met Asp
340 345 350
<210>149
<211>654
<212>DNA
<213>牛
<400>149
tacacatcta ccatgtcctt gctcatcaac agcgccaatt gccaaatagt aggttttgca 60
gtagccacta ttggatggat cctcggcacc actgccatgg gcttcgtgga gtggcgagta 120
tggtatctag acaacgcctc acaattctct ggtctggcct gcatgggaat gtggagagtc 180
tgtgtcttcc gtcaaaccaa catcaccaca gctacctcat gtcacagtta cagctaccat 240
gatacttacc tacctcttga tatccgtgtt tctcaacacc tcttactgat ggccagcatt 300
ctaggactct tggggaaagc ctctgttact tttgcactta aaaatgtgtc catgggaatt 360
cttgagaata ctactaccta caaagcattt gtcatttcag gaattctcca catagctgct 420
ggtatctgta tctcagttgc tgtcatctgg aattaccact ctgtgatgac tgaagagggc 480
attgtcttcc caccatcttt caatataccc ttcaagccat atgctcagaa aattggcaac 540
actgttatag tggcatgtct agctgccttt gcgctgttct taggtgggtg gttttttctc 600
tcttacaaat tacccctgga taaccaggtg catcctgaag tatcaggaat gtag 654
<210>150
<211>213
<212>PRT
<213>牛
<400>150
Met Ser Leu Leu Ile Asn Ser Ala Asn Cys Gln Ile Val Gly Phe Ala
1 5 10 15
Val Ala Thr Ile Gly Trp Ile Leu Gly Thr Thr Ala Met Gly Phe Val
20 25 30
Glu Trp Arg Val Trp Tyr Leu Asp Asn Ala Ser Gln Phe Ser Gly Leu
35 40 45
Ala Cys Met Gly Met Trp Arg Val Cys Val Phe Arg Gln Thr Asn Ile
50 55 60
Thr Thr Ala Thr Ser Cys His Ser Tyr Ser Tyr His Asp Thr Tyr Leu
65 70 75 80
Pro Leu Asp Ile Arg Val Ser Gln His Leu Leu Leu Met Ala Ser Ile
85 90 95
Leu Gly Leu Leu Gly Lys Ala Ser Val Thr Phe Ala Leu Lys Asn Val
100 105 110
Ser Met Gly Ile Leu Glu Asn Thr Thr Thr Tyr Lys Ala Phe Val Ile
115 120 125
Ser Gly Ile Leu His Ile Ala Ala Gly Ile Cys Ile Ser Val Ala Val
130 135 140
Ile Trp Asn Tyr His Ser Val Met Thr Glu Glu Gly Ile Val Phe Pro
145 150 155 160
Pro Ser Phe Asn Ile Pro Phe Lys Pro Tyr Ala Gln Lys Ile Gly Asn
165 170 175
Thr Val Ile Val Ala Cys Leu Ala Ala Phe Ala Leu Phe Leu Gly Gly
180 185 190
Trp Phe Phe Leu Ser Tyr Lys Leu Pro Leu Asp Asn Gln Val His Pro
195 200 205
Glu Val Ser Gly Met
210
<210>151
<211>1083
<212>DNA
<213>牛
<400>151
ctcaccatgc acaccaccct ccctgaatca acttcagaaa acttcgagta ttatgacctt 60
gcagaagcct gtgatatggg ggacatcgtg gccttgggaa ctgtcttcgt ggtcatactc 120
tactccctcg tctttgcctt tggcctggtg ggaaatttgc tggtggtgtt tgccctcatc 180
aacagccaga ggtccaaaag tattactgac atttacctcc tgaacctggc cttgtctgat 240
ctgctctttg tagccacctt gcccttctgg actcactatg tgataaatga gcaaggcctt 300
caccacgcca cgtgcaaact catcactgcc ttcttcttca ttggattttt tggaggcata 360
ttcttcatca ccgttatcag cgtcgacagg ttcctggcca ttgtgctggc tgccaactcc 420
atgagcaaca ggaccgtgca gcatggtgtc accaccagcc tcggcgtctg ggcagctgcc 480
atcttggtgg ccacaccgca gttcatgttc accagagaga aagagaacga atgctttggc 540
gactaccctg agatcctgca ggaaatctgg cctgtgatcc tcaacacgga aataaatttt 600
cttggcttcc tgctccccct gctcattatg agttactgtt acttcagaat catgcagaca 660
ttgttttcct gcaagaacca caagaaagct aaagccatca ggctgatctt tctggtggtc 720
gtcgtttttt tcctcttctg gacaccctat aatgtcatga ttttcttaca gacactcaat 780
ctctatgact tctttcccaa atgtgatgtg aagagagatc tgaagttggc catcagtgtg 840
acagagacaa ttgcatttag ccactgttgc ctcaatcccc ttatctatgc atttgctgga 900
gagaagttca gacgatacct ttaccgtctg tacaggaaat gcctggctgt cctgtgttgc 960
catcctgacc acctcagttt ctcttcatct ctgtctgaat cacaaaggag caggcgggaa 1020
agtgttctga gcagcaattt tactcattac accagcgatg gagatgcgtc catccttctc 1080
tga 1083
<210>152
<211>358
<212>PRT
<213>牛
<400>152
Met His Thr Thr Leu Pro Glu Ser Thr Ser Glu Asn Phe Glu Tyr Tyr
1 5 10 15
Asp Leu Ala Glu Ala Cys Asp Met Gly Asp Ile Val Ala Leu Gly Thr
20 25 30
Val Phe Val Val Ile Leu Tyr Ser Leu Val Phe Ala Phe Gly Leu Val
35 40 45
Gly Asn Leu Leu Val Val Phe Ala Leu Ile Asn Ser Gln Arg Ser Lys
50 55 60
Ser Ile Thr Asp Ile Tyr Leu Leu Asn Leu Ala Leu Ser Asp Leu Leu
65 70 75 80
Phe Val Ala Thr Leu Pro Phe Trp Thr His Tyr Val Ile Asn Glu Gln
85 90 95
Gly Leu His His Ala Thr Cys Lys Leu Ile Thr Ala Phe Phe Phe Ile
100 105 110
Gly Phe Phe Gly Gly Ile Phe Phe Ile Thr Val Ile Ser Val Asp Arg
115 120 125
Phe Leu Ala Ile Val Leu Ala Ala Asn Ser Met Ser Asn Arg Thr Val
130 135 140
Gln His Gly Val Thr Thr Ser Leu Gly Val Trp Ala Ala Ala Ile Leu
145 150 155 160
Val Ala Thr Pro Gln Phe Met Phe Thr Arg Glu Lys Glu Asn Glu Cys
165 170 175
Phe Gly Asp Tyr Pro Glu Ile Leu Gln Glu Ile Trp Pro Val Ile Leu
180 185 190
Asn Thr Glu Ile Asn Phe Leu Gly Phe Leu Leu Pro Leu Leu Ile Met
195 200 205
Ser Tyr Cys Tyr Phe Arg Ile Met Gln Thr Leu Phe Ser Cys Lys Asn
210 215 220
His Lys Lys Ala Lys Ala Ile Arg Leu Ile Phe Leu Val Val Val Val
225 230 235 240
Phe Phe Leu Phe Trp Thr Pro Tyr Asn Val Met Ile Phe Leu Gln Thr
245 250 255
Leu Asn Leu Tyr Asp Phe Phe Pro Lys Cys Asp Val Lys Arg Asp Leu
260 265 270
Lys Leu Ala Ile Ser Val Thr Glu Thr Ile Ala Phe Ser His Cys Cys
275 280 285
Leu Asn Pro Leu Ile Tyr Ala Phe Ala Gly Glu Lys Phe Arg Arg Tyr
290 295 300
Leu Tyr Arg Leu Tyr Arg Lys Cys Leu Ala Val Leu Cys Cys His Pro
305 310 315 320
Asp His Leu Ser Phe Ser Ser Ser Leu Ser Glu Ser Gln Arg Ser Arg
325 330 335
Arg Glu Ser Val Leu Ser Ser Asn Phe Thr His Tyr Thr Ser Asp Gly
340 345 350
Asp Ala Ser Ile Leu Leu
355
<210>153
<211>480
<212>DNA
<213>牛
<400>153
atgtggtccc tcaaatcgtt cttgtgctta tccattgttg tttcctgtgt ctacgcctta 60
atgtttactt ctctgacaga gaaagttaaa gaaatccagt ggaaggtgct ctgcagagga 120
cactttttaa ttcagcagaa tctacaagag caagcccaag actggcttga gatcacgttg 180
ctctggcttt tcttcattgt gctgatgtac gtgacagtga agttggcagg agagaatggc 240
gagagtagag tgcagacttc tcatgccctt cagggccgtt catttggctt tcttggaaat 300
aaaaaggtaa agacttcctc taaagaagtc tacatgttcc ataccttaac cctgctcgag 360
atggaccttg tgaaatttgt gtgcagggtg cagaatctga aactcgccac atcaaccagc 420
ggtaacatca accccctcaa tgtcaaggtt cctgcagatg tatcagttca ggggcaatga 480
<210>154
<211>159
<212>PRT
<213>牛
<400>154
Met Trp Ser Leu Lys Ser Phe Leu Cys Leu Ser Ile Val Val Ser Cys
1 5 10 15
Val Tyr Ala Leu Met Phe Thr Ser Leu Thr Glu Lys Val Lys Glu Ile
20 25 30
Gln Trp Lys Val Leu Cys Arg Gly His Phe Leu Ile Gln Gln Asn Leu
35 40 45
Gln Glu Gln Ala Gln Asp Trp Leu Glu Ile Thr Leu Leu Trp Leu Phe
50 55 60
Phe Ile Val Leu Met Tyr Val Thr Val Lys Leu Ala Gly Glu Asn Gly
65 70 75 80
Glu Ser Arg Val Gln Thr Ser His Ala Leu Gln Gly Arg Ser Phe Gly
85 90 95
Phe Leu Gly Asn Lys Lys Val Lys Thr Ser Ser Lys Glu Val Tyr Met
100 105 110
Phe His Thr Leu Thr Leu Leu Glu Met Asp Leu Val Lys Phe Val Cys
115 120 125
Arg Val Gln Asn Leu Lys Leu Ala Thr Ser Thr Ser Gly Asn Ile Asn
130 135 140
Pro Leu Asn Val Lys Val Pro Ala Asp Val Ser Val Gln Gly Gln
145 150 155
<210>155
<211>555
<212>DNA
<213>牛
<400>155
cagctcacga tgcgctctgt aatatggtta tttttttggc ctacgcttat ctcgtttgtc 60
tttgcctatg tgttttatgt tctgagagat gaagccgaag aactgccgtg gatggtgccc 120
agtggaaggc acttccgcgt tcggcagaat caaccagagt atgccccagg ctggtttggg 180
agcaagtggc actggctgtt aatcttcctc atgtttttgg tgatcctgaa gtttcctgga 240
ggcgatgacg aaagtaatgc gggcactcct cctggccgtc agggctgttc atctggctct 300
ccaggaagaa agaagataag ggattccccc tacaaagagt ctatgtgcgg tgccttaacc 360
cagtccgaga cgtcactgat gaaccttatg tccagggtga agaatatgaa actcactgcg 420
gcaaccggtg atcaatgcca atgtcccaat atcgaggttc ctggtgacgc acggaataat 480
gttacaatac ttgaggtatg ggacaccgga gaccctgatg aagtggattt tcgcatcaaa 540
gaagaaaagg agtag 555
<210>156
<211>181
<212>PRT
<213>牛
<400>156
Met Arg Ser Val Ile Trp Leu Phe Phe Trp Pro Thr Leu Ile Ser Phe
1 5 10 15
Val Phe Ala Tyr Val Phe Tyr Val Leu Arg Asp Glu Ala Glu Glu Leu
20 25 30
Pro Trp Met Val Pro Ser Gly Arg His Phe Arg Val Arg Gln Asn Gln
35 40 45
Pro Glu Tyr Ala Pro Gly Trp Phe Gly Ser Lys Trp His Trp Leu Leu
50 55 60
Ile Phe Leu Met Phe Leu Val Ile Leu Lys Phe Pro Gly Gly Asp Asp
65 70 75 80
Glu Ser Asn Ala Gly Thr Pro Pro Gly Arg Gln Gly Cys Ser Ser Gly
85 90 95
Ser Pro Gly Arg Lys Lys Ile Arg Asp Ser Pro Tyr Lys Glu Ser Met
100 105 110
Cys Gly Ala Leu Thr Gln Ser Glu Thr Ser Leu Met Asn Leu Met Ser
115 120 125
Arg Val Lys Asn Met Lys Leu Thr Ala Ala Thr Gly Asp Gln Cys Gln
130 135 140
Cys Pro Asn Ile Glu Val Pro Gly Asp Ala Arg Asn Asn Val Thr Ile
145 150 155 160
Leu Glu Val Trp Asp Thr Gly Asp Pro Asp Glu Val Asp Phe Arg Ile
165 170 175
Lys Glu Glu Lys Glu
180
<210>157
<211>1045
<212>DNA
<213>牛
<400>157
cttctgggtc ttgggcggcc attagagagg gagtacctca gcgtggcagc caccccgaat 60
tatgcctact gatagaaagt cgacccgggg gaggattcgg tcgaggaccc gggcaaggat 120
ccgagcactg cggcgggcgc gctccaagaa ggtcaatttg ggaggggaga gcagtgcgga 180
gaaccgtgcg gagaacccag cgatggggtc acagcctagg ggtagcatgg cgtccgcaca 240
gcagtctagg gggcaggccg catctgtgca cggcgtccgg ggtgggacac gccggtctac 300
actaaaggtg tgggtcagcc agcgcttcgg gctgttcctg ctaggtttct ggttcctcct 360
gctgctgtgc ttctacatga gtactgggta tatggattct gtatctgcaa ataactatat 420
tctgtggagc agtgaaaatg ctgatggaca atctctgaat gaaacttctg ccttgagatc 480
tctgataaga tttttctttc caacaacatg cgttccagtg gagggtcagg tgctaacgcc 540
ttgcaagcag gggcaagatc ttaacaagga tgaatgtttg aaatacaaat gctgttactc 600
ttcaatcgag accgctacgg ttagctgttt tgcccctctg agagacaagc ctacgcagat 660
gttccggatg tttgggtttg gtgcgatgag catggtcttc ctgggatgtc tgcccatgta 720
ttgctgctct ttttgctgga agagtagatg ggctggtctt ttacgaagaa gattcaacag 780
aactttaaag cgtttgaaga aacacagaaa gaaaccaaag agggatactg aaatgttgga 840
aacagcagtg gatgaggaag gatatggtga tgaaaaggac caggagacta cagcattatt 900
ttcccagtga gaagaacgcg tacctttcag agaagaggag actgtcccag tcatctaaat 960
ctgctggaac gttttagaag gataaaaact tttgttgtgc ttattttcaa atataaaata 1020
aagttgtagt ttagttttgt gcatc 1045
<210>158
<211>282
<212>PRT
<213>牛
<400>158
Met Pro Thr Asp Arg Lys Ser Thr Arg Gly Arg Ile Arg Ser Arg Thr
1 5 10 15
Arg Ala Arg Ile Arg Ala Leu Arg Arg Ala Arg Ser Lys Lys Val Asn
20 25 30
Leu Gly Gly Glu Ser Ser Ala Glu Asn Arg Ala Glu Asn Pro Ala Met
35 40 45
Gly Ser Gln Pro Arg Gly Ser Met Ala Ser Ala Gln Gln Ser Arg Gly
50 55 60
Gln Ala Ala Ser Val His Gly Val Arg Gly Gly Thr Arg Arg Ser Thr
65 70 75 80
Leu Lys Val Trp Val Ser Gln Arg Phe Gly Leu Phe Leu Leu Gly Phe
85 90 95
Trp Phe Leu Leu Leu Leu Cys Phe Tyr Met Ser Thr Gly Tyr Met Asp
100 105 110
Ser Val Ser Ala Asn Asn Tyr Ile Leu Trp Ser Ser Glu Asn Ala Asp
115 120 125
Gly Gln Ser Leu Asn Glu Thr Ser Ala Leu Arg Ser Leu Ile Arg Phe
130 135 140
Phe Phe Pro Thr Thr Cys Val Pro Val Glu Gly Gln Val Leu Thr Pro
145 150 155 160
Cys Lys Gln Gly Gln Asp Leu Asn Lys Asp Glu Cys Leu Lys Tyr Lys
165 170 175
Cys Cys Tyr Ser Ser Ile Glu Thr Ala Thr Val Ser Cys Phe Ala Pro
180 185 190
Leu Arg Asp Lys Pro Thr Gln Met Phe Arg Met Phe Gly Phe Gly Ala
195 200 205
Met Ser Met Val Phe Leu Gly Cys Leu Pro Met Tyr Cys Cys Ser Phe
210 215 220
Cys Trp Lys Ser Arg Trp Ala Gly Leu Leu Arg Arg Arg Phe Asn Arg
225 230 235 240
Thr Leu Lys Arg Leu Lys Lys His Arg Lys Lys Pro Lys Arg Asp Thr
245 250 255
Glu Met Leu Glu Thr Ala Val Asp Glu Glu Gly Tyr Gly Asp Glu Lys
260 265 270
Asp Gln Glu Thr Thr Ala Leu Phe Ser Gln
275 280
<210>159
<211>2058
<212>DNA
<213>牛
<400>159
atgacctttc gggcgctaag gacccttctg ctcttcagta tactgctttg gggctatgtg 60
ttccagggct gtggtccttc cccttgcaag acatctgtgt gtcaggacct cctggatctc 120
tacttggcct ctgggaacac cagtgtggcc ccctgcactg atttctttag ctttgcctgt 180
ggaaacatca acaggactgg cagtcctttt caggctcttg cagaggagaa caagcgacga 240
gttcgaagaa tcctggaaac cccaggttcc tggcgcctgg cccctgggga ggagaaagcc 300
tttgaattct acaactcctg catgaacatg agtgccattg aggcagcagg ggccagtccc 360
ttcagacagg ttattgagga gcagcttggc ggctggtcga tcttcggtaa ctggactccg 420
ttagatttta accaaactct gagccttctg atgagtcaat atggtcactt cccattcttc 480
agagcctatt tgaaacctct tcccacccct ccatacttgc cagtcatcca ggtgatagac 540
cagccagagc ttgacgttct cctcaagcaa aaacaggaac cgaactatgc ccagatcctg 600
cgggaatacc tgagttacct gaatcgcctg gtaaccttgc tgggaggaga cccaaccaaa 660
gtgggaaacg atgcctccta ttcectcttc attaactcac agctgaacca gttcctgagg 720
cctggggagc agcagcaggc ccagggcaag gtcttcgaga tggtcacaat tgaccagttg 780
cagagagtgg cccctgccat cgactggttg tcctgcttgc aagcaacgtt cgcaccgatg 840
tccctgagcc cctcttattg cgtcgcagtc catgacctgg agtatttgaa aaacatgtca 900
caactgattg agaaggacct gatgaagcac agggactttc tgcaaagcca cataatcttc 960
gggctggtga agacactttc tccagccctg gacagtcagt tccaagaggc acacagatcg 1020
ctgagccaga aagtggggga actgacagga cgcccaccca tgccagtcca ccctcgctgg 1080
atgacgtgcg tggagaagac agaagctttc ttcgagccca cactggccac cttgttcatc 1140
aaggagactt tcaaacccag cacccatagt gctgccatgg aattattcac taccatcaag 1200
gataccttca tctctcacct tcatacagtt ccctggatgg atagagagac ccgggcagag 1260
gcccaggaca ggcttaccca actgcaggtg aagatggggc cctctgagtg ggccctgaag 1320
ccagacccgg ccagacagga atacgacgac gtgcagcttg gacccagctt cctccagacc 1380
ttcctgagct gcatccgctc ccgccaagcc agagtcatcc aggggttctt gcagcctttc 1440
tccagtcaca ggtggcaggt gctcccctgg ggcctcaagg cttcctattc aatacctgac 1500
cacgtgatgg tcttcccagc cggactcctc caacccccat ttttccaccc tggctacccc 1560
agagctgtga actttggcgc tgctggcagc attatggccc gtgagctgtt gcacatcttt 1620
gaccagctct tactccctgg aggctgccca gcctgtgaca cccgtgacct gcagaaggca 1680
ctgctgtgcc tggaacgcct ctatgctgcc ttaccgtcac ccaagggaac ctccttcaat 1740
gtctcccgca cgcttctgga ggatgctgca gacgccgggg cactggccat cgcactgaag 1800
gcatacaaaa agaggctagt tctgttccgt ggggaaacca tcctgcccaa cctagacctc 1860
agcccccggc aactcttctt ccgaagctat gcccaggtga tgtgtaggga ccccagcacc 1920
caggatcctc aggacattcg cagccctcct acccttcgag tccacgggcc cctaagcgac 1980
agtccagctt tcaccagaca ctttcgctgt ccccaggggg ccctcctgaa cccccccagc 2040
cgctgccaac tctggtaa 2058
<210>160
<211>685
<212>PRT
<213>牛
<400>160
Met Thr Phe Arg Ala Leu Arg Thr Leu Leu Leu Phe Ser Ile Leu Leu
1 5 10 15
Trp Gly Tyr Val Phe Gln Gly Cys Gly Pro Ser Pro Cys Lys Thr Ser
20 25 30
Val Cys Gln Asp Leu Leu Asp Leu Tyr Leu Ala Ser Gly Asn Thr Ser
35 40 45
Val Ala Pro Cys Thr Asp Phe Phe Ser Phe Ala Cys Gly Asn Ile Asn
50 55 60
Arg Thr Gly Ser Pro Phe Gln Ala Leu Ala Glu Glu Asn Lys Arg Arg
65 70 75 80
Val Arg Arg Ile Leu Glu Thr Pro Gly Ser Trp Arg Leu Ala Pro Gly
85 90 95
Glu Glu Lys Ala Phe Glu Phe Tyr Asn Ser Cys Met Asn Met Ser Ala
100 105 110
Ile Glu Ala Ala Gly Ala Ser Pro Phe Arg Gln Val Ile Glu Glu Gln
115 120 125
Leu Gly Gly Trp Ser Ile Phe Gly Asn Trp Thr Pro Leu Asp Phe Asn
130 135 140
Gln Thr Leu Ser Leu Leu Met Ser Gln Tyr Gly His Phe Pro Phe Phe
145 150 155 160
Arg Ala Tyr Leu Lys Pro Leu Pro Thr Pro Pro Tyr Leu Pro Val Ile
165 170 175
Gln Val Ile Asp Gln Pro Glu Leu Asp Val Leu Leu Lys Gln Lys Gln
180 185 190
Glu Pro Asn Tyr Ala Gln Ile Leu Arg Glu Tyr Leu Ser Tyr Leu Asn
195 200 205
Arg Leu Val Thr Leu Leu Gly Gly Asp Pro Thr Lys Val Gly Asn Asp
210 215 220
Ala Ser Tyr Ser Leu Phe Ile Asn Ser Gln Leu Asn Gln Phe Leu Arg
225 230 235 240
Pro Gly Glu Gln Gln Gln Ala Gln Gly Lys Val Phe Glu Met Val Thr
245 250 255
Ile Asp Gln Leu Gln Arg Val Ala Pro Ala Ile Asp Trp Leu Ser Cys
260 265 270
Leu Gln Ala Thr Phe Ala Pro Met Ser Leu Ser Pro Ser Tyr Cys Val
275 280 285
Ala Val His Asp Leu Glu Tyr Leu Lys Asn Met Ser Gln Leu Ile Glu
290 295 300
Lys Asp Leu Met Lys His Arg Asp Phe Leu Gln Ser His Ile Ile Phe
305 310 315 320
Gly Leu Val Lys Thr Leu Ser Pro Ala Leu Asp Ser Gln Phe Gln Glu
325 330 335
Ala His Arg Ser Leu Ser Gln Lys Val Gly Glu Leu Thr Gly Arg Pro
340 345 350
Pro Met Pro Val His Pro Arg Trp Met Thr Cys Val Glu Lys Thr Glu
355 360 365
Ala Phe Phe Glu Pro Thr Leu Ala Thr Leu Phe Ile Lys Glu Thr Phe
370 375 380
Lys Pro Ser Thr His Ser Ala Ala Met Glu Leu Phe Thr Thr Ile Lys
385 390 395 400
Asp Thr Phe Ile Ser His Leu His Thr Val Pro Trp Met Asp Arg Glu
405 410 415
Thr Arg Ala Glu Ala Gln Asp Arg Leu Thr Gln Leu Gln Val Lys Met
420 425 430
Gly Pro Ser Glu Trp Ala Leu Lys Pro Asp Pro Ala Arg Gln Glu Tyr
435 440 445
Asp Asp Val Gln Leu Gly Pro Ser Phe Leu Gln Thr Phe Leu Ser Cys
450 455 460
Ile Arg Ser Arg Gln Ala Arg Val Ile Gln Gly Phe Leu Gln Pro Phe
465 470 475 480
Ser Ser His Arg Trp Gln Val Leu Pro Trp Gly Leu Lys Ala Ser Tyr
485 490 495
Ser Ile Pro Asp His Val Met Val Phe Pro Ala Gly Leu Leu Gln Pro
500 505 510
Pro Phe Phe His Pro Gly Tyr Pro Arg Ala Val Asn Phe Gly Ala Ala
515 520 525
Gly Ser Ile Met Ala Arg Glu Leu Leu His Ile Phe Asp Gln Leu Leu
530 535 540
Leu Pro Gly Gly Cys Pro Ala Cys Asp Thr Arg Asp Leu Gln Lys Ala
545 550 555 560
Leu Leu Cys Leu Glu Arg Leu Tyr Ala Ala Leu Pro Ser Pro Lys Gly
565 570 575
Thr Ser Phe Asn Val Ser Arg Thr Leu Leu Glu Asp Ala Ala Asp Ala
580 585 590
Gly Ala Leu Ala Ile Ala Leu Lys Ala Tyr Lys Lys Arg Leu Val Leu
595 600 605
Phe Arg Gly Glu Thr Ile Leu Pro Asn Leu Asp Leu Ser Pro Arg Gln
610 615 620
Leu Phe Phe Arg Ser Tyr Ala Gln Val Met Cys Arg Asp Pro Ser Thr
625 630 635 640
Gln Asp Pro Gln Asp Ile Arg Ser Pro Pro Thr Leu Arg Val His Gly
645 650 655
Pro Leu Ser Asp Ser Pro Ala Phe Thr Arg His Phe Arg Cys Pro Gln
660 665 670
Gly Ala Leu Leu Asn Pro Pro Ser Arg Cys Gln Leu Trp
675 680 685
<210>161
<211>546
<212>DNA
<213>牛
<400>161
atgcgctctg taatatggtt atttttttgg cctacgttta tctcgtttgt ctttgcctat 60
gtgttttatg ttctgagaga tgaagccgaa gaactgccga ggatggtgcc cagtggaagg 120
cacttccgcg ttcggcagaa tcaaccagag tatgccccag gctggtttgg gagcaagtgg 180
cactggctgt taatcttcct catgtttttg gtgatcctga agtttcctgg aggcgatgac 240
aaaagtaatg cgggcactcc tcctggccgt cagggctgtt catctggctc tccaggaaga 300
aagaagataa ggccttcccc ctacaaagac tctatgtgcg gtgccttaac ccagtccgag 360
acgtcactga tgaaccttat gtccagggtg aagaatatga aactcactgt ggcaaccggt 420
gatcaatgcc aatgtcccaa tatcgaggtt cctggtaacg cacggaataa tgttacaata 480
cttgaggtat gggacaccgg agacccggat gaagtggatt ttcacatcaa agaagaaaag 540
gagtag 546
<210>162
<211>181
<212>PRT
<213>牛
<400>162
Met Arg Ser Val Ile Trp Leu Phe Phe Trp Pro Thr Phe Ile Ser Phe
1 5 10 15
Val Phe Ala Tyr Val Phe Tyr Val Leu Arg Asp Glu Ala Glu Glu Leu
20 25 30
Pro Arg Met Val Pro Ser Gly Arg His Phe Arg Val Arg Gln Asn Gln
35 40 45
Pro Glu Tyr Ala Pro Gly Trp Phe Gly Ser Lys Trp His Trp Leu Leu
50 55 60
Ile Phe Leu Met Phe Leu Val Ile Leu Lys Phe Pro Gly Gly Asp Asp
65 70 75 80
Lys Ser Asn Ala Gly Thr Pro Pro Gly Arg Gln Gly Cys Ser Ser Gly
85 90 95
Ser Pro Gly Arg Lys Lys Ile Arg Pro Ser Pro Tyr Lys Asp Ser Met
100 105 110
Cys Gly Ala Leu Thr Gln Ser Glu Thr Ser Leu Met Asn Leu Met Ser
115 120 125
Arg Val Lys Asn Met Lys Leu Thr Val Ala Thr Gly Asp Gln Cys Gln
130 135 140
Cys Pro Asn Ile Glu Val Pro Gly Asn Ala Arg Asn Asn Val Thr Ile
145 150 155 160
Leu Glu Val Trp Asp Thr Gly Asp Pro Asp Glu Val Asp Phe His Ile
165 170 175
Lys Glu Glu Lys Glu
180
<210>163
<211>610
<212>DNA
<213>牛
<400>163
atgcgctctg taatatggtt atttttttgg cctacgttta tctcgtttgt ctttgcctat 60
gtgttttatg ttctgagaga tgaagccgaa gaactgccga ggatggtgcc cagtggaagg 120
cacttccgcg ttcggcagaa tcaaccagag tatgccccag gctggtttgg gagcaagtgg 180
cactggctgt taatcttcct catgtttttg gtgatcctga agtttcctgg aggcgatgac 240
aaaagtaatg cgggcactcc tcctggccgt cagggctgtt catctggctc tccaggaaga 300
aagaagataa ggccttcccc ctacaaagag tctatgtgcg gtgccttaac ccagtccgag 360
acgtcactga tgaaccttat gtccagggtg aagaatatga aactcactgt ggcaaccggt 420
gatcaatgcc aatgtcccaa tatcgaggtt cctggtgacg cacggaataa tgttacaata 480
cttgaggtat gggacaccag agacccggat gaagtggatt ttcacatcaa agaagaaaag 540
gagtagttga gtgttgacaa agtgtatcca aactaataaa agtattttge agcaaaagga 600
aaaatgcctc 610
<210>164
<211>181
<212>PRT
<213>牛
<400>164
Met Arg Ser Val Ile Trp Leu Phe Phe Trp Pro Thr Phe lle Ser Phe
1 5 10 15
Val Phe Ala Tyr Val Phe Tyr Val Leu Arg Asp Glu Ala Glu Glu Leu
20 25 30
Pro Arg Met Val Pro Ser Gly Arg His Phe Arg Val Arg Gln Asn Gln
35 40 45
Pro Glu Tyr Ala Pro Gly Trp Phe Gly Ser Lys Trp His Trp Leu Leu
50 55 60
Ile Phe Leu Met Phe Leu Val Ile Leu Lys Phe Pro Gly Gly Asp Asp
65 70 75 80
Lys Ser Asn Ala Gly Thr Pro Pro Gly Arg Gln Gly Cys Ser Ser Gly
85 90 95
Ser Pro Gly Arg Lys Lys Ile Arg Pro Ser Pro Tyr Lys Glu Ser Met
100 105 110
Cys Gly Ala Leu Thr Gln Ser Glu Thr Ser Leu Met Asn Leu Met Ser
115 120 125
Arg Val Lys Asn Met Lys Leu Thr Val Ala Thr Gly Asp Gln Cys Gln
130 135 140
Cys Pro Asn Ile Glu Val Pro Gly Asp Ala Arg Asn Asn Val Thr Ile
145 150 155 160
Leu Glu Val Trp Asp Thr Arg Asp Pro Asp Glu Val Asp Phe His Ile
165 170 175
Lys Glu Glu Lys Glu
180
<210>165
<211>1080
<212>DNA
<213>马
<400>165
atggcgacca cattagatgg gactgagact gtgggtgagg ctgaaggaac cacaccttat 60
gactatgatg ggtcactgcc atgtgaaaaa atcaacatca agatgctggc ggcccagttc 120
ctgcccccac tgtattctct ggtggtcgtg attggtctgc tgggcaatct gatggtggtg 180
gtgatcctca caaaatacaa gaggctccgg attatgacca acatcttcct gttcaatttg 240
gcaatttctg acttgctctt tcttttcact ctgccattct ggattcacta tgtttggcgg 300
gatgagtggg tttttggcca tcacatgtgt aagttcctca ttgggctttg ttacacgggc 360
ttgtacagcg agatcttttt catcatcctg ttgacgctag accggtatct ggccatcgtc 420
cacgctgtgt ttgcccttcg aacccggacc gtcacttttg gcatcataac cagtgtcttc 480
acctggggcc tggcagggct agcagccctc cctgaattta tcttccatgg gttccaagag 540
gaatttggtc agtatgtctg ccttcctttc tacccagaag cagcagaaaa tatctggaag 600
agtacccatg ttctgagaat gaatatcttg agtctcgctc tgcctttgct cattatggct 660
gtctgctact caggaatcat taaaacactg ctgagatgtc ctaacaagaa aaagtacaag 720
gccatccggc tcatttttgt catcatggtg gtctttttcg ttttctgggc accttacaac 780
ctggttctct ttttctccac ttttcaaaca accttccttg ggaccagctg tgatcagagc 840
aaacagctgg acatggccct gctggtgaca gagatgatcg cctacacgca ctgctgtgtc 900
aaccctgtga tctacgcatt tgttggcgag aggttccaga agaacctcca ccactttttc 960
cacacgtacg tggccatcta cctgtgcaaa tacatcccat tccttcctag tgagaaattg 1020
gaaagagcca gctctgtatc cccatcaaca ggggagcagg aactctctgc tgcattttag 1080
<210>166
<211>3700
<212>DNA
<213>马
<400>166
agatgaagga caccatgtga tggagccacc tgtcatcacg gaacagtctc cacggcgcct 60
ggttgtcttc cccacagacg acatcagcct caagtgtgag gccagtggca aacccgaagt 120
ggagttccgc tggactcatg atggcgttca cttcaaaccc aaggaggaac tgggtgtgac 180
cgtgcaccag gagccccact ctggctcctt caccatcacg ggcaacaaca gcaactttgc 240
ccagaggttc cagggcacct atcgctgctt tgccagcaat aagcttggca ccgccatgtc 300
ccacgagatc cagctcatgg ccgagggtgc cccaaagtgg ccaaaggaaa cagtgaaacc 360
tgttgaggtg gaggaagggg agtcggtgat tctgccttgc caccctccac ccagtgcaga 420
gcctcttcgg atctactgga tgaacagcaa gatcttgcac atcaaacagg atgagcgggt 480
aacaatgggc cagaacggca acctctactt tgccaatgtg ctcacctcgg acaaccactc 540
agactacatc tgcaatgccc acttccctgg cacccggacc atcattcaaa aggaacccat 600
tgacctccga gtcaaggcca ccaacagcat gatcagcagg aagccgcgcc tgctcttccc 660
caccaactcc agcagccacc tggtggcctt gcagggacag ccactgatcc tggagtgcat 720
tgccgagggc tttcccacgc ccaccatcaa gtggctgcgc ccaagtggcc ccatgccatc 780
cgaccgagtc acctaccaga accacaacaa gaccctgcag ctgctgaatg tgggagagga 840
ggatgacggc gagtatcgct gcctggctga gaactcgctg ggcagtgacc ggcatgccta 900
ctatgtcact gtggaggctg ccccgtactg gctgcaaaag ccccagagcc atttgtatgg 960
gccaggagag accgtccgcc tggactgcca ggtgcagggc aggccccaac cagaggtcac 1020
ctggagaatc aatgggatcc ccgtggagga gctggccaag gaccagaagt accggatcca 1080
gcgtggagcc ctgatcctga gcaacataca gcccagtgac acgatggtga cccagtgtga 1140
agcccgcaac cggcacgggg tcctgctggc caatgcctac atctatgtcg tccagctacc 1200
agccaagatc ctgaccccag acaacgagac gtacatggca gttgagggca gcactgccta 1260
ccttctgtgc aaggcctttg gagcacctgt gcccagcgtc cagtggctgg acaaggaagg 1320
gaagaccgtg ctgcaggacg agcgcttctt cccttacacc gacgggaccc tgggcatccg 1380
agacctccaa gccaacgaca ctggacacta cttctgccag gctgccaatg accaaaataa 1440
cgtgaccatt gtggctaacc tgcaggtcaa agatgccact cagatcacgc aggggccccg 1500
gagtgcaatc gagaagaaag gttcaagagt gacattcacg tgccaggcct cctttgaccc 1560
ctccttggag cacagcatca cctggcgtgg ggatggtcac aacctccagg agcttggtga 1620
cagtgacaag tacatcatag aggatgggcg cctggtcatc cacagcctgg actacagtga 1680
ccagggcaac tacagctgtg tggctggcac caagctggat gtggtggaga gcagggcaga 1740
gctcctggtg gtgggtgacc ccgggccggt gccgcagctg gagctgtctg atcatcactt 1800
gctgaagcag agccaggtgc gcctgtcttg gagccccgcc gatgaccaca acgcccccat 1860
cgagaagtat gacattgaat ttgaggacaa ggagatggcg cctgagaaat ggtacagtct 1920
gggcaaggtg ccagggaacc agacctccac caccctcaag ctgtcaccct atgtccacta 1980
cacctttaga gtcactgcca tcaacaaata cggccctggg gagcccagcc cggcctctga 2040
gactgtggtc acacctgagg cagccccgga aaagaaccct gtggacgtga agggggaagg 2100
gaacgagacc aacaacatgg tcgtcacttg gaagccgctc aagtggatgg actggaatgc 2160
cccccaggtt cagtaccgcg tgcagtggcg ccctcagggg acgcggggga cctggcagga 2220
acagatcgtg agcgacccct tcctggtagt gtccaacacg tccacttttg tgccctatga 2280
gatcaaggtc caggccgtca acagccaggg caagggccct gagcctccga tcaccattgg 2340
ctactctggg gaagactacc cccaggcaag ccctgagctg gaaggcatca agatcctcaa 2400
ctcaagcact gtgctggtca ggtggtggcc tgtggaccca gccctggtca agggccacct 2460
ccgaggatac aatgtgacgt actggtggga gggcagtcag aggaagcaca gcaagaggca 2520
cgtccacaaa ggccacatgg tggtgcccgc caacgccacc agtgccatcc tggggggcct 2580
gcggccttac agcttctacc atctggaggt ccaggccttt aatggccgag gtctggggcc 2640
tgcgagcgag atgaccttcc acaccccaga aggagtgccc ggccaccctg aagcactgca 2700
cctggagtgc cagtcaaaca ccagcctgct gctgcactgg cagcccccac tcagccacaa 2760
cggcgtgctc actggctacg tgctctccta ccaccctctg gacaatgggg gcaaggagca 2820
gttgtccttt gaccttccgg accctgagct gcgttcgcac aacctgagca acctcagccc 2880
ccaactgcgg taccgcttcc agctgcaggc caccacgaag gagggccctg gcgaggccat 2940
cgtgcgggaa ggaggcacca tggccctagc tggaaaccga agttttggca acatctcggc 3000
catggctggc gagaattata gcgtggtctc ctgggtgccc agggagggcc gatgcaactt 3060
cgggttccag atctggttca aagccttggg ggatgagaag atgggcgctc gtctcacacc 3120
gcagtccgtc agctacaacc agagctccta cacacagtgg gacctgcagc ccgacaccca 3180
ctacgagatc cacctgctca aggagacagt gctcctgcac cagatggctg tgaagaccaa 3240
tggcaccagc catgtgagac tccctcctgc cggcttcacc accgagggct ggttcatcgg 3300
cttcgtgagc gctgctgtcc tcctgctcct cgtcttgctc atcctctgct tcatcaagcg 3360
cagcaagggt ggcaagtatt cagtgaagga taaagaggac acccaggtgg actctgaagc 3420
ccggccaatg aaggacgaga cctttggcga gtacaggtcc ttggagagtg acaatgagga 3480
aaaggccttt ggcagcagcc agccatccct caacggagac atcaagccgc tgggtagtga 3540
cgacagccta gccgactacg ggggcagcgt ggatgtccag ttcaatgagg acggctcctt 3600
tattggccag tacagcggca agaaggagaa ggaggcgaca ggaggcaatg acagctcagg 3660
ggccgcctcc cccatcaacc ccgcagggac cttggagtag 3700
<210>167
<211>1071
<212>DNA
<213>马
<400>167
atgcccaccc acttccctga gccgatctcg gacgattttc agtacgatga gtctgcagaa 60
gcctgtaaca tggaggacat cgtggtcttt gggactgcct tcctgtccgt ggtctactcc 120
cttgtctttg tgttcggcct ggtgggaaat ttgctggtga tcttttccct cagcaacagc 180
cggaagcgca agagcatcac cgacatttac ctcctgaacc tggccttgtc cgatctgctt 240
tttgtagcca ctttgccctt ctggactcac tatctgagaa gtgaacaagg ctttcacaat 300
gccgtgtgca aactcaccac tgccttcttc ttcatcgggt tttttggagg catcttcttc 360
atcaccatca tcagcatcga taggtacctg gccattgtcc tggccgccaa ctccatgaac 420
aaccggactg tgacgcacgg cgtcaccatc agcctgggcg tctgggcagc agccatcttg 480
gtggcagcac cccagttcat gttcacaaaa caaaaagaaa atgaatgcct tggtgactac 540
cccgaggtcc tgcaggacat ctggcccgtg ctccgcaatg tagaagcaaa tgctcttggc 600
ttcctgctcc cgctgctcat tttgatctac tgttacttca gaatcatgcg gacgctgttc 660
tcctgcaaga accgcaagaa agctaaagct attaaactga tccttctggt ggtcatcgta 720
tttttcctct tctggacacc ctacaacatc atgattttct tagagacgct caatctctac 780
gacttctttc cggattgtga catgaaaagg gatctgaaat tggccatcgg tgtgaccgag 840
acaatagcat ttatccactg ttgcctcaat cccattatct atgcctttgc tggagagaag 900
ttcagaagat acctttccca cctgtacagg aaatgcctgg ctgtcctgtg ctgttattct 960
gtcgacaccg gtttctcccc gcctgagtca caaacaggca ggcgggaaag cattctgagc 1020
agcaatttta cccactacac cagtgatgga gaggtgtccc tccatgtctg a 1071
<210>168
<211>579
<212>DNA
<213>马
<400>168
gtgggatgga tcctctccac catttgcatg ggctttgcgg agtggcgagt gtggtacatg 60
aacaacacct cactcctccc ctcgggcctg gcccgtgtgg gaatgtggaa aatctgcatt 120
tactaccatg ctgacaactt ctacagagcc acatcgtgtt accattacac ctactgtgat 180
acttttctcc ctcttgatat tcgtattgct caaaacctcc tgctgatcgc cagcattcta 240
gggctcttgg ggaaagcctc catcaccttt gcacttagga atgtgtacat gggaattctt 300
aggaagaatg ccacctgcaa tgcatttgtt gcttcaggaa ttctgaacat agctgctggt 360
gtctgtatct ccgtagctgt gacctggaat taccactcag tgatgaatga agaggaaatt 420
gccttcccac catatttcta tgtgcccttc aagccggatg ctcaggaaat tggcaatgcc 480
attatcgtgg catgtctggc tgccttcctg atgttgttaa gtggactgtg tttcctctct 540
tataaattcc ccctggacag ccacgtgtgt cctgaaatt 579
<210>169
<211>3792
<212>DNA
<213>马
<400>169
ttccagggat cacaggagtt ggtacaaatt gcttgataat ctgcagcgtt ctctctagga 60
tttagctgcc attgtgttag caaattttca catgttggta ggcagatggt cccaccttta 120
ccctcgcacc tgtcagtgtg ctggagaaga gaaacgagtt ggtacacgca cagtgtttgt 180
tggccatcat ccagtttcag aaacagaaac ttatgttgca caaaaatttt gtgataatag 240
aatagtctca tctaagtata cactttggaa tttcctccca aagaatctgt ttgaacagtt 300
tagaagaatt gcgaattttt attttctcat cattttcctt gtacaggtca cagtagatac 360
accaactagc ccagttacca gtggacttcc acttttcttt gttataactg ttacagccat 420
caagcagggt tatgaggatt ggctgagaca cagagctgac aatgaagtca acaagagaac 480
tgtttacatt attgaaaatg caaaacgagt gagaaaagag agtgaaaaaa tcaaggtcgg 540
tgatgtagtc gaagtacagg cagatgaaac ctttccctgt gatcttattc ttctatcatc 600
ctgcactagt gatggaacct gttatgttac tacagccagt cttgatgggg aatccaattg 660
caagacacat tatgcggtac gtgataccat tgcactgtgt acggctgagt ccattgatac 720
cctccgagca gcaattgaat gtgaacagcc tcaacctgac ctctataagt ttgttggacg 780
aatcaatatc cgtaataata atcttgaggc tgttgccagg tctttgggac ctgaaaatct 840
cttgttgaaa ggagctacat taaaaaatac caagaagata tatggagttg ctgtttacac 900
tgggatggaa actaaaatgg ctttgaacta ccaaggcaaa tctcagaaac gttctgctgt 960
tgaaaaatcc attaatgcct tcctgattgt gtatttattt atcttactga ccaaagctgc 1020
tgtatgcact acgctaaagt atatttggca aagtatccca tataacgatg aaccttggta 1080
taaccaaaag acccagaaag agcgggagac tttcaaggtt ttgaaaatgt tcaccgactt 1140
cctgtcattt atggttctat tcaactttat cattcctgtc tccatgtatg tcacagtaga 1200
aatgcagaaa ttcttgggct ccttcttcat ttcatgggat aaggactttt atgatgaaga 1260
aattaatgaa ggagccctgg ttaacacatc agaccttaat gaagaacttg gtcaggtgga 1320
ttatgtgttt acagataaga ctggaacact cactgaaaac agcatggaat tcgttgaatg 1380
ctgcatagat gggcacaaat ataaaggtgt aactcaggag gctgatggac tctctcaaac 1440
tgatggaccc ttaacatatt ttgacaaagc agataagaat cgagaagagc tctttctgcg 1500
tgccttgagt ttatgtcata ctgtagaaat taaaacaaat gatgctgttg atggagctcc 1560
agaatcgtct gaattagcct atatgtcctc ttcaccagat gaaatagctt tggtgaaagg 1620
agctaaaaag tatgggttca catttgtggg aattcataat ggccatatga gagtagagaa 1680
ccaaagaaaa gaaatagaag agtatgaact acttcatacc ttaaatttcg atcctgtccg 1740
ccgtcgtatg agtgtaattg tgaagactca agcaggagac atacttctct tttgtaaagg 1800
agcagactca gcagttttcc ccagggtgca aaatcatgaa attgagttaa ctaaagccca 1860
tgtggaacgt aatgcggtgg atgggtatcg gacactctgt gtggccttca aagaaattgc 1920
tccagatgat tatgaaagga ttgaccgaca gcttatagag gcgaaaatgg ccttacagga 1980
cagagaagaa aaaatggaaa aggtttttga tgatattgag acaaacatga atttaattgg 2040
agccactgca gtggaagaca agctccaaga tcaagcagct gagaccattg aagctctcca 2100
tgctgcaggt ctgaaagtct gggtgcttac tggggacaag atggagacag ccaaatccac 2160
ctgctatgcc tgccgccttt tccaaaccaa cacagagctc ttggaactga ccacaaaaac 2220
catcgaagaa tgtgaaagga aagaagatcg attacatgaa ttgttaatag aatattgtaa 2280
gaagttgcgg catgaatttc ctaaaggttc tagaaacctt aaaaaagcat ggacagaaca 2340
tcaggaatat ggattgatca ttgatggctc cacattgtca ctcatattaa attctagtca 2400
agactccagt tctaacaatt acaaaagtgt ttttctacag atttgcatga agtccactgc 2460
agtgctctgc tcccgtatgg caccgttaca gaaagcccag attgtcagaa tggtgaagaa 2520
tttaaaaggc agcccaataa cactgtcgat aggtgatggt gccaatgatg ttagtatgat 2580
cttggaatcc catgtgggaa taggtattaa aggcaaagaa ggtcgccaag cagccaggaa 2640
tagcgattat tctgttccaa agtttaaaca tttgaaaaaa ctgctattgg ctcatgggca 2700
tctatattat gtgagaatag cacaccttgt acagtatttc ttctataaga acctttgttt 2760
cattttgcca cagtttttat accagttttt ctgtggattc tcacaacagc cactgtatga 2820
tgccgcttac cttacaatgt acaatatctg cttcacatcc ttgcccatcc tggcctacag 2880
tctactggaa cagcacatca acattgatgc tctgacctca gatccccgat tgtatatgaa 2940
aatttctggc aatgccatgc tacagttggg ccccttctta tattggacgt ttctggctgc 3000
atttgaaggg accgtgttct tctttgggac ttattttatt tttcagacat catccctaga 3060
agaaaatgca aaggtatacg gaaactggac ttttggaacc attgttttta cagtcttagt 3120
attcactgta actctgaagc tcgccttgga tactcgtttc tggacttgga taaatcactt 3180
tgtgatttgg ggttctttag ccttttatgt atttttctca ttcttctggg gaggaattgt 3240
ttggcctttt ctcaaacaac agagaatgta tttcgtattt gctcaaatgc tgtcttctgt 3300
atccacatgg ttggccataa ttcttctaat atttatcagc cttttccctg agattctcct 3360
gattgtatta aagaatgtaa gaagaagaag tgccaggaga aatctgagct gtaaaagggc 3420
atctgactca ttatccacca gaccttcagt cagacctctt cttttacgaa cattctcaga 3480
cgaatctaat atattgtaac agaatccgaa tcttgaactg cctatgttat tgtcctacaa 3540
gcatattgac agtggtttca gctaaaaacg aaagcatgaa gaaaactaca aaaagttatc 3600
atctcaggat attcgatatg caacaaacta aaccactctc ttatatctag gattcaaaat 3660
aaatgtccat taaaatacca aatgactctc ttaagcattt acagttattg taagtagcca 3720
ttatggccaa agctctaagt tacgaattat atgaaagttg aaagcaagaa tacttagaat 3780
ttctggcttt ag 3792
<210>170
<211>1391
<212>DNA
<213>马
<400>170
attttcttcc cattcaattc tgctctgttc ttctgccatc tcgttactag acgttggcat 60
tagacgtgac aatcaactcc atttgaactg agcagaagaa atattaaagg cataatcttc 120
agaagaaatg tctcagagac agcctcagtc acctaatgag actttaattt cgatcacaaa 180
tgacacagaa tcatcaagct ctgttgttcc taatgataac acaaaaaaag gacggaccgg 240
agacaactct ccaggaatag aagcattgtg tgccatctac atcacttatg ctgtgatcat 300
ttcagtgggc atccttggaa atgctattct catcaaagtc tttttcaaga ccaaatccat 360
gcaaacagtt cccaatattt tcatcaccag cctggctttt ggagatcttt tacttctgct 420
aacttgtgtg ccagtcgatg caacacacta ccttgcagaa ggatggctgt tcggaagaat 480
tggctgtaag gtgctctcct tcatccggct cacttctgt tggtgtatcag tgttcacgtt 540
aacaattctc agcgctgaca gatacaaggc agttgtgaag cccctggagc gacagccctc 600
caatgccatc ctgaagacct gtgccaaagc tggctgcgtc tggatcgtgt ctatgataat 660
tgctctacca gaggctatat tttccaatgt ttatactttt caagatccca acagaaacag 720
gacatttgaa gcgtgtgcct cttatcctgt ttctgagagg ctcctgcaag agatacactc 780
tctgctctgc ttcttggtgt tctaccttat tccactctct atcatctctg tctattattc 840
cttgattgcg agaacgcttt acaaaagcac cttgaacata ccgaccgagg aacaaagcca 900
tgctcgcaag cagattgaat cccggaagag aattgccaag acggtgttag tgctggtggc 960
tctgtttgct ctctgctggt tgccaaatca cctcctgtac ctctaccgtt ccttcactta 1020
tcaaacctac atggatcctt ccgccgttca ttttctcgtc accattttct ctcgggtcct 1080
ggcattcagc aattcttgtg taaacccctt cgctctttat tggctgagca aaaccttcca 1140
gcagcatttt aaagctcagt tgttctgctg caaggcagag gtgcccgacc ccgctcctgc 1200
agatgccact ctcaacagcc tggctgtgat gggaagggtc ccgggggctg ctagcacgca 1260
ggtgtctgaa attagtgtga cctggttcac tgggtgtagt atggagaagg aagatgacag 1320
agtctagctt ttcaattaaa aagggtcttt ttcctgccag cgtgtgtatc cgactctgag 1380
ctgcgcgtag g 1391
<210>171
<211>1373
<212>DNA
<213>马
<400>171
gcggcggcac ggcgacggcg acgacgctgt tcgcgctggc accatgaacc cgctgtaacg 60
cgcagacagc gcggcgcggg gggagggggg aggaggagga cgcggccgcg aagttctccg 120
ccatgaacct gaggggcctc ttccaggact tcaacccgag taaattcctc atctatgcct 180
gtctgctgct gttctctgtg ctgctggccc ttcgtctgga tggcatcatt cagtggagtt 240
attgggctgt ctttgctcca atatggctct ggaagttaat ggtcattgtt ggagcatcag 300
ttggaactgg agtctgggca cgaaatcccc aatatcgagc agaaggagaa acatgtgtgg 360
agttcaaagc catgttaatt gccgtgggca tccacttgct cctgctgatg tttgaagttc 420
tggtctgtga caggattgag agaggaagcc atttctggct tctggtcttc atgccgctgt 480
tcttcgtttc cccggtgtct gttgcagctt gtgtttgggg ctttcgacat gacaggtcac 540
tggagttaga aatcctgtgt tctgtcaaca ttctccagtt tatattcatt gccttaagac 600
tggacaagat catccactgg ccctggcttg tcgtgtgtgt ccccctgtgg attctcatgt 660
cctttctgtg cctggtggtc ctctattaca ttgtgtggtc cgtcctgttc ctgcgctcca 720
tggatgtgat tgcagaacag cgaaggacac acataacaat ggcactgagc tggatgacca 780
ttgttgtgcc tctccttact tttgagatcc tgctggttca caaactggat ggccacaatg 840
cattctcttg tattccaata tttgtccctc tttggctttc tttgatcact ctgatggcaa 900
ccacattcgg acagaaggga gggaaccact ggtggtttgg tattcgcaag gatttctgtc 960
agtttctgct tgaaatattc ccgtttttga gagaatacgg aaatatttcc tatgacctcc 1020
atcatgaaga taatgaggaa accgaagaaa ctccagttcc agaacctccg aaaatcgctc 1080
ctatgtttcg aaagaagacc agggtagtta tcacccagag tcctggaaag tatgtcctcc 1140
cccctcctaa attaaatatt gaaatgccgg attagatgcc atttcctggg acagaacgta 1200
agtggactgg gacacatgct ctcttctacc ttcctctgcc tctttgttca cccccccccc 1260
ccccgaactg gaactggagc tgggtctcca ggaacttcca tctcatgcct tgtttgcact 1320
caatgcctac cagtgactca ccacgacggg acacacaggt ggcaggtgac tgg 1373
<210>172
<211>585
<212>DNA
<213>马
<400>172
atggctgccg aggatgtggc ggcgacaggc gccgacccga gcgagctgga gggcggcggg 60
ttgctacacg agattttcac gtcgccgctc aacctgctgc tgctcggcct ctgcatcttt 120
ctgctctaca agatagtgcg cggggaccag cccggcagcg gcgacagcga cgacgacgag 180
ccgcccccac tgccccgcct taagcggcgc gacttcaccc ctgcggagct gcggcgcttc 240
gacggcgtcc aggacccgcg catactcatg gccatcaacg gcaaagtgtt cgacgtgacc 300
aaaggccgca agttctacgg gcccgagggg ccgtacgggg tctttgctgg aagagatgca 360
tccaggggcc ttgccacatt ctgcctggat aaagaagcac tgaaggacga gtatgatgac 420
ctttctgacc tcactcctgc ccagcaggag accctgagtg actgggactc tcagttcact 480
ttcaagtacc atcatgtggg caaactgctg aaggaggggg aggagcccac cgtgtactca 540
gatgaggaag aaccaaaaga cgagaatgct cggaaaaatg attaa 585
<210>173
<211>2147
<212>DNA
<213>马
<400>173
ccaggagagg agccccccac tgaaaggagc agagtgtggg gcatggtcag gaggatgctg 60
gtgcttgtcc tgattttgag tctgctcctt ggttcttctg tgctcttgtt ctacatcttc 120
gggagctgtg gccctcgtcc ttgtgagacg cgtgtgtgtt gggatctcct ggctcgttac 180
ctggcctctg ggaataccag tgtggctccc tgtaccgact tcttcagttt tgcctgtgga 240
caggccaaag ggatcagtaa ttcttttcag gctcttgcag aggagaacaa gaaccgactt 300
cggagaatac tggaggcccc aggttcctgg cacccgggct ctggggaaga gaaagccttc 360
caattctaca gcttctgcat ggacacagat gccattgagg ctgcaggggc tggtcccctc 420
agacaaatta ttgaggagct tggagggtgg cgaatttctg gtagttggac ttccttggac 480
tttaaccgaa ctctgagact tctgatgagt cagtatgatc acttcccatt cttcagagct 540
gatctgcaac ctcatcccac ccctccacac ttgccagtaa tccagatata ccagccagag 600
tttgaccttc ctgtcaagca agagcaggaa cagaagaact atgctcagat cgtgcgggaa 660
tacctgactt acctgaatca gctgggaacc ttgctgggag gagacgcaag aaaggtgcaa 720
gaacatgctg ccatgtccat ctccattacc tcgcagctgc ttcaattcct gagacccccg 780
gaacagcgac gggcacaggg aaagctcttc cagatggtca ctattgatca actgcaggaa 840
atggcccctg ccattgactg gttgtcctgc ttgcaagcga tattcacatc gatgtccctg 900
agcccctccc agccccttgt ggtccatgac ctggagtatt tgaaaaacat gtcatacctg 960
gtggaagaac agctgtcaaa gcacagggac tttctgcaga gccacatgat cttggggctg 1020
gtggggtccc tttctccagt cttggacagt aaattccagg aggcgcatac tttgctgaac 1080
cagaaactac gggagctgac agaacgacca cccttgccca cccaccctcg atggatgaag 1140
tgcgtgaagg agacaggaga ctacttccag cctaccctgg cagccttgtt tgttcgtgag 1200
gccttcagcc cgagcaccca aagtgctgcc atggaattat tcactgagat caaggatgcc 1260
ctcatcactc gtctcagaag tcttccctgg atggatgaga ggacccagaa agaggcccag 1320
gacaaggtca cgcaacttca agtaaagatg ggggccccag aatgggccct ggagccagca 1380
ctggccagac aggaatacaa cgatatacaa cttggatcca gctacctgca gtcccacctg 1440
agctgtgtcc gatccctccg agctagaatt atccagagct tcttacagcc ttctcctcac 1500
cacaggtggc aggtgcttcc ctgggaggtc aatgcttact actcaatatc tgaccatgtt 1560
gtggtcttcc ctgccggact cttccaaccc ccgttctttc accctggcta ccccagagct 1620
gtgaactttg gcgctgctgg cagcattatg gcccatgagc tgttgcatgt cttctacaag 1680
ctcttactcc ctggaggctg cccagcctgt gacacccgtg ccctacaggg ggcattgctg 1740
tgcctggagc acctctatgc tgcctttcca ttacccagag gagtttcctt caatggctcc 1800
cgcacactcc tggagaatgc tgcagacaca ggggggctag ttattgcact aaaggcatat 1860
agaaagaggc tattatggca ccgcggggag actgtcctac ccaacctgaa cctcagcccc 1920
cagcaactct tcttccgaag ctatgcccag gtgatgtgtg gggatcccag cacccaggat 1980
tctcaggaca ctcacagccc tcccaccctt cgaatccacg ggcccctcag caacatccca 2040
gactttgcca gatatttccg ctgtccacgt ggtgccctca tgaacccttc cagccactgc 2100
ccactctggt aacctggcta ccaaagagac ctcaatacag atctaac 2147
<210>174
<211>1543
<212>DNA
<213>马
<400>174
cggagtccca gtgtggcctg gaggaacgga tctcgtgcca gggcgaccca gtcgggagcc 60
cccagaccga gctcgtgttg tggggagact cccacttctc ccgagggacg ccgatcccgg 120
gacggtcgag gcgttggggc ggctaccgaa ttctcagcgg ggagaccccg ttgggcagag 180
ggcgcgcagt ctcgaacagt ctcggggagc cgagcggaat caggcgggat cacccggggg 240
cgcagagccc ccgtcgtgcc ttgtgcggca cagaggccag gggagagagc cctcggaggc 300
cgaagcccat gcccgggttg ggggcggctg tccagtgagt cctcctggcc cgccggacgg 360
agaagagcga caccgaagcc ggcgggaggg gagcacttca aggccggcgg ctgcggagga 420
tgggcgcctg agcggttcgg agcgcagcgc agcacgggca ggcgaagcgt gctttgctga 480
ggaggcacca ggggatcctg aagtgcagcc tgcccccggg aagatggctc ggcctgggca 540
gcgttggctc ggcaagtggc ttgtggcgat ggtcgtgttg gcactgtgcc ggctcgccac 600
gccactggcc aagaacctgg agcccgtgtc ttggagctcc ctcaacccca actttctggt 660
gggaaagggc ctggtgatct acccaaagat tggagacaag ctggacatca tctgtccccg 720
agcagaagca gggcggccct acgagtacta caagctatac ctggtgcggc ctgagcaggc 780
agctgcctgc agcactgtgc tcgaccccaa cgtgctggtc acctgcaata ggccagagca 840
ggaaatccgc tttaccatca agttccagga gttcagcccc aactacatgg gcctggagtt 900
caagaagcac catgattact acattacctg tgagttcctg gctgacctgc ctggtctgtt 960
ggcagaaccc tttgggatcg gccagctgtt cagcctttct cttcacagga aattttttcc 1020
tgaccccaaa tccaggattc cttctccgtg cacttctagt cttgcccctg gccagtccgg 1080
gggctccctg ggggtattag ggtggtctcc cagagggcag aagccattcc tcggctgccc 1140
tttcaggccc tataccgtga accaagaaga gaaaagcggc agtggggacc ctgacagctt 1200
cttcaactcc aaggtggcat tgttcgcggc cgttggtgct ggctgtgtca tcttcctgct 1260
catcatcatc ttcctgacgg ttctgctact caagctgcgc aagcggcacc gcaagcacac 1320
gcagcaacgg gcacctgccc tctcgctcag taccctggcc agtcccaagg ggggcagtgg 1380
cacggcgggc accgagccca gtgacatcat catcccctta cggactacag agaacaacta 1440
ctgcccccac tatgagaagg tgagtgggga ctacgggcac cccgtctaca tcgtccagga 1500
gatgccaccc cagagcccag cgaacatcta ctacaaggtc tga 1543
<210>175
<211>1884
<212>DNA
<213>马
<400>175
aggtgtattc cttattccct acgtcctgat cgccctgatt ggaggaatcc ccattttctt 60
cttggagatc tcgctgggcc agttcatgaa ggccggcagc atcaatgtct ggaacatctg 120
ccccctgttc aaaggcctgg gctacgcctc catggtgatc gtcttctact gcaacaccta 180
ctacatcatg gtgctggcct ggggcttcta ttacctggtg aagtccttca ccaccacgct 240
gccctgggcc acgtgtggcc atacctggaa cactcccgac tgtgtggaga tcttccgcca 300
cgaagactgt gccaatgcca gcctggccaa cctcacatgt gaccagcttg ctgaccgccg 360
gtccccagtc attgagttct gggagaacaa agtcttgcgg ctttctgggg ggttggaggt 420
accaggggcc ctcaactggg aggtgaccct gtgtctgctg gcctgctggg tgctggtgta 480
cttctgtgtc tggaaggggg tcaagtcaac aggaaagatc gtgtacttca ccgctacatt 540
cccctacgtg gtcctcgttg tgctgctggt gcgtggagtg ctgctgcctg gcgccttgga 600
cggcatcatc tactatctca agcctgactg gtcgaagctg gggtctcctc aggtatggat 660
agatgccggg acccagattt tcttctctta cgccattggc ctgggagccc tcacagccct 720
gggcagctac aatcgcttca acaacaactg ctacaaggac gccatcatcc tcgcgctcat 780
caacagcggg accagcttct ttgctggctt tgtggtcttc tccatcctgg gcttcatggc 840
tgcagagcag ggcgtgcaca tctccaaggt cgcggaatca gggcctggcc tggccttcat 900
cgcctacccc cgggccgtca cgctgatgcc tgtggcccca ctctgggctg ccctgttctt 960
cttcatgctg ctgctgcttg gtctcgacag ccagtttgta ggtgtggaag gcttcatcac 1020
cggcctgctc gacctcctcc cggcctccta ctacttccgt ttccaaaggg agatctctgt 1080
ggccctatgc tgtgccctct gctttgtcat cgacctctcc atggtgaccg atggcgggat 1140
gtacgtcttc cagttgtttg actactactc agccagcggc acgaccctgc tctggcaggc 1200
cttctgggag tgcgtggtgg ttgcctgggt gtatggagcc gaccgcttca tggatgacgt 1260
tgcctgcatg attgggtacc gaccttgccc ctggatgaaa tggtgctggt ctttcttcac 1320
cccgctggtc tgcatgggca tcttcatctt caacgtggtg tactacaagc cgttggtcta 1380
caacaatacc tacgtgtacc cgtggtgggg cgaggccatg ggctgggcct tcgcactctc 1440
ctccatgctg tgtgtgcccc tacacctcct gggctgcctc ctcagggcca aggggaccgt 1500
ggctgagcgc tggcaacacc tgacgcagcc tgtctggggc ctccaccact tggagtacag 1560
agctcaggac tcggatgtca ggggcctgac caccctgacc ccagtgtccg agagcagcaa 1620
ggtggtggtg gtggagagcg tcatgtgaca ggcaccccag ctcacatcac cagctcaccc 1680
tcttgtagcc atagcagccc ctgctttagc ccccccccga cccattcagg gggcttgcct 1740
ttccctgaca cttttggggt ctgccggggt gggggggaga agcaccatga gtgcttataa 1800
ctaaaataac ttttttccat ttttaataaa acaccaaaaa tatcacaacc caccaaaaat 1860
agatgcctcc ccccttaacc aagc 1884
<210>176
<211>2127
<212>DNA
<213>马
<400>176
gccgccgccg cggtggagat gaaattccgg gctatgaagc gtggcgtccg tgttcctgtt 60
cgtggcgaga cgacgacggc gctgtacctg agcagcacgt accgctcggc cggggatggc 120
atgtggcaag cgctgacgct gctgttctcg ctgctgccct gcgcgctcgt gcagctcacg 180
ctcctcttcg tgcaccgcga cttcagccgc gaccgcccgc tcgtgctgct gctgcacctg 240
ctgcaactcg ggcccctctt caggtgtttt gaagttttct gcatctattg tcagtcaaac 300
cacgttgaag agccttatgt cagcatcatc aagaagcgac agatgccaag aaatggcctc 360
tcagaggaga ttgagaggga agtgggccaa gcagagggca agctgttcac ccaccgatct 420
gcattcagcc gggcatcggt gatccaggct ttcctcggct cagcccccca gctgaccctg 480
cagctctata taagcacctt gcaacggaaa gtcactatca caagatgttt ctttatggtc 540
ctgtctctgt tatccattgt gtatggagcc ttgcgctgca acatcctagc catcaagatc 600
aagtacgatg aataccttgt aaaagtcaag cctctggcct atgtttgtat cttcctctgg 660
aggagctttg agattgccac tcgagttgtg gtcctggtcc tctttacttc cgtcctgaag 720
gcctgggtgg tgatgatcat actcatcaac ttcctcagct tcttcttcta tccctggatc 780
ctcttctggt gtagtggctc cccgttccct gagaacatcg agaaggccct cagtcgcgtg 840
ggcaccacca tcgtgctgtg cttcctcacc ttcctctatg ctggtatcaa catgttctgc 900
tggtcagctg tgcagctgaa aatcaacaac cctgacctca tcagcaagtc ccagaactgg 960
taccagctac tggtgtacta catgctgaga ttcgttgaga acgccttcct cctcctcatg 1020
tggtatcttt acaagaccga catctatatg tatgtgtgtg cacctctgtt gattctgcag 1080
ttgctcattg ggtactgcac agccattctg ttcatgctcg tgttctatca gttcttccat 1140
ccttgcaaaa agctcttttc caccagtgtt tctgaaggcc ttcaggagtg gctaaggtgt 1200
gtttgctgtg actgcaggcg gcagaaatcc tgtgagtctg taggaaaggc agatcttagg 1260
tcacctgcgg acatagatga gacaccttct agcagtaaaa taagttctat gcccagcgag 1320
atcttgaatc ccaatgagtt ctgctctatt taataggacc tgagtctctt ggggcacaga 1380
tatatgtatt ctgggttgat ccctgttcct cacacaagtg atgagccctg cgcagttaac 1440
agagcaggaa gttagctctc aactctttgt gagttgctcc cctttagaga gcttttgggc 1500
atatgggaac tatggggaga agccagggaa acccctgagt gttgaagggg cagcctaagg 1560
caccaccatg cacagttgac catgttctcc cgggtgttac tggccttttc actgaaaaag 1620
catcgatgat atctgagttg ggctggttac atccatcagg taaaatgagg acagtggttt 1680
tcttcttttc tagttttctg gattgctggt ctgggtagcc taatgtttta ttatccctga 1740
gcatagtttc acccaagaac tgtcctgatc accaaagaag gttcctgggg tttcaccatc 1800
agcaacatca ttcctgtcag agttttccga gagggctgtt catgtttggt ttttaaatac 1860
agagatattc cattttcatc tcattagggc tctttgtaca taaccaactg tagccacctt 1920
ggcctgctat ctctaattgg ttcaaaagtc tagatttggg actattcccc aggacccatg 1980
gatgtaaaac tgaattctaa atttggttgt ggaagcccta gcattttagg aaagttgtgt 2040
tccttcaata tgttgaagaa attctgcatc aagaaggttg ttaaaacatt aaaattatat 2100
agacttttgt aagcagaatt cttctca 2127
<210>177
<211>791
<212>DNA
<213>马
<400>177
ggttcaaact cttctccgtg agggtggagg cgatcgagag gtcacgtgat gagcatcctg 60
ctgcccaaca tggcggagtt cgacaccatc tcggaactgg aggaggagga ggaagaagcg 120
gcaacgtcgt cgtcgtcgcc gtcgtcgtct tctgtatcgg ggcccgacga cgatgacgag 180
gaagatgagg aggaggagga ggaagaagag gaggaggagg aagaagaaga ggaggaggag 240
acgccgcccc cgcctcgggt agtgagcgag gagcatctgc ggagatatgc ccccgacccc 300
gtattggtgc ggggcgccgg ccacatcact gtgtttggct tgagcaacaa gtttgatact 360
gaatttccct cagttctaac agggaaggtg gccccagaag aatttaagac cagcattggc 420
cgtgtgaatg catgtttgaa aaaggctctc ccagtcaatg tgaaatggtt gctgtgtggt 480
tgtctctgct gctgttgcac actgggttgc agcctgtggc ctgttgtttg tctcaacaaa 540
agaaccagaa gatcaattca gaagttatta gaatgggaaa ataacagatt atatcacaag 600
cttgctttgc actggaagtt gactaaaagg aaatgcgaaa ctagcaatat gatggagtat 660
gtaatactaa tagagttctt accaaaatat cccatattcc gacctgactg aggaatttta 720
ttcggtcact tctgtgttac ctgtcatttc ctacccttag tgccttgtag atgattttgg 780
aatgaagatg g 791
<210>178
<211>4621
<212>DNA
<213>马
<400>178
aggaatgtaa agaaagcaaa atggatccaa gtgtggatgt gaattctgtc accatctctg 60
ttgaggggat gacgtgtagt tcctgtgttt ggacgattga gcagcagatt ggaaaactga 120
gtggtgtcca tcacattaaa gtttcactgg aagaaaaatg tgcaactatt atttatgacc 180
ctaaactaca gactccaaag accctacagg aagctattga tgatatgggc tttgatgcca 240
ttctcaacca tcctaaccct ctgcctgttt taactgacac cgtgtttctc actgttactg 300
cttcactgtc tccaccatgg gaccatatcc aaagtacatt gctcaagacc aagggtgtga 360
cagacattaa aatttcccct cagcaaagaa ctgcagtggt gacaataatc ccttctgtag 420
tgactgccaa tcagataata gagctggttc cagatctcag tttagatatt ggaactctgg 480
agaaaaagtc aggaacttgt gaagattaca gtatggctca agcaggtgaa gtcatggtga 540
agatgaaagt ggaagggatg acctgccatt cctgcactag cacgattgaa ggaaaaattg 600
ggaaactgca aggtgttcag cgaattaaag tctccctgga caaccaagaa gctactattg 660
tttatcaacc tcatcttatc acagtcgagg aaatcaaaaa gcagatcgaa gctgcgggct 720
ttccagcatt catcaaaaaa cagcccaagt tcctcaaatt gggagctatt gatatagaac 780
gtctcaagaa cacaccagtc aaatcctcag aaagaccaca gcaaaggagt ccatcatgta 840
ccaatgattc agcagtcact ttcatcgtag atggcatgca ttgtaaatca tgtgtgtcaa 900
atattgaaag tgctttatct acactccaat atgtaagcag cgtagtagtt tctttagaga 960
ataggtctgc catagtaaag tacaatgcaa gcttagtcac tccagaaacc ctgagaaaag 1020
caatagaggc tatatcaccg gggcaatata gagtcagctt tccaagtgaa gttgagagta 1080
cctcaaactc tccctccggc tcctctcttc acaagattcc tttgaacata gttagccagc 1140
ctctcactca agaaaccgtg ataaacattg atggcatgac ttgtaattct tgtgtgcagt 1200
ctattgaggg tgtcatatca aaaaaggcag gtgtgaaatc catacgagta tcccttgcaa 1260
atggcaatgg gactgttgaa tatgatcctc tactaacctc tccagaaact ttgagaaaag 1320
caatagaaga catgggattt gatgctactt tgtcagatac aaatgagccg ttggtagtaa 1380
tagctcagcc ctcttcagaa gtgccacttt tgacctcaac taatgaattt tgtcctaaaa 1440
cgatgacacc aacgcacgac aaggaggagg caaagacttc atctaagtgt tacatacagg 1500
tcactggtat gacttgtgct tcctgtgtag caaacattga gcggaattta agacgagaag 1560
aaggaatata ttctgtactt gtggctctga tggctggcaa ggcagaagta agatataatc 1620
ctgctgtcat acaaccccca attatagctg agttcatccg agaacttggg tttggagcca 1680
ctgtaataga aaatgctgat ggcggagatg gcattttgga acttgttgtg agaggaatga 1740
catgtgcctc ctgtgtacat aaaatagagt ctaccctcac aaaacacaga gggatcttct 1800
actgctctgt ggccctggca accaacaaag cacatattaa atacgatcca gaaattattg 1860
gtcccagaga tattatccat acaattgaaa gcttaggttt taaagcttct ttggtcaaga 1920
aggatcggtc agcaagccac ctagaccata aacgagaaat aagacaatgg agacggtcct 1980
tccttgtgag cctatttttc tgtattcctg taatggggct gatgatatat atgatggtta 2040
tggaccacca ccttgaaact cttcaccata atcagaacat aagtcaagaa gaaatgatcc 2100
acattcattc ttctatgttc ctggagcgcc agatcctgcc aggattgtcc attatgaatt 2160
tgctatcctt tttattgtgt gtacctccaa aggaattttt cggaggctgg cacttctaca 2220
ttcaggccta caaagcactg aagcataaaa ctgcgaatat ggacgtgctg attgtgctgg 2280
ccaccaccat tgcatttgcc tactctttgg ttattcttct ggttgcaatg tatgagagag 2340
ccaaagtgaa ccctattact ttctttgaca cgcctcctat gctttttgtg tttattgcac 2400
taggccggtg gctggaacat atagcaaagg gcaaaacctc agaggctctt gccaagctaa 2460
tttcactaca agctacagaa gcaactattg taactcttga ctctgataat atcctcttga 2520
gtgaagaaca agtggatgtg gaacttgtac aacgtggaga catcattaaa gtggttccag 2580
gaggcaaatt tccagtggat ggtcgtgtta ttgaaggaca ttctatggta gatgagtctc 2640
tcatcacagg ggaggcaatg cctgtggcca agaaacctgg cagcacagta attgctggtt 2700
ccattaacca gaatgggtca ctacttatcc gtgcaaccca cgttggagga gacacaaccc 2760
tttctcaaat tgtcaaactt gtggaggagg cgcaaacatc caaggctcct atccagcagt 2820
ttgcagacaa actcagtggc tactttgttc cttttattgt tattgtttcc attgctaccc 2880
tcttggtttg gattataatt ggatttctga attttgaaat tgtggaagcc tactttcctg 2940
gctacaacag aagtatctcc cgaacagaaa caatagtacg ctttgctttc caagcctcta 3000
tcacggttct gtgcattgca tgcccttgtt cactgggact ggccactcca actgctgtga 3060
tggtgggtac aggagtaggt gctcaaaatg gcatcctaat caaaggtgga gagccactgg 3120
agatggctca taaggtaaag gtagtggtat ttgataagac tggaaccatt acccatggaa 3180
ccccagtagt gaatcaagta aaggttctag tggaaagtaa cagaatgtca cgcaataaga 3240
tcctggctat tgtgggaact gctgaaagta acagcgaaca ccctctagga gcagccataa 3300
cgaaatactg caagaaggag ctgaacactg aaaccttggg tacctgcaca gatttccagg 3360
ttgtgccagg ctgtggtatt agctgcaaag tcaccaatat tgaaggattc ctgcataaga 3420
ataactggaa gatagaggaa aataatatta aaaatgcatc cctggttcaa attgatgcaa 3480
gtaatgaaca gccatccact tcatcttcca taattattga tgcccagctc tcaaattctc 3540
ttaattctca gcagtacaaa gtcctcattg gtaaccggga gtggatgatt agaaatggtc 3600
ttgtcattaa caacgatgta gatgattcta tgaatgaaca tgagagaaaa ggtcgtactg 3660
ctgtattggt ggcagttgac gacgagctgt gtggcttgat agctattgct gatacagtga 3720
agcctgaagc agaattggct gtccatactc tgaaatcgat gggcttagaa gtagttctga 3780
tgactggaga caacagtaaa acagctcggt ctattgcttc tcaggttggc attactaagg 3840
tgtttgctga agttctacct tcccacaagg ttgctaaggt gaagcaactt caagaggagg 3900
ggaaacaggt agcaatggta ggagatggaa tcaatgactc cccagctctg gcgatggcta 3960
atgttggaat tgccattggc acaggcacag atgtagccat tgaagcagcc gatgtggttt 4020
tgataaggaa tgatcttctg gatgtagtgg caagtattga cttatcaagg aagacagtca 4080
agaggattcg gataaatttt gtcttcgctc taatttataa tctggttgga attcccatag 4140
ctgctggagt ttttatgccc attggtttgg ttttgcagcc ctggatggga tctgctgcaa 4200
tggctgcctc gtctgtttca gtagtacttt cttccctctt cctgaaactt tataggaaac 4260
caacttatga gaattacgaa ctgcatgccc gaagccagat gggacagaaa agtccttcag 4320
aaatcagcgt tcatgttgga atagatgaca cctcaagaaa ttctcctaaa ctgggtttgc 4380
tggaccggat tgttaattac agcagagcct ccataaactc actactgtct gataaacggt 4440
ccctaaacag catcggtacc agtgaacctg acaagcactc actcctggtg ggagactgca 4500
gggaagatga cgacactgcg ttgtaacagg ccacaaagag tgctactagc tgatgttatt 4560
atgcactgac acagcattca taatgtcacc ttagcttttc agaatattgc aagaggatgt 4620
t 4621
<210>179
<211>1146
<212>DNA
<213>马
<400>179
atggtgttcg cgttttggaa ggtctttctg atcctaaact gccttgcagg tcaagttact 60
gcggtgcaag tgaccatccc agacagtttc gtgaacgtga ctgttggatc tgatgtcact 120
ctcatctgca cctataccac cactgtggcc tctcgggaca agctttccat ccagtggtca 180
ttcttccaca agaaggagtt acagccagtt tccatttact attctgaagg tggacaagct 240
gcagccattg ggcaatttaa aggtcgaatt gtagggtcca acgaaccagg caacgcatct 300
atcactattt cgcatatgca accagcagat agtggcatct acatctgtga tgttaacaac 360
ccccctgact ttgtcggcac aaatcaaggc atcctcaacg tcagcgtgtt agtcaaacct 420
tctaagccct tttgcagcat ccagggaata ccagaaactg gccatcctat atctctttct 480
tgtctctccg tgcttggaac accttcccct gtgtactact ggtatagact tgaaggaaga 540
gacatcgtcc cagtgaaaga aagcttcaac ccagccactg gaattttagt cattggaaat 600
ctgaccaatt ttgaacaagg ttattaccag tgcactgcta tcaacatcct tggcaatagt 660
tcctgtgaaa ttgatctaac ttcttcacat ccagaagttg gaatcattgt tggggccttg 720
gtgggtaccc ttgtaggtgc tgccattatc acctctattg tgtgcttcgc aaggagcaag 780
gcaaaggcaa agggaaaggg gaaggagagg aagagaaatt ctaaaaccaa cccagaactt 840
gaaccaatga gaatgataaa ccaaagcaca gagtgtgaaa caatgccaaa tgaagatgct 900
gtccaactag aagcgactct gccagtttcc acccatgaga ctgaccctga taccatcctg 960
gggctggatc atgagcctat ccctgagcct gagcctgtcc cagagcctgt cccggagcct 1020
accgcaggac ctgagcttgt ccctgtgcct gagattgaga tccatctgga gccagagccg 1080
gagccggagc cagagacgga gccggagccc gggattgtag ttgaaccctt ttgtgacgag 1140
gaaaag 1146
<210>180
<211>1146
<212>DNA
<213>马
<400>180
agcccgagcg cgtcaccccc tcgcgctgcg gtggtcgcgt tccgctggcc cgttcggtgt 60
cggcctacgc tgctgcgacg ccgcggaaca atggctgtgc tcgtcgtgct cctctccctg 120
ctggtggcgg gtgttttggg aaatgagttt agtatattaa aatcaccagg gtctgttgtt 180
ttccgagatg gaaattggcc tataccagga gagcgaatcc cagacgtggc tgcactgtcc 240
atgggcttct ctgtgaaaga agacctttct tggcctggac ttgcggtggg taacctcttc 300
catcgtcctc gggctaccgt tatggtgatg gtgaagggag tggacaaact cgctctaccc 360
ccaggcagtg tcatttcgta ccctttggag aatgcagttc cttttagcct tgacagcgtt 420
gcaaattcca ttcactcctt attttctgaa gaaactcctg tagttttgca gttggctcct 480
agtgaggaac gagtgtatat ggtggggaag gcaaactcag tttttgaaga cctttcagta 540
accttacgac agcttcgcaa tcgcctgttt caagaaaatt ccattctcaa ttcacttccc 600
ctcaattctc tgagtaggaa caatgaagtt gacctgctct ttctttctga actgcaagtg 660
ctacatgata tttcaagttt gttgtctcga cataagcatc tagccaagga tcattctcct 720
gatttgtatt cactggagct ggcaggtttg gatgaaattg gaaaacatta cggggaagac 780
tctgaacaat tcagagatgc ttctaagatc cttgttgatg ctctgcaaaa gtttgcagat 840
gacatgtaca atctttacgg tgggaatgca gtggtagagt tagtgactat caaatcattc 900
gacacgtctg ttgtgaggaa gacaaggact atccttgagg cagaacaggc gaagagccca 960
tcaagtccct ataaccttgc atataagtat aatttagagt atccagtggt tttcaacatg 1020
gtactttgga taatgatcgc cttggccttg gctgtgatta tcacctctta caatatttgg 1080
aacatggatc ctggatatga tagcatcatt tataggatga caaaccagaa gattcgaatg 1140
gattga 1146
<210>181
<211>3762
<212>DNA
<213>马
<400>181
acaggcagga tgggcgacat ggccaacagt tccattgagt tccaccccaa gccccagcag 60
caacgggaag cgccccatgc aggcggcttt gggtgcacac tggctgagct gcgctccctc 120
atggagctcc gaggggccga ggcgctgcag aaggtccagg aagcctatgg ggatgtcagc 180
gggctctgca ggaggctgaa gacctcgccc acagagggtc tggccgacaa tgccagtgac 240
ttggagaagc gcaggcagat ctacgggcag aacttcatcc ctcccaagca gcccaagacc 300
ttcctgcagc tggtgtggga ggccctgcag gacgtgaccc tcatcatcct agaggtggct 360
gccatcgtct ccctgggcct ctcgttctat gcgccacccg gagaggagag tgaggcgtgc 420
gggaatgtgt cagccggggc agaagatgaa ggcgaggctg aggccggttg gatcgagggg 480
gccgccatcc tgctgtctgt agtctgcgtg gtgctggtca cagctttcaa tgactggagc 540
aaggagaagc agttccgggg cctgcagagc cgcatcgagc aggagcagaa gttcacagtc 600
atccgcaatg ggcagctcct ccaggtccct gtggccgcac tggtggtggg cgacatcgcc 660
caggtcaagt atggagacct gctgcctgcc gacggcgtgc tcatccaggg caacgacctc 720
aagatcgatg agagctccct gactggcgag tcggaccacg tgcgcaagtc agccgacaaa 780
gaccccatgc tgctctcagg tactcacgtc atggaaggtt ccggaagaat ggtggtgacg 840
gccgtcggtg tgaactccca gacaggcatc atcttcacct tgctcggagc aggcggagag 900
gaggaggaga agaaggataa gaagggtaag ggaaagcaat gcaagcagca ggatggggcg 960
atggagagta gccagaccaa agctaagaag caggatgggg cggttgccat ggaaatgcag 1020
cctctgaaga gcgcggaggg cggggagatg gaagagcggg agaagaagaa agccaccgtg 1080
cccaagaagg agaaatccgt ccttcagggc aagctcacca aactggctgt gcagatcggg 1140
aaagcagggc tggtgatgtc tgccatcacc gtcatcatcc tggtcctcta ctttgtgatt 1200
gagaccttcg tcgtcgacgg ccgggtgtgg cttgcggagt gcacgccagt ctatgtgcag 1260
tacttcgtga agttcttcat catcggtgtc actgtgctgg tcgtggctgt cccggagggc 1320
ctccctcttg ctgtcaccat ctccttagct tactctgtca agaaaatgat gagggacaac 1380
aacctggtcc gccacctgga cgcctgcgag accatgggca atgccacggc catctgctcg 1440
gacaagacgg gcacactcac caccaaccgt atgaccgtgg tccagtccta cctcggggac 1500
actcactaca aggagattcc agcccccagc gccctgacac ccaagatcct cgacctcctg 1560
gtccacgcca tctccatcaa cagtgcctac accaccaaaa tactacctcc agagaaggaa 1620
ggggctctcc cacgccaagt gggcaacaag acggagtgtg ccctgctggg cttcgtcctg 1680
gacctgaagc gggacttcca gcctgtgcga gagcagattc cggaagataa gctttacaaa 1740
gtgtacacct tcaactcagt ccgcaagtcc atgagcacag tcatccgcac gcccgacggc 1800
ggcttccgcc tcttcagcaa gggcgcctcg gagatcctgc tgaaaaagtg caccaacatc 1860
ttaaacagca acggagaact gcgcagcttc cgccctcggg accgggacga catggtgaag 1920
aagatcattg agccgatggc ttgcgacggc ctccgcacca tctgcatcgc ctaccgcgac 1980
ttctctgctg cccaggagcc tgactgggac aatgagaatg aggtggtggg cgacctcacc 2040
tgcatagctg tcgtgggcat cgaggaccct gtgcgacccg aggtccctga agctatccgc 2100
aaatgccaac gtgctggcat tacagtccgc atggtgactg gagacaacat caacacggcc 2160
cgggccatcg cagccaagtg tggcatcatc cagccagggg aggacttcct gtgcctggag 2220
ggaaaagaat tcaaccggcg catccgcaat gagaaaggcg agatagaaca ggagcgtctg 2280
gacaaggtgt ggcccaagct gagggtcctc gcccgatcat ctcccactga caagcacact 2340
ctggtcaaag ggattattga cagcacgact ggcgagcagc gacaggtggt ggccgtgacg 2400
ggggatggca ctaacgacgg gccagccctc aagaaagcag atgtgggctt cgccatgggc 2460
atcgcaggga ctgacgtggc caaggaggcc tcggacatca tcctgaccga tgacaacttc 2520
accagcatcg tcaaggcggt catgtggggc cgcaacgtgt acgacagcat ctcaaagttc 2580
ctgcagttcc agctgacagt caacgtggtg gccgtgattg tggccttcac gggcgcctgc 2640
attactcagg actctcctct caaagccgtg cagatgttgt gggtgaactt gatcatggac 2700
acatttgcct ctctggccct ggcgacggag ccccccaccg aatcgctgct gctgcggaag 2760
ccatacggcc gagacaagcc cctgatctcc cgcaccatga tgaagaacat actaggccac 2820
gcggtgtacc agctcaccat catcttcacg ctgctctttg tgggggagct cttcttcgac 2880
attgacagtg ggaggaacgc gcccctgcac tcgccgccct cggagcacta caccatcatc 2940
ttcaacacct tcgtcatgat gcagctcttc aacgaggtca acgcccgcaa gatccacggc 3000
gagcgcaacg tgttccacgg catcttcagc aaccccatct tctgcgccat cgtcctgggc 3060
acctttgcaa ttcagattgt catcgtccag tttggcggga agcccttcag ctgctccccc 3120
ctgtccacgg agcagtggct ctggtgcctg tttgttggcg ttggggagct ggtctgggga 3180
caggtcattg ccaccatccc caccagccag ctcaagtgcc tgaaggaagc agggcatggg 3240
cccgggaagg atgagatggc tgacgaggag ctggccgagg gagaggaaga gattgaccat 3300
gctgagcgcg agctccgccg aggccagatc ctctggttcc ggggcctcaa ccggatccag 3360
acacagatgg aggtagtgag taccttcaag agaagcggtt catttcaggg tgctgtgcgc 3420
cggcggtctt cggtcctcag ccagctccat gacatccggg tggtgaaagc attccgtagc 3480
tcactctatg aaggcctgga gaaaccggaa tccaagacct ccatccataa cttcatggca 3540
acgcccgagt ttctgatcaa tgactacacc cacaacatcc cgctcatcga tgacacggac 3600
gtggacgaga acgaggaccg tctgcgggcc cccccacctc cgtcccccaa ccagaacaac 3660
aacgccatag acagcggcat ctacctgacc acgcacggca ccaagtcagc tacctcgtca 3720
gtacccggga gcccgctcca cagcgtggag acgtccctct aa 3762
<210>182
<211>1193
<212>DNA
<213>马
<400>182
ccaaccacaa gcactaaagc agaggggcag gcagcacgca gcctggcagc cagcgcacca 60
gcccagccat ggtccttgag gtaagtgaac atcaagtgtt ccaagactct gagcttgcct 120
tcctcctgga aaactgcagc tcttcctatg actacctagg agaaaatgag agtgacacct 180
gctgcgcgtc cccaccctgc ccacaggact tcagcctgaa ctttgacagg gccttcctgc 240
cggccctcta cggcctcctc tttgtgctgg ggctgctggg caacggcgct gtggcggccg 300
tgctgctgag ccagcgggcc gccctgagca gcaccgacac tttcctgctc cacctggccg 360
tggctgacgc actgctggtg ctgaccctcc cgctctgggc agtggatgct gctgtccagt 420
gggtcttcgg ctctggcctc tgcaaagtgg caggtgccct cttcaacatc aacttctatg 480
caggggccct cctactggcc tgcatcagct ttgatcggta cctgagcata gtgcatgcca 540
cccaactcta ccgccggggg cccccgaccc gcgtggccct cacttgtgta gttgtctggg 600
ggctctgtct gctctttgcc ctcccagact tcatcttcct gtcagcccac cgtgacgagc 660
gcctcaatgc cacccactgc cagtacaact tcccgcaggt gggtcgcaca gctctgcgcg 720
tactgcagct ggttgctggt ttcctgctgc ccttgctggt catggcctac tgctatgccc 780
gcatcctggc tgtgctgctg gtctccagag gccagcggcg gctgcgagcc atgcgcctag 840
tggtggtggt agttgtggcc tttgccctct gctggacccc ctactacctg gtgatgctgg 900
tggacaccct catggacctg ggggccttgg cccgcaactg tggcagagaa agtcatgtgg 960
atgtggccaa gtctgtcacc tcaggtctag ggtatatgca ctgctgcctc aacccgctgc 1020
tctacgcctt tgtgggtgtc aagttccgag agcgtatgtg gatgctactt atgcgcctgg 1080
gctgccctga ccagaaaggg catcaacggc agccaccatc ttgccgccgg gattcatcct 1140
ggtctgagac cacagaggcc tcctactcag gcttgtgagg ctgggatggg ggc 1193
<210>183
<211>359
<212>PRT
<213>马
<400>183
Met Ala Thr Thr Leu Asp Gly Thr Glu Thr Val Gly Glu Ala Glu Gly
1 5 10 15
Thr Thr Pro Tyr Asp Tyr Asp Gly Ser Leu Pro Cys Glu Lys Ile Asn
20 25 30
Ile Lys Met Leu Ala Ala Gln Phe Leu Pro Pro Leu Tyr Ser Leu Val
35 40 45
Val Val Ile Gly Leu Leu Gly Asn Leu Met Val Val Val Ile Leu Thr
50 55 60
Lys Tyr Lys Arg Leu Arg Ile Met Thr Asn Ile Phe Leu Phe Asn Leu
65 70 75 80
Ala Ile Ser Asp Leu Leu Phe Leu Phe Thr Leu Pro Phe Trp Ile His
85 90 95
Tyr Val Trp Arg Asp Glu Trp Val Phe Gly His His Met Cys Lys Phe
100 105 110
Leu Ile Gly Leu Cys Tyr Thr Gly Leu Tyr Ser Glu Ile Phe Phe Ile
115 120 125
Ile Leu Leu Thr Leu Asp Arg Tyr Leu Ala Ile Val His Ala Val Phe
130 135 140
Ala Leu Arg Thr Arg Thr Val Thr Phe Gly Ile Ile Thr Ser Val Phe
145 150 155 160
Thr Trp Gly Leu Ala Gly Leu Ala Ala Leu Pro Glu Phe Ile Phe His
165 170 175
Gly Phe Gln Glu Glu Phe Gly Gln Tyr Val Cys Leu Pro Phe Tyr Pro
180 185 190
Glu Ala Ala Glu Asn Ile Trp Lys Ser Thr His Val Leu Arg Met Asn
195 200 205
Ile Leu Ser Leu Ala Leu Pro Leu Leu Ile Met Ala Val Cys Tyr Ser
210 215 220
Gly Ile Ile Lys Thr Leu Leu Arg Cys Pro Asn Lys Lys Lys Tyr Lys
225 230 235 240
Ala Ile Arg Leu Ile Phe Val Ile Met Val Val Phe Phe Val Phe Trp
245 250 255
Ala Pro Tyr Asn Leu Val Leu Phe Phe Ser Thr Phe Gln Thr Thr Phe
260 265 270
Leu Gly Thr Ser Cys Asp Gln Ser Lys Gln Leu Asp Met Ala Leu Leu
275 280 285
Val Thr Glu Met Ile Ala Tyr Thr His Cys Cys Val Asn Pro Val Ile
290 295 300
Tyr Ala Phe Val Gly Glu Arg Phe Gln Lys Asn Leu His His Phe Phe
305 310 315 320
His Thr Tyr Val Ala Ile Tyr Leu Cys Lys Tyr Ile Pro Phe Leu Pro
325 330 335
Ser Glu Lys Leu Glu Arg Ala Ser Ser Val Ser Pro Ser Thr Gly Glu
340 345 350
Gln Glu Leu Ser Ala Ala Phe
355
<210>184
<211>1231
<212>PRT
<213>马
<400>184
Glu Gly His His Val Met Glu Pro Pro Val Ile Thr Glu Gln Ser Pro
1 5 10 15
Arg Arg Leu Val Val Phe Pro Thr Asp Asp Ile Ser Leu Lys Cys Glu
20 25 30
Ala Ser Gly Lys Pro Glu Val Glu Phe Arg Trp Thr His Asp Gly Val
35 40 45
His Phe Lys Pro Lys Glu Glu Leu Gly Val Thr Val His Gln Glu Pro
50 55 60
His Ser Gly Ser Phe Thr Ile Thr Gly Asn Asn Ser Asn Phe Ala Gln
65 70 75 80
Arg Phe Gln Gly Thr Tyr Arg Cys Phe Ala Ser Asn Lys Leu Gly Thr
85 90 95
Ala Met Ser His Glu Ile Gln Leu Met Ala Glu Gly Ala Pro Lys Trp
100 105 110
Pro Lys Glu Thr Val Lys Pro Val Glu Val Glu Glu Gly Glu Ser Val
115 120 125
Ile Leu Pro Cys His Pro Pro Pro Ser Ala Glu Pro Leu Arg Ile Tyr
130 135 140
Trp Met Asn Ser Lys Ile Leu His Ile Lys Gln Asp Glu Arg Val Thr
145 150 155 160
Met Gly Gln Asn Gly Asn Leu Tyr Phe Ala Asn Val Leu Thr Ser Asp
165 170 175
Asn His Ser Asp Tyr Ile Cys Asn Ala His Phe Pro Gly Thr Arg Thr
180 185 190
Ile Ile Gln Lys Glu Pro Ile Asp Leu Arg Val Lys Ala Thr Asn Ser
195 200 205
Met Ile Ser Arg Lys Pro Arg Leu Leu Phe Pro Thr Asn Ser Ser Ser
210 215 220
His Leu Val Ala Leu Gln Gly Gln Pro Leu Ile Leu Glu Cys Ile Ala
225 230 235 240
Glu Gly Phe Pro Thr Pro Thr Ile Lys Trp Leu Arg Pro Ser Gly Pro
245 250 255
Met Pro Ser Asp Arg Val Thr Tyr Gln Asn His Asn Lys Thr Leu Gln
260 265 270
Leu Leu Asn Val Gly Glu Glu Asp Asp Gly Glu Tyr Arg Cys Leu Ala
275 280 285
Glu Asn Ser Leu Gly Ser Asp Arg His Ala Tyr Tyr Val Thr Val Glu
290 295 300
Ala Ala Pro Tyr Trp Leu Gln Lys Pro Gln Ser His Leu Tyr Gly Pro
305 310 315 320
Gly Glu Thr Val Arg Leu Asp Cys Gln Val Gln Gly Arg Pro Gln Pro
325 330 335
Glu Val Thr Trp Arg Ile Asn Gly Ile Pro Val Glu Glu Leu Ala Lys
340 345 350
Asp Gln Lys Tyr Arg Ile Gln Arg Gly Ala Leu Ile Leu Ser Asn Ile
355 360 365
Gln Pro Ser Asp Thr Met Val Thr Gln Cys Glu Ala Arg Asn Arg His
370 375 380
Gly Val Leu Leu Ala Asn Ala Tyr Ile Tyr Val Val Gln Leu Pro Ala
385 390 395 400
Lys Ile Leu Thr Pro Asp Asn Glu Thr Tyr Met Ala Val Glu Gly Ser
405 410 415
Thr Ala Tyr Leu Leu Cys Lys Ala Phe Gly Ala Pro Val Pro Ser Val
420 425 430
Gln Trp Leu Asp Lys Glu Gly Lys Thr Val Leu Gln Asp Glu Arg Phe
435 440 445
Phe Pro Tyr Thr Asp Gly Thr Leu Gly Ile Arg Asp Leu Gln Ala Asn
450 455 460
Asp Thr Gly His Tyr Phe Cys Gln Ala Ala Asn Asp Gln Asn Asn Val
465 470 475 480
Thr Ile Val Ala Asn Leu Gln Val Lys Asp Ala Thr Gln Ile Thr Gln
485 490 495
Gly Pro Arg Ser Ala Ile Glu Lys Lys Gly Ser Arg Val Thr Phe Thr
500 505 510
Cys Gln Ala Ser Phe Asp Pro Ser Leu Glu His Ser Ile Thr Trp Arg
515 520 525
Gly Asp Gly His Asn Leu Gln Glu Leu Gly Asp Ser Asp Lys Tyr Ile
530 535 540
Ile Glu Asp Gly Arg Leu Val Ile His Ser Leu Asp Tyr Ser Asp Gln
545 550 555 560
Gly Asn Tyr Ser Cys Val Ala Gly Thr Lys Leu Asp Val Val Glu Ser
565 570 575
Arg Ala Glu Leu Leu Val Val Gly Asp Pro Gly Pro Val Pro Gln Leu
580 585 590
Glu Leu Ser Asp His His Leu Leu Lys Gln Ser Gln Val Arg Leu Ser
595 600 605
Trp Ser Pro Ala Asp Asp His Asn Ala Pro Ile Glu Lys Tyr Asp Ile
610 615 620
Glu Phe Glu Asp Lys Glu Met Ala Pro Glu Lys Trp Tyr Ser Leu Gly
625 630 635 640
Lys Val Pro Gly Asn Gln Thr Ser Thr Thr Leu Lys Leu Ser Pro Tyr
645 650 655
Val His Tyr Thr Phe Arg Val Thr Ala Ile Asn Lys Tyr Gly Pro Gly
660 665 670
Glu Pro Ser Pro Ala Ser Glu Thr Val Val Thr Pro Glu Ala Ala Pro
675 680 685
Glu Lys Asn Pro Val Asp Val Lys Gly Glu Gly Asn Glu Thr Asn Asn
690 695 700
Met Val Val Thr Trp Lys Pro Leu Lys Trp Met Asp Trp Asn Ala Pro
705 710 715 720
Gln Val Gln Tyr Arg Val Gln Trp Arg Pro Gln Gly Thr Arg Gly Thr
725 730 735
Trp Gln Glu Gln Ile Val Ser Asp Pro Phe Leu Val Val Ser Asn Thr
740 745 750
Ser Thr Phe Val Pro Tyr Glu Ile Lys Val Gln Ala Val Asn Ser Gln
755 760 765
Gly Lys Gly Pro Glu Pro Pro Ile Thr Ile Gly Tyr Ser Gly Glu Asp
770 775 780
Tyr Pro Gln Ala Ser Pro Glu Leu Glu Gly Ile Lys Ile Leu Asn Ser
785 790 795 800
Ser Thr Val Leu Val Arg Trp Trp Pro Val Asp Pro Ala Leu Val Lys
805 810 815
Gly His Leu Arg Gly Tyr Asn Val Thr Tyr Trp Trp Glu Gly Ser Gln
820 825 830
Arg Lys His Ser Lys Arg His Val His Lys Gly His Met Val Val Pro
835 840 845
Ala Asn Ala Thr Ser Ala Ile Leu Gly Gly Leu Arg Pro Tyr Ser Phe
850 855 860
Tyr His Leu Glu Val Gln Ala Phe Asn Gly Arg Gly Leu Gly Pro Ala
865 870 875 880
Ser Glu Met Thr Phe His Thr Pro Glu Gly Val Pro Gly His Pro Glu
885 890 895
Ala Leu His Leu Glu Cys Gln Ser Asn Thr Ser Leu Leu Leu His Trp
900 905 910
Gln Pro Pro Leu Ser His Asn Gly Val Leu Thr Gly Tyr Val Leu Ser
915 920 925
Tyr His Pro Leu Asp Asn Gly Gly Lys Glu Gln Leu Ser Phe Asp Leu
930 935 940
Pro Asp Pro Glu Leu Arg Ser His Asn Leu Ser Asn Leu Ser Pro Gln
945 950 955 960
Leu Arg Tyr Arg Phe Gln Leu Gln Ala Thr Thr Lys Glu Gly Pro Gly
965 970 975
Glu Ala Ile Val Arg Glu Gly Gly Thr Met Ala Leu Ala Gly Asn Arg
980 985 990
Ser Phe Gly Asn Ile Ser Ala Met Ala Gly Glu Asn Tyr Ser Val Val
995 1000 1005
Ser Trp Val Pro Arg Glu Gly Arg Cys Asn Phe Gly Phe Gln Ile Trp
1010 1015 1020
Phe Lys Ala Leu Gly Asp Glu Lys Met Gly Ala Arg Leu Thr Pro Gln
1025 1030 1035 1040
Ser Val Ser Tyr Asn Gln Ser Ser Tyr Thr Gln Trp Asp Leu Gln Pro
1045 1050 1055
Asp Thr His Tyr Glu Ile His Leu Leu Lys Glu Thr Val Leu Leu His
1060 1065 1070
Gln Met Ala Val Lys Thr Asn Gly Thr Ser His Val Arg Leu Pro Pro
1075 1080 1085
Ala Gly Phe Thr Thr Glu Gly Trp Phe Ile Gly Phe Val Ser Ala Ala
1090 1095 1100
Val Leu Leu Leu Leu Val Leu Leu Ile Leu Cys Phe Ile Lys Arg Ser
1105 1110 1115 1120
Lys Gly Gly Lys Tyr Ser Val Lys Asp Lys Glu Asp Thr Gln Val Asp
1125 1130 1135
Ser Glu Ala Arg Pro Met Lys Asp Glu Thr Phe Gly Glu Tyr Arg Ser
1140 1145 1150
Leu Glu Ser Asp Asn Glu Glu Lys Ala Phe Gly Ser Ser Gln Pro Ser
1155 1160 1165
Leu Asn Gly Asp Ile Lys Pro Leu Gly Ser Asp Asp Se r Leu Ala Asp
1170 1175 1180
Tyr Gly Gly Ser Val Asp Val Gln Phe Asn Glu Asp Gly Ser Phe Ile
1185 1190 1195 1200
Gly Gln Tyr Ser Gly Lys Lys Glu Lys Glu Ala Thr Gly Gly Asn Asp
1205 1210 1215
Ser Ser Gly Ala Ala Ser Pro Ile Asn Pro Ala Gly Thr Leu Glu
1220 1225 1230
<210>185
<211>356
<212>PRT
<213>马
<400>185
Met Pro Thr His Phe Pro Glu Pro Ile Ser Asp Asp Phe Gln Tyr Asp
1 5 10 15
Glu Ser Ala Glu Ala Cys Asn Met Glu Asp Ile Val Val Phe Gly Thr
20 25 30
Ala Phe Leu Ser Val Val Tyr Ser Leu Val Phe Val Phe Gly Leu Val
35 40 45
Gly Asn Leu Leu Val Ile Phe Ser Leu Ser Asn Ser Arg Lys Arg Lys
50 55 60
Ser Ile Thr Asp Ile Tyr Leu Leu Asn Leu Ala Leu Ser Asp Leu Leu
65 70 75 80
Phe Val Ala Thr Leu Pro Phe Trp Thr His Tyr Leu Arg Ser Glu Gln
85 90 95
Gly Phe His Asn Ala Val Cys Lys Leu Thr Thr Ala Phe Phe Phe Ile
100 105 110
Gly Phe Phe Gly Gly Ile Phe Phe Ile Thr Ile Ile Ser Ile Asp Arg
115 120 125
Tyr Leu Ala Ile Val Leu Ala Ala Asn Ser Met Asn Asn Arg Thr Val
130 135 140
Thr His Gly Val Thr Ile Ser Leu Gly Val Trp Ala Ala Ala Ile Leu
145 150 155 160
Val Ala Ala Pro Gln Phe Met Phe Thr Lys Gln Lys Glu Asn Glu Cys
165 170 175
Leu Gly Asp Tyr Pro Glu Val Leu Gln Asp Ile Trp Pro Val Leu Arg
180 185 190
Asn Val Glu Ala Asn Ala Leu Gly Phe Leu Leu Pro Leu Leu Ile Leu
195 200 205
Ile Tyr Cys Tyr Phe Arg Ile Met A rg Thr Leu Phe Ser Cys Lys Asn
210 215 220
Arg Lys Lys Ala Lys Ala Ile Lys Leu Ile Leu Leu Val Val Ile Val
225 230 235 240
Phe Phe Leu Phe Trp Thr Pro Tyr Asn Ile Met Ile Phe Leu Glu Thr
245 250 255
Leu Asn Leu Tyr Asp Phe Phe Pro Asp Cys Asp Met Lys Arg Asp Leu
260 265 270
Lys Leu Ala Ile Gly Val Thr Glu Thr Ile Ala Phe Ile His Cys Cys
275 280 285
Leu Asn Pro Ile Ile Tyr Ala Phe Ala Gly Glu Lys Phe Arg Arg Tyr
290 295 300
Leu Ser His Leu Tyr Arg Lys Cys Leu Ala Val Leu Cys Cys Tyr Ser
305 310 315 320
Val Asp Thr Gly Phe Ser Pro Pro Glu Ser Gln Thr Gly Arg Arg Glu
325 330 335
Ser Ile Leu Ser Ser Asn Phe Thr His Tyr Thr Ser Asp Gly Glu Val
340 345 350
Ser Leu His Val
355
<210>186
<211>193
<212>PRT
<213>马
<400>186
Val Gly Trp Ile Leu Ser Thr Ile Cys Met Gly Phe Ala Glu Trp Arg
1 5 10 15
Val Trp Tyr Met Asn Asn Thr Ser Leu Leu Pro Ser Gly Leu Ala Arg
20 25 30
Val Gly Met Trp Lys Ile Cys Ile Tyr Tyr His Ala Asp Asn Phe Tyr
35 40 45
Arg Ala Thr Ser Cys Tyr His Tyr Thr Tyr Cys Asp Thr Phe Leu Pro
50 55 60
Leu Asp Ile Arg Ile Ala Gln Asn Leu Leu Leu Ile Ala Ser Ile Leu
65 70 75 80
Gly Leu Leu Gly Lys Ala Ser Ile Thr Phe Ala Leu Arg Asn Val Tyr
85 90 95
Met Gly Ile Leu Arg Lys Asn Ala Thr Cys Asn Ala Phe Val Ala Ser
100 105 110
Gly Ile Leu Asn Ile Ala Ala Gly Val Cys Ile Ser Val Ala Val Thr
115 120 125
Trp Asn Tyr His Ser Val Met Asn Glu Glu Glu Ile Ala Phe Pro Pro
130 135 140
Tyr Phe Tyr Val Pro Phe Lys Pro Asp Ala Gln Glu Ile Gly Asn Ala
145 150 155 160
Ile Ile Val Ala Cys Leu Ala Ala Phe Leu Met Leu Leu Ser Gly Leu
165 170 175
Cys Phe Leu Ser Tyr Lys Phe Pro Leu Asp Ser His Val Cys Pro Glu
180 185 190
Ile
<210>187
<211>1135
<212>PRT
<213>马
<400>187
Met Leu Val Gly Arg Trp Ser His Leu Tyr Pro Arg Thr Cys Gln Cys
1 5 10 15
Ala Gly Glu Glu Lys Arg Val Gly Thr Arg Thr Val Phe Val Gly His
20 25 30
His Pro Val Ser Glu Thr Glu Thr Tyr Val Ala Gln Lys Phe Cys Asp
35 40 45
Asn Arg Ile Val Ser Ser Lys Tyr Thr Leu Trp Asn Phe Leu Pro Lys
50 55 60
Asn Leu Phe Glu Gln Phe Arg Arg Ile Ala Asn Phe Tyr Phe Leu Ile
65 70 75 80
Ile Phe Leu Val Gln Val Thr Val Asp Thr Pro Thr Ser Pro Val Thr
85 90 95
Ser Gly Leu Pro Leu Phe Phe Val Ile Thr Val Thr Ala Ile Lys Gln
100 105 110
Gly Tyr Glu Asp Trp Leu Arg His Arg Ala Asp Asn Glu Val Asn Lys
115 120 125
Arg Thr Val Tyr Ile Ile Glu Asn Ala Lys Arg Val Arg Lys Glu Ser
130 135 140
Glu Lys Ile Lys Val Gly Asp Val Val Glu Val Gln Ala Asp Glu Thr
145 150 155 160
Phe Pro Cys Asp Leu Ile Leu Leu Ser Ser Cys Thr Ser Asp Gly Thr
165 170 175
Cys Tyr Val Thr Thr Ala Ser Leu Asp Gly Glu Ser Asn Cys Lys Thr
180 185 190
His Tyr Ala Val Arg Asp Thr Ile Ala Leu Cys Thr Ala Glu Ser Ile
195 200 205
Asp Thr Leu Arg Ala Ala Ile Glu Cys Glu Gln Pro Gln Pro Asp Leu
210 215 220
Tyr Lys Phe Val Gly Arg Ile Asn Ile Arg Asn Asn Asn Leu Glu Ala
225 230 235 240
Val Ala Arg Ser Leu Gly Pro Glu Asn Leu Leu Leu Lys Gly Ala Thr
245 250 255
Leu Lys Asn Thr Lys Lys Ile Tyr Gly Val Ala Val Tyr Thr Gly Met
260 265 270
Glu Thr Lys Met Ala Leu Asn Tyr Gln Gly Lys Ser Gln Lys Arg Ser
275 280 285
Ala Val Glu Lys Ser Ile Asn Ala Phe Leu Ile Val Tyr Leu Phe Ile
290 295 300
Leu Leu Thr Lys Ala Ala Val Cys Thr Thr Leu Lys Tyr Ile Trp Gln
305 310 315 320
Ser Ile Pro Tyr Asn Asp Glu Pro Trp Tyr Asn Gln Lys Thr Gln Lys
325 330 335
Glu Arg Glu Thr Phe Lys Val Leu Lys Met Phe Thr Asp Phe Leu Ser
340 345 350
Phe Met Val Leu Phe Asn Phe Ile Ile Pro Val Ser Met Tyr Val Thr
355 360 365
Val Glu Met Gln Lys Phe Leu Gly Ser Phe Phe Ile Ser Trp Asp Lys
370 375 380
Asp Phe Tyr Asp Glu Glu Ile Asn Glu Gly Ala Leu Val Asn Thr Ser
385 390 395 400
Asp Leu Asn Glu Glu Leu Gly Gln Val Asp Tyr Val Phe Thr Asp Lys
405 410 415
Thr Gly Thr Leu Thr Glu Asn Ser Met Glu Phe Val Glu Cys Cys Ile
420 425 430
Asp Gly His Lys Tyr Lys Gly Val Thr Gln Glu Ala Asp Gly Leu Ser
435 440 445
Gln Thr Asp Gly Pro Leu Thr Tyr Phe Asp Lys Ala Asp Lys Asn Arg
450 455 460
Glu Glu Leu Phe Leu Arg Ala Leu Ser Leu Cys His Thr Val Glu Ile
465 470 475 480
Lys Thr Asn Asp Ala Val Asp Gly Ala Pro Glu Ser Ser Glu Leu Ala
485 490 495
Tyr Met Ser Ser Ser Pro Asp Glu Ile Ala Leu Val Lys Gly Ala Lys
500 505 510
Lys Tyr Gly Phe Thr Phe Val Gly Ile His Asn Gly His Met Arg Val
515 520 525
Glu Asn Gln Arg Lys Glu Ile Glu Glu Tyr Glu Leu Leu His Thr Leu
530 535 540
Asn Phe Asp Pro Val Arg Arg Arg Met Ser Val Ile Val Lys Thr Gln
545 550 555 560
Ala Gly Asp Ile Leu Leu Phe Cys Lys Gly Ala Asp Ser Ala Val Phe
565 570 575
Pro Arg Val Gln Asn His Glu Ile Glu Leu Thr Lys Ala His Val Glu
580 585 590
Arg Asn Ala Val Asp Gly Tyr Arg Thr Leu Cys Val Ala Phe Lys Glu
595 600 605
Ile Ala Pro Asp Asp Tyr Glu Arg Ile Asp Arg Gln Leu Ile Glu Ala
610 615 620
Lys Met Ala Leu Gln Asp Arg Glu Glu Lys Mer Glu Lys Val Phe Asp
625 630 635 640
Asp Ile Glu Thr Asn Met Asn Leu Ile Gly Ala Thr Ala Val Glu Asp
645 650 655
Lys Leu Gln Asp Gln Ala Ala Glu Thr Ile Glu Ala Leu His Ala Ala
660 665 670
Gly Leu Lys Val Trp Val Leu Thr Gly Asp Lys Met Glu Thr Ala Lys
675 680 685
Ser Thr Cys Tyr Ala Cys Arg Leu Phe Gln Thr Asn Thr Glu Leu Leu
690 695 700
Glu Leu Thr Thr Lys Thr Ile Glu Glu Cys Glu Arg Lys Glu Asp Arg
705 710 715 720
Leu His Glu Leu Leu Ile Glu Tyr Cys Lys Lys Leu Arg His Glu Phe
725 730 735
Pro Lys Gly Ser Arg Asn Leu Lys Lys Ala Trp Thr Glu His Gln Glu
740 745 750
Tyr Gly Leu Ile Ile Asp Gly Ser Thr Leu Ser Leu Ile Leu Asn Ser
755 760 765
Ser Gln Asp Ser Ser Ser Asn Asn Tyr Lys Ser Val Phe Leu Gln Ile
770 775 780
Cys Met Lys Ser Thr Ala Val Leu Cys Ser Arg Met Ala Pro Leu Gln
785 790 795 800
Lys Ala Gln Ile Val Arg Met Val Lys Asn Leu Lys Gly Ser Pro Ile
805 810 815
Thr Leu Ser Ile Gly Asp Gly Ala Asn Asp Val Ser Met Ile Leu Glu
820 825 830
Ser His Val Gly Ile Gly Ile Lys Gly Lys Glu Gly Arg Gln Ala Ala
835 840 845
Arg Asn Ser Asp Tyr Ser Val Pro Lys Phe Lys His Leu Lys Lys Leu
850 855 860
Leu Leu Ala His Gly His Leu Tyr Tyr Val Arg Ile Ala His Leu Val
865 870 875 880
Gln Tyr Phe Phe Tyr Lys Asn Leu Cys Phe Ile Leu Pro Gln Phe Leu
885 890 895
Tyr Gln Phe Phe Cys Gly Phe Ser Gln Gln Pro Leu Tyr Asp Ala Ala
900 905 910
Tyr Leu Thr Met Tyr Asn Ile Cys Phe Thr Ser Leu Pro Ile Leu Ala
915 920 925
Tyr Ser Leu Leu Glu Gln His Ile Asn Ile Asp Ala Leu Thr Ser Asp
930 935 940
Pro Arg Leu Tyr Met Lys Ile Ser Gly Asn Ala Met Leu Gln Leu Gly
945 950 955 960
Pro Phe Leu Tyr Trp Thr Phe Leu Ala Ala Phe Glu Gly Thr Val Phe
965 970 975
Phe Phe Gly Thr Tyr Phe Ile Phe Gln Thr Ser Ser Leu Glu Glu Asn
980 985 990
Ala Lys Val Tyr Gly Asn Trp Thr Phe Gly Thr Ile Val Phe Thr Val
995 1000 1005
Leu Val Phe Thr Val Thr Leu Lys Leu Ala Leu Asp Thr Arg Phe Trp
1010 1015 1020
Thr Trp Ile Asn His Phe Val Ile Trp Gly Ser Leu Ala Phe Tyr Val
1025 1030 1035 1040
Phe Phe Ser Phe Phe Trp Gly Gly Ile Val Trp Pro Phe Leu Lys Gln
1045 1050 1055
Gln Arg Met Tyr Phe Val Phe Ala Gln Met Leu Ser Ser Val Ser Thr
1060 1065 1070
Trp Leu Ala Ile Ile Leu Leu Ile Phe Ile Ser Leu Phe Pro Glu Ile
1075 1080 1085
Leu Leu Ile Val Leu Lys Asn Val Arg Arg Arg Ser Ala Arg Arg Asn
1090 1095 1100
Leu Ser Cys Lys Arg Ala Ser Asp Ser Leu Ser Thr Arg Pro Ser Val
1105 1110 1115 1120
Arg Pro Leu Leu Leu Arg Thr Phe Ser Asp Glu Ser Asn Ile Leu
1125 1130 1135
<210>188
<211>399
<212>PRT
<213>马
<400>188
Met Ser Gln Arg Gln Pro Gln Ser Pro Asn Glu Thr Leu Ile Ser Ile
1 5 10 15
Thr Asn Asp Thr Glu Ser Ser Ser Ser Val Val Pro Asn Asp Asn Thr
20 25 30
Lys Lys Gly Arg Thr Gly Asp Asn Ser Pro Gly Ile Glu Ala Leu Cys
35 40 45
Ala Ile Tyr Ile Thr Tyr Ala Val Ile Ile Ser Val Gly Ile Leu Gly
50 55 60
Asn Ala Ile Leu Ile Lys Val Phe Phe Lys Thr Lys Ser Met Gln Thr
65 70 75 80
Val Pro Asn Ile Phe Ile Thr Ser Leu Ala Phe Gly Asp Leu Leu Leu
85 90 95
Leu Leu Thr Cys Val Pro Val Asp Ala Thr His Tyr Leu Ala Glu Gly
100 105 110
Trp Leu Phe Gly Arg Ile Gly Cys Lys yal Leu Ser Phe Ile Arg Leu
115 120 125
Thr Ser Val Gly Val Ser Val Phe Thr Leu Thr Ile Leu Ser Ala Asp
130 135 140
Arg Tyr Lys Ala Val Val Lys Pro Leu Glu Arg Gln Pro Ser Asn Ala
145 150 155 160
Ile Leu Lys Thr Cys Ala Lys Ala Gly Cys Val Trp Ile Val Ser Met
165 170 175
Ile Ile Ala Leu Pro Glu Ala Ile Phe Ser Asn Val Tyr Thr Phe Gln
180 185 190
Asp Pro Asn Arg Asn Arg Thr Phe Glu Ala Cys Ala Ser Tyr Pro Val
195 200 205
Ser Glu Arg Leu Leu Gln Glu Ile His Ser Leu Leu Cys Phe Leu Val
210 215 220
Phe Tyr Leu Ile Pro Leu Ser Ile Ile Ser Val Tyr Tyr Ser Leu Ile
225 230 235 240
Ala Arg Thr Leu Tyr Lys Ser Thr Leu Asn Ile Pro Thr Glu Glu Gln
245 250 255
Ser His Ala Arg Lys Gln Ile Glu Ser Arg Lys Arg Ile Ala Lys Thr
260 265 270
Val Leu Val Leu yal Ala Leu Phe Ala Leu Cys Trp Leu Pro Asn His
275 280 285
Leu Leu Tyr Leu Tyr Arg Ser Phe Thr Tyr Gln Thr Tyr Met Asp Pro
290 295 300
Ser Ala Val His Phe Leu Val Thr Ile Phe Ser Arg Val Leu Ala Phe
305 310 315 320
Ser Asn Ser Cys Val Asn Pro Phe Ala Leu Tyr Trp Leu Ser Lys Thr
325 330 335
Phe Gln Gln His Phe Lys Ala Gln Leu Phe Cys Cys Lys Ala Glu Val
340 345 350
Pro Asp Pro Ala Pro Ala Asp Ala Thr Leu Asn Ser Leu Ala Val Met
355 360 365
Gly Arg Val Pro Gly Ala Ala Ser Thr Gln Val Ser Glu Ile Ser Val
370 375 380
Thr Trp Phe Thr Gly Cys Ser Met Glu Lys Glu Asp Asp Arg Val
385 390 395
<210>189
<211>350
<212>PRT
<213>马
<400>189
Met Asn Leu Arg Gly Leu Phe Gln Asp Phe Asn Pro Ser Lys Phe Leu
1 5 10 15
Ile Tyr Ala Cys Leu Leu Leu Phe Ser Val Leu Leu Ala Leu Arg Leu
20 25 30
Asp Gly Ile Ile Gln Trp Ser Tyr Trp Ala Val Phe Ala Pro Ile Trp
35 40 45
Leu Trp Lys Leu Met Val Ile Val Gly Ala Ser Val Gly Thr Gly Val
50 55 60
Trp Ala Arg Asn Pro Gln Tyr Arg Ala Glu Gly Glu Thr Cys Val Glu
65 70 75 80
Phe Lys Ala Met Leu Ile Ala Val Gly Ile His Leu Leu Leu Leu Met
85 90 95
Phe Glu Val Leu Val Cys Asp Arg Ile Glu Arg Gly Ser His Phe Trp
100 105 110
Leu Leu Val Phe Met Pro Leu Phe Phe Val Ser Pro Val Ser Val Ala
115 120 125
Ala Cys Val Trp Gly Phe Arg His Asp Arg Ser Leu Glu Leu Glu Ile
130 135 140
Leu Cys Ser Val Asn Ile Leu Gln Phe Ile Phe Ile Ala Leu Arg Leu
145 150 155 160
Asp Lys Ile Ile His Trp Pro Trp Leu Val Val Cys Val Pro Leu Trp
165 170 175
Ile Leu Met Ser Phe Leu Cys Leu Val Val Leu Tyr Tyr Ile Val Trp
180 185 190
Ser Val Leu Phe Leu Arg Ser Met Asp Val Ile Ala Glu Gln Arg Arg
195 200 205
Thr His Ile Thr Met Ala Leu Ser Trp Met Thr Ile Val Val Pro Leu
210 215 220
Leu Thr Phe Glu Ile Leu Leu Val His Lys Leu Asp Gly His Asn Ala
225 230 235 240
Phe Ser Cys Ile Pro Ile Phe Val Pro Leu Trp Leu Ser Leu Ile Thr
245 250 255
Leu Met Ala Thr Thr Phe Gly Gln Lys Gly Gly Asn His Trp Trp Phe
260 265 270
Gly Ile Arg Lys Asp Phe Cys Gln Phe Leu Leu Glu Ile Phe Pro Phe
275 280 285
Leu Arg Glu Tyr Gly Asn Ile Ser Tyr Asp Leu His His Glu Asp Asn
290 295 300
Glu Glu Thr Glu Glu Thr Pro Val Pro Glu Pro Pro Lys Ile Ala Pro
305 310 315 320
Met Phe Arg Lys Lys Thr Arg Val Val Ile Thr Gln Ser Pro Gly Lys
325 330 335
Tyr Val Leu Pro Pro Pro Lys Leu Asn Ile Glu Met Pro Asp
340 345 350
<210>190
<211>194
<212>PRT
<213>马
<400>190
Met Ala Ala Glu Asp Val Ala Ala Thr Gly Ala Asp Pro Ser Glu Leu
1 5 10 15
Glu Gly Gly Gly Leu Leu His Glu Ile Phe Thr Ser Pro Leu Asn Leu
20 25 30
Leu Leu Leu Gly Leu Cys Ile Phe Leu Leu Tyr Lys Ile Val Arg Gly
35 40 45
Asp Gln Pro Gly Ser Gly Asp Ser Asp Asp Asp Glu Pro Pro Pro Leu
50 55 60
Pro Arg Leu Lys Arg Arg Asp Phe Thr Pro Ala Glu Leu Arg Arg Phe
65 70 75 80
Asp Gly Val Gln Asp Pro Arg Ile Leu Met Ala Ile Asn Gly Lys Val
85 90 95
Phe Asp Val Thr Lys Gly Arg Lys Phe Tyr Gly Pro Glu Gly Pro Tyr
100 105 110
Gly Val Phe Ala Gly Arg Asp Ala Ser Arg Gly Leu Ala Thr Phe Cys
115 120 125
Leu Asp Lys Glu Ala Leu Lys Asp Glu Tyr Asp Asp Leu Ser Asp Leu
130 135 140
Thr Pro Ala Gln Gln Glu Thr Leu Ser Asp Trp Asp Ser Gln Phe Thr
145 150 155 160
Phe Lys Tyr His His Val Gly Lys Leu Leu Lys Glu Gly Glu Glu Pro
165 170 175
Thr Val Tyr Ser Asp Glu Glu Glu Pro Lys Asp Glu Asn Ala Arg Lys
180 185 190
Asn Asp
<210>191
<211>703
<212>PRT
<213>马
<400>191
Pro Gly Glu Glu Pro Pro Thr Glu Arg Ser Arg Val Trp Gly Met Val
1 5 10 15
Arg Arg Met Leu Val Leu Val Leu Ile Leu Ser Leu Leu Leu Gly Ser
20 25 30
Ser Val Leu Leu Phe Tyr Ile Phe Gly Ser Cys Gly Pro Arg Pro Cys
35 40 45
Glu Thr Arg Val Cys Trp Asp Leu Leu Ala Arg Tyr Leu Ala Ser Gly
50 55 60
Asn Thr Ser Val Ala Pro Cys Thr Asp Phe Phe Ser Phe Ala Cys Gly
65 70 75 80
Gln Ala Lys Gly Ile Ser Asn Ser Phe Gln Ala Leu Ala Glu Glu Asn
85 90 95
Lys Asn Arg Leu Arg Arg Ile Leu Glu Ala Pro Gly Ser Trp His Pro
100 105 110
Gly Ser Gly Glu Glu Lys Ala Phe Gln Phe Tyr Ser Phe Cys Met Asp
115 120 125
Thr Asp Ala Ile Glu Ala Ala Gly Ala Gly Pro Leu Arg Gln Ile Ile
130 135 140
Glu Glu Leu Gly Gly Trp Arg Ile Ser Gly Ser Trp Thr Ser Leu Asp
145 150 155 160
Phe Asn Arg Thr Leu Arg Leu Leu Met Ser Gln Tyr Asp His Phe Pro
165 170 175
Phe Phe Arg Ala Asp Leu Gln Pro His Pro Thr Pro Pro His Leu Pro
180 185 190
Val Ile Gln Ile Tyr Gln Pro Glu Phe Asp Leu Pro Val Lys Gln Glu
195 200 205
Gln Glu Gln Lys Asn Tyr Ala Gln Ile Val Arg Glu Tyr Leu Thr Tyr
210 215 220
Leu Asn Gln Leu Gly Thr Leu Leu Gly Gly Asp Ala Arg Lys Val Gln
225 230 235 240
Glu His Ala Ala Met Ser Ile Ser Ile Thr Ser Gln Leu Leu Gln Phe
245 250 255
Leu Arg Pro Pro Glu Gln Arg Arg Ala Gln Gly Lys Leu Phe Gln Met
260 265 270
Val Thr Ile Asp Gln Leu Gln Glu Met Ala Pro Ala Ile Asp Trp Leu
275 280 285
Ser Cys Leu Gln Ala Ile Phe Thr Ser Met Ser Leu Ser Pro Ser Gln
290 295 300
Pro Leu Val Val His Asp Leu Glu Tyr Leu Lys Asn Met Ser Tyr Leu
305 310 315 320
Val Glu Glu Gln Leu Ser Lys His Arg Asp Phe Leu Gln Ser His Met
325 330 335
Ile Leu Gly Leu Val Gly Ser Leu Ser Pro Val Leu Asp Ser Lys Phe
340 345 350
Gln Glu Ala His Thr Leu Leu Asn Gln Lys Leu Arg Glu Leu Thr Glu
355 360 365
Arg Pro Pro Leu Pro Thr His Pro Arg Trp Met Lys Cys Val Lys Glu
370 375 380
Thr Gly Asp Tyr Phe Gln Pro Thr Leu Ala Ala Leu Phe Val Arg Glu
385 390 395 400
Ala Phe Ser Pro Ser Thr Gln Ser Ala Ala Met Glu Leu Phe Thr Glu
405 410 415
Ile Lys Asp Ala Leu Ile Thr Arg Leu Arg Ser Leu Pro Trp Met Asp
420 425 430
Glu Arg Thr Gln Lys Glu Ala Gln Asp Lys Val Thr Gln Leu Gln Val
435 440 445
Lys Met Gly Ala Pro Glu Trp Ala Leu Glu Pro Ala Leu Ala Arg Gln
450 455 460
Glu Tyr Asn Asp Ile Gln Leu Gly Ser Ser Tyr Leu Gln Ser His Leu
465 470 475 480
Ser Cys Val Arg Ser Leu Arg Ala Arg Ile Ile Gln Ser Phe Leu Gln
485 490 495
Pro Ser Pro His His Arg Trp Gln Val Leu Pro Trp Glu Val Asn Ala
500 505 510
Tyr Tyr Ser Ile Ser Asp His Val Val Val Phe Pro Ala Gly Leu Phe
515 520 525
Gln Pro Pro Phe Phe His Pro Gly Tyr Pro Arg Ala Val Asn Phe Gly
530 535 540
Ala Ala Gly Ser Ile Met Ala His Glu Leu Leu His Val Phe Tyr Lys
545 550 555 560
Leu Leu Leu Pro Gly Gly Cys Pro Ala Cys Asp Thr Arg Ala Leu Gln
565 570 575
Gly Ala Leu Leu Cys Leu Glu His Leu Tyr Ala Ala Phe Pro Leu Pro
580 585 590
Arg Gly Val Ser Phe Asn Gly Ser Arg Thr Leu Leu Glu Asn Ala Ala
595 600 605
Asp Thr Gly Gly Leu Val Ile Ala Leu Lys Ala Tyr Arg Lys Arg Leu
610 615 620
Leu Trp His Arg Gly Glu Thr Val Leu Pro Asn Leu Asn Leu Ser Pro
625 630 635 640
Gln Gln Leu Phe Phe Arg Ser Tyr Ala Gln Val Met Cys Gly Asp Pro
645 650 655
Ser Thr Gln Asp Ser Gln Asp Thr His Ser Pro Pro Thr Leu Arg Ile
660 665 670
His Gly Pro Leu Ser Asn Ile Pro Asp Phe Ala Arg Tyr Phe Arg Cys
675 680 685
Pro Arg Gly Ala Leu Met Asn Pro Ser Ser His Cys Pro Leu Trp
690 695 700
<210>192
<211>339
<212>PRT
<213>马
<400>192
Met Ala Arg Pro Gly Gln Arg Trp Leu Gly Lys Trp Leu Val Ala Met
1 5 10 15
Val Val Leu Ala Leu Cys Arg Leu Ala Thr Pro Leu Ala Lys Asn Leu
20 25 30
Glu Pro Val Ser Trp Ser Ser Leu Asn Pro Asn Phe Leu Val Gly Lys
35 40 45
Gly Leu Val Ile Tyr Pro Lys Ile Gly Asp Lys Leu Asp Ile Ile Cys
50 55 60
Pro Arg Ala Glu Ala Gly Arg Pro Tyr Glu Tyr Tyr Lys Leu Tyr Leu
65 70 75 80
Val Arg Pro Glu Gln Ala Ala Ala Cys Ser Thr Val Leu Asp Pro Asn
85 90 95
Val Leu Val Thr Cys Asn Arg Pro Glu Gln Glu Ile Arg Phe Thr Ile
100 105 110
Lys Phe Gln Glu Phe Ser Pro Asn Tyr Met Gly Leu Glu Phe Lys Lys
115 120 125
His His Asp Tyr Tyr Ile Thr Cys Glu Phe Leu Ala Asp Leu Pro Gly
130 135 140
Leu Leu Ala Glu Pro Phe Gly Ile Gly Gln Leu Phe Ser Leu Ser Leu
145 150 155 160
His Arg Lys Phe Phe Pro Asp Pro Lys Ser Arg Ile Pro Ser Pro Cys
165 170 175
Thr Ser Ser Leu Ala Pro Gly Gln Ser Gly Gly Ser Leu Gly Val Leu
180 185 190
Gly Trp Ser Pro Arg Gly Gln Lys Pro Phe Leu Gly Cys Pro Phe Arg
195 200 205
Pro Tyr Thr Val Asn Gln Glu Glu Lys Ser Gly Ser Gly Asp Pro Asp
210 215 220
Ser Phe Phe Asn Ser Lys Val Ala Leu Phe Ala Ala Val Gly Ala Gly
225 230 235 240
Cys Val Ile Phe Leu Leu Ile Ile Ile Phe Leu Thr Val Leu Leu Leu
245 250 255
Lys Leu Arg Lys Arg His Arg Lys His Thr Gln Gln Arg Ala Pro Ala
260 265 270
Leu Ser Leu Ser Thr Leu Ala Ser Pro Lys Gly Gly Ser Gly Thr Ala
275 280 285
Gly Thr Glu Pro Ser Asp Ile Ile Ile Pro Leu Arg Thr Thr Glu Asn
290 295 300
Asn Tyr Cys Pro His Tyr Glu Lys Val Ser Gly Asp Tyr Gly His Pro
305 310 315 320
Val Tyr Ile Val Gln Glu Met Pro Pro Gln Ser Pro Ala Asn Ile Tyr
325 330 335
Tyr Lys Val
<210>193
<211>548
<212>PRT
<213>马
<400>193
Gly Val Phe Leu Ile Pro Tyr Val Leu Ile Ala Leu Ile Gly Gly Ile
1 5 10 15
Pro Ile Phe Phe Leu Glu Ile Ser Leu Gly Gln Phe Met Lys Ala Gly
20 25 30
Ser Ile Asn Val Trp Asn Ile Cys Pro Leu Phe Lys Gly Leu Gly Tyr
35 40 45
Ala Ser Met Val Ile Val Phe Tyr Cys Asn Thr Tyr Tyr Ile Met Val
50 55 60
Leu Ala Trp Gly Phe Tyr Tyr Leu Val Lys Ser Phe Thr Thr Thr Leu
65 70 75 80
Pro Trp Ala Thr Cys Gly His Thr Trp Asn Thr Pro Asp Cys Val Glu
85 90 95
Ile Phe Arg His Glu Asp Cys Ala Asn Ala Ser Leu Ala Asn Leu Thr
100 105 110
Cys Asp Gln Leu Ala Asp Arg Arg Ser Pro Val Ile Glu Phe Trp Glu
115 120 125
Asn Lys Val Leu Arg Leu Ser Gly Gly Leu Glu Val Pro Gly Ala Leu
130 135 140
Asn Trp Glu Val Thr Leu Cys Leu Leu Ala Cys Trp Val Leu Val Tyr
145 150 155 160
Phe Cys Val Trp Lys Gly Val Lys Ser Thr Gly Lys Ile Val Tyr Phe
165 170 175
Thr Ala Thr Phe Pro Tyr Val Val Leu Val Val Leu Leu Val Arg Gly
180 185 190
Val Leu Leu Pro Gly Ala Leu Asp Gly Ile Ile Tyr Tyr Leu Lys Pro
195 200 205
Asp Trp Ser Lys Leu Gly Ser Pro Gln Val Trp Ile Asp Ala Gly Thr
210 215 220
Gln Ile Phe Phe Ser Tyr Ala Ile Gly Leu Gly Ala Leu Thr Ala Leu
225 230 235 240
Gly Ser Tyr Asn Arg Phe Asn Asn Asn Cys Tyr Lys Asp Ala Ile Ile
245 250 255
Leu Ala Leu Ile Asn Ser Gly Thr Ser Phe Phe Ala Gly Phe Val Val
260 265 270
Phe Ser Ile Leu Gly Phe Met Ala Ala Glu Gln Gly Val His Ile Ser
275 280 285
Lys Val Ala Glu Ser Gly Pro Gly Leu Ala Phe Ile Ala Tyr Pro Arg
290 295 300
Ala Val Thr Leu Met Pro Val Ala Pro Leu Trp Ala Ala Leu Phe Phe
305 310 315 320
Phe Met Leu Leu Leu Leu Gly Leu Asp Ser Gln Phe Val Gly Val Glu
325 330 335
Gly Phe Ile Thr Gly Leu Leu Asp Leu Leu Pro Ala Ser Tyr Tyr Phe
340 345 350
Arg Phe Gln Arg Glu Ile Ser Val Ala Leu Cys Cys Ala Leu Cys Phe
355 360 365
Val Ile Asp Leu Ser Met Val Thr Asp Gly Gly Met Tyr Val Phe Gln
370 375 380
Leu Phe Asp Tyr Tyr Ser Ala Ser Gly Thr Thr Leu Leu Trp Gln Ala
385 390 395 400
Phe Trp Glu Cys Val Val Val Ala Trp Val Tyr Gly Ala Asp Arg Phe
405 410 415
Met Asp Asp Val Ala Cys Met Ile Gly Tyr Arg Pro Cys Pro Trp Met
420 425 430
Lys Trp Cys Trp Ser Phe Phe Thr Pro Leu Val Cys Met Gly Ile Phe
435 440 445
Ile Phe Asn Val Val Tyr Tyr Lys Pro Leu Val Tyr Asn Asn Thr Tyr
450 455 460
Val Tyr Pro Trp Trp Gly Glu Ala Met Gly Trp Ala Phe Ala Leu Ser
465 470 475 480
Ser Met Leu Cys Val Pro Leu His Leu Leu Gly Cys Leu Leu Arg Ala
485 490 495
Lys Gly Thr Val Ala Glu Arg Trp Gln His Leu Thr Gln Pro Val Trp
500 505 510
Gly Leu His His Leu Glu Tyr Arg Ala Gln Asp Ser Asp Val Arg Gly
515 520 525
Leu Thr Thr Leu Thr Pro Val Ser Glu Ser Ser Lys Val Val Val Val
530 535 540
Glu Ser Val Met
545
<210>194
<211>439
<212>PRT
<213>马
<400>194
Met Lys Arg Gly Val Arg Val Pro Val Arg Gly Glu Thr Thr Thr Ala
1 5 10 15
Leu Tyr Leu Ser Ser Thr Tyr Arg Ser Ala Gly Asp Gly Met Trp Gln
20 25 30
Ala Leu Thr Leu Leu Phe Ser Leu Leu Pro Cys Ala Leu Val Gln Leu
35 40 45
Thr Leu Leu Phe Val His Arg Asp Phe Ser Arg Asp Arg Pro Leu Val
50 55 60
Leu Leu Leu His Leu Leu Gln Leu Gly Pro Leu Phe Arg Cys Phe Glu
65 70 75 80
Val Phe Cys Ile Tyr Cys Gln Ser Asn His Val Glu Glu Pro Tyr Val
85 90 95
Ser Ile Ile Lys Lys Arg Gln Met Pro Arg Asn Gly Leu Ser Glu Glu
100 105 110
Ile Glu Arg Glu Val Gly Gln Ala Glu Gly Lys Leu Phe Thr His Arg
115 120 125
Ser Ala Phe Ser Arg Ala Ser Val Ile Gln Ala Phe Leu Gly Ser Ala
130 135 140
Pro Gln Leu Thr Leu Gln Leu Tyr Ile Ser Thr Leu Gln Arg Lys Val
145 150 155 160
Thr Ile Thr Arg Cys Phe Phe Met Val Leu Ser Leu Leu Ser Ile Val
165 170 175
Tyr Gly Ala Leu Arg Cys Asn Ile Leu Ala Ile Lys Ile Lys Tyr Asp
180 185 190
Glu Tyr Leu Val Lys Val Lys Pro Leu Ala Tyr Val Cys Ile Phe Leu
195 200 205
Trp Arg Ser Phe Glu Ile Ala Thr Arg Val Val Val Leu Val Leu Phe
210 215 220
Thr Ser Val Leu Lys Ala Trp Val Val Met Ile Ile Leu Ile Asn Phe
225 230 235 240
Leu Ser Phe Phe Phe Tyr Pro Trp Ile Leu Phe Trp Cys Ser Gly Ser
245 250 255
Pro Phe Pro Glu Asn Ile Glu Lys Ala Leu Ser Arg Val Gly Thr Thr
260 265 270
Ile Val Leu Cys Phe Leu Thr Phe Leu Tyr Ala Gly Ile Asn Met Phe
275 280 285
Cys Trp Ser Ala Val Gln Leu Lys Ile Asn Asn Pro Asp Leu Ile Ser
290 295 300
Lys Ser Gln Asn Trp Tyr Gln Leu Leu Val Tyr Tyr Met Leu Arg Phe
305 310 315 320
Val Glu Asn Ala Phe Leu Leu Leu Met Trp Tyr Leu Tyr Lys Thr Asp
325 330 335
Ile Tyr Met Tyr Val Cys Ala Pro Leu Leu Ile Leu Gln Leu Leu Ile
340 345 350
Gly Tyr Cys Thr Ala Ile Leu Phe Met Leu Val Phe Tyr Gln Phe Phe
355 360 365
His Pro Cys Lys Lys Leu Phe Ser Thr Ser Val Ser Glu Gly Leu Gln
370 375 380
Glu Trp Leu Arg Cys Val Cys Cys Asp Cys Arg Arg Gln Lys Ser Cys
385 390 395 400
Glu Ser Val Gly Lys Ala Asp Leu Arg Ser Pro Ala Asp Ile Asp Glu
405 410 415
Thr Pro Ser Ser Ser Lys Ile Ser Ser Met Pro Ser Glu Ile Leu Asn
420 425 430
Pro Asn Glu Phe Cys Ser Ile
435
<210>195
<211>220
<212>PRT
<213>马
<400>195
Met Ser Ile Leu Leu Pro Asn Met Ala Glu Phe Asp Thr Ile Ser Glu
1 5 10 15
Leu Glu Glu Glu Glu Glu Glu Ala Ala Thr Ser Ser Ser Ser Pro Ser
20 25 30
Ser Ser Ser Val Ser Gly Pro Asp Asp Asp Asp Glu Glu Asp Glu Glu
35 40 45
Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu
50 55 60
Thr Pro Pro Pro Pro Arg Val Val Ser Glu Glu His Leu Arg Arg Tyr
65 70 75 80
Ala Pro Asp Pro Val Leu Val Arg Gly Ala Gly His Ile Thr Val Phe
85 90 95
Gly Leu Ser Asn Lys Phe Asp Thr Glu Phe Pro Ser Val Leu Thr Gly
100 105 110
Lys Val Ala Pro Glu Glu Phe Lys Thr Ser Ile Gly Arg Val Asn Ala
115 120 125
Cys Leu Lys Lys Ala Leu Pro Val Asn Val Lys Trp Leu Leu Cys Gly
130 135 140
Cys Leu Cys Cys Cys Cys Thr Leu Gly Cys Ser Leu Trp Pro Val Val
145 150 155 160
Cys Leu Asn Lys Arg Thr Arg Arg Ser Ile Gln Lys Leu Leu Glu Trp
165 170 175
Glu Asn Asn Arg Leu Tyr His Lys Leu Ala Leu His Trp Lys Leu Thr
180 185 190
Lys Arg Lys Cys Glu Thr Ser Asn Met Met Glu Tyr Val Ile Leu Ile
195 200 205
Glu Phe Leu Pro Lys Tyr Pro Ile Phe Arg Pro Asp
210 215 220
<210>196
<211>1501
<212>PRT
<213>马
<400>196
Met Asp Pro Ser Val Asp Val Asn Ser Val Thr Ile Ser Val Glu Gly
1 5 10 15
Met Thr Cys Ser Ser Cys Val Trp Thr Ile Glu Gln Gln Ile Gly Lys
20 25 30
Leu Ser Gly Val His His Ile Lys Val Ser Leu Glu Glu Lys Cys Ala
35 40 45
Thr Ile Ile Tyr Asp Pro Lys Leu Gln Thr Pro Lys Thr Leu Gln Glu
50 55 60
Ala Ile Asp Asp Met Gly Phe Asp Ala Ile Leu Asn His Pro Asn Pro
65 70 75 80
Leu Pro Val Leu Thr Asp Thr Val Phe Leu Thr Val Thr Ala Ser Leu
85 90 95
Ser Pro Pro Trp Asp His Ile Gln Ser Thr Leu Leu Lys Thr Lys Gly
100 105 110
Val Thr Asp Ile Lys Ile Ser Pro Gln Gln Arg Thr Ala Val Val Thr
115 120 125
Ile Ile Pro Ser Val Val Thr Ala Asn Gln Ile Ile Glu Leu Val Pro
130 135 140
Asp Leu Ser Leu Asp Ile Gly Thr Leu Glu Lys Lys Ser Gly Thr Cys
145 150 155 160
Glu Asp Tyr Ser Met Ala Gln Ala Gly Glu Val Met Val Lys Met Lys
165 170 175
Val Glu Gly Met Thr Cys His Ser Cys Thr Ser Thr Ile Glu Gly Lys
180 185 190
Ile Gly Lys Leu Gln Gly Val Gln Arg Ile Lys Val Ser Leu Asp Asn
195 200 205
Gln Glu Ala Thr Ile Val Tyr Gln Pro His Leu Ile Thr Val Glu Glu
210 215 220
Ile Lys Lys Gln Ile Glu Ala Ala Gly Phe Pro Ala Phe Ile Lys Lys
225 230 235 240
Gln Pro Lys Phe Leu Lys Leu Gly Ala Ile Asp Ile Glu Arg Leu Lys
245 250 255
Asn Thr Pro Val Lys Ser Ser Glu Arg Pro Gln Gln Arg Ser Pro Ser
260 265 270
Cys Thr Asn Asp Ser Ala Val Thr Phe Ile Val Asp Gly Met His Cys
275 280 285
Lys Ser Cys Val Ser Asn Ile Glu Ser Ala Leu Ser Thr Leu Gln Tyr
290 295 300
Val Ser Ser Val Val Val Ser Leu Glu Asn Arg Ser Ala Ile Val Lys
305 310 315 320
Tyr Asn Ala Ser Leu Val Thr Pro Glu Thr Leu Arg Lys Ala Ile Glu
325 330 335
Ala Ile Ser Pro Gly Gln Tyr Arg Val Ser Phe Pro Ser Glu Val Glu
340 345 350
Ser Thr Ser Asn Ser Pro Ser Gly Ser Ser Leu His Lys Ile Pro Leu
355 360 365
Asn Ile Val Ser Gln Pro Leu Thr Gln Glu Thr Val Ile Asn Ile Asp
370 375 380
Gly Met Thr Cys Asn Ser Cys Val Gln Ser Ile Glu Gly Val Ile Ser
385 390 395 400
Lys Lys Ala Gly Val Lys Ser Ile Arg Val Ser Leu Ala Asn Gly Asn
405 410 415
Gly Thr Val Glu Tyr Asp Pro Leu Leu Thr Ser Pro Glu Thr Leu Arg
420 425 430
Lys Ala Ile Glu Asp Met Gly Phe Asp Ala Thr Leu Ser Asp Thr Asn
435 440 445
Glu Pro Leu Val Val Ile Ala Gln Pro Ser Ser Glu Val Pro Leu Leu
450 455 460
Thr Ser Thr Asn Glu Phe Cys Pro Lys Thr Met Thr Pro Thr His Asp
465 470 475 480
Lys Glu Glu Ala Lys Thr Ser Ser Lys Cys Tyr Ile Gln Val Thr Gly
485 490 495
Met Thr Cys Ala Ser Cys Val Ala Asn Ile Glu Arg Asn Leu Arg Arg
500 505 510
Glu Glu Gly Ile Tyr Ser Val Leu Val Ala Leu Met Ala Gly Lys Ala
515 520 525
Glu Val Arg Tyr Asn Pro Ala Val Ile Gln Pro Pro Ile Ile Ala Glu
530 535 540
Phe Ile Arg Glu Leu Gly Phe Gly Ala Thr Val Ile Glu Asn Ala Asp
545 550 555 560
Gly Gly Asp Gly Ile Leu Glu Leu Val Val Arg Gly Met Thr Cys Ala
565 570 575
Ser Cys Val His Lys Ile Glu Ser Thr Leu Thr Lys His Arg Gly Ile
580 585 590
Phe Tyr Cys Ser Val Ala Leu Ala Thr Asn Lys Ala His Ile Lys Tyr
595 600 605
Asp Pro Glu Ile Ile Gly Pro Arg Asp Ile Ile His Thr Ile Glu Ser
610 615 620
Leu Gly Phe Lys Ala Ser Leu Val Lys Lys Asp Arg Ser Ala Ser His
625 630 635 640
Leu Asp His Lys Arg Glu Ile Arg Gln Trp Arg Arg Ser Phe Leu Val
645 650 655
Ser Leu Phe Phe Cys Ile Pro Val Met Gly Leu Met Ile Tyr Met Met
660 665 670
Val Met Asp His His Leu Glu Thr Leu His His Asn Gln Asn Ile Ser
675 680 685
Gln Glu Glu Met Ile His Ile His Ser Ser Met Phe Leu Glu Arg Gln
690 695 700
Ile Leu Pro Gly Leu Ser Ile Met Asn Leu Leu Ser Phe Leu Leu Cys
705 710 715 720
Val Pro Pro Lys Glu Phe Phe Gly Gly Trp His Phe Tyr Ile Gln Ala
725 730 735
Tyr Lys Ala Leu Lys His Lys Thr Ala Asn Met Asp Val Leu Ile Val
740 745 750
Leu Ala Thr Thr Ile Ala Phe Ala Tyr Ser Leu Val Ile Leu Leu Val
755 760 765
Ala Met Tyr Glu Arg Ala Lys Val Asn Pro Ile Thr Phe Phe Asp Thr
770 775 780
Pro Pro Met Leu Phe Val Phe Ile Ala Leu Gly Arg Trp Leu Glu His
785 790 795 800
Ile Ala Lys Gly Lys Thr Ser Glu Ala Leu Ala Lys Leu Ile Ser Leu
805 810 815
Gln Ala Thr Glu Ala Thr Ile Val Thr Leu Asp Ser Asp Asn Ile Leu
820 825 830
Leu Ser Glu Glu Gln Val Asp Val Glu Leu Val Gln Arg Gly Asp Ile
835 840 845
Ile Lys Val Val Pro Gly Gly Lys Phe Pro Val Asp Gly Arg Val Ile
850 855 860
Glu Gly His Ser Met Val Asp Glu Ser Leu Ile Thr Gly Glu Ala Met
865 870 875 880
Pro Val Ala Lys Lys Pro Gly Ser Thr Val Ile Ala Gly Ser Ile Asn
885 890 895
Gln Asn Gly Ser Leu Leu Ile Arg Ala Thr His Val Gly Gly Asp Thr
900 905 910
Thr Leu Ser Gln Ile Val Lys Leu Val Glu Glu Ala Gln Thr Ser Lys
915 920 925
Ala Pro Ile Gln Gln Phe Ala Asp Lys Leu Ser Gly Tyr Phe Val Pro
930 935 940
Phe Ile Val Ile Val Ser Ile Ala Thr Leu Leu Val Trp Ile Ile Ile
945 950 955 960
Gly Phe Leu Asn Phe Glu Ile Val Glu Ala Tyr Phe Pro Gly Tyr Asn
965 970 975
Arg Ser Ile Ser Arg Thr Glu Thr Ile Val Arg Phe Ala Phe Gln Ala
980 985 990
Ser Ile Thr Val Leu Cys Ile Ala Cys Pro Cys Ser Leu Gly Leu Ala
995 1000 1005
Thr Pro Thr Ala Val Met Val Gly Thr Gly Val Gly Ala Gln Asn Gly
1010 1015 1020
Ile Leu Ile Lys Gly Gly Glu Pro Leu Glu Met Ala His Lys Val Lys
1025 1030 1035 1040
Val Val Val Phe Asp Lys Thr Gly Thr Ile Thr His Gly Thr Pro Val
1045 1050 1055
Val Asn Gln Val Lys Val Leu Val Glu Ser Asn Arg Met Ser Arg Asn
1060 1065 1070
Lys Ile Leu Ala Ile Val Gly Thr Ala Glu Ser Asn Ser Glu His Pro
1075 1080 1085
Leu Gly Ala Ala Ile Thr Lys Tyr Cys Lys Lys Glu Leu Asn Thr Glu
1090 1095 1100
Thr Leu Gly Thr Cys Thr Asp Phe Gln Val Val Pro Gly Cys Gly Ile
1105 1110 1115 1120
Ser Cys Lys Val Thr Asn Ile Glu Gly Phe Leu His Lys Asn Asn Trp
1125 1130 1135
Lys Ile Glu Glu Asn Asn Ile Lys Asn Ala Ser Leu Val Gln Ile Asp
1140 1145 1150
Ala Ser Asn Glu Gln Pro Ser Thr Ser Ser Ser Ile Ile Ile Asp Ala
1155 1160 1165
Gln Leu Ser Asn Ser Leu Asn Ser Gln Gln Tyr Lys Val Leu Ile Gly
1170 1175 1180
Asn Arg Glu Trp Met Ile Arg Asn Gly Leu Val Ile Asn Asn Asp Val
1185 1190 1195 1200
Asp Asp Ser Met Asn Glu His Glu Arg Lys Gly Arg Thr Ala Val Leu
1205 1210 1215
Val Ala Val Asp Asp Glu Leu Cys Gly Leu Ile Ala Ile Ala Asp Thr
1220 1225 1230
Val Lys Pro Glu Ala Glu Leu Ala Val His Thr Leu Lys Ser Met Gly
1235 1240 1245
Leu Glu Val Val Leu Met Thr Gly Asp Asn Ser Lys Thr Ala Arg Ser
1250 1255 1260
Ile Ala Ser Gln Val Gly Ile Thr Lys Val Phe Ala Glu Val Leu Pro
1265 1270 1275 1280
Ser His Lys Val Ala Lys Val Lys Gln Leu Gln Glu Glu Gly Lys Gln
1285 1290 1295
Val Ala Met Val Gly Asp Gly Ile Asn Asp Ser Pro Ala Leu Ala Met
1300 1305 1310
Ala Asn Val Gly Ile Ala Ile Gly Thr Gly Thr Asp Val Ala Ile Glu
1315 1320 1325
Ala Ala Asp Val Val Leu Ile Arg Asn Asp Leu Leu Asp Val Val Ala
1330 1335 1340
Ser Ile Asp Leu Ser Arg Lys Thr Val Lys Arg Ile Arg Ile Asn Phe
1345 1350 1355 1360
Val Phe Ala Leu Ile Tyr Asn Leu Val Gly Ile Pro Ile Ala Ala Gly
1365 1370 1375
Val Phe Met Pro Ile Gly Leu Val Leu Gln Pro Trp Met Gly Ser Ala
1380 1385 1390
Ala Met Ala Ala Ser Ser Val Ser Val Val Leu Ser Ser Leu Phe Leu
1395 1400 1405
Lys Leu Tyr Arg Lys Pro Thr Tyr Glu Asn Tyr Glu Leu His Ala Arg
1410 1415 1420
Ser Gln Met Gly Gln Lys Ser Pro Ser Glu Ile Ser Val His Val Gly
1425 1430 1435 1440
Ile Asp Asp Thr Ser Arg Asn Ser Pro Lys Leu Gly Leu Leu Asp Arg
1445 1450 1455
Ile Val Asn Tyr Ser Arg Ala Ser Ile Asn Ser Leu Leu Ser Asp Lys
1460 1465 1470
Arg Ser Leu Asn Ser Ile Gly Thr Ser Glu Pro Asp Lys His Ser Leu
1475 1480 1485
Leu Val Gly Asp Cys Arg Glu Asp Asp Asp Thr Ala Leu
1490 1495 1500
<210>197
<211>382
<212>PRT
<213>马
<400>197
Met Val Phe Ala Phe Trp Lys Val Phe Leu Ile Leu Asn Cys Leu Ala
1 5 10 15
Gly Gln Val Thr Ala Val Gln Val Thr Ile Pro Asp Ser Phe Val Asn
20 25 30
Val Thr Val Gly Ser Asp Val Thr Leu Ile Cys Thr Tyr Thr Thr Thr
35 40 45
Val Ala Ser Arg Asp Lys Leu Ser Ile Gln Trp Ser Phe Phe His Lys
50 55 60
Lys Glu Leu Gln Pro Val Ser Ile Tyr Tyr Ser Glu Gly Gly Gln Ala
65 70 75 80
Ala Ala Ile Gly Gln Phe Lys Gly Arg Ile Val Gly Ser Asn Glu Pro
85 90 95
Gly Asn Ala Ser Ile Thr Ile Ser His Met Gln Pro Ala Asp Ser Gly
100 105 110
Ile Tyr Ile Cys Asp Val Asn Asn Pro Pro Asp Phe Val Gly Thr Asn
115 120 125
Gln Gly Ile Leu Asn Val Ser Val Leu Val Lys Pro Ser Lys Pro Phe
130 135 140
Cys Ser Ile Gln Gly Ile Pro Glu Thr Gly His Pro Ile Ser Leu Ser
145 150 155 160
Cys Leu Ser Val Leu Gly Thr Pro Ser Pro Val Tyr Tyr Trp Tyr Arg
165 170 175
Leu Glu Gly Arg Asp Ile Val Pro Val Lys Glu Ser Phe Asn Pro Ala
180 185 190
Thr Gly Ile Leu Val Ile Gly Asn Leu Thr Asn Phe Glu Gln Gly Tyr
195 200 205
Tyr Gln Cys Thr Ala Ile Asn Ile Leu Gly Asn Ser Ser Cys Glu Ile
210 215 220
Asp Leu Thr Ser Ser His Pro Glu Val Gly Ile Ile Val Gly Ala Leu
225 230 235 240
Val Gly Thr Leu Val Gly Ala Ala Ile Ile Thr Ser Ile Val Cys Phe
245 250 255
Ala Arg Ser Lys Ala Lys Ala Lys Gly Lys Gly Lys Glu Arg Lys Arg
260 265 270
Asn Ser Lys Thr Asn Pro Glu Leu Glu Pro Met Arg Met Ile Asn Gln
275 280 285
Ser Thr Glu Cys Glu Thr Met Pro Asn Glu Asp Ala Val Gln Leu Glu
290 295 300
Ala Thr Leu Pro Val Ser Thr His Glu Thr Asp Pro Asp Thr Ile Leu
305 310 315 320
Gly Leu Asp His Glu Pro Ile Pro Glu Pro Glu Pro Val Pro Glu Pro
325 330 335
Val Pro Glu Pro Thr Ala Gly Pro Glu Leu Val Pro Val Pro Glu Ile
340 345 350
Glu Ile His Leu Glu Pro Glu Pro Glu Pro Glu Pro Glu Thr Glu Pro
355 360 365
Glu Pro Gly Ile Val Val Glu Pro Phe Cys Asp Glu Glu Lys
370 375 380
<210>198
<211>351
<212>PRT
<213>马
<400>198
Met Ala Val Leu Val Val Leu Leu Ser Leu Leu Val Ala Gly Val Leu
1 5 10 15
Gly Asn Glu Phe Ser Ile Leu Lys Ser Pro Gly Ser Val Val Phe Arg
20 25 30
Asp Gly Asn Trp Pro Ile Pro Gly Glu Arg Ile Pro Asp Val Ala Ala
35 40 45
Leu Ser Met Gly Phe Ser Val Lys Glu Asp Leu Ser Trp Pro Gly Leu
50 55 60
Ala Val Gly Asn Leu Phe His Arg Pro Arg Ala Thr Val Met Val Met
65 70 75 80
Val Lys Gly Val Asp Lys Leu Ala Leu Pro Pro Gly Ser Val Ile Ser
85 90 95
Tyr Pro Leu Glu Asn Ala Val Pro Phe Ser Leu Asp Ser Val Ala Asn
100 105 110
Ser Ile His Ser Leu Phe Ser Glu Glu Thr Pro Val Val Leu Gln Leu
115 120 125
Ala Pro Ser Glu Glu Arg Val Tyr Met Val Gly Lys Ala Asn Ser Val
130 135 140
Phe Glu Asp Leu Ser Val Thr Leu Arg Gln Leu Arg Asn Arg Leu Phe
145 150 155 160
Gln Glu Asn Ser Ile Leu Asn Ser Leu Pro Leu Asn Ser Leu Ser Arg
165 170 175
Asn Asn Glu Val Asp Leu Leu Phe Leu Ser Glu Leu Gln Val Leu His
180 185 190
Asp Ile Ser Ser Leu Leu Ser Arg His Lys His Leu Ala Lys Asp His
195 200 205
Ser Pro Asp Leu Tyr Ser Leu Glu Leu Ala Gly Leu Asp Glu Ile Gly
210 215 220
Lys His Tyr Gly Glu Asp Ser Glu Gln Phe Arg Asp Ala Ser Lys Ile
225 230 235 240
Leu Val Asp Ala Leu Gln Lys Phe Ala Asp Asp Met Tyr Asn Leu Tyr
245 250 255
Gly Gly Asn Ala Val Val Glu Leu Val Thr Ile Lys Ser Phe Asp Thr
260 265 270
Ser Val Val Arg Lys Thr Arg Thr Ile Leu Glu Ala Glu Gln Ala Lys
275 280 285
Ser Pro Ser Ser Pro Tyr Asn Leu Ala Tyr Lys Tyr Asn Leu Glu Tyr
290 295 300
Pro Val Val Phe Asn Met Val Leu Trp Ile Met Ile Ala Leu Ala Leu
305 310 315 320
Ala Val Ile Ile Thr Ser Tyr Asn Ile Trp Asn Met Asp Pro Gly Tyr
325 330 335
Asp Ser Ile Ile Tyr Arg Met Thr Asn Gln Lys Ile Arg Met Asp
340 345 350
<210>199
<211>1250
<212>PRT
<213>马
<400>199
Met Gly Asp Met Ala Asn Ser Ser Ile Glu Phe His Pro Lys Pro Gln
1 5 10 15
Gln Gln Arg Glu Ala Pro His Ala Gly Gly Phe Gly Cys Thr Leu Ala
20 25 30
Glu Leu Arg Ser Leu Met Glu Leu Arg Gly Ala Glu Ala Leu Gln Lys
35 40 45
Val Gln Glu Ala Tyr Gly Asp Val Ser Gly Leu Cys Arg Arg Leu Lys
50 55 60
Thr Ser Pro Thr Glu Gly Leu Ala Asp Asn Ala Ser Asp Leu Glu Lys
65 70 75 80
Arg Arg Gln Ile Tyr Gly Gln Asn Phe Ile Pro Pro Lys Gln Pro Lys
85 90 95
Thr Phe Leu Gln Leu Val Trp Glu Ala Leu Gln Asp Val Thr Leu Ile
100 105 110
Ile Leu Glu Val Ala Ala Ile Val Ser Leu Gly Leu Ser Phe Tyr Ala
115 120 125
Pro Pro Gly Glu Glu Ser Glu Ala Cys Gly Asn Val Ser Ala Gly Ala
130 135 140
Glu Asp Glu Gly Glu Ala Glu Ala Gly Trp Ile Glu Gly Ala Ala Ile
145 150 155 160
Leu Leu Ser Val Val Cys Val Val Leu Val Thr Ala Phe Asn Asp Trp
165 170 175
Ser Lys Glu Lys Gln Phe Arg Gly Leu Gln Ser Arg Ile Glu Gln Glu
180 185 190
Gln Lys Phe Thr Val Ile Arg Asn Gly Gln Leu Leu Gln Val Pro Val
195 200 205
Ala Ala Leu Val Val Gly Asp Ile Ala Gln Val Lys Tyr Gly Asp Leu
210 215 220
Leu Pro Ala Asp Gly Val Leu Ile Gln Gly Asn Asp Leu Lys Ile Asp
225 230 235 240
Glu Ser Ser Leu Thr Gly Glu Ser Asp His Val Arg Lys Ser Ala Asp
245 250 255
Lys Asp Pro Met Leu Leu Ser Gly Thr His Val Met Glu Gly Ser Gly
260 265 270
Arg Met Val Val Thr Ala Val Gly Val Asn Ser Gln Thr Gly Ile Ile
275 280 285
Phe Thr Leu Leu Gly Ala Gly Gly Glu Glu Glu Glu Lys Lys Asp Lys
290 295 300
Lys Gly Lys Gly Lys Gln Cys Lys Gln Gln Asp Gly Ala Met Glu Ser
305 310 315 320
Ser Gln Thr Lys Ala Lys Lys Gln Asp Gly Ala Val Ala Met Glu Met
325 330 335
Gln Pro Leu Lys Ser Ala Glu Gly Gly Glu Met Glu Glu Arg Glu Lys
340 345 350
Lys Lys Ala Thr Val Pro Lys Lys Glu Lys Ser Val Leu Gln Gly Lys
355 360 365
Leu Thr Lys Leu Ala Val Gln Ile Gly Lys Ala Gly Leu Val Met Ser
370 375 380
Ala Ile Thr Val Ile Ile Leu Val Leu Tyr Phe Val Ile Glu Thr Phe
385 390 395 400
Val Val Asp Gly Arg Val Trp Leu Ala Glu Cys Thr Pro Val Tyr Val
405 410 415
Gln Tyr Phe Val Lys Phe Phe IIe Ile Gly Val Thr Val Leu Val Val
420 425 430
Ala Val Pro Glu Gly Leu Pro Leu Ala Val Thr Ile Ser Leu Ala Tyr
435 440 445
Ser Val Lys Lys Met Met Arg Asp Asn Asn Leu Val Arg His Leu Asp
450 455 460
Ala Cys Glu Thr Met Gly Asn Ala Thr Ala Ile Cys Ser Asp Lys Thr
465 470 475 480
Gly Thr Leu Thr Thr Asn Arg Met Thr Val Val Gln Ser Tyr Leu Gly
485 490 495
Asp Thr His Tyr Lys Glu Ile Pro Ala Pro Ser Ala Leu Thr Pro Lys
500 505 510
Ile Leu Asp Leu Leu Val His Ala Ile Ser Ile Asn Ser Ala Tyr Thr
515 520 525
Thr Lys Ile Leu Pro Pro Glu Lys Glu Gly Ala Leu Pro Arg Gln Val
530 535 540
Gly Asn Lys Thr Glu Cys Ala Leu Leu Gly Phe Val Leu Asp Leu Lys
545 550 555 560
Arg Asp Phe Gln Pro Val Arg Glu Gln Ile Pro Glu Asp Lys Leu Tyr
565 570 575
Lys Val Tyr Thr Phe Asn Ser Val Arg Lys Ser Met Ser Thr Val Ile
580 585 590
Arg Thr Pro Asp Gly Gly Phe Arg Leu Phe Ser Lys Gly Ala Ser Glu
595 600 605
Ile Leu Leu Lys Lys Cys Thr Asn Ile Leu Asn Ser Asn Gly Glu Leu
610 615 620
Arg Ser Phe Arg Pro Arg Asp Arg Asp Asp Met Val Lys Lys Ile Ile
625 630 635 640
Glu Pro Met Ala Cys Asp Gly Leu Arg Thr Ile Cys Ile Ala Tyr Arg
645 650 655
Asp Phe Ser Ala Ala Gln Glu Pro Asp Trp Asp Asn Glu Asn Glu Val
660 665 670
Val Gly Asp Leu Thr Cys Ile Ala Val Val Gly Ile Glu Asp Pro Val
675 680 685
Arg Pro Glu Val Pro Glu Ala Ile Arg Lys Cys Gln Arg Ala Gly Ile
690 695 700
Thr Val Arg Met Val Thr Gly Asp Asn Ile Asn Thr Ala Arg Ala Ile
705 710 715 720
Ala Ala Lys Cys Gly Ile Ile Gln Pro Gly Glu Asp Phe Leu Cys Leu
725 730 735
Glu Gly Lys Glu Phe Asn Arg Arg Ile Arg Asn Glu Lys Gly Glu Ile
740 745 750
Glu Gln Glu Arg Leu Asp Lys Val Trp Pro Lys Leu Arg Val Leu Ala
755 760 765
Arg Ser Ser Pro Thr Asp Lys His Thr Leu Val Lys Gly Ile Ile Asp
770 775 780
Ser Thr Thr Gly Glu Gln Arg Gln Val Val Ala Val Thr Gly Asp Gly
785 790 795 800
Thr Asn Asp Gly Pro Ala Leu Lys Lys Ala Asp Val Gly Phe Ala Met
805 810 815
Gly Ile Ala Gly Thr Asp Val Ala Lys Glu Ala Ser Asp Ile Ile Leu
820 825 830
Thr Asp Asp Asn Phe Thr Ser Ile Val Lys Ala Val Met Trp Gly Arg
835 840 845
Asn Val Tyr Asp Ser Ile Ser Lys Phe Leu Gln Phe Gln Leu Thr Val
850 855 860
Asn Val Val Ala Val Ile Val Ala Phe Thr Gly Ala Cys Ile Thr Gln
865 870 875 880
Asp Ser Pro Leu Lys Ala Val Gln Met Leu Trp Val Asn Leu Ile Met
885 890 895
Asp Thr Phe Ala Ser Leu Ala Leu Ala Thr Glu Pro Pro Thr Glu Ser
900 905 910
Leu Leu Leu Arg Lys Pro Tyr Gly Arg Asp Lys Pro Leu Ile Ser Arg
915 920 925
Thr Met Met Lys Asn Ile Leu Gly His Ala Val Tyr Gln Leu Thr Ile
930 935 940
Ile Phe Thr Leu Leu Phe Val Gly Glu Leu Phe Phe Asp Ile Asp Ser
945 950 955 960
Gly Arg Asn Ala Pro Leu His Ser Pro Pro Ser Glu His Tyr Thr Ile
965 970 975
Ile Phe Asn Thr Phe Val Met Met Gln Leu Phe Asn Glu Val Asn Ala
980 985 990
Arg Lys Ile His Gly Glu Arg Asn Val Phe His Gly Ile Phe Ser Asn
995 1000 1005
Pro Ile Phe Cys Ala Ile Val Leu Gly Thr Phe Ala Ile Gln Ile Val
1010 1015 1020
Ile Val Gln Phe Gly Gly Lys Pro Phe Ser Cys Ser Pro Leu Ser Thr
1025 1030 1035 1040
Glu Gln Trp Leu Trp Cys Leu Phe Val Gly Val Gly Glu Leu Val Trp
1045 1050 1055
Gly Gln Val Ile Ala Thr Ile Pro Thr Ser Gln Leu Lys Cys Leu Lys
1060 1065 1070
Glu Ala Gly His Gly Pro Gly Lys Asp Glu Met Ala Asp Glu Glu Leu
1075 1080 1085
Ala Glu Gly Glu Glu Glu Ile Asp His Ala Glu Arg Glu Leu Arg Arg
1090 1095 1100
Gly Gln Ile Leu Trp Phe Arg Gly Leu Asn Arg Ile Gln Thr Gln Met
1105 1110 1115 1120
Glu Val Val Ser Thr Phe Lys Arg Ser Gly Ser Phe Gln Gly Ala Val
1125 1130 1135
Arg Arg Arg Ser Ser Val Leu Ser Gln Leu His Asp Ile Arg Val Val
1140 1145 1150
Lys Ala Phe Arg Ser Ser Leu Tyr Glu Gly Leu Glu Lys Pro Glu Ser
1155 1160 1165
Lys Thr Ser Ile His Asn Phe Met Ala Thr Pro Glu Phe Leu Ile Asn
1170 1175 1180
Asp Tyr Thr His Asn Ile Pro Leu Ile Asp Asp Thr Asp Val Asp Glu
1185 1190 1195 1200
Asn Glu Asp Arg Leu Arg Ala Pro Pro Pro Pro Ser Pro Asn Gln Asn
1205 1210 1215
Asn Asn Ala Ile Asp Ser Gly Ile Tyr Leu Thr Thr His Gly Thr Lys
1220 1225 1230
Ser Ala Thr Ser Ser Val Pro Gly Ser Pro Leu His Ser Val Glu Thr
1235 1240 1245
Ser Leu
1250
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<211>369
<212>PRT
<213>马
<400>200
Met Val Leu Glu Val Ser Glu His Gln Val Phe Gln Asp Ser Glu Leu
1 5 10 15
Ala Phe Leu Leu Glu Asn Cys Ser Ser Ser Tyr Asp Tyr Leu Gly Glu
20 25 30
Asn Glu Ser Asp Thr Cys Cys Ala Ser Pro Pro Cys Pro Gln Asp Phe
35 40 45
Ser Leu Asn Phe Asp Arg Ala Phe Leu Pro Ala Leu Tyr Gly Leu Leu
50 55 60
Phe Val Leu Gly Leu Leu Gly Asn Gly Ala Val Ala Ala Val Leu Leu
65 70 75 80
Ser Gln Arg Ala Ala Leu Ser Ser Thr Asp Thr Phe Leu Leu His Leu
85 90 95
Ala Val Ala Asp Ala Leu Leu Val Leu Thr Leu Pro Leu Trp Ala Val
100 105 110
Asp Ala Ala Val Gln Trp Val Phe Gly Ser Gly Leu Cys Lys Val Ala
115 120 125
Gly Ala Leu Phe Asn Ile Asn Phe Tyr Ala Gly Ala Leu Leu Leu Ala
130 135 140
Cys Ile Ser Phe Asp Arg Tyr Leu Ser Ile Val His Ala Thr Gln Leu
145 150 155 160
Tyr Arg Arg Gly Pro Pro Thr Arg Val Ala Leu Thr Cys Val Val Val
165 170 175
Trp Gly Leu Cys Leu Leu Phe Ala Leu Pro Asp Phe Ile Phe Leu Ser
180 185 190
Ala His Arg Asp Glu Arg Leu Asn Ala Thr His Cys Gln Tyr Asn Phe
195 200 205
Pro Gln Val Gly Arg Thr Ala Leu Arg Val Leu Gln Leu Val Ala Gly
210 215 220
Phe Leu Leu Pro Leu Leu Val Met Ala Tyr Cys Tyr Ala Arg Ile Leu
225 230 235 240
Ala Val Leu Leu Val Ser Arg Gly Gln Arg Arg Leu Arg Ala Met Arg
245 250 255
Leu Val Val Val Val Val Val Ala Phe Ala Leu Cys Trp Thr Pro Tyr
260 265 270
Tyr Leu Val Met Leu Val Asp Thr Leu Met Asp Leu Gly Ala Leu Ala
275 280 285
Arg Asn Cys Gly Arg Glu Ser His Val Asp Val Ala Lys Ser Val Thr
290 295 300
Ser Gly Leu Gly Tyr Met His Cys Cys Leu Asn Pro Leu Leu Tyr Ala
305 310 315 320
Phe Val Gly Val Lys Phe Arg Glu Arg Met Trp Met Leu Leu Met Arg
325 330 335
Leu Gly Cys Pro Asp Gln Lys Gly His Gln Arg Gln Pro Pro Ser Cys
340 345 350
Arg Arg Asp Ser Ser Trp Ser Glu Thr Thr Glu Ala Ser Tyr Ser Gly
355 360 365
Leu
<210>201
<211>732
<212>PRT
<213>人
<400>201
Met Glu Gly Gly Asp Gln Ser Glu Glu Glu Pro Arg Glu Arg Ser Gln
1 5 10 15
Ala Gly Gly Met Gly Thr Leu Trp Ser Gln Glu Ser Thr Pro Glu Glu
20 25 30
Arg Leu Pro Val Glu Gly Ser Arg Pro Trp Ala Val Ala Arg Arg Val
35 40 45
Leu Thr Ala Ile Leu Ile Leu Gly Leu Leu Leu Cys Phe Ser Val Leu
50 55 60
Leu Phe Tyr Asn Phe Gln Asn Cys Gly Pro Arg Pro Cys Glu Thr Ser
65 70 75 80
Val Cys Leu Asp Leu Arg Asp His Tyr Leu Ala Ser Gly Asn Thr Ser
85 90 95
Val Ala Pro Cys Thr Asp Phe Phe Ser Phe Ala Cys Gly Arg Ala Lys
100 105 110
Glu Thr Asn Asn Ser Phe Gln Glu Leu Ala Thr Lys Asn Lys Asn Arg
115 120 125
Leu Arg Arg Ile Leu Glu Val Gln Asn Ser Trp His Pro Gly Ser Gly
130 135 140
Glu Glu Lys Ala Phe Gln Phe Tyr Asn Ser Cys Met Asp Thr Leu Ala
145 150 155 160
Ile Glu Ala Ala Gly Thr Gly Pro Leu Arg Gln Val Ile Glu Glu Leu
165 170 175
Gly Gly Trp Arg Ile Ser Gly Lys Trp Thr Ser Leu Asn Phe Asn Arg
180 185 190
Thr Leu Arg Leu Leu Met Ser Gln Tyr Gly His Phe Pro Phe Phe Arg
195 200 205
Ala Tyr Leu Gly Pro His Pro Ala Ser Pro His Thr Pro Val Ile Gln
210 215 220
Ile Asp Gln Pro Glu Phe Asp Val Pro Leu Lys Gln Asp Gln Glu Gln
225 230 235 240
Lys Ile Tyr Ala Gln Ile Phe Arg Glu Tyr Leu Thr Tyr Leu Asn Gln
245 250 255
Leu Gly Thr Leu Leu Gly Gly Asp Pro Ser Lys Val Gln Glu His Ser
260 265 270
Ser Leu Ser Ile Ser Ile Thr Ser Arg Leu Phe Gln Phe Leu Arg Pro
275 280 285
Leu Glu Gln Arg Arg Ala Gln Gly Lys Leu Phe Gln Met Val Thr Ile
290 295 300
Asp Gln Leu Lys Glu Met Ala Pro Ala Ile Asp Trp Leu Ser Cys Leu
305 310 315 320
Gln Ala Thr Phe Thr Pro Met Ser Leu Ser Pro Ser Gln Ser Leu Val
325 330 335
Val His Asp Val Glu Tyr Leu Lys Asn Met Ser Gln Leu Val Glu Glu
340 345 350
Met Leu Leu Lys Gln Arg Asp Phe Leu Gln Ser His Met Ile Leu Gly
355 360 365
Leu Val Val Thr Leu Ser Pro Ala Leu Asp Ser Gln Phe Gln Glu Ala
370 375 380
Arg Arg Lys Leu Ser Gln Lys Leu Arg Glu Leu Thr Glu Gln Pro Pro
385 390 395 400
Met Pro Ala Arg Pro Arg Trp Met Lys Cys Val Glu Glu Thr Gly Thr
405 410 415
Phe Phe Glu Pro Thr Leu Ala Ala Leu Phe Val Arg Glu Ala Phe Gly
420 425 430
Pro Ser Thr Arg Ser Ala Ala Met Lys Leu Phe Thr Ala Ile Arg Asp
435 440 445
Ala Leu Ile Thr Arg Leu Arg Asn Leu Pro Trp Met Asn Glu Glu Thr
450 455 460
Gln Asn Met Ala Gln Asp Lys Val Ala Gln Leu Gln Val Glu Met Gly
465 470 475 480
Ala Ser Glu Trp Ala Leu Lys Pro Glu Leu Ala Arg Gln Glu Tyr Asn
485 490 495
Asp Ile Gln Leu Gly Ser Ser Phe Leu Gln Ser Val Leu Ser Cys Val
500 505 510
Arg Ser Leu Arg Ala Arg Ile Val Gln Ser Phe Leu Gln Pro His Pro
515 520 525
Gln His Arg Trp Lys Val Ser Pro Trp Asp Val Asn Ala Tyr Tyr Ser
530 535 540
Val Ser Asp His Val Val Val Phe Pro Ala Gly Leu Leu Gln Pro Pro
545 550 555 560
Phe Phe His Pro Gly Tyr Pro Arg Ala Val Asn Phe Gly Ala Ala Gly
565 570 575
Ser Ile Met Ala His Glu Leu Leu His Ile Phe Tyr Gln Leu Leu Leu
580 585 590
Pro Gly Gly Cys Leu Ala Cys Asp Asn His Ala Leu Gln Glu Ala His
595 600 605
Leu Cys Leu Lys Arg His Tyr Ala Ala Phe Pro Leu Pro Ser Arg Thr
610 615 620
Ser Phe Asn Asp Ser Leu Thr Phe Leu Glu Asn Ala Ala Asp Val Gly
625 630 635 640
Gly Leu Ala Ile Ala Leu Gln Ala Tyr Ser Lys Arg Leu Leu Arg His
645 650 655
His Gly Glu Thr Val Leu Pro Ser Leu Asp Leu Ser Pro Gln Gln Ile
660 665 670
Phe Phe Arg Ser Tyr Ala Gln Val Met Cys Arg Lys Pro Ser Pro Gln
675 680 685
Asp Ser His Asp Thr His Ser Pro Pro His Leu Arg Val His Gly Pro
690 695 700
Leu Ser Ser Thr Pro Ala Phe Ala Arg Tyr Phe Arg Cys Ala Arg Gly
705 710 715 720
Ala Leu Leu Asn Pro Ser Ser Arg Cys Gln Leu Trp
725 730
<210>202
<211>2545
<212>DNA
<213>人
<400>202
gggaggagaa gcctgggtgc cccccactga taagcaggct ccacccagag gccagtcctg 60
tgtgtctggg gacaaggcga aagagcagca gaagtgcccc ttctccagga tcaaggaact 120
ggggcggggg gtgtttcctg gaccccagtc ctccgaatca gctcctagag tggaaccagg 180
aaggattctg gagccacaga agatagacag atggaaggtg gggaccaaag tgaggaagag 240
ccgagggaac gcagccaggc aggtggaatg ggaactctct ggagccaaga gagcactcca 300
gaagagaggc tgcccgtgga agggagcagg ccatgggcag tggccaggcg ggtgctgaca 360
gctatcctga ttttgggcct gctcctttgt ttttctgtgc ttttgttcta caacttccag 420
aactgtggcc ctcgcccctg tgagacatct gtgtgtttgg atctccggga tcattacctg 480
gcctctggga acacaagtgt ggccccctgc accgacttct tcagctttgc ctgtggaagg 540
gccaaagaga ccaataattc ttttcaggag cttgccacaa agaacaaaaa ccgacttcgg 600
agaatactgg aggtccagaa ttcctggcac ccaggctctg gggaggagaa agccttccag 660
ttctacaact cctgcatgga tacacttgcc attgaagctg cagggactgg tcccctcaga 720
caagttattg aggagcttgg aggctggcgc atctctggta aatggacttc cttaaacttt 780
aaccgaacgc tgagacttct gatgagtcag tatggccatt tccctttctt cagagcctac 840
ctaggacctc atcctgcctc tccacacaca ccagtcatcc agatagacca gccagagttt 900
gatgttcccc tcaagcaaga tcaagaacag aagatctatg cccagatctt tcgggaatac 960
ctgacttacc tgaatcagct gggaaccttg ctgggaggag acccaagcaa ggtgcaagaa 1020
cactcttcct tgtcaatctc catcacttca cggctgttcc agtttctgag gcccctggag 1080
cagcggcggg cacagggcaa gctcttccag atggtcacta tcgaccagct caaggaaatg 1140
gcccccgcca tcgactggtt gtcctgcttg caagcgacat tcacaccgat gtccctgagc 1200
ccttctcagt ccctcgtggt ccatgacgtg gaatatttga aaaacatgtc acaactggtg 1260
gaggagatgc tgctaaagca gagggacttt ctgcagagcc acatgatctt agggctggtg 1320
gtgacccttt ctccagccct ggacagtcaa ttccaggagg cacgcagaaa gctcagccag 1380
aaactgcggg aactgacaga gcaaccaccc atgcctgccc gcccacgatg gatgaagtgc 1440
gtggaggaga caggcacgtt cttcgagccc acgctggcgg ctttgtttgt tcgtgaggcc 1500
tttggcccga gcacccgaag tgctgccatg aaattattca ctgcgatccg ggatgccctc 1560
atcactcgcc tcagaaacct tccctggatg aatgaggaga cccagaacat ggcccaggac 1620
aaggttgctc aactgcaggt ggagatgggg gcttcagaat gggccctgaa gccagagctg 1680
gcccgacaag aatacaacga tatacagctt ggatcgagct tcctgcagtc tgtcctgagc 1740
tgtgtccggt ccctccgagc tagaattgtc cagagcttct tgcagcctca cccccaacac 1800
aggtggaagg tgtccccttg ggacgtcaat gcttactatt cggtatctga ccatgtggta 1860
gtctttccag ctggactcct ccaaccccca ttcttccacc ctggctatcc cagagccgtg 1920
aactttggcg ctgctggcag catcatggcc cacgagctgt tgcacatctt ctaccagctc 1980
ttactgcctg ggggctgcct cgcctgtgac aaccatgccc tccaggaagc tcacctgtgc 2040
ctgaagcgcc attatgctgc ctttccatta cctagcagaa cctccttcaa tgactccctc 2100
acattcttag agaatgctgc agacgttggg gggctagcca tcgcgctgca ggcatacagc 2160
aagaggctgt tacggcacca tggggagact gtcctgccca gcctggacct cagcccccag 2220
cagatcttct ttcgaagcta tgcccaggtg atgtgtagga agcccagccc ccaggactct 2280
cacgacactc acagccctcc acacctccga gtccacgggc ccctcagcag caccccagcc 2340
tttgccaggt atttccgctg tgcacgtggt gctctcttga acccctccag ccgctgccag 2400
ctctggtaac ttggttacca aagatgccac agcacagaaa tatcgaccaa cacctccctg 2460
gtcacatcca tggaatcaga gcaagatttc ctttctgctt ctgttccaaa aataaaagct 2520
ggcacttggc ttccgcttgt ctctt 2545
Claims (18)
1.一种用于分离精液样品中携带X-染色体和Y-染色体的精子的方法，所述方法包括：
(a)使所述精液样品与至少一种特异性结合X-染色体或Y-染色体特异性抗原的结合剂接触一定时间，所述接触时间足以在结合剂和携带X-染色体或Y-染色体的精子之间形成缀合物；和
(b)分离抗体-精子缀合物与未结合的精子，
其中所述X-染色体或Y-染色体特异性抗原包含选自以下的序列：(i)SEQ ID NO：1-21、43-89、138、140、142、144、146、148、150、152、154、156、158、160、162、164和183-201；(ii)与SEQ IDNO：1-21、43-89、138、140、142、144、146、148、150、152、154、156、158、160、162、164和183-201的序列具有至少85％、90％或95％同一性的序列；和(iii)由在严格杂交条件下与SEQ ID NO：22-42、90-136、137、139、141、143、145、147、149、151、153、155、157、159、161、163、165-182或202的序列杂交的多核苷酸序列编码的序列。
2.权利要求1的方法，其中所述结合剂为抗体或其抗原结合片段。
3.权利要求2的方法，其中所述结合剂为Fab或scFv。
4.权利要求2的方法，其中所述抗体选自说明书表1中标示出的抗体。
5.权利要求1-4中任一项的方法，其中所述结合剂结合在固体支持体上。
6.权利要求1-5中任一项的方法，其中所述结合剂提供在一个或多个磁珠的表面上，并通过施加磁场分离抗体-精子缀合物和未结合的精子。
7.权利要求1-6中任一项的方法，其中步骤(b)包括使精液样品与特异性结合所述特异性结合X-染色体或Y-染色体特异性抗原的结合剂的第二种结合剂接触，并且所述第二种结合剂固定在基体上。
8.权利要求1-7中任一项的方法，其中提供具有蛋白酶识别位点的结合剂，所述方法进一步包括使所述抗体-精子缀合物在与未结合的精子分离后与蛋白酶接触，从而由抗体-精子缀合物释放出分离的精子。
9.权利要求1-8中任一项的方法，其中由所述精液样品富集携带X-染色体的精子。
10.一种用于分离精液样品中携带X-染色体和Y-染色体的精子的试剂盒，所述试剂盒包含：
(a)装有至少一种对X-染色体或Y-染色体特异性抗原具有特异性的结合剂的容器，其中所述X-染色体或Y-染色体特异性抗原包含选自以下的序列：(i)SEQ ID NO：1-21、43-89、138、140、142、144、146、148、150、152、154、156、158、160、162、164和183-201；(ii)与SEQ ID NO：1-21、43-89、138、140、142、144、146、148、150、152、154、156、158、160、162、164和183-201的序列具有至少85％、90％或95％同一性的序列；和(iii)由在严格杂交条件下与SEQ ID NO：22-42、90-136、137、139、141、143、145、147、149、151、153、155、157、159、161、163、165-182或202的序列杂交的多核苷酸序列编码的序列；和
(b)使用所述试剂盒的说明书。
11.权利要求10的试剂盒，所述结合剂为抗体或其抗原结合片段。
12.权利要求11的试剂盒，其中所述结合剂为Fab或scFv。
13.权利要求11的试剂盒，其中所述抗体选自说明书表1中标示出的抗体。
14.权利要求10-13中任一项的试剂盒，其中所述结合剂结合在固体支持体上。
15.权利要求10-14中任一项的试剂盒，其中所述结合剂提供在一个或多个磁珠的表面上。
16.一种组合物，所述组合物包含按照权利要求中1-9任一项的方法制备的分离精子。
17.一种用于富集精液样品中的携带X-染色体或Y-染色体的精子的方法，所述方法包括使精液样品与至少一种特异性结合X-染色体或Y-染色体特异性抗原的结合剂接触一定时间，所述接触时间足以在所述结合剂和携带X-染色体或Y-染色体的精子之间形成缀合物，其中所述携带X-染色体或Y-染色体的精子与所述结合剂的结合有效降低所述精子的活动率和活力中的至少一种，且其中所述X-染色体或Y-染色体特异性抗原包含选自以下的序列：(i)SEQ ID NO：1-21、43-89、138、140、142、144、146、148、150、152、154、156、158、160、162、164和183-201；(ii)与SEQ ID NO：1-21、43-89、138、140、142、144、146、148、150、152、154、156、158、160、162、164和183-201的序列具有至少85％、90％或95％同一性的序列；和(iii)由在严格杂交条件下与SEQ ID NO：22-42、90-136、137、139、141、143、145、147、149、151、153、155、157、159、161、163、165-182或202的序列杂交的多核苷酸序列编码的序列。
18.权利要求17的方法，其中所述结合剂与细胞毒素结合。
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| PCT/NZ2008/000177 WO2009014456A1 (en) | 2007-07-23 | 2008-07-23 | Materials and methods for sperm sex selection |
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| US (1) | US20090208977A1 (zh) |
| EP (1) | EP2181331A1 (zh) |
| CN (1) | CN101821623A (zh) |
| AU (1) | AU2008279893A1 (zh) |
| BR (1) | BRPI0814343A2 (zh) |
| CA (1) | CA2692006A1 (zh) |
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| WO (1) | WO2009014456A1 (zh) |
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| CN115785203A (zh) * | 2022-06-10 | 2023-03-14 | 河北博海生物工程开发有限公司 | 肺癌特异性分子靶标10及其用途 |
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| US20040142384A1 (en) * | 2003-01-16 | 2004-07-22 | Cohen Barb Ariel | Magnetic separator |
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2008
- 2008-07-23 BR BRPI0814343A patent/BRPI0814343A2/pt not_active IP Right Cessation
- 2008-07-23 US US12/178,531 patent/US20090208977A1/en not_active Abandoned
- 2008-07-23 AU AU2008279893A patent/AU2008279893A1/en not_active Abandoned
- 2008-07-23 CN CN200880108067A patent/CN101821623A/zh active Pending
- 2008-07-23 EP EP08793939A patent/EP2181331A1/en not_active Withdrawn
- 2008-07-23 CA CA002692006A patent/CA2692006A1/en not_active Abandoned
- 2008-07-23 WO PCT/NZ2008/000177 patent/WO2009014456A1/en active Application Filing
- 2008-07-23 MX MX2010000680A patent/MX2010000680A/es not_active Application Discontinuation
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| US4448767A (en) * | 1977-10-11 | 1984-05-15 | Sumar Corporation | Preparation of monospecific male-specific antibody and the use thereof for increasing the percentage of mammalian offspring of either sex |
| WO1997007399A1 (en) * | 1995-08-11 | 1997-02-27 | University Of Guelph | Method for identifying sex specific and species specific molecules, molecules identified using the method, and uses of the molecules |
| US6153373A (en) * | 1997-07-01 | 2000-11-28 | Vicam, L.P. | Method for sex determination of mammalian offspring |
| WO2001042283A2 (en) * | 1999-12-07 | 2001-06-14 | University Of Guelph | Sex-chromosome-specific proteins, species specific and sperm specific proteins and methods for their identification and isolation |
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108290938A (zh) * | 2015-07-13 | 2018-07-17 | 努里塞恩斯有限公司 | 用于确定精子性别的抗体及其用途 |
| CN106544411A (zh) * | 2016-08-27 | 2017-03-29 | 华中农业大学 | 一种利用标识蛋白分析鉴定哺乳动物y精子分型的方法 |
| CN114137231A (zh) * | 2022-01-29 | 2022-03-04 | 北京大有天弘科技有限公司 | 一种血型不规则抗体的检测试剂盒及其应用 |
| CN114137231B (zh) * | 2022-01-29 | 2022-04-29 | 北京大有天弘科技有限公司 | 一种血型不规则抗体的检测试剂盒及其应用 |
| CN115785203A (zh) * | 2022-06-10 | 2023-03-14 | 河北博海生物工程开发有限公司 | 肺癌特异性分子靶标10及其用途 |
| CN115785203B (zh) * | 2022-06-10 | 2024-03-12 | 河北博海生物工程开发有限公司 | 肺癌特异性分子靶标10及其用途 |
Also Published As
| Publication number | Publication date |
|---|---|
| AU2008279893A1 (en) | 2009-01-29 |
| CA2692006A1 (en) | 2009-01-29 |
| US20090208977A1 (en) | 2009-08-20 |
| WO2009014456A1 (en) | 2009-01-29 |
| EP2181331A1 (en) | 2010-05-05 |
| MX2010000680A (es) | 2010-06-01 |
| BRPI0814343A2 (pt) | 2017-10-03 |
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