CN101711725B - Mosquito-repellent perfume and preparation method thereof - Google Patents
Mosquito-repellent perfume and preparation method thereof Download PDFInfo
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- CN101711725B CN101711725B CN2009101127742A CN200910112774A CN101711725B CN 101711725 B CN101711725 B CN 101711725B CN 2009101127742 A CN2009101127742 A CN 2009101127742A CN 200910112774 A CN200910112774 A CN 200910112774A CN 101711725 B CN101711725 B CN 101711725B
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Abstract
The invention discloses a mosquito-repellent perfume and a preparation method thereof, and relates to a perfume. The invention provides a mosquito-repellent perfume having little dosage and long effective mosquito-repellent time, and a preparation method thereof. The mosquito-repellent perfume comprises the following raw materials in percentage by mass: 3 to 5 percent of deet, 3 to 5 percent of emulsifier, 0.2 to 0.5 percent of beta-cyclodextrine, 0.05 to 0.1 percent of methylparaben, 0.2 to 0.5 percent of perfume, 3 to 6 percent of glycerin, 0.7 to 1 percent of sodium chloride, 15 to 20 percent of ethanol and the balance of water. The preparation method comprises the following steps of: adding the water, the ethanol, the deet, the emulsifier and the beta-cyclodextrine into a reaction kettle, and stirring to obtain a mixture A; adding the glycerin and the perfume into the mixture A, and stirring to obtain a mixture B; and adding the methylparaben and the sodium chloride into the mixture B, stirring, standing and defoaming to obtain the mosquito-repellent perfume. The obtained mosquito-repellent perfume is transparent liquid.
Description
Technical field
The present invention relates to a kind of floral water, especially relate to a kind of floral water and preparation method thereof with mosquito-repelling function.
Background technology
Mosquito-driving liquid is protected in existing commercially available Europe, contains diethyltoluamide (DEET) 7.5%, and effectively the anophelifuge time has only 4h.And mosquito-repellent liquid is protected in another kind of product Europe, contains diethyltoluamide 7.5%, and effectively the anophelifuge time has only 5h.
(the Chinese name of an article: matto) diethyltoluamide content is up to 25%, and its illustrated anophelifuge timeliness also only reaches 8h with the brand product DEEP WOOS of the former medicine of U.S.'s import preparation.
Notification number comprises: dimethyl phthalate 2.0%～8% for the patent of invention of CN1548028 provides a kind of mosquito-repellent perfume; Plants essential oil 0.1%～5%.Wherein, plants essential oil is selected from two or more in the following material: oil of rosemary, eucalyptus oil, pinke needle oil, Oleum menthae, Oleum lavandula angustifolia, Flos Matricariae chamomillae, Oleum Caryophylli, thyme oil, Oleum Pelargonii Graveolentis, Oleum Rosae Rugosae, citronella oil, oleum juniperi e baccarae.Mosquito-repellent perfume second alcohol and water (70%～85%: preparation 30%～15%), also contain " Pleasures " perfume flavor essence 0.5%～3%.The mosquito-repellent perfume of this invention has that the miliaria of dispelling is antipruritic, refreshment and effectively protect skin to avoid the effect of sting, and anophelifuge is for up to 5～7h.The product of this invention does not cause allergic reaction to skin, mucosa avirulence, and has stable advantages of higher.
Publication number is that the application for a patent for invention of CN101347395 discloses a kind of Chinese medicine floral water of preventing and treating mosquito bite, comprises glycyrrhizic acid dipotassium 0.001%～0.5%, baicalin 0.001%～0.5%, Chinese medicine extract 0.01%～5%.Wherein, Chinese medicine extract is selected from following two kinds or two or more: Flos Campsis extract, Herba portulacae extract, Herba Violae extract, Flos Chrysanthemi Indici extract, Radix Sophorae Flavescentis extract, Cortex Dictamni extract.This Chinese medicine floral water can be prepared with the second alcohol and water, and the ratio of ethanol and water is about 60%～85%: 40%～15%, wherein also contain green tea essence, and consumption is 0.5%～3%.This Chinese medicine floral water can be made into external spraying agent or aerosol, directly is sprayed on the skin in use, and the effect of have anti-bacterial, anti-itching, reducing swelling and alleviating pain, the mosquito-proof miliaria of dispelling, relieving summer heat and refreshing oneself can be used for adult and child's skin daily nursing.
Summary of the invention
The object of the present invention is to provide a kind of diethyltoluamide consumption less, mosquito-repellent perfume that the anophelifuge timeliness is long and preparation method thereof.
The raw material of mosquito-repellent perfume of the present invention form and by mass percentage content be:
Diethyltoluamide (DEET) 3%～5%;
Emulsifying agent 3%～5%;
(β-CD) 0.2%～0.5% for cycloheptaamylose;
Methyl parahydroxybenzoate (MP) 0.05%～0.1%;
Spice 0.2%～0.5%;
Glycerol 3%～6%;
Sodium chloride (NaCl) 0.7%～1%;
Ethanol 15%～20%;
Yu Weishui.
Described emulsifying agent can adopt triton x-100 etc.
Described spice can be selected from least a in green tea oil, vanillin, jasmine flower essence, sandalwood fragrance, the orchid compound etc.
The preparation method of mosquito-repellent perfume of the present invention may further comprise the steps:
1) water, ethanol, diethyltoluamide, emulsifying agent and cycloheptaamylose are added reactor, stir, get mixture A;
2) in mixture A, add glycerol and spice, stir, must mix B;
3) add methyl parahydroxybenzoate and sodium chloride in mixture B, stir, leave standstill, froth breaking gets mosquito-repellent perfume, and the anophelifuge liquid distilled from honeysuckle flowers or lotus leaves of gained is the liquid of clear.
In step 1), the time of described stirring is preferably 10～15min.
In step 2) in, the time of described stirring is preferably 5～10min.
The using method of described mosquito-repellent perfume is as follows:
Human body such as adversary, foot exposure portion can be sprayed on human body exposure portion such as hands, foot with the form of spraying with product, and the reuse palm is smeared and evenly got final product; To exposure portion such as face, necks, can earlier product be sprayed on palm, exposure portion such as face, neck are smeared evenly get final product then.
Compare with products such as existing mosquito-repellent perfumes, the present invention has following outstanding advantage:
1. because the present invention adopts emulsifying-inclusion technique, promptly adopt cycloheptaamylose enclose anophelifuge effective ingredient diethyltoluamide (DEET), therefore not only increased the water solublity of diethyltoluamide, make it to be easy to emulsifying, thereby make stable formulation, and more relevant be since β-CD to effective clathration of DEET, make DEET not volatile, lost, therefore within a certain period of time, DEET can keep enough concentration, DEET is slowly discharged, thereby make DEET in 6h, can both keep enough concentration, guarantee that effective anophelifuge timeliness is longer.This just greatly reduces the use amount that nervous system is had certain toxic DEET.Because mosquito has produced Drug resistance to DEET, though the content of many product DEET indicates that at below 8% of national regulation for pursuing the anophelifuge timeliness, actual DEET consumption exceeds standard greatly, what have exceeds standard 2～5 times.And the DEET consumption only is about 60% of a national regulation consumption among the present invention, and the anophelifuge timeliness reaches more than the 6h, meets the A grade standard of national regulation, is a kind of safer long-acting mosquito-driving new formulation.
2. with the comparison of domestic and international product:
Mosquito-driving liquid is protected in existing commercially available Europe, contains diethyltoluamide (DEET) 7.5%, and effectively the anophelifuge time has only 4h.And mosquito-repellent liquid is protected in another kind of product Europe, contains diethyltoluamide 7.5%, and effectively the anophelifuge time has only 5h.
(the Chinese name of an article: matto) diethyltoluamide content is up to 25%, and its illustrated anophelifuge timeliness also only reaches 8h with the brand product DEEP WOOS of the former medicine of U.S.'s import preparation.
Laboratory and field test through American-European authoritative institution, the relation of anophelifuge amine (DEET) content and anophelifuge timeliness sees Table 1.
Table 1
But the mosquito-repellent perfume that the present invention is prepared, its DEET content only is 5%, existing commercially available prod has only when DEET content during for 3 times of the DEET content of the prepared mosquito-repellent perfume of the present invention, and promptly 15%, its anophelifuge time is just suitable with the prepared mosquito-repellent perfume of the present invention.This shows that the DEET consumption of existing commercially available prod is big, but the anophelifuge timeliness is not long.
The specific embodiment
Following examples will the present invention is further illustrated.
Embodiment 1
Water, ethanol, diethyltoluamide, TritonX x-100 and cycloheptaamylose are added reactor, stir 10～15min, add glycerol and green tea oil again, restir 5～10min, add methyl parahydroxybenzoate and sodium chloride at last, leave standstill after continuing to stir, froth breaking gets mosquito-repellent perfume, and the anophelifuge liquid distilled from honeysuckle flowers or lotus leaves of gained is the liquid of clear.
Each raw material content by mass percentage is a diethyltoluamide 3%, TritonX x-1003%, cycloheptaamylose 0.3%, methyl parahydroxybenzoate 0.07%, green tea oil 0.5%, glycerol 5%, sodium chloride 0.8%, ethanol 15%, water 72.33%.
Embodiment 2
Preparation method is similar to Example 1, its difference be each raw material by mass percentage content be diethyltoluamide 3.5%, TritonX x-1004.5%, cycloheptaamylose 0.35%, methyl parahydroxybenzoate (MP) 0.08%, vanillin 0.3%, glycerol 3%, sodium chloride 0.75%, ethanol 17%, water 70.52%.
Embodiment 3
Preparation method is similar to Example 1, its difference be each raw material by mass percentage content be diethyltoluamide 4%, TritonX x-1004%, cycloheptaamylose 0.4%, methyl parahydroxybenzoate (MP) 0.05%, jasmine flower essence 0.4%, glycerol 4%, sodium chloride 0.7%, ethanol 19%, water 67.45%.
Embodiment 4
Preparation method is similar to Example 1, its difference be each raw material by mass percentage content be diethyltoluamide 4.5%, TritonX x-1004.5%, cycloheptaamylose 0.45%, methyl parahydroxybenzoate (MP) 0.1%, sandalwood fragrance 0.2%, glycerol 6%, sodium chloride 1%, ethanol 20%, water 63.25%.
Embodiment 5
Preparation method is similar to Example 1, its difference be each raw material by mass percentage content be diethyltoluamide 5%, TritonX-1005%, cycloheptaamylose 0.5%, methyl parahydroxybenzoate (MP) 0.09%, orchid compound 0.35%, glycerol 4.5%, sodium chloride 0.85%, ethanol 20%, water 63.71%.
Below provide result of the test:
1. experimental condition: warm and humid 26 ± 1 ℃ of laboratory, RH 65 ± 5%; The mosquito kind is an Aedes albopictus, emergence back 4～5 days; The mosquito number is 300 female insect/cages of not sucking blood (35cm * 35cm * 35cm); Jejunitas before the examination is 18h.
2. dosage: 1.5 μ l/cm
2
3. result of the test: the prepared mosquito-repellent perfume of the present invention is respectively 8h, 7.8h and 8h to the effective protecting time of Aedes albopictus, and the average effective guard time is 7.83 ± 0.29h, and absolutely guard time is 7.5h.
4. evaluation of result: estimate by 2.2 pharmacodynamics indexs among standard GB/T17322.10-1998 " indoor harmacological effect of agriculture chemical registration hygienic insecticide is estimated repellant "; 5% diethyltoluamide mosquito-repellent perfume is 7.83 ± 0.29h to the average effective guard time of Aedes albopictus; absolutely guard time is 7.5h; 〉=6h, drug effect belongs to the A level.
Claims (5)
1. mosquito-repellent perfume, it is characterized in that its raw material is formed and by mass percentage content be:
Diethyltoluamide 3%～5%;
Emulsifying agent triton x-100 3%～5%;
Cycloheptaamylose 0.2%～0.5%;
Methyl parahydroxybenzoate 0.05%～0.1%;
Spice 0.2%～0.5%;
Glycerol 3%～6%;
Sodium chloride 0.7%～1%;
Ethanol 15%～20%;
Yu Weishui.
2. a kind of mosquito-repellent perfume as claimed in claim 1 is characterized in that described spice is selected from least a in green tea oil, vanillin, jasmine flower essence, sandalwood fragrance, the orchid compound.
3. the preparation method of a kind of mosquito-repellent perfume as claimed in claim 1 is characterized in that may further comprise the steps:
1) water, ethanol, diethyltoluamide, emulsifying agent triton x-100 and cycloheptaamylose are added reactor, stir, get mixture A;
2) in mixture A, add glycerol and spice, stir, must mix B;
3) add methyl parahydroxybenzoate and sodium chloride in mixture B, stir, leave standstill, froth breaking gets mosquito-repellent perfume, and the mosquito-repellent perfume of gained is the liquid of clear.
4. the preparation method of a kind of mosquito-repellent perfume as claimed in claim 3 is characterized in that in step 1), and the time of described stirring is 10～15min.
5. the preparation method of a kind of mosquito-repellent perfume as claimed in claim 3 is characterized in that in step 2) in, the time of described stirring is 5～10min.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
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| CN2009101127742A CN101711725B (en) | 2009-11-09 | 2009-11-09 | Mosquito-repellent perfume and preparation method thereof |
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| Application Number | Priority Date | Filing Date | Title |
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| CN2009101127742A CN101711725B (en) | 2009-11-09 | 2009-11-09 | Mosquito-repellent perfume and preparation method thereof |
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| CN101711725A CN101711725A (en) | 2010-05-26 |
| CN101711725B true CN101711725B (en) | 2011-06-29 |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2023006190A1 (en) * | 2021-07-28 | 2023-02-02 | Wacker Chemie Ag | Cyclodextrin-containing formulations for volatile substances with additives in order to maintain constant release |
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| CN103830131A (en) * | 2012-11-27 | 2014-06-04 | 顾月燕 | Preparation method of floral water for children |
| CN102988233A (en) * | 2012-11-27 | 2013-03-27 | 顾月燕 | Floral water for children |
| CN103591836A (en) * | 2013-11-18 | 2014-02-19 | 山西大学 | Multifunctional children water gun fluid |
| CN104288033A (en) * | 2014-09-30 | 2015-01-21 | 江苏奇力康皮肤药业有限公司 | Mosquito-repellent floral water and preparation method thereof |
| CN105878052A (en) * | 2016-05-16 | 2016-08-24 | 薛采芳 | Anti-mosquito repellent suitable for high-temperature and high-humidity environment and preparation method of anti-mosquito repellent |
| CN105997661A (en) * | 2016-06-22 | 2016-10-12 | 江苏奇力康皮肤药业有限公司 | Mosquito-repellent spray used on skin surface |
| CN106342955A (en) * | 2016-08-30 | 2017-01-25 | 四川达文西科技有限公司 | Health-care and tranquilizing repellent liquid |
| CN113318047A (en) * | 2021-06-10 | 2021-08-31 | 山东省润荷卫生材料有限公司 | Mosquito-repellent wet tissue and production method thereof |
| CN114832670A (en) * | 2022-05-26 | 2022-08-02 | 福建省欧赛加日用品有限公司 | Mosquito-repellent floral water and preparation process and preparation system thereof |
| FR3147948A1 (en) * | 2023-04-20 | 2024-10-25 | Laboratoire Astelia | Soothing after injection, high tolerance without any contraindications |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101187158A (en) * | 2007-12-07 | 2008-05-28 | 深圳清华大学研究院 | Mosquito-proof finishing agent and preparation method and its uses in mosquito-preventing fabric |
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Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101187158A (en) * | 2007-12-07 | 2008-05-28 | 深圳清华大学研究院 | Mosquito-proof finishing agent and preparation method and its uses in mosquito-preventing fabric |
Non-Patent Citations (1)
| Title |
|---|
| 张稷博、关玉辉等.避蚊胺包结化合物的研制及其生物效能评价.《中国媒介生物学及控制杂志》.2001,第12卷(第1期),56-57. * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2023006190A1 (en) * | 2021-07-28 | 2023-02-02 | Wacker Chemie Ag | Cyclodextrin-containing formulations for volatile substances with additives in order to maintain constant release |
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| CN101711725A (en) | 2010-05-26 |
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