CN110179693B - Mosquito-repelling itching-relieving compound essential oil, preparation method and application thereof, and mosquito-repelling itching-relieving article - Google Patents

Mosquito-repelling itching-relieving compound essential oil, preparation method and application thereof, and mosquito-repelling itching-relieving article Download PDF

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CN110179693B
CN110179693B CN201910519943.8A CN201910519943A CN110179693B CN 110179693 B CN110179693 B CN 110179693B CN 201910519943 A CN201910519943 A CN 201910519943A CN 110179693 B CN110179693 B CN 110179693B
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essential oil
mosquito
itching
repelling
relieving
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CN110179693A (en
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伍振峰
杨明
康超超
郑琴
王雅琪
万娜
岳鹏飞
朱根华
胡鹏翼
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Jiangxi University of Traditional Chinese Medicine
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Abstract

The invention provides mosquito-repelling and itching-relieving compound essential oil, a preparation method and application thereof, and a mosquito-repelling and itching-relieving article, and relates to the technical field of essential oil, wherein the mosquito-repelling and itching-relieving compound essential oil comprises the following components in parts by weight: 0.5-2 parts of citronella essential oil, 0.3-1.5 parts of eucalyptus citriodora leaf oil, 0.1-1 part of rosemary essential oil, 0.1-1 part of basil essential oil, 0.08-0.8 part of silvery chrysanthemum essential oil, 0.5-1.5 parts of elsholtzia essential oil, 0.1-1 part of amomum cardamomum essential oil and 0.08-0.8 part of geranium essential oil, improves the technical problems that the traditional mosquito repellent product has larger toxicity, pollutes the environment and affects the body health, the mosquito repellent and itching relieving product has certain irritation and toxicity, the single mosquito repellent essential oil has single effect, and the mosquito repellent efficiency is not high. The mosquito-repelling and itching-relieving compound essential oil provided by the invention has the advantages of being green, healthy, pollution-free, low in toxicity, free of irritation, obvious in mosquito-repelling and itching-relieving effect and the like, and is simple to prepare, convenient to use and good in application prospect.

Description

Mosquito-repelling itching-relieving compound essential oil, preparation method and application thereof, and mosquito-repelling itching-relieving article
Technical Field
The invention relates to the technical field of essential oil, in particular to mosquito-repelling itching-relieving compound essential oil, a preparation method and application thereof, and a mosquito-repelling itching-relieving article.
Background
Mosquitoes often carry pathogenic bacteria such as staphylococcus aureus, bacillus subtilis, escherichia coli, pseudomonas aeruginosa and the like, skin is stabbed, red and swollen and itchy after being bitten by the mosquitoes, skin is easily chapped and infected after being repeatedly scratched, a long-term scar is caused due to improper treatment, diseases are easily spread, and the mosquitoes bite the skin to seriously disturb the sleep of people, so that the learning, the work and the life are seriously influenced.
At present, mosquito repellent products in the market are full of Linglan, such as traditional mosquito-repellent incense, electric heating mosquito-repellent incense sheets and electric heating mosquito-repellent incense liquid, which contain pyrethroid chemical insecticides and generate smoke when in use, the toxicity of the chemical mosquito-repellent incense is high, the chemical mosquito-repellent incense not only harms human health and reduces human immunity, but also causes harmful effects on respiratory systems and brings discomfort to people after being frequently used for a long time; the mosquito-repellent antipruritic products in the market are also many, such as floral water, mosquito-repellent antipruritic cream and the like, most mosquito-repellent floral water contains a chemosynthetic repellent, namely DEET or anophelifuge, and the chemosynthetic repellent has certain irritation and toxicity. However, with the continuous improvement of modern living standard, the safety consciousness of people is continuously improved, various mosquito repellent products at present can not meet the requirements of consumers, people are more and more pursuing safe, natural, non-toxic and efficient mosquito repellent and itching relieving products, most of the mosquito repellent essential oils on the market at present are prepared by mixing single essential oil and base oil, the effect is single, the mosquito repellent efficiency is not high, and the mosquito repellent is difficult to popularize and use.
In view of the above, the present invention is particularly proposed.
Disclosure of Invention
The invention aims to provide the mosquito-repelling and itching-relieving compound essential oil, which solves the technical problems that the traditional mosquito-repelling product chemical mosquito-repelling agent has high toxicity, pollutes the environment and influences the health of the body, the chemosynthetic repellent of the mosquito-repelling and itching-relieving product has certain irritation and toxicity, the single-component mosquito-repelling essential oil has single effect, and the mosquito-repelling efficiency is low.
The mosquito-repelling itching-relieving compound essential oil provided by the invention comprises the following components in parts by weight: 0.5-2 parts of citronella essential oil, 0.3-1.5 parts of eucalyptus citriodora leaf oil, 0.1-1 part of rosemary essential oil, 0.1-1 part of basil essential oil, 0.08-0.8 part of silver chrysanthemum essential oil, 0.5-1.5 parts of elsholtzia essential oil, 0.1-1 part of amomum cardamomum essential oil and 0.08-0.8 part of geranium essential oil.
Further, the mosquito-repelling itching-relieving compound essential oil comprises the following components in parts by weight: 0.75-1.8 parts of citronella essential oil, 0.4-1 part of eucalyptus citriodora leaf oil, 0.2-0.8 part of rosemary essential oil, 0.2-0.8 part of basil essential oil, 0.1-0.5 part of silver chrysanthemum essential oil, 0.5-1.2 parts of elsholtzia essential oil, 0.35-0.9 part of amomum cardamomum essential oil and 0.2-0.3 part of geranium essential oil.
Further, the mosquito-repelling itching-relieving compound essential oil comprises the following components in parts by weight: 1.25 parts of citronella essential oil, 0.75 part of eucalyptus citriodora leaf oil, 0.5 part of rosemary essential oil, 0.5 part of basil essential oil, 0.25 part of silver chrysanthemum essential oil, 1 part of elsholtzia essential oil, 0.5 part of amomum cardamomum essential oil and 0.25 part of geranium essential oil.
Further, the oil also comprises base oil;
preferably, the base oil is 0.1 to 95 parts by mass, preferably 75 to 95 parts;
preferably, the base oil is selected from at least one of sweet almond oil, grape seed oil, jojoba oil or wheat germ oil, preferably grape seed oil.
The second purpose of the invention is to provide a preparation method of the mosquito-repellent itching-relieving compound essential oil, which comprises the following steps:
the mosquito-repelling and itching-relieving compound essential oil is prepared by respectively crushing and sieving citronella, eucalyptus citriodora leaves, rosemary, basil, silverweed chrysanthemum, elsholtzia, amomum cardamomum and geranium to obtain crude medicinal powder, then respectively soaking and distilling to obtain essential oil, and finally uniformly mixing citronella essential oil, eucalyptus citriodora leaves essential oil, rosemary essential oil, basil essential oil, silverweed essential oil, elsholtzia essential oil, cardamom essential oil, geranium essential oil and optional base oil.
Further, in the screening step, the selected screen is a No. 5 screen;
preferably, in the distillation step, the essential oil is prepared by adopting a steam distillation method, and the distillation time is 6-10h, preferably 8 h.
Further, in the soaking step, distilled water is adopted to soak the crude medicinal powder, and the mass ratio of the crude medicinal powder to the distilled water is 1:8-12, preferably 1: 10.
The third purpose of the invention is to provide the application of the mosquito-repellent itching-relieving compound essential oil in preparing mosquito-repellent itching-relieving articles.
The fourth purpose of the invention is to provide a mosquito-repelling and itching-relieving article, which comprises the mosquito-repelling and itching-relieving compound essential oil provided by the invention.
Further, the mosquito-repellent itching-relieving product comprises a sachet, a slow-release hanging tablet, a spray, an aerosol, a cream and a nano-emulsion.
Compared with the prior art, the invention has the following beneficial effects:
under the guidance of the combination of the compatibility theory of traditional Chinese medicines and the essential oil blending technology, the mosquito-repellent, bactericidal and refreshing citronella essential oil, the mosquito-repellent, bactericidal, dampness-eliminating and detoxifying eucalyptus citriodora leaf oil, the refreshing rosemary essential oil, the mosquito-repellent, antibacterial and antioxidant basil essential oil and the cool and fragrant senecio flower essential oil are taken as repellent agents and are blended with the pain-relieving, inflammation-diminishing and bactericidal elsholtzia essential oil, the dampness-resolving, qi-moving and tranquilizing amomum cardamomum essential oil and the pain-relieving, antibacterial and skin cell regeneration-promoting geranium essential oil which are taken as antipruritic agents, and the mosquito-repellent and itching-relieving compound essential oil is prepared by supplementing the raw material components, realizing synergistic effect and supplementing optional base oil. The mosquito-repelling and itching-relieving compound essential oil provided by the invention has the advantages of being green and healthy, free of pollution, low in toxicity, free of irritation, obvious in mosquito-repelling and itching-relieving effect and the like, has no adverse reactions such as redness and swelling, itching and burning sensation to skin, has the effects of clearing damp and refreshing mind, can relieve summer discomfort and has a good application prospect.
The preparation method of the mosquito-repelling itching-relieving compound essential oil provided by the invention is simple, is convenient to operate, and can be produced in a large scale.
The mosquito-repellent itching-relieving article provided by the invention has the advantages of being green, healthy, pollution-free, low in toxicity, free of irritation, obvious in mosquito-repellent itching-relieving effect and the like, and has a wide application prospect.
Detailed Description
Embodiments of the present invention will be described in detail below with reference to examples, but it will be understood by those skilled in the art that the following examples are only illustrative of the present invention and should not be construed as limiting the scope of the present invention. The examples, in which specific conditions are not specified, were conducted under conventional conditions or conditions recommended by the manufacturer.
According to one aspect of the invention, the invention provides mosquito-repelling itching-relieving compound essential oil which comprises the following components in parts by weight: 0.5-2 parts of citronella essential oil, 0.3-1.5 parts of eucalyptus citriodora leaf oil, 0.1-1 part of rosemary essential oil, 0.1-1 part of basil essential oil, 0.08-0.8 part of silver chrysanthemum essential oil, 0.5-1.5 parts of elsholtzia essential oil, 0.1-1 part of amomum cardamomum essential oil and 0.08-0.8 part of geranium essential oil.
Under the guidance of the combination of the compatibility theory of traditional Chinese medicines and the blending technology of essential oil, the mosquito-repellent, bactericidal and refreshing citronella essential oil, the mosquito-repellent, bactericidal, dampness-eliminating and detoxifying eucalyptus citriodora leaf oil, the refreshing rosemary essential oil, the mosquito-repellent, antibacterial and antioxidant basil essential oil and the cool and fragrant chrysanthemum essential oil are taken as repellent agents, and are blended with the analgesic, anti-inflammatory and bactericidal elsholtzia essential oil, the damp-resolving, qi-moving and tranquilizing amomum cardamomum essential oil and the analgesic, antibacterial and skin cell regeneration promoting geranium essential oil which are taken as antipruritic agents, so that the mosquito-repellent and antipruritic compound essential oil is prepared by supplementing each other, realizing synergistic effect and supplementing sweet almond oil or jojoba oil or grape seed oil or wheat germ oil as base oil. The mosquito-repelling and itching-relieving compound essential oil provided by the invention has the advantages of being green and healthy, free of pollution, low in toxicity, free of irritation, obvious in mosquito-repelling and itching-relieving effect and the like, has no adverse reactions such as redness and swelling, itching and burning feeling to skin, has the effects of clearing damp and refreshing mind, can relieve summer discomfort, and is good in application prospect.
Typical but not limiting parts by mass of citronella essential oil in the present invention are, for example, 0.5, 0.55, 0.6, 0.65, 0.7, 0.75, 08, 0.85, 0.9, 0.95, 1, 1.05, 1.1, 1.15, 1.2, 1.25, 1.3, 1.35, 1.4, 1.45, 1.5, 1.55, 1.6, 1.65, 1.7, 1.75, 1.8, 1.85, 1.9, 1.95 or 2 parts. The citronella essential oil has the functions of repelling mosquitoes, sterilizing, refreshing brain and purifying air.
Typical but non-limiting parts by mass of eucalyptus citriodora leaf oil are for example 0.3, 0.35, 0.4, 0.45, 0.5, 0.55, 0.6, 0.65, 0.7, 0.75, 08, 0.85, 0.9, 0.95, 1, 1.05, 1.1, 1.15, 1.2, 1.25, 1.3, 1.35, 1.4, 1.45 or 1.5 parts. The Eucalyptus citriodora leaf oil has the effects of repelling mosquitoes, sterilizing, dispelling wind, relieving fever, eliminating dampness and detoxifying.
Typical but not limiting mass parts of rosemary essential oil are e.g. 0.1, 0.15, 0.2, 0.25, 0.3, 0.35, 0.4, 0.45, 0.5, 0.55, 0.6, 0.65, 0.7, 0.75, 08, 0.85, 0.9, 0.95 or 1 part. The rosemary essential oil contains mosquito repellent active ingredients such as limonene and camphor, has cool and refreshing smell of green grass and sweet camphor smell, and can refresh and refresh the brain and enhance the memory.
Typical but not limiting mass parts of basil essential oil are e.g. 0.1, 0.15, 0.2, 0.25, 0.3, 0.35, 0.4, 0.45, 0.5, 0.55, 0.6, 0.65, 0.7, 0.75, 08, 0.85, 0.9, 0.95 or 1 part. The basil essential oil contains mosquito repellent active ingredients such as linalool and cineole, and has the effects of repelling mosquito, inhibiting bacteria, resisting oxidation, dispelling wind, relieving exterior syndrome, eliminating dampness, neutralizing, relieving pain and relieving itching.
Typical but non-limiting parts by mass of the guayule essential oil are, for example, 0.08, 0.1, 0.15, 0.2, 0.25, 0.3, 0.35, 0.4, 0.45, 0.5, 0.55, 0.6, 0.65, 0.7, 0.75 or 0.8 parts. The essential oil of the silvery chrysanthemum contains anophelifuge active ingredients such as artemisone, beta-phellandrene and the like, can trap and kill mosquito larvae, and simultaneously has cool fragrance similar to citrus and pepper.
Typical but not limiting parts by mass of the elsholtzia essential oil are for example 0.5, 0.55, 0.6, 0.65, 0.7, 0.75, 08, 0.85, 0.9, 0.95, 1, 1.05, 1.1, 1.15, 1.2, 1.25, 1.3, 1.35, 1.4, 1.45 or 1.5 parts. The herba Moslae essential oil has effects of promoting diuresis, eliminating dampness, warming stomach, regulating middle warmer, enhancing immunity, relieving pain, diminishing inflammation and killing bacteria.
Typical but not limiting parts by mass of the cardamom essential oil are, for example, 0.1, 0.15, 0.2, 0.25, 0.3, 0.35, 0.4, 0.45, 0.5, 0.55, 0.6, 0.65, 0.7, 0.75, 0.8, 0.85, 0.9, 0.95 or 1 part. The cardamom essential oil has the functions of eliminating dampness, promoting the circulation of qi, tranquilizing, resisting oxidation and free radicals and promoting the self-repair of skin.
Typical but non-limiting parts by mass of the geranium essential oil are, for example, 0.08, 0.1, 0.15, 0.2, 0.25, 0.3, 0.35, 0.4, 0.45, 0.5, 0.55, 0.6, 0.65, 0.7, 0.75 or 0.8 parts. The geranium essential oil has the effects of relieving pain, resisting bacteria, enhancing cell defense function, promoting skin cell regeneration and repairing scar.
In a preferred embodiment of the invention, the mosquito-repellent itching-relieving compound essential oil also comprises 0.1-95 parts by mass of base oil;
preferably, the base oil is present in an amount of 75 to 95 parts by mass, more preferably 95 parts.
Typical but non-limiting mass parts of base oil in the present invention are, for example, 0, 2, 4, 6, 8, 10, 12, 14, 16, 18, 20, 22, 24, 26, 28, 30, 32, 34, 36, 38, 40, 42, 44, 46, 48, 50, 52, 54, 56, 58, 60, 62, 64, 66, 68, 70, 72, 74, 76, 78, 80, 82, 84, 86, 88, 90, 92, 94 or 95 parts.
In a preferred embodiment of the present invention, the base oil is selected from at least one of sweet almond oil, grape seed oil, jojoba oil or wheat germ oil.
Sweet almond oil is a neutral base oil, has the functions of lubrication, refreshment and skin friendliness, and is mainly used as a formula for treating skin pruritus, dryness and inflammation.
The grape seed oil has strong permeability, antioxidant and astringent effects, and can moisten and soften skin.
Jojoba oil has strong permeability, skin caring, moistening and moisture keeping effects.
The wheat germ oil has effects of regulating oil secretion, resisting oxidation, resisting skin aging and caring skin.
In a further preferred embodiment of the invention, the base oil is grape seed oil.
According to a second aspect of the invention, the invention provides a preparation method of mosquito-repellent itching-relieving compound essential oil, which comprises the following steps:
the mosquito-repellent itching-relieving compound essential oil is prepared by respectively crushing and sieving citronella, eucalyptus citriodora leaves, rosemary, basil, silverweed chrysanthemum, elsholtzia, amomum cardamomum and geranium to obtain crude medicinal powder, then respectively soaking and distilling to obtain essential oil, and finally uniformly mixing citronella essential oil, eucalyptus citriodora leaves essential oil, rosemary essential oil, basil essential oil, silverweed chrysanthemum essential oil, elsholtzia essential oil, cardamom essential oil, geranium essential oil and optional base oil.
The preparation method of the mosquito-repelling itching-relieving compound essential oil provided by the invention is simple, is convenient to operate, and can be produced in a large scale.
In a preferred embodiment of the present invention, in the step of sieving, the selected screen is a No. 5 sieve.
By selecting the selected screen, medicinal material coarse powder with uniform and appropriate particle size can be obtained, so that the preparation of various subsequent raw material essential oils is facilitated, and the aim of fully utilizing medicinal materials is fulfilled.
In a preferred embodiment of the present invention, in the distillation step, the essential oil is prepared by steam distillation, and the distillation time is 6-10 h.
Typical but not limiting times for distillation in the present invention are e.g. 6, 6.5, 7, 7.5, 8, 8.5, 9, 9.5 or 10 h.
By controlling the distillation time, the mosquito-repellent itching-relieving compound essential oil with better effect can be prepared. The distillation time is within 6-10h, and the mosquito-repelling and itching-relieving compound essential oil has good effect.
In a further preferred embodiment of the present invention, the distillation time is 8 h.
By further adjusting and optimizing the distillation time, the obtained mosquito-repelling itching-relieving compound essential oil has better effect.
In a preferred embodiment of the present invention, in the step of soaking, the crude drug powder is soaked in distilled water, and the mass ratio of the crude drug powder to the distilled water is 1: 8-12.
In the present invention, the typical but non-limiting mass ratio of the crude powder and the distilled water is 1:8, 1:9, 1:10, 1:11 or 1: 12.
By controlling the mass ratio of the medicinal coarse powder to the distilled water, the mosquito-repelling and itching-relieving compound essential oil with better effect can be prepared. The mass ratio of the crude powder of the medicinal materials to the distilled water is within the range of 1:8-12, and the mosquito-repelling and itching-relieving compound essential oil has good effect.
In a further preferred embodiment of the invention, the mass ratio of the crude drug powder to the distilled water is 1: 10.
The mosquito-repelling and itching-relieving compound essential oil has a better effect by further adjusting and optimizing the mass ratio of the medicinal coarse powder to the distilled water.
According to the third aspect of the invention, the invention provides the application of the mosquito-repellent itching-relieving compound essential oil in the preparation of mosquito-repellent itching-relieving articles.
According to a fourth aspect of the invention, the invention provides a mosquito-repelling and itching-relieving article, which comprises the mosquito-repelling and itching-relieving compound essential oil provided by the invention.
The mosquito-repellent itching-relieving article provided by the invention has the advantages of being green, healthy, pollution-free, low in toxicity, free of irritation, obvious in mosquito-repellent itching-relieving effect and the like, and has a wide application prospect.
In a preferred embodiment of the invention, the mosquito-repellent itching-relieving product comprises any one or more of sachets, slow-release hanging tablets, sprays, aerosols, creams and nano-emulsions.
For further understanding of the present invention, the effects of the present invention will be described in further detail with reference to specific examples and comparative examples. All the raw materials related to the invention can be obtained commercially.
Example 1
The embodiment provides mosquito-repelling itching-relieving compound essential oil which comprises the following components in parts by mass: 0.5 part of citronella essential oil, 1.5 parts of lemon eucalyptus oil, 0.1 part of rosemary essential oil, 1 part of basil essential oil, 0.08 part of silver chrysanthemum essential oil, 1.5 parts of elsholtzia essential oil, 0.1 part of amomum cardamomum essential oil, 0.8 part of geranium essential oil and 95 parts of grape seed oil.
Example 2
The embodiment provides mosquito-repelling itching-relieving compound essential oil which comprises the following components in parts by mass: 2 parts of citronella essential oil, 0.3 part of lemon eucalyptus oil, 1 part of rosemary essential oil, 0.1 part of basil essential oil, 0.8 part of silver fragrant chrysanthemum essential oil, 0.5 part of elsholtzia essential oil, 1 part of amomum cardamomum essential oil, 0.08 part of geranium essential oil and 95 parts of grape seed oil.
Example 3
The embodiment provides mosquito-repelling itching-relieving compound essential oil which comprises the following components in parts by mass: 0.75 part of citronella essential oil, 1 part of lemon eucalyptus oil, 0.2 part of rosemary essential oil, 0.8 part of basil essential oil, 0.1 part of silver chrysanthemum essential oil, 1.2 parts of elsholtzia essential oil, 0.35 part of amomum cardamomum essential oil, 0.3 part of geranium essential oil and 95 parts of grape seed oil.
Example 4
The embodiment provides mosquito-repelling itching-relieving compound essential oil which comprises the following components in parts by mass: 1.8 parts of citronella essential oil, 0.4 part of eucalyptus citriodora leaf oil, 0.8 part of rosemary essential oil, 0.2 part of basil essential oil, 0.5 part of silvery chrysanthemum essential oil, 0.5 part of elsholtzia essential oil, 0.9 part of amomum cardamomum essential oil, 0.2 part of geranium essential oil and 95 parts of grape seed oil.
Example 5
The embodiment provides mosquito-repelling itching-relieving compound essential oil which comprises the following components in parts by mass: 1.25 parts of citronella essential oil, 0.75 part of eucalyptus citriodora leaf oil, 0.5 part of rosemary essential oil, 0.5 part of basil essential oil, 0.25 part of silvery chrysanthemum essential oil, 1 part of elsholtzia essential oil, 0.5 part of amomum cardamomum essential oil, 0.25 part of geranium essential oil and 95 parts of grape seed oil.
Example 6
The embodiment provides a preparation method of mosquito-repelling itching-relieving compound essential oil, and the mosquito-repelling itching-relieving compound essential oil provided in the embodiments 1 to 5 is prepared according to the following steps:
(a) pulverizing herba Cymbopogonis Citrari, folium Eucalypti Citrari, herba Rosmarini officinalis, herba Ocimi, flos Inulae, herba Moslae, fructus Amomi rotundus, and flos Pelargonii Hortori respectively, and sieving with No. 5 sieve to obtain coarse powder;
(b) respectively adding the coarse powder of the medicinal materials obtained in the step (a) into the coarse powder of the medicinal materials according to a material-liquid ratio of 1:10 soaking in distilled water for 2 hr, distilling by steam distillation for 8 hr, and collecting condensed volatile oil with volatile oil extractor to obtain the above 8 kinds of essential oils;
(c) and (c) finally, putting the grape seed oil into a container, sequentially adding the essential oil prepared in the step (b) according to an optimal proportion from large to small, covering the container, and rolling forcibly to fully mix all the oil to obtain the mosquito-repelling and itching-relieving compound essential oil.
Comparative example 1
The present comparative example provides a mosquito-repelling itching-relieving compound essential oil, and the differences between this example and example 5 are that 0.2 part of citronella essential oil, 2 parts of eucalyptus citriodora leaf oil, 0.05 part of rosemary essential oil, 1.5 parts of basil essential oil, 0.04 part of silver chrysanthemum essential oil, 2 parts of elsholtzia essential oil, 0.05 part of amomum cardamomum essential oil, 1 part of geranium essential oil and 95 parts of grape seed oil.
Comparative example 2
The difference between the embodiment and the embodiment 5 lies in that 2.5 parts of citronella essential oil, 0.1 part of eucalyptus citriodora leaf oil, 1.5 parts of rosemary essential oil, 0.05 part of basil essential oil, 1 part of silver chamomile essential oil, 0.2 part of elsholtzia essential oil, 1.5 parts of amomum cardamomum essential oil, 0.04 part of geranium essential oil and 95 parts of grape seed oil.
Comparative example 3
The comparative example provides mosquito-repelling itching-relieving compound essential oil, and the difference between the example and the example 5 is that citronella essential oil is not added.
Comparative example 4
The comparative example provides mosquito-repelling and itching-relieving compound essential oil, and the difference between the example and the example 5 is that eucalyptus citriodora leaf oil is not added.
Comparative example 5
The comparative example provides mosquito-repelling itching-relieving compound essential oil, and the difference between the example and the example 5 is that rosemary essential oil is not added.
Comparative example 6
The comparative example provides mosquito-repelling itching-relieving compound essential oil, and the difference between the example and the example 5 is that basil essential oil is not added.
Comparative example 7
The comparative example provides mosquito-repelling and itching-relieving compound essential oil, and the difference between the example and the example 5 is that the silver chrysanthemum essential oil is not added.
Comparative example 8
The comparative example provides a mosquito-repelling and itching-relieving compound essential oil, and is different from the comparative example 5 in that elsholtzia essential oil is not added.
Comparative example 9
The comparative example provides a mosquito-repelling and itching-relieving compound essential oil, and is different from the comparative example 5 in that the cardamom essential oil is not added.
Comparative example 10
The comparative example provides mosquito-repelling itching-relieving compound essential oil, and is different from the comparative example 5 in that geranium essential oil is not added.
Comparative example 11
The comparative example provides mosquito-repelling and itching-relieving compound essential oil, and is different from the comparative example 5 in that citronella essential oil, lemon eucalyptus oil, rosemary essential oil, basil essential oil and silver chrysanthemum essential oil are not added.
Comparative example 12
The comparative example provides mosquito-repelling itching-relieving compound essential oil, and is different from the comparative example 5 in that elsholtzia essential oil, amomum cardamomum essential oil and geranium essential oil are not added.
Comparative example 13
The comparative example provides mosquito-repelling and itching-relieving toilet water, which is commercially available Liushen toilet water.
The preparation method of the mosquito-repelling and itching-relieving compound essential oil provided in the comparative examples 1 to 12 is the same as that of the mosquito-repelling and itching-relieving compound essential oil provided in the example 6, and the details are not repeated herein.
Experimental example 1 mosquito repelling experiment
1. Experimental animals: kunming mouse, 20g + -2 g, 50 mice, each half male and female. The test insect is culex pipiens blankii.
2. Test drugs: alcohol, the mosquito-repelling and itching-relieving compound essential oil provided in comparative examples 1-12, the Liushen flower water provided in comparative example 13 and the mosquito-repelling and itching-relieving compound essential oil provided in examples 1-5.
3. Grouping experiments: a negative control group (alcohol), a positive control group (Liushen toilet water provided in comparative example 13) and 1-17 groups (the mosquito-repelling and itching-relieving compound essential oil provided in examples 1-5 and the mosquito-repelling and itching-relieving compound essential oil provided in comparative examples 1-12).
4. The experimental method comprises the following steps: 190 mice (each half of male and female) are taken and divided into 19 groups, each group n is 10, four limbs of the mice are fixed on a wood board, villi with the diameter of 2cm of the abdomen is subtracted, then the mice are evenly coated on the exposed abdomen according to the medicine of 1.5uL/cm, the mice are placed into 50 x 50cm of culex fatting cages every 1h, 50 females are placed in each cage, the mice are parked for 3min, the presence or absence of mosquitoes and the blood sucking are observed, the mice are judged to be invalid as long as 1 mosquito sucks the blood, the average effective protection time is recorded, the standard deviation is calculated, and the effective protection rates of 4h, 5h, 6h and 7h are calculated. When the effective protection rate is more than 80%, the effective protection rate can be considered as effective, and when the effective protection rate is less than 80%, the effective protection rate is considered as no protection.
Effective protection rate (%) - (average number of bites in negative control group-average number of bites in test group)/average number of bites in negative control group [ < 100 [ ]
5. As a result: see table 1.
TABLE 1 effective protection time and effective protection rate of mosquito-repelling and itching-relieving compound essential oil
Figure BDA0002095381750000131
Note: p <0.01, P <0.05 compared to negative controls.
As can be seen from Table 1, the repelling time and the effective protection rate of the mosquito-repelling and itching-relieving compound essential oil provided by the groups 1-5 are obviously higher than those of the negative control group, which indicates that the mosquito-repelling effect of the mosquito-repelling and itching-relieving compound essential oil provided by the invention is very obvious. The comparison between the 1-5 groups and the positive control group shows that the repelling time and the effective protection rate of the mosquito-repelling and itching-relieving compound essential oil provided by the invention are both superior to those of Liushen toilet water, so that the mosquito-repelling and itching-relieving compound essential oil provided by the invention has better mosquito-repelling effect than Liushen toilet water, is prepared from natural green essential oil and base oil, has no toxic or side effect, and is healthier, safer and more environment-friendly.
As can be seen by comparing 1-5 groups with 6-17 groups, the repelling time and the effective protection rate of the mosquito-repelling and itching-relieving compound essential oil prepared in the range of the invention are obviously superior to those of the mosquito-repelling and itching-relieving compound essential oil provided by the comparative example, which shows that the compatibility and the efficacy of the invention are obviously enhanced, the essential oils have synergistic interaction, and the mosquito-repelling effect is better.
Test example 2 antipruritic test
1. The experimental subject requires: 760 volunteers with obvious mosquito bites and no other skin diseases are selected, the affected parts with skin itch caused by mosquito bites have more than two parts, the age is 6-70 years old, the affected parts are averagely divided into 19 groups, each group is half of male and female, and other medicines and health care products which have influence on the results are not used during the test period.
2. Grouping: sterile distilled water is smeared on a blank control group, Liushen toilet water provided in a comparative example 13 is smeared on a positive control group, and the mosquito-repelling and itching-relieving compound essential oil provided in examples 1-5 and the mosquito-repelling and itching-relieving compound essential oil provided in comparative examples 1-12 are smeared on an experimental group (1-17 groups).
3. The treatment method comprises the following steps: each patient smears a blank control liquid (sterile distilled water) on one affected part, and smears corresponding mosquito-repelling and itching-relieving medicines on other affected parts, wherein the smearing area is the same as the pruritus area.
4. And (3) evaluating the curative effect:
curing, namely applying the medicine for 1 time, wherein pruritus and redness and swelling disappear immediately or within 10min, and patients do not relapse;
the effect is shown that the pruritus and the red swelling disappear or are obviously relieved within 10min after the liniment is applied for 1 time, and relapse occurs after a plurality of hours, but the relapse does not occur after the liniment is applied again;
effective, the medicine is applied within 10min for 3 times for patients with pruritus and red swelling;
it is ineffective for applying the medicine within 10min for more than 3 times without improving pruritus.
5. As a result: see table 2.
TABLE 2 antipruritic effect of mosquito repellent antipruritic compound essential oil
Figure BDA0002095381750000151
As can be seen from table 2, the total effective rate of relieving itching in examples 1 to 5 of the present invention is more than 82%, and the effect of relieving itching is significant, wherein the total effective rate of example 5 is as high as 97.5%, and the total effective rate of relieving itching in examples 1 to 5 of the present invention is higher than the effects of the positive control group (liushen toilet water) and 6 to 17 groups (comparative examples 1 to 12), which indicates that the mosquito repellent compound essential oil for relieving itching provided by the present invention has an excellent effect of relieving itching by the synergistic effect between the components, and can significantly alleviate the pain of the patient.
Finally, it should be noted that: the above embodiments are only used to illustrate the technical solution of the present invention, and not to limit the same; while the invention has been described in detail and with reference to the foregoing embodiments, it will be understood by those skilled in the art that: the technical solutions described in the foregoing embodiments may still be modified, or some or all of the technical features may be equivalently replaced; and the modifications or the substitutions do not make the essence of the corresponding technical solutions depart from the scope of the technical solutions of the embodiments of the present invention.

Claims (10)

1. The mosquito-repelling and itching-relieving compound essential oil is characterized by comprising the following components in parts by mass: 1.25 parts of citronella essential oil, 0.75 part of eucalyptus citriodora leaf oil, 0.5 part of rosemary essential oil, 0.5 part of basil essential oil, 0.25 part of silver chrysanthemum essential oil, 1 part of elsholtzia essential oil, 0.5 part of amomum cardamomum essential oil, 0.25 part of geranium essential oil and 95 parts of base oil;
the base oil is grape seed oil.
2. The preparation method of the mosquito-repellent itching-relieving compound essential oil disclosed by claim 1 is characterized by comprising the following steps of:
respectively crushing and sieving citronella, eucalyptus citriodora leaves, rosemary, basil, silverweed chrysanthemum, elsholtzia, amomum cardamomum and geranium to obtain crude medicinal powder, respectively soaking and distilling to obtain essential oil, and finally uniformly mixing citronella essential oil, eucalyptus citriodora leaves essential oil, rosemary essential oil, basil essential oil, silverweed chrysanthemum essential oil, elsholtzia essential oil, cardamom essential oil, geranium essential oil and base oil to obtain the mosquito-repelling and itching-relieving compound essential oil.
3. The preparation method of the mosquito-repelling and itching-relieving compound essential oil according to claim 2, wherein in the sieving step, the selected screen mesh is a No. 5 sieve.
4. The preparation method of the mosquito-repelling and itching-relieving compound essential oil according to claim 2, wherein in the distillation step, the essential oil is prepared by a steam distillation method, and the distillation time is 6-10 hours.
5. The preparation method of the mosquito-repelling itching-relieving compound essential oil according to claim 2, wherein the distillation time is 8 hours.
6. The preparation method of the mosquito-repelling and itching-relieving compound essential oil according to claim 2, wherein in the soaking step, distilled water is adopted to soak the crude medicinal powder, and the mass ratio of the crude medicinal powder to the distilled water is 1: 8-12.
7. The preparation method of the mosquito-repelling and itching-relieving compound essential oil as claimed in claim 6, wherein the mass ratio of the crude medicinal powder to distilled water is 1: 10.
8. The application of the mosquito-repellent itching-relieving compound essential oil disclosed by claim 1 in preparing mosquito-repellent itching-relieving articles.
9. A mosquito-repelling and itching-relieving article, which is characterized by comprising the mosquito-repelling and itching-relieving compound essential oil of claim 1.
10. The article for repelling mosquitoes and relieving itching according to claim 9, which comprises sachets, sustained release hanging tablets, sprays, aerosols, creams and nano-emulsions.
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