CN101972271B - Chlorine dioxide mucous membrane gel and preparation method thereof - Google Patents
Chlorine dioxide mucous membrane gel and preparation method thereof Download PDFInfo
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- CN101972271B CN101972271B CN2010105253605A CN201010525360A CN101972271B CN 101972271 B CN101972271 B CN 101972271B CN 2010105253605 A CN2010105253605 A CN 2010105253605A CN 201010525360 A CN201010525360 A CN 201010525360A CN 101972271 B CN101972271 B CN 101972271B
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- disodium ethylene
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- OSVXSBDYLRYLIG-UHFFFAOYSA-N dioxidochlorine(.) Chemical compound O=Cl=O OSVXSBDYLRYLIG-UHFFFAOYSA-N 0.000 title claims abstract description 148
- 239000004155 Chlorine dioxide Substances 0.000 title claims abstract description 74
- 235000019398 chlorine dioxide Nutrition 0.000 title claims abstract description 74
- 238000002360 preparation method Methods 0.000 title abstract description 5
- 210000004400 mucous membrane Anatomy 0.000 title abstract 3
- 238000001879 gelation Methods 0.000 title description 3
- 239000007864 aqueous solution Substances 0.000 claims abstract description 64
- 210000004877 mucosa Anatomy 0.000 claims abstract description 38
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims abstract description 33
- 239000011259 mixed solution Substances 0.000 claims abstract description 27
- ZGTMUACCHSMWAC-UHFFFAOYSA-L EDTA disodium salt (anhydrous) Chemical compound [Na+].[Na+].OC(=O)CN(CC([O-])=O)CCN(CC(O)=O)CC([O-])=O ZGTMUACCHSMWAC-UHFFFAOYSA-L 0.000 claims abstract description 16
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 claims abstract description 16
- 239000000463 material Substances 0.000 claims abstract description 16
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 13
- 239000008213 purified water Substances 0.000 claims abstract description 11
- BDOYKFSQFYNPKF-UHFFFAOYSA-N 2-[2-[bis(carboxymethyl)amino]ethyl-(carboxymethyl)amino]acetic acid;sodium Chemical compound [Na].[Na].OC(=O)CN(CC(O)=O)CCN(CC(O)=O)CC(O)=O BDOYKFSQFYNPKF-UHFFFAOYSA-N 0.000 claims description 24
- 238000000034 method Methods 0.000 claims description 24
- WLAMNBDJUVNPJU-UHFFFAOYSA-N 2-methylbutyric acid Chemical compound CCC(C)C(O)=O WLAMNBDJUVNPJU-UHFFFAOYSA-N 0.000 claims description 21
- 229940082484 carbomer-934 Drugs 0.000 claims description 21
- 238000003756 stirring Methods 0.000 claims description 13
- -1 hydroxypropyl Chemical group 0.000 claims description 11
- 239000012729 immediate-release (IR) formulation Substances 0.000 claims description 11
- 238000002156 mixing Methods 0.000 claims description 6
- 239000000203 mixture Substances 0.000 claims description 6
- 235000011121 sodium hydroxide Nutrition 0.000 claims description 6
- 238000010792 warming Methods 0.000 claims description 5
- 238000004659 sterilization and disinfection Methods 0.000 abstract description 15
- 244000005700 microbiome Species 0.000 abstract description 12
- 230000001954 sterilising effect Effects 0.000 abstract description 12
- 210000000214 mouth Anatomy 0.000 abstract description 9
- 210000000436 anus Anatomy 0.000 abstract description 7
- 230000000694 effects Effects 0.000 abstract description 7
- 210000003928 nasal cavity Anatomy 0.000 abstract description 7
- 210000001215 vagina Anatomy 0.000 abstract description 6
- NIXOWILDQLNWCW-UHFFFAOYSA-N Acrylic acid Chemical compound OC(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 abstract description 4
- 229920002125 Sokalan® Polymers 0.000 abstract description 4
- 229960001631 carbomer Drugs 0.000 abstract description 4
- 210000003097 mucus Anatomy 0.000 abstract description 3
- 239000003109 Disodium ethylene diamine tetraacetate Substances 0.000 abstract 5
- 235000019301 disodium ethylene diamine tetraacetate Nutrition 0.000 abstract 5
- 238000001816 cooling Methods 0.000 abstract 1
- 239000001866 hydroxypropyl methyl cellulose Substances 0.000 abstract 1
- 229920003088 hydroxypropyl methyl cellulose Polymers 0.000 abstract 1
- 235000010979 hydroxypropyl methyl cellulose Nutrition 0.000 abstract 1
- UFVKGYZPFZQRLF-UHFFFAOYSA-N hydroxypropyl methyl cellulose Chemical compound OC1C(O)C(OC)OC(CO)C1OC1C(O)C(O)C(OC2C(C(O)C(OC3C(C(O)C(O)C(CO)O3)O)C(CO)O2)O)C(CO)O1 UFVKGYZPFZQRLF-UHFFFAOYSA-N 0.000 abstract 1
- 239000000499 gel Substances 0.000 description 44
- 230000000844 anti-bacterial effect Effects 0.000 description 12
- 239000002585 base Substances 0.000 description 11
- 238000004332 deodorization Methods 0.000 description 8
- 238000004061 bleaching Methods 0.000 description 7
- 239000000243 solution Substances 0.000 description 7
- 241000700605 Viruses Species 0.000 description 5
- 208000025865 Ulcer Diseases 0.000 description 4
- 231100000397 ulcer Toxicity 0.000 description 4
- 244000063299 Bacillus subtilis Species 0.000 description 3
- 235000014469 Bacillus subtilis Nutrition 0.000 description 3
- 241000894006 Bacteria Species 0.000 description 3
- 241000194032 Enterococcus faecalis Species 0.000 description 3
- 241000588724 Escherichia coli Species 0.000 description 3
- 241000726221 Gemma Species 0.000 description 3
- 206010018612 Gonorrhoea Diseases 0.000 description 3
- 241000589517 Pseudomonas aeruginosa Species 0.000 description 3
- 241000607142 Salmonella Species 0.000 description 3
- 241000191967 Staphylococcus aureus Species 0.000 description 3
- 241000589884 Treponema pallidum Species 0.000 description 3
- 206010047799 Vulvovaginitis trichomonal Diseases 0.000 description 3
- 230000003385 bacteriostatic effect Effects 0.000 description 3
- 238000006243 chemical reaction Methods 0.000 description 3
- 208000001786 gonorrhea Diseases 0.000 description 3
- 208000006454 hepatitis Diseases 0.000 description 3
- 231100000283 hepatitis Toxicity 0.000 description 3
- 208000015181 infectious disease Diseases 0.000 description 3
- 239000003112 inhibitor Substances 0.000 description 3
- 230000005764 inhibitory process Effects 0.000 description 3
- 229910021645 metal ion Inorganic materials 0.000 description 3
- 238000007254 oxidation reaction Methods 0.000 description 3
- 206010002180 Anal ulcer Diseases 0.000 description 2
- 208000016583 Anus disease Diseases 0.000 description 2
- CURLTUGMZLYLDI-UHFFFAOYSA-N Carbon dioxide Chemical compound O=C=O CURLTUGMZLYLDI-UHFFFAOYSA-N 0.000 description 2
- 241000606161 Chlamydia Species 0.000 description 2
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 2
- 208000009531 Fissure in Ano Diseases 0.000 description 2
- 241000233866 Fungi Species 0.000 description 2
- 102000003886 Glycoproteins Human genes 0.000 description 2
- 108090000288 Glycoproteins Proteins 0.000 description 2
- 206010061218 Inflammation Diseases 0.000 description 2
- 241000204031 Mycoplasma Species 0.000 description 2
- 208000029082 Pelvic Inflammatory Disease Diseases 0.000 description 2
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 2
- 206010046914 Vaginal infection Diseases 0.000 description 2
- 201000008100 Vaginitis Diseases 0.000 description 2
- 230000002159 abnormal effect Effects 0.000 description 2
- 239000000227 bioadhesive Substances 0.000 description 2
- 201000010099 disease Diseases 0.000 description 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 2
- 239000000796 flavoring agent Substances 0.000 description 2
- 235000019634 flavors Nutrition 0.000 description 2
- 239000001257 hydrogen Substances 0.000 description 2
- 229910052739 hydrogen Inorganic materials 0.000 description 2
- 230000004054 inflammatory process Effects 0.000 description 2
- 230000002045 lasting effect Effects 0.000 description 2
- 231100000252 nontoxic Toxicity 0.000 description 2
- 230000003000 nontoxic effect Effects 0.000 description 2
- 230000003647 oxidation Effects 0.000 description 2
- 238000004321 preservation Methods 0.000 description 2
- 206010039083 rhinitis Diseases 0.000 description 2
- 229910001868 water Inorganic materials 0.000 description 2
- 102000004190 Enzymes Human genes 0.000 description 1
- 108090000790 Enzymes Proteins 0.000 description 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 description 1
- AVXURJPOCDRRFD-UHFFFAOYSA-N Hydroxylamine Chemical compound ON AVXURJPOCDRRFD-UHFFFAOYSA-N 0.000 description 1
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 1
- XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 description 1
- PWHULOQIROXLJO-UHFFFAOYSA-N Manganese Chemical compound [Mn] PWHULOQIROXLJO-UHFFFAOYSA-N 0.000 description 1
- 108091034117 Oligonucleotide Proteins 0.000 description 1
- 208000007117 Oral Ulcer Diseases 0.000 description 1
- 244000269722 Thea sinensis Species 0.000 description 1
- GSEJCLTVZPLZKY-UHFFFAOYSA-N Triethanolamine Chemical compound OCCN(CCO)CCO GSEJCLTVZPLZKY-UHFFFAOYSA-N 0.000 description 1
- 239000000853 adhesive Substances 0.000 description 1
- 230000001070 adhesive effect Effects 0.000 description 1
- 229910052783 alkali metal Inorganic materials 0.000 description 1
- 150000001340 alkali metals Chemical class 0.000 description 1
- 208000002399 aphthous stomatitis Diseases 0.000 description 1
- 230000001580 bacterial effect Effects 0.000 description 1
- 210000004666 bacterial spore Anatomy 0.000 description 1
- 230000003115 biocidal effect Effects 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 230000036765 blood level Effects 0.000 description 1
- 239000001569 carbon dioxide Substances 0.000 description 1
- 229910002092 carbon dioxide Inorganic materials 0.000 description 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 description 1
- 230000015556 catabolic process Effects 0.000 description 1
- 238000006555 catalytic reaction Methods 0.000 description 1
- 210000004027 cell Anatomy 0.000 description 1
- 210000002421 cell wall Anatomy 0.000 description 1
- 239000008139 complexing agent Substances 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- 238000006731 degradation reaction Methods 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 230000007613 environmental effect Effects 0.000 description 1
- 210000003608 fece Anatomy 0.000 description 1
- 239000000835 fiber Substances 0.000 description 1
- 210000001035 gastrointestinal tract Anatomy 0.000 description 1
- 208000007565 gingivitis Diseases 0.000 description 1
- 238000010438 heat treatment Methods 0.000 description 1
- 241000411851 herbal medicine Species 0.000 description 1
- 229910052748 manganese Inorganic materials 0.000 description 1
- 239000011572 manganese Substances 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 229910052751 metal Inorganic materials 0.000 description 1
- 239000002184 metal Substances 0.000 description 1
- 210000002200 mouth mucosa Anatomy 0.000 description 1
- 230000001590 oxidative effect Effects 0.000 description 1
- 230000035515 penetration Effects 0.000 description 1
- 201000001245 periodontitis Diseases 0.000 description 1
- 230000002085 persistent effect Effects 0.000 description 1
- 230000002035 prolonged effect Effects 0.000 description 1
- 238000001243 protein synthesis Methods 0.000 description 1
- 210000000582 semen Anatomy 0.000 description 1
- 230000000391 smoking effect Effects 0.000 description 1
- 229910052708 sodium Inorganic materials 0.000 description 1
- 239000011734 sodium Substances 0.000 description 1
- 239000011780 sodium chloride Substances 0.000 description 1
- KKCBUQHMOMHUOY-UHFFFAOYSA-N sodium oxide Chemical compound [O-2].[Na+].[Na+] KKCBUQHMOMHUOY-UHFFFAOYSA-N 0.000 description 1
- 229910001948 sodium oxide Inorganic materials 0.000 description 1
- 238000001179 sorption measurement Methods 0.000 description 1
- 239000003381 stabilizer Substances 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 125000004646 sulfenyl group Chemical group S(*)* 0.000 description 1
- 231100000419 toxicity Toxicity 0.000 description 1
- 230000001988 toxicity Effects 0.000 description 1
- 230000009466 transformation Effects 0.000 description 1
- 230000014616 translation Effects 0.000 description 1
- 210000002700 urine Anatomy 0.000 description 1
- 229940035658 visco-gel Drugs 0.000 description 1
- 239000002699 waste material Substances 0.000 description 1
- 230000002087 whitening effect Effects 0.000 description 1
Landscapes
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
The invention discloses a chlorine dioxide mucous membrane gel and a preparation method thereof. Firstly disodium ethylene diaminetetraacetate is dissolved in purified water, thus obtaining disodium ethylene diaminetetraacetate aqueous solution; one half of the disodium ethylene diaminetetraacetate aqueous solution is taken and warmed, hydroxypropyl methyl cellulose is stirred and dispersed into the warmed disodium ethylene diaminetetraacetate aqueous solution, thus obtaining mixed solution, and cooling to room temperature is carried out, thus obtaining clear mixed solution; the rest half of disodium ethylene diaminetetraacetate aqueous solution is mixed and dissolved with medical grade glycerol and carbomer 934P, and sodium hydroxide aqueous solution is dropwise added, thus obtaining gel base material; and then the clear mixed solution, the gel base material and demand-release chlorine dioxide aqueous solution are mixed, stirred and vacuum defoamed, thus obtaining the chlorine dioxide mucous membrane gel. The invention has rapid, durable and reliable disinfection and sterilization effects, can rapidly and thoroughly kill off all the microorganisms in mouth, nasal cavity, vagina and mucus in anus cavity as well as microorganisms on anus cavity mucosa.
Description
Technical field
The present invention relates to a kind of method for preparing of chlorine dioxide mucosa gel, belong to the disinfection sanitizer technical field.
Background technology
Oral cavity, nasal cavity, vaginal mucosa usually produce ulcer because of the infringement of microorganism, infection, and abnormal flavour takes place easily, stink, make the patient very painful.It is slow and undesirable in the effect of oral mucosa that tradition is used for preparations such as outside sterilization, germ-resistant ethanol, antibiotic, Chinese herbal medicine.
Summary of the invention
One of the object of the invention is to overcome the deficiency that exists in the prior art; A kind of chlorine dioxide mucosa gel and preparation method thereof is provided; Chlorine dioxide mucosa gel sterilization is quick, lasting, reliable; External is coated on the tract mucosa; Can thoroughly kill on oral cavity, nasal cavity, vagina, the anus tract mucosa fast and all microorganisms in the intracavity mucus, desirable to mucosal ulcer, inflammation, the sterilization of infection, the bactericidal effect of oral cavity, nasal cavity, vagina, anus, and deodorization is arranged.
According to technical scheme provided by the invention, comprise the each component of following weight portion in the said chlorine dioxide mucosa gel:
Contain ClO
2Concentration is immediate release property aqueous solution of chlorine dioxide 2 ~ 5 weight portions, carbomer 934 P 0.8 ~ 3 weight portion, hydroxypropyl emthylcellulose 0.5 ~ 1 weight portion, pharmaceutical grade glycerol 10 ~ 15 weight portions, disodiumedetate 0.05 ~ 0.2 weight portion, purified water 70 ~ 90 weight portions of 2000PPM.
Earlier disodiumedetate is dissolved in the purified water, processes disodium ethylene diamine tetra-acetic acid aqueous solution;
Get half intensification of disodium ethylene diamine tetra-acetic acid aqueous solution total amount, hydroxypropyl emthylcellulose stirs and is dispersed in the disodium ethylene diamine tetra-acetic acid aqueous solution after the intensification, obtains mixed solution; Mixed solution obtains clear and bright mixed solution after being cooled to room temperature; Get the half the disodium ethylene diamine tetra-acetic acid aqueous solution of total amount residue and mix with pharmaceutical grade glycerol, carbomer 934 P, fully after the dissolving, the dropping sodium aqueous solution also stirs, and processes the gel base material; Again with clear and bright mixed solution, gel base material and contain ClO
2Concentration is the mixing of immediate release property aqueous solution of chlorine dioxide, stirring, the vacuum defoamation of 2000PPM, processes chlorine dioxide mucosa gel.
The method for preparing of above-mentioned chlorine dioxide mucosa gel comprises the steps:
A, the disodiumedetate of 0.05 ~ 0.2 weight portion is dissolved in the purified water of 70 ~ 90 weight portions, processes disodium ethylene diamine tetra-acetic acid aqueous solution, subsequent use;
B, get disodium ethylene diamine tetra-acetic acid aqueous solution total amount that step a obtains half be warming up to 83 ~ 87 ℃, the hydroxypropyl emthylcellulose of 0.5 ~ 1 weight portion is stirred and is dispersed in the disodium ethylene diamine tetra-acetic acid aqueous solution after the intensification, obtain mixed solution;
C, the mixed solution that step b is obtained are cooled to room temperature and were placed in 3 ~ 5 ℃ the environment 10 ~ 14 hours, obtain clear and bright mixed solution;
D, get the half the disodium ethylene diamine tetra-acetic acid aqueous solution of step a total amount residue and mix with the pharmaceutical grade glycerol of 10 ~ 15 weight portions, the carbomer 934 P of 0.8 ~ 3 weight portion; Fully after the dissolving; The dropping concentration expressed in percentage by weight is 15% sodium hydrate aqueous solution and stirs; The gel base material is processed in regulator solution PH to 6.5 ~ 7.5;
E, the clear and bright mixed solution that step c is obtained, gel base material that steps d obtains, contain ClO
2Concentration is 2 ~ 5 weight portion mixing of immediate release property aqueous solution of chlorine dioxide, stirring, the vacuum defoamation of 2000PPM, processes chlorine dioxide mucosa gel; Said vacuum be-0.06 MPa～-0.08MPa.
That chlorine dioxide mucosa gel that the present invention makes needs is airtight, lucifuge, the shady and cool preservation.
Chlorine dioxide mucosa gel sterilization of the present invention is quick, lasting, reliable; External is coated on the tract mucosa; Can thoroughly kill on oral cavity, nasal cavity, vagina, the anus tract mucosa fast and all microorganisms in the intracavity mucus comprise antibacterial, virus, fungus, chlamydia, mycoplasma, desirable to mucosal ulcer, inflammation, the sterilization of infection, the bactericidal effect of oral cavity, nasal cavity, vagina, anus.Can prevent diseases such as oral ulcer, rhinitis, vaginitis, pelvic inflammatory disease, anal ulcer, and deodorization is arranged.
The specific embodiment
Below in conjunction with specific embodiment the present invention is described further.
Embodiment 1
A, the disodiumedetate of 0.05 weight portion is dissolved in the purified water of 70 weight portions, processes disodium ethylene diamine tetra-acetic acid aqueous solution, subsequent use;
B, get disodium ethylene diamine tetra-acetic acid aqueous solution total amount that step a obtains half be warming up to 83 ℃, the hydroxypropyl emthylcellulose of 1 weight portion is stirred and is dispersed in the disodium ethylene diamine tetra-acetic acid aqueous solution after the intensification, obtain mixed solution;
C, the mixed solution that step b is obtained are cooled to room temperature and were placed in 3 ℃ the environment 10 hours, obtain clear and bright mixed solution;
D, get the half the disodium ethylene diamine tetra-acetic acid aqueous solution of step a total amount residue and mix with the pharmaceutical grade glycerol of 10 weight portions, the carbomer 934 P of 0.8 weight portion; Fully after the dissolving; The dropping concentration expressed in percentage by weight is 15% sodium hydrate aqueous solution and stirs; The gel base material is processed in regulator solution PH to 6.5 ~ 7.5;
E, the clear and bright mixed solution that step c is obtained, gel base material that steps d obtains, contain ClO
2Concentration is the 2 weight portion mixing of immediate release property aqueous solution of chlorine dioxide, stirring, the vacuum defoamation of 2000PPM, processes chlorine dioxide mucosa gel; Said vacuum be-0.06 MPa～-0.08MPa.
In the chlorine dioxide mucosa gel that makes, contain ClO
2Concentration is immediate release property aqueous solution of chlorine dioxide 2 weight portions, carbomer 934 P 0.8 weight portion, hydroxypropyl emthylcellulose 1 weight portion, pharmaceutical grade glycerol 10 weight portions, disodiumedetate 0.05 weight portion, purified water 70 weight portions of 2000PPM.
The chlorine dioxide mucosa gel that embodiment 1 obtains carries out extracorporeal bacteria inhibitor test and shows, in 10 seconds, kills bacillus pyocyaneus, Salmonella choleraesuls; Killed escherichia coli, staphylococcus aureus, gonorrhea diplococcus, treponema pallidum, trichomonal vaginitis, streptococcus faecalis in 2 minutes; Killing rate reaches 99.99%.Killed HbsAg hepatitis virus, bacillus subtilis black variety gemma in 5 minutes, killing rate reaches 100%.To the bacteriostatic test of mycete the time; Compared aqueous solution of chlorine dioxide and bacteriostasis time of the present invention: around the transparent inhibition zone, after cultivating in 24 hours, answering of aqueous solution of chlorine dioxide fogs again; And the present invention is still transparent; Show that the antibacterial time of thing of the present invention obviously prolongs, this is because the present invention in the same first killing microorganisms with aqueous solution of chlorine dioxide at the beginning, and then slowly discharges chlorine dioxide and continues to take place dauer effect; And the chlorine dioxide in the aqueous solution of chlorine dioxide has been participated in reaction in whole releases at the very start.
Embodiment 2
A, the disodiumedetate of 0.2 weight portion is dissolved in the purified water of 90 weight portions, processes disodium ethylene diamine tetra-acetic acid aqueous solution, subsequent use;
B, get disodium ethylene diamine tetra-acetic acid aqueous solution total amount that step a obtains half be warming up to 85 ℃, the hydroxypropyl emthylcellulose of 0.5 weight portion is stirred and is dispersed in the disodium ethylene diamine tetra-acetic acid aqueous solution after the intensification, obtain mixed solution;
C, the mixed solution that step b is obtained are cooled to room temperature and were placed in 5 ℃ the environment 14 hours, obtain clear and bright mixed solution;
D, get the half the disodium ethylene diamine tetra-acetic acid aqueous solution of step a total amount residue and mix with the pharmaceutical grade glycerol of 15 weight portions, the carbomer 934 P of 3 weight portions; Fully after the dissolving; The dropping concentration expressed in percentage by weight is 15% sodium hydrate aqueous solution and stirs; The gel base material is processed in regulator solution PH to 6.5 ~ 7.5;
E, the clear and bright mixed solution that step c is obtained, gel base material that steps d obtains, contain ClO
2Concentration is immediate release property aqueous solution of chlorine dioxide totally 5 weight portion mixing, stirring, the vacuum defoamation of 2000PPM, processes chlorine dioxide mucosa gel.Said vacuum be-0.06 MPa～-0.08MPa.
In the chlorine dioxide mucosa gel that makes, contain ClO
2Concentration is immediate release property aqueous solution of chlorine dioxide 5 weight portions, carbomer 934 P 3 weight portions, hydroxypropyl emthylcellulose 0.5 weight portion, pharmaceutical grade glycerol 15 weight portions, disodiumedetate 0.2 weight portion, purified water 90 weight portions of 2000PPM.
The chlorine dioxide mucosa gel that embodiment 2 obtains carries out extracorporeal bacteria inhibitor test and shows, in 10 seconds, kills bacillus pyocyaneus, Salmonella choleraesuls; Killed escherichia coli, staphylococcus aureus, gonorrhea diplococcus, treponema pallidum, trichomonal vaginitis, streptococcus faecalis in 2 minutes; Killing rate reaches 99.99%.Killed HbsAg hepatitis virus, bacillus subtilis black variety gemma in 5 minutes, killing rate reaches 100%.To the bacteriostatic test of mycete the time; Compared aqueous solution of chlorine dioxide and bacteriostasis time of the present invention: around the transparent inhibition zone, after cultivating in 24 hours, answering of aqueous solution of chlorine dioxide fogs again; And the present invention is still transparent; Show that the antibacterial time of thing of the present invention obviously prolongs, this is because the present invention in the same first killing microorganisms with aqueous solution of chlorine dioxide at the beginning, and then slowly discharges chlorine dioxide and continues to take place dauer effect; And the chlorine dioxide in the aqueous solution of chlorine dioxide has been participated in reaction in whole releases at the very start.
Embodiment 3
A, the disodiumedetate of 0.15 weight portion is dissolved in the purified water of 85 weight portions, processes disodium ethylene diamine tetra-acetic acid aqueous solution, subsequent use;
B, get disodium ethylene diamine tetra-acetic acid aqueous solution total amount that step a obtains half be warming up to 87 ℃, the hydroxypropyl emthylcellulose of 0.8 weight portion is stirred and is dispersed in the disodium ethylene diamine tetra-acetic acid aqueous solution after the intensification, obtain mixed solution;
C, the mixed solution that step b is obtained are cooled to room temperature and were placed in 4 ℃ the environment totally 12 hours, obtain clear and bright mixed solution;
D, get the half the disodium ethylene diamine tetra-acetic acid aqueous solution of step a total amount residue and mix with the pharmaceutical grade glycerol of 12 weight portions, the carbomer 934 P of 1.5 weight portions; Fully after the dissolving; The dropping concentration expressed in percentage by weight is 15% sodium hydrate aqueous solution and stirs; The gel base material is processed in regulator solution PH to 6.5 ~ 7.5;
E, the clear and bright mixed solution that step c is obtained, gel base material that steps d obtains, contain ClO
2Concentration is immediate release property aqueous solution of chlorine dioxide totally 3 weight portion mixing, stirring, the vacuum defoamation of 2000PPM, processes chlorine dioxide mucosa gel.Said vacuum be-0.06 MPa～-0.08MPa.
In the chlorine dioxide mucosa gel that makes, contain ClO
2Concentration is immediate release property aqueous solution of chlorine dioxide 3 weight portions, carbomer 934 P 1.5 weight portions, hydroxypropyl emthylcellulose totally 0.8 weight portion, pharmaceutical grade glycerol 12 weight portions, disodiumedetate 0.15 weight portion, purified water 85 weight portions of 2000PPM.
The chlorine dioxide mucosa gel that embodiment 3 obtains carries out extracorporeal bacteria inhibitor test and shows, in 10 seconds, kills bacillus pyocyaneus, Salmonella choleraesuls; Killed escherichia coli, staphylococcus aureus, gonorrhea diplococcus, treponema pallidum, trichomonal vaginitis, streptococcus faecalis in 2 minutes; Killing rate reaches 99.99%.Killed HbsAg hepatitis virus, bacillus subtilis black variety gemma in 5 minutes, killing rate reaches 100%.To the bacteriostatic test of mycete the time; Compared aqueous solution of chlorine dioxide and bacteriostasis time of the present invention: around the transparent inhibition zone, after cultivating in 24 hours, answering of aqueous solution of chlorine dioxide fogs again; And the present invention is still transparent; Show that the antibacterial time of thing of the present invention obviously prolongs, this is because the present invention in the same first killing microorganisms with aqueous solution of chlorine dioxide at the beginning, and then slowly discharges chlorine dioxide and continues to take place dauer effect; And the chlorine dioxide in the aqueous solution of chlorine dioxide has been participated in reaction in whole releases at the very start.
The present invention utilizes international present up-to-date disinfection sanitizer instant-free property aqueous solution of chlorine dioxide, processes the mucosa gel in conjunction with macromolecular material carbomer (Carbomer) 934P to the mucosa strong adhesion.Coat the tract mucomembranous surface and the tooth gingival surface of oral cavity, nasal cavity, vagina, anus, reach quick, persistent antibacterial, sterilization, deodorization, be used for diseases such as anti-treating dental ulcer, rhinitis, vaginitis, pelvic inflammatory disease, anal ulcer.Being coated on dental surface can bleaching, antibacterial, sterilization, makes teeth whitening, and control periodontitis, gingivitis are eliminated mouth odor.
Chlorine dioxide mucosa gel sterilizing has following advantage:
1. quick and durable;
2. safety non-toxic;
3. broad-spectrum high efficacy;
4. antibacterial, sterilization, bleaching, the multiple function of deodorization;
5. receive environment (like temperature, pH value, Organic substance etc.) influence when using hardly.Chlorine dioxide pair cell wall has stronger adsorption penetration power; The oxidizing microorganisms cell includes enzyme and DNA, the RNA of sulfenyl effectively; The protein synthesis that suppresses microorganism fast; Directly kill microorganisms is killed all microorganisms such as comprising bacterial propagule, bacterial spore, fungus, mycobacteria, virus, mycoplasma, chlamydia, high-efficiency broad spectrum.
6. chlorine dioxide has bleaching, deodorization functions simultaneously, can carry out oxidation bleaching because of the pigmented spots that the Semen Arecae of smoking, drink tea, chew causes to dental surface in the prescription.In addition, can the oxidation interval of tooth, surface and the intermastoid waste matter of the big flower bud of tongue, eliminate abnormal flavour, stink.
After disinfection by chlorine dioxide, antibacterial, bleaching, the deodorization, Degradation and Transformation is carbon dioxide, water, sodium chloride.
But approach such as the suction of chlorine dioxide nationality, skin contact, eat with mucosa get into human body.Can be absorbed by digestive tract very soon after mouth is dirty, and in 1 hour, reach the highest blood level.Wherein 43% in 72 hours, discharge through urine or feces.The saturation solubility of chlorine dioxide in aqueous solution is 3000mg/L; Also be 3000PPM, the instant-free property aqueous solution of chlorine dioxide that the present invention uses contains chlorine dioxide and is 2000PPM, uses in the thing of the present invention; The content of chlorine dioxide is only below the 400PPM, and is safe in utilization, actual nontoxic.
After cooperating carbomer 934 P to process gel, the chlorine dioxide that can make rests on tract mucomembranous surface and tooth, gingival surface time and prolongs greatly, makes to render a service to take place lastingly, improves effect.The viscosity that carbomer 934 P has increased system becomes gel, in the stronger mechanical adhesion power of tract mucomembranous surface, is prolonged the time of staying; In addition, better is that carbomer 934 P has very strong bioadhesive; The macromolecular chain that mainly is carbomer 934 P can twine with mucosa glycoprotein macromole each other; Afterwards with the glycoprotein oligonucleotide chain on the residual sugar base form hydrogen bond, produce stronger viscogel RF, and keep long mucosal bioadhesive; The carbomer gel aqueous systems has the medicament slow release effect, and the chlorine dioxide in the gel slowly discharges, and makes sterilization, antibacterial, bleaching, the deodorization of chlorine dioxide effective lastingly.So it is suitable especially to select for use carbomer 934 P to process the mucosa gel in the prescription.
After carbomer 934 P swells in water, regulate more than the PH to 5, can make a large amount of carboxyls that contain in the molecule dissociate electronegative with dripping like aqueous slkalis such as sodium hydroxide, oxyammonia, triethanolamine; Like charges repels each other, and macromole is fully stretched, and volume increases more than 1000 times; RF is filled the air in formation; Viscosity increases sharply, and is the viscosity clear solution during carbomer 934 P low concentration, and concentration forms translucent gels when big.The above nearly neutrality of solution PH to 5 is heightened in a small amount of dropping of 15% concentration hydrogen aqueous solution of sodium oxide just makes formula solution become gel.
Carbomer 934 P and hydroxypropyl methyl fiber table are used, and gel adhesive force is better.
Use carbomer 934 P to prepare mucosa gel of the present invention and be hydrophilic gel; Easy, the steady quality of method for preparing; Do not need heating condition when preparing at last, be more suitable for immediate release property aqueous solution of chlorine dioxide volatile, poor heat stability and process chlorine dioxide mucosa gel of the present invention.
Carbomer 934 P toxicity is very low, and " P " is to use the safer product in the mucosa product in the trade name.
Even metal ions such as the ferrum, manganese of trace also can catalysis chlorine dioxide generation oxidation reaction, make antibacterial, sterilization, bleaching, the deodorization decay of chlorine dioxide, in product preservation process, should avoid taking place.Add efficient metal ionic complexing agent disodiumedetate as stabilizing agent; It can generate firm complex with the most metal ions except that alkali metal; Eliminate the influence that metal ion causes, it is stable that chlorine dioxide mucosa gel of the present invention is preserved.
In addition, light, heat, loss also are to cause chlorine dioxide to render a service the inducement of decay.So chlorine dioxide mucosa gel of the present invention also should be preserved under airtight, lucifuge, shady and cool condition.
The instant-free property aqueous solution of chlorine dioxide that adopts among the present invention is by production of units such as the quartzy Environmental Protection Technology Co., Ltd in Shenzhen.
Carbomer 934 P is the medical auxiliary materials of using always, can conveniently buy.
Claims (1)
1. the method for preparing of a chlorine dioxide mucosa gel is characterized in that this method for preparing comprises the steps:
A, the disodiumedetate of 0.05 ~ 0.2 weight portion is dissolved in the purified water of 70 ~ 90 weight portions, processes disodium ethylene diamine tetra-acetic acid aqueous solution, subsequent use;
B, get disodium ethylene diamine tetra-acetic acid aqueous solution total amount that step a obtains half be warming up to 83 ~ 87 ℃, the hydroxypropyl emthylcellulose of 0.5 ~ 1 weight portion is stirred and is dispersed in the disodium ethylene diamine tetra-acetic acid aqueous solution after the intensification, obtain mixed solution;
C, the mixed solution that step b is obtained are cooled to room temperature and were placed in 3 ~ 5 ℃ the environment 10 ~ 14 hours, obtain clear and bright mixed solution;
D, get the half the disodium ethylene diamine tetra-acetic acid aqueous solution of step a total amount residue and mix with the pharmaceutical grade glycerol of 10 ~ 15 weight portions, the carbomer 934 P of 0.8 ~ 3 weight portion; Fully after the dissolving; The dropping concentration expressed in percentage by weight is 15% sodium hydrate aqueous solution totally 0.1 ~ 0.5 weight portion and stirring, processes the gel base material;
E, the clear and bright mixed solution that step c is obtained, gel base material that steps d obtains, contain ClO
2Concentration is 2 ~ 5 weight portion mixing of immediate release property aqueous solution of chlorine dioxide, stirring, the vacuum defoamation of 2000PPM, processes chlorine dioxide mucosa gel; Said vacuum be-0.06 MPa～-0.08MPa.
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| CN111264556A (en) * | 2020-03-10 | 2020-06-12 | 宋健 | Gel for chlorine dioxide air disinfection and preparation method thereof |
| CN112970775A (en) * | 2021-01-26 | 2021-06-18 | 孙秀会 | Formula, preparation process and preparation device of low-temperature hypochlorous acid disinfectant |
| CN113396901B (en) * | 2021-06-25 | 2022-11-04 | 新乡市康大消毒剂有限公司 | Gel for slowly releasing chlorine dioxide and preparation method thereof |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1222345A (en) * | 1997-12-01 | 1999-07-14 | 段建涛 | Gargle containing chlorine dioxide |
| CN101669518A (en) * | 2009-09-30 | 2010-03-17 | 北京欧凯纳斯科技有限公司 | Germicidal antiviral composite containing chlorine dioxide |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1222345A (en) * | 1997-12-01 | 1999-07-14 | 段建涛 | Gargle containing chlorine dioxide |
| CN101669518A (en) * | 2009-09-30 | 2010-03-17 | 北京欧凯纳斯科技有限公司 | Germicidal antiviral composite containing chlorine dioxide |
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