CN101801369B - 磷铂及其在治疗顺铂和卡铂耐药性癌中的用途 - Google Patents

磷铂及其在治疗顺铂和卡铂耐药性癌中的用途 Download PDF

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CN101801369B
CN101801369B CN2008801015774A CN200880101577A CN101801369B CN 101801369 B CN101801369 B CN 101801369B CN 2008801015774 A CN2008801015774 A CN 2008801015774A CN 200880101577 A CN200880101577 A CN 200880101577A CN 101801369 B CN101801369 B CN 101801369B
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platinum
substituted
cancer
complex
compositions
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CN101801369A (zh
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拉廷德拉·N·博斯
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Ohio University
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Ohio University
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/24—Heavy metals; Compounds thereof
    • A61K33/243—Platinum; Compounds thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F15/00—Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic Table
    • C07F15/0006—Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic Table compounds of the platinum group
    • C07F15/0086—Platinum compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/661—Phosphorus acids or esters thereof not having P—C bonds, e.g. fosfosal, dichlorvos, malathion or mevinphos
    • A61K31/6615—Compounds having two or more esterified phosphorus acid groups, e.g. inositol triphosphate, phytic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/662—Phosphorus acids or esters thereof having P—C bonds, e.g. foscarnet, trichlorfon
    • A61K31/663—Compounds having two or more phosphorus acid groups or esters thereof, e.g. clodronic acid, pamidronic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/665—Phosphorus compounds having oxygen as a ring hetero atom, e.g. fosfomycin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Inorganic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
CN2008801015774A 2007-08-06 2008-08-06 磷铂及其在治疗顺铂和卡铂耐药性癌中的用途 Active CN101801369B (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US95412607P 2007-08-06 2007-08-06
US60/954,126 2007-08-06
US97392607P 2007-09-20 2007-09-20
US60/973,926 2007-09-20
PCT/US2008/072398 WO2009021082A2 (en) 2007-08-06 2008-08-06 Phosphaplatins and their use in the treatment of cancers resistant to cisplantin and carboplatin

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CN101801369A CN101801369A (zh) 2010-08-11
CN101801369B true CN101801369B (zh) 2012-09-19

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CN2008801015774A Active CN101801369B (zh) 2007-08-06 2008-08-06 磷铂及其在治疗顺铂和卡铂耐药性癌中的用途

Country Status (12)

Country Link
US (4) US7700649B2 (https=)
EP (2) EP2668949A1 (https=)
JP (2) JP5385274B2 (https=)
CN (1) CN101801369B (https=)
CY (1) CY1115504T1 (https=)
DK (1) DK2173337T3 (https=)
ES (1) ES2495743T3 (https=)
HR (1) HRP20140808T1 (https=)
PL (1) PL2173337T3 (https=)
PT (1) PT2173337E (https=)
SI (1) SI2173337T1 (https=)
WO (2) WO2009021081A2 (https=)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2495743T3 (es) * 2007-08-06 2014-09-17 Ohio University Fosfaplatinos y su uso en el tratamiento de cánceres resistentes a cisplatino y carboplatino
CN108210516A (zh) * 2010-06-04 2018-06-29 俄亥俄大学 磷铂及其在治疗癌症中的用途
US20130236568A1 (en) 2011-01-12 2013-09-12 Ohio University Phosphaplatins having anti-angiogenic, anti-metastatic, and pro-apoptotic properties and uses thereof
EP2729526B1 (en) 2011-07-08 2017-10-04 Dow Global Technologies LLC Polyethylene blend composition suitable for blown film, method of producing the same, and films made therefrom
JP6027619B2 (ja) 2011-10-05 2016-11-16 ラシンドラ・エヌ・ボーズ ホスファプラチン系抗腫瘍剤の大規模調製のための効率的プロセス
WO2013052839A1 (en) 2011-10-05 2013-04-11 Bose Rathindra N Efficient processes for large scale preparation of phosphaplatins antitumor agents
MX365635B (es) 2011-10-20 2019-06-10 Nerium Biotechnology Inc Combinacion terapeutica para el tratamiento de cancer.
LT2855496T (lt) * 2012-05-24 2017-04-10 Phosplatin Therapeutics Llc Fosfaplatinos junginių sintezės ir gryninimo būdai ir jų panaudojimas
EP2958568B1 (en) * 2013-02-22 2020-03-04 University Of Houston Phosphaplatins as neuroprotective agents
WO2015127037A1 (en) * 2014-02-19 2015-08-27 University Of Houston System Compositions and methods for the treatment of neurodegenerative diseases
MX370673B (es) 2014-06-11 2019-12-19 Univ Texas Conjugados y composiciones de texafirina-pt (iv) para su uso para superar la resistencia del platino.
EP3397642A1 (en) 2015-12-30 2018-11-07 Atilim Universitesi Dna targeted mono and heterodinuclear complexes
TWI791008B (zh) 2017-01-06 2023-02-01 美商弗斯普萊汀治療股份有限公司 作為供骨癌或血癌治療用之治療劑的磷酸鉑(phosphaplatin)化合物
JP7381083B2 (ja) 2017-09-08 2023-11-15 フォスプラティン テラピューティクス インコーポレイテッド 免疫調節剤としてのホスファプラチン化合物およびその治療的使用

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4234500A (en) * 1979-03-07 1980-11-18 Engelhard Minerals & Chemicals Corporation Ethylenediamine platinum(II) and 1,2-diamino-cyclohexane platinum(II) pyrophosphate complexes
EP0409527A2 (en) * 1989-07-18 1991-01-23 Engelhard Corporation Cis-diamineplatinum complexes with methanediphosphonate and substituted methanediphosphonate ligands as antitumor agents
WO2005000858A2 (en) * 2003-06-27 2005-01-06 Akira Odani Bisphosphonate complexes

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4291027A (en) 1979-03-07 1981-09-22 Engelhard Minerals & Chemicals Corp. Method for treating tumors with ethylenediamine platinum (II) and 1,2-diaminocyclohexane-platinum (II) pyrophosphate complexes
EP2177525A1 (en) * 2007-07-06 2010-04-21 TMRC Co., Ltd. Metal complex compound, cancer therapeutic composition comprising the metal complex compound as active ingredient, and intermediate for production of the metal complex compound
ES2495743T3 (es) * 2007-08-06 2014-09-17 Ohio University Fosfaplatinos y su uso en el tratamiento de cánceres resistentes a cisplatino y carboplatino

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4234500A (en) * 1979-03-07 1980-11-18 Engelhard Minerals & Chemicals Corporation Ethylenediamine platinum(II) and 1,2-diamino-cyclohexane platinum(II) pyrophosphate complexes
EP0409527A2 (en) * 1989-07-18 1991-01-23 Engelhard Corporation Cis-diamineplatinum complexes with methanediphosphonate and substituted methanediphosphonate ligands as antitumor agents
WO2005000858A2 (en) * 2003-06-27 2005-01-06 Akira Odani Bisphosphonate complexes

Also Published As

Publication number Publication date
SI2173337T1 (sl) 2014-10-30
US8034964B2 (en) 2011-10-11
CY1115504T1 (el) 2017-01-04
US20110313182A1 (en) 2011-12-22
WO2009021082A3 (en) 2009-04-23
US20090042838A1 (en) 2009-02-12
JP5385274B2 (ja) 2014-01-08
WO2009021081A3 (en) 2009-05-07
PL2173337T3 (pl) 2014-11-28
ES2495743T3 (es) 2014-09-17
WO2009021081A2 (en) 2009-02-12
HRP20140808T1 (hr) 2014-10-24
US20130237503A1 (en) 2013-09-12
HK1143551A1 (en) 2011-01-07
WO2009021082A2 (en) 2009-02-12
EP2173337A4 (en) 2010-10-27
EP2173337A2 (en) 2010-04-14
US20100233293A1 (en) 2010-09-16
JP2010535803A (ja) 2010-11-25
US7700649B2 (en) 2010-04-20
EP2668949A1 (en) 2013-12-04
EP2173337B1 (en) 2014-07-30
CN101801369A (zh) 2010-08-11
US8653132B2 (en) 2014-02-18
JP5647300B2 (ja) 2014-12-24
JP2013227218A (ja) 2013-11-07
US8445710B2 (en) 2013-05-21
PT2173337E (pt) 2014-09-03
DK2173337T3 (da) 2014-09-15

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