CN101780246A - Traditional Chinese medicine composition with function of promoting digestion and preparation method thereof - Google Patents
Traditional Chinese medicine composition with function of promoting digestion and preparation method thereof Download PDFInfo
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Abstract
The invention discloses a traditional Chinese medicine composition with function of promoting digestion and a preparation method thereof. The composition is prepared by parched hawthorn, dried orange peel and amomum fruit in certain weight ratio. The composition has the function of promoting digestion.
Description
Technical field
The present invention relates to a kind of Chinese medicine composition and preparation method thereof, belong to Chinese medicine and field of health care food with facilitating digestion function.
Background technology
Dyspepsia is a kind of by the caused disease of gastric motility disorder, also comprises gastroparesis and esophageal regurgitation disease that gastric peristalsis is bad, in fact is exactly the general name of all stomach discomfort.Symptom shows as epigastric discomfort or pain by spells, glutted, heartburn (acid regurgitation), belch etc.
Cause that dyspeptic reason is a lot, comprise the chronic inflammatory disease at harmonization of the stomach duodenum position, make esophagus, stomach, duodenal normal creepage of gastrointestinal functions functional disorder.Dyspepsia can be accidental, also can be chronic lasting.Accidental dyspepsia can be by feed satiety, insobriety, often take analgesic such as aspirin etc. causes.When psychentonia, take food, or the unused diet of taking food also can cause.The dyspepsia of chronic persistence can be neuropathic, be that Nervous and Mental Factors causes, also can be that wasting diseasess such as some organic disease such as chronic gastritis, gastric and duodenal ulcers, chronic hepatitis cause, dyspepsia also can often take place in the patient after gallbladder is extractd.No matter which kind of reason all is because stomach lacks power, can not normally carries out work, and make food at the gastric overstand.
The traditional Chinese medical science thinks that dyspepsia is many because of weakness of the spleen and stomach, or eating and drinking without temperance, the thing of surfeit melon and fruit raw food; Or improper feeding, nutrient malabsorption; Or because of being invaded by exogenous pathogen, impairing the spleen and stomach, so that transformation failure of spleen and cause primary disease.In the treatment, should be according to the cause of disease and symptom performance, dialectical executing controlled, and be aid digestion based on invigorating spleen and reinforcing stomach.
Summary of the invention
The object of the invention just provides a kind of Chinese medicine composition with facilitating digestion function.
Another object of the present invention has provided the preparation method of this Chinese medicine composition.
The present invention is achieved by the following technical solutions:
The present invention is made by the following weight proportion raw material:
Fructus Crataegi (parched to brown) 9-12g, Pericarpium Citri Reticulatae 3-9g, Fructus Amomi 3-6g
Be preferably:
Fructus Crataegi (parched to brown) 12g, Pericarpium Citri Reticulatae 6g, Fructus Amomi 4g
The preparation method of Chinese medicine composition of the present invention is as follows:
With Fructus Crataegi (parched to brown), Pericarpium Citri Reticulatae, Fructus Amomi, adding ethanol extracts, extracting solution is concentrated, dry, make dry extract, be ground into powder, add various conventional adjuvant required when preparing different dosage form, as diluent, disintegrating agent, excipient, binding agent, lubricant, surfactant, filler, antiseptic, stabilizing agent, correctives, thickening agent, fluidizer etc., method of Chinese medicinal with routine is prepared into any peroral dosage form commonly used, as tablet, dispersible tablet, effervescent tablet, oral cavity disintegration tablet, buccal tablet, chewable tablet, capsule, microcapsule, granule, pill, powder, drop pill, slow releasing preparation, controlled release preparation etc.
The preferred for preparation method of Chinese medicine composition of the present invention is as follows:
With Fructus Crataegi (parched to brown), Pericarpium Citri Reticulatae, Fructus Amomi, add twice of 6 times of amount 70% ethanol extraction, filter, merging filtrate, reclaim ethanol, be evaporated to relative density and measure 1.25-1.30 down for 60 ℃, drying under reduced pressure, make dry extract, be ground into fine powder, add various conventional adjuvant required when preparing different dosage form, as diluent, disintegrating agent, excipient, binding agent, lubricant, surfactant, filler, antiseptic, stabilizing agent, correctives, thickening agent, fluidizer etc., method of Chinese medicinal with routine is prepared into any peroral dosage form commonly used, as tablet, dispersible tablet, effervescent tablet, oral cavity disintegration tablet, buccal tablet, chewable tablet, capsule, microcapsule, granule, pill, powder, drop pill, slow releasing preparation, controlled release preparation etc.
Each drug mechanism is as follows among the present invention:
Fructus Crataegi (parched to brown): the acid of Fructus Crataegi sweet in the mouth, slightly warm in nature go into spleen, stomach, liver three warps, but promoting digestion and removing stagnation, blood circulation promoting and blood stasis dispelling, anthelmintic cure mainly meat stagnation, distension and fullness in the abdomen, the painful diarrhea of abdomen, the lower abdominal pain that postnatal blood stasis causes, diseases such as hernia swelling and hanging down of either of the testes distending pain.Fructus Crataegi has important medical value, since ancient times, just becomes the good medicine of spleen benefiting and stimulating the appetite, relieving dyspepsia, phlegm reduction of blood circulation promoting.Fructus Crataegi contains materials such as saccharide, protein, fat, vitamin C, carotene, starch, malic acid, citric acid, calcium and ferrum.It is not only sour-sweet delicious, the secretion of energy facilitating digestion liquid, and appetite stimulator, facilitating digestion also has multiple medical value.Most important effect is good for the stomach exactly, removing food stagnancy, famous JIAOSANXIAN (Fructus Crataegi, Fructus Hordei Germinatus, Massa Medicata Fermentata) in the Chinese medicine, be aid digestion, control diarrheal prescription commonly used, Fructus Crataegi promptly is " celestial being " wherein.
Pericarpium Citri Reticulatae: Pericarpium Citri Reticulatae acrid in the mouth, property hardship, temperature, go into spleen, lung meridian; The merit that appetizing, drying dampness to eliminate phlegm are arranged in circulation of qi promoting spleen invigorating, stopping nausea and vomiting by lowering the adverse flow of QI, the accent is applicable to distension and fullness in the abdomen, belch due to the stagnation of QI in spleen and stomach, feels sick, the diseases such as cough with copious phlegm of the thin and phlegm dampness obstruction pattern in indigestion and loss of appetite asthenia, big loose stool due to vomiting and the retention of dampness in middle-JIAO.The contained volatile oil of Pericarpium Citri Reticulatae has gentle stimulation to gastrointestinal tract, but pneumatosis in the intestinal tube is got rid of in the secretion of facilitating digestion liquid, has shown that its fragrance is good for the stomach and the effect of the wind dispelling therapeutic method to keep the adverse QI flowing downwards.
Fructus Amomi: Fructus Amomi acrid in the mouth, warm in nature, go into liver, stomach warp, tool removing dampness appetizing, warming spleen and stopping diarrha, the antiabortive effect of regulating the flow of vital energy.Be used for turbid damp obstructing in middle-JIAO, the gastral cavity painful abdominal mass is not hungry, Deficiency and coldness of spleen and stomach, and vomiting is had loose bowels, pregnancy reactions, diseases such as frequent fetal movement.Its appetite stimulator that can whet the appetite is applicable to stagnation of QI in spleen and stomach, and appetite is not opened, and dyspeptic vomiting is had loose bowels.
Because contained tannic acid combines with gastric acid and forms gastrolith easily in the Fructus Crataegi, and is nondigestible.If not falling, the long-time digestion of gastrolith will not cause gastric ulcer, gastrorrhagia even gastric perforation.So select for use Fructus Crataegi (parched to brown) to relax its acidity in the side, reduce tannic acid content, therefore also be applicable to the people that gastrointestinal function is weak.
Fructus Crataegi (parched to brown) is good for the stomach, helps digestion among the present invention, Pericarpium Citri Reticulatae circulation of qi promoting, appetizing, and Fructus Amomi removing dampness appetizing, three flavors cooperate all the effect that is good for the stomach.
In sum, the present composition has the effect of facilitating digestion.Can be used for preparation dyspeptic medicine of treatment and health product.
Further set forth the beneficial effect of Chinese medicine composition of the present invention by following experiment.
Chinese medicine composition of the present invention has the effect that promotes mice digestion:
Test material:
Trial drug: the present composition, crowd's recommended intake is 1.5g/30kg (0.05g/kg), it is crushed to Powdered, the given the test agent powder that takes by weighing corresponding weight in the experiment respectively is dissolved in and is made into certain density sample in the distilled water, irritates stomach for each dosage group and uses.
Experimental animal: 40 of SPF level Wistar female rats, body weight 120g～150g.
Adopt SPF level Wistar rat to carry out the determination test of digestive enzyme, every group 10, negative control group is set and is tried the basic, normal, high dosage group of thing and (be respectively 5,10,20 times of crowd's recommended amounts, be 0.25g/kg, 0.5g/kg, 1.0g/kg), being tried thing continuous irrigation stomach, to give the time be 30 days, negative control group gives distilled water and irritates stomach, and the filling stomach of rat is 0.1ml/10g.
The sample preparation: the mensuration of digestive enzyme: compound concentration is 0.025g/ml, 0.050g/ml, 0.100g/ml.
Experimental technique and observation index:
Digestive enzyme is measured: in this experiment 40 rats are divided at random negative control group and basic, normal, high dosage group, 10 every group.Each dosage treated animal continuous irrigation stomach was tried thing 30 days, and negative control group gives the equivalent distilled water simultaneously.After each treated animal fasting 24 hours before being tried (during freely drink water), use the etherization rat, by 5 hours gastric juice of pyloric ligation collection output, gastric juice output analytical unit time, pepsin activity, calculating pepsin output; Determination of peptic activity adopts the MettShi method, promptly selecting internal diameter for use is the 1.5mm glass tubing, inject fresh Ovum Gallus domesticus album, put to keep flat in the hot bath and take out after making protein coagulating, discard alveolate protein pipe, putting refrigerator preserves, face with before making 3cm length, select 100ml band plug ground triangular flask simultaneously for use, add 0.05mol/L hydrochloric acid 15ml by gastric juice output 1ml and put mixing in the triangular flask, every bottle adds 2 of 3cm length protein pipe, sealing is put in the calorstat and is taken out after 24 hours, with the length (mm) of vernier caliper measurement protein pipe two ends transparent part, value with four ends is averaged, pepsin activity unit (U)=meansigma methods
2* 16, and utilize formula pepsin output (U/hr)=pepsin activity * gastric juice amount hourly, calculate pepsic output.
Statistical method: result of the test is set up the data base with Excel, and statistical analysis software is SPSS, adopts variance analysis and nonparametric statistical method to calculate and check.
Table 1: rat stomach liquid measure measurement result (x ± s)
Compare p＞0.05 with negative control group.
Table 2: rat stomach proteinase activity and protease output measurement result (x ± s)
Compare with negative control group
*P＜0.05;
*P＜0.01.
This experimental result shows, with negative control group relatively, each dosage group gastric juice output difference does not have significance, high dose group can obviously increase pepsin activity, difference has significance, and per hour the pepsin output obviously increase, difference has significance.According to above experimental result, can judge that this is tried thing and has the facilitating digestion function.
The specific embodiment
Embodiment 1:
The preparation of the tablet of Chinese medicine composition of the present invention
A) take by weighing Fructus Crataegi (parched to brown) 12kg, Pericarpium Citri Reticulatae 6kg, Fructus Amomi 4kg, standby;
B), add 6 times of amount 70% ethanol extractions twice, merging filtrate with Fructus Crataegi (parched to brown), Pericarpium Citri Reticulatae, Fructus Amomi;
C) filtrate recycling ethanol is evaporated to relative density and measures 1.25-1.30 down for 60 ℃, and drying under reduced pressure makes dry extract;
D) pulverize, cross 80 mesh sieves;
E) system granule, drying, compacting is in blocks, and coating promptly gets tablet
Embodiment 2:
The preparation of the dispersible tablet of Chinese medicine composition of the present invention
A) take by weighing Fructus Crataegi (parched to brown) 12kg, Pericarpium Citri Reticulatae 6kg, Fructus Amomi 4kg, standby;
B), add 6 times of amount 70% ethanol extractions twice, merging filtrate with Fructus Crataegi (parched to brown), Pericarpium Citri Reticulatae, Fructus Amomi;
C) filtrate recycling ethanol is evaporated to relative density and measures 1.25-1.30 down for 60 ℃, and drying under reduced pressure makes dry extract;
D) pulverize, cross 80 mesh sieves;
E) add hyprolose, calcium hydrogen phosphate, Heavy Magnesium Carbonate, polyvinylpolypyrrolidone, aspartame, mixing is granulated in right amount with 95% ethanol, drying, and tabletting promptly gets dispersible tablet.
Embodiment 3:
The preparation of the effervescent tablet of Chinese medicine composition of the present invention
A) take by weighing Fructus Crataegi (parched to brown) 12kg, Pericarpium Citri Reticulatae 6kg, Fructus Amomi 4kg, standby;
B), add 6 times of amount 70% ethanol extractions twice, merging filtrate with Fructus Crataegi (parched to brown), Pericarpium Citri Reticulatae, Fructus Amomi;
C) filtrate recycling ethanol is evaporated to relative density and measures 1.25-1.30 down for 60 ℃, and drying under reduced pressure makes dry extract;
D) pulverize, cross 80 mesh sieves;
E) add tartaric acid, sodium bicarbonate, Aspartane, xylitol, dehydrated alcohol is granulated, and drying adds PEG4000, mix homogeneously, and the system granule, drying, compacting promptly gets effervescent tablet in flakes.
Embodiment 4:
The preparation of the capsule of Chinese medicine composition of the present invention
A) take by weighing Fructus Crataegi (parched to brown) 12kg, Pericarpium Citri Reticulatae 6kg, Fructus Amomi 4kg, standby;
B), add 6 times of amount 70% ethanol extractions twice, merging filtrate with Fructus Crataegi (parched to brown), Pericarpium Citri Reticulatae, Fructus Amomi;
C) filtrate recycling ethanol is evaporated to relative density and measures 1.25-1.30 down for 60 ℃, and drying under reduced pressure makes dry extract;
D) pulverize, cross 80 mesh sieves;
E) add lactose, mix homogeneously, encapsulated, polishing, packing promptly gets capsule.
Embodiment 5:
The preparation of the capsule of Chinese medicine composition of the present invention
A) take by weighing Fructus Crataegi (parched to brown) 15kg, Pericarpium Citri Reticulatae 8kg, Fructus Amomi 6kg, standby;
B), add 8 times of amount 70% ethanol extractions twice, merging filtrate with Fructus Crataegi (parched to brown), Pericarpium Citri Reticulatae, Fructus Amomi;
C) filtrate recycling ethanol is evaporated to relative density and measures 1.25-1.30 down for 60 ℃, and drying under reduced pressure makes dry extract;
D) pulverize, cross 80 mesh sieves;
E) add an amount of dextrin, sucrose, evenly mixed, adding ethanol is wetting agent, granulate, and drying, granulate is made granule.
Claims (5)
1. the Chinese medicine composition with facilitating digestion function is characterized in that, it is to be made by following bulk drugs: Fructus Crataegi (parched to brown) 9-12kg, Pericarpium Citri Reticulatae 3-9kg, Fructus Amomi 3-6kg.
2. according to the Chinese medicine composition of claim 1, it is characterized in that it is to be made by following bulk drugs: Fructus Crataegi (parched to brown) 12kg, Pericarpium Citri Reticulatae 6kg, Fructus Amomi 4kg.
3. the preparation method of claim 1 or 2 described Chinese medicine compositions is characterized in that, this method is:
Fructus Crataegi (parched to brown), Pericarpium Citri Reticulatae, Fructus Amomi, adding ethanol extracts, extracting solution is concentrated, dry, make dry extract, be ground into powder, add various conventional adjuvant required when preparing different dosage form, as diluent, disintegrating agent, excipient, binding agent, lubricant, surfactant, filler, antiseptic, stabilizing agent, correctives, thickening agent, fluidizer etc., method of Chinese medicinal with routine is prepared into any peroral dosage form commonly used, as tablet, dispersible tablet, effervescent tablet, oral cavity disintegration tablet, buccal tablet, chewable tablet, capsule, microcapsule, granule, pill, powder, drop pill, slow releasing preparation, controlled release preparation etc.
4. according to the described preparation of drug combination method of claim 3, it is characterized in that this method is:
Fructus Crataegi (parched to brown) just, Pericarpium Citri Reticulatae, Fructus Amomi, add twice of 6 times of amount 70% ethanol extraction, filter, merging filtrate, reclaim ethanol, be evaporated to relative density and measure 1.25-1.30 down for 60 ℃, drying under reduced pressure, make dry extract, be ground into fine powder, add various conventional adjuvant required when preparing different dosage form, as diluent, disintegrating agent, excipient, binding agent, lubricant, surfactant, filler, antiseptic, stabilizing agent, correctives, thickening agent, fluidizer etc., method of Chinese medicinal with routine is prepared into any peroral dosage form commonly used, as tablet, dispersible tablet, effervescent tablet, oral cavity disintegration tablet, buccal tablet, chewable tablet, capsule, microcapsule, granule, pill, powder, drop pill, slow releasing preparation, controlled release preparation etc.
5. claim 1 or 2 described Chinese medicine compositions are used to prepare the medicine with facilitating digestion function or the application of health food.
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Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103652925A (en) * | 2013-12-25 | 2014-03-26 | 广西博士海意信息科技有限公司 | Appetite promoting and spleen strengthening composition |
| CN103990050A (en) * | 2014-04-22 | 2014-08-20 | 安徽省太湖山中药饮片有限公司 | Basil seed and villous amomum fruit effervescent tablet and preparation method thereof |
| CN104587367A (en) * | 2015-01-14 | 2015-05-06 | 唐慎华 | Traditional Chinese medicine for treating infantile malnutrition |
| CN107048132A (en) * | 2017-06-20 | 2017-08-18 | 哈尔滨工业大学 | A kind of fructus amomi compound beverage for improving human digestive function and preparation method thereof |
| CN112602863A (en) * | 2020-12-18 | 2021-04-06 | 高州市高能生物科技有限公司 | A beverage |
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2009
- 2009-01-20 CN CN2009100772063A patent/CN101780246B/en not_active Expired - Fee Related
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103652925A (en) * | 2013-12-25 | 2014-03-26 | 广西博士海意信息科技有限公司 | Appetite promoting and spleen strengthening composition |
| CN103990050A (en) * | 2014-04-22 | 2014-08-20 | 安徽省太湖山中药饮片有限公司 | Basil seed and villous amomum fruit effervescent tablet and preparation method thereof |
| CN104587367A (en) * | 2015-01-14 | 2015-05-06 | 唐慎华 | Traditional Chinese medicine for treating infantile malnutrition |
| CN107048132A (en) * | 2017-06-20 | 2017-08-18 | 哈尔滨工业大学 | A kind of fructus amomi compound beverage for improving human digestive function and preparation method thereof |
| CN112602863A (en) * | 2020-12-18 | 2021-04-06 | 高州市高能生物科技有限公司 | A beverage |
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