CN104403169A - Medical LDPE(low-density polyethylene) antibacterial material and preparation method thereof - Google Patents
Medical LDPE(low-density polyethylene) antibacterial material and preparation method thereof Download PDFInfo
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- CN104403169A CN104403169A CN201410677984.7A CN201410677984A CN104403169A CN 104403169 A CN104403169 A CN 104403169A CN 201410677984 A CN201410677984 A CN 201410677984A CN 104403169 A CN104403169 A CN 104403169A
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- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
- C08L23/00—Compositions of homopolymers or copolymers of unsaturated aliphatic hydrocarbons having only one carbon-to-carbon double bond; Compositions of derivatives of such polymers
- C08L23/02—Compositions of homopolymers or copolymers of unsaturated aliphatic hydrocarbons having only one carbon-to-carbon double bond; Compositions of derivatives of such polymers not modified by chemical after-treatment
- C08L23/04—Homopolymers or copolymers of ethene
- C08L23/06—Polyethene
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
- B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
- B29C48/00—Extrusion moulding, i.e. expressing the moulding material through a die or nozzle which imparts the desired form; Apparatus therefor
- B29C48/25—Component parts, details or accessories; Auxiliary operations
- B29C48/92—Measuring, controlling or regulating
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
- B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
- B29C2948/00—Indexing scheme relating to extrusion moulding
- B29C2948/92—Measuring, controlling or regulating
- B29C2948/92504—Controlled parameter
- B29C2948/9258—Velocity
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
- B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
- B29C2948/00—Indexing scheme relating to extrusion moulding
- B29C2948/92—Measuring, controlling or regulating
- B29C2948/92504—Controlled parameter
- B29C2948/92704—Temperature
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- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08K—Use of inorganic or non-macromolecular organic substances as compounding ingredients
- C08K2201/00—Specific properties of additives
- C08K2201/011—Nanostructured additives
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- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
- C08L2205/00—Polymer mixtures characterised by other features
- C08L2205/02—Polymer mixtures characterised by other features containing two or more polymers of the same C08L -group
- C08L2205/025—Polymer mixtures characterised by other features containing two or more polymers of the same C08L -group containing two or more polymers of the same hierarchy C08L, and differing only in parameters such as density, comonomer content, molecular weight, structure
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- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
- C08L2205/00—Polymer mixtures characterised by other features
- C08L2205/03—Polymer mixtures characterised by other features containing three or more polymers in a blend
- C08L2205/035—Polymer mixtures characterised by other features containing three or more polymers in a blend containing four or more polymers in a blend
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- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
- C08L2207/00—Properties characterising the ingredient of the composition
- C08L2207/06—Properties of polyethylene
- C08L2207/066—LDPE (radical process)
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Abstract
The application discloses a medical LDPE(low-density polyethylene) antibacterial material and a preparation method thereof. The method comprises the following steps: weighing materials in parts by weight: LDPE, polyethylene wax, an organosilicon quaternary ammonium salt antibacterial agent, CPE(chlorinated polyethylene), nano-magnesium hydroxide, chlorcosane, a fire retardant, dibasic lead phosphite, EVA(ethylene-vinyl acetate), 2, 6-butylated hydroxytoluene, a coupling agent, EAA(ethylene-acrylic acid), zinc borate, stearic acid and an antioxidant 1010, uniformly mixing the materials, and then extruding the mixed materials to make grains so as to obtain the material. The tensile strength of products is 25-45 MPa, the breaking elongation rate is 680-780%; the antibacterial rate to enterobacteria is 99.4-99.8%, and the antibacterial rate to golden staphylococcocci is 99.5-99.9%; the solution flow rate is 2.3-2.8 g/10min, and the surface tension is 4-8*10-4N/m; the right angle tear strength is 105-125 kN/m.
Description
Technical field
The application belongs to medical new material technology field, particularly relates to a kind of medical LDPE anti-biotic material and preparation method thereof.
Background technology
Biomedical material refers to a class and has property, features, for artificial organs, surgical repair, physiotherapy and rehabilitation, diagnosis, treatment illness, and can not produce dysgenic material to tissue.Present various synthetic materials and natural macromolecular material, metal and alloy material, pottery and carbon materials and various matrix material, it is made product and has been widely used in clinical and scientific research.Medical grade silicon rubber (silicone rubber) applies wider biomaterial (tissue substitute) in cosmetic surgery. it is a kind of rubber like solid form of macromolecular organic compound silicone, also known as dimethyl siloxane.Along with development that is biomedical and material, in the biomaterial implantable bone of various artificial preparation, replacement bone is transplanted, clinical application effect is good. the embedded material good biocompatibility of these synthetic or extraction, to bone forming, there is obvious inducing action, are referred to broadly as artificial bone (artificial bone).Generally speaking, clinical medicine has following basic requirement to biomedical material: nontoxicity, not carcinogenic, not teratogenesis, does not cause the sudden change of human body cell and histiocytic reaction; Good with tissue consistency, do not cause poisoning, haemolysis blood coagulation, the phenomenon such as heating and allergy; Stable chemical nature, the effect of antibody liquid, blood and enzyme; There is the physical mechanical characteristic adapted with natural tissues; For different application targets, there is specific function.Biomedical metallic substance (biomedical metallic materials) medical metal material is the metal or alloy as biomedical material, there is very high physical strength and fatigue resistance, be clinical application load embedded material the most widely, mainly contain cobalt-base alloy (co-cr-ni), titanium alloy (ti-6a1-4v) and stainless joint prosthesis and artificial bone.Niti-shaped memorial alloy has the intelligent characteristic of shape memory, can be used in orthopedics, cardiovascular surgery.Biomedical macromolecular material (biomedical polymer) biomedical macromolecular material has natural with synthesis two kinds, and what develop the fastest is synthesis polymer medical material.By molecular designing, the biomaterial much with good physical mechanicalness and biocompatibility can be obtained.The biomedical material that the natural biological tissue that biomedical derived material (biomedical derived materials) bio-derived material is through special processing is formed, treated bio-derived material is the material of lifeless matter vigor, but due to the configuration with similar natural tissues and function, in the reparation and replacement of tissue, there is vital role, main as skin mask, hemodialysis membrane, heart valve prosthesis etc.Biomedical material is widely used, only macromolecular material, and what the whole world was medically applied just has more than 90 kind, more than 1800 to plant goods, the macromolecular material that western countries medically consume every year with 10% ~ 20% speed increment.Along with the important breakthrough of the development especially biotechnology of modern science and technology, the application of biomaterial will be more extensive.Table 1 lists some typically used of bio-medical material, extensively having some idea of of its application.The major impetus that biomedical material is able to fast development is from aging population, the increasing of young and middle-aged wound, the increase of difficult diseases patient and the development of new and high technology.The acceleration of aging population process and the mankind, to the healthy pursuit with longevity, excite the demand to biomaterial.As the country that world population is maximum, China has entered aging country ranks, and the market potential of biomaterial will be huger.The factors such as the change of the quickening of rhythm of life, the expansion of activity space and dietary structure, make wound become a serious social concern.China's wound annual growth of being in hospital reaches 7.2%, is in number of hospitalized the 2nd.U.S.'s treatment cost for bonemuscle system injured patient in 1998 is up to 1,280 hundred million dollars, and only Cranial defect patient just reaches 1,230,000, wherein 80% need treat with biomedical material.In the whole world, the sickness rate such as cardiovascular and cerebrovascular diseases, various cancer, acquired immune deficiency syndrome (AIDS), diabetes, senile dementia increase year by year, are badly in need of the biomaterial for diagnosing, treating and repair.
Medical macromolecular materials are the polymer materialss manufacturing human body viscera, vitro in organ, pharmaceutical dosage form and medicine equipment.Over 20 years, the macromolecular material for this respect has polyvinyl chloride, natural rubber, polyethylene, polymeric amide, polypropylene, polystyrene, silicon rubber, polyester, tetrafluoroethylene, polymethylmethacrylate and urethane etc.Medical macromolecular materials are used for human body, are directly connected to the life and health of people, to the requirement of its performance are generally: 1. security: must be nontoxic or side effect is few.This just requires that polymer purity is high, and production environment is very clean, and remaining of reagent and additive in polymerization is few, and foreign matter content is ppm level, guarantees anosis, nontoxic propagation conditions.2. physics, chemistry and mechanical property: the requirement that need meet medical required Design and Features.As aging in hardness, elasticity, physical strength, fatigue strength, creep, abrasion, water-absorbent, stripping property, resistance to enzymatic and body etc.For heart valve, preferably can use 250,000 hours, require that fatigue resistance is good especially.In addition, also require to be convenient to sterilization, damp and hot sterilization (120 ~ 140 ° of C), dry heat sterilization (160 ~ 190 ° of C), radiation sterilization or chemical treatment sterilization can be tolerated, and do not reduce the performance of material.Require good processability, required different shape can be processed into, and not damage its proper property.3. adaptability: comprise the adaptability with other materials in medical treatment product, the adaptability of material and the various tissue of human body.Medicine equipment, general curative and nurse apparatus, as eye band, casing flusher, entry needle, stethoscope, rectoscope, eye lotion dropper, abdominal belt and connecting piece etc.; Anesthesia and operating room furniture, as suction pump, suture, pharynx mirror, intravascular injection apparatus etc.; Check and inspection chamber apparatus, as the electrode, developmental tube, culture dish etc. of heparin tube, blood collecting bottle, electrocardiogram(ECG.Pharmaceutical dosage form, the auxiliary agent of medicine: macromolecular material itself is inertia, does not participate in the effect of medicine, only plays the effects such as thickening, surfactivity, disintegration, bonding, figuration, lubrication and packaging, or in human body, play " Drug Storage " effect, drug slow is released and prolong drug action time.Polymeric medicine: by low-molecule drug, makes molecular vehicle with inertia water-soluble polymers, the low molecular compound with the property of medicine, is connected, makes polymeric medicine by covalent linkage or ionic linkage with the side base of carrier.
Antibiotic plastic be a class in environment for use itself to stain bacterium on plastics, mould, the female bacterium of alcohol, algae even virus etc. rise and suppress or the plastics of killing action, keep itself clean by suppressing the breeding of microorganism.At present, antibiotic plastic obtains mainly through the method for adding a small amount of antiseptic-germicide in common plastics.First antibiotic plastic will meet the exclusive requirement to performances such as its physics, chemistry, machineries when plastics use as basic material in using, will consider to possess the requirement of this specific function antibacterial and consequent additional factor simultaneously.The research of Chinese medical macromolecular material starts to walk comparatively early, development is very fast.About You50Duo Ge unit is engaged in the research of this respect at present, existing medical macromolecular materials kind more than 60, and goods reach more than 400 and plant, and the polymethylmethacrylate for medical treatment reaches 300 t every year.But the research of Chinese medical macromolecular material is still in experience and semiempirical stage [5] at present, does not also have can be based upon on the basis of molecular designing.Therefore, should with the structure and theory of material, the chemical constitution of material, the pass between surface properties and the consistency of life entity tissue are according to researching and developing novel material.Medical macromolecular materials will be applied to organism must will meet the strict requirement such as biological functionality, biocompatibility, chemical stability and workability simultaneously.
Low Density Polyethylene (LDPE) is a kind of plastic material, and it is applicable to the various moulding processs of thermoplastic molding's processing, and molding processibility is good.LDPE main application makes film product, also for injection-molded item, and medical apparatus, medicine and packaging material for food, blowing slush molding goods etc.Linear low density polyethylene (clorafin), that ethene and a small amount of high alpha-olefin (as butene-1, hexene-1, octene-1, tetramethyl-amylene-1 etc.) are under catalyst action, through a kind of multipolymer of high pressure or low-pressure polymerization, density is between 0.915 ~ 0.940 gram/cc.Usually, LLDPE resin density and melt index characterize.Density is determined by the concentration of comonomer in polymer chain.The concentration of comonomer determines the short-chain branch amount in polymkeric substance.The length of short-chain branch then depends on the type of comonomer.Comonomer concentration is higher, and the density of resin is lower.In addition, melt index is the reflection of resin molecular-weight average, primarily of temperature of reaction (solution method) with add chain-transfer agent (vapor phase process) and decide.Molecular-weight average and molecular weight distribution have nothing to do, and the latter mainly affects by catalyst type.LLDPE by the industrialization of Union Carbide company, it represent the major transformation of polyethylene catalysts and Technology at 20 century 70s, and poly product scope is significantly expanded.LLDPE coordination catalyst replaces radical initiator, and replaces the higher high-pressure reactor of cost with the low-pressure vapor phase polymerization of lower cost, within the shorter time, just with the performance of its excellence and lower cost, instead of LDPE in a lot of fields.LLDPE almost penetrates into all conventional polyethylene market, comprises film, molding, tubing and electric wire.LLDPE product is nontoxic, tasteless, odorless, and be creamy white particle.There is the advantages such as intensity is high, good toughness, rigidity are strong, heat-resisting, cold-resistant compared with LDPE, also there is the performances such as good resisting environmental stress and cracking, tear-resistant intensity, and can acid-and base-resisting, organic solvent etc.2005, Chinese LLDPE output was 1,880,000 tons, accounts for 35.5% of PE ultimate production; Consumption 3,550,000 tons, accounts for 33.8% of PE aggregate consumption.Estimate in following 2 ~ 3 years, the speed of maintenance about 8% continues to increase by LLDPE consumption.According to Vehicles Collected from Market price 12000 yuan/ton calculating, the market scale of Chinese LLDPE has exceeded 40,000,000,000 yuan.And popularizing along with humanity concept, and the formation of novel harmonious society, design high medical LDPE anti-biotic material of a kind of intestinal bacteria antibiotic rate, streptococcus aureus antibiotic rate, tensile strength and elongation at break and preparation method thereof and be very important.
Summary of the invention
the technical problem solved:
The application, for above-mentioned technical problem, provides a kind of medical LDPE anti-biotic material and preparation method thereof, solves the technical problems such as existing medical novel material intestinal bacteria antibiotic rate, streptococcus aureus antibiotic rate, elongation at break and tensile strength are low.
technical scheme:
A kind of medical LDPE anti-biotic material, the raw materials by weight portion proportioning of described medical LDPE anti-biotic material is as follows: LDPE100 part; Polyethylene wax 5-25 part; Silicone Quaternary Ammonium Salt Antimicrobial Agent 1-5 part; CPE40-60 part; Nano-sized magnesium hydroxide 60-80 part; Clorafin 15-35 part; Fire retardant 5-25 part; Dibasic lead phosphite 3-13 part; EVA10-30 part; 2,6 ditertiary butyl p cresol is 0.1-2 part; Coupling agent 2.5-4.5 part; EAA is 6-14 part; Zinc borate 3-5 part; Stearic acid 3-17 part; Antioxidant 1010 is 1-3 part.
As a preferred technical solution of the present invention: the raw materials by weight portion proportioning of described medical LDPE anti-biotic material is as follows: LDPE100 part; Polyethylene wax 10-20 part; Silicone Quaternary Ammonium Salt Antimicrobial Agent 2-4 part; CPE45-55 part; Nano-sized magnesium hydroxide 65-75 part; Clorafin 20-30 part; Fire retardant 10-20 part; Dibasic lead phosphite 6-10 part; EVA15-25 part; 2,6 ditertiary butyl p cresol is 0.5-1.5 part; Coupling agent 3-4 part; EAA is 8-12 part; Zinc borate 3.5-4.5 part; Stearic acid 5-15 part; Antioxidant 1010 is 1.5-2.5 part.
As a preferred technical solution of the present invention: the raw materials by weight portion proportioning of described medical LDPE anti-biotic material is as follows: LDPE100 part; Polyethylene wax 15 parts; Silicone Quaternary Ammonium Salt Antimicrobial Agent 3 parts; CPE50 part; Nano-sized magnesium hydroxide 70 parts; Clorafin 25 parts; Fire retardant 15 parts; Dibasic lead phosphite 8 parts; EVA20 part; 2,6 ditertiary butyl p cresol is 1 part; Coupling agent 3.5 parts; EAA is 10 parts; Zinc borate 4 parts; Stearic acid 10 parts; Antioxidant 1010 is 2 parts.
As a preferred technical solution of the present invention: described fire retardant adopts antimonous oxide or red phosphorus.
As a preferred technical solution of the present invention: described coupling agent adopts silane coupling agent or titanate coupling agent.
As a preferred technical solution of the present invention: the preparation method of described medical LDPE anti-biotic material, comprises the steps:
The first step: take LDPE, polyethylene wax, silicone Quaternary Ammonium Salt Antimicrobial Agent, CPE, nano-sized magnesium hydroxide, clorafin, fire retardant, dibasic lead phosphite, EVA, 2,6 ditertiary butyl p cresol, coupling agent, EAA, zinc borate, stearic acid and antioxidant 1010 according to parts by weight proportioning;
Second step: LDPE, polyethylene wax, silicone Quaternary Ammonium Salt Antimicrobial Agent, CPE and nano-sized magnesium hydroxide are dropped in reactor and is heated to 80-100 DEG C, stirring and drying 2-4h, stirring velocity 300-500 rev/min;
3rd step: then add surplus stock, be warming up to 100-120 DEG C, stirs 20-40min, stirring velocity 400-600 rev/min;
4th step: mixed material is dropped in forcing machine, barrel temperature 140 DEG C, 155 DEG C, 160 DEG C, 175 DEG C, 180 DEG C, 195 DEG C and 205 DEG C, machine head port mould temperature 170-180 DEG C, screw speed 10-60 rev/min, extruding pelletization.
beneficial effect:
One of the present invention medical LDPE anti-biotic material and preparation method thereof adopts above technical scheme compared with prior art, has following technique effect: 1, product tensile strength 10-30MPa, elongation at break 400-600%; 2, intestinal bacteria antibiotic rate 99.5-99.9%, streptococcus aureus antibiotic rate 99.6-99.9%; 3, shore hardness 85, Vicat softening point 105-125 DEG C; 4, winter hardiness-40 degrees Celsius of 3-7d are unchanged, the widespread production not division of history into periods can replace current material.
Embodiment
embodiment 1:
LDPE100 part is taken according to parts by weight proportioning; Polyethylene wax 5 parts; Silicone Quaternary Ammonium Salt Antimicrobial Agent 1 part; CPE40 part; Nano-sized magnesium hydroxide 60 parts; Clorafin 15 parts; 5 parts, red phosphorus; Dibasic lead phosphite 3 parts; EVA10 part; 2,6 ditertiary butyl p cresol is 0.1 part; Titanate coupling agent 2.5 parts; EAA is 6 parts; Zinc borate 3 parts; Stearic acid 3 parts; Antioxidant 1010 is 1 part.
LDPE, polyethylene wax, silicone Quaternary Ammonium Salt Antimicrobial Agent, CPE and nano-sized magnesium hydroxide are dropped in reactor and is heated to 80 DEG C, stirring and drying 2h, stirring velocity 300 revs/min, then surplus stock is added, be warming up to 100 DEG C, stir 20min, stirring velocity 400 revs/min.
Mixed material is dropped in forcing machine, barrel temperature 140 DEG C, 155 DEG C, 160 DEG C, 175 DEG C, 180 DEG C, 195 DEG C and 205 DEG C, machine head port mould temperature 170 DEG C, screw speed 10 revs/min, extruding pelletization.
Product tensile strength 10MPa, elongation at break 400%; Intestinal bacteria antibiotic rate 99.5%, streptococcus aureus antibiotic rate 99.6%; Shore hardness 85, Vicat softening point 105 DEG C;-40 degrees Celsius of 3d are unchanged for winter hardiness.
embodiment 2:
LDPE100 part is taken according to parts by weight proportioning; Polyethylene wax 25 parts; Silicone Quaternary Ammonium Salt Antimicrobial Agent 5 parts; CPE60 part; Nano-sized magnesium hydroxide 80 parts; Clorafin 35 parts; 25 parts, red phosphorus; Dibasic lead phosphite 13 parts; EVA30 part; 2,6 ditertiary butyl p cresol is 2 parts; Titanate coupling agent 4.5 parts; EAA is 14 parts; Zinc borate 5 parts; Stearic acid 17 parts; Antioxidant 1010 is 3 parts.
LDPE, polyethylene wax, silicone Quaternary Ammonium Salt Antimicrobial Agent, CPE and nano-sized magnesium hydroxide are dropped in reactor and is heated to 100 DEG C, stirring and drying 4h, stirring velocity 500 revs/min, then surplus stock is added, be warming up to 120 DEG C, stir 40min, stirring velocity 600 revs/min.
Mixed material is dropped in forcing machine, barrel temperature 140 DEG C, 155 DEG C, 160 DEG C, 175 DEG C, 180 DEG C, 195 DEG C and 205 DEG C, machine head port mould temperature 180 DEG C, screw speed 60 revs/min, extruding pelletization.
Product tensile strength 15MPa, elongation at break 450%; Intestinal bacteria antibiotic rate 99.6%, streptococcus aureus antibiotic rate 99.7%; Shore hardness 85, Vicat softening point 110 DEG C;-40 degrees Celsius of 4d are unchanged for winter hardiness.
embodiment 3:
LDPE100 part is taken according to parts by weight proportioning; Polyethylene wax 10 parts; Silicone Quaternary Ammonium Salt Antimicrobial Agent 2 parts; CPE45 part; Nano-sized magnesium hydroxide 65 parts; Clorafin 20 parts; 10 parts, red phosphorus; Dibasic lead phosphite 6 parts; EVA15 part; 2,6 ditertiary butyl p cresol is 0.5 part; Silane coupling agent 3 parts; EAA is 8 parts; Zinc borate 3.5 parts; Stearic acid 5 parts; Antioxidant 1010 is 1.5 parts.
LDPE, polyethylene wax, silicone Quaternary Ammonium Salt Antimicrobial Agent, CPE and nano-sized magnesium hydroxide are dropped in reactor and is heated to 85 DEG C, stirring and drying 2.5h, stirring velocity 350 revs/min, then surplus stock is added, be warming up to 105 DEG C, stir 25min, stirring velocity 450 revs/min.
Mixed material is dropped in forcing machine, barrel temperature 140 DEG C, 155 DEG C, 160 DEG C, 175 DEG C, 180 DEG C, 195 DEG C and 205 DEG C, machine head port mould temperature 173 DEG C, screw speed 20 revs/min, extruding pelletization.
Product tensile strength 20MPa, elongation at break 500%; Intestinal bacteria antibiotic rate 99.7%, streptococcus aureus antibiotic rate 99.8%; Shore hardness 85, Vicat softening point 115 DEG C;-40 degrees Celsius of 5d are unchanged for winter hardiness.
embodiment 4:
LDPE100 part is taken according to parts by weight proportioning; Polyethylene wax 20 parts; Silicone Quaternary Ammonium Salt Antimicrobial Agent 4 parts; CPE55 part; Nano-sized magnesium hydroxide 75 parts; Clorafin 30 parts; Antimonous oxide 20 parts; Dibasic lead phosphite 10 parts; EVA25 part; 2,6 ditertiary butyl p cresol is 1.5 parts; Silane coupling agent 4 parts; EAA is 12 parts; Zinc borate 4.5 parts; Stearic acid 15 parts; Antioxidant 1010 is 2.5 parts.
LDPE, polyethylene wax, silicone Quaternary Ammonium Salt Antimicrobial Agent, CPE and nano-sized magnesium hydroxide are dropped in reactor and is heated to 95 DEG C, stirring and drying 3.5h, stirring velocity 450 revs/min, then surplus stock is added, be warming up to 115 DEG C, stir 35min, stirring velocity 550 revs/min.
Mixed material is dropped in forcing machine, barrel temperature 140 DEG C, 155 DEG C, 160 DEG C, 175 DEG C, 180 DEG C, 195 DEG C and 205 DEG C, machine head port mould temperature 177 DEG C, screw speed 50 revs/min, extruding pelletization.
Product tensile strength 25MPa, elongation at break 550%; Intestinal bacteria antibiotic rate 99.8%, streptococcus aureus antibiotic rate 99.8%; Shore hardness 85, Vicat softening point 120 DEG C;-40 degrees Celsius of 6d are unchanged for winter hardiness.
embodiment 5:
LDPE100 part is taken according to parts by weight proportioning; Polyethylene wax 15 parts; Silicone Quaternary Ammonium Salt Antimicrobial Agent 3 parts; CPE50 part; Nano-sized magnesium hydroxide 70 parts; Clorafin 25 parts; Antimonous oxide 15 parts; Dibasic lead phosphite 8 parts; EVA20 part; 2,6 ditertiary butyl p cresol is 1 part; Silane coupling agent 3.5 parts; EAA is 10 parts; Zinc borate 4 parts; Stearic acid 10 parts; Antioxidant 1010 is 2 parts.
LDPE, polyethylene wax, silicone Quaternary Ammonium Salt Antimicrobial Agent, CPE and nano-sized magnesium hydroxide are dropped in reactor and is heated to 90 DEG C, stirring and drying 3h, stirring velocity 400 revs/min, then surplus stock is added, be warming up to 110 DEG C, stir 30min, stirring velocity 500 revs/min.
Mixed material is dropped in forcing machine, barrel temperature 140 DEG C, 155 DEG C, 160 DEG C, 175 DEG C, 180 DEG C, 195 DEG C and 205 DEG C, machine head port mould temperature 175 DEG C, screw speed 35 revs/min, extruding pelletization.
Product tensile strength 30MPa, elongation at break 600%; Intestinal bacteria antibiotic rate 99.9%, streptococcus aureus antibiotic rate 99.9%; Shore hardness 85, Vicat softening point 125 DEG C;-40 degrees Celsius of 7d are unchanged for winter hardiness.
Composition all components in above embodiment all can business be bought.
Above-described embodiment is just for setting forth content of the present invention, instead of restriction, and any change therefore in the implication suitable with claims of the present invention and scope, all should think to be included in the scope of claims.
Claims (6)
1. a medical LDPE anti-biotic material, is characterized in that the raw materials by weight portion proportioning of described medical LDPE anti-biotic material is as follows: LDPE100 part; Polyethylene wax 5-25 part; Silicone Quaternary Ammonium Salt Antimicrobial Agent 1-5 part; CPE40-60 part; Nano-sized magnesium hydroxide 60-80 part; Clorafin 15-35 part; Fire retardant 5-25 part; Dibasic lead phosphite 3-13 part; EVA10-30 part; 2,6 ditertiary butyl p cresol is 0.1-2 part; Coupling agent 2.5-4.5 part; EAA is 6-14 part; Zinc borate 3-5 part; Stearic acid 3-17 part; Antioxidant 1010 is 1-3 part.
2. the medical LDPE anti-biotic material of one according to claim 1, is characterized in that described medical LDPE anti-biotic material raw materials by weight portion proportioning is as follows: LDPE100 part; Polyethylene wax 10-20 part; Silicone Quaternary Ammonium Salt Antimicrobial Agent 2-4 part; CPE45-55 part; Nano-sized magnesium hydroxide 65-75 part; Clorafin 20-30 part; Fire retardant 10-20 part; Dibasic lead phosphite 6-10 part; EVA15-25 part; 2,6 ditertiary butyl p cresol is 0.5-1.5 part; Coupling agent 3-4 part; EAA is 8-12 part; Zinc borate 3.5-4.5 part; Stearic acid 5-15 part; Antioxidant 1010 is 1.5-2.5 part.
3. the medical LDPE anti-biotic material of one according to claim 1, is characterized in that the raw materials by weight portion proportioning of described medical LDPE anti-biotic material is as follows: LDPE100 part; Polyethylene wax 15 parts; Silicone Quaternary Ammonium Salt Antimicrobial Agent 3 parts; CPE50 part; Nano-sized magnesium hydroxide 70 parts; Clorafin 25 parts; Fire retardant 15 parts; Dibasic lead phosphite 8 parts; EVA20 part; 2,6 ditertiary butyl p cresol is 1 part; Coupling agent 3.5 parts; EAA is 10 parts; Zinc borate 4 parts; Stearic acid 10 parts; Antioxidant 1010 is 2 parts.
4. the medical LDPE anti-biotic material of one according to claim 1, is characterized in that: described fire retardant adopts antimonous oxide or red phosphorus.
5. the medical LDPE anti-biotic material of one according to claim 1, is characterized in that: described coupling agent adopts silane coupling agent or titanate coupling agent.
6. a preparation method for medical LDPE anti-biotic material described in claim 1, is characterized in that, comprise the steps:
The first step: take LDPE, polyethylene wax, silicone Quaternary Ammonium Salt Antimicrobial Agent, CPE, nano-sized magnesium hydroxide, clorafin, fire retardant, dibasic lead phosphite, EVA, 2,6 ditertiary butyl p cresol, coupling agent, EAA, zinc borate, stearic acid and antioxidant 1010 according to parts by weight proportioning;
Second step: LDPE, polyethylene wax, silicone Quaternary Ammonium Salt Antimicrobial Agent, CPE and nano-sized magnesium hydroxide are dropped in reactor and is heated to 80-100 DEG C, stirring and drying 2-4h, stirring velocity 300-500 rev/min;
3rd step: then add surplus stock, be warming up to 100-120 DEG C, stirs 20-40min, stirring velocity 400-600 rev/min;
4th step: mixed material is dropped in forcing machine, barrel temperature 140 DEG C, 155 DEG C, 160 DEG C, 175 DEG C, 180 DEG C, 195 DEG C and 205 DEG C, machine head port mould temperature 170-180 DEG C, screw speed 10-60 rev/min, extruding pelletization.
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Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105754178A (en) * | 2016-03-01 | 2016-07-13 | 苏州市贝克生物科技有限公司 | Composite material for transfusion bag and preparation method of composite material |
| CN106800767A (en) * | 2016-06-17 | 2017-06-06 | 无锡英普林纳米科技有限公司 | A kind of high intensity anti-biotic material for nano-imprinting apparatus |
| CN107334653A (en) * | 2017-07-12 | 2017-11-10 | 南雄鼎成新材料科技有限公司 | A kind of antibacterial anti-dandruff and itching-relieving shampoo with treatment containing organosilicon quaternary ammonium salt |
| CN112940958A (en) * | 2020-12-02 | 2021-06-11 | 浙大宁波理工学院 | Strain capable of effectively degrading short-chain chlorinated paraffin, and rapid screening method and application thereof |
| CN117229584A (en) * | 2023-11-10 | 2023-12-15 | 衡水中裕铁信防水技术有限公司 | Environment-friendly flame-retardant waterproof material and preparation method and application thereof |
Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101805477A (en) * | 2010-05-11 | 2010-08-18 | 赵根生 | Waterproof product containing linear low density polyethylene and preparation method thereof |
| CN101942151A (en) * | 2009-07-10 | 2011-01-12 | 广东华声电器实业有限公司 | CPE (Chlorinated Polyethylene)/POE (Polyolefin Elastomer)/LDPE (Low-Density Polyethylene) component type insulating rubber and preparation method thereof |
| CN101948581A (en) * | 2010-08-31 | 2011-01-19 | 杭州高新绝缘材料有限公司 | Intumescent flame retardant polyethylene containing organosilicon compound |
| CN103102567A (en) * | 2012-11-13 | 2013-05-15 | 合肥朗胜新材料有限公司 | LDPE (Low-density polyethylene)/EVA (ethylene-vinyl acetate copolymer)/CPE (chlorinated polyethylene) composite foam material and preparation method thereof |
| CN103396613A (en) * | 2013-07-25 | 2013-11-20 | 杭州鸿雁管道系统科技有限公司 | Anti-bacterial beta-PP (Propene Polymer) pipe fitting and manufacturing method thereof |
-
2014
- 2014-11-24 CN CN201410677984.7A patent/CN104403169A/en active Pending
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101942151A (en) * | 2009-07-10 | 2011-01-12 | 广东华声电器实业有限公司 | CPE (Chlorinated Polyethylene)/POE (Polyolefin Elastomer)/LDPE (Low-Density Polyethylene) component type insulating rubber and preparation method thereof |
| CN101805477A (en) * | 2010-05-11 | 2010-08-18 | 赵根生 | Waterproof product containing linear low density polyethylene and preparation method thereof |
| CN101948581A (en) * | 2010-08-31 | 2011-01-19 | 杭州高新绝缘材料有限公司 | Intumescent flame retardant polyethylene containing organosilicon compound |
| CN103102567A (en) * | 2012-11-13 | 2013-05-15 | 合肥朗胜新材料有限公司 | LDPE (Low-density polyethylene)/EVA (ethylene-vinyl acetate copolymer)/CPE (chlorinated polyethylene) composite foam material and preparation method thereof |
| CN103396613A (en) * | 2013-07-25 | 2013-11-20 | 杭州鸿雁管道系统科技有限公司 | Anti-bacterial beta-PP (Propene Polymer) pipe fitting and manufacturing method thereof |
Non-Patent Citations (4)
| Title |
|---|
| 张丹枫: "《烯烃聚合》", 30 September 2014, 华东理工大学出版社 * |
| 徐百平: "《塑料挤出成型技术》", 31 August 2011, 中国轻工业出版社 * |
| 汪多仁: "《绿色增塑剂》", 31 October 2011, 科学技术文献出版社 * |
| 涂长信: "《现代生活与化学》", 31 August 2006, 山东大学出版社 * |
Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105754178A (en) * | 2016-03-01 | 2016-07-13 | 苏州市贝克生物科技有限公司 | Composite material for transfusion bag and preparation method of composite material |
| CN106800767A (en) * | 2016-06-17 | 2017-06-06 | 无锡英普林纳米科技有限公司 | A kind of high intensity anti-biotic material for nano-imprinting apparatus |
| CN107334653A (en) * | 2017-07-12 | 2017-11-10 | 南雄鼎成新材料科技有限公司 | A kind of antibacterial anti-dandruff and itching-relieving shampoo with treatment containing organosilicon quaternary ammonium salt |
| CN112940958A (en) * | 2020-12-02 | 2021-06-11 | 浙大宁波理工学院 | Strain capable of effectively degrading short-chain chlorinated paraffin, and rapid screening method and application thereof |
| CN112940958B (en) * | 2020-12-02 | 2022-05-17 | 浙大宁波理工学院 | Strain capable of effectively degrading short-chain chlorinated paraffin, and rapid screening method and application thereof |
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| CN117229584B (en) * | 2023-11-10 | 2024-01-30 | 衡水中裕铁信防水技术有限公司 | Environment-friendly flame-retardant waterproof material and preparation method and application thereof |
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