CN101720786B - Clinical surgical instrument disinfectant - Google Patents
Clinical surgical instrument disinfectant Download PDFInfo
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- CN101720786B CN101720786B CN2009102299905A CN200910229990A CN101720786B CN 101720786 B CN101720786 B CN 101720786B CN 2009102299905 A CN2009102299905 A CN 2009102299905A CN 200910229990 A CN200910229990 A CN 200910229990A CN 101720786 B CN101720786 B CN 101720786B
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- silicone oil
- disinfectant
- surgical instrument
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Abstract
The invention belongs to the technical field of medical disinfectants and relates to a clinical surgical instrument disinfectant. The disinfectant is prepared by adopting the following steps of: getting 100ml of methyl silicone oil and adding 1g of chlorhexidine, 0.5g of polyhexamethylene guanidine and 0.5g of polyvinylpyrrolidone; stirring and dissolving to obtain a methyl silicone oil solution; getting 500ml of water, adding 5g of hypochlorite and 2g of sodium dodecyl sulfate, and stirring and dissolving to obtain an aqueous solution; adding the aqueous solution, the methyl silicone oil solution and 0.5g of polysorbates 80 into a hermetic container; and stirring under ultrasonication and uniformly mixing to obtain an emulsion. The disinfectant has the advantages of stable chemical property, safety, high efficiency and long duration time, and reduces the disinfection number of times of surgical instruments and the probability of surgical infections.
Description
Technical field
The present invention relates to a kind of clinical surgical instrument disinfectant, belong to the technical field of medical disinfectant.
Background technology
The disinfectant that uses at present is generally the aqueous disinfecting agent, and the retention time on operating theater instruments is shorter, has increased the sterilization number of times of operating theater instruments, simultaneously, has strengthened the probability of postoperative infection.
Summary of the invention
The present invention provides a kind of chemical property stable, safe and efficient in order to overcome the deficiency of above technical elements, longer duration, the sterilization number of times of minimizing operating theater instruments, the probability of minimizing postoperative infection.
The present invention realizes through following measure:
The present invention relates to a kind of clinical surgical instrument disinfectant, it is characterized in that adopting following steps to process:
(1) get methyl-silicone oil 100ml, add Chlorhexidine 1g polyhexamethylene guanide 0.5g, polyvinylpyrrolidone 0.5g, stirring and dissolving gets methyl-silicone oil solution;
(2) water intaking 500ml adds hypochlorite 5g, dodecyl sodium sulfate 2g, and stirring and dissolving gets the aqueous solution;
(3) with the Tween 80 of the above-mentioned aqueous solution, methyl-silicone oil solution and 0.5g, add in the airtight container, under ultrasonic Treatment, stir, mix, get emulsion.
The clinical surgical instrument disinfectant of the invention described above, preferred, the frequency of described ultrasonic Treatment is 20KHz～40KHz, power is 10-15KW.
Above-mentioned clinical surgical instrument disinfectant is mixed in order to make emulsion more fully, and the speed that stirs described in the step (3) is preferably 30-50 rev/min.
Methyl-silicone oil of the present invention has tasteless nontoxic, has physiology inertia, good chemical stability, electric edge property and weather resistance, and range of viscosities is wide, and freezing point is low, and flash-point is high, and operating theater instruments and human body are not had bad reaction, and safety is good.On the other hand, methyl-silicone oil has the advantages that hydrophobic performance is good, surface tension is little, can on operating theater instruments, form the layer of even liquid film; The adhesion property of above-mentioned Huaihe River film and operating theater instruments is fine, adds the not volatile characteristics of methyl-silicone oil, can make methyl-silicone oil and be dissolved in the interior medicine of methyl-silicone oil to remain on for a long time on the operating theater instruments, makes operating theater instruments have the bactericidal property of long period.
Beneficial effect of the present invention does, it is stable to have chemical property, safe and efficient, and longer duration has reduced the sterilization number of times of operating theater instruments, has reduced the probability of postoperative infection.
Embodiment:
Embodiment 1
The clinical surgical instrument disinfectant of present embodiment, adopt following steps to process:
Get methyl-silicone oil 100ml, add Chlorhexidine 1g polyhexamethylene guanide 0.5g, polyvinylpyrrolidone 0.5g, stirring and dissolving gets methyl-silicone oil solution;
Water intaking 500ml adds hypochlorite 5g, dodecyl sodium sulfate 2g, and stirring and dissolving gets the aqueous solution;
With the Tween 80 of the above-mentioned aqueous solution, methyl-silicone oil solution and 0.5g, add in the airtight container, under ultrasonic Treatment, stir, mix, get emulsion.The frequency of described ultrasonic Treatment is 30KHz, and power is 10KW; The speed that stirs is 50 rev/mins.
Embodiment 2
The clinical surgical instrument disinfectant of present embodiment, adopt following steps to process:
Get methyl-silicone oil 100ml, add Chlorhexidine 1g polyhexamethylene guanide 0.5g, polyvinylpyrrolidone 0.5g, stirring and dissolving gets methyl-silicone oil solution;
Water intaking 500ml adds hypochlorite 5g, dodecyl sodium sulfate 2g, and stirring and dissolving gets the aqueous solution;
With the Tween 80 of the above-mentioned aqueous solution, methyl-silicone oil solution and 0.5g, add in the airtight container, under ultrasonic Treatment, stir, mix, get emulsion.The frequency of described ultrasonic Treatment is 40KHz, and power is 15KW; The speed that stirs is 30 rev/mins.
Test case 1
Clinical surgical instrument disinfectant of the present invention and glutaraldehyde disinfectant are used for operating theater instruments, and bactericidal effect compares, and the result is following:
| Gram-positive, negative bacterium | Ball purulence liver bacterium | Microspironema pallidum | Tulase | Brood cell's (tetanus, gangrene) | Hepatitis type B virus | AIDS virus | |
| Embodiment 1 | Killed in 15 minutes 100% | Killed in 15 minutes 100% | Killed in 15 minutes 100% | Killed in 25 minutes 100% | Killed in 30 minutes 100% | Killed in 30 minutes 100% | Killed in 30 minutes 100% |
| Embodiment 2 | Killed in 15 minutes 100% | Killed in 15 minutes 100% | Killed in 15 minutes 100% | Killed in 25 minutes 100% | Killed in 30 minutes 100% | Killed in 30 minutes 100% | Killed in 35 minutes 100% |
| Glutaraldehyde disinfectant | Killed in 25 minutes 100% | Killed in 25 minutes 100% | Killed in 25 minutes 100% | Killed in 50 minutes 100% | Killed in 50 minutes 100% | Killed in 50 minutes 100% | Killed in 60 minutes 100% |
Test case 2
After clinical surgical instrument carried out disinfection with clinical surgical instrument disinfectant of the present invention and glutaraldehyde disinfectant respectively, be positioned over indoorly, after 12 hours, still have the disinfectant liquid film with the clinical surgical instrument of disinfectant sterilization of the present invention, bacteria living is not seen on the surface.Clinical surgical instrument with after the glutaraldehyde disinfectant sterilization does not have the disinfectant liquid film, and there is the part bacteria living on the surface.
Claims (3)
1. clinical surgical instrument disinfectant is characterized in that adopting following steps to process:
(1) get methyl-silicone oil 100ml, add Chlorhexidine 1g, polyhexamethylene guanide 0.5g, polyvinylpyrrolidone 0.5g, stirring and dissolving gets methyl-silicone oil solution;
(2) water intaking 500ml adds hypochlorite 5g, dodecyl sodium sulfate 2g, and stirring and dissolving gets the aqueous solution;
(3) with the Tween 80 of the above-mentioned aqueous solution, methyl-silicone oil solution and 0.5g, add in the airtight container, under ultrasonic Treatment, stir, mix, get emulsion.
2. clinical surgical instrument disinfectant according to claim 1 is characterized in that: the frequency of described ultrasonic Treatment is 20KHz～40KHz, and power is 10-15KW.
3. clinical surgical instrument disinfectant according to claim 1 is characterized in that: the speed that stirs described in the step (3) is 30-50 rev/min.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2009102299905A CN101720786B (en) | 2009-11-30 | 2009-11-30 | Clinical surgical instrument disinfectant |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2009102299905A CN101720786B (en) | 2009-11-30 | 2009-11-30 | Clinical surgical instrument disinfectant |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN101720786A CN101720786A (en) | 2010-06-09 |
| CN101720786B true CN101720786B (en) | 2012-02-08 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN2009102299905A Expired - Fee Related CN101720786B (en) | 2009-11-30 | 2009-11-30 | Clinical surgical instrument disinfectant |
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| CN (1) | CN101720786B (en) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102178963B (en) * | 2011-04-13 | 2012-10-10 | 张英联 | Medical ultrasonic couplant and preparation method of couplant |
| CA2898652A1 (en) | 2013-01-25 | 2014-07-31 | Kemira Oyj | Biocide composition and method for treating water |
| CN109907069A (en) * | 2019-03-25 | 2019-06-21 | 天津市郁峰化工有限公司 | A kind of hypochlorous acid thimerosal and preparation method thereof |
| KR102340804B1 (en) * | 2019-07-22 | 2021-12-17 | 주식회사 휴온스메디케어 | Water-soluble disinfectant composition with enhanced antibacterial durability stability comprising chlorhexidine or derivatives thereof and fiber type disinfectant comprising the same |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE19517463A1 (en) * | 1995-05-12 | 1996-11-14 | Degussa | Process for the algicidal treatment of water |
| WO2008088394A3 (en) * | 2006-08-24 | 2008-11-27 | Dow Reichhold Specialty Latex | Anionic latex as a carrier for bioactive ingredients |
-
2009
- 2009-11-30 CN CN2009102299905A patent/CN101720786B/en not_active Expired - Fee Related
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE19517463A1 (en) * | 1995-05-12 | 1996-11-14 | Degussa | Process for the algicidal treatment of water |
| WO2008088394A3 (en) * | 2006-08-24 | 2008-11-27 | Dow Reichhold Specialty Latex | Anionic latex as a carrier for bioactive ingredients |
Non-Patent Citations (1)
| Title |
|---|
| 崔玉杰等.四种复方聚六亚甲基双胍消毒剂对白色念珠菌杀灭效果比较.《中国消毒学杂志》.2008,(第04期), * |
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| CN101720786A (en) | 2010-06-09 |
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Granted publication date: 20120208 Termination date: 20121130 |