CN101772486B - 杀真菌剂n-6元稠合(杂)芳基-亚甲基-n-环烷基羧酰胺衍生物 - Google Patents
杀真菌剂n-6元稠合(杂)芳基-亚甲基-n-环烷基羧酰胺衍生物 Download PDFInfo
- Publication number
- CN101772486B CN101772486B CN200880101329XA CN200880101329A CN101772486B CN 101772486 B CN101772486 B CN 101772486B CN 200880101329X A CN200880101329X A CN 200880101329XA CN 200880101329 A CN200880101329 A CN 200880101329A CN 101772486 B CN101772486 B CN 101772486B
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- CN
- China
- Prior art keywords
- methyl
- alkyl
- represent
- formula
- halogen atoms
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/36—Oxygen or sulfur atoms
- C07D207/40—2,5-Pyrrolidine-diones
- C07D207/416—2,5-Pyrrolidine-diones with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to other ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D231/16—Halogen atoms or nitro radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D231/18—One oxygen or sulfur atom
- C07D231/20—One oxygen atom attached in position 3 or 5
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D307/56—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D333/38—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Plural Heterocyclic Compounds (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyrrole Compounds (AREA)
- Heterocyclic Compounds Containing Sulfur Atoms (AREA)
- Furan Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201310041976.9A CN103172570B (zh) | 2007-07-31 | 2008-07-31 | 杀真菌剂n-6元稠合(杂)芳基-亚甲基-n-环烷基羧酰胺衍生物 |
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP07356105 | 2007-07-31 | ||
| EP07356105.2 | 2007-07-31 | ||
| EP08356061.5 | 2008-04-16 | ||
| EP08356061 | 2008-04-16 | ||
| PCT/EP2008/060040 WO2009016221A1 (en) | 2007-07-31 | 2008-07-31 | Fungicide n-6-membered fused (hetero)aryl-methylene-n-cycloalkyl carboxamide derivatives |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201310041976.9A Division CN103172570B (zh) | 2007-07-31 | 2008-07-31 | 杀真菌剂n-6元稠合(杂)芳基-亚甲基-n-环烷基羧酰胺衍生物 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN101772486A CN101772486A (zh) | 2010-07-07 |
| CN101772486B true CN101772486B (zh) | 2013-03-20 |
Family
ID=39938207
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN200880101329XA Expired - Fee Related CN101772486B (zh) | 2007-07-31 | 2008-07-31 | 杀真菌剂n-6元稠合(杂)芳基-亚甲基-n-环烷基羧酰胺衍生物 |
| CN201310041976.9A Expired - Fee Related CN103172570B (zh) | 2007-07-31 | 2008-07-31 | 杀真菌剂n-6元稠合(杂)芳基-亚甲基-n-环烷基羧酰胺衍生物 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201310041976.9A Expired - Fee Related CN103172570B (zh) | 2007-07-31 | 2008-07-31 | 杀真菌剂n-6元稠合(杂)芳基-亚甲基-n-环烷基羧酰胺衍生物 |
Country Status (17)
| Country | Link |
|---|---|
| US (1) | US8226966B2 (enExample) |
| EP (1) | EP2185507B1 (enExample) |
| JP (1) | JP5563453B2 (enExample) |
| CN (2) | CN101772486B (enExample) |
| AR (1) | AR067744A1 (enExample) |
| AT (1) | ATE555090T1 (enExample) |
| AU (1) | AU2008281773B2 (enExample) |
| BR (1) | BRPI0813022B1 (enExample) |
| CA (1) | CA2692696A1 (enExample) |
| CL (1) | CL2008002241A1 (enExample) |
| CO (1) | CO6160265A2 (enExample) |
| ES (1) | ES2383571T3 (enExample) |
| MX (1) | MX2010001005A (enExample) |
| PL (1) | PL2185507T3 (enExample) |
| RU (1) | RU2440982C2 (enExample) |
| UA (1) | UA98652C2 (enExample) |
| WO (1) | WO2009016221A1 (enExample) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103172570A (zh) * | 2007-07-31 | 2013-06-26 | 拜尔农科股份公司 | 杀真菌剂n-6元稠合(杂)芳基-亚甲基-n-环烷基羧酰胺衍生物 |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PT2182800E (pt) * | 2007-07-31 | 2011-05-16 | Bayer Cropscience Ag | N-cicloalquil-benzil-tiocarboxamidas, ou derivados ncicloalquil- benzil-n?-substitu?dos-amidina fungicidas |
| AR076839A1 (es) | 2009-05-15 | 2011-07-13 | Bayer Cropscience Ag | Derivados fungicidas de pirazol carboxamidas |
| EP2251331A1 (en) | 2009-05-15 | 2010-11-17 | Bayer CropScience AG | Fungicide pyrazole carboxamides derivatives |
| AU2011260333B2 (en) | 2010-06-03 | 2014-07-24 | Bayer Cropscience Ag | N-[(het)arylalkyl)] pyrazole (thio)carboxamides and their heterosubstituted analogues |
| ES2533026T3 (es) * | 2010-06-03 | 2015-04-07 | Bayer Intellectual Property Gmbh | N-[(het)arilalquil)]pirazol (tio)carboxamidas y sus análogos heterosustituidos |
| CA2806121C (en) | 2010-09-21 | 2018-10-09 | Eisai R&D Management Co., Ltd. | Pharmaceutical composition |
| CA2815142A1 (en) * | 2010-10-21 | 2012-04-26 | Juergen Benting | 1-(heterocyclic carbonyl)-2-substituted pyrrolidines |
| MX2013004278A (es) * | 2010-10-21 | 2013-06-05 | Bayer Ip Gmbh | N-bencil carboxamidas heterociclicas. |
| EP2635564B1 (en) * | 2010-11-02 | 2017-04-26 | Bayer Intellectual Property GmbH | N-hetarylmethyl pyrazolylcarboxamides |
| BR112013012080A2 (pt) | 2010-11-15 | 2016-07-19 | Bayer Ip Gmbh | n-aril pirazol (tio) carboxamidas |
| CN105339353B (zh) * | 2013-06-26 | 2018-08-10 | 拜耳作物科学股份公司 | N-环烷基-n-[(稠合苯基)亚甲基]-(硫代)甲酰胺衍生物 |
| KR20160072184A (ko) * | 2013-10-16 | 2016-06-22 | 바이엘 크롭사이언스 악티엔게젤샤프트 | N-시클로알킬-n-(비헤테로시클릴메틸렌)-(티오)카르복사미드 유도체 |
| EA201792551A1 (ru) * | 2015-05-21 | 2018-05-31 | Байер Кропсайенс Акциенгезельшафт | Фунгицидные n-циклоалкил-n-{[орто-(1-замещенный циклоалкил)гетероарил]метил}(тио)карбоксамиды |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2004074259A1 (en) * | 2003-02-19 | 2004-09-02 | Neurogen Corporation | Aryl acid pyrimidinyl methyl amides, pyridazinyl methyl amides and related compounds |
| WO2006120224A1 (en) * | 2005-05-13 | 2006-11-16 | Bayer Cropscience Sa | Fungicide 2-pyridyl-methylene-carboxamide derivatives |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3513259A1 (de) * | 1985-04-13 | 1986-10-23 | Bayer Ag, 5090 Leverkusen | Heterocyclische amid-derivate |
| JPH0517062A (ja) | 1991-07-11 | 1993-01-26 | Ace Denken:Kk | 紙片の搬送スタツク装置 |
| IL103614A (en) | 1991-11-22 | 1998-09-24 | Basf Ag | Carboxamides for controlling botrytis and certain novel such compounds |
| GB9919588D0 (en) | 1999-08-18 | 1999-10-20 | Hoechst Schering Agrevo Gmbh | Fungicidal compounds |
| GB0101996D0 (en) * | 2001-01-25 | 2001-03-14 | Syngenta Participations Ag | Organtic compounds |
| US20040097557A1 (en) * | 2002-11-13 | 2004-05-20 | Duffy Joseph L. | Cyanothiophene derivatives, compositions containing such compounds and methods of use |
| AR056882A1 (es) * | 2006-02-01 | 2007-10-31 | Bayer Cropscience Sa | Derivados del fungicida n- cicloalquil- bencil- amida |
| TW200803855A (en) | 2006-02-24 | 2008-01-16 | Kalypsys Inc | Quinolones useful as inducible nitric oxide synthase inhibitors |
| WO2008065500A2 (en) * | 2006-11-30 | 2008-06-05 | Pfizer Products Inc. | Heteroaryl amides as type i glycine transport inhibitors |
| CL2008002241A1 (es) * | 2007-07-31 | 2009-12-28 | Bayer Cropscience Sa | Compuestos derivados de (hetero)aril-metilen-n-cicloalquil carboxamida condensados de 6 elementos con n-sustituido; composicion funguicida que comprende uno de dichos compuestos; y metodo para el control hongos fitopatogenos de cultivos agricolas. |
-
2008
- 2008-07-30 CL CL2008002241A patent/CL2008002241A1/es unknown
- 2008-07-30 AR ARP080103302A patent/AR067744A1/es unknown
- 2008-07-31 BR BRPI0813022A patent/BRPI0813022B1/pt not_active IP Right Cessation
- 2008-07-31 RU RU2010107281/04A patent/RU2440982C2/ru not_active IP Right Cessation
- 2008-07-31 PL PL08786665T patent/PL2185507T3/pl unknown
- 2008-07-31 CA CA 2692696 patent/CA2692696A1/en not_active Abandoned
- 2008-07-31 ES ES08786665T patent/ES2383571T3/es active Active
- 2008-07-31 AT AT08786665T patent/ATE555090T1/de active
- 2008-07-31 AU AU2008281773A patent/AU2008281773B2/en not_active Ceased
- 2008-07-31 WO PCT/EP2008/060040 patent/WO2009016221A1/en not_active Ceased
- 2008-07-31 US US12/452,921 patent/US8226966B2/en not_active Expired - Fee Related
- 2008-07-31 MX MX2010001005A patent/MX2010001005A/es active IP Right Grant
- 2008-07-31 EP EP08786665A patent/EP2185507B1/en not_active Not-in-force
- 2008-07-31 UA UAA201000538A patent/UA98652C2/uk unknown
- 2008-07-31 JP JP2010518674A patent/JP5563453B2/ja not_active Expired - Fee Related
- 2008-07-31 CN CN200880101329XA patent/CN101772486B/zh not_active Expired - Fee Related
- 2008-07-31 CN CN201310041976.9A patent/CN103172570B/zh not_active Expired - Fee Related
-
2010
- 2010-02-24 CO CO10022117A patent/CO6160265A2/es unknown
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2004074259A1 (en) * | 2003-02-19 | 2004-09-02 | Neurogen Corporation | Aryl acid pyrimidinyl methyl amides, pyridazinyl methyl amides and related compounds |
| WO2006120224A1 (en) * | 2005-05-13 | 2006-11-16 | Bayer Cropscience Sa | Fungicide 2-pyridyl-methylene-carboxamide derivatives |
Non-Patent Citations (2)
| Title |
|---|
| Itaru Okada et al..吡唑-5-羧酰胺衍生物的合成和杀螨活性.《农药译丛》.1993,第15卷(第3期),第32-37页. * |
| 黄青春.羧酰胺类杀菌剂的活性及其机理研究进展.《世界农药》.2004,第26卷(第4期),第23-27页. * |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103172570A (zh) * | 2007-07-31 | 2013-06-26 | 拜尔农科股份公司 | 杀真菌剂n-6元稠合(杂)芳基-亚甲基-n-环烷基羧酰胺衍生物 |
| CN103172570B (zh) * | 2007-07-31 | 2015-09-30 | 拜尔农科股份公司 | 杀真菌剂n-6元稠合(杂)芳基-亚甲基-n-环烷基羧酰胺衍生物 |
Also Published As
| Publication number | Publication date |
|---|---|
| CA2692696A1 (en) | 2009-02-05 |
| CN101772486A (zh) | 2010-07-07 |
| EP2185507A1 (en) | 2010-05-19 |
| CN103172570B (zh) | 2015-09-30 |
| AR067744A1 (es) | 2009-10-21 |
| AU2008281773B2 (en) | 2013-05-02 |
| JP5563453B2 (ja) | 2014-07-30 |
| RU2440982C2 (ru) | 2012-01-27 |
| EP2185507B1 (en) | 2012-04-25 |
| US20100144785A1 (en) | 2010-06-10 |
| CO6160265A2 (es) | 2010-05-20 |
| RU2010107281A (ru) | 2011-09-20 |
| BRPI0813022A2 (pt) | 2014-12-23 |
| MX2010001005A (es) | 2010-03-09 |
| BRPI0813022B1 (pt) | 2019-02-05 |
| PL2185507T3 (pl) | 2012-09-28 |
| JP2010534716A (ja) | 2010-11-11 |
| US8226966B2 (en) | 2012-07-24 |
| UA98652C2 (uk) | 2012-06-11 |
| AU2008281773A1 (en) | 2009-02-05 |
| CN103172570A (zh) | 2013-06-26 |
| CL2008002241A1 (es) | 2009-12-28 |
| ATE555090T1 (de) | 2012-05-15 |
| ES2383571T3 (es) | 2012-06-22 |
| WO2009016221A1 (en) | 2009-02-05 |
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