CN104056297A - Polylactic acid-based composite material surgical medical film and preparation method thereof - Google Patents
Polylactic acid-based composite material surgical medical film and preparation method thereof Download PDFInfo
- Publication number
- CN104056297A CN104056297A CN201410273138.9A CN201410273138A CN104056297A CN 104056297 A CN104056297 A CN 104056297A CN 201410273138 A CN201410273138 A CN 201410273138A CN 104056297 A CN104056297 A CN 104056297A
- Authority
- CN
- China
- Prior art keywords
- polylactic acid
- solution
- earth plate
- thin film
- electrospun fibers
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Landscapes
- Spinning Methods And Devices For Manufacturing Artificial Fibers (AREA)
- Artificial Filaments (AREA)
- Medicinal Preparation (AREA)
Abstract
The invention discloses a polylactic acid-based composite material surgical medical film and a preparation method thereof. By adopting electrostatic spinning equipment and exploring proper technological parameters, different types of polylactic acid-based composite material macromolecular fiber thin films are finally formed and are applied to the field of biomedicine. In addition, by regulating and controlling composition of a macromolecular composite material system and thickness of an electro-spinning thin film, the surgical medical film which has good flexibility, high tensile strength, controllable degradation rate as well as excellent waterproof, antibacterial and air permeable performances is obtained finally. The surgical medical film is applicable to the field of various biomedicines such as healing film, wound surface dressing and anti-adhesion medicine; the medical film not only can be better adhered to tissues and avoid biotoxicity, but also can effectively promote transmission functions of blood, nutrients and growth factors in a human body due to the nature of semipermeable membrane. The process of the invention is simple and environment-friendly; the preparation method is easy to operate, low in cost, applicable to large-scale production and good in controllability, and is expected to be widely applied to various medical fields.
Description
Technical field
The present invention relates to field of medical article technology, be specifically related to a kind of polylactic acid-base composite material operation medical films and preparation method thereof.
Background technology
Although modern surgery aseptic technique has had sufficient development, the incidence rate of local infection, complication and second operation post processing in surgical operation is still very high, and becomes the principal element that causes death, extends hospital stays and increase cost.Operation medical film is being brought into play vital effect in surgical operation; it not only can be used as skin recovery film for medical use, wound surface dressing I, II degree burn and the less wound to slight scratch, small size and repairs; when operation the protection of otch and chap, the control of decubital ulcer, can also effectively stop as Antiadhesive film equally the generation of tissue adhesion.It is reported, 50～100% abdominal cavity and operation on pelvis all can cause adhesion in various degree.The sequela that after operation, tissue adhesion brings is: operative site constant pain, postoperative epilepsy, loses partial function, and has increased again the difficulty of operation and the potentiality of generation complication.In surgical operation, how to prevent that tissue adhesion is still one of current important subject both domestic and external.
Operation medical films normally a kind of ultra-thin comfortable semipermeable membrane, has good waterproof, fungi-proofing, ventilative, low sensitization, the feature such as transparent, high-elastic.In clinical practice, have for the preparation of the material of operation medical films at present a variety of, as hyaluronate sodium, chitosan, Polyethylene Glycol etc., but above-mentioned material not only pliability is limited, its controlled degradation is also poor, is unfavorable for practical application.External conventionally using has the object that the polylactic acid-based solid material of absorbing of some strength and shape reaches isolation wound surface and reduces adhesion, but due to higher strength and stiffness, poor pliability and impact resistance, its clinical result of use is also unsatisfactory.International monopoly WO2006/100895 discloses the medical films as forming taking lactide and caprolactone copolymer, it has good flexibility and intensity, but the degradation rate of material itself is slower, completely absorb and need 6 months, likely affect wound healing and tissue repair function.Publication number is that the Chinese patent literature of CN1241442A and CN1305928C is made operation medical film by the blend of the copolymer of polyglycolic acid and polylactic acid, Polyethylene Glycol and polylactic acid respectively, although the introducing of polyglycolic acid and Polyethylene Glycol can be accelerated the vivo degradation speed of polylactic acid, but the purity of thin film is not high and without antiinflammation, thereby limit its wide application in clinical medical field.Publication number is that CN1532216A Chinese patent application discloses polyester and polyethers blend are prepared to medical films, thereby but the polyethers of solubility can be dissolved in body fluid and run off in film in vivo, do not have the effect of fibrocyte at film surface growth that be suppressed to.
In patent of the present invention, polylactic acid is a kind of Biodegradable polymer material, and than other polymer, polylactic acid has excellent mechanical property and good machinability, and its relatively cheap price has also ensured its a large amount of realizability that obtain.Meanwhile, ibuprofen, antibiotic, hyaluronic acid, fibrin and Nano silver grain etc. all belong to bioactive additive, and the introducing of this class additive not only can anti-inflammatory and antalgic, also possess certain adhesion effect in body that prevents.Electrostatic spinning technique has equipment and builds the advantages such as flexible, cheap, easy to operate, has been widely used in bio-medical field.But up to now, by changing compositional system and the related process parameter of polylactic acid-base composite material electrospinning fibre thin film, obtain the operation medical films of excellent combination property, and be widely used in the fields such as wound is compound, anti-tissue adhesion, associated patent was not met report.
Summary of the invention
For solving above-mentioned the deficiencies in the prior art, one of object of the present invention is to provide a kind of polylactic acid-base composite material operation medical films, another object of the present invention is to provide a kind of preparation method of polylactic acid-base composite material operation medical films, adopting process of the present invention is simple, production process is pollution-free and the electrostatic spinning technique of efficient energy-saving, a kind of polylactic acid-base composite material operation medical films and preparation method thereof is provided, this operation medical films not only has excellent hot strength, high resiliency, pliability, be convenient to the maintenance of operation technique and film product integrity, can also effectively prevent wound surface adhesion and reduce the attaching of cell on film surface, hypertrophy and penetrating, at Wound dressing, wound healing and prevent that from there are wide application space and feasibility in the fields such as tissue adhesion.
To achieve these goals, technical scheme of the present invention is:
A kind of polylactic acid-base composite material operation medical films, described medical films adopts polylactic acid-base composite material macromolecular fibre thin film to make, described polylactic acid-base composite material, be preferably polylactic acid/ibuprofen, polylactic acid/hyaluronic acid, polylactic acid/antibiotic, polylactic acid/fibrin, polylactic acid/Nano silver grains etc., wherein polylactic acid viscosity-average molecular weight is 20,000～300,000.
A preparation method for polylactic acid-base composite material operation medical films, comprises the steps:
(1) preparation macromolecule electrospinning solution: polylactic acid-base composite material is dissolved in specific organic solvent, and the concentration of macromolecular solution counted 5～20% with mass fraction to magnetic agitation to obtain uniform solution system in 6～48 hours;
(2) electrostatic spinning: the polymer solution that step (1) is obtained is placed in the feed injector of electrospinning device, the delivery rate of solution is 0.1～5mm/min, the ambient temperature of spinning is set as 20～40 DEG C, open high voltage power supply regulation voltage to 5～25kV, distance between syringe needle point and static earth plate is 5～20cm, finally on static earth plate, obtains electrospun fibers thin film;
(3) collect the fibrous membrane on static earth plate and be placed in baking oven that dry oven temperature is set as 25～50 DEG C to remove organic solvent, be 6～24 hours drying time, until organic solvent weight content is less than 0.01%;
(4), by electrospun fibers thin film sterilization, prepare against as the operation disposable multiple bio-medical field that is used in of medical films.
Further, polylactic acid-base composite material described in step (1), is preferably polylactic acid/ibuprofen, polylactic acid/hyaluronic acid, polylactic acid/antibiotic, polylactic acid/fibrin, polylactic acid/Nano silver grains etc., wherein polylactic acid viscosity-average molecular weight is 20,000～300,000.
Further, described in step (1), specific organic solvent is dichloromethane, chloroform, ethyl acetate, acetone, oxolane, DMF, one or both cosolvent systems in methanol.
Further, the electrospinning device described in step (2) is many spinning heads electrostatic spinning machine, and common-battery spins in process and can increase work efficiency.
Further, in step (2), the thickness of the electrospun fibers thin film of preparation is 0.01～0.5 millimeter.
Further, in step (4), the sterilization method of electrospun fibers film mainly comprises the modes such as ethylene oxide gas sterilizing, ultraviolet rays sterilizing and high steam sterilizing.
Further, electrospun fibers film mainly can be used as skin recovery film for medical use, wound surface dressing and tissue adhesion film and uses in step (4).
Further, when described electrospun fibers thin film uses as tissue adhesion film, main application comprises the adhesion of intraperitoneal intestinal adhesion, liver visceral surface, hepatic portal, hepatoduodenal ligament, the adhesion of pelvic organs, also can be used for preventing the adhesion of dura mater spot and adhesion of tendon after orthopaedics vertebrae plate resection.
With respect to prior art, beneficial effect of the present invention is: the present invention adopts electrostatic spinning technique, prepare the polylactic acid-base composite material electrospun film of different compositional systems and different-thickness, tried hard to obtain the operation medical films of excellent combination property (good pliability, biodegradable, biological activity, good histocompatibility and excellent anti ability).Adopt preparation method of the present invention; technique is simple; preparation means is easy to operate, and cost is low, easily realizes scale; described final products excellent performance; can meet various clinical demands completely, can extensively be used as adherence preventing material in Wound dressing, wound healing film and body, thereby effectively avoid the risk row of postoperative infection, complication and second operation; alleviate patient's misery, improve the quality of living.
Compared with the existing technology, excellent effect of the present invention is embodied in:
(1) the present invention is by changing the composition of polylactic acid-base composite material system, biological activity, hydrophilic, degradation behavior controllability and the good tissue adhesion ability of electrostatic spinning polymer operation medical films are realized, compared with like product comparatively speaking, not only pliability is good for polylactic acid-base composite material operation medical films provided by the invention, degradation time is controlled, and biological activity excellence, has certain bactericidal antiphlogistic effect and anti-tissue adhesion's ability, is beneficial to and is applied in various surgical operations;
(2) Antiadhesive film of the present invention's design comprises different thickness, thereby there are different vivo degradation abilities, wound healing ability and prevent tissue adhesion's effect, by characterizing physics and the biology performance of different-thickness polylactic acid-base composite material operation medical films, finally expand its operating practical application space;
(3) adopt preparation method of the present invention, its equipment requirements and technological process are simple, and cost is low, easily accomplish scale production, and economical and efficient, easy to utilize, final products can meet various clinical demands completely.
Brief description of the drawings
Fig. 1 is the perform the operation preparation flow schematic diagram of medical electrospinning fiber membrane of polylactic acid-base composite material of the present invention.
Detailed description of the invention
Below in conjunction with specific embodiment, the present invention program is described in further detail; be necessary to be pointed out that at this following examples are only for the present invention is further illustrated; can not be interpreted as limiting the scope of the invention, the nonessential improvement that this art skilled person makes the present invention according to the invention described above content and adjustment still belong to protection scope of the present invention.
Embodiment 1:
(1) preparation macromolecule electrospinning solution: polylactic acid/ibuprofen composite is dissolved in dichloromethane, and magnetic agitation 24 hours is to obtain uniform solution system.The concentration of macromolecular solution is 10% (in mass fraction);
(2) electrostatic spinning: the polymer solution that (1) is obtained is placed in the feed injector of electrospinning device, the delivery rate of solution is 0.5mm/min, the ambient temperature of spinning is set as 30 DEG C, open high voltage power supply regulation voltage to 15kV, distance between syringe needle point and static earth plate is 15cm, finally on static earth plate, obtains electrospun fibers thin film;
(3) collect the fibrous membrane on static earth plate and be placed in baking oven that dry oven temperature is set as 40 DEG C to remove organic solvent, be 12 hours drying time, until organic solvent weight content is less than 0.01%;
(4) adopt ethylene oxide gas sterilizing mode by electrospun fibers thin film sterilization, in order to being used in multiple bio-medical field as post-operation adhesion preventing membrane disposable;
Embodiment 2:
(1) preparation macromolecule electrospinning solution: polylactic acid/hyaluronic acid composite is dissolved in dichloromethane, and magnetic agitation 6～48 hours is to obtain uniform solution system.The concentration of macromolecular solution is 5～20% (in mass fractions);
(2) electrostatic spinning: the polymer solution that (1) is obtained is placed in the feed injector of electrospinning device, the delivery rate of solution is 0.5mm/min, the ambient temperature of spinning is set as 30 DEG C, open high voltage power supply regulation voltage to 15kV, distance between syringe needle point and static earth plate is 15cm, finally on static earth plate, obtains electrospun fibers thin film;
(3) collect the fibrous membrane on static earth plate and be placed in baking oven that dry oven temperature is set as 40 DEG C to remove organic solvent, be 12 hours drying time, until organic solvent weight content is less than 0.01%;
(4) adopt ethylene oxide gas sterilizing mode by electrospun fibers thin film sterilization, in order to being used in multiple bio-medical field as post-operation adhesion preventing membrane disposable;
Embodiment 3:
(1) preparation macromolecule electrospinning solution: polylactic acid/antibiotic composite is dissolved in dichloromethane, and magnetic agitation 6～48 hours is to obtain uniform solution system.The concentration of macromolecular solution is 5～20% (in mass fractions);
(2) electrostatic spinning: the polymer solution that (1) is obtained is placed in the feed injector of electrospinning device, the delivery rate of solution is 0.5mm/min, the ambient temperature of spinning is set as 30 DEG C, open high voltage power supply regulation voltage to 15kV, distance between syringe needle point and static earth plate is 15cm, finally on static earth plate, obtains electrospun fibers thin film;
(3) collect the fibrous membrane on static earth plate and be placed in baking oven that dry oven temperature is set as 40 DEG C to remove organic solvent, be 12 hours drying time, until organic solvent weight content is less than 0.01%;
(4) adopt ethylene oxide gas sterilizing mode by electrospun fibers thin film sterilization, in order to being used in multiple bio-medical field as post-operation adhesion preventing membrane disposable;
Embodiment 4:
(1) preparation macromolecule electrospinning solution: polylactic acid/fibrin composite is dissolved in dichloromethane, and magnetic agitation 6～48 hours is to obtain uniform solution system.The concentration of macromolecular solution is 5～20% (in mass fractions);
(2) electrostatic spinning: the polymer solution that (1) is obtained is placed in the feed injector of electrospinning device, the delivery rate of solution is 0.5mm/min, the ambient temperature of spinning is set as 30 DEG C, open high voltage power supply regulation voltage to 15kV, distance between syringe needle point and static earth plate is 15cm, finally on static earth plate, obtains electrospun fibers thin film;
(3) collect the fibrous membrane on static earth plate and be placed in baking oven that dry oven temperature is set as 40 DEG C to remove organic solvent, be 12 hours drying time, until organic solvent weight content is less than 0.01%;
(4) adopt ethylene oxide gas sterilizing mode by electrospun fibers thin film sterilization, in order to being used in multiple bio-medical field as post-operation adhesion preventing membrane disposable;
Embodiment 5:
(1) preparation macromolecule electrospinning solution: polylactic acid/silver nano particle composite material is dissolved in dichloromethane, and magnetic agitation 6～48 hours is to obtain uniform solution system.The concentration of macromolecular solution is 5～20% (in mass fractions);
(2) electrostatic spinning: the polymer solution that (1) is obtained is placed in the feed injector of electrospinning device, the delivery rate of solution is 0.5mm/min, the ambient temperature of spinning is set as 30 DEG C, open high voltage power supply regulation voltage to 15kV, distance between syringe needle point and static earth plate is 15cm, finally on static earth plate, obtains electrospun fibers thin film;
(3) collect the fibrous membrane on static earth plate and be placed in baking oven that dry oven temperature is set as 40 DEG C to remove organic solvent, be 12 hours drying time, until organic solvent weight content is less than 0.01%;
(4) adopt ethylene oxide gas sterilizing mode by electrospun fibers thin film sterilization, in order to being used in multiple bio-medical field as post-operation adhesion preventing membrane disposable;
Embodiment 6:
(1) preparation macromolecule electrospinning solution: polylactic acid/ibuprofen composite is dissolved in chloroform, and magnetic agitation 24 hours is to obtain uniform solution system.The concentration of macromolecular solution is 10% (in mass fraction);
(2) electrostatic spinning: the polymer solution that (1) is obtained is placed in the feed injector of electrospinning device, the delivery rate of solution is 0.5mm/min, the ambient temperature of spinning is set as 30 DEG C, open high voltage power supply regulation voltage to 15kV, distance between syringe needle point and static earth plate is 15cm, finally on static earth plate, obtains electrospun fibers thin film;
(3) collect the fibrous membrane on static earth plate and be placed in baking oven that dry oven temperature is set as 40 DEG C to remove organic solvent, be 12 hours drying time, until organic solvent weight content is less than 0.01%;
(4) adopt ethylene oxide gas sterilizing mode by electrospun fibers thin film sterilization, in order to being used in multiple bio-medical field as post-operation adhesion preventing membrane disposable;
Embodiment 7:
(1) preparation macromolecule electrospinning solution: polylactic acid/ibuprofen composite is dissolved in ethyl acetate, and magnetic agitation 24 hours is to obtain uniform solution system.The concentration of macromolecular solution is 10% (in mass fraction);
(2) electrostatic spinning: the polymer solution that (1) is obtained is placed in the feed injector of electrospinning device, the delivery rate of solution is 0.5mm/min, the ambient temperature of spinning is set as 30 DEG C, open high voltage power supply regulation voltage to 15kV, distance between syringe needle point and static earth plate is 15cm, finally on static earth plate, obtains electrospun fibers thin film;
(3) collect the fibrous membrane on static earth plate and be placed in baking oven that dry oven temperature is set as 40 DEG C to remove organic solvent, be 12 hours drying time, until organic solvent weight content is less than 0.01%;
(4) adopt ethylene oxide gas sterilizing mode by electrospun fibers thin film sterilization, in order to being used in multiple bio-medical field as post-operation adhesion preventing membrane disposable;
Embodiment 8:
(1) preparation macromolecule electrospinning solution: polylactic acid/ibuprofen composite is dissolved in acetone, and magnetic agitation 24 hours is to obtain uniform solution system.The concentration of macromolecular solution is 10% (in mass fraction);
(2) electrostatic spinning: the polymer solution that (1) is obtained is placed in the feed injector of electrospinning device, the delivery rate of solution is 0.5mm/min, the ambient temperature of spinning is set as 30 DEG C, open high voltage power supply regulation voltage to 15kV, distance between syringe needle point and static earth plate is 15cm, finally on static earth plate, obtains electrospun fibers thin film;
(3) collect the fibrous membrane on static earth plate and be placed in baking oven that dry oven temperature is set as 40 DEG C to remove organic solvent, be 12 hours drying time, until organic solvent weight content is less than 0.01%;
(4) adopt ethylene oxide gas sterilizing mode by electrospun fibers thin film sterilization, in order to being used in multiple bio-medical field as post-operation adhesion preventing membrane disposable;
Embodiment 9:
(1) preparation macromolecule electrospinning solution: polylactic acid/ibuprofen composite is dissolved in oxolane, and magnetic agitation 24 hours is to obtain uniform solution system.The concentration of macromolecular solution is 10% (in mass fraction);
(2) electrostatic spinning: the polymer solution that (1) is obtained is placed in the feed injector of electrospinning device, the delivery rate of solution is 0.5mm/min, the ambient temperature of spinning is set as 30 DEG C, open high voltage power supply regulation voltage to 15kV, distance between syringe needle point and static earth plate is 15cm, finally on static earth plate, obtains electrospun fibers thin film;
(3) collect the fibrous membrane on static earth plate and be placed in baking oven that dry oven temperature is set as 40 DEG C to remove organic solvent, be 12 hours drying time, until organic solvent weight content is less than 0.01%;
(4) adopt ethylene oxide gas sterilizing mode by electrospun fibers thin film sterilization, in order to being used in multiple bio-medical field as post-operation adhesion preventing membrane disposable;
Embodiment 10:
(1) preparation macromolecule electrospinning solution: polylactic acid/ibuprofen composite is dissolved in DMF, and magnetic agitation 24 hours is to obtain uniform solution system.The concentration of macromolecular solution is 10% (in mass fraction);
(2) electrostatic spinning: the polymer solution that (1) is obtained is placed in the feed injector of electrospinning device, the delivery rate of solution is 0.5mm/min, the ambient temperature of spinning is set as 30 DEG C, open high voltage power supply regulation voltage to 15kV, distance between syringe needle point and static earth plate is 15cm, finally on static earth plate, obtains electrospun fibers thin film;
(3) collect the fibrous membrane on static earth plate and be placed in baking oven that dry oven temperature is set as 40 DEG C to remove organic solvent, be 12 hours drying time, until organic solvent weight content is less than 0.01%;
(4) adopt ethylene oxide gas sterilizing mode by electrospun fibers thin film sterilization, in order to being used in multiple bio-medical field as post-operation adhesion preventing membrane disposable;
Embodiment 11:
(1) preparation macromolecule electrospinning solution: polylactic acid/ibuprofen composite is dissolved in methanol, and magnetic agitation 24 hours is to obtain uniform solution system.The concentration of macromolecular solution is 10% (in mass fraction);
(2) electrostatic spinning: the polymer solution that (1) is obtained is placed in the feed injector of electrospinning device, the delivery rate of solution is 0.5mm/min, the ambient temperature of spinning is set as 30 DEG C, open high voltage power supply regulation voltage to 15kV, distance between syringe needle point and static earth plate is 15cm, finally on static earth plate, obtains electrospun fibers thin film;
(3) collect the fibrous membrane on static earth plate and be placed in baking oven that dry oven temperature is set as 40 DEG C to remove organic solvent, be 12 hours drying time, until organic solvent weight content is less than 0.01%;
(4) adopt ethylene oxide gas sterilizing mode by electrospun fibers thin film sterilization, in order to being used in multiple bio-medical field as post-operation adhesion preventing membrane disposable;
Embodiment 12:
(1) preparation macromolecule electrospinning solution: polylactic acid/ibuprofen composite is dissolved in dichloromethane, and magnetic agitation 6 hours is to obtain uniform solution system.The concentration of macromolecular solution is 10% (in mass fraction);
(2) electrostatic spinning: the polymer solution that (1) is obtained is placed in the feed injector of electrospinning device, the delivery rate of solution is 0.5mm/min, the ambient temperature of spinning is set as 30 DEG C, open high voltage power supply regulation voltage to 15kV, distance between syringe needle point and static earth plate is 15cm, finally on static earth plate, obtains electrospun fibers thin film;
(3) collect the fibrous membrane on static earth plate and be placed in baking oven that dry oven temperature is set as 40 DEG C to remove organic solvent, be 12 hours drying time, until organic solvent weight content is less than 0.01%;
(4) adopt ethylene oxide gas sterilizing mode by electrospun fibers thin film sterilization, in order to being used in multiple bio-medical field as post-operation adhesion preventing membrane disposable;
Embodiment 13:
(1) preparation macromolecule electrospinning solution: polylactic acid/ibuprofen composite is dissolved in dichloromethane, and magnetic agitation 48 hours is to obtain uniform solution system.The concentration of macromolecular solution is 10% (in mass fraction);
(2) electrostatic spinning: the polymer solution that (1) is obtained is placed in the feed injector of electrospinning device, the delivery rate of solution is 0.5mm/min, the ambient temperature of spinning is set as 30 DEG C, open high voltage power supply regulation voltage to 15kV, distance between syringe needle point and static earth plate is 15cm, finally on static earth plate, obtains electrospun fibers thin film;
(3) collect the fibrous membrane on static earth plate and be placed in baking oven that dry oven temperature is set as 40 DEG C to remove organic solvent, be 12 hours drying time, until organic solvent weight content is less than 0.01%;
(4) adopt ethylene oxide gas sterilizing mode by electrospun fibers thin film sterilization, in order to being used in multiple bio-medical field as post-operation adhesion preventing membrane disposable;
Embodiment 14:
(1) preparation macromolecule electrospinning solution: polylactic acid/ibuprofen composite is dissolved in dichloromethane, and magnetic agitation 24 hours is to obtain uniform solution system.The concentration of macromolecular solution is 5% (in mass fraction);
(2) electrostatic spinning: the polymer solution that (1) is obtained is placed in the feed injector of electrospinning device, the delivery rate of solution is 0.5mm/min, the ambient temperature of spinning is set as 30 DEG C, open high voltage power supply regulation voltage to 15kV, distance between syringe needle point and static earth plate is 15cm, finally on static earth plate, obtains electrospun fibers thin film;
(3) collect the fibrous membrane on static earth plate and be placed in baking oven that dry oven temperature is set as 40 DEG C to remove organic solvent, be 12 hours drying time, until organic solvent weight content is less than 0.01%;
(4) adopt ethylene oxide gas sterilizing mode by electrospun fibers thin film sterilization, in order to being used in multiple bio-medical field as post-operation adhesion preventing membrane disposable;
Embodiment 15:
(1) preparation macromolecule electrospinning solution: polylactic acid/ibuprofen composite is dissolved in dichloromethane, and magnetic agitation 24 hours is to obtain uniform solution system.The concentration of macromolecular solution is 20% (in mass fraction);
(2) electrostatic spinning: the polymer solution that (1) is obtained is placed in the feed injector of electrospinning device, the delivery rate of solution is 0.5mm/min, the ambient temperature of spinning is set as 30 DEG C, open high voltage power supply regulation voltage to 15kV, distance between syringe needle point and static earth plate is 15cm, finally on static earth plate, obtains electrospun fibers thin film;
(3) collect the fibrous membrane on static earth plate and be placed in baking oven that dry oven temperature is set as 40 DEG C to remove organic solvent, be 12 hours drying time, until organic solvent weight content is less than 0.01%;
(4) adopt ethylene oxide gas sterilizing mode by electrospun fibers thin film sterilization, in order to being used in multiple bio-medical field as post-operation adhesion preventing membrane disposable;
Embodiment 16:
(1) preparation macromolecule electrospinning solution: polylactic acid/ibuprofen composite is dissolved in dichloromethane, and magnetic agitation 24 hours is to obtain uniform solution system.The concentration of macromolecular solution is 10% (in mass fraction);
(2) electrostatic spinning: the polymer solution that (1) is obtained is placed in the feed injector of electrospinning device, the delivery rate of solution is 0.1mm/min, the ambient temperature of spinning is set as 30 DEG C, open high voltage power supply regulation voltage to 15kV, distance between syringe needle point and static earth plate is 15cm, finally on static earth plate, obtains electrospun fibers thin film;
(3) collect the fibrous membrane on static earth plate and be placed in baking oven that dry oven temperature is set as 40 DEG C to remove organic solvent, be 12 hours drying time, until organic solvent weight content is less than 0.01%;
(4) adopt ethylene oxide gas sterilizing mode by electrospun fibers thin film sterilization, in order to being used in multiple bio-medical field as post-operation adhesion preventing membrane disposable;
Embodiment 17:
(1) preparation macromolecule electrospinning solution: polylactic acid/ibuprofen composite is dissolved in dichloromethane, and magnetic agitation 24 hours is to obtain uniform solution system.The concentration of macromolecular solution is 10% (in mass fraction);
(2) electrostatic spinning: the polymer solution that (1) is obtained is placed in the feed injector of electrospinning device, the delivery rate of solution is 5mm/min, the ambient temperature of spinning is set as 30 DEG C, open high voltage power supply regulation voltage to 15kV, distance between syringe needle point and static earth plate is 15cm, finally on static earth plate, obtains electrospun fibers thin film;
(3) collect the fibrous membrane on static earth plate and be placed in baking oven that dry oven temperature is set as 40 DEG C to remove organic solvent, be 12 hours drying time, until organic solvent weight content is less than 0.01%;
(4) adopt ethylene oxide gas sterilizing mode by electrospun fibers thin film sterilization, in order to being used in multiple bio-medical field as post-operation adhesion preventing membrane disposable;
Embodiment 18:
(1) preparation macromolecule electrospinning solution: polylactic acid/ibuprofen composite is dissolved in dichloromethane, and magnetic agitation 24 hours is to obtain uniform solution system.The concentration of macromolecular solution is 10% (in mass fraction);
(2) electrostatic spinning: the polymer solution that (1) is obtained is placed in the feed injector of electrospinning device, the delivery rate of solution is 0.5mm/min, the ambient temperature of spinning is set as 20 DEG C, open high voltage power supply regulation voltage to 15kV, distance between syringe needle point and static earth plate is 15cm, finally on static earth plate, obtains electrospun fibers thin film;
(3) collect the fibrous membrane on static earth plate and be placed in baking oven that dry oven temperature is set as 40 DEG C to remove organic solvent, be 12 hours drying time, until organic solvent weight content is less than 0.01%;
(4) adopt ethylene oxide gas sterilizing mode by electrospun fibers thin film sterilization, in order to being used in multiple bio-medical field as post-operation adhesion preventing membrane disposable;
Embodiment 19:
(1) preparation macromolecule electrospinning solution: polylactic acid/ibuprofen composite is dissolved in dichloromethane, and magnetic agitation 24 hours is to obtain uniform solution system.The concentration of macromolecular solution is 10% (in mass fraction);
(2) electrostatic spinning: the polymer solution that (1) is obtained is placed in the feed injector of electrospinning device, the delivery rate of solution is 0.5mm/min, the ambient temperature of spinning is set as 40 DEG C, open high voltage power supply regulation voltage to 15kV, distance between syringe needle point and static earth plate is 15cm, finally on static earth plate, obtains electrospun fibers thin film;
(3) collect the fibrous membrane on static earth plate and be placed in baking oven that dry oven temperature is set as 40 DEG C to remove organic solvent, be 12 hours drying time, until organic solvent weight content is less than 0.01%;
(4) adopt ethylene oxide gas sterilizing mode by electrospun fibers thin film sterilization, in order to being used in multiple bio-medical field as post-operation adhesion preventing membrane disposable;
Embodiment 20:
(1) preparation macromolecule electrospinning solution: polylactic acid/ibuprofen composite is dissolved in dichloromethane, and magnetic agitation 24 hours is to obtain uniform solution system.The concentration of macromolecular solution is 10% (in mass fraction);
(2) electrostatic spinning: the polymer solution that (1) is obtained is placed in the feed injector of electrospinning device, the delivery rate of solution is 0.5mm/min, the ambient temperature of spinning is set as 40 DEG C, open high voltage power supply regulation voltage to 5kV, distance between syringe needle point and static earth plate is 15cm, finally on static earth plate, obtains electrospun fibers thin film;
(3) collect the fibrous membrane on static earth plate and be placed in baking oven that dry oven temperature is set as 40 DEG C to remove organic solvent, be 12 hours drying time, until organic solvent weight content is less than 0.01%;
(4) adopt ethylene oxide gas sterilizing mode by electrospun fibers thin film sterilization, in order to being used in multiple bio-medical field as post-operation adhesion preventing membrane disposable;
Embodiment 21:
(1) preparation macromolecule electrospinning solution: polylactic acid/ibuprofen composite is dissolved in dichloromethane, and magnetic agitation 24 hours is to obtain uniform solution system.The concentration of macromolecular solution is 10% (in mass fraction);
(2) electrostatic spinning: the polymer solution that (1) is obtained is placed in the feed injector of electrospinning device, the delivery rate of solution is 0.5mm/min, the ambient temperature of spinning is set as 40 DEG C, open high voltage power supply regulation voltage to 25kV, distance between syringe needle point and static earth plate is 15cm, finally on static earth plate, obtains electrospun fibers thin film;
(3) collect the fibrous membrane on static earth plate and be placed in baking oven that dry oven temperature is set as 40 DEG C to remove organic solvent, be 12 hours drying time, until organic solvent weight content is less than 0.01%;
(4) adopt ethylene oxide gas sterilizing mode by electrospun fibers thin film sterilization, in order to being used in multiple bio-medical field as post-operation adhesion preventing membrane disposable;
Embodiment 22:
(1) preparation macromolecule electrospinning solution: polylactic acid/ibuprofen composite is dissolved in dichloromethane, and magnetic agitation 24 hours is to obtain uniform solution system.The concentration of macromolecular solution is 10% (in mass fraction);
(2) electrostatic spinning: the polymer solution that (1) is obtained is placed in the feed injector of electrospinning device, the delivery rate of solution is 0.5mm/min, the ambient temperature of spinning is set as 30 DEG C, open high voltage power supply regulation voltage to 15kV, distance between syringe needle point and static earth plate is 5cm, finally on static earth plate, obtains electrospun fibers thin film;
(3) collect the fibrous membrane on static earth plate and be placed in baking oven that dry oven temperature is set as 40 DEG C to remove organic solvent, be 12 hours drying time, until organic solvent weight content is less than 0.01%;
(4) adopt ethylene oxide gas sterilizing mode by electrospun fibers thin film sterilization, in order to being used in multiple bio-medical field as post-operation adhesion preventing membrane disposable;
Embodiment 23:
(1) preparation macromolecule electrospinning solution: polylactic acid/ibuprofen composite is dissolved in dichloromethane, and magnetic agitation 24 hours is to obtain uniform solution system.The concentration of macromolecular solution is 10% (in mass fraction);
(2) electrostatic spinning: the polymer solution that (1) is obtained is placed in the feed injector of electrospinning device, the delivery rate of solution is 0.5mm/min, the ambient temperature of spinning is set as 30 DEG C, open high voltage power supply regulation voltage to 15kV, distance between syringe needle point and static earth plate is 25cm, finally on static earth plate, obtains electrospun fibers thin film;
(3) collect the fibrous membrane on static earth plate and be placed in baking oven that dry oven temperature is set as 40 DEG C to remove organic solvent, be 12 hours drying time, until organic solvent weight content is less than 0.01%;
(4) adopt ethylene oxide gas sterilizing mode by electrospun fibers thin film sterilization, in order to being used in multiple bio-medical field as post-operation adhesion preventing membrane disposable;
Embodiment 24:
(1) preparation macromolecule electrospinning solution: polylactic acid/ibuprofen composite is dissolved in dichloromethane, and magnetic agitation 24 hours is to obtain uniform solution system.The concentration of macromolecular solution is 10% (in mass fraction);
(2) electrostatic spinning: the polymer solution that (1) is obtained is placed in the feed injector of electrospinning device, the delivery rate of solution is 0.5mm/min, the ambient temperature of spinning is set as 30 DEG C, open high voltage power supply regulation voltage to 15kV, distance between syringe needle point and static earth plate is 15cm, finally on static earth plate, obtains electrospun fibers thin film;
(3) collect the fibrous membrane on static earth plate and be placed in baking oven that dry oven temperature is set as 20 DEG C to remove organic solvent, be 12 hours drying time, until organic solvent weight content is less than 0.01%;
(4) adopt ethylene oxide gas sterilizing mode by electrospun fibers thin film sterilization, in order to being used in multiple bio-medical field as post-operation adhesion preventing membrane disposable;
Embodiment 25:
(1) preparation macromolecule electrospinning solution: polylactic acid/ibuprofen composite is dissolved in dichloromethane, and magnetic agitation 24 hours is to obtain uniform solution system.The concentration of macromolecular solution is 10% (in mass fraction);
(2) electrostatic spinning: the polymer solution that (1) is obtained is placed in the feed injector of electrospinning device, the delivery rate of solution is 0.5mm/min, the ambient temperature of spinning is set as 30 DEG C, open high voltage power supply regulation voltage to 15kV, distance between syringe needle point and static earth plate is 15cm, finally on static earth plate, obtains electrospun fibers thin film;
(3) collect the fibrous membrane on static earth plate and be placed in baking oven that dry oven temperature is set as 50 DEG C to remove organic solvent, be 12 hours drying time, until organic solvent weight content is less than 0.01%;
(4) adopt ethylene oxide gas sterilizing mode by electrospun fibers thin film sterilization, in order to being used in multiple bio-medical field as post-operation adhesion preventing membrane disposable;
Embodiment 26:
(1) preparation macromolecule electrospinning solution: polylactic acid/ibuprofen composite is dissolved in dichloromethane, and magnetic agitation 24 hours is to obtain uniform solution system.The concentration of macromolecular solution is 10% (in mass fraction);
(2) electrostatic spinning: the polymer solution that (1) is obtained is placed in the feed injector of electrospinning device, the delivery rate of solution is 0.5mm/min, the ambient temperature of spinning is set as 30 DEG C, open high voltage power supply regulation voltage to 15kV, distance between syringe needle point and static earth plate is 15cm, finally on static earth plate, obtains electrospun fibers thin film;
(3) collect the fibrous membrane on static earth plate and be placed in baking oven that dry oven temperature is set as 40 DEG C to remove organic solvent, be 6 hours drying time, until organic solvent weight content is less than 0.01%;
(4) adopt ethylene oxide gas sterilizing mode by electrospun fibers thin film sterilization, in order to being used in multiple bio-medical field as post-operation adhesion preventing membrane disposable;
Embodiment 27:
(1) preparation macromolecule electrospinning solution: polylactic acid/ibuprofen composite is dissolved in dichloromethane, and magnetic agitation 24 hours is to obtain uniform solution system.The concentration of macromolecular solution is 10% (in mass fraction);
(2) electrostatic spinning: the polymer solution that (1) is obtained is placed in the feed injector of electrospinning device, the delivery rate of solution is 0.5mm/min, the ambient temperature of spinning is set as 30 DEG C, open high voltage power supply regulation voltage to 15kV, distance between syringe needle point and static earth plate is 15cm, finally on static earth plate, obtains electrospun fibers thin film;
(3) collect the fibrous membrane on static earth plate and be placed in baking oven that dry oven temperature is set as 40 DEG C to remove organic solvent, be 24 hours drying time, until organic solvent weight content is less than 0.01%;
(4) adopt ethylene oxide gas sterilizing mode by electrospun fibers thin film sterilization, in order to being used in multiple bio-medical field as post-operation adhesion preventing membrane disposable;
Embodiment 28:
(1) preparation macromolecule electrospinning solution: polylactic acid/ibuprofen composite is dissolved in dichloromethane, and magnetic agitation 24 hours is to obtain uniform solution system.The concentration of macromolecular solution is 10% (in mass fraction);
(2) electrostatic spinning: the polymer solution that (1) is obtained is placed in the feed injector of electrospinning device, the delivery rate of solution is 0.5mm/min, the ambient temperature of spinning is set as 30 DEG C, open high voltage power supply regulation voltage to 15kV, distance between syringe needle point and static earth plate is 15cm, finally on static earth plate, obtains electrospun fibers thin film;
(3) collect the fibrous membrane on static earth plate and be placed in baking oven that dry oven temperature is set as 40 DEG C to remove organic solvent, be 12 hours drying time, until organic solvent weight content is less than 0.01%;
(4) adopt ethylene oxide gas sterilizing mode by electrospun fibers thin film sterilization, in order to being used in multiple bio-medical field as post-operation adhesion preventing membrane disposable;
Embodiment 29:
(1) preparation macromolecule electrospinning solution: polylactic acid/ibuprofen composite is dissolved in dichloromethane, and magnetic agitation 24 hours is to obtain uniform solution system.The concentration of macromolecular solution is 10% (in mass fraction);
(2) electrostatic spinning: the polymer solution that (1) is obtained is placed in the feed injector of electrospinning device, the delivery rate of solution is 0.5mm/min, the ambient temperature of spinning is set as 30 DEG C, open high voltage power supply regulation voltage to 15kV, distance between syringe needle point and static earth plate is 15cm, finally on static earth plate, obtains electrospun fibers thin film;
(3) collect the fibrous membrane on static earth plate and be placed in baking oven that dry oven temperature is set as 40 DEG C to remove organic solvent, be 12 hours drying time, until organic solvent weight content is less than 0.01%;
(4) adopt ultraviolet rays sterilizing mode by electrospun fibers thin film sterilization, in order to being used in multiple bio-medical field as post-operation adhesion preventing membrane disposable;
Embodiment 30:
(1) preparation macromolecule electrospinning solution: polylactic acid/ibuprofen composite is dissolved in dichloromethane, and magnetic agitation 24 hours is to obtain uniform solution system.The concentration of macromolecular solution is 10% (in mass fraction);
(2) electrostatic spinning: the polymer solution that (1) is obtained is placed in the feed injector of electrospinning device, the delivery rate of solution is 0.5mm/min, the ambient temperature of spinning is set as 30 DEG C, open high voltage power supply regulation voltage to 15kV, distance between syringe needle point and static earth plate is 15cm, finally on static earth plate, obtains electrospun fibers thin film;
(3) collect the fibrous membrane on static earth plate and be placed in baking oven that dry oven temperature is set as 40 DEG C to remove organic solvent, be 12 hours drying time, until organic solvent weight content is less than 0.01%;
(4) adopt high steam sterilizing mode by electrospun fibers thin film sterilization, in order to being used in multiple bio-medical field as post-operation adhesion preventing membrane disposable;
Embodiment 31:
(1) preparation macromolecule electrospinning solution: polylactic acid/ibuprofen composite is dissolved in dichloromethane, and magnetic agitation 24 hours is to obtain uniform solution system.The concentration of macromolecular solution is 10% (in mass fraction);
(2) electrostatic spinning: the polymer solution that (1) is obtained is placed in the feed injector of electrospinning device, the delivery rate of solution is 0.5mm/min, the ambient temperature of spinning is set as 30 DEG C, open high voltage power supply regulation voltage to 15kV, distance between syringe needle point and static earth plate is 15cm, finally on static earth plate, obtains electrospun fibers thin film;
(3) collect the fibrous membrane on static earth plate and be placed in baking oven that dry oven temperature is set as 40 DEG C to remove organic solvent, be 12 hours drying time, until organic solvent weight content is less than 0.01%;
(4) adopt ethylene oxide gas sterilizing mode by electrospun fibers thin film sterilization, prepare against as the operation disposable skin recovery film for medical use bio-medical field that is used in of medical films;
Embodiment 32:
(1) preparation macromolecule electrospinning solution: polylactic acid/ibuprofen composite is dissolved in dichloromethane, and magnetic agitation 24 hours is to obtain uniform solution system.The concentration of macromolecular solution is 10% (in mass fraction);
(2) electrostatic spinning: the polymer solution that (1) is obtained is placed in the feed injector of electrospinning device, the delivery rate of solution is 0.5mm/min, the ambient temperature of spinning is set as 30 DEG C, open high voltage power supply regulation voltage to 15kV, distance between syringe needle point and static earth plate is 15cm, finally on static earth plate, obtains electrospun fibers thin film;
(3) collect the fibrous membrane on static earth plate and be placed in baking oven that dry oven temperature is set as 40 DEG C to remove organic solvent, be 12 hours drying time, until organic solvent weight content is less than 0.01%;
(4) adopt ethylene oxide gas sterilizing mode by electrospun fibers thin film sterilization, prepare against as the operation disposable wound surface dressing bio-medical field that is used in of medical films;
Embodiment 33:
(1) preparation macromolecule electrospinning solution: polylactic acid/ibuprofen composite is dissolved in dichloromethane, and magnetic agitation 24 hours is to obtain uniform solution system.The concentration of macromolecular solution is 10% (in mass fraction);
(2) electrostatic spinning: the polymer solution that (1) is obtained is placed in the feed injector of electrospinning device, the delivery rate of solution is 0.5mm/min, the ambient temperature of spinning is set as 30 DEG C, open high voltage power supply regulation voltage to 15kV, distance between syringe needle point and static earth plate is 15cm, finally on static earth plate, obtains electrospun fibers thin film;
(3) collect the fibrous membrane on static earth plate and be placed in baking oven that dry oven temperature is set as 40 DEG C to remove organic solvent, be 12 hours drying time, until organic solvent weight content is less than 0.01%;
(4) adopt ethylene oxide gas sterilizing mode by electrospun fibers thin film sterilization, prepare against as the operation disposable postoperative tissue adhesion film bio-medical field (mainly comprise the adhesion of intraperitoneal intestinal adhesion, liver visceral surface, hepatic portal, hepatoduodenal ligament, the adhesion of pelvic organs, also can be used for preventing the adhesion of dura mater spot and adhesion of tendon etc. after orthopaedics vertebrae plate resection) that is used in of medical films.
The above, be only the specific embodiment of the present invention, but protection scope of the present invention is not limited to this, and any variation of expecting without creative work or replacement, within all should being encompassed in protection scope of the present invention.Therefore, protection scope of the present invention should be as the criterion with the protection domain that claims were limited.
Claims (9)
1. a polylactic acid-base composite material operation medical films, it is characterized in that, described medical films adopts polylactic acid-base composite material macromolecular fibre thin film to make, described polylactic acid-base composite material, is preferably polylactic acid/ibuprofen, polylactic acid/hyaluronic acid, polylactic acid/antibiotic, polylactic acid/fibrin, polylactic acid/Nano silver grain etc., wherein polylactic acid viscosity-average molecular weight is 20,000～300,000.
2. a preparation method for polylactic acid-base composite material operation medical films, is characterized in that, comprises the steps:
(1) preparation macromolecule electrospinning solution: polylactic acid-base composite material is dissolved in specific organic solvent, and the concentration of macromolecular solution counted 5～20% with mass fraction to magnetic agitation to obtain uniform solution system in 6～48 hours;
(2) electrostatic spinning: the polymer solution that step (1) is obtained is placed in the feed injector of electrospinning device, the delivery rate of solution is 0.1～5mm/min, the ambient temperature of spinning is set as 20～40 DEG C, open high voltage power supply regulation voltage to 5～25kV, distance between syringe needle point and static earth plate is 5～20cm, finally on static earth plate, obtains electrospun fibers thin film;
(3) collect the fibrous membrane on static earth plate and be placed in baking oven that dry oven temperature is set as 25～50 DEG C to remove organic solvent, be 6～24 hours drying time, until organic solvent weight content is less than 0.01%;
(4), by electrospun fibers thin film sterilization, prepare against as the operation disposable multiple bio-medical field that is used in of medical films.
3. method according to claim 2, it is characterized in that, polylactic acid-base composite material described in step (1), be preferably polylactic acid/ibuprofen, polylactic acid/hyaluronic acid, polylactic acid/antibiotic, polylactic acid/fibrin, polylactic acid/Nano silver grains etc., wherein polylactic acid viscosity-average molecular weight is 20,000～300,000.
4. method according to claim 2, is characterized in that, described in step (1), specific organic solvent is dichloromethane, chloroform, ethyl acetate, acetone, oxolane, DMF, one or both cosolvent systems in methanol.
5. method according to claim 2, is characterized in that, the electrospinning device described in step (2) is many spinning heads electrostatic spinning machine, and common-battery spins in process and can increase work efficiency.
6. method according to claim 2, is characterized in that, in step (2), the thickness of the electrospun fibers thin film of preparation is 0.01～0.5 millimeter.
7. method according to claim 2, is characterized in that, in step (4), the sterilization method of electrospun fibers film mainly comprises the modes such as ethylene oxide gas sterilizing, ultraviolet rays sterilizing and high steam sterilizing.
8. method according to claim 2, is characterized in that, the middle electrospun fibers film of step (4) mainly can be used as skin recovery film for medical use, wound surface dressing and tissue adhesion film and uses.
9. method according to claim 8, it is characterized in that, when described electrospun fibers thin film uses as tissue adhesion film, main application comprises the adhesion of intraperitoneal intestinal adhesion, liver visceral surface, hepatic portal, hepatoduodenal ligament, the adhesion of pelvic organs, also can be used for preventing the adhesion of dura mater spot and adhesion of tendon after orthopaedics vertebrae plate resection.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410273138.9A CN104056297A (en) | 2014-06-18 | 2014-06-18 | Polylactic acid-based composite material surgical medical film and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410273138.9A CN104056297A (en) | 2014-06-18 | 2014-06-18 | Polylactic acid-based composite material surgical medical film and preparation method thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN104056297A true CN104056297A (en) | 2014-09-24 |
Family
ID=51544410
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201410273138.9A Pending CN104056297A (en) | 2014-06-18 | 2014-06-18 | Polylactic acid-based composite material surgical medical film and preparation method thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN104056297A (en) |
Cited By (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104372437A (en) * | 2014-11-17 | 2015-02-25 | 天津工业大学 | Electrostatic spinning liquid of polylactic acid |
| CN104784744A (en) * | 2015-05-09 | 2015-07-22 | 南京师范大学 | Compound method for preparing wound dressing by utilizing human hair keratin |
| CN105396181A (en) * | 2015-08-24 | 2016-03-16 | 武汉医佳宝生物材料有限公司 | Degradable scaffold medical film preparation method |
| CN105536063A (en) * | 2015-12-17 | 2016-05-04 | 大博医疗科技股份有限公司 | Polylactic acid-based antibacterial slow-release composite coating and preparation method thereof |
| CN105944152A (en) * | 2016-06-13 | 2016-09-21 | 龙岩紫荆创新研究院 | Preparation method of absorbable anti-sticking medical film |
| WO2016202281A1 (en) * | 2015-06-17 | 2016-12-22 | 广州迈普再生医学科技有限公司 | Reinforced electrospun fibrous membrane and preparation method thereof |
| CN106540306A (en) * | 2016-11-24 | 2017-03-29 | 阜阳市汇康医疗器械有限公司 | A kind of aseptic medical cotton stick of efficient moisture-retention |
| CN107441545A (en) * | 2017-08-24 | 2017-12-08 | 陕西科技大学 | A kind of preparation method of skin adherence type nano silver ion antibiotic dressing |
| CN109224116A (en) * | 2018-09-01 | 2019-01-18 | 成都市水泷头化工科技有限公司 | A kind of the antibacterial anti hemorrhagic medical dressing and preparation method of high-absorbable |
| CN112210888A (en) * | 2020-10-23 | 2021-01-12 | 中原工学院 | Polylactic acid elastic non-woven material beneficial to tissue regeneration and preparation method thereof |
| CN112569397A (en) * | 2021-01-08 | 2021-03-30 | 沙洲职业工学院 | Multi-component double-layer composite nano film dressing and production method thereof |
| CN112853605A (en) * | 2021-02-08 | 2021-05-28 | 苏州爱可思医疗科技有限公司 | Completely degradable micro-nano fiber composite material and preparation method thereof |
| CN113026199A (en) * | 2021-03-11 | 2021-06-25 | 北京化工大学 | Component-gradient tendon adhesion-prevention fibrous membrane and preparation method thereof |
| CN113144268A (en) * | 2021-04-23 | 2021-07-23 | 中国人民解放军空军军医大学 | Ozone oil-loaded high-activity nanofiber membrane and preparation method and application thereof |
| CN113304329A (en) * | 2021-05-27 | 2021-08-27 | 北京化工大学 | Iodine-containing antibacterial medical operation film and preparation method thereof |
| CN113862939A (en) * | 2021-09-30 | 2021-12-31 | 海西纺织新材料工业技术晋江研究院 | Cleaning method and cleaning system for human body absorbable medical knitted fabric |
| CN116084058A (en) * | 2023-02-22 | 2023-05-09 | 中山大学·深圳 | Polylactic acid electrostatic spinning fiber with bioadhesion and drug loading function and preparation method thereof |
| CN116531352A (en) * | 2023-07-03 | 2023-08-04 | 北京凯瑞科祺医疗科技有限公司 | Nanofiber membrane for promoting wound healing |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101831762A (en) * | 2010-04-08 | 2010-09-15 | 苏州大学 | Composite fiber porous membrane composited by ornithoctonus huwena threads and polylactic acid and method for producing same |
-
2014
- 2014-06-18 CN CN201410273138.9A patent/CN104056297A/en active Pending
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101831762A (en) * | 2010-04-08 | 2010-09-15 | 苏州大学 | Composite fiber porous membrane composited by ornithoctonus huwena threads and polylactic acid and method for producing same |
Cited By (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104372437A (en) * | 2014-11-17 | 2015-02-25 | 天津工业大学 | Electrostatic spinning liquid of polylactic acid |
| CN104784744A (en) * | 2015-05-09 | 2015-07-22 | 南京师范大学 | Compound method for preparing wound dressing by utilizing human hair keratin |
| WO2016202281A1 (en) * | 2015-06-17 | 2016-12-22 | 广州迈普再生医学科技有限公司 | Reinforced electrospun fibrous membrane and preparation method thereof |
| CN107636220A (en) * | 2015-06-17 | 2018-01-26 | 广州迈普再生医学科技有限公司 | One kind enhancing electrospun fiber membrane and preparation method thereof |
| CN107636220B (en) * | 2015-06-17 | 2019-07-23 | 广州迈普再生医学科技股份有限公司 | A kind of enhancing electrospun fiber membrane and preparation method thereof |
| CN105396181A (en) * | 2015-08-24 | 2016-03-16 | 武汉医佳宝生物材料有限公司 | Degradable scaffold medical film preparation method |
| CN105536063A (en) * | 2015-12-17 | 2016-05-04 | 大博医疗科技股份有限公司 | Polylactic acid-based antibacterial slow-release composite coating and preparation method thereof |
| CN105944152A (en) * | 2016-06-13 | 2016-09-21 | 龙岩紫荆创新研究院 | Preparation method of absorbable anti-sticking medical film |
| CN105944152B (en) * | 2016-06-13 | 2019-02-12 | 龙岩紫荆创新研究院 | The preparation method of absorbable anti-sticking medical film |
| CN106540306A (en) * | 2016-11-24 | 2017-03-29 | 阜阳市汇康医疗器械有限公司 | A kind of aseptic medical cotton stick of efficient moisture-retention |
| CN107441545A (en) * | 2017-08-24 | 2017-12-08 | 陕西科技大学 | A kind of preparation method of skin adherence type nano silver ion antibiotic dressing |
| CN109224116A (en) * | 2018-09-01 | 2019-01-18 | 成都市水泷头化工科技有限公司 | A kind of the antibacterial anti hemorrhagic medical dressing and preparation method of high-absorbable |
| CN112210888A (en) * | 2020-10-23 | 2021-01-12 | 中原工学院 | Polylactic acid elastic non-woven material beneficial to tissue regeneration and preparation method thereof |
| CN112210888B (en) * | 2020-10-23 | 2021-06-25 | 中原工学院 | Polylactic acid elastic non-woven material beneficial to tissue regeneration and preparation method thereof |
| CN112569397A (en) * | 2021-01-08 | 2021-03-30 | 沙洲职业工学院 | Multi-component double-layer composite nano film dressing and production method thereof |
| CN112853605A (en) * | 2021-02-08 | 2021-05-28 | 苏州爱可思医疗科技有限公司 | Completely degradable micro-nano fiber composite material and preparation method thereof |
| CN113026199A (en) * | 2021-03-11 | 2021-06-25 | 北京化工大学 | Component-gradient tendon adhesion-prevention fibrous membrane and preparation method thereof |
| CN113144268A (en) * | 2021-04-23 | 2021-07-23 | 中国人民解放军空军军医大学 | Ozone oil-loaded high-activity nanofiber membrane and preparation method and application thereof |
| CN113304329A (en) * | 2021-05-27 | 2021-08-27 | 北京化工大学 | Iodine-containing antibacterial medical operation film and preparation method thereof |
| CN113304329B (en) * | 2021-05-27 | 2022-04-12 | 北京化工大学 | Iodine-containing antibacterial medical operation film and preparation method thereof |
| CN113862939A (en) * | 2021-09-30 | 2021-12-31 | 海西纺织新材料工业技术晋江研究院 | Cleaning method and cleaning system for human body absorbable medical knitted fabric |
| CN116084058A (en) * | 2023-02-22 | 2023-05-09 | 中山大学·深圳 | Polylactic acid electrostatic spinning fiber with bioadhesion and drug loading function and preparation method thereof |
| CN116531352A (en) * | 2023-07-03 | 2023-08-04 | 北京凯瑞科祺医疗科技有限公司 | Nanofiber membrane for promoting wound healing |
| CN116531352B (en) * | 2023-07-03 | 2023-10-27 | 北京凯瑞科祺医疗科技有限公司 | Nanofiber membrane for promoting wound healing |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN104056297A (en) | Polylactic acid-based composite material surgical medical film and preparation method thereof | |
| Azimi et al. | Bio-based electrospun fibers for wound healing | |
| Rad et al. | Calendula officinalis extract/PCL/Zein/Gum arabic nanofibrous bio-composite scaffolds via suspension, two-nozzle and multilayer electrospinning for skin tissue engineering | |
| Mehrabani et al. | Chitin/silk fibroin/TiO2 bio-nanocomposite as a biocompatible wound dressing bandage with strong antimicrobial activity | |
| Qiu et al. | Bacterial cellulose and bacterial cellulose-vaccarin membranes for wound healing | |
| CN104474589B (en) | A kind of guide tissue regeneration film and the preparation method and application thereof | |
| Wang et al. | Composite electrospun nanomembranes of fish scale collagen peptides/chito-oligosaccharides: antibacterial properties and potential for wound dressing | |
| CN101773689B (en) | Surgical repairing patch | |
| CN102580166A (en) | Medical bionic transparent film implanting material, and preparation method and application of material | |
| CN102921050A (en) | Preparation method of anti-adhesion fibrous membrane with hemostatic function | |
| Wang et al. | Preparation of Centella asiatica loaded gelatin/chitosan/nonwoven fabric composite hydrogel wound dressing with antibacterial property | |
| CN110585474B (en) | Preparation method of marine organism polysaccharide-based composite sponge, composite sponge and application | |
| CN104013995A (en) | Oxidation chitosan graft modified porcine dermal collagen micro-nano fiber membrane and preparation method thereof | |
| Wu et al. | Bio-based electrospun nanofiber of polyhydroxyalkanoate modified with Black Soldier Fly’s pupa shell with antibacterial and cytocompatibility properties | |
| Palanisamy et al. | A critical review on starch-based electrospun nanofibrous scaffolds for wound healing application | |
| CN103120803A (en) | Preparation method of bacterial cellulose composite chitosan moist antimicrobial dressing | |
| CN103768662A (en) | Preparation method of biodegradable medical surgical anti-adhesion membrane | |
| Awasthi et al. | Recent progress in development of dressings used for diabetic wounds with special emphasis on scaffolds | |
| CN103480027A (en) | Preparation method of bacterial cellulose composite chitosan fiber moist dressing | |
| Terzioğlu et al. | Lignin composites for biomedical applications: status, challenges and perspectives | |
| Masek et al. | Technological limitations in obtaining and using cellulose biocomposites | |
| CN109847112A (en) | Enhanced absorbable intraluminal stent of one kind and preparation method thereof | |
| Park et al. | Extracellular Matrix‐Bioinspired Anisotropic Topographical Cues of Electrospun Nanofibers: A Strategy of Wound Healing through Macrophage Polarization | |
| Zhang et al. | Multifunctional xyloglucan-containing electrospun nanofibrous dressings for accelerating infected wound healing | |
| Sadeghianmaryan et al. | Advancements in 3D-printable polysaccharides, proteins, and synthetic polymers for wound dressing and skin scaffolding–A review |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C02 | Deemed withdrawal of patent application after publication (patent law 2001) | ||
| WD01 | Invention patent application deemed withdrawn after publication |
Application publication date: 20140924 |