CN101785535B - Feed additive containing chicken alpha interferon - Google Patents
Feed additive containing chicken alpha interferon Download PDFInfo
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- CN101785535B CN101785535B CN2010101448515A CN201010144851A CN101785535B CN 101785535 B CN101785535 B CN 101785535B CN 2010101448515 A CN2010101448515 A CN 2010101448515A CN 201010144851 A CN201010144851 A CN 201010144851A CN 101785535 B CN101785535 B CN 101785535B
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- feed
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Abstract
The invention discloses a feed additive containing chicken alpha interferon, which is prepared by mixing zymophyte, pine needle powder, black soil powder, vitamin B1, vitamin B2, vitamin E, folic acid powder, ginseng fibrous root powder, ginkgo leaf and chicken alpha interferon powder. The additive of the invention has the broad-spectrum anti-viral function, has strong anti-viral function and can serve as precautionary measures for a long term; and the feed additive can perform the function in vivo if being eaten by livestocks in the mode of being mixed in the feed, and the feed additive induces and resists bacteria in vivo, performs the early-term precaution action and can be used for long-term precaution and early-term treatment to various viral diseases including bird flu. The additive of the invention has strong immunoregulation action and can strengthen livestock immunity, eliminate pesticide and hormone residue, add nutrient substances and improve the taste of meat, eggs and milk.
Description
Technical field
The present invention relates to a kind of feed addictive that is used for animal and fowl fodder, a kind of specifically additive for farm animal feed that contains chicken alpha interferon.
Background technology
Along with growth in the living standard, human increasing to the demand of food such as meat, egg, milk, also increasingly high to quality and nutritional requirement.
In order to satisfy the human animal products demand that enlarges day by day, the breeding way of livestock and poultry breeding industry from traditional extensive operation to high density, intensive culture high speed development.New breeding way is pursued delivering for sale or the speed of laying eggs of livestock and poultry owing to too pay attention to output, generally uses the feed that is added with various additives or even hormone to feed livestock and poultry.And this breeding way makes the animal products quality descend inevitably, and meat, egg, milk nutritional labeling disappearance, even cause harmful substance such as hormone residual have influenced human healthy.
Simultaneously, be accompanied by high speed development expensive, intensive culture, the disease problem has inevitably formed maximum threat to the livestock and poultry industry, has caused serious economy loss to aquaculture, becomes the fast-developing big bottleneck of restriction livestock and poultry industry.
What breed endangered maximum to fowl poultry kind is infectious disease, and especially virosis accounts for 70% of disease total amount.Still lack the efficacious therapy means for the fowl poultry kind viral disease at present, the prevention and the treatment approach of fowl poultry kind infectious disease is mainly vaccine and antibiotic.But, be prone to cause drug resistance after most of antibiotics and the prolonged and repeated use of traditional oral chemicals, and cause the medicament residue in the animal body easily, bring negative effect to health.And traditional vaccine is because its high specific, can't keep out the new impact that the appearance of variation and the novel disease of virus brings to livestock and poultry breeding industry.
Chicken alpha interferon is one type of glycoprotein that extensive BA is arranged, and full gene is 582 bases, 193 amino acid of encoding, and wherein 31 amino acid are signal peptide, and back 162 amino acid are maturation protein, and molecular weight of albumen is about 19KD.Chicken alpha interferon has multiple functions such as regulating body's immunity, antiviral, antitumor, antiproliferative.Use chicken alpha interferon can reach antiviral effect through the adjusting to body immune system, do not have drug resistance and medicament residue risk, and have the antiviral activity of wide spectrum, therefore having received widely, the parent looks at.
Summary of the invention
The purpose of this invention is to provide a kind of feed addictive that contains chicken alpha interferon, to strengthen immunity of livestock, the nutrition that improves meat, egg, milk.
The feed addictive that the present invention contains chicken alpha interferon is by zymophyte, pine needle meal, black earth powder, Cobastab
1, Cobastab
2, vitamin E, folic acid powder, ginseng fibrous root's powder, ginkgo leaf powder and chicken alpha interferon powder be that component is mixed and is made into, the weight ratio of the branch of its each component is:
Zymophyte 5～10 pine needle meals 45～70
Black earth powder 5～20 Cobastabs
10.01～0.07
Cobastab
20.01～0.07 vitamin E 0.01～0.07
Folic acid powder 0.01～0.07 ginseng fibrous root's powder 5～15
Ginkgo leaf powder 5～15 chicken alpha interferon powder 0.6～1.2.
The present invention contains the further components by weight of feed addictive of chicken alpha interferon:
Zymophyte 6～8 pine needle meals 50～65
Black earth powder 6～18 Cobastabs
10.02～0.06
Cobastab
20.02～0.06 vitamin E 0.02～0.06
Folic acid powder 0.02～0.06 ginseng fibrous root's powder 8～12
Ginkgo leaf powder 6～12 chicken alpha interferon powder 0.8～1.0.
Wherein, contain brood cell bacterium, saccharomycete and lactic acid bacteria in the described zymophyte, its content separately is: brood cell bacterium 0.1～0.6 hundred million/gram, saccharomycete 0.01～0.06 hundred million/gram, lactic acid bacteria 0.01～0.06 hundred million/gram.
The feed addictive that the present invention contains chicken alpha interferon directly adds in the feed and uses, and its addition suitable in feed is to add 0.6～1.2 jin of additive in the per kilogram feed.
Additive of the present invention has the broad-spectrum disease resistance toxic action; And antivirus action is strong; Can be used as long-term precautionary measures, livestock and poultry only need can get in the body with the feed feed and play a role, in vivo the inducing anti-disease poison; Performance early prevention effect can be used for comprising the long-term control and the early treatment of the various viral diseases of bird flu.
Additive of the present invention also has powerful immunoregulation effect, can strengthen immunity of livestock, eliminates agricultural chemicals, hormone residues, the material that has additional nutrients, the taste of raising meat, egg, milk.Additive of the present invention is easy to use, and is simple, and environmental protection.
The specific embodiment
Below in conjunction with embodiment the present invention is further described, but said embodiment is not as to qualification of the present invention.
Embodiment 1
Contain in per 100 gram feed addictives: zymophyte 7 grams, pine needle meal 57 grams, black earth powder 18 grams, Cobastab
10.05 gram, Cobastab
20.05 gram, vitamin E 0.05 gram, folic acid powder 0.05 gram, ginseng fibrous root's powder 8 grams, ginkgo leaf powder 9 grams, chicken alpha interferon powder 0.8 gram.
Wherein, contain 0.3 hundred million of brood cell bacteriums/gram in the zymophyte, 0.05 hundred million/gram of saccharomycete, 0.05 hundred million/gram of lactic acid bacteria.
Above material is pulverized in pulverizer, evenly mixed, promptly process feed addictive according to said weight.
Embodiment 2
Contain in per 100 gram feed addictives: zymophyte 6 grams, pine needle meal 58 grams, black earth powder 17 grams, Cobastab
10.05 gram, Cobastab
20.05 gram, vitamin E 0.05 gram, folic acid powder 0.05 gram, ginseng fibrous root's powder 9 grams, ginkgo leaf powder 9 grams, chicken alpha interferon powder 0.8 gram.
Wherein, contain 0.3 hundred million of brood cell bacteriums/gram in the zymophyte, 0.05 hundred million/gram of saccharomycete, 0.05 hundred million/gram of lactic acid bacteria.
Above material is pulverized in pulverizer, evenly mixed, promptly process feed addictive according to said weight.
Embodiment 3
Contain in per 100 gram feed addictives: zymophyte 8 grams, pine needle meal 56 grams, black earth powder 17 grams, Cobastab
10.02 gram, Cobastab
20.02 gram, vitamin E 0.04 gram, folic acid powder 0.04 gram, ginseng fibrous root's powder 8 grams, ginkgo leaf powder 10 grams, chicken alpha interferon powder 0.9 gram.
Wherein, contain 0.3 hundred million of brood cell bacteriums/gram in the zymophyte, 0.05 hundred million/gram of saccharomycete, 0.05 hundred million/gram of lactic acid bacteria.
Above material is pulverized in pulverizer, evenly mixed, promptly process feed addictive according to said weight.
Embodiment 4
Contain in per 100 gram feed addictives: zymophyte 6 grams, pine needle meal 60 grams, black earth powder 15 grams, Cobastab
10.02 gram, Cobastab
20.02 gram, vitamin E 0.04 gram, folic acid powder 0.04 gram, ginseng fibrous root's powder 12 grams, ginkgo leaf powder 6 grams, chicken alpha interferon powder 0.9 gram.
Wherein, contain 0.3 hundred million of brood cell bacteriums/gram in the zymophyte, 0.05 hundred million/gram of saccharomycete, 0.05 hundred million/gram of lactic acid bacteria.
Above material is pulverized in pulverizer, evenly mixed, promptly process feed addictive according to said weight.
Application examples 1
Feed addictive is to the influence of laying hen premunition, production performance and the quality of laying eggs
In the laying hens essential ration as shown in table 1 of filling a prescription, add the feed addictive (representing) that the embodiment of the invention 1 provides, observe of the influence of the additive of various dose laying hen premunition, production performance and the quality of laying eggs with IF1.
The feed formula of table 1 basal diet and trophic level
Get 1000 Hainan ashes and test laying hens (60 ages in week, laying hen later stage), be divided into 4 groups (the blank group and the IF1 5mg/kg group of adding, interpolation IF1 8mg/kg group, interpolation IF1 10mg/kg group) at random, every group of 5 repetitions, each repeats 50 chickens.In 4 weeks of experimental period, contrast indexs such as laying rate, egg size and the yolk colourity of each group, shell thickness, dense albumen height, anti-newcastle epidemic disease antibody are listed in table 2.
Production performance between table 2 test group and control group and egg product matter are relatively
| Divide into groups | 1 | 2 | 3 | 4 |
| Performance indications | Blank 0mg/kg | Add IF1 5mg/kg | Add IF1 8mg/kg | Add IF1 10mg/kg |
| Egg size (g) | 60.12 | 62.31 | 63.21 | 64.23 |
| Dense albumen height | 5.54 | 5.77 | 5.59 | 5.97 |
| Yolk colourity | 5.53 | 7.42 | 7.65 | 8.02 |
| Eggshell strength | 3.21 | 3.58 | 3.65 | 3.74 |
| Shell thickness | 365.11 | 375.21 | 379.12 | 380.13 |
| Laying rate | 82.1 | 85.3 | 86.1 | 86.5 |
| Feedstuff-egg ratio | 2.51 | 2.23 | 2.21 | 2.25 |
| Anti-newcastle epidemic disease antibody | 0.75 | 1.13 | 1.21 | 1.31 |
Listed result can find out from table 2; The test laying hen each item index that is added with additive product of feeding all obviously is better than the test laying hen of the common mixed feed of feeding; Particularly the antibody horizontal of yolk colourity and newcastle disease vaccine is significantly higher than control group, explains that feed addictive provided by the invention is all having tangible good action aspect the antibody horizontal of the production performance that improves laying hen and egg product matter and raising laying hen and the premunition.
Application examples 2
Feed addictive is grown the influence on (premunition) to fryer in production performance and immune system
In the meat chick feeding feed stuff in different ages in week, add the feed addictive (representing) that the embodiment 2 of various dose provides with IF2, detect behind the feeding feed stuff additive to immune organ grow, the influence of indexs such as antibody horizontal (premunition) and production performance.
Test daily ration prescription that the meat chick in different ages in week is fed and the trophic level that reaches be page table 3 as follows, and result of the test is listed in down page table 4.
Can find out from table 4; The feed that is added with feed addictive of feeding can significantly improve the speed of growth of meat chick and the utilization rate of feed; And can significantly promote the growth of thymus gland, spleen and the bursa of farbricius; Improving its relative weight is the immune organ index, and the growth that feed addictive provided by the invention can the immune stimulatory organ is described.And immune organ is the vitals and the material base of immunity of performance immunocyte and humoral immunity, and the increase of immune organ weight can explain that feed addictive provided by the invention can improve the premunition of animal.In sum, feed addictive provided by the invention promotes that growth of meat chicken is two the very important indexs of feed addictive of the present invention as the antibiotic substitute with improving premunition.
Table 3 meat chick daily ration prescription and the trophic level that reaches
Annotate: per kilogram daily ration cupric 12mg, iodine 0.45mg, iron 112mg, manganese 111mg, selenium 0.23mg, zinc 121mg, cobalt 0.42mg, V
A8800IU, V
D33050IU, V
E22.3IU, V
K31.8mg, biotin 0.3mg, folic acid 1.2mg, niacin 51mg, pantothenic acid 11mg, riboflavin 6.8mg, thiamine 3.3mg adjoins the pure 4.5mg that trembles, V
B120.03mg, choline 1305mg.
The influence of table 4 meat chick production performance in pairs 6 age in week and immune organ developmental level
| Divide into groups | The IF2 addition | Body weight (g) | Material anharmonic ratio (F/G) | Thymus gland (g/kg body weight) | Spleen (g/kg body weight) | The bursa of farbricius heavy (g/kg body weight) |
| 1 | Blank 0mg/kg | 1301.2 | 2.29 | 1.66 | 1.97 | 2.18 |
| 2 | Add IF2 10mg/kg | 1419.1 | 2.13 | 1.98 | 2.68 | 2.66 |
| 3 | Add IF2 8mg/kg | 1416.2 | 2.16 | 1.96 | 2.51 | 2.61 |
| 4 | Add IF2 5mg/kg | 1409.1 | 2.19 | 1.91 | 2.43 | 2.59 |
Claims (2)
1. feed addictive that contains chicken alpha interferon; Be to be that component is mixed and to be made into by zymophyte, pine needle meal, black earth powder, vitamin B1, vitamin B2, vitamin E, folic acid powder, ginseng fibrous root's powder, ginkgo leaf powder and chicken alpha interferon powder, the weight ratio of its each component is:
Wherein, contain brood cell bacterium, saccharomycete and lactic acid bacteria in the described zymophyte, its content separately is: brood cell bacterium 0.1～0.6 hundred million/gram, saccharomycete 0.01～0.06 hundred million/gram, lactic acid bacteria 0.01～0.06 hundred million/gram.
2. the feed addictive that contains chicken alpha interferon according to claim 1 is characterized in that the weight ratio of each component is:
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2010101448515A CN101785535B (en) | 2010-04-08 | 2010-04-08 | Feed additive containing chicken alpha interferon |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2010101448515A CN101785535B (en) | 2010-04-08 | 2010-04-08 | Feed additive containing chicken alpha interferon |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN101785535A CN101785535A (en) | 2010-07-28 |
| CN101785535B true CN101785535B (en) | 2012-10-31 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN2010101448515A Expired - Fee Related CN101785535B (en) | 2010-04-08 | 2010-04-08 | Feed additive containing chicken alpha interferon |
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Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2355527A1 (en) * | 2000-08-21 | 2002-02-21 | Nisshin Feed Inc. | Animal feed additives |
| CN101002591A (en) * | 2006-01-16 | 2007-07-25 | 邵峰 | Feed additive and feed |
| CN101176510A (en) * | 2007-10-16 | 2008-05-14 | 辽宁省农业科学院草牧业研究所 | Hen green complex feed additive and preparation method thereof |
| CN101297679A (en) * | 2007-08-07 | 2008-11-05 | 天津生机集团有限公司 | Feedstuff additive for improving immunity of livestock and poultry and preparation thereof |
| CN101417122A (en) * | 2008-12-04 | 2009-04-29 | 山东华辰生物科技有限公司 | Recombination chicken alpha-interferon injection and preparation method thereof |
| CN101579042A (en) * | 2009-06-22 | 2009-11-18 | 西北农林科技大学 | Laying hen feed additive |
-
2010
- 2010-04-08 CN CN2010101448515A patent/CN101785535B/en not_active Expired - Fee Related
Patent Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2355527A1 (en) * | 2000-08-21 | 2002-02-21 | Nisshin Feed Inc. | Animal feed additives |
| CN101002591A (en) * | 2006-01-16 | 2007-07-25 | 邵峰 | Feed additive and feed |
| CN101297679A (en) * | 2007-08-07 | 2008-11-05 | 天津生机集团有限公司 | Feedstuff additive for improving immunity of livestock and poultry and preparation thereof |
| CN101176510A (en) * | 2007-10-16 | 2008-05-14 | 辽宁省农业科学院草牧业研究所 | Hen green complex feed additive and preparation method thereof |
| CN101417122A (en) * | 2008-12-04 | 2009-04-29 | 山东华辰生物科技有限公司 | Recombination chicken alpha-interferon injection and preparation method thereof |
| CN101579042A (en) * | 2009-06-22 | 2009-11-18 | 西北农林科技大学 | Laying hen feed additive |
Non-Patent Citations (1)
| Title |
|---|
| 韦琴等.鸡α干扰素基因的克隆、原核表达及抗病毒效果研究.《生物工程学报》.2006,第22卷(第5期),737-743. * |
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| CN101785535A (en) | 2010-07-28 |
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