CN1398643A - Prepn process of multi-component hybridized 3D woven myotendinous rack material - Google Patents
Prepn process of multi-component hybridized 3D woven myotendinous rack material Download PDFInfo
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- CN1398643A CN1398643A CN 02125468 CN02125468A CN1398643A CN 1398643 A CN1398643 A CN 1398643A CN 02125468 CN02125468 CN 02125468 CN 02125468 A CN02125468 A CN 02125468A CN 1398643 A CN1398643 A CN 1398643A
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Abstract
The present invention belongs to the rack material preparing technology in tissue engineering. Polyglycollide, polylactide or their mixture copolymer fatty polyester fiber material is woven into rope-like 3D myotendinous rack material and there is chitosan, chitin or glutin of 0-30% in the fiber. The fatty polyester fiber has circular, ring or opened C-shaped cross section and the specially shaped C-shaped fiber accounts for 0-20%. It has the advantages of high tension strength, controllable degrading speed and good cell affinity.
Description
Technical field
The present invention relates to a kind of preparation method of multi-component hybridized 3 D woven myotendinous rack material, belong to the tissue engineering bracket material technology of preparing.
Background technology
The raw material of tissue engineering bracket material comprises natural material and synthesising biological degradable polymer material two big classes.Compare with natural macromolecular, the biodegradable fatty polyester is as the good mechanical performance of poly-Acetic acid, hydroxy-, bimol. cyclic ester (PGA), polylactide (PLA) and copolymer (PLGA) thereof, and the fiber that is spun into by these polymer can be processed into the 3 D weaving timbering material.Through reasonably design and processing, can be made into said three-dimensional body, and be suitable for the reconstruction of tissues such as tendon, ligament, cartilage, bone and skin with certain interstitial space and geometric shape.
The through engineering approaches of relevant tendon and ligament tissue is rebuild, the Frank Ko of U.S. Drexel university and CatoLaurencin seminar, carried out with PLGA (50: 50) three-dimensional braid is engineered ligament research (the Laurencin CT of timbering material, Ambrosio AMA, Borden MD, et a1. " Tissue engineering:Orthopedic applications ", Annu Rev Biomed Eng, 1999; 1:19-46); The James Goh seminar of NUS, with PLGA (50: 50) three dimensional needle fabric is that support has been studied damaged reparation (the Goh JCH of rabbit heel string, Hin LE, Chan C. " Tissue engineering approach in the repair andregeneration of tendons and ligaments ", International Conference on Materials forAdvanced Technologies, Singapore, 2001.Symposium B:Biomaterials and TissueEngineering B1-04-KE).The domestic Yang Zhi of Sichuan University penetrating judgment is awarded seminar, many-sided research (Yang ZM has been carried out in reparation to the tendon tissue through engineering approaches, Xie HQ, Li T. " Tissue engineering of themusculo-skeletal system-basic research and clinical applications ", Hand Surgery, 2000,5 (1): 49-55), and studied PPDO by different degradation speeds, histocompatibility (the Qu Yanlong of the shuffling thing that PLGA and polycaprolactone biodegradable fiber constitute, Yang Zhiming, Xie Huiqi, Zhu Weinan, Lei Song. " tissue engineering produced tendon is to the influence of t lymphocyte subset group and receptor thereof ", Chinese reconstruction surgical magazine, 2001,15 (2): 113-117).The Tissue Engineering Study center Cao Yilin of Shanghai Second Emdical University professor seminar is that the tendon tissue engineering of support has carried out studying (Shang Qingxin to the PGA non-woven mat, Cao Yilin, " brand-new forward position---the organizational project of bioengineering field ", introduce external medical technology and equipment, 1999, (11): 11-15,27).In Guangzhou, utilize Crinis Carbonisatus as the existing patent of invention (Cao Qidi, CN1191754, Nanfang Hospital) of the research of artificial tendon.
Existing three-dimensional degradable braided support, its degradation speed is wayward, does not relate to the load of bioactive substance.
Summary of the invention
The object of the present invention is to provide a kind of preparation method of multi-component hybridized 3 D woven myotendinous rack material, have the advantage that tensile strength is good, degradation speed is adjustable, cellular affinity is good according to the prepared artificial tendon material of this method.
For achieving the above object, the present invention is realized by following technical proposals.Mainly respectively containing a certain proportion of copolymer aliphatic poly ester fiber with poly-Acetic acid, hydroxy-, bimol. cyclic ester, polylactide or they is material, is woven into column-braid shape rope form 3 D weaving tendon tissue engineering scaffold material with circular 3 D weaving method of 1 * 1 four step.It is characterized in that also comprising in the fiber fiber of chitosan or chitin or gelatin, their shared mass percents are 0～30%.The cross section of aliphatic poly ester fiber is a typical circular, or the heterotypic fibre of hollow circular ring shape and " C " font opening, and wherein the heterotypic fibre mass percent is 0～20%.
The present invention has the advantage that tensile strength is good, degradation speed is adjustable, cellular affinity is good.
The specific embodiment:
Get PLLA 20g, 50 ℃ of following vacuum drying 48h carry out melt spinning with single screw extrusion machine and hot drafting system, and 180～240 ℃ of extrusion temperatures, drawing temperature are 120～160 ℃.Making diameter is the PLLA fiber of 0.08mm～0.18mm.Use O type and C type nozzle aperture instead, under same condition, make hollow and C type PLLA fiber that diameter is 0.10mm～0.23mm.
Embodiment 1:
Get above-mentioned melt-spun PLLA fiber a little (diameter is 0.1mm), and to get PGA fiber and the diameter that an amount of diameter is 0.02mm be the chitin fiber of 0.01mm, it is long all to be cut into 500mm.PLLA, PGA and each 2,80 and 160 of the chitin fibers got respectively after the sanction are formed yarns, make the mass percent of PLLA, PGA, chitosan be respectively 25%, 50% and 23%.Get above-mentioned mixed yarn 24 bundles, on the 3 D weaving machine, make the column-braid shape three-dimensional braid that diameter is 2mm by 3 * 8 patterns.The tension stress of this fabric is 380N, and degradation speed is 2～August.
Embodiment 2:
Get above-mentioned melt-spun PLLA fiber a little (diameter is 0.1mm), and to get PGA fiber and the diameter that an amount of diameter is 0.02mm be the chitin fiber of 0.01mm, it is long all to be cut into 500mm.PLLA, PGA and each 2,120 and 120 of the chitin fibers got respectively after the sanction are formed yarns, make the mass percent of PLLA, PGA, chitosan be respectively 21%, 65% and 14%.Get above-mentioned mixed yarn 18 bundles, on the 3 D weaving machine, make the column-braid shape three-dimensional braid that diameter is 2mm by 3 * 6 patterns.The tension stress of this fabric is 360N, and degradation speed is 2～August.
Embodiment 3:
Getting an amount of diameter is that the PLLA fiber of 0.1mm, PGA fiber and the diameter that diameter is 0.02mm are the chitin fiber of 0.01mm, and gets an amount of PLLA doughnut, all is cut into 500mm length.Each 1,1,80 and 160 of PLLA general fibre, PLLA doughnut, PGA and chitin fibers getting respectively after the sanction are formed yarns, make the mass percent of PLLA general fibre, PLLA doughnut, PGA and chitosan be respectively 12%, 12%, 51% and 23%.Get above-mentioned mixed yarn 24 bundles, on the 3 D weaving machine, make the column-braid shape three-dimensional braid that diameter is 2mm by 3 * 8 patterns.The tension stress of this fabric is 310N, and degradation speed is 2～August.
Embodiment 4:
Getting an amount of diameter is that the PLLA fiber of 0.1mm, PGA fiber and the diameter that diameter is 0.02mm are the chitin fiber of 0.01mm, and gets an amount of PLLA C fiber type, all is cut into 500mm length.Each 1,1,120 and 120 of PLLA general fibre, PLLA C fiber type, PGA and chitin fibers getting respectively after the sanction are formed yarns, make the mass percent of PLLA general fibre, PLLA C fiber type, PGA and chitosan be respectively 10%, 10%, 66% and 14%.Get above-mentioned mixed yarn 24 bundles, on the 3 D weaving machine, make the column-braid shape three-dimensional braid that diameter is 2mm by 3 * 6 patterns.The tension stress of this fabric is 290N, and degradation speed is 2～August.
Claims (1)
1. the preparation method of a multi-component hybridized 3 D woven myotendinous rack material, this method is mainly with poly-Acetic acid, hydroxy-, bimol. cyclic ester, it is material that polylactide or they respectively contain a certain proportion of copolymer aliphatic poly ester fiber, be woven into column-braid shape rope form 3 D weaving tendon stent material with circular 3 D weaving method of 1 * 1 four step, it is characterized in that: the fiber that also comprises chitosan or chitin or gelatin in the fiber, their mass percent is 0～30%, the cross section of aliphatic poly ester fiber is a typical circular, or be the heterotypic fibre of hollow circular ring shape and " C " font opening, wherein the shared mass percent of heterotypic fibre is 0～20%.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB021254680A CN1194774C (en) | 2002-08-12 | 2002-08-12 | Prepn process of multi-component hybridized 3D woven myotendinous rack material |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB021254680A CN1194774C (en) | 2002-08-12 | 2002-08-12 | Prepn process of multi-component hybridized 3D woven myotendinous rack material |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1398643A true CN1398643A (en) | 2003-02-26 |
| CN1194774C CN1194774C (en) | 2005-03-30 |
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| Application Number | Title | Priority Date | Filing Date |
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| CNB021254680A Expired - Fee Related CN1194774C (en) | 2002-08-12 | 2002-08-12 | Prepn process of multi-component hybridized 3D woven myotendinous rack material |
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Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN100372578C (en) * | 2005-05-24 | 2008-03-05 | 北京奥精医药科技有限公司 | Composite support material, composite support, and its production process |
| CN100400115C (en) * | 2005-05-24 | 2008-07-09 | 北京奥精医药科技有限公司 | Composite stent material, composite stent and production method thereof |
| CN100462108C (en) * | 2005-12-05 | 2009-02-18 | 上海天清生物材料有限公司 | Absorbable periodontal regenerative sheet and its preparing method |
| CN101732760A (en) * | 2009-12-31 | 2010-06-16 | 扬州大学 | Chitosan non-vessel stent and preparation method thereof |
| CN102499995A (en) * | 2011-12-29 | 2012-06-20 | 北京航空航天大学 | Chitin fiber reinforced polylactic acid three-dimensional porous support material and preparation method |
| CN103445884A (en) * | 2013-07-17 | 2013-12-18 | 绍兴县易比纺织科技有限公司 | Intelligent tendon repair apparatus with function of bidirectional shape memory and production method thereof |
| CN114949353A (en) * | 2022-01-24 | 2022-08-30 | 东华大学 | Biological function differentiated adaptation musculoskeletal system prosthesis and preparation method thereof |
-
2002
- 2002-08-12 CN CNB021254680A patent/CN1194774C/en not_active Expired - Fee Related
Cited By (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN100372578C (en) * | 2005-05-24 | 2008-03-05 | 北京奥精医药科技有限公司 | Composite support material, composite support, and its production process |
| CN100400115C (en) * | 2005-05-24 | 2008-07-09 | 北京奥精医药科技有限公司 | Composite stent material, composite stent and production method thereof |
| CN100462108C (en) * | 2005-12-05 | 2009-02-18 | 上海天清生物材料有限公司 | Absorbable periodontal regenerative sheet and its preparing method |
| CN101732760A (en) * | 2009-12-31 | 2010-06-16 | 扬州大学 | Chitosan non-vessel stent and preparation method thereof |
| CN102499995A (en) * | 2011-12-29 | 2012-06-20 | 北京航空航天大学 | Chitin fiber reinforced polylactic acid three-dimensional porous support material and preparation method |
| CN103445884A (en) * | 2013-07-17 | 2013-12-18 | 绍兴县易比纺织科技有限公司 | Intelligent tendon repair apparatus with function of bidirectional shape memory and production method thereof |
| CN103445884B (en) * | 2013-07-17 | 2018-07-31 | 绍兴易比纺织科技有限公司 | A kind of intelligent tendon repair device with bidirectional shape memory function |
| CN114949353A (en) * | 2022-01-24 | 2022-08-30 | 东华大学 | Biological function differentiated adaptation musculoskeletal system prosthesis and preparation method thereof |
| CN114949353B (en) * | 2022-01-24 | 2023-05-30 | 东华大学 | Biological function differentiated adaptive musculoskeletal system prosthesis and preparation method thereof |
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| Publication number | Publication date |
|---|---|
| CN1194774C (en) | 2005-03-30 |
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