CN105420848B - Superfine polyglycolide fiber, preparation method and device thereof, application thereof and patch - Google Patents
Superfine polyglycolide fiber, preparation method and device thereof, application thereof and patch Download PDFInfo
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Abstract
The invention discloses superfine polyglycolide fiber, a preparation method and a device thereof, application and a patch, belonging to the technical field of biological patch materials. The diameter of the superfine polyglycolide fiber ranges from 5 mu m to 15 mu m, and the strength ranges from 3.0cN/dtex to 7.0 cN/dtex. The preparation method and the preparation device are both used for preparing the superfine polyglycolide fiber. The superfine polyglycolide fiber can be used for a patch. The material used for preparing the patch is the superfine polyglycolide fiber. The superfine polyglycolide fiber prepared by the preparation method and the preparation device has small diameter and high strength, and can be used for manufacturing light and thin absorbable patches. The gram weight of the patch can be controlled to be 8-20 g/m2And the foreign body implantation amount is reduced to a greater extent, the patch has high softness, the pain of a patient can be relieved, and the requirements of the patient are met.
Description
Technical Field
The invention relates to the technical field of biological patch materials, in particular to superfine polyglycolide fibers, a preparation method and a device thereof, application thereof and a patch.
Background
The regenerative biological patch is extracted from natural organisms by a series of advanced technologies such as cross-linking fixation, multi-azimuth antigen removal and the like, can be understood as a 'cell scaffold', can play a good role of scaffold after being implanted into a human body according to regenerative medicine principles, molecular biology principles and immunology principles, fills up the missing tissues of the damaged part, and can gradually grow new tissues in the original position by the self-repairing function of the human body under the induction of the material to replace biological materials so as to complete the process of organ tissue regeneration. The early-stage medical dressing is mainly applied to neurosurgery, endocranial repair, esophagus cancer repair after resection, skin and pleura repair after incision of a conjoined baby, skull repair, gynecology, andrology, lung cancer, tumor and the like, and also can be used for rescuing patients with large-area burn, and the application in the field of plastic cosmetology is researched.
In the end of the 50 s, the technology of hernia repair using organic polymer materials began to be applied clinically. In recent years, with the development of technology, the material of the patch is required to be lighter, and the lighter patch has more comfortable feeling for patients and better compliance on the premise of maintaining enough tensile strength. The study of absorbable patches is now also an important direction of development.
At present, the spinning research aiming at the absorbable superfine fiber is mainly carried out on several aspects of electrostatic spinning, and the corresponding medical product development also adopts the electrostatic spinning technology to achieve the purpose of thinness. For example:
the Chinese patent with publication number CN 1687494A discloses a method for preparing a carmustine biodegradable macromolecule superfine fiber preparation, namely dissolving carmustine in a biodegradable macromolecule solution, and performing electrostatic spinning to form an ultra-long fiber non-woven fabric or fiber felt wrapped with carmustine, wherein the diameter of drug-loaded fibers can be controlled to be 0.2-2 μm.
The Chinese patent with application publication number CN 103173931A discloses a biocompatible fiber composite non-woven fabric, a preparation method and application thereof, and a preparation method of the fiber composite non-woven fabric by adopting an electrostatic spinning process.
The Chinese patent with application publication number CN 103611197A discloses a preparation method of a guided bone regeneration membrane based on hydroxyapatite grafted polylactide/polylactic acid copolymerized glycolic acid electrospun nanofiber.
The application publication number CN 103541040A of the present invention discloses a preparation method of polylactic acid superfine fiber and polylactic acid superfine fiber, wherein 30-60% of fiber grade polylactic acid and 70-40% of polyolefin resin are prepared into blended sea-island fiber, and then the blended sea-island fiber is treated by organic solvent to obtain the polylactic acid superfine fiber.
The application publication number CN 101864611A of Chinese invention discloses a polylactic acid micro-nanofiber and a preparation method thereof, polylactic acid and water-soluble resin are blended and melt-spun to obtain blended fibers, then water-soluble polyester is removed at a certain temperature by using solvent water, and the method uses an environment-friendly solvent, but the solvent water can also influence the degradation of the polylactic acid fibers.
However, none of the above solutions can satisfy the technical requirements for a lightweight absorbable patch.
Disclosure of Invention
In view of the above, the invention provides an ultrafine polyglycolide fiber, a preparation method and device thereof, an application thereof, and a patch, wherein the ultrafine polyglycolide fiber fully utilizes the characteristics of the polyethylene resin, adopts a proper spinning drafting and post-treatment process, has small fineness and high strength, and can meet the technical requirements of a lightweight absorbable patch.
In order to achieve the first object, the present invention provides the following technical solutions:
the diameter of the superfine polyglycolide fiber provided by the invention ranges from 5 mu m to 15 mu m, and the strength of the superfine polyglycolide fiber ranges from 3.0cN/dtex to 7.0 cN/dtex.
In order to achieve the second object, the preparation method of the superfine polyglycolide fiber provided by the invention mainly provides the following technical scheme:
the preparation method of the superfine polyglycolide fiber provided by the invention comprises the following steps:
respectively extruding the polyglycolide resin and the second component to obtain primary raw silk;
drafting and shaping the primary raw silk to obtain a first intermediate product;
carrying out post-treatment on the first intermediate product to obtain a second intermediate product;
and washing the second intermediate product to obtain the superfine polyglycolide fiber.
The preparation method of the superfine polyglycolide fiber provided by the invention can be further realized by adopting the following technical measures.
Preferably, the relative viscosity of the polyglycolide is in the range of 1.0dl/g to 2.0 dl/g.
Preferably, the second component is selected from one of polylactic acid, PGLA370, PGLA280, PDO, PCL.
Preferably, the mass ratio of the polyglycolide resin to the second component resin ranges from (10: 90) to (90: 10).
Preferably, the draft ratio ranges from 3.0 times to 6.0 times when the spun yarn is subjected to draft setting.
Preferably, the draft ratio is in the range of 4.5 to 5.5 times when the spun yarn is subjected to draft setting.
Preferably, when the primary yarn is drafted and shaped, the shaping temperature ranges from 100 ℃ to 130 ℃.
Preferably, when the primary yarn is drafted and shaped, the shaping temperature ranges from 115 ℃ to 125 ℃.
Preferably, when the primary yarn is subjected to drafting setting, the setting time is within the range of 1-3 h.
Preferably, the first intermediate product is worked up to give the second intermediate product by a method selected from the group consisting of:
warp knitting is carried out to obtain a warp knitted fabric, or,
weft-knitted to form a weft-knitted fabric, or,
the composite short fiber is made by curling and cutting, and then the non-woven fabric is made by the composite short fiber by water jet or needle punching.
Preferably, the method for washing the second intermediate product is ultrasonic soaking washing.
Preferably, the ultrasonic soaking and washing duration time ranges from 2h to 5 h.
Preferably, the solvent used to wash the second intermediate is a solvent that does not dissolve the polyglycolide resin.
Preferably, the solvent used for washing the second intermediate product is selected from one of acetone, DMAC, N-methylpyrrolidone, and dichloromethane.
Preferably, the extruding the polyglycolide resin and the second component to obtain the primary yarn respectively comprises the following steps:
preparing the polyglycolide resin into a homogeneous first melt;
preparing the second component into a homogeneous second melt;
metering the first melt and the second melt, and extruding to form a composite melt trickle;
and cooling the composite melt trickle to obtain the primary raw silk.
Preferably, when the composite melt trickle is cooled, the temperature of the cooling air ranges from 20 ℃ to 30 ℃.
Preferably, when the composite melt trickle is cooled, the value range of the humidity of the cooling air is 20-30%.
Preferably, when the composite melt trickle is cooled, the blowing speed of the cooling air ranges from 0.4m/s to 1 m/s.
In order to achieve the third object, the preparation device of the superfine polyglycolide fiber provided by the invention mainly provides the following technical scheme:
the device for preparing the superfine polyglycolide fiber comprises a nascent fiber preparation device, a drafting and setting device, a fabric weaving device and a washing device,
the raw silk preparation device is used for respectively extruding polyglycolide resin and a second component to obtain the raw silk;
the drafting and shaping device is used for drafting and shaping the nascent fiber to obtain a first intermediate product;
the fabric weaving device is used for carrying out post-treatment on the first intermediate product to obtain a second intermediate product;
and the washing device is used for washing the second intermediate product to obtain the superfine polyglycolide fiber.
The preparation device of the superfine polyglycolide fiber provided by the invention can be further realized by adopting the following technical measures.
Preferably, the raw silk preparation device comprises a first screw extruder, a second screw extruder, a metering device, a first conveying pipeline, a second conveying pipeline, an extrusion template and a cooling device,
the first screw extruder is used for preparing the polyglycolide resin into a uniform first melt;
the second screw extruder is used for preparing the second component into a uniform second melt;
the metering device is used for metering the first melt and the second melt;
the first conveying pipeline is used for conveying the first melt to an outlet of the extrusion template surface;
the second conveying pipeline is used for conveying the second melt to the outlet of the extrusion template surface;
the extrusion template is used for compositely extruding the first melt and the second melt from the plate surface outlet of the extrusion template to form a composite melt trickle;
the cooling device is used for cooling the composite melt trickle.
Preferably, the metering device comprises a first metering device and a second metering device,
the first metering device is used for metering the first melt;
the second metering device is used for metering the second melt.
Preferably, the first metering device is a first metering pump, and the second metering device is a second metering pump.
Preferably, the extrusion die plate is provided with a first melt extrusion micropore and a second melt extrusion micropore.
Preferably, the number of the first melt-extrusion micro-holes is at least 2, and the second melt-extrusion micro-holes are arranged between the first melt-extrusion micro-holes.
Preferably, the cooling device is a cooling air generating device.
Preferably, the cooling air generating device is provided with a temperature setting module, a humidity setting module and an air blowing speed setting module,
the temperature setting module is used for setting the temperature of cooling air;
the humidity setting module is used for setting the humidity of the cooling air;
the blowing speed setting module is used for setting the blowing speed.
Preferably, the device for preparing the superfine polyglycolide fiber further comprises an intelligent terminal, a signal setting module is arranged on the intelligent terminal,
the temperature setting module is provided with a first remote interface,
the humidity setting module is provided with a second remote interface,
the blowing speed setting module is provided with a third remote interface,
the intelligent terminal can set the temperature, the humidity and the blowing speed of the cooling air respectively through the signal setting module, the first remote interface, the second remote interface and the third remote interface.
Preferably, the signal setting module is an APP.
Preferably, the shape of the first melt-extruded microcells is selected from one or more of a circle, an ellipse, a sector, a quincunx, and a polygon.
In order to achieve the fourth object, the application of the superfine polyglycolide fiber provided by the present invention mainly provides the following technical solutions:
the invention provides application of superfine polyglycolide fiber in a patch.
The application of the superfine polyglycolide fiber provided by the invention can be further realized by adopting the following technical measures.
Preferably, the patch is a thin, lightweight absorbable patch.
In order to achieve the fifth object, the patch provided by the invention mainly provides the following technical scheme:
in the patch provided by the invention, the material for preparing the patch comprises the superfine polyglycolide fiber provided by the invention.
The superfine polyglycolide fiber prepared by the preparation method and the preparation device provided by the invention has small diameter and high strength, and can be used for manufacturing light and thin absorbable patches. The gram weight of the patch can be controlled to be 8-20 g/m2Left and right, and decrease to a greater extentThe foreign body implantation amount is reduced, the softness of the patch is high, the pain of a patient can be relieved, and the requirement of the patient is met.
Detailed Description
The invention provides superfine glycolide fibers, a preparation method, a preparation device, application and patches thereof, which aim to solve the problems in the prior art.
To further illustrate the technical means and effects of the present invention adopted to achieve the predetermined objects, the following detailed description, in conjunction with the preferred embodiments, will be made on the superfine glycolide fibers, the preparation method, the preparation device, the use and the patch thereof according to the present invention, the detailed description, the structure, the characteristics and the effects thereof. In the following description, different "one embodiment" or "an embodiment" refers to not necessarily the same embodiment. Furthermore, the particular features, structures, or characteristics may be combined in any suitable manner in one or more embodiments.
The term "and/or" herein is merely an association describing an associated object, meaning that three relationships may exist, e.g., a and/or B, with the specific understanding that: both a and B may be included, a may be present alone, or B may be present alone, and any of the three cases can be provided.
The technical parameters are selected and are detailed in the implementation and comparative examples in the table.
The diameter of the superfine polyglycolide fiber provided by the embodiment of the invention ranges from 5 mu m to 15 mu m, and the strength of the superfine polyglycolide fiber ranges from 3.0cN/dtex to 7.0 cN/dtex.
The preparation method of the superfine polyglycolide fiber provided by the embodiment of the invention comprises the following steps:
step 1: respectively extruding the polyglycolide resin and the second component to obtain primary raw silk;
step 2: drafting and shaping the primary yarn to obtain a first intermediate product;
and step 3: carrying out post-treatment on the first intermediate product to obtain a second intermediate product;
and 4, step 4: and washing the second intermediate product to obtain the superfine polyglycolide fiber.
Wherein the relative viscosity of the polyglycolide can be 1.0dl/g to 2.0 dl/g.
Wherein, the second component can be one selected from polylactic acid, PGLA370, PGLA280, PDO and PCL.
Wherein, the mass ratio of the polyglycolide resin to the second component resin can be (10: 90) to (90: 10).
When the primary yarn is drafted and shaped, the value range of the draft multiple can be 3.0-6.0 times.
Wherein, when the primary yarn is drafted and shaped, the value range of the drafting multiple can be 4.5 times to 5.5 times.
Wherein, when the primary yarn is drafted and shaped, the shaping temperature can be 100-130 ℃.
Wherein, when the primary yarn is drafted and shaped, the shaping temperature can be 115-125 ℃.
When the primary yarn is drafted and shaped, the value range of the shaping time can be 1-3 h.
Wherein, the method for post-treating the first intermediate product to obtain the second intermediate product can be selected from: the warp knitting is made into warp knitting fabric, or the weft knitting is made into weft knitting fabric, or the warp knitting fabric is curled and cut into composite short fibers, and then the composite short fibers are spun-laced or needle-punched to prepare the non-woven fabric.
Wherein, the method for washing the second intermediate product can be ultrasonic soaking washing.
Wherein the ultrasonic soaking and washing duration time can be 2-5 h.
The solvent used for washing the second intermediate product may be a solvent that does not dissolve the polyglycolide resin.
Wherein, the solvent used for washing the second intermediate product can be one selected from acetone, DMAC, N-methylpyrrolidone and dichloromethane.
Wherein, extruding the polyglycolide resin and the second component respectively to obtain the nascent fiber can comprise the following steps:
step 11: preparing polyglycolide resin into a uniform first melt;
step 12: preparing the second component into a uniform second melt;
step 13: metering the first melt and the second melt, and extruding to form a composite melt trickle;
step 14: and cooling the composite melt trickle to obtain the primary raw silk.
Wherein, when the composite melt trickle is cooled, the value range of the temperature of the cooling air can be 20-30 ℃.
Wherein, when the composite melt trickle is cooled, the value range of the humidity of the cooling air can be 20-30%.
When the composite melt trickle is cooled, the blowing speed of cooling air can be 0.4-1 m/s.
The preparation device of the superfine polyglycolide fiber provided by the embodiment of the invention comprises a nascent fiber preparation device, a drafting and setting device, a fabric weaving device and a washing device, wherein the nascent fiber preparation device is used for respectively extruding polyglycolide resin and a second component to obtain nascent fiber; the drafting and shaping device is used for drafting and shaping the nascent fiber to obtain a first intermediate product; the fabric weaving device is used for carrying out post-treatment on the first intermediate product to obtain a second intermediate product; and the washing device is used for washing the second intermediate product to obtain the superfine polyglycolide fiber.
As a specific implementation manner of the raw silk preparation device, the raw silk preparation device may include a first screw extruder, a second screw extruder, a metering device, a first conveying pipeline, a second conveying pipeline, an extrusion template, and a cooling device, wherein the first screw extruder is used for preparing polyglycolide resin into a uniform first melt; the second screw extruder is used for preparing the second component into a uniform second melt; the metering device is used for metering the first melt and the second melt; the first conveying pipeline is used for conveying the first melt to an outlet of the surface of the extrusion template; the second conveying pipeline is used for conveying the second melt to an outlet of the surface of the extrusion template; the extrusion template is used for compositely extruding the first melt and the second melt from an outlet of the surface of the extrusion template to form a composite melt trickle; the cooling device is used for cooling the composite melt trickle.
The metering device can comprise a first metering device and a second metering device, wherein the first metering device is used for metering the first melt; the second metering device is used for metering the second melt. In this case, the first melt and the second melt have respective metering devices, so that the metering accuracy can be increased without mutual interference.
As a specific implementation manner of the first metering device and the second metering device, the first metering device may be a first metering pump, and the second metering device is a second metering pump.
As a specific implementation manner of the extrusion template, the extrusion template may be provided with a first melt extrusion micro-hole and a second melt extrusion micro-hole. In this case, the first melt and the second melt are extruded from the respective cells, and then mixed.
Wherein, the number of the first melt extrusion micropores can be at least 2, and the second melt extrusion micropores are arranged between the first melt extrusion micropores.
Wherein, the cooling device can be a cooling wind generating device.
The cooling air generating device can be provided with a temperature setting module, a humidity setting module and a blowing speed setting module, wherein the temperature setting module is used for setting the temperature of cooling air; the humidity setting module is used for setting the humidity of the cooling air; the blowing speed setting module is used for setting the blowing speed. In this case, the setting of the relevant parameters of the cooling air can be realized by operating the temperature setting module, the humidity setting module, the blowing speed setting module, and the temperature setting module, thereby saving human resources, which is disadvantageous in that an operator must watch around the cooling air generating apparatus.
Wherein, this superfine polyglycolide fibrous preparation facilities can also include intelligent terminal, the last signal that is equipped with of intelligent terminal sets up the module, be equipped with first remote interface on the temperature setting module, be equipped with the remote interface of second on the humidity setting module, be equipped with the remote interface of third on the blast speed setting module, intelligent terminal passes through signal setting module, first remote interface, the remote interface of second, the remote interface of third can be set for the temperature, humidity, the blast speed of cooling air respectively. In this case, the operator can set the relevant parameter of the cooling air by operating the intelligent terminal without being in the vicinity of the cooling air generator.
The signal setting module may be an APP. Because APP can freely load on only the terminal such as a mobile phone, the installation is simple, and the operation is convenient.
Wherein the shape of the first melt-extruded microcells may be selected from one or more of a circle, an ellipse, a sector, a quincunx, and a polygon.
The superfine polyglycolide fiber provided by the embodiment of the invention can be used for the purpose of a patch.
The patch made of the superfine polyglycolide fibers provided by the embodiment of the invention is a light and thin absorbable patch.
The material for manufacturing the patch provided by the embodiment of the invention comprises the superfine polyglycolide fiber provided by the embodiment of the invention.
Examples and comparative examples
Continuation table
From the above examples 1 to 22 and comparative examples 1 to 5, it can be seen that the diameter of the ultrafine polyglycolide fiber prepared by the preparation method and the preparation apparatus provided by the embodiments of the present invention ranges from 5 μm to 15 μm, and the strength of the ultrafine polyglycolide fiber ranges from 3.0cN/dtex to 7.0 cN/dtex. Further used to make thin, lightweight absorbable patches. The gram weight of the patch can be controlled to be 8-20 g/m2And the foreign body implantation amount is reduced to a greater extent, the patch has high softness, the pain of a patient can be relieved, and the requirements of the patient are met. The diameter of the polyglycolide fiber prepared by the comparative example ranges from 3 mu m to 17 mu m, the strength ranges from 1.4cN/dtex to 2.7cN/dtex, wherein the patches cannot be prepared by the comparative example 1 and the comparative example 5, and the gram weight of the prepared patches is 25 to 35g/m although the patches can be prepared by the comparative examples 2 to 42The implantation amount of the foreign matters is larger than that of the patch provided by the embodiment of the invention, and the effect is not as good as that of the patch provided by the embodiment of the invention.
While preferred embodiments of the present invention have been described, additional variations and modifications in those embodiments may occur to those skilled in the art once they learn of the basic inventive concepts. Therefore, it is intended that the appended claims be interpreted as including preferred embodiments and all such alterations and modifications as fall within the scope of the invention.
It will be apparent to those skilled in the art that various changes and modifications may be made in the present invention without departing from the spirit and scope of the invention. Thus, if such modifications and variations of the present invention fall within the scope of the claims of the present invention and their equivalents, the present invention is intended to include such modifications and variations.
Claims (28)
1. A patch is characterized in that the patch is made of superfine polyglycolide fiber, the diameter of the superfine polyglycolide fiber ranges from 5 mu m to 15 mu m, the strength of the superfine polyglycolide fiber ranges from 3.0cN/dtex to 7.0cN/dtex,
the preparation method of the superfine polyglycolide fiber comprises the following steps:
respectively extruding the polyglycolide resin and the second component to obtain primary raw silk;
drafting and shaping the primary raw silk to obtain a first intermediate product;
carrying out post-treatment on the first intermediate product to obtain a second intermediate product;
washing the second intermediate product to obtain the superfine polyglycolide fiber;
the gram weight of the patch is controlled to be 8-20 g/m2；
The first intermediate product is post-treated to obtain a second intermediate product by a method selected from the group consisting of:
warp knitting is carried out to obtain a warp knitted fabric, or,
weft-knitted to form a weft-knitted fabric, or,
the composite short fiber is made by curling and cutting, and then the non-woven fabric is made by the composite short fiber by water jet or needle punching.
2. A patch according to claim 1, wherein the polyglycolide has a relative viscosity ranging from 1.0dl/g to 2.0 dl/g.
3. The patch of claim 1, wherein the second component is selected from one of polylactic acid, PGLA370, PGLA280, PDO, PCL.
4. A patch according to claim 1, wherein the mass ratio of polyglycolide resin to the second component resin is in the range of (10: 90) to (90: 10).
5. The patch of claim 1, wherein the draft ratio ranges from 3.0 times to 6.0 times when the raw silk is drafted and set.
6. The patch of claim 5, wherein the draft ratio ranges from 4.5 times to 5.5 times when the raw silk is drafted and sized.
7. The patch of claim 1, wherein the setting temperature ranges from 100 ℃ to 130 ℃ when the as-spun yarn is subjected to drawing setting.
8. A patch according to claim 7, wherein the setting temperature is in the range of 115 ℃ to 125 ℃ when the as-spun yarn is subjected to drawing setting.
9. The patch of claim 1, wherein the setting time ranges from 1 to 3 hours when the raw silk is subjected to drafting setting.
10. A patch according to claim 1, characterized in that the method of washing the second intermediate product is an ultrasonic soak wash.
11. The patch according to claim 10, wherein the ultrasonic soaking washing duration ranges from 2h to 5 h.
12. A patch according to claim 1, wherein the solvent used in washing the second intermediate product is a solvent that does not dissolve the polyglycolide resin.
13. A patch according to claim 12, wherein the solvent used for washing the second intermediate product is selected from one of acetone, DMAC, N-methylpyrrolidone, dichloromethane.
14. A patch according to claim 12, wherein said extruding polyglycolide resin separately from the second component to provide as-spun filaments comprises the steps of:
preparing the polyglycolide resin into a homogeneous first melt;
preparing the second component into a homogeneous second melt;
metering the first melt and the second melt, and extruding to form a composite melt trickle;
and cooling the composite melt trickle to obtain the primary raw silk.
15. A patch according to claim 14, wherein the temperature of the cooling air is in the range of 20 ℃ to 30 ℃ when the composite melt trickle is cooled.
16. The patch of claim 14, wherein the humidity of the cooling air ranges from 20% to 30% when the composite melt trickle is cooled.
17. A patch according to claim 14, wherein the blowing speed of the cooling air is in the range of 0.4m/s to 1m/s when the composite melt trickle is cooled.
18. A patch according to claim 1, wherein the preparation device of said superfine polyglycolide fiber comprises a primary yarn preparation device, a drafting and shaping device, a fabric weaving device, a washing device,
the raw silk preparation device is used for respectively extruding polyglycolide resin and a second component to obtain the raw silk;
the drafting and shaping device is used for drafting and shaping the nascent fiber to obtain a first intermediate product;
the fabric weaving device is used for carrying out post-treatment on the first intermediate product to obtain a second intermediate product;
and the washing device is used for washing the second intermediate product to obtain the superfine polyglycolide fiber.
19. The patch of claim 18, wherein the as-spun yarn preparation device comprises a first screw extruder, a second screw extruder, a metering device, a first conveying line, a second conveying line, an extrusion die plate, a cooling device,
the first screw extruder is used for preparing the polyglycolide resin into a uniform first melt;
the second screw extruder is used for preparing the second component into a uniform second melt;
the metering device is used for metering the first melt and the second melt;
the first conveying pipeline is used for conveying the first melt to an outlet of the extrusion template surface;
the second conveying pipeline is used for conveying the second melt to the outlet of the extrusion template surface;
the extrusion template is used for compositely extruding the first melt and the second melt from the plate surface outlet of the extrusion template to form a composite melt trickle;
the cooling device is used for cooling the composite melt trickle.
20. A patch according to claim 19, wherein the metering device comprises a first metering device, a second metering device,
the first metering device is used for metering the first melt;
the second metering device is used for metering the second melt.
21. The patch of claim 20, wherein the first metering device is a first metering pump and the second metering device is a second metering pump.
22. A patch according to claim 19, wherein the extrusion die plate is provided with first and second melt-extruded apertures.
23. A patch according to claim 22, wherein the first melt-extruded micro-apertures are at least 2 and the second melt-extruded micro-apertures are disposed between the first melt-extruded micro-apertures.
24. A patch according to claim 19, wherein the cooling means is a cooling wind generating means.
25. A patch according to claim 24, wherein the cooling wind generating device is provided with a temperature setting module, a humidity setting module and a blowing speed setting module,
the temperature setting module is used for setting the temperature of cooling air;
the humidity setting module is used for setting the humidity of the cooling air;
the blowing speed setting module is used for setting the blowing speed.
26. A patch according to claim 25, further comprising an intelligent terminal, said intelligent terminal having a signal setting module thereon,
the temperature setting module is provided with a first remote interface,
the humidity setting module is provided with a second remote interface,
the blowing speed setting module is provided with a third remote interface,
the intelligent terminal can set the temperature, the humidity and the blowing speed of the cooling air respectively through the signal setting module, the first remote interface, the second remote interface and the third remote interface.
27. A patch according to claim 26, wherein said signal setting module is an APP.
28. A patch according to claim 22, wherein the shape of the first melt-extruded micro-holes is selected from one or more of circular, oval, fan-shaped, quincunx, polygonal.
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| CN111905149A (en) * | 2020-07-30 | 2020-11-10 | 中国纺织科学研究院有限公司 | Anti-sticking partially absorbable tissue repair material and preparation method thereof |
| CN112915256B (en) * | 2021-01-11 | 2022-09-16 | 华南理工大学 | Method for preparing human dura mater repair material with imitated ECM (extracellular matrix) components and structure by long fiber network framework preforming method |
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