CN101820923A - 对比剂 - Google Patents

对比剂 Download PDF

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Publication number
CN101820923A
CN101820923A CN200880111023A CN200880111023A CN101820923A CN 101820923 A CN101820923 A CN 101820923A CN 200880111023 A CN200880111023 A CN 200880111023A CN 200880111023 A CN200880111023 A CN 200880111023A CN 101820923 A CN101820923 A CN 101820923A
Authority
CN
China
Prior art keywords
dihydroxy
propyl group
iodo
methyl
hydroxyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN200880111023A
Other languages
English (en)
Chinese (zh)
Inventor
I·M·纽恩顿
D·G·温
V·莫里森-伊维森
J·M·帕斯摩尔
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
GE Healthcare AS
Original Assignee
GE Healthcare AS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by GE Healthcare AS filed Critical GE Healthcare AS
Publication of CN101820923A publication Critical patent/CN101820923A/zh
Pending legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/04—X-ray contrast preparations
    • A61K49/0433—X-ray contrast preparations containing an organic halogenated X-ray contrast-enhancing agent
    • A61K49/0438—Organic X-ray contrast-enhancing agent comprising an iodinated group or an iodine atom, e.g. iopamidol
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/28—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton
    • C07C237/46—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton having carbon atoms of carboxamide groups, amino groups and at least three atoms of bromine or iodine, bound to carbon atoms of the same non-condensed six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/56—Nitrogen atoms
    • C07D211/58—Nitrogen atoms attached in position 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/10—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by doubly bound oxygen or sulphur atoms
    • C07D295/104—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by doubly bound oxygen or sulphur atoms with the ring nitrogen atoms and the doubly bound oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/108—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by doubly bound oxygen or sulphur atoms with the ring nitrogen atoms and the doubly bound oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14—The ring being saturated

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Hydrogenated Pyridines (AREA)
CN200880111023A 2007-10-12 2008-10-10 对比剂 Pending CN101820923A (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
NO20075250 2007-10-12
NO20075250 2007-10-12
NO20076192 2007-11-30
NO20076192 2007-11-30
PCT/EP2008/063589 WO2009047319A1 (en) 2007-10-12 2008-10-10 Contrast agents

Publications (1)

Publication Number Publication Date
CN101820923A true CN101820923A (zh) 2010-09-01

Family

ID=40070938

Family Applications (1)

Application Number Title Priority Date Filing Date
CN200880111023A Pending CN101820923A (zh) 2007-10-12 2008-10-10 对比剂

Country Status (5)

Country Link
US (1) US8202511B2 (https=)
EP (1) EP2200656B1 (https=)
JP (1) JP2011500533A (https=)
CN (1) CN101820923A (https=)
WO (1) WO2009047319A1 (https=)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104109236A (zh) * 2014-07-21 2014-10-22 四川大学 含脂肪环半芳族聚芳醚酰胺及其制备方法
CN104356023A (zh) * 2014-10-29 2015-02-18 武汉工程大学 一种碘曲仑的制备方法
CN105017062A (zh) * 2014-04-18 2015-11-04 沈阳中海生物技术开发有限公司 制备碘普罗胺的新方法
CN110903275A (zh) * 2018-09-14 2020-03-24 苏州科伦药物研究有限公司 制备碘比醇的方法、其中间体及其制备方法

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8757270B2 (en) 2010-05-28 2014-06-24 Statoil Petroleum As Subsea hydrocarbon production system
CN104114190A (zh) * 2012-01-11 2014-10-22 通用电气医疗集团股份有限公司 具有低碘浓度的x-射线成像造影介质和x-射线成像方法
US20220242817A1 (en) * 2021-01-12 2022-08-04 Boston Scientific Scimed Inc. Iodinated compounds having radiocontrast properties
CN117623960B (zh) * 2023-12-27 2025-10-17 重庆圣华曦药业股份有限公司 一种碘美普尔中间体的制备方法

Family Cites Families (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE344166B (https=) 1966-12-13 1972-04-04 Pharmacia Ab
US3804892A (en) 1967-12-28 1974-04-16 Pharmacia Ab Novel 3,5-substituted 2,4,6-triiodobenzoic acids and salts thereof
SE315974B (https=) 1967-12-28 1969-10-13 Pharmacia Ab
US3763227A (en) 1967-12-28 1973-10-02 Pharmacia Ab Novel 3,5-substituted 2,4,6-triiodobenzoic acids and salts thereof
GB1488903A (en) 1974-05-31 1977-10-19 Guerbet Sa X-ray contrast media
GB1488904A (en) * 1975-05-22 1977-10-19 Guerbet Sa X-ray contrast media
GB1491129A (en) * 1975-06-04 1977-11-09 Guerbet Sa Iodo-benzene derivatives and an x-ray contrast medium containing them
DE2628517C2 (de) 1976-06-23 1985-02-21 Schering AG, 1000 Berlin und 4709 Bergkamen Dicarbonsäure-bis(3,5-dicarbamoyl-2,4,6-trijodanilid)-Verbindungen, Verfahren zu ihrer Herstellung und Röntgenkontrastmittel
CH626873A5 (https=) 1977-03-28 1981-12-15 Bracco Ind Chimica Spa
IT1207226B (it) 1979-08-09 1989-05-17 Bracco Ind Chimica Spa Derivati dell'acido 2,4,6-triiodo-isoftalico, metodo per la loro preparazione e mezzi di contrasto che li contengono.
DE3038853A1 (de) 1980-10-10 1982-05-27 Schering Ag, 1000 Berlin Und 4619 Bergkamen Neue n-hydroxy-alkylierte dicarbonsaeure-bis-(3,5-dicarbamoyl-2,4,6-trijodanilide), deren herstellung und diese enthaltende roentgenkonstrastmittel (ii)
DK160868C (da) 1982-11-08 1991-10-14 Nyegaard & Co As Trijodfenylderivater, fremgangsmaader til fremstilling deraf og radiologisk praeparat indeholdende dem
FR2634571B1 (fr) 1988-07-19 1990-10-19 Kodak Pathe Procede d'organisation et de lecture d'un support magnetique et support en faisant application
GB9020091D0 (en) 1990-09-14 1990-10-24 Nycomed As Contrast media
IT1245853B (it) 1990-11-16 1994-10-25 Bracco Spa 1,3-bis(3-(mono o poliidrossi)acilamino-5-(mono o poliidrossi-alchil) aminocarbonil-2,4,6-triiodo-benzoil-amino)-idrossi- o idrossi-alchil- propani, loro metodo di preparazione e mezzi di contrasto roentgenografici che li contengono
DE4109169A1 (de) * 1991-03-20 1992-09-24 Koehler Chemie Dr Franz Wasserloesliche nicht ionische roentgenkontrastmittel sowie mittel und verfahren zu ihrer herstellung
IT1256248B (it) * 1992-12-24 1995-11-29 Bracco Spa Formulazioni iniettabili acquose per radiodiagnostica comprendenti miscele di composti aromatici iodurati utili come agenti opacizzanti ai raggi x
GB9303992D0 (en) 1993-02-26 1993-04-14 Nycomed Imaging As Contrast agents
IT1264690B1 (it) * 1993-07-08 1996-10-04 Bracco Spa Compositi oligomeri iodurati e composizioni diagnostiche contenenti gli stessi
FR2717799B1 (fr) 1994-03-22 1996-07-19 Guerbet Sa Composés polyiodes : procédé de préparation ; composition de diagnostic.
AU6114396A (en) 1995-06-16 1997-01-15 Biophysica Foundation Formyl derivatives as nonionic contrast media
US6072069A (en) 1998-11-04 2000-06-06 Biophysica, Inc. Biodegradable nonionic contrast media
EP1186305A1 (en) 2000-09-07 2002-03-13 Schering Aktiengesellschaft New brominated compounds as contrast media for X-ray mammography
EP1492776B1 (en) 2002-03-27 2008-10-29 FUJIFILM Corporation Iodinated triglyceride analogs
WO2007133090A1 (en) * 2006-05-11 2007-11-22 Ge Healthcare As Contrast agents

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105017062A (zh) * 2014-04-18 2015-11-04 沈阳中海生物技术开发有限公司 制备碘普罗胺的新方法
CN105017062B (zh) * 2014-04-18 2018-11-20 沈阳中海生物技术开发有限公司 制备碘普罗胺的新方法
CN104109236A (zh) * 2014-07-21 2014-10-22 四川大学 含脂肪环半芳族聚芳醚酰胺及其制备方法
CN104109236B (zh) * 2014-07-21 2016-04-06 四川大学 含脂肪环半芳族聚芳醚酰胺及其制备方法
CN104356023A (zh) * 2014-10-29 2015-02-18 武汉工程大学 一种碘曲仑的制备方法
CN104356023B (zh) * 2014-10-29 2016-04-13 武汉工程大学 一种碘曲仑的制备方法
CN110903275A (zh) * 2018-09-14 2020-03-24 苏州科伦药物研究有限公司 制备碘比醇的方法、其中间体及其制备方法

Also Published As

Publication number Publication date
EP2200656A1 (en) 2010-06-30
US8202511B2 (en) 2012-06-19
EP2200656B1 (en) 2012-12-05
WO2009047319A1 (en) 2009-04-16
JP2011500533A (ja) 2011-01-06
US20100221189A1 (en) 2010-09-02

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C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
C02 Deemed withdrawal of patent application after publication (patent law 2001)
WD01 Invention patent application deemed withdrawn after publication

Application publication date: 20100901