DK2178858T3 - Nye heterocycliske forbindelser som mGlu5-antagonister - Google Patents
Nye heterocycliske forbindelser som mGlu5-antagonisterInfo
- Publication number
- DK2178858T3 DK2178858T3 DK08785292.7T DK08785292T DK2178858T3 DK 2178858 T3 DK2178858 T3 DK 2178858T3 DK 08785292 T DK08785292 T DK 08785292T DK 2178858 T3 DK2178858 T3 DK 2178858T3
- Authority
- DK
- Denmark
- Prior art keywords
- heterocyclic compounds
- novel heterocyclic
- mglu5 antagonists
- treatment
- mglu5
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/08—Drugs for disorders of the urinary system of the prostate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/10—Drugs for disorders of the urinary system of the bladder
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Urology & Nephrology (AREA)
- Pain & Pain Management (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Hydrogenated Pyridines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US95367707P | 2007-08-02 | 2007-08-02 | |
| US4517508P | 2008-04-15 | 2008-04-15 | |
| PCT/EP2008/006351 WO2009015897A1 (en) | 2007-08-02 | 2008-08-01 | Novel heterocyclic compounds as mglu5 antagonists |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK2178858T3 true DK2178858T3 (da) | 2012-03-19 |
Family
ID=39885225
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK08785292.7T DK2178858T3 (da) | 2007-08-02 | 2008-08-01 | Nye heterocycliske forbindelser som mGlu5-antagonister |
Country Status (23)
| Country | Link |
|---|---|
| US (1) | US8518916B2 (da) |
| EP (1) | EP2178858B1 (da) |
| JP (1) | JP5412430B2 (da) |
| KR (1) | KR20100052507A (da) |
| CN (1) | CN101821256A (da) |
| AT (1) | ATE539075T1 (da) |
| AU (1) | AU2008282032B2 (da) |
| BR (1) | BRPI0814182A2 (da) |
| CA (1) | CA2694359A1 (da) |
| CY (1) | CY1112500T1 (da) |
| DK (1) | DK2178858T3 (da) |
| EA (1) | EA018328B1 (da) |
| ES (1) | ES2380165T3 (da) |
| HK (1) | HK1141788A1 (da) |
| HR (1) | HRP20120225T1 (da) |
| IL (1) | IL203659A (da) |
| NZ (1) | NZ582934A (da) |
| PL (1) | PL2178858T3 (da) |
| PT (1) | PT2178858E (da) |
| RS (1) | RS52167B (da) |
| SI (1) | SI2178858T1 (da) |
| WO (1) | WO2009015897A1 (da) |
| ZA (1) | ZA201001467B (da) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8937148B2 (en) | 2012-09-07 | 2015-01-20 | Empire Technology Development LLP | Regioregular copolymers and methods for making same |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2010089119A1 (en) * | 2009-02-04 | 2010-08-12 | Recordati Ireland Limited | Heterocyclic derivatives as m-glu5 antagonists |
| US20120028931A1 (en) * | 2009-09-14 | 2012-02-02 | Recordati Ireland Limited | Heterocyclic m-glu5 antagonists |
| WO2012085166A1 (en) * | 2010-12-22 | 2012-06-28 | Merz Pharma Gmbh & Co. Kgaa | Metabotropic glutamate receptor modulators |
| WO2012085167A1 (en) * | 2010-12-22 | 2012-06-28 | Merz Pharma Gmbh & Co. Kgaa | Metabotropic glutamate receptor modulators |
| BR112014015982A8 (pt) * | 2011-12-27 | 2017-07-04 | Dsm Ip Assets Bv | síntese catalítica do intermediário da vitamina a |
| CN102827056B (zh) * | 2012-09-03 | 2014-07-23 | 华东理工大学 | N-芳基取代吡咯烷酮衍生物及其用途 |
| CA2899954A1 (en) | 2013-02-04 | 2014-08-07 | Merck Patent Gmbh | Positive allosteric modulators of mglur3 |
| MX2019015015A (es) * | 2017-06-29 | 2020-08-06 | Recordati Ind Chimica E Farmaceutica S P A | Derivados de heterociclilmetilideno y su uso como moduladores de los receptores de mglur5. |
Family Cites Families (32)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| USRE24826E (en) * | 1956-08-30 | 1960-05-17 | N-alkylpiperidyl alkynylamines | |
| JPS5995249A (ja) * | 1982-11-24 | 1984-06-01 | Ono Pharmaceut Co Ltd | ロイコトリエンｂ４類似化合物、その製造方法及びそれらを有効成分として含有する治療剤 |
| CA2080536A1 (en) * | 1991-10-17 | 1993-04-18 | John S. Ward | Nicotinic activity of a series of arecolones and isoarecolones |
| US5990114A (en) * | 1996-02-28 | 1999-11-23 | Recordati, S.A., Chemical And Pharmaceutical Company | Use of 5-HT1A receptor antagonists for the treatment of urinary incontinence |
| UA71951C2 (en) * | 1999-04-01 | 2005-01-17 | Pfizer Prod Inc | Pyrimidines as sorbitol dehydrogenase inhibitors, a pharmaceutical composition containing them, intermediate compounds and a method for the preparation of intermediate compound |
| US6265434B1 (en) * | 1999-04-06 | 2001-07-24 | Merck & Co., Inc. | Pyrrolidine modulators of chemokine receptor activity |
| TW593241B (en) | 1999-04-20 | 2004-06-21 | Hoffmann La Roche | Carbamic acid derivatives |
| ITMI991452A1 (it) * | 1999-07-01 | 2001-01-01 | Mediolanum Farmaceutici Srl | Antagonisti selettivi per i recettori m2 con struttura 5h-dibenzo b,fazepinica |
| US6306861B1 (en) * | 1999-07-30 | 2001-10-23 | Recordati S.A. Chemical And Pharmaceutical Company | Thienopyrancecarboxamide derivatives |
| US6387909B1 (en) * | 1999-07-30 | 2002-05-14 | Recordati S.A. Chemical And Pharmaceutical Company | Thienopyranecarboxamide derivatives |
| US6548522B1 (en) | 1999-10-12 | 2003-04-15 | Hoffmann-La Roche Inc. | Method for treating conditions related to the glutamate receptor using carboxylic acid amide derivatives |
| US6365591B1 (en) * | 1999-10-18 | 2002-04-02 | Recordati, S.A., Chemical And Pharmacueticals Company | Isoxazolecarboxamide derivatives |
| US6403594B1 (en) * | 1999-10-18 | 2002-06-11 | Recordati, S.A. Chemical And Pharmaceutical Company | Benzopyran derivatives |
| EP1230225A2 (en) | 1999-11-01 | 2002-08-14 | Eli Lilly And Company | Pharmaceutically active 4-substituted pyrimidine derivatives |
| CA2413330A1 (en) | 2000-06-28 | 2002-01-03 | Smithkline Beecham P.L.C. | Wet milling process |
| US6369222B1 (en) * | 2000-07-18 | 2002-04-09 | Hoffmann-La Roche Inc. | mGluR antagonists and a method for their synthesis |
| WO2003093236A1 (en) * | 2002-05-02 | 2003-11-13 | Euro-Celtique, S.A. | 1-(pyrid-2-yl)-piperazine compounds as metabotropic glutamate receptor inhibitor |
| US7348337B2 (en) * | 2002-05-28 | 2008-03-25 | Bristol-Myers Squibb Company | Indole, azaindole and related heterocyclic 4-alkenyl piperidine amides |
| US20040077684A1 (en) * | 2002-08-16 | 2004-04-22 | Bart De Corte | Piperidinyl compounds that selectively bind integrins |
| US7491737B2 (en) | 2002-10-30 | 2009-02-17 | Merck & Co., Inc. | Heterarylpiperidine modulators of chemokine receptor activity |
| EP1590336B1 (en) * | 2003-01-27 | 2010-12-01 | Merck Sharp & Dohme Corp. | Substituted pyrazoles, compositions containing such compounds and methods of use |
| ITMI20030151A1 (it) * | 2003-01-30 | 2004-07-31 | Recordati Ind Chimica E Farma Ceutica S P A | Uso di antagonisti selettivi del recettore mglu5 per il trattamento di disfunzioni neuromuscolari del tratto urinario inferiore. |
| US7338954B2 (en) * | 2003-09-17 | 2008-03-04 | Bristol-Myers Squibb Company | Compounds useful as motilin agonists and method |
| FR2866884B1 (fr) * | 2004-02-26 | 2007-08-31 | Sanofi Synthelabo | Derives d'aryl-et d'heteroaryl-piperidinecarboxylates, leur preparation et leur application en therapeutique |
| EP1740556A1 (en) | 2004-03-26 | 2007-01-10 | Rigel Pharmaceuticals, Inc. | Heterocyclic anti-viral compounds comprising metabolizable moieties and their uses |
| EP1740587A4 (en) * | 2004-04-02 | 2009-07-15 | Adenosine Therapeutics Llc | SELECTIVE ANTAGONISTS OF A2A ADENOSINE RECEPTORS |
| GB0503646D0 (en) * | 2005-02-22 | 2005-03-30 | Novartis Ag | Organic compounds |
| EP1863804A1 (en) * | 2005-04-01 | 2007-12-12 | Methylgene, Inc. | Inhibitors of histone deacetylase |
| GB0514296D0 (en) * | 2005-07-12 | 2005-08-17 | Novartis Ag | Organic compounds |
| ATE533485T1 (de) * | 2005-10-31 | 2011-12-15 | Merck Sharp & Dohme | Cetp-inhibitoren |
| JP5554988B2 (ja) * | 2006-04-07 | 2014-07-23 | メチルジーン インコーポレイテッド | ヒストンデアセチラーゼの阻害剤 |
| US7985754B2 (en) | 2006-07-17 | 2011-07-26 | Trovis Pharmaceuticals, Llc | Selective antagonists of A2A adenosine receptors |
-
2008
- 2008-08-01 BR BRPI0814182-7A2A patent/BRPI0814182A2/pt not_active IP Right Cessation
- 2008-08-01 AU AU2008282032A patent/AU2008282032B2/en not_active Expired - Fee Related
- 2008-08-01 CN CN200880101389A patent/CN101821256A/zh active Pending
- 2008-08-01 CA CA2694359A patent/CA2694359A1/en not_active Abandoned
- 2008-08-01 AT AT08785292T patent/ATE539075T1/de active
- 2008-08-01 EP EP08785292A patent/EP2178858B1/en active Active
- 2008-08-01 WO PCT/EP2008/006351 patent/WO2009015897A1/en active Application Filing
- 2008-08-01 EA EA201000283A patent/EA018328B1/ru not_active IP Right Cessation
- 2008-08-01 PL PL08785292T patent/PL2178858T3/pl unknown
- 2008-08-01 RS RS20120110A patent/RS52167B/en unknown
- 2008-08-01 SI SI200830533T patent/SI2178858T1/sl unknown
- 2008-08-01 PT PT08785292T patent/PT2178858E/pt unknown
- 2008-08-01 NZ NZ582934A patent/NZ582934A/en not_active IP Right Cessation
- 2008-08-01 JP JP2010518567A patent/JP5412430B2/ja not_active Expired - Fee Related
- 2008-08-01 KR KR1020107004641A patent/KR20100052507A/ko not_active Application Discontinuation
- 2008-08-01 ES ES08785292T patent/ES2380165T3/es active Active
- 2008-08-01 DK DK08785292.7T patent/DK2178858T3/da active
- 2008-08-04 US US12/185,639 patent/US8518916B2/en not_active Expired - Fee Related
-
2010
- 2010-02-02 IL IL203659A patent/IL203659A/en not_active IP Right Cessation
- 2010-03-01 ZA ZA2010/01467A patent/ZA201001467B/en unknown
- 2010-07-28 HK HK10107247.4A patent/HK1141788A1/xx not_active IP Right Cessation
-
2012
- 2012-03-12 HR HR20120225T patent/HRP20120225T1/hr unknown
- 2012-03-21 CY CY20121100296T patent/CY1112500T1/el unknown
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8937148B2 (en) | 2012-09-07 | 2015-01-20 | Empire Technology Development LLP | Regioregular copolymers and methods for making same |
| US9181287B2 (en) | 2012-09-07 | 2015-11-10 | Empire Technology Development Llc | Regioregular copolymers and methods for making same |
Also Published As
| Publication number | Publication date |
|---|---|
| SI2178858T1 (sl) | 2012-03-30 |
| EP2178858B1 (en) | 2011-12-28 |
| AU2008282032B2 (en) | 2014-08-07 |
| ES2380165T3 (es) | 2012-05-09 |
| EA201000283A1 (ru) | 2010-06-30 |
| CN101821256A (zh) | 2010-09-01 |
| AU2008282032A1 (en) | 2009-02-05 |
| NZ582934A (en) | 2011-10-28 |
| CA2694359A1 (en) | 2009-02-05 |
| RS52167B (en) | 2012-08-31 |
| US8518916B2 (en) | 2013-08-27 |
| ZA201001467B (en) | 2010-11-24 |
| IL203659A (en) | 2013-06-27 |
| PT2178858E (pt) | 2012-02-24 |
| PL2178858T3 (pl) | 2012-07-31 |
| EA018328B1 (ru) | 2013-07-30 |
| HRP20120225T1 (hr) | 2012-04-30 |
| US20090042841A1 (en) | 2009-02-12 |
| HK1141788A1 (en) | 2010-11-19 |
| BRPI0814182A2 (pt) | 2015-01-27 |
| CY1112500T1 (el) | 2015-12-09 |
| JP2010535165A (ja) | 2010-11-18 |
| WO2009015897A1 (en) | 2009-02-05 |
| EP2178858A1 (en) | 2010-04-28 |
| KR20100052507A (ko) | 2010-05-19 |
| JP5412430B2 (ja) | 2014-02-12 |
| ATE539075T1 (de) | 2012-01-15 |
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