CN105420848A - Superfine polyglycollide fiber and preparation method and device, application and patch thereof - Google Patents
Superfine polyglycollide fiber and preparation method and device, application and patch thereof Download PDFInfo
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Abstract
The invention discloses a superfine polyglycollide fiber and a preparation method and device, application and a patch thereof, and belongs to the technical field of biological patch materials. The diameter of the superfine polyglycollide fiber ranges from 5 micrometers to 15 micrometers, and the strength of the superfine polyglycollide fiber ranges from 3.0 cN/dtex to 7.0 cN/dtex. The preparation method and device are both used for preparing the superfine polyglycollide fiber. The superfine polyglycollide fiber can be applied to the patch. The patch is made of the superfine polyglycollide fiber. The superfine polyglycollide fiber prepared through the preparation method and device is small in diameter and high in strength and can be used for manufacturing the light and thin absorbable patch. The gram weight of the patch can be controlled within 8-20 g/m<2>, the foreign matter implant amount is decreased to the greater extent, the flexibility of the patch is high, the pain of a patient can be reduced better, and the requirements of the patient are met.
Description
Technical field
The present invention relates to biological sticking patch material technical field, particularly relate to a kind of ultra-fine polyglycollide fibre, its preparation method and device, purposes, sticking patch.
Background technology
Regenerative biological sticking patch is extracted from natural biology by the crosslinked fixing of advanced person and multi-faceted a series of technology such as antigen of removing, can be understood to " cytoskeleton ", it is according to after regenerative medicine principle, molecular biology principle and immunology principle implant into body, good support effect can be played, fill up the missing tissues of damaged part, and under the induction of this material, human body self repair function can grow in original position the tissue made new advances gradually, replace biomaterial, complete the process of organ regeneration.Mainly apply to neurosurgery, the reparation of endomeninx in early days, repairing, siamese twins cut rear skin, pleura reparation, skull reparation, gynaecology, andrology, lung cancer, tumour etc. afterwards in cancer of the esophagus excision, also have Emergency Treatment of Extensive Burn patient, and start now to probe into the use in shaping and beauty field.
At the end of the fifties, the technology utilizing high-molecular organic material to carry out hernia benefit starts to be applied to clinical.In recent years along with the development of technology, the material of sticking patch requires lightweight more, and under the prerequisite keeping enough tension stress intensity, lighter sticking patch has more comfortable patient's sensation and better compliance.The research of present Absorbable rod sticking patch is also important developing direction.
Spinning research at present for Absorbable rod superfine fibre is mainly several in electrostatic spinning, and corresponding medical product exploitation is also adopt electrostatic spinning technique to reach carefully thin object.Such as:
Publication number is the preparation method that the Chinese invention patent of CN1687494A discloses a kind of carmustinum Biodegradable high-molecular superfine fibre formulation, be dissolved in biodegradable polymeric solution by carmustinum, carry out electrostatic spinning, form the super Fine fabric nonwoven cloth or the fibrofelt that are enclosed with carmustinum, drug-loading fibre diameter can control at 0.2 ~ 2 μm.
Application publication number is that the Chinese invention patent of CN103173931A discloses a kind of biocompatible fiber composite nonwoven fabric and its preparation method and application, the preparation method of the fiber composite nonwoven fabric adopting electrostatic spinning process to carry out.
Application publication number is the preparation that the Chinese invention patent of CN103611197A discloses a kind of Guided Bone Regeneration film based on hydroxyapatite grafting polylactide/PLA copolymerization glycolic acid electrostatic spinning nano fiber.
Application publication number is preparation method and the PLA superfine fibre that the Chinese invention patent of CN103541040A discloses a kind of PLA superfine fibre, the fibre-grade PLA of 30 ~ 60% and 70% ~ 40% vistanex are prepared alloying island fibre by it, then obtain PLA superfine fibre through organic solvent process.
Application publication number is that the Chinese invention patent of CN101864611A discloses a kind of polylactic acid nano fiber and preparation method thereof, it is by PLA and water-soluble resin is blended obtains blended fiber through melt spinning, then remove water-soluble polyester at a certain temperature with aqueous solvent, the solvent environmental protection that the method uses but simultaneously aqueous solvent also can affect the degraded of acid fiber by polylactic.
But technique scheme all cannot meet the technical need of lightweight Absorbable rod sticking patch.
Summary of the invention
In view of this, the invention provides a kind of ultra-fine polyglycollide fibre, its preparation method and device, purposes, sticking patch, this ultra-fine polyglycollide fibre makes full use of the feature of poly-second glue ester resin, adopt suitable spinning drawing and aftertreatment technology, fiber number is little, intensity is high, and can meet the technical need of lightweight Absorbable rod sticking patch.
In order to reach above-mentioned first object, ultra-fine polyglycollide fibre provided by the invention following technical scheme is mainly provided:
Ultra-fine polyglycollide fibre provided by the invention, the span of the diameter of described ultra-fine polyglycollide fibre is 5 μm ~ 15 μm, and the span of the intensity of described ultra-fine polyglycollide fibre is 3.0cN/dtex ~ 7.0cN/dtex.
In order to reach above-mentioned second object, the preparation method of ultra-fine polyglycollide fibre provided by the invention mainly provides following technical scheme:
The preparation method of ultra-fine polyglycollide fibre provided by the invention comprises the following steps:
PGA resin and second component are extruded respectively and obtains spun filament;
Drafting forming is carried out to described spun filament, obtains the first intermediate product;
Post processing is carried out to described first intermediate product, obtains the second intermediate product;
Described second intermediate product is washed, obtains described ultra-fine polyglycollide fibre.
The preparation method of ultra-fine polyglycollide fibre provided by the invention also can be applied to the following technical measures to achieve further.
As preferably, the span of the relative viscosity of described PGA is 1.0dl/g ~ 2.0dl/g.
As preferably, described second component is selected from the one in PLA, PGLA370, PGLA280, PDO, PCL.
As preferably, the span of the mass ratio of described PGA resin and second component resin is (10: 90) ~ (90: 10).
As preferably, when carrying out drafting forming to described spun filament, the span of drafting multiple is 3.0 times ~ 6.0 times.
As preferably, when carrying out drafting forming to described spun filament, the span of drafting multiple is 4.5 times ~ 5.5 times.
As preferably, when carrying out drafting forming to described spun filament, the span of setting temperature is 100 DEG C ~ 130 DEG C.
As preferably, when carrying out drafting forming to described spun filament, the span of setting temperature is 115 DEG C ~ 125 DEG C.
As preferably, when carrying out drafting forming to described spun filament, the span of shaping time is 1 ~ 3h.
As preferably, carry out post processing to described first intermediate product, the method obtaining the second intermediate product is selected from:
Through being compiled into tricot, or,
Weft-knitted fabric is made in weft knitting, or,
Composite short fiber is made in curling cut-out, then described composite short fiber water thorn or acupuncture is prepared into nonwoven fabric.
As preferably, the method for washing described second intermediate product is ultrasonic washing by soaking.
As preferably, the span of described ultrasonic washing by soaking duration is 2h ~ 5h.
As preferably, when washing described second intermediate product, the solvent of application is the solvent of soluble solution PGA resin.
As preferably, the one in the solvent selected from acetone of application when described second intermediate product is washed, DMAC, 1-METHYLPYRROLIDONE, carrene.
As preferably, described PGA resin and second component being extruded respectively obtains spun filament and comprises the following steps:
By standby for described PGA resin-made uniformly the first melt;
Described second component is prepared into uniform second melt;
Described first melt, the second melt are extruded after measuring, forms compounding flux thread;
Described compounding flux thread is cooled, obtains described spun filament.
As preferably, when cooling described compounding flux thread, the span of the temperature of cooling air is 20 DEG C ~ 30 DEG C.
As preferably, when cooling described compounding flux thread, the span of the humidity of cooling air is 20% ~ 30%.
As preferably, when cooling described compounding flux thread, the span of the cold air blast velocity of cooling air is 0.4m/s ~ 1m/s.
In order to reach above-mentioned 3rd object, the preparation facilities of ultra-fine polyglycollide fibre provided by the invention mainly provides following technical scheme:
The preparation facilities of ultra-fine polyglycollide fibre provided by the invention comprises spun filament preparation facilities, drafting-shaping device, weaving textile device, wash mill,
Described spun filament preparation facilities is used for PGA resin and second component to extrude respectively, obtains described spun filament;
Described drafting-shaping device is used for carrying out drafting forming to described spun filament, obtains the first intermediate product;
Described weaving textile device is used for carrying out post processing to described first intermediate product, obtains the second intermediate product;
Described wash mill is used for washing described second intermediate product, obtains described ultra-fine polyglycollide fibre.
The preparation facilities of ultra-fine polyglycollide fibre provided by the invention also can be applied to the following technical measures to achieve further.
As preferably, described spun filament preparation facilities comprises the first screw extruder, the second screw extruder, metering device, the first transfer pipeline, the second transfer pipeline, extrusion die, cooling device,
Described first screw extruder is used for standby for described PGA resin-made uniformly the first melt;
Described second screw extruder is used for described second component to be prepared into uniform second melt;
Described metering device is used for measuring described first melt, the second melt;
Described first transfer pipeline is for carrying described first melt to exit, described extrusion die plate face;
Described second transfer pipeline is for carrying described second melt to exit, described extrusion die plate face;
Described extrusion die is used for making described first melt, the second melt from exit, described extrusion die plate face compound extruded, forms compounding flux thread;
Described cooling device is used for cooling described compounding flux thread.
As preferably, described metering device comprises the first metering device, the second metering device,
Described first metering device is used for measuring described first melt;
Described second metering device is used for measuring described second melt.
As preferably, described first metering device is the first measuring pump, and described second metering device is the second measuring pump.
As preferably, described extrusion die is provided with the first melt extrusion micropore, the second melt extrusion micropore.
As preferably, described first melt extrusion micropore is at least 2, and described second melt extrusion micropore is arranged between described first melt extrusion micropore.
As preferably, described cooling device is cooling air generating means.
As preferably, described cooling air generating means is provided with temperature setting module, humidity set module, cold air blast velocity setting module,
Described temperature setting module is used for setting the temperature of cooling air;
Described humidity set module is used for setting the humidity of described cooling air;
Described cold air blast velocity setting module is used for setting described cold air blast velocity.
As preferably, the preparation facilities of described ultra-fine polyglycollide fibre also comprises intelligent terminal, and described intelligent terminal is provided with signal setting module,
Described temperature setting module is provided with the first remote interface,
Described humidity set module is provided with the second remote interface,
Described cold air blast velocity setting module is provided with the 3rd remote interface,
Described intelligent terminal can be set the temperature of described cooling air, humidity, cold air blast velocity respectively by described signal setting module, the first remote interface, the second remote interface, the 3rd remote interface.
As preferably, described signal setting module is an APP.
As preferably, one or more in the shape selected from circles of described first melt extrusion micropore, ellipse, fan-shaped, quincunx, polygon.
In order to reach above-mentioned 4th object, the purposes of ultra-fine polyglycollide fibre provided by the invention mainly provides following technical scheme:
Ultra-fine polyglycollide fibre provided by the invention is used for the purposes of sticking patch.
The purposes of ultra-fine polyglycollide fibre provided by the invention also can be applied to the following technical measures to achieve further.
As preferably, described sticking patch is light and thin type Absorbable rod sticking patch.
In order to reach above-mentioned 5th object, sticking patch provided by the invention mainly provides following technical scheme:
In sticking patch provided by the invention, the material for making described sticking patch comprises ultra-fine polyglycollide fibre provided by the invention.
Apply preparation method provided by the invention, preparation facilities prepares ultra-fine polyglycollide fibre diameter is little, intensity large, can be used for manufacturing light and thin type Absorbable rod sticking patch.This sticking patch grammes per square metre can be controlled in 8 ~ 20g/m
2left and right, decreases foreign matter implantation amount to a greater extent, and the pliability of sticking patch is large, more can alleviate the misery of patient, meet the needs of patient.
Detailed description of the invention
The present invention, for solving prior art Problems existing, provides a kind of ultra-fine according to glycolide fiber, its preparation method, preparation facilities and purposes, sticking patch.
For further setting forth the present invention for the technological means reaching predetermined goal of the invention and take and effect, below in conjunction with preferred embodiment, ultra-fine according to glycolide fiber, its preparation method, preparation facilities and purposes, sticking patch to what propose according to the present invention, its detailed description of the invention, structure, feature and effect thereof, be described in detail as follows.In the following description, the not necessarily same embodiment that different " embodiment " or " embodiment " refers to.In addition, special characteristic, structure or feature in one or more embodiment can be combined by any suitable form.
Term "and/or" herein, being only a kind of incidence relation describing affiliated partner, can there are three kinds of relations in expression, such as, A and/or B, concrete is interpreted as: can include A and B simultaneously, can individualism A, also can individualism B, above-mentioned three kinds of any one situations can be possessed.
Wherein relate to the selected of technical parameter, refer to the enforcement in form and comparative example.
The span of the diameter of the ultra-fine polyglycollide fibre that the embodiment of the present invention provides is 5 μm ~ 15 μm, and the span of the intensity of ultra-fine polyglycollide fibre is 3.0cN/dtex ~ 7.0cN/dtex.
The preparation method of the ultra-fine polyglycollide fibre that the embodiment of the present invention provides comprises the following steps:
Step 1: PGA resin and second component are extruded respectively and obtains spun filament;
Step 2: carry out drafting forming to spun filament, obtains the first intermediate product;
Step 3: carry out post processing to the first intermediate product, obtains the second intermediate product;
Step 4: wash the second intermediate product, obtains ultra-fine polyglycollide fibre.
Wherein, the span of the relative viscosity of PGA can be 1.0dl/g ~ 2.0dl/g.
Wherein, second component can be selected from the one in PLA, PGLA370, PGLA280, PDO, PCL.
Wherein, the span of the mass ratio of PGA resin and second component resin can be (10: 90) ~ (90: 10).
Wherein, when carrying out drafting forming to spun filament, the span of drafting multiple can be 3.0 times ~ 6.0 times.
Wherein, when carrying out drafting forming to spun filament, the span of drafting multiple can be 4.5 times ~ 5.5 times.
Wherein, when carrying out drafting forming to spun filament, the span of setting temperature can be 100 DEG C ~ 130 DEG C.
Wherein, when carrying out drafting forming to spun filament, the span of setting temperature can be 115 DEG C ~ 125 DEG C.
Wherein, when carrying out drafting forming to spun filament, the span of shaping time can be 1 ~ 3h.
Wherein, carry out post processing to the first intermediate product, the method obtaining the second intermediate product can be selected from: through being compiled into tricot, or weft-knitted fabric is made in weft knitting, or, composite short fiber is made in curling cut-out, then composite short fiber water thorn or acupuncture is prepared into nonwoven fabric.
Wherein, the method for washing the second intermediate product can be ultrasonic washing by soaking.
Wherein, the span of ultrasonic washing by soaking duration can be 2h ~ 5h.
Wherein, the solvent of application when washing the second intermediate product can be the solvent of soluble solution PGA resin.
Wherein, when washing the second intermediate product, the solvent of application can be selected from the one in acetone, DMAC, 1-METHYLPYRROLIDONE, carrene.
Wherein, PGA resin and second component are extruded respectively obtain spun filament and can comprise the following steps:
Step 11: by standby for PGA resin-made uniformly the first melt;
Step 12: second component is prepared into uniform second melt;
Step 13: extrude after measuring the first melt, the second melt, forms compounding flux thread;
Step 14: compounding flux thread is cooled, obtains spun filament.
Wherein, when cooling compounding flux thread, the span of the temperature of cooling air can be 20 DEG C ~ 30 DEG C.
Wherein, when cooling compounding flux thread, the span of the humidity of cooling air can be 20% ~ 30%.
Wherein, when cooling compounding flux thread, the span of the cold air blast velocity of cooling air can be 0.4m/s ~ 1m/s.
The preparation facilities of the ultra-fine polyglycollide fibre that the embodiment of the present invention provides comprises spun filament preparation facilities, drafting-shaping device, weaving textile device, wash mill, spun filament preparation facilities is used for PGA resin and second component to extrude respectively, obtains spun filament; Drafting-shaping device is used for carrying out drafting forming to spun filament, obtains the first intermediate product; Weaving textile device is used for carrying out post processing to the first intermediate product, obtains the second intermediate product; Wash mill is used for washing the second intermediate product, obtains ultra-fine polyglycollide fibre.
Wherein, as a kind of concrete implementation of spun filament preparation facilities, spun filament preparation facilities can comprise the first screw extruder, the second screw extruder, metering device, the first transfer pipeline, the second transfer pipeline, extrusion die, cooling device, and the first screw extruder is used for standby for PGA resin-made uniformly the first melt; Second screw extruder is used for second component to be prepared into uniform second melt; Metering device is used for measuring the first melt, the second melt; First transfer pipeline is for carrying the first melt to exit, extrusion die plate face; Second transfer pipeline is for carrying the second melt to exit, extrusion die plate face; Extrusion die is used for making the first melt, the second melt from exit, extrusion die plate face compound extruded, forms compounding flux thread; Cooling device is used for cooling compounding flux thread.
Wherein, metering device can comprise the first metering device, the second metering device, and the first metering device is used for measuring the first melt; Second metering device is used for measuring the second melt.In this case, the first melt, the second melt have respective metering device respectively, can increase the accuracy of metering, and be unlikely to produce interference each other.
Wherein, as a kind of concrete implementation of the first metering device and the second metering device, the first metering device can be the first measuring pump, and the second metering device is the second measuring pump.
Wherein, as a kind of concrete implementation of extrusion die, extrusion die can be provided with the first melt extrusion micropore, the second melt extrusion micropore.In this case, the first melt, the second melt can realize mixing respectively after respective micropore is extruded.
Wherein, the first melt extrusion micropore can be at least 2, and the second melt extrusion micropore is arranged between the first melt extrusion micropore.
Wherein, cooling device can be cooling air generating means.
Wherein, cooling air generating means can be provided with temperature setting module, humidity set module, cold air blast velocity setting module, temperature setting module is used for setting the temperature of cooling air; Humidity set module is used for setting the humidity of cooling air; Cold air blast velocity setting module is used for setting cold air blast velocity.In this case, can realize setting the relevant parameter of cooling air by operating temperature setting module, humidity set module, cold air blast velocity setting module, temperature setting module, thus saving human resources, its shortcoming is, operating personnel must be on duty near this cooling air generating means.
Wherein, the preparation facilities of this ultra-fine polyglycollide fibre can also comprise intelligent terminal, intelligent terminal is provided with signal setting module, temperature setting module is provided with the first remote interface, humidity set module is provided with the second remote interface, cold air blast velocity setting module is provided with the 3rd remote interface, and intelligent terminal can be set the temperature of cooling air, humidity, cold air blast velocity respectively by signal setting module, the first remote interface, the second remote interface, the 3rd remote interface.In this case, operating personnel near this cooling air generating means, but by operating intelligent terminal, can realize the action set the relevant parameter of cooling air without the need on duty.
Wherein, signal setting module can be an APP.APP can only in terminal, install simple, easy to operate owing to freely can be loaded in mobile phone etc.
Wherein, the shape of the first melt extrusion micropore can be selected from one or more in circle, ellipse, fan-shaped, quincunx, polygon.
The ultra-fine polyglycollide fibre that the embodiment of the present invention provides may be used for the purposes of sticking patch.
Wherein, the sticking patch that the ultra-fine polyglycollide fibre that the application embodiment of the present invention provides is made is light and thin type Absorbable rod sticking patch.
Material for making the sticking patch that the embodiment of the present invention provides comprises the ultra-fine polyglycollide fibre that the embodiment of the present invention provides.
Embodiment and comparative example
Continued
From above-described embodiment 1 ~ 22, comparative example 1 ~ 5, can find out, the span of the diameter of the ultra-fine polyglycollide fibre that the preparation method adopting the embodiment of the present invention to provide, preparation facilities are made is 5 μm ~ 15 μm, and the span of the intensity of ultra-fine polyglycollide fibre is 3.0cN/dtex ~ 7.0cN/dtex.Further with manufacturing light and thin type Absorbable rod sticking patch.This sticking patch grammes per square metre can be controlled in 8 ~ 20g/m
2left and right, decreases foreign matter implantation amount to a greater extent, and the pliability of sticking patch is large, more can alleviate the misery of patient, meet the needs of patient.And the span of the diameter of the polyglycollide fibre that comparative example obtains is 3 μm ~ 17 μm, the span of intensity is 1.4cN/dtex ~ 2.7cN/dtex, wherein, comparative example 1 and comparative example 5 cannot obtain sticking patch, although comparative example 2 ~ 4 can obtain sticking patch, but obtained sticking patch grammes per square metre is at 25 ~ 35g/m
2, the sticking patch that foreign matter implantation amount provides compared with the embodiment of the present invention is large, and the sticking patch that effect also provides not as the embodiment of the present invention is good.
Although describe the preferred embodiments of the present invention, those skilled in the art once obtain the basic creative concept of cicada, then can make other change and amendment to these embodiments.So claims are intended to be interpreted as comprising preferred embodiment and falling into all changes and the amendment of the scope of the invention.
Obviously, those skilled in the art can carry out various change and modification to the present invention and not depart from the spirit and scope of the present invention.Like this, if these amendments of the present invention and modification belong within the scope of the claims in the present invention and equivalent technologies thereof, then the present invention is also intended to comprise these change and modification.
Claims (10)
1. a ultra-fine polyglycollide fibre, is characterized in that, the span of the diameter of described ultra-fine polyglycollide fibre is 5 μm ~ 15 μm, and the span of the intensity of described ultra-fine polyglycollide fibre is 3.0cN/dtex ~ 7.0cN/dtex.
2. the preparation method of ultra-fine polyglycollide fibre according to claim 1, is characterized in that, comprise the following steps:
PGA resin and second component are extruded respectively and obtains spun filament;
Drafting forming is carried out to described spun filament, obtains the first intermediate product;
Post processing is carried out to described first intermediate product, obtains the second intermediate product;
Described second intermediate product is washed, obtains described ultra-fine polyglycollide fibre;
As preferably, the span of the relative viscosity of described PGA is 1.0dl/g ~ 2.0dl/g;
As preferably, described second component is selected from the one in PLA, PGLA370, PGLA280, PDO, PCL;
As preferably, the span of the mass ratio of described PGA resin and second component resin is (10: 90) ~ (90: 10);
As preferably, when carrying out drafting forming to described spun filament, the span of drafting multiple is 3.0 times ~ 6.0 times;
As preferably, when carrying out drafting forming to described spun filament, the span of drafting multiple is 4.5 times ~ 5.5 times;
As preferably, when carrying out drafting forming to described spun filament, the span of setting temperature is 100 DEG C ~ 130 DEG C;
As preferably, when carrying out drafting forming to described spun filament, the span of setting temperature is 115 DEG C ~ 125 DEG C;
As preferably, when carrying out drafting forming to described spun filament, the span of shaping time is 1 ~ 3h;
As preferably, carry out post processing to described first intermediate product, the method obtaining the second intermediate product is selected from:
Through being compiled into tricot, or,
Weft-knitted fabric is made in weft knitting, or,
Composite short fiber is made in curling cut-out, then described composite short fiber water thorn or acupuncture is prepared into nonwoven fabric;
As preferably, the method for washing described second intermediate product is ultrasonic washing by soaking;
As preferably, the span of described ultrasonic washing by soaking duration is 2h ~ 5h;
As preferably, when washing described second intermediate product, the solvent of application is the solvent of soluble solution PGA resin;
As preferably, the one in the solvent selected from acetone of application when described second intermediate product is washed, DMAC, 1-METHYLPYRROLIDONE, carrene;
As preferably, described PGA resin and second component being extruded respectively obtains spun filament and comprises the following steps:
By standby for described PGA resin-made uniformly the first melt;
Described second component is prepared into uniform second melt;
Described first melt, the second melt are extruded after measuring, forms compounding flux thread;
Described compounding flux thread is cooled, obtains described spun filament;
As preferably, when cooling described compounding flux thread, the span of the temperature of cooling air is 20 DEG C ~ 30 DEG C;
As preferably, when cooling described compounding flux thread, the span of the humidity of cooling air is 20% ~ 30%;
As preferably, when cooling described compounding flux thread, the span of the cold air blast velocity of cooling air is 0.4m/s ~ 1m/s.
3. the preparation facilities of ultra-fine polyglycollide fibre according to claim 1, is characterized in that, comprises spun filament preparation facilities, drafting-shaping device, weaving textile device, wash mill,
Described spun filament preparation facilities is used for PGA resin and second component to extrude respectively, obtains described spun filament;
Described drafting-shaping device is used for carrying out drafting forming to described spun filament, obtains the first intermediate product;
Described weaving textile device is used for carrying out post processing to described first intermediate product, obtains the second intermediate product;
Described wash mill is used for washing described second intermediate product, obtains described ultra-fine polyglycollide fibre;
As preferably, described spun filament preparation facilities comprises the first screw extruder, the second screw extruder, metering device, the first transfer pipeline, the second transfer pipeline, extrusion die, cooling device,
Described first screw extruder is used for standby for described PGA resin-made uniformly the first melt;
Described second screw extruder is used for described second component to be prepared into uniform second melt;
Described metering device is used for measuring described first melt, the second melt;
Described first transfer pipeline is for carrying described first melt to exit, described extrusion die plate face;
Described second transfer pipeline is for carrying described second melt to exit, described extrusion die plate face;
Described extrusion die is used for making described first melt, the second melt from exit, described extrusion die plate face compound extruded, forms compounding flux thread;
Described cooling device is used for cooling described compounding flux thread;
As preferably, described metering device comprises the first metering device, the second metering device,
Described first metering device is used for measuring described first melt;
Described second metering device is used for measuring described second melt;
As preferably, described first metering device is the first measuring pump, and described second metering device is the second measuring pump;
As preferably, described extrusion die is provided with the first melt extrusion micropore, the second melt extrusion micropore;
As preferably, described first melt extrusion micropore is at least 2, and described second melt extrusion micropore is arranged between described first melt extrusion micropore.
4. the preparation facilities of ultra-fine polyglycollide fibre according to claim 3, is characterized in that, described cooling device is cooling air generating means.
5. the preparation facilities of ultra-fine polyglycollide fibre according to claim 4, is characterized in that, described cooling air generating means is provided with temperature setting module, humidity set module, cold air blast velocity setting module,
Described temperature setting module is used for setting the temperature of cooling air;
Described humidity set module is used for setting the humidity of described cooling air;
Described cold air blast velocity setting module is used for setting described cold air blast velocity.
6. the preparation facilities of ultra-fine polyglycollide fibre according to claim 5, is characterized in that, also comprise intelligent terminal, and described intelligent terminal is provided with signal setting module,
Described temperature setting module is provided with the first remote interface,
Described humidity set module is provided with the second remote interface,
Described cold air blast velocity setting module is provided with the 3rd remote interface,
Described intelligent terminal can be set the temperature of described cooling air, humidity, cold air blast velocity respectively by described signal setting module, the first remote interface, the second remote interface, the 3rd remote interface.
7. the preparation facilities of ultra-fine polyglycollide fibre according to claim 6, is characterized in that, described signal setting module is an APP.
8. the preparation facilities of ultra-fine polyglycollide fibre according to claim 3, is characterized in that, one or more in the shape selected from circles of described first melt extrusion micropore, ellipse, fan-shaped, quincunx, polygon.
9. the purposes of ultra-fine polyglycollide fibre according to claim 1, is characterized in that, described ultra-fine polyglycollide fibre is used for the purposes of sticking patch;
As preferably, described sticking patch is light and thin type Absorbable rod sticking patch.
10. a sticking patch, is characterized in that, the material for making described sticking patch comprises ultra-fine polyglycollide fibre according to claim 1.
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108096642A (en) * | 2017-12-07 | 2018-06-01 | 中国纺织科学研究院 | Absorbable film layer, adsorbable hemostatic agents and preparation method thereof |
| CN111905149A (en) * | 2020-07-30 | 2020-11-10 | 中国纺织科学研究院有限公司 | Anti-sticking partially absorbable tissue repair material and preparation method thereof |
| CN112915256A (en) * | 2021-01-11 | 2021-06-08 | 华南理工大学 | Method for preparing human dura mater repair material with imitated ECM (extracellular matrix) components and structure by long fiber network framework preforming method |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1584143A (en) * | 2004-06-11 | 2005-02-23 | 清华大学 | Preparing method for growth factor slow-releasing system for tissue repair |
| CN101128226A (en) * | 2004-11-24 | 2008-02-20 | 生物合成物有限公司 | Bioabsorbable composite material fiber |
| WO2013161755A1 (en) * | 2012-04-27 | 2013-10-31 | 株式会社クレハ | Short polyglycolic-acid-resin fibers and well-treatment fluid |
| CN103603087A (en) * | 2013-11-15 | 2014-02-26 | 无锡中科光远生物材料有限公司 | Preparation method of nanofiber for soft tissue regeneration |
-
2015
- 2015-11-25 CN CN201510831640.1A patent/CN105420848B/en active Active
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1584143A (en) * | 2004-06-11 | 2005-02-23 | 清华大学 | Preparing method for growth factor slow-releasing system for tissue repair |
| CN101128226A (en) * | 2004-11-24 | 2008-02-20 | 生物合成物有限公司 | Bioabsorbable composite material fiber |
| WO2013161755A1 (en) * | 2012-04-27 | 2013-10-31 | 株式会社クレハ | Short polyglycolic-acid-resin fibers and well-treatment fluid |
| CN103603087A (en) * | 2013-11-15 | 2014-02-26 | 无锡中科光远生物材料有限公司 | Preparation method of nanofiber for soft tissue regeneration |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108096642A (en) * | 2017-12-07 | 2018-06-01 | 中国纺织科学研究院 | Absorbable film layer, adsorbable hemostatic agents and preparation method thereof |
| CN111905149A (en) * | 2020-07-30 | 2020-11-10 | 中国纺织科学研究院有限公司 | Anti-sticking partially absorbable tissue repair material and preparation method thereof |
| CN112915256A (en) * | 2021-01-11 | 2021-06-08 | 华南理工大学 | Method for preparing human dura mater repair material with imitated ECM (extracellular matrix) components and structure by long fiber network framework preforming method |
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| CN105420848B (en) | 2019-12-24 |
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