CN101732760A - Chitosan non-vessel stent and preparation method thereof - Google Patents
Chitosan non-vessel stent and preparation method thereof Download PDFInfo
- Publication number
- CN101732760A CN101732760A CN200910264239A CN200910264239A CN101732760A CN 101732760 A CN101732760 A CN 101732760A CN 200910264239 A CN200910264239 A CN 200910264239A CN 200910264239 A CN200910264239 A CN 200910264239A CN 101732760 A CN101732760 A CN 101732760A
- Authority
- CN
- China
- Prior art keywords
- vessel stent
- chitosan
- stent
- chitosan non
- preparation
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Images
Landscapes
- Materials For Medical Uses (AREA)
- Media Introduction/Drainage Providing Device (AREA)
Abstract
The invention belongs to the field of medical materials, in particular to chitosan non-vessel stent and preparation method thereof. The chitosan non-vessel stent is formed by weaving chitosan fibers. The stent is compatible with the traditional stent conduit delivery system. Because of being degraded per se in a human body, the chitosan non-vessel stent has environment protection without hurt on the human body, many excellent biological characteristics, huge social benefit and economic benefit, and is an ideal biological degradable material replacing metal stents.
Description
Technical field
The invention belongs to field of medical materials, be specifically related to chitosan non-vessel stent and preparation method thereof.
Background technology
At present clinical used non-vessel stent is metal rack, and the domestic demand several weeks taking-up of performing the operation once more in operation back has increased patient's misery and medical expense.Still the support that does not have at present the other biological degradation material.
Chitosan has many biological activitys, and known anti and operative scar after having antiinflammatory, blood fat reducing and being used for orthopaedics and obstetrics and gynecology operation clinically forms.Our experiment has confirmed that also chitosan has the smooth muscle cell of inhibition and fibroblast proliferation, promotes the effect of endotheliocyte and epidermal growth.Chitosan is described as the health-care food of 21st century, the 6th key element of life.
Summary of the invention
The purpose of this invention is to provide a kind of degradable chitosan non-vessel stent, this chitosan non-vessel stent not only can be degraded voluntarily, and implanting in patient's body need not second operation; And chitosan unique biological activity, have antiinflammatory, suppress fibroblast proliferation and promote the effect of epidermal growth, promoted the pathological changes healing, shortened the course of disease.
The said chitosan non-vessel stent of the present invention is to form with the chitin fiber braiding.
The silk footpath that is used for chitin fiber of the present invention can be 1.8 ± 0.2mm.
The manufacture method of above-mentioned chitosan non-vessel stent is: select the chitosan polymer spinned fiber of suitable mechanical for use, be woven into support then.Can adopt conventional Ω weaving method during making, support that makes and present scaffold tube delivery system compatibility.Except that the material difference, chitosan non-vessel stent of the present invention and existing non-blood vessel metal rack are at the textural basically identical of shape, and as Zigzag shape (zigzag) (Fig. 1), outward appearance likeness in form rim of a cup is trumpet-shaped cylinder.
It is narrow that chitosan non-vessel stent can be used for the tube chamber postoperative control of non-blood vessel, mainly makes tube chamber keep unimpeded.Chitosan non-vessel stent has been finished zoopery at present, has reached satisfied effect.
The present invention compares with existing metal rack and has the following advantages: domestic used metal rack mostly is the import support at present, and price of the present invention only is 1/10th of import; Chitosan non-vessel stent need not second operation and takes out; Metal rack has damage used to human body, and chitosan has the effect that suppresses fibroblast proliferation significantly and promote epidermal growth, has promoted the pathological changes healing.Because chitosan non-vessel stent can degrade in human body voluntarily, not only environmental protection but also harmless to human body, and have many good biological natures, be the desirable Biodegradable material of alternative metals support, thereby have great social benefit and economic benefit.
Description of drawings
Fig. 1 is the metal non-vessel stent
Fig. 2 is a chitosan non-vessel stent
The specific embodiment
The present invention is further described below in conjunction with drawings and Examples.
Employed in the present invention term unless other explanation is arranged, generally has the implication of those of ordinary skills' common sense.
Below in conjunction with concrete preparation embodiment and Application Example, and comparable data is described the present invention in further detail.Should be understood that these embodiment just in order to demonstrate the invention, but not limit the scope of the invention by any way.
In following embodiment, various processes of Xiang Ximiaoshuing and method are not conventional methods as known in the art.The source of agents useful for same, trade name and be necessary to list its constituent person indicate when occurring first that all used thereafter identical reagent if no special instructions, and is all identical with the content of indicating first.
Embodiment 1: the making of chitosan non-vessel stent
The chitosan raw material is provided by its victory biomaterial technical research institute of Shanghai.With the esophageal stents appear is example, adopts different stretch rates to make fiber, measures its mechanical performance, inside and outside degradation speed and dynamic process.Can use after the detection of biological compatibility is qualified.Its toxicological experiment sees Table 1.Chitin fiber silk footpath 1.8 ± 0.2mm, pressure that can bear and distraction force surpass 20 kPas, 10 above atmospheric pressure.Chitin fiber is woven into length 100 ± 3mm, and diameter 18 ± 2mm, rim of a cup are trumpet-shaped cylinder bracket (Fig. 2).
The toxicology of table 1. chitosan detects
Embodiment 2: the application of chitosan non-vessel stent
It is narrow that the support that the foregoing description 1 is made is used for non-flesh and blood pipe tube chamber postoperative control, makes tube chamber keep unimpeded, and degraded fully voluntarily in 24 weeks after surgery, need not second operation.
The invention is not restricted to these disclosed embodiments, the present invention will cover the scope described in the patent book, and the various modification of claim scope and equivalence variation.
Claims (5)
1. a non-vessel stent is characterized in that, is to form with the chitin fiber braiding.
2. non-vessel stent according to claim 1 is characterized in that, the silk footpath of chitin fiber is 1.8 ± 0.2mm.
3. require 1 described non-vessel stent as requested, it is characterized in that, the shape of support is that rim of a cup is trumpet-shaped cylinder, length 100 ± 3mm, diameter 18 ± 2mm.
4. a method for preparing the described non-vessel stent of claim 1 is characterized in that, is by with the chitosan polymer spinned fiber, is woven into then to form.
5. preparation method according to claim 4 is characterized in that, is to adopt the Ω weaving method to be made into support.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN200910264239A CN101732760A (en) | 2009-12-31 | 2009-12-31 | Chitosan non-vessel stent and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN200910264239A CN101732760A (en) | 2009-12-31 | 2009-12-31 | Chitosan non-vessel stent and preparation method thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN101732760A true CN101732760A (en) | 2010-06-16 |
Family
ID=42457126
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN200910264239A Pending CN101732760A (en) | 2009-12-31 | 2009-12-31 | Chitosan non-vessel stent and preparation method thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN101732760A (en) |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1319379A (en) * | 2001-02-19 | 2001-10-31 | 南通医学院 | Medical artificial nerve graft and preparation process thereof |
| CN1385217A (en) * | 2002-05-30 | 2002-12-18 | 南通医学院 | Chitosan medical nerve and productive method thereof |
| CN1398643A (en) * | 2002-08-12 | 2003-02-26 | 天津大学 | Prepn process of multi-component hybridized 3D woven myotendinous rack material |
| CN1966095A (en) * | 2006-08-16 | 2007-05-23 | 徐志飞 | Biodegradable reticular artificial chest wall and preparation method thereof |
-
2009
- 2009-12-31 CN CN200910264239A patent/CN101732760A/en active Pending
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1319379A (en) * | 2001-02-19 | 2001-10-31 | 南通医学院 | Medical artificial nerve graft and preparation process thereof |
| CN1385217A (en) * | 2002-05-30 | 2002-12-18 | 南通医学院 | Chitosan medical nerve and productive method thereof |
| CN1398643A (en) * | 2002-08-12 | 2003-02-26 | 天津大学 | Prepn process of multi-component hybridized 3D woven myotendinous rack material |
| CN1966095A (en) * | 2006-08-16 | 2007-05-23 | 徐志飞 | Biodegradable reticular artificial chest wall and preparation method thereof |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN104383606B (en) | A kind of high-strength high-elasticity intravascular stent and preparation method thereof | |
| CN101654537B (en) | Carboxymethyl chitosan/polyvinyl alcohol compound sponge and preparation method thereof | |
| CN101234041A (en) | Atrial septal defect plugging device knitted by degradable material | |
| CN104403170A (en) | Medical LDPE(low-density polyethylene) antibacterial plastic and preparation method thereof | |
| CN100372578C (en) | Composite support material, composite support, and its production process | |
| Mohammadzadeh et al. | A novel egg-shell membrane based hybrid nanofibrous scaffold for cutaneous tissue engineering | |
| CN102335461A (en) | Controllable safe human body pipeline bracket made of PLA (Poly Lactic Acid)/PCLA (Polycaprolactone Lactide) degradable composite material and production method thereof | |
| CN201389101Y (en) | Recoverable biliary tract bracket | |
| CN110507842B (en) | Bacterial cellulose/hyaluronic acid/epsilon-polylysine functional dressing and preparation method thereof | |
| CN104448479A (en) | Medical antibacterial agent modified LDPE and preparation method thereof | |
| CN106344952A (en) | Compound dressing with high liquid absorption performance and preparation method of compound dressing | |
| CN110124086A (en) | A kind of composite nano fiber pad, hydrogel/sponge dressing and preparation method and application | |
| Liu et al. | Biomedical applications of bacterial cellulose based composite hydrogels | |
| CN1775302A (en) | Chitose-gelatine sponge wound dressing preparing method | |
| CN105999376A (en) | Surgical suture with effects of easing pain and resisting bacteria | |
| CN101584880A (en) | Material for repairing defect of human body bone and preparation method thereof | |
| CN104403169A (en) | Medical LDPE(low-density polyethylene) antibacterial material and preparation method thereof | |
| TW200424216A (en) | Alginate sponge and preparation method thereof | |
| CN104415402A (en) | Three-dimensional patch used for nerve regeneration and dura mater repairing | |
| CN101732760A (en) | Chitosan non-vessel stent and preparation method thereof | |
| CN106366589B (en) | Degradable composite material and application its intrauterine device and preparation method thereof | |
| CN103301504A (en) | Preparation method of gamma-polyglutamate/sericin hydrogel dressing | |
| CN101732764A (en) | Chitosan stent and preparation method thereof | |
| CN202376260U (en) | Nose prosthesis | |
| CN102380131B (en) | Degradable or detachable digestive tract bracket |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C02 | Deemed withdrawal of patent application after publication (patent law 2001) | ||
| WD01 | Invention patent application deemed withdrawn after publication |
Application publication date: 20100616 |