CN101732203A - White spot-eliminating biological dressing and preparation method thereof - Google Patents
White spot-eliminating biological dressing and preparation method thereof Download PDFInfo
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- CN101732203A CN101732203A CN200910232186A CN200910232186A CN101732203A CN 101732203 A CN101732203 A CN 101732203A CN 200910232186 A CN200910232186 A CN 200910232186A CN 200910232186 A CN200910232186 A CN 200910232186A CN 101732203 A CN101732203 A CN 101732203A
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Abstract
The invention relates to a white spot-eliminating biological dressing and a preparation method thereof, belonging to the technical field of medical supplies. The biological dressing comprises the following main components by weight percent: 5-12% of green Chinese onion juice, 0.8-3.0% of plant essence of root of perny germander, 3-8% of chitin, 0.5-1.0% of emulsifier, 0.3-0.8% of skin penetration agent, 0.2-0.5% of fatty acid, 0.2-0.5% of moisturizing agent and the balance of water. When in preparation, the emulsifier and the fatty acid are heated to melt, thereby forming a first group of emulsion; the moisturizing agent is evenly added in the water for forming a second group of emulsion; the first group of the emulsion is gradually added into the second group of the emulsion, and the mixture is evenly stirred, thereby forming the mixed emulsion; the green Chinese onion juice, the plant essence of root of perny germander, the chitin and the skin penetration agent are added in the mixed emulsion and evenly stirred; and the mixture is further cooled and packaged for preparing the biological dressing. The biological dressing has sufficient scientific evidence and can realize thoughtful consideration and reasonable compatibility. The clinical application proves that the emulsion agent simultaneously has the significant functions of eliminating white spots, removing scars and stopping itching and has no toxicity or side effects.
Description
Technical field
The present invention relates to a kind of white macula biological dressing that disappears, especially a kind ofly cure mainly white macula, have the white macula biological dressing that disappears concurrently, also relate to its preparation method simultaneously, belong to field of medical article technology except that scar, antipruritic function.
Background technology
As everyone knows, often there are cutaneous pigmentation or pigment obscission in empyrosis wound surface healing back except that staying cicatrix, and pigmentation along with can disappearing gradually usually in continuity in time, and the white macula that the pigment disappearance forms then is difficult to disappear even is unchangeable.This has brought great psychic pain and psychic trauma to the patient.In addition, the patient of some constitutional Bai Dianfeng, leukoplakia vulvae usually is subjected to the white macula puzzlement to endure torment to the fullest extent, discriminate against even the forfeiture confidence.
Retrieval is found, application number is that 00132225.7 Chinese patent application discloses a kind of sun-shielding spot-removing chitin cream, this frost comprises: the sun-proof barrier film 0.5mg of chitin (1), chitin moisturizer 0.5mg (2) has effect of dispelling spots to sun-proof barrier film 0.5mg of chitin (1) and chitin moisturizer 0.5mg (2) solvent to human face's skin together.Application number is that 200510032350.7 Chinese invention patent discloses a kind of skin care item that enzymatic compositions is an additive that contain, be made up of glutathione transferase, glutathion and chitin polysaccharide, the percentage by weight of said components in skin care item is followed successively by 0.01～1.0,0.4～4.0 and 1.0～10.The skin care item of this invention development are through animal experiment, and to rat skin vacuum response, and tool obviously suppresses the effect of lipid peroxide; Therefore be a kind of skin care item with speckle dispelling, anti-speckle function.But its function singleness.According to the applicant.Understand, at present with white macula, remove the skin care item product that scar, antipruritic three kinds of functions be integrated in one and do not appear in the newspapers, particularly be that the biological dressing that carrier format occurs does not appear in the newspapers especially with the emulsion agent.
Summary of the invention
The objective of the invention is to: propose a kind of white macula to be had desirable curative effect, have concurrently simultaneously except that scar, antipruritic function, and the white macula biological dressing that disappears that has no side effect, provide its preparation method simultaneously.
In order to reach above purpose, the white macula biological dressing that disappears of the present invention is made by following component:
1. big Sucus Allii Fistulosi: 5-12%
2. Radix Teucrii Pernyi (TGL) plant essence: 0.8-3.0%
3. chitin: 3-8%
4. emulsifying agent (for example stearic acid polyoxyethylene ether, polyoxyethylene ether, sodium lauryl sulphate): 0.5-1.0%
5. skin penetrant (for example azone, thiophene ketone, laurocapram): 0.3-0.8%
6. fatty acid: 0.2-0.5%
7. wetting agent (for example glycerol, glycerol etc.): 0.2%-0.5%
8. water: surplus
The disappear preparation method of white macula biological dressing of the present invention may further comprise the steps:
The first step, emulsifying agent, fatty acid heated (to 80 ± 2 ℃) dissolve, and become first group of emulsion;
Second goes on foot, wetting agent is evenly added in the entry, becomes second group of emulsion;
The 3rd the step, first group of emulsion added second group of emulsion gradually, stir, mixing time is generally 10-20 minute, becomes mixed emulsion;
The 4th goes on foot, big Sucus Allii Fistulosi, Radix Teucrii Pernyi plant essence, chitin, skin penetrant is added in the mixed emulsion, stirs, and mixing time is generally 25-35 minute;
The 5th the step, be cooled to the emulsion agent shape, promptly make the white macula biological dressing that disappears of the present invention.The plastic tube packaging that the said goods can be propped up with 10g/ during packing.
Studies show that white macula is to lack in epidermis and pigment cell due to the tryrosinase, the white macula position is owing to lack metal trace elements such as Cu, Zn, Fe, and tyrosinase activity reduces in the body and make, and has influenced melanic anabolism, produces pathological changes.Show according to up-to-date flame atomic absorption spectrometry determination test, be rich in various inorganic elementss such as K, Ca, Na, Mg, Zn, Cu, Cr and Cd in the Herba Alii fistulosi.Primary raw material of the present invention adopts the big Sucus Allii Fistulosi of pure natural, can augment the partial Cu of patient, metallic elements such as Zn, Fe, and tyrosinase activity is strengthened, and melanin is synthesized accelerate, increase, merge, and finally covers white macula fully.The Radix Teucrii Pernyi plant essence directly acts on skin surface, can eliminate white macula, and with an outer combined effect in the natural big Sucus Allii Fistulosi one, treating both the principal and secondary aspects of a disease is eliminated white macula, and is faster more thorough.Chitin is in the effect of natural big Sucus Allii Fistulosi dialogue speckle, rely on it nontoxic and have a characteristic of biocompatibility, the hypertrophy that can stop the skin wound fibrous tissue, when can generate, act on, to hypertrophy and postoperative abnormal pigmentary deposit on the skin trace, keloidal softening, the flat good facilitation that has at melanin.Wetting agent can absorb airborne moisture content, keeps the long term effect of product, effectively pins horny layer moisture, makes mastic clearly and not glutinous greasy, promotes the absorption of skin to effective ingredient, accelerates healing rate.
Therefore, the present invention has sufficient scientific basis, and carefully thinks out, and compatibility is reasonable.Clinical practice proves, emulsion agent of the present invention has simultaneously and disappears white macula significantly and remove scar, antipruritic function, and has no side effect.
The specific embodiment
Embodiment one
The white macula biological dressing that disappears of present embodiment is made by following component:
1. big Sucus Allii Fistulosi: 5%
2. Radix Teucrii Pernyi (TGL) plant essence: 1%
3. chitin: 3%
4. stearic acid polyoxyethylene ether is as emulsifying agent: 0.5%
5. azone is as skin penetrant: 0.3%
6. fatty acid: 0.2%
7. glycerol is as wetting agent: 0.2%
8. water: surplus
Preparation process is:
1) emulsifying agent, fatty acid are heated to about 80 ℃, dissolves, become first group of emulsion;
2) wetting agent is evenly added in the entry, become second group of emulsion;
3) first group of emulsion added second group of emulsion gradually, stir, stirred 10-20 minute, become mixed emulsion;
4) big Sucus Allii Fistulosi, Radix Teucrii Pernyi plant essence, chitin, skin penetrant are added in the mixed emulsion, stir, stirred 25-35 minute;
5) make the white macula biological dressing that disappears of emulsion agent shape after the cooling, the plastic tube packaging that props up with 10g/.
During use, the white macula biological dressing that will disappear is coated in the wound healing place, can activate the melanin of white macula periphery gradually, thereby melanin is spread to balance to white space, and white macula is disappeared.Wherein the effect function of the big Sucus Allii Fistulosi of food plant is the white macula that disappears, because big Sucus Allii Fistulosi can promote the propagation and the local immunomodulating of dermal melanin cell; Form the black particle shape material at patient's white macula place, and increase gradually, merge, so that cover white macula fully, make the white macula disappearance.Remove scar mainly by nontoxic and have a biomaterial chitin of biocompatibility, chitin is favourable to the growth of skin histology, therefore the hypertrophy that can stop the skin wound fibrous tissue is to hypertrophy and postoperative scar, keloidal softening, the flat good facilitation that has.Natural TGL plant essence then has ideal antipruritic effect, and this raw material comes from nature, has the antipruritic function of good uniqueness.Especially, after above-mentioned component mixed, have complementary potentiation, for example, after emulsifyings such as TGL plant essence and big Sucus Allii Fistulosi are merged, under can cooperating in the stimulation of big Sucus Allii Fistulosi, the cicatrix pruritus is produced more significant elimination effect.
Acute oral toxicity test (mice) situation is as follows:
One, material and animal
1. tried thing: sample is a liquid, takes by weighing sample 5000mg and adds distilled water to 20ml, is mixed with and is tried thing.
2. animal: 20 of healthy ICR mices, Shanghai Slac Experimental Animal Co., Ltd. provides, secondary, body weight 18-22g, male and female half and half, the quality certification number: SCXK (Shanghai) 2003-0003 number.
3. experimental condition: feed resource and card number: Jiangpu development laboratory animal feed factory, No. the 95001st, work (raising) word; The laboratory animal environmental facility quality certification number: SYXK (Soviet Union) 2002-0004 number; Ambient temperature: 22 ± 2 ℃; Relative temperature: 40-70%; Key instrument: electronic scale (DS-671), electronic balance (LP123).
Two, method
1. test basis: Ministry of Public Health " disinfection technology standard " (version in 2002), the test of 2.3.1 acute oral poison.
2. test method(s) to greatest extent once: behind the animal overnight fasting, tried thing and once irritate stomach with the dosage per os of 5000mg/kg b.wt., capacity is 20ml/kg b.wt., irritates 4h feeding behind the stomach, observation period 2w.
Three, result of the test
Do not see obvious poisoning manifestations behind the male and female mouse stomach, no animal dead in the observation period.
Dead mouse number and phase LD
50Value
Four, conclusion
The rainforest white macula disappears male and female chmice acute per os half is extremely measured the LD50 value all greater than 5000mg/kg b.wt., the nontoxic level in true border.
The survey report result who is numbered 2006ZC057 that authoritative institution provides is as follows
The clinical practice situation report of Nanjing Military Command's hospital general's Department of B urn is as follows:
1, clinical data
Male's 18 examples, the age 19, because of staying the skin of forearm white macula behind burn or the scalding healing, white macula area 3-10 to 5-2cm did not wait, and once uses multiple speckle dispelling preparation for treating outside the institute all to no effect to 42 years old.Check and find that part and normal skin aberration are clear.Give the white macula cream partial smearing that disappears, every day 2 to 3 times, white macula place, 8 week back is dispersed in pigment granule and occurs, and merges gradually in flakes, and white macula disappears, and continues 6 weeks of medication, there is no recurrence.
2, discuss
Can occur the local skin pigment formation white macula that comes off behind the burn wound healing, clinical manifestation is similar to vitiligo, claims " burn back vitiligo " again, and such white macula seldom can recover normally in a short time, sustainable several months, several years even all the life.Genesis mechanism is still unclear, does not still have effective Therapeutic Method at present.
The skin burn white macula that causes of burn is more sees that incidence rate is about 2-5%, influence attractive in appearancely, and patient is misery comparatively.The mechanism of action that white macula disappears is to promote melanocyte propagation and local skin immunomodulating, and local symptom is improved rapidly in the application process, reaches to eliminate the white macula effect, and said preparation is easy to use, does not find any ill effect in the application process.
The clinical practice situation report of Nanjing Medical University's two attached institute Department of B urns is as follows:
The burn white macula is a kind of plain stubborn dermatosis, does not have special Therapeutic Method at present.My institute's recent application white macula leukoderma 38 examples behind the wound healing that treatment causes because of burn that disappear, respond well.It is not only effective to the burn white macula to find in the application process that white macula disappears, and the primary cutaneous white macula is taken off lose and vitiligo also has good effect.
Application process: white macula cream (being the white macula biological dressing that the disappears of the present invention) partial smearing that disappears, every day twice, white macula fades away after continuous use 4-6 week, continues 4 weeks of medication, there is no recurrence.Said preparation is easy to use, does not find any ill effect in the application process.
These have been verified all that the present invention has simultaneously and have disappeared white macula significantly and remove scar, antipruritic function, and have had no side effect.
Embodiment two
The white macula biological dressing that disappears of present embodiment is made by following component:
1. big Sucus Allii Fistulosi: 8%
2. Radix Teucrii Pernyi (TGL) plant essence: 2%
3. chitin: 6%
4. polyoxyethylene ether: 0.8%
5. thiophene ketone: 0.6%
6. fatty acid: 0.4%
7. glycerol: 0.3%
8. water: surplus
Preparation method and result of use and embodiment one are basic identical.
Embodiment three
The white macula biological dressing that disappears of present embodiment is made by following component:
1. big Sucus Allii Fistulosi: 12%
2. Radix Teucrii Pernyi (TGL) plant essence: 3.0%
3. chitin: 8%
4. sodium lauryl sulphate: 1.0%
5. laurocapram: 0.8%
6. fatty acid: 0.5%
7. glycerol: 0.5%
8. water: surplus
Preparation method and result of use and embodiment one are basic identical.
Claims (6)
1. white macula biological dressing that disappears, make by following component:
Big Sucus Allii Fistulosi 5-12%
Radix Teucrii Pernyi plant essence 0.8-3.0%
Chitin 3-8%
Emulsifying agent 0.5-1.0%
Skin penetrant 0.3-0.8%
Fatty acid 0.2-0.5%
Wetting agent 0.2%-0.5%
Water surplus.
2. the white macula biological dressing that disappears according to claim 1 is characterized in that: described emulsifying agent is one of stearic acid polyoxyethylene ether, polyoxyethylene ether or sodium lauryl sulphate.
3. the white macula biological dressing that disappears according to claim 1 is characterized in that: described skin penetrant is one of azone, thiophene ketone or laurocapram.
4. the white macula biological dressing that disappears according to claim 1 is characterized in that: described wetting agent is one of glycerol, glycerol.
5. the white macula biological dressing preparation method that disappears according to claim 1 is characterized in that may further comprise the steps:
The first step, emulsifying agent, fatty acid heated dissolve, become first group of emulsion;
Second goes on foot, wetting agent is evenly added in the entry, becomes second group of emulsion;
The 3rd the step, first group of emulsion added second group of emulsion gradually, stir, become mixed emulsion;
The 4th goes on foot, big Sucus Allii Fistulosi, Radix Teucrii Pernyi plant essence, chitin, skin penetrant is added in the mixed emulsion, stirs;
The 5th the step, be cooled to the emulsion agent shape, promptly make the white macula biological dressing that disappears of the present invention.
6. the white macula biological dressing preparation method that disappears according to claim 5 is characterized in that: the temperature of heating of the described first step is 80 ± 2 ℃; The mixing time in described the 3rd step is 10-20 minute; The mixing time in described the 4th step is 25-35 minute.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN200910232186A CN101732203A (en) | 2009-12-02 | 2009-12-02 | White spot-eliminating biological dressing and preparation method thereof |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN200910232186A CN101732203A (en) | 2009-12-02 | 2009-12-02 | White spot-eliminating biological dressing and preparation method thereof |
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| Publication Number | Publication Date |
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| CN101732203A true CN101732203A (en) | 2010-06-16 |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103070801A (en) * | 2013-01-09 | 2013-05-01 | 三峡大学 | Biomembrane skin water retention cosmetology method |
| CN104368035A (en) * | 2013-08-13 | 2015-02-25 | 凌峰 | Biological dressing for eliminating white spots and scars on human body |
| CN107693421A (en) * | 2017-10-20 | 2018-02-16 | 烟台宇诚企业管理咨询有限公司 | A kind of scar eliminating composition containing marine organism extract and preparation method thereof |
-
2009
- 2009-12-02 CN CN200910232186A patent/CN101732203A/en active Pending
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103070801A (en) * | 2013-01-09 | 2013-05-01 | 三峡大学 | Biomembrane skin water retention cosmetology method |
| CN103070801B (en) * | 2013-01-09 | 2014-05-28 | 三峡大学 | Biomembrane skin water retention cosmetology method |
| CN104368035A (en) * | 2013-08-13 | 2015-02-25 | 凌峰 | Biological dressing for eliminating white spots and scars on human body |
| CN107693421A (en) * | 2017-10-20 | 2018-02-16 | 烟台宇诚企业管理咨询有限公司 | A kind of scar eliminating composition containing marine organism extract and preparation method thereof |
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Application publication date: 20100616 |