CN101743253B - 神经毡蛋白片段与神经毡蛋白抗体复合物的晶体结构 - Google Patents
神经毡蛋白片段与神经毡蛋白抗体复合物的晶体结构 Download PDFInfo
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- CN101743253B CN101743253B CN2007800537931A CN200780053793A CN101743253B CN 101743253 B CN101743253 B CN 101743253B CN 2007800537931 A CN2007800537931 A CN 2007800537931A CN 200780053793 A CN200780053793 A CN 200780053793A CN 101743253 B CN101743253 B CN 101743253B
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/71—Receptors; Cell surface antigens; Cell surface determinants for growth factors; for growth regulators
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/475—Growth factors; Growth regulators
- C07K14/515—Angiogenesic factors; Angiogenin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K40/00—Cellular immunotherapy
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A—HUMAN NECESSITIES
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- A61P13/12—Drugs for disorders of the urinary system of the kidneys
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A—HUMAN NECESSITIES
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- A61P27/02—Ophthalmic agents
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A—HUMAN NECESSITIES
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- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
- A61P31/22—Antivirals for DNA viruses for herpes viruses
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- A—HUMAN NECESSITIES
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- A61P35/00—Antineoplastic agents
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P7/06—Antianaemics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2863—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
- C07K16/42—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against immunoglobulins
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2299/00—Coordinates from 3D structures of peptides, e.g. proteins or enzymes
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/55—Fab or Fab'
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Toxicology (AREA)
- Pulmonology (AREA)
- Oncology (AREA)
- Virology (AREA)
- Cell Biology (AREA)
- Vascular Medicine (AREA)
- Urology & Nephrology (AREA)
- Cardiology (AREA)
- Communicable Diseases (AREA)
- Heart & Thoracic Surgery (AREA)
- Dermatology (AREA)
- Hematology (AREA)
- Biotechnology (AREA)
- Pain & Pain Management (AREA)
- Physical Education & Sports Medicine (AREA)
- Diabetes (AREA)
- Reproductive Health (AREA)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201310122441.4A CN103193888B (zh) | 2007-05-17 | 2007-05-17 | 神经毡蛋白片段与神经毡蛋白抗体复合物的晶体结构 |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PCT/US2007/069185 WO2008143666A2 (en) | 2007-05-17 | 2007-05-17 | Crystal structures of neuropilin fragments and neuropilin-antibody complexes |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201310122441.4A Division CN103193888B (zh) | 2007-05-17 | 2007-05-17 | 神经毡蛋白片段与神经毡蛋白抗体复合物的晶体结构 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN101743253A CN101743253A (zh) | 2010-06-16 |
| CN101743253B true CN101743253B (zh) | 2013-05-08 |
Family
ID=38963109
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN2007800537931A Expired - Fee Related CN101743253B (zh) | 2007-05-17 | 2007-05-17 | 神经毡蛋白片段与神经毡蛋白抗体复合物的晶体结构 |
Country Status (13)
| Country | Link |
|---|---|
| US (2) | US8318163B2 (https=) |
| EP (1) | EP2158215B1 (https=) |
| JP (1) | JP2010530359A (https=) |
| KR (1) | KR101523788B1 (https=) |
| CN (1) | CN101743253B (https=) |
| AU (1) | AU2007353779B2 (https=) |
| BR (1) | BRPI0721707A2 (https=) |
| CA (1) | CA2687556A1 (https=) |
| ES (1) | ES2541051T3 (https=) |
| IL (1) | IL201983A (https=) |
| MX (1) | MX2009012282A (https=) |
| RU (1) | RU2012109383A (https=) |
| WO (1) | WO2008143666A2 (https=) |
Families Citing this family (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| UY31800A (es) * | 2008-05-05 | 2009-11-10 | Smithkline Beckman Corp | Metodo de tratamiento de cancer usando un inhibidor de cmet y axl y un inhibidor de erbb |
| BR112012027995A2 (pt) | 2010-06-18 | 2017-01-10 | Genentech Inc | anticorpo e ácido nucleíco isolado, célula hospedeira, método de produção de um anticorpo, imunoconjugado, formulação farmacêutica, uso do anticorpo, método de tratamento de um indivíduo com câncer, de um indivíduo possuíndo um distúrbio imune, de inibição da angiogênese e para inibir a ativação constitutiva de axl |
| JP6130307B2 (ja) | 2011-03-17 | 2017-05-17 | ザ ユニバーシティ オブ バーミンガム | 再指向性免疫療法 |
| PL3489261T3 (pl) | 2012-08-24 | 2021-08-16 | The Regents Of The University Of California | Przeciwciała i szczepionki do stosowania w leczeniu nowotworów z ekspresją ROR1 i w hamowaniu przerzutu |
| CN103992377B (zh) * | 2013-02-18 | 2017-05-17 | 上海市第一人民医院 | 一种抑制新生血管的小肽及其应用 |
| CN103992376B (zh) * | 2013-02-18 | 2017-05-17 | 上海市第一人民医院 | 一种抑制新生血管的小肽及其应用 |
| CN105378075B (zh) | 2013-03-15 | 2022-04-05 | Atyr 医药公司 | 组氨酰-trna合成酶-fc缀合物 |
| MX2016015569A (es) | 2014-06-02 | 2017-04-25 | Children´S Medical Center Corp | Metodos y composiciones para inmunomodulacion. |
| JP6692816B2 (ja) | 2014-09-05 | 2020-05-13 | アールエスイーエム,リミティド パートナーシップ | 炎症を処置および予防するための組成物および方法 |
| WO2017119434A1 (ja) | 2016-01-06 | 2017-07-13 | 株式会社オーダーメードメディカルリサーチ | Vegfとnrp1との結合を阻害する抗体 |
| WO2017119435A1 (ja) | 2016-01-06 | 2017-07-13 | 株式会社オーダーメードメディカルリサーチ | 高親和性抗vegf抗体 |
| IL299099B2 (en) | 2016-06-27 | 2025-07-01 | Univ California | Cancer treatment combinations |
| JOP20190134A1 (ar) * | 2016-12-23 | 2019-06-02 | Potenza Therapeutics Inc | بروتينات رابطة لمولد ضد مضادة لنيوروبيلين وطرق استخدامها |
| CN110536694A (zh) | 2017-04-20 | 2019-12-03 | Atyr 医药公司 | 用于治疗肺部炎症的组合物和方法 |
| US12215151B2 (en) | 2017-05-31 | 2025-02-04 | Stcube & Co., Inc. | Methods of treating cancer using antibodies and molecules that immunospecifically bind to BTN1A1 |
| CN110997724A (zh) | 2017-06-06 | 2020-04-10 | 斯特库伯株式会社 | 使用结合btn1a1或btn1a1-配体的抗体和分子治疗癌症的方法 |
| CA3096222A1 (en) | 2018-04-06 | 2019-10-10 | Atyr Pharma, Inc. | Compositions and methods comprising anti-nrp2 antibodies |
| CA3120800A1 (en) | 2018-12-17 | 2020-06-25 | Revitope Limited | Twin immune cell engager |
| TWI859339B (zh) * | 2019-09-24 | 2024-10-21 | 德商百靈佳殷格翰國際股份有限公司 | 抗nrp1a抗體及其用於治療眼或眼部疾病之用途 |
| CN114746120B (zh) | 2019-10-03 | 2024-07-30 | Atyr医药公司 | 包含抗nrp2抗体的组合物和方法 |
| GB202207116D0 (en) * | 2022-05-16 | 2022-06-29 | Quadram Inst Bioscience | Method and Compositions for Tumorigenesis Inhibition |
| CN114949224B (zh) * | 2022-06-06 | 2023-03-14 | 山东大学第二医院 | Nrp2激动剂在制备复发性流产治疗药物中的应用 |
Family Cites Families (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4816567A (en) * | 1983-04-08 | 1989-03-28 | Genentech, Inc. | Recombinant immunoglobin preparations |
| EP0397834B1 (en) * | 1988-10-28 | 2000-02-02 | Genentech, Inc. | Method for identifying active domains and amino acid residues in polypeptides and hormone variants |
| EP0368684B2 (en) | 1988-11-11 | 2004-09-29 | Medical Research Council | Cloning immunoglobulin variable domain sequences. |
| GB8928874D0 (en) | 1989-12-21 | 1990-02-28 | Celltech Ltd | Humanised antibodies |
| US5427908A (en) * | 1990-05-01 | 1995-06-27 | Affymax Technologies N.V. | Recombinant library screening methods |
| US5723286A (en) * | 1990-06-20 | 1998-03-03 | Affymax Technologies N.V. | Peptide library and screening systems |
| GB9015198D0 (en) * | 1990-07-10 | 1990-08-29 | Brien Caroline J O | Binding substance |
| US6172197B1 (en) * | 1991-07-10 | 2001-01-09 | Medical Research Council | Methods for producing members of specific binding pairs |
| CA2405246A1 (en) * | 1990-12-03 | 1992-06-11 | Genentech, Inc. | Enrichment method for variant proteins with alterred binding properties |
| DK0580737T3 (da) * | 1991-04-10 | 2004-11-01 | Scripps Research Inst | Heterodimere receptorbiblioteker ved anvendelse af phagemider |
| WO1994004679A1 (en) | 1991-06-14 | 1994-03-03 | Genentech, Inc. | Method for making humanized antibodies |
| EP1400536A1 (en) | 1991-06-14 | 2004-03-24 | Genentech Inc. | Method for making humanized antibodies |
| US5270170A (en) * | 1991-10-16 | 1993-12-14 | Affymax Technologies N.V. | Peptide library and screening method |
| US5733743A (en) * | 1992-03-24 | 1998-03-31 | Cambridge Antibody Technology Limited | Methods for producing members of specific binding pairs |
| BR9207175A (pt) | 1992-10-28 | 1995-12-12 | Genentech Inc | Composição contendo antagonista de fator de crescimento de célula endotelial vascular sequência aminoácida de anticorpo monoclonal polipeptídeo e método de tratamento de tumor em mamífero |
| ATE199392T1 (de) * | 1992-12-04 | 2001-03-15 | Medical Res Council | Multivalente und multispezifische bindungsproteine, deren herstellung und verwendung |
| IL117645A (en) | 1995-03-30 | 2005-08-31 | Genentech Inc | Vascular endothelial cell growth factor antagonists for use as medicaments in the treatment of age-related macular degeneration |
| EP2338915A3 (en) | 1997-04-07 | 2011-10-12 | Genentech, Inc. | Anti-VEGF antibodies |
| US20050106667A1 (en) * | 2003-08-01 | 2005-05-19 | Genentech, Inc | Binding polypeptides with restricted diversity sequences |
-
2007
- 2007-05-17 CN CN2007800537931A patent/CN101743253B/zh not_active Expired - Fee Related
- 2007-05-17 AU AU2007353779A patent/AU2007353779B2/en not_active Ceased
- 2007-05-17 KR KR1020097026233A patent/KR101523788B1/ko not_active Expired - Fee Related
- 2007-05-17 EP EP20070762242 patent/EP2158215B1/en active Active
- 2007-05-17 BR BRPI0721707-2A patent/BRPI0721707A2/pt not_active IP Right Cessation
- 2007-05-17 MX MX2009012282A patent/MX2009012282A/es active IP Right Grant
- 2007-05-17 US US12/598,625 patent/US8318163B2/en not_active Expired - Fee Related
- 2007-05-17 ES ES07762242.1T patent/ES2541051T3/es active Active
- 2007-05-17 WO PCT/US2007/069185 patent/WO2008143666A2/en not_active Ceased
- 2007-05-17 CA CA002687556A patent/CA2687556A1/en not_active Abandoned
- 2007-05-17 JP JP2010508353A patent/JP2010530359A/ja not_active Withdrawn
-
2009
- 2009-11-08 IL IL201983A patent/IL201983A/en not_active IP Right Cessation
-
2012
- 2012-03-12 RU RU2012109383/10A patent/RU2012109383A/ru not_active Application Discontinuation
- 2012-07-03 US US13/541,411 patent/US8466264B2/en not_active Expired - Fee Related
Non-Patent Citations (5)
| Title |
|---|
| GIGER R J ET AL.Neuropilin-2 is a receptor for semaphorin IV: insight into the structural basis of receptor function and specificity.《NEURON》.1998,第21卷(第5期),1079-1092. * |
| LEE CHRISTIAN C ET AL.Crystal structure of the human neuropilin-1 b1 domain.《STRUCTURE》.2003,第11卷(第1期),99-108. * |
| LIANG ET AL.Function Blocking Antibodies to Neuropilin-1 Generated from a Designed Human Synthetic Antibody Phage Library.《JOURNAL OF MOLECULAR BIOLOGY》.2007,第366卷(第3期),815-829. * |
| PAN QI ET AL.Blocking neuropilin-1 function has an additive effect with anti-VEGF to inhibit tumor growth.《CANCER CELL》.2007,第11卷(第1期),53-67. * |
| VANDER KOOI CRAIG W ET AL.Structural basis for ligand and heparin binding to neuropilin B domains.《PNAS》.2007,第104卷(第15期),6152-6157. * |
Also Published As
| Publication number | Publication date |
|---|---|
| KR20100020967A (ko) | 2010-02-23 |
| CN101743253A (zh) | 2010-06-16 |
| AU2007353779B2 (en) | 2013-11-07 |
| JP2010530359A (ja) | 2010-09-09 |
| HK1144580A1 (en) | 2011-02-25 |
| IL201983A (en) | 2015-03-31 |
| ES2541051T3 (es) | 2015-07-15 |
| IL201983A0 (en) | 2010-06-16 |
| US20100150919A1 (en) | 2010-06-17 |
| KR101523788B1 (ko) | 2015-06-26 |
| EP2158215A2 (en) | 2010-03-03 |
| US8466264B2 (en) | 2013-06-18 |
| AU2007353779A1 (en) | 2008-11-27 |
| US8318163B2 (en) | 2012-11-27 |
| MX2009012282A (es) | 2009-11-25 |
| RU2012109383A (ru) | 2013-09-20 |
| US20120322989A1 (en) | 2012-12-20 |
| WO2008143666A2 (en) | 2008-11-27 |
| BRPI0721707A2 (pt) | 2013-01-15 |
| WO2008143666A3 (en) | 2009-02-05 |
| CA2687556A1 (en) | 2008-11-27 |
| EP2158215B1 (en) | 2015-04-22 |
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