CN101972271A - Chlorine dioxide mucous membrane gel and preparation method thereof - Google Patents
Chlorine dioxide mucous membrane gel and preparation method thereof Download PDFInfo
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Abstract
The invention discloses a chlorine dioxide mucous membrane gel and a preparation method thereof. Firstly disodium ethylene diaminetetraacetate is dissolved in purified water, thus obtaining disodium ethylene diaminetetraacetate aqueous solution; one half of the disodium ethylene diaminetetraacetate aqueous solution is taken and warmed, hydroxypropyl methyl cellulose is stirred and dispersed into the warmed disodium ethylene diaminetetraacetate aqueous solution, thus obtaining mixed solution, and cooling to room temperature is carried out, thus obtaining clear mixed solution; the rest half of disodium ethylene diaminetetraacetate aqueous solution is mixed and dissolved with medical grade glycerol and carbomer 934P, and sodium hydroxide aqueous solution is dropwise added, thus obtaining gel base material; and then the clear mixed solution, the gel base material and demand-release chlorine dioxide aqueous solution are mixed, stirred and vacuum defoamed, thus obtaining the chlorine dioxide mucous membrane gel. The invention has rapid, durable and reliable disinfection and sterilization effects, can rapidly and thoroughly kill off all the microorganisms in mouth, nasal cavity, vagina and mucus in anus cavity as well as microorganisms on anus cavity mucosa.
Description
Technical field
The present invention relates to a kind of preparation method of chlorine dioxide mucosa gel, belong to the disinfection sanitizer technical field.
Background technology
Oral cavity, nasal cavity, vaginal mucosa usually produce ulcer because of the infringement of microorganism, infection, and abnormal flavour takes place easily, stink, make the patient very painful.It is slow and undesirable in the effect of oral mucosa that tradition is used for preparations such as outside sterilization, germ-resistant ethanol, antibiotic, Chinese herbal medicine.
Summary of the invention
One of purpose of the present invention is to overcome the deficiencies in the prior art, a kind of chlorine dioxide mucosa gel and preparation method thereof is provided, chlorine dioxide mucosa gel sterilization is quick, lasting, reliable, external is coated on the tract mucosa, can thoroughly kill on oral cavity, nasal cavity, vagina, the anus tract mucosa fast and all microorganisms in the intracavity mucus, to mucosal ulcer, inflammation, the sterilization of infection, the bactericidal effect ideal of oral cavity, nasal cavity, vagina, anus, and deodorization is arranged.
According to technical scheme provided by the invention, comprise the each component of following weight portion in the described chlorine dioxide mucosa gel:
Contain ClO
2Concentration is immediate release property aqueous solution of chlorine dioxide 2 ~ 5 weight portions, carbomer 934 P 0.8 ~ 3 weight portion, hydroxypropyl emthylcellulose 0.5 ~ 1 weight portion, pharmaceutical grade glycerol 10 ~ 15 weight portions, disodiumedetate 0.05 ~ 0.2 weight portion, purified water 70 ~ 90 weight portions of 2000PPM.
Earlier disodiumedetate is dissolved in the purified water, makes disodium ethylene diamine tetra-acetic acid aqueous solution;
Half of getting the disodium ethylene diamine tetra-acetic acid aqueous solution total amount heats up, and hydroxypropyl emthylcellulose stirs and is dispersed in the disodium ethylene diamine tetra-acetic acid aqueous solution after the intensification, obtains mixed solution; Mixed solution obtains clear and bright mixed solution after being cooled to room temperature; Get the disodium ethylene diamine tetra-acetic acid aqueous solution that total amount remains half and mix with pharmaceutical grade glycerol, carbomer 934 P, fully after the dissolving, the dropping sodium aqueous solution also stirs, and makes the gel base material; Again with clear and bright mixed solution, gel base material and contain ClO
2Concentration is the mixing of immediate release property aqueous solution of chlorine dioxide, stirring, the vacuum defoamation of 2000PPM, makes chlorine dioxide mucosa gel.
The preparation method of above-mentioned chlorine dioxide mucosa gel comprises the steps:
A, the disodiumedetate of 0.05 ~ 0.2 weight portion is dissolved in the purified water of 70 ~ 90 weight portions, makes disodium ethylene diamine tetra-acetic acid aqueous solution, standby;
B, get disodium ethylene diamine tetra-acetic acid aqueous solution total amount that step a obtains half be warming up to 83 ~ 87 ℃, the hydroxypropyl emthylcellulose of 0.5 ~ 1 weight portion is stirred and is dispersed in the disodium ethylene diamine tetra-acetic acid aqueous solution after the intensification, obtain mixed solution;
C, the mixed solution that step b is obtained are cooled to room temperature and were placed in 3 ~ 5 ℃ the environment 10 ~ 14 hours, obtain clear and bright mixed solution;
D, get step a total amount and remain the disodium ethylene diamine tetra-acetic acid aqueous solution of half and mix with the pharmaceutical grade glycerol of 10 ~ 15 weight portions, the carbomer 934 P of 0.8 ~ 3 weight portion, fully after the dissolving, the dropping concentration expressed in percentage by weight is 15% sodium hydrate aqueous solution and stirs, the gel base material is made in regulator solution PH to 6.5 ~ 7.5;
E, the clear and bright mixed solution that step c is obtained, gel base material that steps d obtains, contain ClO
2Concentration is 2 ~ 5 weight portion mixing of immediate release property aqueous solution of chlorine dioxide, stirring, the vacuum defoamation of 2000PPM, makes chlorine dioxide mucosa gel; Described vacuum be-0.06 MPa～-0.08MPa.
That chlorine dioxide mucosa gel that the present invention makes needs is airtight, lucifuge, the shady and cool preservation.
Chlorine dioxide mucosa gel sterilization of the present invention is quick, lasting, reliable, external is coated on the tract mucosa, can thoroughly kill on oral cavity, nasal cavity, vagina, the anus tract mucosa fast and all microorganisms in the intracavity mucus comprise antibacterial, virus, fungus, chlamydia, mycoplasma, to mucosal ulcer, inflammation, the sterilization of infection, the bactericidal effect ideal of oral cavity, nasal cavity, vagina, anus.Can prevent diseases such as oral ulcer, rhinitis, vaginitis, pelvic inflammatory disease, anal ulcer, and deodorization is arranged.
The specific embodiment
The invention will be further described below in conjunction with specific embodiment.
Embodiment 1
A, the disodiumedetate of 0.05 weight portion is dissolved in the purified water of 70 weight portions, makes disodium ethylene diamine tetra-acetic acid aqueous solution, standby;
B, get disodium ethylene diamine tetra-acetic acid aqueous solution total amount that step a obtains half be warming up to 83 ℃, the hydroxypropyl emthylcellulose of 1 weight portion is stirred and is dispersed in the disodium ethylene diamine tetra-acetic acid aqueous solution after the intensification, obtain mixed solution;
C, the mixed solution that step b is obtained are cooled to room temperature and were placed in 3 ℃ the environment 10 hours, obtain clear and bright mixed solution;
D, get step a total amount and remain the disodium ethylene diamine tetra-acetic acid aqueous solution of half and mix with the pharmaceutical grade glycerol of 10 weight portions, the carbomer 934 P of 0.8 weight portion, fully after the dissolving, the dropping concentration expressed in percentage by weight is 15% sodium hydrate aqueous solution and stirs, the gel base material is made in regulator solution PH to 6.5 ~ 7.5;
E, the clear and bright mixed solution that step c is obtained, gel base material that steps d obtains, contain ClO
2Concentration is the 2 weight portion mixing of immediate release property aqueous solution of chlorine dioxide, stirring, the vacuum defoamation of 2000PPM, makes chlorine dioxide mucosa gel; Described vacuum be-0.06 MPa～-0.08MPa.
In the chlorine dioxide mucosa gel that makes, contain ClO
2Concentration is immediate release property aqueous solution of chlorine dioxide 2 weight portions, carbomer 934 P 0.8 weight portion, hydroxypropyl emthylcellulose 1 weight portion, pharmaceutical grade glycerol 10 weight portions, disodiumedetate 0.05 weight portion, purified water 70 weight portions of 2000PPM.
The chlorine dioxide mucosa gel that embodiment 1 obtains carries out extracorporeal bacteria inhibitor test and shows, kills bacillus pyocyaneus, Salmonella choleraesuls in 10 seconds; Killed escherichia coli, staphylococcus aureus, gonorrhea diplococcus, treponema pallidum, trichomonal vaginitis, streptococcus faecalis in 2 minutes; Killing rate reaches 99.99%.Killed HbsAg hepatitis virus, bacillus subtilis black variety gemma in 5 minutes, killing rate reaches 100%.To the bacteriostatic test of mycete the time, aqueous solution of chlorine dioxide and bacteriostasis time of the present invention have been compared: around the transparent inhibition zone, after cultivating in 24 hours again, answering of aqueous solution of chlorine dioxide fogs, and the present invention is still transparent, show that the antibacterial time of thing of the present invention obviously prolongs, this is because the present invention in the same first killing microorganisms with aqueous solution of chlorine dioxide at the beginning, and then slowly discharges chlorine dioxide and continues to take place dauer effect; And the chlorine dioxide in the aqueous solution of chlorine dioxide has participated in reaction in whole releases at the very start.
Embodiment 2
A, the disodiumedetate of 0.2 weight portion is dissolved in the purified water of 90 weight portions, makes disodium ethylene diamine tetra-acetic acid aqueous solution, standby;
B, get disodium ethylene diamine tetra-acetic acid aqueous solution total amount that step a obtains half be warming up to 85 ℃, the hydroxypropyl emthylcellulose of 0.5 weight portion is stirred and is dispersed in the disodium ethylene diamine tetra-acetic acid aqueous solution after the intensification, obtain mixed solution;
C, the mixed solution that step b is obtained are cooled to room temperature and were placed in 5 ℃ the environment 14 hours, obtain clear and bright mixed solution;
D, get step a total amount and remain the disodium ethylene diamine tetra-acetic acid aqueous solution of half and mix with the pharmaceutical grade glycerol of 15 weight portions, the carbomer 934 P of 3 weight portions, fully after the dissolving, the dropping concentration expressed in percentage by weight is 15% sodium hydrate aqueous solution and stirs, the gel base material is made in regulator solution PH to 6.5 ~ 7.5;
E, the clear and bright mixed solution that step c is obtained, gel base material that steps d obtains, contain ClO
2Concentration is immediate release property aqueous solution of chlorine dioxide totally 5 weight portion mixing, stirring, the vacuum defoamation of 2000PPM, makes chlorine dioxide mucosa gel.Described vacuum be-0.06 MPa～-0.08MPa.
In the chlorine dioxide mucosa gel that makes, contain ClO
2Concentration is immediate release property aqueous solution of chlorine dioxide 5 weight portions, carbomer 934 P 3 weight portions, hydroxypropyl emthylcellulose 0.5 weight portion, pharmaceutical grade glycerol 15 weight portions, disodiumedetate 0.2 weight portion, purified water 90 weight portions of 2000PPM.
The chlorine dioxide mucosa gel that embodiment 2 obtains carries out extracorporeal bacteria inhibitor test and shows, kills bacillus pyocyaneus, Salmonella choleraesuls in 10 seconds; Killed escherichia coli, staphylococcus aureus, gonorrhea diplococcus, treponema pallidum, trichomonal vaginitis, streptococcus faecalis in 2 minutes; Killing rate reaches 99.99%.Killed HbsAg hepatitis virus, bacillus subtilis black variety gemma in 5 minutes, killing rate reaches 100%.To the bacteriostatic test of mycete the time, aqueous solution of chlorine dioxide and bacteriostasis time of the present invention have been compared: around the transparent inhibition zone, after cultivating in 24 hours again, answering of aqueous solution of chlorine dioxide fogs, and the present invention is still transparent, show that the antibacterial time of thing of the present invention obviously prolongs, this is because the present invention in the same first killing microorganisms with aqueous solution of chlorine dioxide at the beginning, and then slowly discharges chlorine dioxide and continues to take place dauer effect; And the chlorine dioxide in the aqueous solution of chlorine dioxide has participated in reaction in whole releases at the very start.
Embodiment 3
A, the disodiumedetate of 0.15 weight portion is dissolved in the purified water of 85 weight portions, makes disodium ethylene diamine tetra-acetic acid aqueous solution, standby;
B, get disodium ethylene diamine tetra-acetic acid aqueous solution total amount that step a obtains half be warming up to 87 ℃, the hydroxypropyl emthylcellulose of 0.8 weight portion is stirred and is dispersed in the disodium ethylene diamine tetra-acetic acid aqueous solution after the intensification, obtain mixed solution;
C, the mixed solution that step b is obtained are cooled to room temperature and were placed in 4 ℃ the environment totally 12 hours, obtain clear and bright mixed solution;
D, get step a total amount and remain the disodium ethylene diamine tetra-acetic acid aqueous solution of half and mix with the pharmaceutical grade glycerol of 12 weight portions, the carbomer 934 P of 1.5 weight portions, fully after the dissolving, the dropping concentration expressed in percentage by weight is 15% sodium hydrate aqueous solution and stirs, the gel base material is made in regulator solution PH to 6.5 ~ 7.5;
E, the clear and bright mixed solution that step c is obtained, gel base material that steps d obtains, contain ClO
2Concentration is immediate release property aqueous solution of chlorine dioxide totally 3 weight portion mixing, stirring, the vacuum defoamation of 2000PPM, makes chlorine dioxide mucosa gel.Described vacuum be-0.06 MPa～-0.08MPa.
In the chlorine dioxide mucosa gel that makes, contain ClO
2Concentration is immediate release property aqueous solution of chlorine dioxide 3 weight portions, carbomer 934 P 1.5 weight portions, hydroxypropyl emthylcellulose totally 0.8 weight portion, pharmaceutical grade glycerol 12 weight portions, disodiumedetate 0.15 weight portion, purified water 85 weight portions of 2000PPM.
The chlorine dioxide mucosa gel that embodiment 3 obtains carries out extracorporeal bacteria inhibitor test and shows, kills bacillus pyocyaneus, Salmonella choleraesuls in 10 seconds; Killed escherichia coli, staphylococcus aureus, gonorrhea diplococcus, treponema pallidum, trichomonal vaginitis, streptococcus faecalis in 2 minutes; Killing rate reaches 99.99%.Killed HbsAg hepatitis virus, bacillus subtilis black variety gemma in 5 minutes, killing rate reaches 100%.To the bacteriostatic test of mycete the time, aqueous solution of chlorine dioxide and bacteriostasis time of the present invention have been compared: around the transparent inhibition zone, after cultivating in 24 hours again, answering of aqueous solution of chlorine dioxide fogs, and the present invention is still transparent, show that the antibacterial time of thing of the present invention obviously prolongs, this is because the present invention in the same first killing microorganisms with aqueous solution of chlorine dioxide at the beginning, and then slowly discharges chlorine dioxide and continues to take place dauer effect; And the chlorine dioxide in the aqueous solution of chlorine dioxide has participated in reaction in whole releases at the very start.
The present invention utilizes international present up-to-date disinfection sanitizer instant-free aqueous solution of chlorine dioxide, makes the mucosa gel in conjunction with macromolecular material carbomer (Carbomer) 934P to the mucosa strong adhesion.Coat the tract mucomembranous surface and the tooth gingival surface of oral cavity, nasal cavity, vagina, anus, reach quick, persistent sterilization, sterilization, deodorization, be used for diseases such as anti-treating dental ulcer, rhinitis, vaginitis, pelvic inflammatory disease, anal ulcer.Be coated on dental surface and can bleach, sterilize, sterilize, make teeth whitening, control periodontitis, gingivitis are eliminated mouth odor.
Chlorine dioxide mucosa gel sterilizing has following advantage:
1. quick and durable;
2. safety non-toxic;
3. broad-spectrum high efficacy;
4. sterilization, sterilization, bleaching, the multiple function of deodorization;
5. be subjected to environment (as temperature, pH value, Organic substance etc.) influence when using hardly.Chlorine dioxide pair cell wall has stronger adsorption penetration power, the oxidizing microorganisms cell includes enzyme and DNA, the RNA of sulfenyl effectively, the protein synthesis that suppresses microorganism fast, direct kill microorganisms, kill all microorganisms such as comprising bacterial propagule, bacterial spore, fungus, mycobacteria, virus, mycoplasma, chlamydia, high-efficiency broad spectrum.
6. chlorine dioxide has bleaching, deodorization functions simultaneously, can carry out oxidation bleaching because of the pigmented spots that the Semen Arecae of smoking, drink tea, chew causes to dental surface in the prescription.In addition, can the oxidation interval of tooth, surface and the intermastoid waste matter of the big flower bud of tongue, eliminate abnormal flavour, stink.
After disinfection by chlorine dioxide, sterilization, bleaching, the deodorization, Degradation and Transformation is carbon dioxide, water, sodium chloride.
But approach such as the suction of chlorine dioxide nationality, skin contact, eat with mucosa enter human body.Can be absorbed very soon after mouth is dirty, and in 1 hour, reach the highest blood level by digestive tract.Wherein 43% in 72 hours, discharge through urine or feces.The saturation solubility of chlorine dioxide in aqueous solution is 3000mg/L, also be 3000PPM, the instant-free aqueous solution of chlorine dioxide that the present invention uses contains chlorine dioxide and is 2000PPM, uses in the thing of the present invention, the content of chlorine dioxide is only below the 400PPM, and is safe in utilization, actual nontoxic.
After cooperating carbomer 934 P to make gel, the chlorine dioxide that can make rests on tract mucomembranous surface and tooth, gingival surface time and prolongs greatly, makes to render a service to take place lastingly, improves effect.The viscosity that carbomer 934 P has increased system becomes gel, in the stronger mechanical adhesion power of tract mucomembranous surface, the time of staying is prolonged, in addition, better is that carbomer 934 P has very strong bioadhesive, the macromolecular chain that mainly is carbomer 934 P can twine mutually with mucosa glycoprotein macromole, afterwards with the glycoprotein oligonucleotide chain on the residual sugar base form hydrogen bond, produce stronger viscogel network structure, and keep long mucosal bioadhesive; The carbomer gel aqueous systems has the medicament slow release effect, and the chlorine dioxide in the gel slowly discharges, and makes sterilization, sterilization, bleaching, the deodorization of chlorine dioxide effective lastingly.So it is suitable especially to select for use carbomer 934 P to make the mucosa gel in the prescription.
After carbomer 934 P swells in water, regulate more than the PH to 5 with dripping as aqueous slkalis such as sodium hydroxide, oxyammonia, triethanolamine, can make a large amount of carboxyls that contain in the molecule dissociate electronegative, like charges repels each other, and macromole is fully stretched, and volume increases more than 1000 times, network structure is filled the air in formation, viscosity increases sharply, and is the viscosity clear solution during carbomer 934 P low concentration, and concentration forms translucent gels when big.The above nearly neutrality of solution PH to 5 is heightened in a small amount of dropping of 15% concentration hydrogen aqueous solution of sodium oxide just makes formula solution become gel.
Carbomer 934 P and hydroxypropyl methyl fiber table are used, and gel adhesive force is better.
Preparing mucosa gel of the present invention with carbomer 934 P is hydrophilic gel, easy, the steady quality of preparation method, do not need heating condition when preparing at last, be more suitable for immediate release property aqueous solution of chlorine dioxide volatile, poor heat stability and make chlorine dioxide mucosa gel of the present invention.
Carbomer 934 P toxicity is very low, and " P " is to use the safer product in the mucosa product in the trade name.
Even metal ions such as the ferrum, manganese of trace also can catalysis chlorine dioxide generation oxidation reaction, make sterilization, sterilization, bleaching, the deodorization decay of chlorine dioxide, in product preservation process, should avoid taking place.Add efficient metal ionic complexing agent disodiumedetate as stabilizing agent, it can generate firm complex with the most metal ions except that alkali metal, eliminate the influence that metal ion causes, it is stable that chlorine dioxide mucosa gel of the present invention is preserved.
In addition, light, heat, loss also are to cause chlorine dioxide to render a service the inducement of decay.So chlorine dioxide mucosa gel of the present invention also should be preserved under airtight, lucifuge, shady and cool condition.
The instant-free aqueous solution of chlorine dioxide that adopts among the present invention is by production of units such as the quartzy Environmental Protection Technology Co., Ltd in Shenzhen.
Carbomer 934 P is the medical auxiliary materials of using always, can conveniently buy.
Claims (2)
1. chlorine dioxide mucosa gel is characterized in that being: the each component that comprises following weight portion in this chlorine dioxide mucosa gel:
Contain ClO
2Concentration is that immediate release property aqueous solution of chlorine dioxide 2 ~ 5 weight portions, carbomer 934 P 0.8 ~ 3 weight portion, hydroxypropyl emthylcellulose 0.5 ~ 1 weight portion, pharmaceutical grade glycerol 10 ~ 15 weight portions, the concentration expressed in percentage by weight of 2000PPM is 15% sodium hydrate aqueous solution 0.1 ~ 0.5 weight portion, disodiumedetate 0.05 ~ 0.2 weight portion, purified water 70 ~ 90 weight portions;
Earlier disodiumedetate is dissolved in the purified water, makes disodium ethylene diamine tetra-acetic acid aqueous solution;
Half of getting the disodium ethylene diamine tetra-acetic acid aqueous solution total amount heats up, and hydroxypropyl emthylcellulose stirs and is dispersed in the disodium ethylene diamine tetra-acetic acid aqueous solution after the intensification, obtains mixed solution; Mixed solution obtains clear and bright mixed solution after being cooled to room temperature; Get the disodium ethylene diamine tetra-acetic acid aqueous solution that total amount remains half and mix with pharmaceutical grade glycerol, carbomer 934 P, fully after the dissolving, the dropping sodium aqueous solution also stirs, and makes the gel base material; Again with clear and bright mixed solution, gel base material and contain ClO
2Concentration is the mixing of immediate release property aqueous solution of chlorine dioxide, stirring, the vacuum defoamation of 2000PPM, makes chlorine dioxide mucosa gel.
2. the preparation method of the described chlorine dioxide mucosa of claim 1 gel is characterized in that this preparation method comprises the steps:
A, the disodiumedetate of 0.05 ~ 0.2 weight portion is dissolved in the purified water of 70 ~ 90 weight portions, makes disodium ethylene diamine tetra-acetic acid aqueous solution, standby;
B, get disodium ethylene diamine tetra-acetic acid aqueous solution total amount that step a obtains half be warming up to 83 ~ 87 ℃, the hydroxypropyl emthylcellulose of 0.5 ~ 1 weight portion is stirred and is dispersed in the disodium ethylene diamine tetra-acetic acid aqueous solution after the intensification, obtain mixed solution;
C, the mixed solution that step b is obtained are cooled to room temperature and were placed in 3 ~ 5 ℃ the environment 10 ~ 14 hours, obtain clear and bright mixed solution;
D, get step a total amount and remain the disodium ethylene diamine tetra-acetic acid aqueous solution of half and mix with the pharmaceutical grade glycerol of 10 ~ 15 weight portions, the carbomer 934 P of 0.8 ~ 3 weight portion, fully after the dissolving, the dropping concentration expressed in percentage by weight is 15% sodium hydrate aqueous solution totally 0.1 ~ 0.5 weight portion and stirring, makes the gel base material;
E, the clear and bright mixed solution that step c is obtained, gel base material that steps d obtains, contain ClO
2Concentration is 2 ~ 5 weight portion mixing of immediate release property aqueous solution of chlorine dioxide, stirring, the vacuum defoamation of 2000PPM, makes chlorine dioxide mucosa gel; Described vacuum be-0.06 MPa～-0.08MPa.
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| CN2010105253605A CN101972271B (en) | 2010-10-31 | 2010-10-31 | Chlorine dioxide mucous membrane gel and preparation method thereof |
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| CN2010105253605A CN101972271B (en) | 2010-10-31 | 2010-10-31 | Chlorine dioxide mucous membrane gel and preparation method thereof |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111264556A (en) * | 2020-03-10 | 2020-06-12 | 宋健 | Gel for chlorine dioxide air disinfection and preparation method thereof |
| CN112970775A (en) * | 2021-01-26 | 2021-06-18 | 孙秀会 | Formula, preparation process and preparation device of low-temperature hypochlorous acid disinfectant |
| CN113396901A (en) * | 2021-06-25 | 2021-09-17 | 新乡市康大消毒剂有限公司 | Gel for slowly releasing chlorine dioxide and preparation method thereof |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1222345A (en) * | 1997-12-01 | 1999-07-14 | 段建涛 | Gargle containing chlorine dioxide |
| CN101669518A (en) * | 2009-09-30 | 2010-03-17 | 北京欧凯纳斯科技有限公司 | Germicidal antiviral composite containing chlorine dioxide |
-
2010
- 2010-10-31 CN CN2010105253605A patent/CN101972271B/en active Active
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1222345A (en) * | 1997-12-01 | 1999-07-14 | 段建涛 | Gargle containing chlorine dioxide |
| CN101669518A (en) * | 2009-09-30 | 2010-03-17 | 北京欧凯纳斯科技有限公司 | Germicidal antiviral composite containing chlorine dioxide |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111264556A (en) * | 2020-03-10 | 2020-06-12 | 宋健 | Gel for chlorine dioxide air disinfection and preparation method thereof |
| CN112970775A (en) * | 2021-01-26 | 2021-06-18 | 孙秀会 | Formula, preparation process and preparation device of low-temperature hypochlorous acid disinfectant |
| CN113396901A (en) * | 2021-06-25 | 2021-09-17 | 新乡市康大消毒剂有限公司 | Gel for slowly releasing chlorine dioxide and preparation method thereof |
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| CN101972271B (en) | 2012-07-04 |
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Effective date of registration: 20200330 Address after: 2140002 Room 101, No. 346, Caozhang new village, Liangxi District, Wuxi City, Jiangsu Province Patentee after: Song Jian Address before: 214151, No. 9, Zhang Sheng Road, West Zhang Industrial Park, Qian Qiao Town, Huishan District, Jiangsu, Wuxi Patentee before: WUXI LOVE TAG ART MATERIALS Co.,Ltd. |