CN104947305A - Hernia repair mesh and preparation method thereof - Google Patents
Hernia repair mesh and preparation method thereof Download PDFInfo
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- CN104947305A CN104947305A CN201410127270.9A CN201410127270A CN104947305A CN 104947305 A CN104947305 A CN 104947305A CN 201410127270 A CN201410127270 A CN 201410127270A CN 104947305 A CN104947305 A CN 104947305A
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- hernia repair
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Abstract
The invention discloses a hernia repair mesh and a preparation method thereof. The hernia repair mesh is in a mesh structure formed by composite weaving of degradable polymer filaments and non-degradable polymer filaments. The degradable polymer filaments are selected from homopolymers or copolymers of one or more of monomers: glycolide, lactide, glycolic acid, lactic acid, caprolactone, dioxanone, trimethylene carbonate and polyhydroxyalkanoate. The non-degradable polymer filaments are made from polypropylene, polyethylene, ethylene-propylene polymers, polyvinylidene fluoride or expanded polytetraflouroethylene. The hernia repair mesh made by composite weaving of the degradable polymer filaments and the non-degradable polymer filaments can keep high mechanical properties after being implanted into a human body for a certain period, and after a patient is completely cured, the degradable portion can be absorbed by the human body gradually, so that in-vivo residues are reduced, and discomfort and relevant symptoms in a later recovery period can be alleviated for the patient.
Description
Technical field
The present invention relates to medical instruments field, particularly a kind of hernia repair sheet and preparation method thereof.
Background technology
Hernia refers to and supports the fracture or reduction that the peritonaeum of internal organs causes due to surgery damage or diseaseization at certain position, and to make in abdomen internal organs by this fracture or weakened location to external outstanding, formation is lump locally.Hernia is a kind of common surgical disease, different according to the position of morbidity, can be divided into indirect inguinal hernia, femoral hernia, umbilical hernia, cuts hernia, spigelian hernia, lumbar hernia etc.Hernia generally can not self-healing, once the displacement projection that organ occurs even can affect patients ' lives safety, therefore needs to treat early.
No-station pole canopy hernia repair surgery is the treating hernia method be most widely used in recent years, and its postoperative recurrence rate is low, operating time is short and wound healing fast, and patient can get back in normal life fast.The eighties in 20th century, the surgeon of the U.S. first proposed employing no-station pole canopy hernia repair surgery to treat hernia, develop into so far, no-station pole canopy hernia repair surgery second, through achieving clinical treatment checking widely, is considered to methods for the treatment of the most safely and effectively.
At present, in clinical, widely used no-station pole canopy is repaired net (hernia net) material and is mainly polyesters (Polyester), polypropylene type (Polypropylene) and expanded polytetrafluoroethylsealing class (ePTFE).Wherein, polypropylene repair mesh is the hernia repair material be most widely used at present, and such as the PerfixPlug of U.S.'s Ahmedabad (Bard) company, the Prolene etc. of Johnson Co. are polypropylene warp-knitted fabric.Polypropylene is repaired net and is had the following advantages: (1) pliability is better; (2) biocompatibility is better; (3) stable chemical nature, not easily by the impact of vivo environment; (4) mechanical property is better, easy cutting; (5) price is relatively cheap etc.
But still there are some problems in current hernia net product, needs further to improve.In operation implementation process, the placement of hernia net and fixingly need it to have certain deflection, affects operation to prevent it from the phenomenons such as curling, displacement occurring in vivo and carries out.Therefore, this just requires that hernia netting gear has certain thickness and intensity, and the pliability of loss part.What adopt due to hernia net is chemically inert substantially, and be implanted to long-term existence after human body, after patient tissue starts healing, hernia net still can maintain its higher deflection.This will cause the stressing conditions at the implant site of patient and other positions of health inconsistent, and patient may feel pain due to illusion, and the foreign body sensation of postoperative some patients or pain condition are comparatively serious.
In order to address these problems, publication number is the preparation research U.S. patents disclosing part degradable hernia net of US4652264 and US6162962, it adopts degradation material and the composite braided physical property realizing hernia net of polypropylene material, guarantee simultaneously later stage degradable part be absorbed by the body after the pliability of surplus material; Publication number be US6287316 U.S. patents disclose a kind of multifilament having degradation material and non-degradable material to form to prepare the method for hernia net.Above-mentioned patent to some extent solves the flexibility problems of later stage material, but because they all adopt multifilament to prepare hernia net, the space in multifilament has the risk of PI bacterium, and therefore these methods also have problems.Publication number is that the Chinese patent of CN1950036A discloses a kind of technology of degradation material and non-degradable material co-blended spinning that adopts to prepare part degradable monofilament, and adopt this monofilament to weave herniae net, The method avoids the defect that multifilament is intrinsic, but co-blended spinning technically also exists larger difficulty, and there is comparatively strict requirement to blended raw material and ratio.In addition, this monofilament is after people's vivo degradation, and uneven palliating degradation degree may appear in the monofilament of non-degradable part, thus occurs defect on the net in hernia, even occurs the mechanical strength of braking effect implant site.Publication number is that the Chinese patent of CN102921044A discloses a kind of method being prepared part degradable hernia paster by degradable function layer and non-degradable supporting layer compound, but the method is prepared mainly through electrostatic spinning, the hernia net mechanical strength obtained is poor, is difficult to tackle complicated pathology.Publication number is that European patent discloses of EP1306061A2 a kind ofly wraps up by degradable mesh sheet the method that non-degradable mesh sheet prepares part degradable hernia net, the method can provide enough mechanical strengths at the implantation initial stage, later stage biodegradable layer is absorbed by the body, thus reduce foreign matter in vivo residual, but it is comparatively complicated that the method prepares hernia net, and the hernia net prepared can not be cut out by doctor, thus limit its application.Publication number be US2013/0012968A1 U.S. patents disclose a kind of degradable hernia net woven by two kinds of degradable monofilament, wherein a kind of degradation rate of monofilament is greater than another kind of monofilament, after a kind of monofilament degraded, the net of another kind of monofilament composition can occur to a certain degree to expand, and then degrades gradually.But the braided structure of the method is comparatively complicated, and mesh aperture is less, the Healing Rate of degradation rate and wound needs coupling in addition, therefore there is certain potential safety hazard.
In sum, although hernia net has been considered to treatment hernia method the most safely and effectively at present, equally also there is postoperative foreign body sensation comparatively strong, the problems such as bacterial infection risk.The aspect such as structural design, mechanical property of existing partly or completely degradable hernia net also has problems.Degradation material has purposes widely in many implanted medical devices, and it can maintain good mechanical property within certain cycle, just can be absorbed by the body subsequently, thus reduces remaining in human body.Therefore, by the compound of degradation material and non-degradable material, adopt special structure to prepare hernia net, it is necessary for improving the existing problem of hernia net.
Summary of the invention
Technical problem to be solved by this invention is to provide a kind of hernia repair sheet and preparation method thereof, hernia repair sheet is made to maintain higher mechanical property in certain hour after implant into body, simultaneously when after patient's healing, wherein degradable part can gradually absorb by human body, residual with what reduce in vivo, alleviate patient and to heal the sense of discomfort in later stage and corresponding illness.
The present invention solves the problems of the technologies described above the technical scheme adopted to be to provide a kind of hernia repair sheet, by degradable polymer monofilament with non-degradable polymer filament is composite braided forms network structure.
Above-mentioned hernia repair sheet, wherein, described degradable polymer monofilament is selected from homopolymers or the copolymer of one or more monomers in following material: glycolide, lactide, glycollic acid, lactic acid, caprolactone, dioxanone, trimethylene carbonate and polyhydroxy-alkanoates.
Above-mentioned hernia repair sheet, wherein, described degradable polymer monofilament is the copolymer of glycolide/lactide, the copolymer of glycolide/caprolactone, the copolymer of lactide/caprolactone or dioxanone homopolymers.
Above-mentioned hernia repair sheet, wherein, the weight percentage of the caprolactone in the lactide in described glycolide/lactide copolymer, the caprolactone in glycolide/caprolactone copolymer or lactide/caprolactone copolymer is 5% to 50%.
Above-mentioned hernia repair sheet, wherein, the weight percentage of the caprolactone in the lactide in described glycolide/lactide copolymer, the caprolactone in glycolide/caprolactone copolymer or lactide/caprolactone copolymer is 5% to 30%.
Above-mentioned hernia repair sheet, wherein, described degradable polymer monofilament comprises band prescription silk and is not with prescription silk.
Above-mentioned hernia repair sheet, wherein, described band prescription silk carries out medicine interpolation by medicine and monofilament coextrusion spin processes or monofilament surface spraying process on monofilament.
Above-mentioned hernia repair sheet, wherein, the antibacterial-anti-inflammatory drug selected by described band prescription silk comprise following one or more: metronidazole, Tinidazole, cefalexin and lavo-ofloxacin.
Above-mentioned hernia repair sheet, wherein, the diameter of described degradable polymer monofilament is 50-150 micron, and ultimate strength is 300-700CN, and elongation at break is 20-100%.
Above-mentioned hernia repair sheet, wherein, the diameter of described degradable polymer monofilament is 90-150 micron. above-mentioned hernia repair sheet, wherein, described non-degradable polymeric monofilament material is polypropylene, polyethylene, ethylene propylene copolymer, polyvinylidene fluoride or expanded polytetrafluoroethylsealing.
Above-mentioned hernia repair sheet, wherein, described non-degradable polymeric monofilament material is polypropylene, ethylene propylene copolymer or expanded polytetrafluoroethylsealing.
Above-mentioned hernia repair sheet, wherein, described non-degradable polymer filament fineness is the 70-150 dawn, and ultimate strength is 500-700CN, and elongation at break is 20-40%.
Above-mentioned hernia repair sheet, wherein, described non-degradable polymer filament fineness is the 90-120 dawn.
Above-mentioned hernia repair sheet, wherein, the volume ratio shared by described degradable polymer monofilament is 20%-60%.
Above-mentioned hernia repair sheet, wherein, the volume ratio shared by described degradable polymer monofilament is 30%-55%.
Above-mentioned hernia repair sheet, wherein, the density of described hernia repair sheet is 4-8/cm, and longitudinal fracture brute force is 30-70N; Lateral density is 3-7/cm, and Cross breaking strength is 30-70N, and thickness is 450-650 μm, and tensile strength is 120-300PSI, and average pore size is 1.0-2.5mm.
Above-mentioned hernia repair sheet, wherein, the density of described hernia repair sheet is 5-7/cm, and longitudinal fracture brute force is 45-70N; Lateral density is 4-6/cm, and Cross breaking strength is 45-70N; Thickness is 500-550 μm, and tensile strength is 120-250PSI, and average pore size is 1.0-2.0mm.
The present invention solves the problems of the technologies described above the preparation method that another technical scheme adopted is to provide a kind of hernia repair sheet, comprises the following steps: 1) described degradable polymer monofilament and non-degradable polymer filament are fed weaving forming on the working needle of different sley bar on warp knitting machine respectively according to preset structure; 2) heat-treated after warp knitting machine takes off by woven fabric, the heat setting temperature of described fabric is 120-150 DEG C, and the time is 1-5 minute.
The preparation method of above-mentioned hernia repair sheet, wherein, warp knitting machine described in described step 1) is tricot warp knitting machine or Raschel looms, and described Raschel looms comprises front comb and rear comb 2 sley bar.
The preparation method of above-mentioned hernia repair sheet, wherein, the structure that described front comb and rear comb adopt is the combination of following a kind of structure or various structures: warp plain stitch, three pin warp plain stitch and satin pin tissue.
The preparation method of above-mentioned hernia repair sheet, wherein, the textural association that described front comb and rear comb adopt is that warp plain stitch and warp plain stitch combine or warp plain stitch and three pin warp plain stitch combine.
The preparation method of above-mentioned hernia repair sheet, wherein, described step 2) in heat setting temperature be 125-135 DEG C, the time is 1-3 minute.
The present invention contrasts prior art following beneficial effect: hernia repair sheet that technical solution of the present invention provides and preparation method thereof, described hernia repair sheet is by degradable polymer monofilament and non-degradable polymer filament is composite braided forms, compared with tradition complete non-degradable hernia net, at the implant into body initial stage, part degradable hernia netting gear has stronger mechanical property the same as non-degradable hernia net, effective treatment hernia, simultaneously after patient's healing, the degradable part of hernia net can be absorbed by the body gradually, thus reduce patient that complete non-degradable hernia net exists more after the discomfort such as pain, compared with other part degradable hernia nets current, degradable part and the non-degradable part of first the present invention's employing are monofilament material, avoid the risk of multifilament PI bacterium, secondly, weaving of the present invention adopts composite braided method, and hernia netting gear has larger mesh aperture, is conducive to passing through of macrophage in human body, thus substantially reduces the possibility of the complication such as infection inflammation.
Accompanying drawing explanation
Fig. 1 is the structural representation of hernia repair sheet in the embodiment of the present invention.
Detailed description of the invention
Below in conjunction with drawings and Examples, the invention will be further described.
Fig. 1 is the structural representation of hernia repair sheet in the embodiment of the present invention.
Refer to Fig. 1, hernia repair sheet provided by the invention is by degradable polymer monofilament and non-degradable polymer filament is composite braided forms network structure, shown in figure, every root lines are all made up of two strands of monofilament, wherein one is degradable polymer monofilament, and namely another stock can be non-degradable polymer filament.Hernia repair sheet has the mechanical property the same with general complete non-degradable hernia repair net at the implant into body initial stage; Meanwhile, along with the healing of patient wound, its degradable part can gradually absorb by human body, final minimizing repairs net in vivo residual, to alleviate the sense of discomfort after patient's postoperation recovery and corresponding illness.
The degradable polymer monofilament used in the present invention is selected from homopolymers or the copolymer of one or more monomers in following material: glycolide, lactide, glycollic acid, lactic acid, caprolactone (6-caprolactone), dioxanone (p-dioxanone), trimethylene carbonate and polyhydroxy-alkanoates.More preferably (in copolymer, lactide mass percentage is 5% to 50% to glycolide/lactide copolymer, be preferably 5% to 30%), (in copolymer, caprolactone mass percentage is 5% to 50% to glycolide/caprolactone copolymer, be preferably 5% to 30%), (in copolymer, caprolactone mass percentage is 5% to 50% to lactide/caprolactone copolymer, be preferably 5% to 30%), dioxanone homopolymers.The degradable polymer monofilament selected comprises band prescription silk and is not with prescription silk two kinds of monofilament.Band prescription silk carries out medicine interpolation by medicine and monofilament coextrusion spin processes or monofilament surface spraying process on monofilament; Antibacterial-anti-inflammatory drug selected by described band prescription silk include but not limited to following one or more: metronidazole, Tinidazole, cefalexin and lavo-ofloxacin.The diameter of described degradable polymer monofilament is 50-150 micron, preferred 90-150 micron, and ultimate strength is 300-700CN, and elongation at break is 20-100%.
The non-degradable polymeric monofilament material used in the present invention is polypropylene, the TPO of polyethylene or ethylene propylene copolymer; The fluoropolymer of polyvinylidene fluoride or expanded polytetrafluoroethylsealing (ePTFE), more preferably polypropylene, ethylene propylene copolymer or expanded polytetrafluoroethylsealing.Its mechanical property is as follows: the monofilament fineness 70-150 dawn, the preferred 90-120 dawn, ultimate strength 500-700CN, and elongation at break is 20-40%.
Hernia repair sheet of the present invention is by biodegradable polymer monofilament and non-degradable polymer filament is composite braided forms, and its physical property is as follows:
Density: 4-8/cm longitudinal fracture is powerful: 30-70N
Lateral density: 3-7/cm Cross breaking strength: 30-70N
Thickness: 450-650 μm tensile strength: 120-300PSI
Average pore size: 1.0-2.5mm
Be more preferably, the physical property of hernia repair sheet of the present invention is as follows:
Density: 5-7/cm longitudinal fracture is powerful: 45-70N
Lateral density: 4-6/cm Cross breaking strength: 45-70N
Thickness: 500-550 μm tensile strength: 120-250PSI
Average pore size: 1.0-2.0mm
Hernia repair sheet provided by the invention is by degradable polymer monofilament and non-degradable polymer filament is composite braided forms, the volume ratio that wherein degradable polymer monofilament accounts for is 20%-60%, particularly preferred, the volume ratio that degradable polymer monofilament accounts for is 30%-55%.Compared with tradition complete non-degradable hernia net, at the implant into body initial stage, hernia repair sheet provided by the invention has stronger mechanical property the same as non-degradable hernia net, effective treatment hernia, simultaneously after patient's healing, the degradable part of hernia net can be absorbed by the body gradually, thus reduce patient that complete non-degradable hernia net exists more after the discomfort such as pain; Compared with other part degradable hernia nets current, degradable part and the non-degradable part of first the present invention's employing are monofilament material, avoid the risk of multifilament PI bacterium; Secondly, weaving of the present invention adopts composite braided method, and hernia netting gear has larger mesh aperture, is conducive to passing through of macrophage in human body, thus substantially reduces the possibility of infection inflammation etc. complication.
The present invention also provides a kind of preparation method of hernia repair sheet, and described preparation method comprises the following steps: raw material-doff-warping-braiding-fabric post processing.
In the present invention, hernia repair sheet can be prepared by tricot warp knitting machine or Raschel looms.In a specific embodiment, degradable polymer monofilament and non-degradable polymer filament feed on the working needle of different sley bar on warp knitting machine according to structural design respectively, form fabric after carrying out lopping.Particularly preferred, the present invention adopts Raschel looms to weave, warp knitting machine comprises 2 sley bars, and the textural association that front comb and rear comb adopt includes but are not limited to the combination of one or more structures following: warp plain stitch, three pin warp plain stitch, satin pin tissue.Be more preferably, the textural association that in the present invention, front comb and rear comb adopt comprises: warp plain stitch and warp plain stitch combine, and warp plain stitch and three pin warp plain stitch combine, and typical fabric construction figure as shown in Figure 1.
The post processing of fabric refers to that fabric is from the heat treatment step after warp knitting machine takes off.In heat-setting process, molecular structure and the arrangement form of fabric fibre change, and strand occurs lax fully, and fabric internal stress is fully discharged thus reaches the less structure of the better internal stress of stability.The heat setting temperature of fabric is 120-150 DEG C, and the time is 1-5 minute.Be more preferably, heat setting temperature of the present invention is 125-135 DEG C, and the time is 1-3 minute.
Monofilament and the braid method of embodiment of the present invention employing are as shown in the table:
Detailed description of the invention is as follows:
Embodiment 1
The raw material of hernia repair sheet non-degradable polymer filament is medical grade polypropylene monofilament, and monofilament fineness was 100 dawn, tensile strength 500-600CN; Degradable polymer monofilament material is medical grade glycolide-caprolactone copolymer (PGCL) monofilament, wherein copolymer quality proportion of composing is glycolide: caprolactone=75:25, filament diameter is 100-150 micron, and warp knitting technology flow process is: raw material-doff-warping-braiding.Degradable polymer monofilament and non-degradable polymer filament are respectively by the working needle weaving forming on front comb and rear comb, and the institutional framework of fabric is as follows:
Front comb: 1-0/1-2//
Rear comb: 1-0/1-2//
Braiding finished product must through HEAT SETTING process, and heat setting temperature is 130 DEG C, and the time is 3 minutes.Final product thickness is 0.55 millimeter, and porosity is greater than 50%, and average pore size is 1.45 millimeters.The physical property of hernia repair sheet (hernia net) is as follows:
Density: 6.2/cm longitudinal fracture is powerful: 60N
Lateral density: 5.2/cm Cross breaking strength: 55N
Thickness: 550 μm of tensile strength: 190PSI
Average pore size: 1.45mm
Embodiment 2
The raw material of hernia repair sheet non-degradable polymer filament is medical grade polypropylene monofilament, and monofilament fineness was 100 dawn, tensile strength 500-600CN; Degradable polymer monofilament is medical grade dioxanone (p-dioxanone) homopolymers (PPDO) monofilament, and filament diameter is 100-150 micron.Warp knitting technology flow process is: raw material-doff-warping-braiding.Degradable polymer monofilament and non-degradable polymer filament are respectively by the working needle weaving forming on front comb and rear comb, and the institutional framework of fabric is as follows:
Front comb: 1-0/1-2//
Rear comb: 1-0/1-2//
Heat setting temperature is 120 DEG C, and the time is 3 minutes.Final product thickness is 0.55 millimeter, and porosity is greater than 50%, and average pore size is 1.45 millimeters.The physical property of hernia net is as follows:
Density: 6.5/cm longitudinal fracture is powerful: 65N
Lateral density: 5.5/cm Cross breaking strength: 58N
Thickness: 550 μm of tensile strength: 190PSI
Average pore size: 1.45mm
Embodiment 3
The raw material of hernia repair sheet non-degradable polymer filament is medical grade polypropylene monofilament, and monofilament fineness was 100 dawn, tensile strength 500-600CN; Degradable polymer monofilament is medical grade glycolide-caprolactone copolymer (PGCL) monofilament, and wherein copolymer weight proportion of composing is glycolide: caprolactone=90:10, and filament diameter is 100-150 micron.Warp knitting technology flow process is: raw material-doff-warping-braiding.Degradable polymer monofilament and non-degradable polymer filament are respectively by the working needle weaving forming on front comb and rear comb, and the institutional framework of fabric is as follows:
Front comb: 1-0/1-2//
Rear comb: 1-0/1-2//
Braiding finished product must through HEAT SETTING process, and heat setting temperature is 130 DEG C, and the time is 3 minutes.Final product thickness is 0.55 millimeter, and porosity is greater than 50%, and average pore size is 1.45 millimeters.The physical property of hernia net is as follows:
Density: 6.0/cm longitudinal fracture is powerful: 58N
Lateral density: 5.0/cm Cross breaking strength: 52N
Thickness: 550 μm of tensile strength: 205PSI
Average pore size: 1.45mm
Embodiment 4
The raw material of hernia repair sheet non-degradable polymer filament is medical grade polypropylene monofilament, and monofilament fineness was 100 dawn, tensile strength 500-600CN; Degradable polymer monofilament is medical grade glycolide-caprolactone copolymer (PGCL) monofilament, wherein copolymer weight proportion of composing is glycolide: caprolactone=75:25, filament diameter is 100-150 micron, and warp knitting technology flow process is: raw material-doff-warping-braiding.Degradable polymer monofilament and non-degradable polymer filament are respectively by the working needle weaving forming on front comb and rear comb, and the institutional framework of fabric is as follows:
Front comb: 1-2/1-0//
Rear comb: 1-0/2-3//
Braiding finished product must through HEAT SETTING process, and heat setting temperature is 130 DEG C, and the time is 3 minutes.Final product thickness is 0.55 millimeter, and porosity is greater than 50%, and average pore size is 1.45 millimeters.The physical property of hernia net is as follows:
Density: 8.0/cm longitudinal fracture is powerful: 65N
Lateral density: 6.8/cm Cross breaking strength: 55N
Thickness: 550 μm of tensile strength: 205PSI
Average pore size: 1.05mm
Embodiment 5
The raw material of hernia repair sheet non-degradable polymer filament is medical grade polypropylene monofilament, and monofilament fineness was 100 dawn, tensile strength 500-600CN; Degradable polymer monofilament is medical grade dioxanone (p-dioxanone) homopolymers (PPDO) monofilament, and filament diameter is 100-150 micron.Warp knitting technology flow process is: raw material-doff-warping-braiding.Degradable polymer monofilament and non-degradable polymer filament are respectively by the working needle weaving forming on front comb and rear comb, and the institutional framework of fabric is as follows:
Front comb: 1-2/1-0//
Rear comb: 1-0/2-3//
Braiding finished product must through HEAT SETTING process, and heat setting temperature is 130 DEG C, and the time is 3 minutes.Final product thickness is 0.55 millimeter, and porosity is greater than 50%, and average pore size is 1.45 millimeters.The physical property of hernia net is as follows:
Density: 8.1/cm longitudinal fracture is powerful: 67N
Lateral density: 6.7/cm Cross breaking strength: 54N
Thickness: 550 μm of tensile strength: 210PSI
Average pore size: 1.12mm
Embodiment 6
The raw material of hernia repair sheet non-degradable polymer filament is medical grade polypropylene monofilament, and monofilament fineness was 100 dawn, tensile strength 500-600CN; Degradable polymer monofilament is medical grade glycolide-caprolactone copolymer (PGCL) monofilament, and wherein copolymer weight proportion of composing is glycolide: caprolactone=90:10, and filament diameter is 100-150 micron.Warp knitting technology flow process is: raw material-doff-warping-braiding.Degradable monofilament and non-degradable monofilament are respectively by the working needle weaving forming on front comb and rear comb, and the institutional framework of fabric is as follows:
Front comb: 1-2/1-0//
Rear comb: 1-0/2-3//
Braiding finished product must through HEAT SETTING process, and heat setting temperature is 130 DEG C, and the time is 3 minutes.Final product thickness is 0.55 millimeter, and porosity is greater than 50%, and average pore size is 1.45 millimeters.The physical property of hernia net is as follows:
Density: 8.0/cm longitudinal fracture is powerful: 68N
Lateral density: 6.4/cm Cross breaking strength: 52N
Thickness: 550 μm of tensile strength: 212PSI
Average pore size: 1.05mm
Embodiment 7
The raw material of hernia repair sheet non-degradable polymer filament is medical grade polypropylene monofilament, and monofilament fineness was 100 dawn, tensile strength 500-600CN; Degradable polymer monofilament is medical grade glycolide-caprolactone copolymer (PGCL) monofilament, wherein copolymer weight proportion of composing is glycolide: caprolactone=75:25, monofilament surface band antibacterials, filament diameter is 100-150 micron, and warp knitting technology flow process is: raw material-doff-warping-braiding.Degradable polymer monofilament and non-degradable polymer filament are respectively by the working needle weaving forming on front comb and rear comb, and the institutional framework of fabric is as follows:
Front comb: 1-0/1-2//
Rear comb: 1-0/1-2//
Braiding finished product must through HEAT SETTING process, and heat setting temperature is 130 DEG C, and the time is 3 minutes.Final product thickness is 0.55 millimeter, and porosity is greater than 50%, and average pore size is 1.45 millimeters.The physical property of hernia net is as follows:
Density: 6.4/cm longitudinal fracture is powerful: 60N
Lateral density: 5.3/cm Cross breaking strength: 55N
Thickness: 550 μm of tensile strength: 188PSI
Average pore size: 1.45mm
Embodiment 8
The raw material of hernia repair sheet non-degradable polymer filament is medical grade polypropylene monofilament, and monofilament fineness was 100 dawn, tensile strength 500-600CN; Degradable polymer monofilament is medical grade dioxanone (p-dioxanone) homopolymers (PPDO) monofilament, monofilament surface band antibacterials, and diameter is 100-150 micron.Warp knitting technology flow process is: raw material-doff-warping-braiding.Degradable polymer monofilament and non-degradable polymer filament are respectively by the working needle weaving forming on front comb and rear comb, and the institutional framework of fabric is as follows:
Front comb: 1-0/1-2//
Rear comb: 1-0/1-2//
Heat setting temperature is 120 DEG C, and the time is 3 minutes.Final product thickness is 0.55 millimeter, and porosity is greater than 50%, and average pore size is 1.45 millimeters.The physical property of hernia net is as follows:
Density: 6.4/cm longitudinal fracture is powerful: 63N
Lateral density: 5.4/cm Cross breaking strength: 55N
Thickness: 550 μm of tensile strength: 185PSI
Average pore size: 1.45mm
Although the present invention discloses as above with preferred embodiment; so itself and be not used to limit the present invention, any those skilled in the art, without departing from the spirit and scope of the present invention; when doing a little amendment and perfect, therefore protection scope of the present invention is when being as the criterion of defining with claims.
Claims (23)
1. a hernia repair sheet, is characterized in that, by degradable polymer monofilament with non-degradable polymer filament is composite braided forms network structure.
2. hernia repair sheet as claimed in claim 1, it is characterized in that, described degradable polymer monofilament is selected from homopolymers or the copolymer of one or more monomers in following material: glycolide, lactide, glycollic acid, lactic acid, caprolactone, dioxanone, trimethylene carbonate and polyhydroxy-alkanoates.
3. hernia repair sheet as claimed in claim 2, is characterized in that, described degradable polymer monofilament is the copolymer of glycolide/lactide, the copolymer of glycolide/caprolactone, the copolymer of lactide/caprolactone or dioxanone homopolymers.
4. hernia repair sheet as claimed in claim 3, it is characterized in that, the weight percentage of the caprolactone in the lactide in described glycolide/lactide copolymer, the caprolactone in glycolide/caprolactone copolymer or lactide/caprolactone copolymer is 5% to 50%.
5. hernia repair sheet as claimed in claim 4, it is characterized in that, the weight percentage of the caprolactone in the lactide in described glycolide/lactide copolymer, the caprolactone in glycolide/caprolactone copolymer or lactide/caprolactone copolymer is 5% to 30%.
6. hernia repair sheet as claimed in claim 1, is characterized in that, described degradable polymer monofilament comprises band prescription silk and is not with prescription silk.
7. hernia repair sheet as claimed in claim 6, is characterized in that, described band prescription silk carries out medicine interpolation by medicine and monofilament coextrusion spin processes or monofilament surface spraying process on monofilament.
8. hernia repair sheet as claimed in claims 6 or 7, is characterized in that, the antibacterial-anti-inflammatory drug selected by described band prescription silk comprise following one or more: metronidazole, Tinidazole, cefalexin and lavo-ofloxacin.
9. hernia repair sheet as claimed in claim 1, it is characterized in that, the diameter of described degradable polymer monofilament is 50-150 micron, and ultimate strength is 300-700CN, and elongation at break is 20-100%.
10. hernia repair sheet as claimed in claim 9, it is characterized in that, the diameter of described degradable polymer monofilament is 90-150 micron.
11. hernia repair sheets as claimed in claim 1, it is characterized in that, described non-degradable polymeric monofilament material is polypropylene, polyethylene, ethylene propylene copolymer, polyvinylidene fluoride or expanded polytetrafluoroethylsealing.
12. hernia repair sheets as claimed in claim 11, it is characterized in that, described non-degradable polymeric monofilament material is polypropylene, ethylene propylene copolymer or expanded polytetrafluoroethylsealing.
13. hernia repair sheets as claimed in claim 1, is characterized in that, described non-degradable polymer filament fineness is the 70-150 dawn, and ultimate strength is 500-700CN, and elongation at break is 20-40%.
14. hernia repair sheets as claimed in claim 13, is characterized in that, described non-degradable polymer filament fineness is the 90-120 dawn.
15. hernia repair sheets as claimed in claim 1, it is characterized in that, the volume ratio shared by described degradable polymer monofilament is 20%-60%.
16. hernia repair sheets as claimed in claim 15, it is characterized in that, the volume ratio shared by described degradable polymer monofilament is 30%-55%.
17. hernia repair sheets as claimed in claim 1, is characterized in that, the density of described hernia repair sheet is 4-8/cm, and longitudinal fracture brute force is 30-70N; Lateral density is 3-7/cm, and Cross breaking strength is 30-70N, and thickness is 450-650 μm, and tensile strength is 120-300PSI, and average pore size is 1.0-2.5mm.
18. hernia repair sheets as claimed in claim 17, is characterized in that, the density of described hernia repair sheet is 5-7/cm, and longitudinal fracture brute force is 45-70N; Lateral density is 4-6/cm, and Cross breaking strength is 45-70N; Thickness is 500-550 μm, and tensile strength is 120-250PSI, and average pore size is 1.0-2.0mm.
The preparation method of the hernia repair sheet described in 19. 1 kinds of any one of claim 1-18, comprises the following steps:
1) described degradable polymer monofilament and non-degradable polymer filament are fed weaving forming on the working needle of different sley bar on warp knitting machine respectively according to preset structure;
2) heat-treated after warp knitting machine takes off by woven fabric, the heat setting temperature of described fabric is 120-150 DEG C, and the time is 1-5 minute.
The preparation method of 20. hernia repair sheets as claimed in claim 19, it is characterized in that, warp knitting machine described in described step 1) is tricot warp knitting machine or Raschel looms, and described Raschel looms comprises front comb and rear comb 2 sley bar.
The preparation method of 21. hernia repair sheets as claimed in claim 20, is characterized in that, the structure that described front comb and rear comb adopt is the combination of following a kind of structure or various structures: warp plain stitch, three pin warp plain stitch and satin pin tissue.
The preparation method of 22. hernia repair sheets as claimed in claim 21, is characterized in that, the textural association that described front comb and rear comb adopt is that warp plain stitch and warp plain stitch combine or warp plain stitch and three pin warp plain stitch combine.
The preparation method of 23. hernia repair sheets as claimed in claim 19, is characterized in that, described step 2) in heat setting temperature be 125-135 DEG C, the time is 1-3 minute.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410127270.9A CN104947305A (en) | 2014-03-31 | 2014-03-31 | Hernia repair mesh and preparation method thereof |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410127270.9A CN104947305A (en) | 2014-03-31 | 2014-03-31 | Hernia repair mesh and preparation method thereof |
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| CN104947305A true CN104947305A (en) | 2015-09-30 |
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| Application Number | Title | Priority Date | Filing Date |
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| CN201410127270.9A Pending CN104947305A (en) | 2014-03-31 | 2014-03-31 | Hernia repair mesh and preparation method thereof |
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| CN108853574A (en) * | 2017-05-10 | 2018-11-23 | 上海交通大学 | Magnesium alloy and kirsite silk material shuffling composite patch and application thereof |
| CN110292461A (en) * | 2019-08-05 | 2019-10-01 | 蚌埠长城医院 | A kind of hernia paster and preparation method thereof |
| CN111821064A (en) * | 2015-11-04 | 2020-10-27 | 聚合-医药有限公司 | Time-dependent tissue scaffolds |
| CN111821521A (en) * | 2020-08-10 | 2020-10-27 | 北京天助畅运医疗技术股份有限公司 | Preparation method of hernia repair patch containing polyvinylidene fluoride |
| CN114246980A (en) * | 2021-12-24 | 2022-03-29 | 无锡中科光远生物材料有限公司 | Partially absorbable hernia repair patch and preparation method thereof |
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Application publication date: 20150930 |