CN101809032A - 用于选择性修饰蛋白质的方法 - Google Patents

用于选择性修饰蛋白质的方法 Download PDF

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Publication number
CN101809032A
CN101809032A CN200880108349A CN200880108349A CN101809032A CN 101809032 A CN101809032 A CN 101809032A CN 200880108349 A CN200880108349 A CN 200880108349A CN 200880108349 A CN200880108349 A CN 200880108349A CN 101809032 A CN101809032 A CN 101809032A
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CN
China
Prior art keywords
protein
glp
amino
insulin human
acid
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Withdrawn
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CN200880108349A
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English (en)
Chinese (zh)
Inventor
J·布查特
N·兰格兰约翰森
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Novo Nordisk Health Care AG
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Novo Nordisk AS
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Publication of CN101809032A publication Critical patent/CN101809032A/zh
Withdrawn legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0819—Tripeptides with the first amino acid being acidic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/61—Growth hormone [GH], i.e. somatotropin

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Endocrinology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CN200880108349A 2007-08-24 2008-08-25 用于选择性修饰蛋白质的方法 Withdrawn CN101809032A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US95773207P 2007-08-24 2007-08-24
US60/957732 2007-08-24
PCT/EP2008/061082 WO2009027369A1 (en) 2007-08-24 2008-08-25 Method for selectively modifying a protein

Publications (1)

Publication Number Publication Date
CN101809032A true CN101809032A (zh) 2010-08-18

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ID=39791006

Family Applications (1)

Application Number Title Priority Date Filing Date
CN200880108349A Withdrawn CN101809032A (zh) 2007-08-24 2008-08-25 用于选择性修饰蛋白质的方法

Country Status (5)

Country Link
US (1) US8586532B2 (enExample)
EP (1) EP2183279A1 (enExample)
JP (1) JP5703020B2 (enExample)
CN (1) CN101809032A (enExample)
WO (1) WO2009027369A1 (enExample)

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102939110A (zh) * 2010-04-21 2013-02-20 诺沃—诺迪斯克有限公司 蛋白质的选择性修饰
CN105593238A (zh) * 2013-07-11 2016-05-18 诺华股份有限公司 使用微生物转谷氨酰胺酶进行赖氨酸特异性化学酶法蛋白质修饰
CN107257802A (zh) * 2014-12-19 2017-10-17 豪夫迈·罗氏有限公司 转谷氨酰胺酶底物的鉴别及其用途
CN108129546A (zh) * 2018-01-11 2018-06-08 浙江理工大学 针对色氨酸及其残基的高选择性化学修饰方法
US12005079B2 (en) 2015-09-11 2024-06-11 The Board Of Trustees Of The Leland Stanford Junior University Biologically relevant orthogonal cytokine/receptor pairs
TWI932489B (zh) 2018-03-09 2026-07-21 史丹佛大學董事會 生物相關之正交細胞激素／受體對

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3079722B1 (en) 2013-12-13 2021-03-24 Novo Nordisk Health Care AG Method for thioether conjugation of proteins
WO2017055582A1 (en) 2015-10-01 2017-04-06 Novo Nordisk A/S Protein conjugates
EP3419670A2 (en) 2016-02-26 2019-01-02 Regeneron Pharmaceuticals, Inc. Optimized transglutaminase site-specific antibody conjugation

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4179337A (en) 1973-07-20 1979-12-18 Davis Frank F Non-immunogenic polypeptides
US6620916B1 (en) 1996-09-26 2003-09-16 Ajinomoto Co., Inc. Modified physiologically active proteins and medicinal compositions containing the same
US20070105770A1 (en) * 2004-01-21 2007-05-10 Novo Nordisk A/S Transglutaminase mediated conjugation of peptides
EP2033662B1 (en) * 2004-01-21 2012-10-17 Novo Nordisk Health Care AG Transglutaminase mediated conjugation of peptides
US20100009917A1 (en) 2007-02-22 2010-01-14 Novo Nordisk Health Care Ag Modulating Enzymatic Processes by Addition of Diolcontaining Substances

Cited By (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102939110A (zh) * 2010-04-21 2013-02-20 诺沃—诺迪斯克有限公司 蛋白质的选择性修饰
CN105593238A (zh) * 2013-07-11 2016-05-18 诺华股份有限公司 使用微生物转谷氨酰胺酶进行赖氨酸特异性化学酶法蛋白质修饰
CN107257802A (zh) * 2014-12-19 2017-10-17 豪夫迈·罗氏有限公司 转谷氨酰胺酶底物的鉴别及其用途
CN107257802B (zh) * 2014-12-19 2021-11-23 豪夫迈·罗氏有限公司 转谷氨酰胺酶底物的鉴别及其用途
US12005079B2 (en) 2015-09-11 2024-06-11 The Board Of Trustees Of The Leland Stanford Junior University Biologically relevant orthogonal cytokine/receptor pairs
CN108129546A (zh) * 2018-01-11 2018-06-08 浙江理工大学 针对色氨酸及其残基的高选择性化学修饰方法
CN108129546B (zh) * 2018-01-11 2020-09-11 浙江理工大学 针对色氨酸及其残基的高选择性化学修饰方法
TWI932489B (zh) 2018-03-09 2026-07-21 史丹佛大學董事會 生物相關之正交細胞激素／受體對

Also Published As

Publication number Publication date
WO2009027369A1 (en) 2009-03-05
JP5703020B2 (ja) 2015-04-15
US8586532B2 (en) 2013-11-19
EP2183279A1 (en) 2010-05-12
US20110269182A1 (en) 2011-11-03
JP2010536923A (ja) 2010-12-02

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Legal Events

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C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
ASS Succession or assignment of patent right

Owner name: NOVO NORDISK HEALTH CARE AG

Free format text: FORMER OWNER: NOVO NORDISK A/S

Effective date: 20110818

C41 Transfer of patent application or patent right or utility model
TA01 Transfer of patent application right

Effective date of registration: 20110818

Address after: Zurich

Applicant after: Novo Nordisk Health Care AG

Address before: Denmark bagsvaerd

Applicant before: NOVO Nordisk A/S

C04 Withdrawal of patent application after publication (patent law 2001)
WW01 Invention patent application withdrawn after publication

Application publication date: 20100818