CN101821256A - 作为mGlu5拮抗剂的新型杂环化合物 - Google Patents

作为mGlu5拮抗剂的新型杂环化合物 Download PDF

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Publication number
CN101821256A
CN101821256A CN200880101389A CN200880101389A CN101821256A CN 101821256 A CN101821256 A CN 101821256A CN 200880101389 A CN200880101389 A CN 200880101389A CN 200880101389 A CN200880101389 A CN 200880101389A CN 101821256 A CN101821256 A CN 101821256A
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pyridyl
piperidines
methyl
propargyl
nitro
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English (en)
Chinese (zh)
Inventor
A·莱奥纳蒂
G·莫塔
C·里瓦
E·波基斯
D·格拉齐安尼
M·M·隆格希
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Recordati Ireland Ltd
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Recordati Ireland Ltd
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/08—Drugs for disorders of the urinary system of the prostate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/10—Drugs for disorders of the urinary system of the bladder
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Urology & Nephrology (AREA)
  • Pain & Pain Management (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
CN200880101389A 2007-08-02 2008-08-01 作为mGlu5拮抗剂的新型杂环化合物 Pending CN101821256A (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US95367707P 2007-08-02 2007-08-02
US60/953,677 2007-08-02
US4517508P 2008-04-15 2008-04-15
US61/045,175 2008-04-15
PCT/EP2008/006351 WO2009015897A1 (en) 2007-08-02 2008-08-01 Novel heterocyclic compounds as mglu5 antagonists

Publications (1)

Publication Number Publication Date
CN101821256A true CN101821256A (zh) 2010-09-01

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ID=39885225

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CN200880101389A Pending CN101821256A (zh) 2007-08-02 2008-08-01 作为mGlu5拮抗剂的新型杂环化合物

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US (1) US8518916B2 (https=)
EP (1) EP2178858B1 (https=)
JP (1) JP5412430B2 (https=)
KR (1) KR20100052507A (https=)
CN (1) CN101821256A (https=)
AT (1) ATE539075T1 (https=)
AU (1) AU2008282032B2 (https=)
BR (1) BRPI0814182A2 (https=)
CA (1) CA2694359A1 (https=)
CY (1) CY1112500T1 (https=)
DK (1) DK2178858T3 (https=)
EA (1) EA018328B1 (https=)
ES (1) ES2380165T3 (https=)
HR (1) HRP20120225T1 (https=)
IL (1) IL203659A (https=)
NZ (1) NZ582934A (https=)
PL (1) PL2178858T3 (https=)
PT (1) PT2178858E (https=)
RS (1) RS52167B (https=)
SI (1) SI2178858T1 (https=)
WO (1) WO2009015897A1 (https=)
ZA (1) ZA201001467B (https=)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102827056A (zh) * 2012-09-03 2012-12-19 华东理工大学 N-芳基取代吡咯烷酮衍生物及其用途
US8937148B2 (en) 2012-09-07 2015-01-20 Empire Technology Development LLP Regioregular copolymers and methods for making same
CN111094269A (zh) * 2017-06-29 2020-05-01 瑞蔻达蒂化学制药公司 杂环亚甲基衍生物及其作为mGluR5受体调节剂的用途

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2010089119A1 (en) * 2009-02-04 2010-08-12 Recordati Ireland Limited Heterocyclic derivatives as m-glu5 antagonists
US20120028931A1 (en) * 2009-09-14 2012-02-02 Recordati Ireland Limited Heterocyclic m-glu5 antagonists
WO2012085166A1 (en) * 2010-12-22 2012-06-28 Merz Pharma Gmbh & Co. Kgaa Metabotropic glutamate receptor modulators
AR084515A1 (es) * 2010-12-22 2013-05-22 Merz Pharma Gmbh & Co Kgaa Derivados heterociclicos nitrogenados, composiciones farmaceuticas que los contienen y uso de los mismos en el tratamiento de enfermedades asociadas al sistema nervioso central tales como parkinson y alzheimer, entre otras
CN104011016B (zh) * 2011-12-27 2016-08-17 帝斯曼知识产权资产管理有限公司 维生素a中间体的催化合成
AU2014211727B2 (en) * 2013-02-04 2018-07-26 Prexton Therapeutics Sa Positive allosteric modulators of mGluR3

Citations (15)

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EP0537993A1 (en) * 1991-10-17 1993-04-21 Eli Lilly And Company Nicotinic activity of a series of arecolones and isoarecolones
WO2001002386A1 (en) * 1999-07-01 2001-01-11 Mediolanum Farmaceutici S.P.A. SELECTIVE M2 MUSCARINIC RECEPTOR ANTAGONISTS HAVING 5H-DIBENZ[b,f]AZEPINE STRUCTURE
US6265434B1 (en) * 1999-04-06 2001-07-24 Merck & Co., Inc. Pyrrolidine modulators of chemokine receptor activity
WO2003093236A1 (en) * 2002-05-02 2003-11-13 Euro-Celtique, S.A. 1-(pyrid-2-yl)-piperazine compounds as metabotropic glutamate receptor inhibitor
WO2004020435A1 (en) * 2002-08-16 2004-03-11 Janssen Pharmaceutica N.V. Piperidinyl compounds that selectively bind integrins
US20040077671A1 (en) * 1999-04-01 2004-04-22 Chu-Moyer Margaret Y. Sorbitol dehydrogenase inhibitors
WO2004069158A2 (en) * 2003-01-27 2004-08-19 Merck & Co., Inc. Substituted pyrazoles, compositions containing such compounds and methods of use
US20040186292A1 (en) * 2002-05-28 2004-09-23 Tao Wang Indole, azaindole and related heterocyclic 4-alkenyl piperidine amides
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US6265434B1 (en) * 1999-04-06 2001-07-24 Merck & Co., Inc. Pyrrolidine modulators of chemokine receptor activity
WO2001002386A1 (en) * 1999-07-01 2001-01-11 Mediolanum Farmaceutici S.P.A. SELECTIVE M2 MUSCARINIC RECEPTOR ANTAGONISTS HAVING 5H-DIBENZ[b,f]AZEPINE STRUCTURE
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US20040186292A1 (en) * 2002-05-28 2004-09-23 Tao Wang Indole, azaindole and related heterocyclic 4-alkenyl piperidine amides
WO2004020435A1 (en) * 2002-08-16 2004-03-11 Janssen Pharmaceutica N.V. Piperidinyl compounds that selectively bind integrins
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WO2005090347A1 (fr) * 2004-02-26 2005-09-29 Sanofi-Aventis Derives d’aryl- et d’heteroaryl-piperidinecarboxylates, leur preparation et leur application comme inhibiteurs de l'enzyme faah
WO2006089700A1 (en) * 2005-02-22 2006-08-31 Novartis Ag Pyrrolidine and piperidine acetylene derivatives for use as mglur5 antagonists
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Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102827056A (zh) * 2012-09-03 2012-12-19 华东理工大学 N-芳基取代吡咯烷酮衍生物及其用途
CN102827056B (zh) * 2012-09-03 2014-07-23 华东理工大学 N-芳基取代吡咯烷酮衍生物及其用途
US8937148B2 (en) 2012-09-07 2015-01-20 Empire Technology Development LLP Regioregular copolymers and methods for making same
US9181287B2 (en) 2012-09-07 2015-11-10 Empire Technology Development Llc Regioregular copolymers and methods for making same
CN111094269A (zh) * 2017-06-29 2020-05-01 瑞蔻达蒂化学制药公司 杂环亚甲基衍生物及其作为mGluR5受体调节剂的用途

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DK2178858T3 (da) 2012-03-19
EP2178858A1 (en) 2010-04-28
JP2010535165A (ja) 2010-11-18
CY1112500T1 (el) 2015-12-09
WO2009015897A1 (en) 2009-02-05
NZ582934A (en) 2011-10-28
BRPI0814182A2 (pt) 2015-01-27
EA201000283A1 (ru) 2010-06-30
ES2380165T3 (es) 2012-05-09
RS52167B (sr) 2012-08-31
AU2008282032A1 (en) 2009-02-05
ATE539075T1 (de) 2012-01-15
CA2694359A1 (en) 2009-02-05
HK1141788A1 (en) 2010-11-19
ZA201001467B (en) 2010-11-24
EA018328B1 (ru) 2013-07-30
US20090042841A1 (en) 2009-02-12
JP5412430B2 (ja) 2014-02-12
EP2178858B1 (en) 2011-12-28
KR20100052507A (ko) 2010-05-19
US8518916B2 (en) 2013-08-27
HRP20120225T1 (hr) 2012-04-30
SI2178858T1 (sl) 2012-03-30
IL203659A (en) 2013-06-27
AU2008282032B2 (en) 2014-08-07
PT2178858E (pt) 2012-02-24
PL2178858T3 (pl) 2012-07-31

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