CN114086319B - Method for reinforcing electro-spinning hernia patch - Google Patents
Method for reinforcing electro-spinning hernia patch Download PDFInfo
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- CN114086319B CN114086319B CN202111394463.7A CN202111394463A CN114086319B CN 114086319 B CN114086319 B CN 114086319B CN 202111394463 A CN202111394463 A CN 202111394463A CN 114086319 B CN114086319 B CN 114086319B
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- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
- A61L31/04—Macromolecular materials
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- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
- A61L31/04—Macromolecular materials
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- A—HUMAN NECESSITIES
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- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
- A61L31/14—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
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- A—HUMAN NECESSITIES
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- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
- A61L31/14—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L31/146—Porous materials, e.g. foams or sponges
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- D04H1/40—Non-woven fabrics formed wholly or mainly of staple fibres or like relatively short fibres from fleeces or layers composed of fibres without existing or potential cohesive properties
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Abstract
The invention belongs to the technical field of application of biomedical materials, and particularly relates to a method for reinforcing an electrospun hernia patch. The fiber structure of the electro-spinning hernia patch is softened and adhered, and the mechanical property of the electro-spinning composite hernia patch is improved under the condition that the porous morphology of the electro-spinning material is maintained. The method has the advantages of simple flow, high controllability, easy operation, good enhancement effect and capability of maintaining the porous structure of the surface of the patch; under the condition of not damaging the fiber structure, the mechanical tensile strength of the patch is improved by more than 200 percent.
Description
Technical Field
The invention belongs to the technical field of application of biomedical materials, and particularly relates to a method for reinforcing an electrospun hernia patch.
Background
In daily life, injury to human tissues or organs is a common disease, which can seriously affect normal life and even threaten life of people, i.e. a part of human tissues or organs leaves the original part and enters another part through gaps, defects or weak parts of the human body. Hernia causes various diseases, and constitutes a serious threat to human health and life. Generally, an adult cannot recover by oneself after suffering from hernia, and must be treated by external means. There are different treatments for hernia. The traditional treatment method comprises hernia band, traditional Chinese medicine therapy, injection sealing, surgery, etc. For adults, surgical treatment is generally employed. The traditional operation is to directly stitch the broken part with a thick seam, and the method has the defects of strong tension suture, severe pain and slow recovery.
The appearance of the hernia patch provides a new thought for treating hernia, but the traditional braided patch has single shape and strong foreign body sensation after being implanted, and the hernia patch prepared by electrostatic spinning can reduce the risks of immune response and tissue calcification; secondly, the thickness, the area and the shape of the product are easier to adjust, so that the clinical requirements are easier to meet; thirdly, the prepared patch has a porous structure, which is beneficial to the growth of cells and promotes healing; finally, the electrostatic spinning technology can fundamentally reduce the production cost, so that the method can be widely applied to primary hospitals. However, the hernia patch prepared by electrospinning has lower mechanical properties, so that the mechanical properties of the hernia patch are improved in a proper way, and the hernia patch is better applied to hernia treatment.
At present, the method for improving the mechanical properties of the electrospun nanofiber membrane mainly comprises the following steps: 1. a polymer blending modification method; 2. solvent bonding improves mechanical process; 3. adding nano particles for blending; 4. a heat treatment process. The comparison of several methods can find that the heat treatment method is more suitable for improving the mechanical properties of the electrostatic spinning composite hernia patch, because the method does not change the composition of the fiber, only changes the physical properties of the polymer, and does not increase the risk of the hernia patch in application. Under normal conditions, when the heat treatment temperature reaches above the glass transition temperature Tg and below the melting temperature Tm of the fiber membrane, the fibers are softened and the polymer chain segments slide, so that effective adhesion can be generated between the fibers, the mechanical property of the patch is improved, the fiber membrane is generally required to be taken down in the existing heating mode, and therefore, the appearance of the fiber membrane is affected, and secondary processing is affected.
Disclosure of Invention
Aiming at the defects of the prior art, the invention provides a method for reinforcing an electrospun hernia patch, and aims to solve the technical problems that the prior heating mode for improving the mechanical property of an electrospun nanofiber membrane generally needs to take down the fiber membrane, the appearance of the fiber membrane can be influenced, and the secondary processing is influenced.
The invention provides a method for reinforcing an electrospun hernia patch, which comprises the following specific technical scheme:
a method for reinforcing an electrospun hernia patch, wherein the electrospun hernia patch is treated by heat radiation generated by an infrared radiant heating device; the electrospun hernia patch is a nanofiber membrane prepared by electrostatic spinning of one or more of polylactic acid-glycolic acid copolymer, poly L-lactide-caprolactone, polylactic acid, polycaprolactone, polyvinylidene fluoride, polybutylene succinate-co-terephthalic acid butylene succinate, polyvinyl alcohol, polypropylene, zein and polyacrylonitrile.
In certain embodiments, the method comprises the steps of:
s1, starting an infrared radiation device, adopting fast medium wave infrared tube irradiation to enable the local space temperature to be higher than the glass transition temperature of the electrospun nanofiber membrane, and obtaining a local high-temperature space below the melting temperature of the electrospun nanofiber membrane;
s2, moving the roller part carrying the electrospun hernia patch into the local high-temperature space in the step S1, and carrying out slow rotation treatment for 10-30S at a speed of 10-40 r/min.
Further, in step S1, the temperature of the local high-temperature space is 40-600 ℃.
Preferably, when the electrospun hernia patch is made of polyvinylidene fluoride material, the temperature of the local high-temperature space is 100-300 ℃.
Preferably, when the electrospun hernia patch is made of polylactic acid-glycolic acid copolymer material, the temperature of the local high temperature space is 50-180 ℃.
Preferably, when the electrospun hernia patch is made of polylactic acid material, the temperature of the local high-temperature space is 70-160 ℃.
Preferably, when the electrospun hernia patch is a polycaprolactone material, the local high temperature space is at a temperature of 40-55deg.C.
Preferably, when the electrospun hernia patch is polybutylene succinate, the temperature of the local high-temperature space is 50-100 ℃.
Further, in step S2, the distance from the roller to the infrared heating device is 2-10cm, and the diameter of the roller is 10-100cm.
In certain embodiments, the infrared radiant device is a single tube fast medium wave infrared tube device, a dual tube infrared tube device, or a multiple tube infrared tube device.
The invention has the following beneficial effects: according to the method for reinforcing the electrospun hernia patch, the electrospun hernia patch is subjected to heat radiation treatment by the infrared radiation heating device, and different temperatures can be set according to different materials, so that the local space temperature is higher than the glass transition temperature Tg and lower than the melting temperature Tm of the materials. Infrared radiation does not need to contact the product nor does it need a transmission medium; the infrared heating pipe can be accurately matched with the heated material, namely, the infrared heating pipe can be effectively absorbed by the material; the response time is quick, and the output heat can be controlled; the material can be heated locally or totally, the heating area can be controlled, and the heating time can be controlled. The general traditional method for heating the high molecular polymer is to heat the surface of the material by means of heat radiation, conduction or convection through hot air by means of the surrounding environment, and then conduct the heat into the material. The method has low efficiency, long heating time, uneven heating and large thermal stress. The infrared auxiliary heat of the fast medium wave has the biggest characteristics that the fast medium wave is generated in the heated object, the heat source is from the inside of the object, the heating is uniform, the phenomenon of clamping of 'outer-coke inner-undercooling' can not be caused, the improvement of the product quality is facilitated, meanwhile, the heating time is greatly shortened due to 'inner-outer simultaneous heating', the heating efficiency is high, and the improvement of the product yield is facilitated. And the heating inertia is very small, so that the rapid control of temperature rise and fall can be realized, and continuous production and automatic control are facilitated. The space temperature enables the surface of the electro-spinning hernia patch to be softened and adhered, and the mechanical property of the electro-spinning composite hernia patch is improved under the condition that the structure is not damaged; under the condition of not damaging the fiber structure, the mechanical tensile strength of the patch is improved by more than 200 percent.
Drawings
FIG. 1 is a scanning electron microscope image of an untreated electrospun hernia patch of example 1;
fig. 2 is a scanning electron microscope image of the electrospun hernia patch treated in example 1 of the present invention.
Detailed Description
The present invention will be further described in detail below with reference to specific embodiments and with reference to fig. 1-2, in order to make the objects, technical solutions and advantages of the present invention more apparent.
The invention provides a method for reinforcing an electrospun hernia patch, which comprises the following specific technical scheme:
a method for reinforcing an electrospun hernia patch, wherein the electrospun hernia patch is treated by heat radiation generated by an infrared radiant heating device; the electrospun hernia patch is a nanofiber membrane prepared by electrostatic spinning of one or more of polylactic acid-glycolic acid copolymer, poly L-lactide-caprolactone, polylactic acid, polycaprolactone, polyvinylidene fluoride, polybutylene succinate-co-terephthalic acid butylene succinate, polyvinyl alcohol, polypropylene, zein and polyacrylonitrile.
The method specifically comprises the following steps:
s1, starting an infrared radiation device to enable the temperature of a local space to reach above the glass transition temperature of the electrospun nanofiber membrane, wherein the temperature of the local space is lower than the melting temperature of the electrospun nanofiber membrane, and a local high-temperature space is obtained;
s2, moving the roller part carrying the electrospun hernia patch into the local high-temperature space in the step S1 to perform slow rotation for 10-40r/min, and processing for 10-30S.
In the step S1, the temperature of the local high-temperature space is 40-600 ℃. In the step S2, the distance from the roller to the infrared heating device is 2-10cm, and the diameter of the roller is 10-100cm.
Preferably, when the electrospun hernia patch is made of polyvinylidene fluoride material, the temperature of the local high-temperature space is 100-300 ℃.
Preferably, when the electrospun hernia patch is made of polylactic acid-glycolic acid copolymer material, the temperature of the local high temperature space is 50-180 ℃.
Preferably, when the electrospun hernia patch is made of polylactic acid material, the temperature of the local high-temperature space is 70-160 ℃.
Preferably, when the electrospun hernia patch is a polycaprolactone material, the local high temperature space is at a temperature of 40-55deg.C.
Preferably, when the electrospun hernia patch is polybutylene succinate, the temperature of the local high-temperature space is 50-100 ℃.
In the invention, the infrared radiation device is a single infrared lamp tube device, a double infrared lamp tube device or a plurality of infrared lamp tube devices.
Example 1
Polyvinylidene fluoride was dissolved in a mixed solvent of N, N-Dimethylformamide (DMF) and acetone (Ace) in a volume ratio of 3:1 to prepare a spinning solution with a mass-volume ratio of 25%. Preparing an electrospun hernia patch by electrospinning and taking a roller as a receiver; setting the temperature of the infrared radiation device to 300 ℃; taking down the obtained electrospun patch belt roller, placing at a distance of 2-5cm from the infrared radiation device, slowly rotating for 10-30s at a speed of 10-40r/min, cooling to room temperature, and taking down the processed electrospun hernia patch. Thus, the patch with high mechanical property is obtained, which is based on infrared radiation heat to cause the surface to be adhered, and the tensile strength is improved by about 300 percent compared with the original patch.
Example 2
Polylactic acid-glycolic acid is copolymerized and dissolved in a mixed solvent of N, N-Dimethylformamide (DMF) and acetone (Ace) in a volume ratio of 1:1 to prepare a spinning solution with a mass-volume ratio of 45%. Preparing an electrospun hernia patch by electrospinning and taking a roller as a receiver; setting the temperature of the infrared radiation device to 160 ℃; taking down the obtained electrospun patch belt roller, placing at a distance of 2-5cm from the infrared radiation device, slowly rotating for 10-30s at a speed of 10-40r/min, cooling to room temperature, and taking down the processed electrospun hernia patch. Thus, the patch with high mechanical property is obtained, which is based on infrared radiation heat to cause the surface to be adhered, and compared with the original patch, the tensile strength is improved by about 400 percent.
In summary, according to the method for reinforcing the electrospun hernia patch provided by the invention, the electrospun hernia patch is subjected to heat radiation treatment by the infrared radiation heating device, and different temperatures and lamp tube wavelengths can be set according to different materials, so that the local space temperature is higher than the glass transition temperature Tg and lower than the melting temperature Tm of the materials. The space temperature enables the surface of the electro-spinning hernia patch to be softened and adhered, and the mechanical property of the electro-spinning composite hernia patch is improved under the condition that the structure is not damaged; under the condition of not damaging the fiber structure, the mechanical tensile strength of the patch is improved by more than 200 percent.
The above preferred embodiments of the present invention are not limited to the above examples, and the present invention is not limited to the above examples, but can be modified, added or replaced by those skilled in the art within the spirit and scope of the present invention.
Claims (9)
1. A method of reinforcing an electrospun hernia patch comprising the steps of:
s1, starting an infrared radiation device, adopting fast medium wave infrared tube irradiation to enable the local space temperature to be higher than the glass transition temperature of an electrospun hernia patch, and obtaining a local high-temperature space below the melting temperature of the electrospun hernia patch;
s2, moving the roller part carrying the electrospun hernia patch into the local high-temperature space in the step S1 for 10-30S by slow rotation treatment of 10-40 r/min;
the electrospun hernia patch is a nanofiber membrane prepared by electrostatic spinning of one or more of polylactic acid-glycolic acid copolymer, poly L-lactide-caprolactone, polylactic acid, polycaprolactone, polyvinylidene fluoride, polybutylene succinate-co-terephthalic acid butylene succinate, polyvinyl alcohol, zein and polyacrylonitrile.
2. The method of reinforcing an electrospun hernia patch according to claim 1, wherein in step S1, the local high temperature space is at a temperature of 40-600 ℃.
3. The method of reinforcing an electrospun hernia patch according to claim 2, wherein the local high temperature space is at a temperature of 100-300 ℃ when the electrospun hernia patch is of polyvinylidene fluoride material.
4. The method of reinforcing an electrospun hernia patch according to claim 2, wherein the local high temperature space is at a temperature of 50-180 ℃ when the electrospun hernia patch is a polylactic acid-glycolic acid copolymer material.
5. The method of reinforcing an electrospun hernia patch according to claim 2, wherein the local high temperature space is at a temperature of 70-160 ℃ when the electrospun hernia patch is a polylactic acid material.
6. A method of reinforcing an electrospun hernia patch according to claim 2, wherein the local high temperature space is at a temperature of 40-55 ℃ when the electrospun hernia patch is of polycaprolactone material.
7. The method of reinforcing an electrospun hernia patch of claim 2, wherein the local high temperature space is at a temperature of 50-100 ℃ when the electrospun hernia patch is polybutylene succinate.
8. A method of reinforcing an electrospun hernia patch according to claim 1, wherein in step S2 the distance of the drum to the infrared thermic devices is 2-10cm and the diameter of the drum is 10-100cm.
9. The method of reinforcing an electrospun hernia patch as recited in claim 1, wherein the infrared radiant device is a single tube fast medium wave infrared tube device, a dual tube infrared tube device or a multi-tube infrared tube device.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202111394463.7A CN114086319B (en) | 2021-11-23 | 2021-11-23 | Method for reinforcing electro-spinning hernia patch |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202111394463.7A CN114086319B (en) | 2021-11-23 | 2021-11-23 | Method for reinforcing electro-spinning hernia patch |
Publications (2)
| Publication Number | Publication Date |
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| CN114086319A CN114086319A (en) | 2022-02-25 |
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