CN112210888B - Polylactic acid elastic non-woven material beneficial to tissue regeneration and preparation method thereof - Google Patents

Polylactic acid elastic non-woven material beneficial to tissue regeneration and preparation method thereof Download PDF

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CN112210888B
CN112210888B CN202011145491.0A CN202011145491A CN112210888B CN 112210888 B CN112210888 B CN 112210888B CN 202011145491 A CN202011145491 A CN 202011145491A CN 112210888 B CN112210888 B CN 112210888B
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polylactic acid
elastic
nano
woven material
tissue regeneration
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CN112210888A (en
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张恒
甄琪
崔景强
程杰
王先锋
王国峰
刘志远
张永祥
孙焕惟
牛犇
王诗文
段泽平
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Henan Tuoren Medica Device Co ltd
Zhongyuan University of Technology
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Henan Tuoren Medica Device Co ltd
Zhongyuan University of Technology
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    • D—TEXTILES; PAPER
    • D04—BRAIDING; LACE-MAKING; KNITTING; TRIMMINGS; NON-WOVEN FABRICS
    • D04H—MAKING TEXTILE FABRICS, e.g. FROM FIBRES OR FILAMENTARY MATERIAL; FABRICS MADE BY SUCH PROCESSES OR APPARATUS, e.g. FELTS, NON-WOVEN FABRICS; COTTON-WOOL; WADDING ; NON-WOVEN FABRICS FROM STAPLE FIBRES, FILAMENTS OR YARNS, BONDED WITH AT LEAST ONE WEB-LIKE MATERIAL DURING THEIR CONSOLIDATION
    • D04H1/00—Non-woven fabrics formed wholly or mainly of staple fibres or like relatively short fibres
    • D04H1/40—Non-woven fabrics formed wholly or mainly of staple fibres or like relatively short fibres from fleeces or layers composed of fibres without existing or potential cohesive properties
    • D04H1/42—Non-woven fabrics formed wholly or mainly of staple fibres or like relatively short fibres from fleeces or layers composed of fibres without existing or potential cohesive properties characterised by the use of certain kinds of fibres insofar as this use has no preponderant influence on the consolidation of the fleece
    • D04H1/4382—Stretched reticular film fibres; Composite fibres; Mixed fibres; Ultrafine fibres; Fibres for artificial leather
    • A—HUMAN NECESSITIES
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    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/0063—Implantable repair or support meshes, e.g. hernia meshes
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    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
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    • A61L15/22—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing macromolecular materials
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    • A61L15/22—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing macromolecular materials
    • A61L15/26—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds; Derivatives thereof
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    • A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
    • A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
    • A61L15/22—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing macromolecular materials
    • A61L15/28—Polysaccharides or their derivatives
    • A—HUMAN NECESSITIES
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    • A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
    • A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
    • A61L15/42—Use of materials characterised by their function or physical properties
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    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/14—Macromolecular materials
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    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/14—Macromolecular materials
    • A61L27/18—Macromolecular materials obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
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    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
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    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
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    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/56—Porous materials, e.g. foams or sponges
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    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/58—Materials at least partially resorbable by the body
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    • D04H1/00—Non-woven fabrics formed wholly or mainly of staple fibres or like relatively short fibres
    • D04H1/40—Non-woven fabrics formed wholly or mainly of staple fibres or like relatively short fibres from fleeces or layers composed of fibres without existing or potential cohesive properties
    • D04H1/44—Non-woven fabrics formed wholly or mainly of staple fibres or like relatively short fibres from fleeces or layers composed of fibres without existing or potential cohesive properties the fleeces or layers being consolidated by mechanical means, e.g. by rolling
    • D04H1/46—Non-woven fabrics formed wholly or mainly of staple fibres or like relatively short fibres from fleeces or layers composed of fibres without existing or potential cohesive properties the fleeces or layers being consolidated by mechanical means, e.g. by rolling by needling or like operations to cause entanglement of fibres
    • D04H1/492—Non-woven fabrics formed wholly or mainly of staple fibres or like relatively short fibres from fleeces or layers composed of fibres without existing or potential cohesive properties the fleeces or layers being consolidated by mechanical means, e.g. by rolling by needling or like operations to cause entanglement of fibres by fluid jet
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    • D04H1/00—Non-woven fabrics formed wholly or mainly of staple fibres or like relatively short fibres
    • D04H1/70—Non-woven fabrics formed wholly or mainly of staple fibres or like relatively short fibres characterised by the method of forming fleeces or layers, e.g. reorientation of fibres
    • D04H1/76—Non-woven fabrics formed wholly or mainly of staple fibres or like relatively short fibres characterised by the method of forming fleeces or layers, e.g. reorientation of fibres otherwise than in a plane, e.g. in a tubular way
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    • D06C11/00—Teasing, napping or otherwise roughening or raising pile of textile fabrics
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    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
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    • A61L2430/00—Materials or treatment for tissue regeneration
    • A61L2430/34—Materials or treatment for tissue regeneration for soft tissue reconstruction

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Abstract

The invention discloses a polylactic acid elastic non-woven material beneficial to tissue regeneration and a preparation method thereof. The nano-micron polylactic acid elastic non-woven material is an integral structure which is formed by taking polylactic acid nano-micron fibers as a main body and taking polyolefin elastic filaments as a framework. The preparation method comprises the following steps: carrying out in-situ spray forming on the modified polylactic acid polymer and the polyolefin elastic framework to obtain a laminated fiber web, carrying out water jet composite processing on the laminated fiber web to form an integral structure, and then carrying out single-side ironing on the integral structure fiber web to obtain the nano-micron elastic light patch and the preparation method thereof. The non-woven material prepared by the method has an integrated structure, is not layered, has a good anti-adhesion effect, has excellent elasticity and flexibility, and can be used in various fields such as hernia patches, medical dressings and medical bandages. The preparation method of the non-woven patch has the characteristics of short process flow, high production speed and low cost, and is suitable for large-scale industrial production.

Description

Polylactic acid elastic non-woven material beneficial to tissue regeneration and preparation method thereof
Technical Field
The invention belongs to the field of non-woven materials, relates to a polylactic acid elastic non-woven material beneficial to tissue regeneration, and particularly relates to a polylactic acid elastic non-woven material beneficial to tissue regeneration and a preparation method thereof.
Background
With the rapid development of medical fiber technology in recent years, the functional non-woven material based on specific raw materials can be used as a base material for cell culture to accelerate the growth of tissues, and can also be used for covering skin trauma to facilitate the healing of the trauma, so that the non-woven material is widely applied to the fields of hernia patches, medical dressings, medical bandages and the like to repair hernias and skin wounds.
Hernia refers to a part of a body tissue or organ leaving the original site and entering another site through a gap, defect or weak site of the body, and is one of the common and frequently encountered diseases in general surgery. The hernia is frequently generated at the positions of the abdomen (abdominal wall and umbilicus) and groin, accompanied by pain, and the normal walking and living of the patient are affected by light persons, so that not only are serious physiological and psychological effects brought to the patient, but also hernia masses can be gradually enlarged due to untimely treatment, and the intestinal ischemia necrosis threatens the life of the patient, and therefore, effective treatment should be performed as early as possible.
To date, implantation of hernia repair materials (referred to as "hernia patches") remains the primary treatment. The hernia patch is suitable for covering the damaged part, replaces the defected tissue to a certain extent, and has the characteristics of no joint tension, small operation injury, quick recovery and small pain. Therefore, the hernia patch serving as an implantable medical appliance can meet the requirements of good biological inertia and biocompatibility in a complex biological environment, and is also adaptive to the physiological characteristics of human abdominal wall tissues, so that the patch can be used for permanently repairing the hernia. The hernia patch is therefore required to have the following properties:
(1) safe, the hernia patch should be made of high molecular material with good biocompatibility. Various degradable materials including polylactic acid are used. For example, patent CN201710450595.4 proposes to use polylactic acid and collagen as raw materials to prepare a composite biological membrane for hernia repair.
(2) The patch is light in weight and light in weight, has higher compliance, can effectively reduce the foreign body sensation and discomfort after the patch is implanted into a body, and further reduces the stimulation of the patch to local tissues and nerves.
(3) Has certain flexibility and elasticity to adapt to different surgical requirements; for example, patent US20140135407a1 proposes a patch made of a biodegradable elastomeric polymer based on polylactic acid to obtain a patch with high tensile or compressive forces for tissue repair.
(4) The hole design is used for increasing the tissue ingrowth and reducing the foreign body content, infection and inflammatory reaction after the patch is implanted; for example, US9486302B2 proposes a polylactic acid multilayer sheet structure in which one layer is a porous layer having high friction and the other layer has fine pores having anti-blocking properties.
As can be seen, the development of elastic nonwoven materials made of polylactic acid for tissue repair such as hernia treatment and dressing has been a focus of research, and product development and structural design have been made around their applicability. At present, the existing polylactic acid patch structures are mainly divided into two categories.
(1) The single structure mainly comprises a single woven structure, a single membrane structure and a single non-woven structure. CN201610040930.9, for example, proposes to knit medical grade polypropylene monofilaments with medical grade polylactic acid monofilaments to obtain a mesh-structured patch; patent CN200910103418.4 utilizes electrospinning technology to prepare a biological patch combining polylactic acid or/and polycaprolactone with collagen or/and silk fibroin.
(2) The composite structure is mainly used for overcoming the defect that the performance of a single structure is single and the composite characteristic cannot be provided, a multi-layer anisotropic structure is subjected to composite treatment after lamination, and mostly a nano-micron fiber net with a compact structure is compounded with a macroporous fiber layer to obtain an anti-adhesion effect and a light structure. For example, CN201610040874.9 proposes compounding a polylactic acid/polycaprolactone electrospun membrane with a polypropylene warp knitted web using an adhesive to prepare a composite structured patch. CN201821497109.0 is an anti-adhesion hernia repair patch which is composed of a hyaluronic acid base layer, a non-absorbable high molecular polymer monofilament layer and a polylactic acid layer. CN 201410812046.3 proposes a double-layer membrane structure prepared by an electrostatic spinning technology, wherein one layer is a compact layer prepared by biological fibers with longer degradation time, and the other layer is a potential loose layer prepared by mixing biological fibers with different degradation times.
However, the clinical application also finds that the interlayer composite structure has the layering problem, the microstructure and the use effect of the fiber are influenced, and meanwhile, the nano-micron fiber net prepared by electrostatic spinning has the characteristics of solvent residue and excessively complex processing technology, and the safety and the environmental protection performance of industrial production are insufficient.
Disclosure of Invention
Regarding the non-woven material which is beneficial to tissue regeneration, the large aperture (> 1.5 mm) is beneficial to the tissue ingrowth, reduces the foreign matter content, infection and inflammatory reaction after the patch is implanted, and reduces the formation of scar plate; the pores (10-50 mu m) are beneficial to the rapid growth of fibroblasts and new blood vessels, so that the fibroblasts and the new blood vessels can be better fused with surrounding tissues; while superfine pores (< 2 μm) generally have better anti-blocking effect. Nonwoven materials with a combination of pore sizes are good substrates for tissue regeneration. Regarding the characteristics of the non-woven material implanted in vivo, the non-absorbable material has the advantages of stable mechanical property and low recurrence rate, the absorbable material has better biocompatibility, the inflammatory reaction is reduced, but the degradation of the material can cause the reduction of the strength and the recurrence. The combined use of absorbable and non-absorbable materials is a beneficial option to endow the implant material with tissue regeneration and guarantee of therapeutic effect in vivo. Therefore, for the suitability of nonwoven materials for implantation in vivo, the nonwoven materials are required to have not only certain elasticity and flexibility but also conformability to the damaged area, thereby facilitating the recovery of tissue growth and accommodating the deformation of the skin.
In order to solve the technical problems, the invention provides a polylactic acid elastic non-woven material beneficial to tissue regeneration and a preparation method thereof, and the technical scheme of the invention is realized as follows:
the preparation method of the polylactic acid elastic non-woven material beneficial to tissue regeneration comprises the following steps:
(1) preparation of polyolefin elastic filament framework: taking a polyolefin elastic filament framework as a base material, and performing antibacterial treatment;
(2) preparation of polylactic acid nano microfiber: taking polylactic acid polymer and functional polymer as raw materials, blending, feeding the raw materials into a screw extruder to be softened and melted into blended melt, and then extruding the blended melt through a spinneret orifice to form polylactic acid nano microfiber;
(3) compounding the framework and the fibers: laying the polylactic acid nano microfibers prepared in the step (2) on the polyolefin elastic filament framework treated in the step (1), respectively blowing and holding the polylactic acid nano microfibers to two sides of the polyolefin elastic filament framework by utilizing air flows at the upper side and the lower side and suction air, and compounding and preparing the polylactic acid nano microfibers/polyolefin elastic filament framework/polylactic acid nano microfibers composite material with a nano-micron brooming form by utilizing an ironing and polishing-sanding process;
(4) formation of polylactic acid elastic nonwoven material: and (3) intermittently impacting the side, with the nano-micron brooming form, of the polylactic acid nano microfiber/polyolefin elastic filament framework/polylactic acid nano microfiber composite material prepared in the step (3) by utilizing high-pressure water jet, so that the polylactic acid nano microfiber is flushed and embedded into the polyolefin elastic filament framework to form an integrated structure, and meanwhile, brooming holes are formed in one side by utilizing the cooperation of the high-pressure water jet and a rotary drum/screen curtain, so that the polylactic acid elastic nonwoven material beneficial to tissue regeneration is prepared.
Further, the antibacterial treatment in the step (1) means that an antibacterial layer with the thickness of 0.01-1 μm is attached to the surface of the polyolefin elastic filament skeleton in one or more forms of spraying, coating and soaking; the antibacterial layer is a bio-based antibacterial material with a degradation period of 40-50 days, and the bio-based antibacterial material is one or a mixture of chitosan and derivatives, hyaluronic acid and derivatives.
Further, the section of the polyolefin elastic filament in the step (1) is circular, oval or triangular; the surface roughness of the polyolefin elastic filament can be one or a combination of holes and threads.
Further, the solubility ratio of the functional polymer to the polylactic acid polymer in the step (2) is 1 (1.05-10), and the melting peak value of the functional polymer to the polylactic acid polymer is 0-20 ℃;
wherein the polylactic acid polymer is levorotatory polylactic acid and racemic polylactic acid, the weight-average molecular weight is 100000-5000000, and the molecular weight distribution is 1.0-5; the functional polymer is in the form of one or more of polycaprolactone, polyglycolide, polylactide-acetic acid copolymer, polycarbonic ester, polyethylene glycol-b-polylactic acid and cellulose copolymer, and functional components for promoting wound healing, such as antibacterial drugs or cell growth factors, are also doped in the functional polymer.
Further, the blending in the step (2) is carried out by mixing the particles, respectively melting into melts or preparing the particles into a solution by using a solvent.
Furthermore, the air flow and the suction wind on the upper side and the lower side in the step (3) are formed by stacking 2 groups or more than 2 groups of negative pressure fans which are symmetrical left and right and up and down, and the air flow and the suction wind are distributed in a vertically symmetrical manner.
Further, the ironing and polishing process in the step (3) is to arrange the three-layer structure of polylactic acid nano microfiber/polyolefin elastic filament skeleton/polylactic acid nano microfiber into a fiber assembly with a smooth surface by using a single-side ironing and polishing process; wherein the sanding process refers to that one side of polylactic acid nano microfiber is arranged into a velvet structure with the length of 0.1-100 μm.
Further, the high-pressure water jet in the step (4) is characterized in that the initial fineness of the water jet is 0.1mm-0.2 mm; the intermittent frequency is as follows: line speed/pitch; the intermittent barrier is in the form of a regularly moving drum and/or curtain.
Further, the mesh curtain in the step (4) is a laminated and crossed structure of chemical fiber filaments and metal wires, and is structurally characterized in that: 18-103 mesh, wherein the chemical fiber filament is polyester or polyamide filament, the metal wire is stainless steel and/or nickel, and the surface density of the integrated structure is 15-300g/m2The bulk density is 0.05-0.30 g/m3。
The polylactic acid elastic non-woven material which is prepared by the method and is beneficial to tissue regeneration takes polylactic acid fiber with the average diameter of 0.3-4 mu m as a main body, and one side of the polylactic acid elastic non-woven material consisting of polyolefin elastic filament skeletons with the diameter of 10-200 mu m is provided with an integrated structure of broomed holes; the transverse elongation of the polylactic acid elastic non-woven material is 146-260%, the transverse elastic recovery rate is 75-86%, the longitudinal breaking elongation is 75-135%, and the longitudinal elastic recovery rate is 33-56%; the polylactic acid fiber is characterized in that the number proportion of the included angle between the length direction of the fiber and the longitudinal direction is-20 degrees is 50-80 percent.
Further, the polyolefin elastic filament backbone is characterized by a roughness of 0.5-50 filaments arranged in a criss-cross pattern with a filament spacing of (0.5-1) cm.
Furthermore, the broomed holes are characterized in that the area of the holes is 35-50%, and the depth of the holes is 0.01-1 mm.
The invention has the following beneficial effects:
1. the polylactic acid elastic non-woven material beneficial to tissue regeneration, prepared by the application, makes full use of the material biodegradation characteristic and the non-woven structure advantage of polylactic acid, is an integrated structure form with flexibility, elasticity and various pore characteristics, can meet the technical requirements of the polylactic acid elastic non-woven material applied in the fields of hernia repair, medical dressings, medical bandages and the like, and achieves the purposes of promoting wound healing and characteristic treatment.
2. The nonwoven material has pore sizes of various scales: firstly, one side of the broom hole is provided with 30-60% of opening area and 0.01-1mm of opening depth, so that the rapid growth of tissues can be ensured; the inner sides of the holes are provided with the villiform broomed polylactic acid nano-micron fibers with the length of 0.1-100 mu m, so that the cell growth can be effectively enhanced, and the regeneration and early-stage fixation of tissues are facilitated; and thirdly, pores 8-20 microns between the polylactic acid main body fibers with the diameter of 0.3-4 microns can well promote cells and new blood vessels to grow in quickly, so that tissue fusion is facilitated.
3. When the polylactic acid elastic non-woven material which is beneficial to tissue regeneration and prepared by the application is used as a patch, the unique unidirectional extension elasticity is endowed by the integral structure of the polylactic acid elastic non-woven material; the superfine fiber main body structure and the physical entanglement form endow the superfine fiber with excellent flexibility, and the flexibility is 30-95 as can be known by a PhabrOmeter test method (AATCC TM 202); therefore, the fabric is different from the traditional woven structure, is not easy to adhere to tissues in the viscera repairing process, plays a good role in separation, and has the characteristics of good flexibility and no skin irritation in the treatment process. The ratio of the longitudinal elastic recovery rate to the transverse elastic recovery rate of the sample of the invention is 1: 5, therefore, the composite material has wider application range, better usability, convenient operation, high unidirectional tensile strength and no displacement.
4. The non-woven material takes the polyolefin elastic filaments as the framework, and has high strength and good fixing performance; therefore, the stability of the early application and the sustainability and later-period deformability of the treatment effect can be ensured, and the capacity of relapse prevention is also realized; meanwhile, the main component of the non-woven material is polylactic acid fiber which has the degradable characteristic, so that the non-woven material has good biocompatibility and histocompatibility in the implantation period.
5. Compared with the traditional hot-pressing composite material, the non-woven material belongs to physical entanglement, polylactic acid fibers and polyolefin filaments are mutually crossed and entangled into an integral structure, can be randomly cut into various shapes in the using process, cannot be layered, has use convenience, and can be applied to a plurality of fields such as hernia repair, medical dressings and medical bandages.
6. The preparation method does not involve the use of chemical solvents, so compared with the traditional electrostatic spinning process, the preparation method has the characteristics of no solvent residue, greenness, environmental protection and low cost.
Drawings
In order to more clearly illustrate the embodiments of the present invention or the technical solutions in the prior art, the drawings used in the description of the embodiments or the prior art will be briefly described below, it is obvious that the drawings in the following description are only some embodiments of the present invention, and for those skilled in the art, other drawings can be obtained according to the drawings without creative efforts.
FIG. 1 is a surface view of a nano-micro polylactic acid elastic nonwoven material according to the present invention. Wherein, 1-1 is polylactic acid nano microfiber, 1-2 is polyolefin elastic filament skeleton, and 1-3 is brooming hole.
FIG. 2 is a schematic cross-sectional view of a nano-micro polylactic acid elastic nonwoven material according to the present invention. Wherein 2-1 is polylactic acid nano microfiber, 2-2 is brooming holes, and 2-3 is polyolefin elastic filament skeleton.
FIG. 3 is a schematic view of the process flow of the combination of the filament skeleton and polylactic acid nano-microfiber. Wherein 3-1-1 is hot air, 3-2-1 is polymer melt, 3-3-1 is an upper melt-blown component, 3-4-1 is upper polylactic acid nano microfiber, 3-5-1 is upper polylactic acid nano microfiber net, 3-1-2 is hot air, 3-2-2 is polymer melt, 3-3-2 is a lower melt-blown component, 3-4-2 is lower polylactic acid nano microfiber, 3-5-2 is lower polylactic acid nano microfiber net, 3-6 is polyolefin elastic filament skeleton, 3-7-1 is an upper press roll, 3-7-2 is a lower press roll, 3-8-1 is an upper burr roll, 3-8-2 is a lower burr roll, 3-8 is polylactic acid microfiber sodium/polyolefin elastic filament skeleton/polylactic acid sodium microfiber composite microfiber A material.
FIG. 4 is a schematic view of the process flow of the integrated structure for brooming holes. Wherein 4-1 is a fiber web, 4-2-1-1 is an upper net curtain, 4-2-1-2 is a net supporting curtain, 4-2-1-2 is an upper rotary drum, 4-2-2-2 is a supporting drum, 4-3 is a spunlace head, 4-4 is a high-pressure water jet, 4-5 is a vacuum suction device, and 4-6 is a brooming hole.
FIG. 5 is the electron microscope image of the morphology of the polylactic acid nano-micron fiber.
Fig. 6 is a graph of the PhabrOmeter test.
FIG. 7 is a graph showing the effect of the antibacterial treatment.
FIG. 8 is a diagram of the polylactic acid nano microfiber/polyolefin elastic filament skeleton/polylactic acid nano microfiber composite material according to the present invention.
Fig. 9 is a representation of the polylactic acid elastic nonwoven material of the present invention.
Detailed Description
The adopted raw materials of the nano-micron polylactic acid elastic non-woven material and the functional polymer are thermoplastic polymers, wherein the polylactic acid polymer is polylactic acid and/or racemic polylactic acid, the weight-average molecular weight is 100000-5000000, and the molecular weight distribution is 1.0-5; the functional polymer is one or more of polycaprolactone, polyglycolide, polylactide-acetic acid copolymer, polycarbon ester, polyethylene glycol-b-polylactic acid and cellulose copolymer.
Wherein the solubility ratio of the lactic acid polymer to the functional polymer is 1 (1.05-10), and the melting peak value is 0-20 ℃.
The solubility parameter ratio is a ratio of solubility parameters of two polymer materials, and is used for characterizing the compatibility of the two polymer materials, and generally, the closer the solubility parameter ratio is to 1, the higher the compatibility is.
The technical solutions of the present invention will be described clearly and completely with reference to the following embodiments of the present invention, and it should be understood that the described embodiments are only a part of the embodiments of the present invention, and not all of the embodiments. All other embodiments, which can be obtained by a person skilled in the art without inventive effort based on the embodiments of the present invention, are within the scope of the present invention.
Example 1
The preparation method of the polylactic acid elastic non-woven material beneficial to tissue regeneration comprises the following steps:
(1) preparing a polyolefin elastic filament framework:
first, an elastic polyolefin filament having an average diameter of 100 μm and a circular cross-section was selected and subjected to an antibacterial treatment.
The selected bio-based antibacterial material is chitosan solution, a certain amount of chitosan is dissolved in citric acid with the mass fraction of 20%, and the chitosan solution with the mass fraction of 1% is prepared.
Firstly, the prepared polyolefin filaments are subjected to low-temperature plasma treatment, so that hydroxyl groups (-COOH) are introduced on the polyolefin filaments, and the hydroxyl groups can be combined with amino groups in chitosan, thereby fixing the chitosan and endowing the chitosan with excellent antibacterial performance. Then immersing the chitosan into a chitosan solution for 24 hours at the temperature of 4 ℃, and taking out and drying; the average thickness of the obtained antibacterial layer is 0.8 mu m;
(2) preparation process of polylactic acid nano microfiber:
the levorotatory polylactic acid and polycaprolactone with the weight-average molecular weight of 2000000 are used as raw materials, and the mixing ratio is 5: 1. Firstly, putting the polylactic acid and polycaprolactone master batch into an electrothermal blowing dryer at 80 ℃ for drying for 8h, then putting the mixture into a high-speed mixer, adding the antibacterial agent and cell growth factor powder, fully mixing the antibacterial agent and the cell growth factor powder, blending the mixture, then sending the mixture into a screw extruder for softening and melting to form a blended melt, and then extruding the blended melt through a spinneret orifice to form polylactic acid nano microfiber.
The specific melt-blown process parameters are set as follows: metering pump temperature 200 ℃, melt-blown die temperature 220 ℃, screw extruder temperature (first zone-fourth zone): 160 ℃, 180 ℃, 200 ℃ and 220 ℃; 20 min after rotating speed of metering pump 7r -120, fan speed 45r & min -120. coiling speed 1.7 min-1And an acceptance distance of 20 cm. The diameter of the obtained nano-micron polylactic acid/polycaprolactone fiber is 2.2 μm on average.
(3) Compounding the polyolefin elastic filament skeleton and the polylactic acid nano microfiber:
and (2) arranging the polyolefin elastic filament frameworks prepared in the step (1) in a cross-shaped mode, wherein the filament spacing is 1cm x 1cm, preparing the polyolefin elastic filament frameworks into a rectangular grid shape with the width of 30cm, and respectively blowing and holding the polylactic acid nano microfibers obtained in the step (2) to two sides of the polyolefin elastic filament frameworks by utilizing 2 groups of air flows at the upper side and the lower side and the cooperation of air suction and air suction.
The specific process is shown in figure 3, hot air 3-1-1 at the upper layer drives polymer melt 3-2-1 to be sprayed out from a melt-blowing component 3-3-1 at the upper layer, and the polymer melt is drafted at high speed to form polylactic acid nano microfiber 3-4-1 at the upper layer and is deposited on the upper side of a polyolefin elastic filament framework 3-6 to form a polylactic acid nano microfiber web 3-5-1 at the upper layer; meanwhile, the hot air 3-1-2 at the lower layer drives the polymer melt 3-2-2 to be sprayed out from the lower layer melt-blowing component 3-3-2, and the polymer melt is drawn into the lower layer polylactic acid nano microfiber 3-4-2 at a high speed and further deposited on the lower side of the polyolefin elastic filament framework 3-6 to form a lower layer polylactic acid nano microfiber web 3-5-2.
(4) The ironing and polishing process comprises the following steps:
and (4) performing surface polishing and sanding treatment on the fiber web with the three-layer structure of polylactic acid nano microfiber/polyolefin elastic filament framework/polylactic acid nano microfiber prepared in the step (3) to obtain the fiber web.
As shown in FIG. 3, the three-layer fiber web formed in step (3) is first hot-rolled and bonded and single-sided ironed by a pair of hot-rolled rolls, wherein the upper roll is an ironing roll 3-7-1, the lower roll is a heating steel roll 3-7-2, the roll temperature is set to 120 ℃, the roll pressure is 25N, and the production speed is 120 m/min.
Further, sanding the obtained composite fiber web, arranging polylactic acid nano microfiber at one side into a velvet shape, and sanding the composite fiber web on a single side by using a sandpaper with the number of 1500 to form a nano-scale wool layer, wherein the pressure of a clamping friction process is 0.1 Mpa; as shown in figure 3, in the sanding process, the three-layer composite fiber web is subjected to the pressure action of an upper sanding roller 3-8-1 and a lower sanding roller 3-8-2, and the friction action of a sand skin on the surface of the fiber web is generated by utilizing the speed difference, so that the polylactic acid nano microfiber/polyolefin elastic filament skeleton/polylactic acid nano microfiber composite material 3-8 with the surface having the fluff effect is obtained.
Further, the volume density of the obtained composite fiber aggregate is 65%, and the polylactic acid nano microfiber is arranged into a velvet shape with the length of 20-80 μm.
(5) Brooming the integrated structure process of the hole:
and (3) intermittently impacting the side, with the nano-micron brooming form, of the fiber web obtained in the step (4) by using a spunlace process, flushing and embedding polylactic acid nano microfibers into the polyolefin elastic filament yarn framework to form an integrated structure by using high-pressure water jets, and forming brooming holes on one side by using the cooperation of the high-pressure water jets and the rotary drum or the net curtain to form the polylactic acid elastic nonwoven composite material. Referring to fig. 4, the difference of the hydroentangling pattern can divide the integrated structure process of the brooming hole into a curtain type (fig. 4-a) and a drum type (fig. 4-B).
This example employs a curtain. As shown in fig. 4-a, the fiber web 4-1 is conveyed to the area of the spunlace head 4-3 under the clamping of the supporting mesh 4-2-1-2 and the upper mesh 4-2-1-1, and the high-pressure water jet 4-4 rapidly penetrates through the upper mesh/fiber web/supporting mesh and is discharged through the vacuum suction device; during the process that the high-pressure water jet penetrates through the upper net curtain, regularly distributed brooming holes are generated due to the intermittent blocking of the upper net curtain.
Further, in this example, the diameter of the water needle plate of the composite fiber web of nano-micro polylactic acid subjected to high pressure water jet is 0.1mm, the impact energy is 285J/kg, the aperture of the used net curtain is 50 meshes, and the areal density of the obtained elastic nonwoven material of nano-micro polylactic acid is 108.1 g/m2The thickness is 0.709mm, the opening area of the formed brooming hole is about 35%, and the opening depth is 0.01-1 mm.
(6) And (3) sterilization treatment:
and (3) sterilizing the polylactic acid elastic non-woven composite material prepared in the step (5) by using an ethylene oxide sterilization method, and putting the obtained lactic acid elastic non-woven composite material into an ethylene oxide low-temperature sterilizer at the set temperature of 35 ℃ for 3 hours with the relative environmental humidity of 70% +/-10%.
The nano-micron polylactic acid elastic nonwoven material prepared by the embodiment relates to drying treatment in the multiple steps, and the invention is not limited to the drying form and the drying process, and can be in various forms such as hot air penetration, hot roller contact, infrared radiation drying and the like.
The obtained nano-micron polylactic acid elastic nonwoven material is tested for the surface density, the thickness, the bursting strength, the tensile mechanical property and the like, the schematic surface structure diagram of the nano-micron polylactic acid elastic nonwoven material is shown in figure 1, the schematic cross-sectional structure diagram is shown in figure 2, the real surface structure diagram is shown in figure 8, the electron microscope diagram of the surface structure is shown in figure 5, and the test results are shown in table 1.
As can be seen from FIGS. 1 and 8, the elastic nonwoven material of nano-micro polylactic acid prepared in example 1 of the present invention is composed of 1-1 polylactic acid nano-micro fibers and 1-2 polyolefin elastic filament skeletons, and clear 1-3 brooming holes exist on the surface of the material. It can be known from the combination of fig. 2 and fig. 5 that the 1-1 polylactic acid nano microfiber and the 1-2 polyolefin elastic filament skeleton are interpenetrated to form a stable structure, which provides a basis for the wide range of applicability of the nano-micron polylactic acid elastic nonwoven material.
Example 2
The preparation method of the polylactic acid elastic non-woven material beneficial to tissue regeneration comprises the following steps: the present embodiment is different from embodiment 1 in thatThe average diameter of the polyolefin elastic filament is 180 mu m; meanwhile, the average diameter of the polylactic acid/polycaprolactone nano-micron fiber is 1.8 mu m by increasing the temperature of the melt-blowing die head to 230 ℃. Otherwise, an areal density of 107.8 g/m was obtained in the same manner as in example 12The characteristics of the polylactic acid elastic non-woven material which is beneficial to tissue regeneration are tested and shown in the table 1.
Example 3
The preparation method of the polylactic acid elastic non-woven material beneficial to tissue regeneration comprises the following steps: this example differs from example 1 in that the functional polymer used was polyglycolide, the polyolefin elastic filaments used had an average diameter of 130 μm, and the antibacterial layer used was chitosan/hyaluronic acid as a main component; while increasing the temperature of the melt-blowing die to 230 deg.C, and increasing the fan speed 65r for min-1The average diameter of the polylactic acid/polyglycolide nano-micron fiber is 1.4 mu m. Otherwise, an areal density of 51.6 g/m was obtained in the same manner as in example 12The characteristics of the polylactic acid elastic non-woven material which is beneficial to tissue regeneration are tested and shown in the table 1.
Example 4
The preparation method of the polylactic acid elastic non-woven material beneficial to tissue regeneration comprises the following steps: this example differs from example 1 in that the polyolefin elastic filaments used had an average diameter of 100 μm, and the antibacterial layer used had chitosan/hyaluronic acid as the main component; the integrated process of brooming the holes is a rotary drum (figure 4-B), the rotary drum is characterized by 50 meshes, and the diameter of a water needle plate of the high-pressure water jet is 0.18 mm.
This example employs a drum. As shown in fig. 4-B, the web 4-1 is fed under the nip of the upper drum 4-2-1-2 and the lower drum 4-2-2-2 to the region of the hydroentangling head 4-3, and the high-pressure water jet 4-4 rapidly penetrates the upper drum/web/lower drum and is discharged through the vacuum suction device 4-5; during the period, the high-pressure water jet 4-4 generates regularly distributed broomed holes due to the intermittent obstruction of the upper rotary drum in the process of penetrating the upper rotary drum 4-2-1-2. Except for this, an areal density of 47.8 g/m was obtained in the same manner as in example 12Is favorable to the polylactic acid elastic non-woven material of tissue regenerationThe characteristics of the material are shown in Table 1.
Example 5
The preparation method of the polylactic acid elastic non-woven material beneficial to tissue regeneration comprises the following steps: the difference between this example and example 1 is that the integrated hole-brooming procedure used was a rotary drum (fig. 4-B), the diameter of the water needle plate of the high-pressure water jet was 0.3mm, and the average diameter of the polylactic acid/polyglycolide nano-micro fibers was 2.8 μm by lowering the temperature of the melt-blowing die to 200 ℃. Except for this, an areal density of 36.3 g/m was obtained in the same manner as in example 12The characteristics of the polylactic acid elastic non-woven material which is beneficial to tissue regeneration are tested and shown in the table 1.
Example 6
The preparation method of the polylactic acid elastic non-woven material beneficial to tissue regeneration comprises the following steps: this example differs from example 1 in that polycaprolactone was replaced with polylactide-co-acetic acid; the antibacterial layer of the used polyolefin elastic filament is applied in a coating finishing mode. The integrated structure procedure of the brooming hole is a rotary drum (figure 4-B), and the rotary drum is characterized by 103 meshes. Except for this, a tissue regeneration-facilitating polylactic acid elastic nonwoven material having an areal density of 286 g/m2 was obtained in the same manner as in example 1, and its characteristic test is shown in Table 1.
Example 7
The preparation method of the polylactic acid elastic non-woven material beneficial to tissue regeneration comprises the following steps: the difference between this example and example 1 is that the antibacterial layer of the polyolefin elastic filament is applied by coating finishing, and the integral structure procedure of the brooming holes is characterized by using a screen with 103 meshes. Except for this, a tissue regeneration-facilitating polylactic acid elastic nonwoven material having an areal density of 168.9 g/m2 was obtained in the same manner as in example 1, and its characteristic test is shown in Table 1.
Example 8
The preparation method of the polylactic acid elastic non-woven material beneficial to tissue regeneration comprises the following steps: the difference between the present example and example 1 is that polycaprolactone is replaced by polyethylene glycol-b-polylactic acid, and the main component of the antibacterial layer is chitosan/hyaluronic acid; what is needed isThe screen curtain used in the integrated structure process of brooming holes is characterized by 103 meshes. Except for this, an areal density of 172.6 g/m was obtained in the same manner as in example 12The characteristics of the polylactic acid elastic non-woven material which is beneficial to tissue regeneration are tested and shown in the table 1.
Examples of the effects of the invention
The test method of the invention for the surface density, the thickness, the longitudinal and transverse breaking strength, the longitudinal and transverse breaking elongation, the longitudinal and transverse elastic recovery rate, the bursting strength and the flexibility score is as follows:
areal density
The test method comprises the following steps: the test is carried out by adopting a sample of 50cm2Sampling by a disc sampler, taking five samples, taking the samples to test on a balance, and then averaging.
And (4) testing standard: GBT 24218.1-2009 textile nonwoven test method part 1: and (4) measuring the mass per unit area.
Thickness of
The test method comprises the following steps: selecting 2500cm for the area of the pressure foot according to the test standard2And 50cN is selected as the briquetting. Finally, zero setting, starting testing, pressurizing for 30s, sequentially testing 50 data, and averaging.
And (4) testing standard: GBT 24218.2-2009 textile nonwoven test method part 2: and (4) measuring the thickness.
Testing an instrument: digital fabric thickness gauge (model YG141D, Darong textile instruments Inc., Wenzhou, China).
Longitudinal and transverse rupture strength and rupture elongation test
The test method comprises the following steps: the specification of a sample specified by the national standard is longer than 200mm, the width is 50mm, and the clamping distance is 200mm, but the width of the prepared melt-blown elastic cloth is about 200mm and can not meet the standard requirement due to the limitation of a test prototype. Therefore, the experimental samples are reduced in equal proportion, each sample is divided into 5 blocks in the longitudinal and transverse directions, the sample specification is 120mm long and 20mm wide, the clamping distance is 80mm, the stretching speed is 100mm/min, and the average value is calculated.
And (4) testing standard: GBT 24218.3-2010 textile nonwoven test method part 3: determination of breaking Strength and elongation at Break.
Testing an instrument: wenzhou square and round.
Longitudinal and transverse elastic recovery
The test method comprises the following steps: the test method is the same as the test method for the stretching performance of the elastic polyolefin melt-blown non-woven fabric, and is influenced by the specification of the non-woven sample fabric, the experimental samples are reduced in equal proportion, each sample is 5 pieces in the longitudinal and transverse directions, the specification of the sample is 120mm long and 20mm wide, the clamping distance is 80mm, the stretching speed is 100mm/min, the samples are respectively stretched for 8mm, 24mm and 40mm, the stretching dead time is 60s, the relaxation dead time is 180s, and the samples are repeatedly stretched for two times.
And (4) testing standard: since no nonwoven elasticity standard was found, the test was performed according to the textile fabric standard: FZT 01034-.
Testing an instrument: YG065H fabric electronic strength instrument (YG 065H, Laizhou electronic instruments Co., Ltd., China)
Bursting strength
And (3) testing conditions are as follows: 45mm round sample, the head end of the ejector rod is a polishing steel ball, the diameter of the ball is 25mm, and the bursting speed is 300 mm/min. Each sample was tested for 5 groups and averaged.
And (4) testing standard: GB/T19976-2005 (Steel ball method for measuring bursting strength of textiles)
Testing an instrument: YG065H fabric electronic strength tester (YG 065H, electronics of Laizhou city, Inc., China).
Flexibility score
And (3) testing conditions are as follows:
using an area of 100cm2The disc sampler of (1) cuts 5 pieces of the sample, and the sample is put in a constant temperature and humidity box for humidifying for 24 hours. During the test, all weights are removed, the softness of the sample is tested under the condition of no pressure, and the result is averaged.
And (4) testing standard: AATCC TM 202.
Testing an instrument: PhabrOmeter fabric stylizer (FES-3-10, physical treasure trade limited, shanghai).
The test results were as follows:
TABLE 1 preparation Process parameters and product Properties in examples 1-8
Figure 350308DEST_PATH_IMAGE001
As can be seen from Table 1, the polylactic acid elastic nonwoven material beneficial to tissue regeneration prepared by the method makes full use of the material biodegradation property and the nonwoven structure advantage of polylactic acid. Meanwhile, when the polylactic acid elastic non-woven material which is beneficial to tissue regeneration and is prepared by the method is used as a patch, the unique unidirectional extension elasticity is endowed by the integral structure of the polylactic acid elastic non-woven material; the superfine fiber main body structure and the physical entanglement form endow the superfine fiber with excellent flexibility, and the flexibility score is 30-95 as can be known by a Phabro Ometer test method (AATCC TM 202), and a Phabro Ometer test curve graph is shown in FIG. 6. In addition, as shown in fig. 7, the antibacterial effect diagram of the sample shows that the polylactic acid elastic non-woven material beneficial to tissue regeneration prepared by the invention also has better antibacterial property, is different from the traditional woven structure, is not easy to adhere to the tissue in the viscera repairing process, plays a good separation role, and has the characteristics of good flexibility and no skin irritation in the treatment process.
In conclusion, the polylactic acid elastic non-woven material which is beneficial to tissue regeneration and prepared by the application is an integrated structure with flexibility, elasticity and various pore characteristics, can meet the technical requirements of the polylactic acid elastic non-woven material in the fields of hernia repair, medical dressing, medical bandage and the like, achieves the purposes of promoting wound healing and characteristic treatment, has a wider application range and has better usability.
The invention is supported by national science fund funding projects (52003306), national biomedical material production application demonstration platform funding projects (TC 190H3 ZV/1), school key scientific research projects (20A 540001) such as Henan province high-level and the like, Henan province collaborative innovation center funding projects (2020-CYY-005) of textile and clothing industry, and Henan province medical high polymer material technology and application key laboratories (1-TR-B-03-190227).
The above description is only for the purpose of illustrating the preferred embodiments of the present invention and is not to be construed as limiting the invention, and any modifications, equivalents, improvements and the like that fall within the spirit and principle of the present invention are intended to be included therein.

Claims (9)

1. The preparation method of the polylactic acid elastic non-woven material beneficial to tissue regeneration is characterized by comprising the following steps:
(1) preparation of polyolefin elastic filament framework: taking a polyolefin elastic filament framework as a base material, and performing antibacterial treatment;
(2) preparation of polylactic acid nano microfiber: taking polylactic acid polymer and functional polymer as raw materials, blending, feeding the raw materials into a screw extruder to be softened and melted into blended melt, and then extruding the blended melt through a spinneret orifice to form polylactic acid nano microfiber;
(3) compounding the framework and the fibers: laying the polylactic acid nano microfibers prepared in the step (2) on the polyolefin elastic filament framework treated in the step (1), respectively blowing and holding the polylactic acid nano microfibers to two sides of the polyolefin elastic filament framework by utilizing air flows at the upper side and the lower side and suction air, and compounding and preparing the polylactic acid nano microfibers/polyolefin elastic filament framework/polylactic acid nano microfibers composite material with a nano-micron brooming form by utilizing an ironing and polishing-sanding process; the blanching-sanding process in the step (3) is to tidy a three-layer structure of polylactic acid nano microfiber/polyolefin elastic filament skeleton/polylactic acid nano microfiber into a fiber assembly with a smooth surface by using a single-side blanching process, wherein the sanding process is to tidy the polylactic acid nano microfiber at one side into a velvet structure with the length of 0.1-100 μm;
(4) formation of polylactic acid elastic nonwoven material: and (3) intermittently impacting the side, with the nano-micron brooming form, of the polylactic acid nano microfiber/polyolefin elastic filament framework/polylactic acid nano microfiber composite material prepared in the step (3) by utilizing high-pressure water jet, so that the polylactic acid nano microfiber is flushed and embedded into the polyolefin elastic filament framework to form an integrated structure, and meanwhile, brooming holes are formed in one side by utilizing the cooperation of the high-pressure water jet and a rotary drum/screen curtain, so that the polylactic acid elastic nonwoven material beneficial to tissue regeneration is prepared.
2. The method for preparing polylactic acid elastic non-woven material for tissue regeneration according to claim 1, wherein: the antibacterial treatment in the step (1) is that one or more forms of spraying, coating and dipping are carried out on the surface of the polyolefin elastic filament framework to attach an antibacterial layer with the thickness of 0.01-1 mu m; the antibacterial layer is a bio-based antibacterial material with a degradation period of 40-50 days, and the bio-based antibacterial material is one or a mixture of chitosan and derivatives, hyaluronic acid and derivatives.
3. The method for preparing polylactic acid elastic non-woven material for tissue regeneration according to claim 1, wherein: in the step (2), the solubility ratio of the functional polymer to the polylactic acid polymer is 1 (1.05-10), and the difference of the melting peaks of the functional polymer and the polylactic acid polymer is 0-20 ℃; the functional polymer is in the form of one or more of polycaprolactone, polyglycolide, polylactide-acetic acid copolymer, polycarbon ester, polyethylene glycol-b-polylactic acid and cellulose copolymer.
4. The method for preparing polylactic acid elastic non-woven material for tissue regeneration according to claim 1, wherein: and (3) the air flow and the suction wind on the upper side and the lower side in the step (3) are formed by stacking 2 groups or more than 2 groups of negative pressure fans which are symmetrical left and right and up and down, and the air flow and the suction wind are symmetrically distributed up and down.
5. The method for preparing polylactic acid elastic non-woven material for tissue regeneration according to claim 1, wherein: the high-pressure water jet in the step (4) is characterized in that the initial fineness of the water jet is 0.1mm-0.2 mm; the intermittent barrier is in the form of a regularly moving drum and/or curtain.
6. The method for preparing polylactic acid elastic non-woven material for tissue regeneration according to claim 1, wherein the polylactic acid elastic non-woven material is prepared by a method comprising a step of mixing polylactic acid elastic non-woven material with polylactic acid elastic non-woven materialThe method comprises the following steps: the net curtain in the step (4) is a chemical fiber filament and metal wire laminated cross structure, and is structurally characterized in that: 18-103 mesh, wherein the chemical fiber filament is polyester or polyamide filament, the metal wire is stainless steel and/or nickel, and the surface density of the integrated structure is 15-300g/m2The bulk density is 0.05-0.30 g/m3。
7. A polylactic acid elastic nonwoven material for facilitating tissue regeneration prepared by the method of any one of claims 1 to 6, characterized in that: the polylactic acid elastic non-woven material takes polylactic acid fiber with the average diameter of 0.3-4 mu m as a main body, and one side of the polylactic acid elastic non-woven material consisting of polyolefin elastic filament skeletons with the diameter of 10-200 mu m is provided with an integrated structure of brooming holes; the transverse elongation of the polylactic acid elastic non-woven material is 146-260%, the transverse elastic recovery rate is 75-86%, the longitudinal breaking elongation is 75-135%, and the longitudinal elastic recovery rate is 33-56%; the polylactic acid fiber is characterized in that the number proportion of the included angle between the length direction of the fiber and the longitudinal direction is-20 degrees is 50-80 percent.
8. The polylactic acid elastic nonwoven material according to claim 7, characterized in that: the polyolefin elastic filament backbone is characterized by a roughness of 0.5-50 filaments arranged in a criss-cross pattern with a filament spacing of (0.5-1) cm.
9. The polylactic acid elastic nonwoven material according to claim 7, characterized in that: the brooming hole is characterized in that the area of the opening is 30-60%, and the depth of the opening is 0.01-1 mm.
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