CN101711238A - 1,3-二羟基取代的苯基酰胺葡糖激酶激活剂 - Google Patents
1,3-二羟基取代的苯基酰胺葡糖激酶激活剂 Download PDFInfo
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- CN101711238A CN101711238A CN200880019467A CN200880019467A CN101711238A CN 101711238 A CN101711238 A CN 101711238A CN 200880019467 A CN200880019467 A CN 200880019467A CN 200880019467 A CN200880019467 A CN 200880019467A CN 101711238 A CN101711238 A CN 101711238A
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- 125000004385 trihaloalkyl group Chemical group 0.000 description 1
- GXPHKUHSUJUWKP-UHFFFAOYSA-N troglitazone Chemical compound C1CC=2C(C)=C(O)C(C)=C(C)C=2OC1(C)COC(C=C1)=CC=C1CC1SC(=O)NC1=O GXPHKUHSUJUWKP-UHFFFAOYSA-N 0.000 description 1
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Classifications
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- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D277/56—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
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- A—HUMAN NECESSITIES
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- A61P9/12—Antihypertensives
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6536—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having nitrogen and sulfur atoms with or without oxygen atoms, as the only ring hetero atoms
- C07F9/6539—Five-membered rings
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
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- Molecular Biology (AREA)
- Urology & Nephrology (AREA)
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- Biochemistry (AREA)
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- Oncology (AREA)
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- AIDS & HIV (AREA)
- Tropical Medicine & Parasitology (AREA)
- Psychiatry (AREA)
- Hospice & Palliative Care (AREA)
- Child & Adolescent Psychology (AREA)
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- Physical Education & Sports Medicine (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US94309207P | 2007-06-11 | 2007-06-11 | |
US60/943,092 | 2007-06-11 | ||
PCT/US2008/066510 WO2008154563A1 (en) | 2007-06-11 | 2008-06-11 | 1, 3 - dihydroxy substituted phenylamide glucokinase activators |
Publications (1)
Publication Number | Publication Date |
---|---|
CN101711238A true CN101711238A (zh) | 2010-05-19 |
Family
ID=39713941
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN200880019467A Pending CN101711238A (zh) | 2007-06-11 | 2008-06-11 | 1,3-二羟基取代的苯基酰胺葡糖激酶激活剂 |
Country Status (5)
Country | Link |
---|---|
US (1) | US8222285B2 (nl) |
EP (1) | EP2170852A1 (nl) |
JP (1) | JP2010529203A (nl) |
CN (1) | CN101711238A (nl) |
WO (1) | WO2008154563A1 (nl) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2016112863A1 (zh) * | 2015-01-14 | 2016-07-21 | 中国科学院上海药物研究所 | N-取代-3,5-二取代苯甲酰胺类化合物及其制备方法和应用 |
Families Citing this family (22)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP2170852A1 (en) | 2007-06-11 | 2010-04-07 | Bristol-Myers Squibb Company | 1, 3 - dihydroxy substituted phenylamide glucokinase activators |
MX2010001784A (es) | 2007-08-13 | 2010-03-15 | Metabasis Therapeutics Inc | Activadores novedosos de la glucocinasa. |
DK2477629T3 (en) * | 2009-09-17 | 2016-08-22 | Univ Vanderbilt | SUBSTITUTED HETEROARYLAMIDANALOGER AS mGluR5 allosteric modulators NEGATIVE AND METHODS OF MAKING AND USE THEREOF |
US9180127B2 (en) | 2009-12-29 | 2015-11-10 | Dana-Farber Cancer Institute, Inc. | Type II Raf kinase inhibitors |
WO2011095997A1 (en) | 2010-02-08 | 2011-08-11 | Advinus Therapeutics Private Limited | Benzamide compounds as glucokinase activators and their pharmaceutical application |
WO2011107494A1 (de) | 2010-03-03 | 2011-09-09 | Sanofi | Neue aromatische glykosidderivate, diese verbindungen enthaltende arzneimittel und deren verwendung |
CN102959076B (zh) | 2010-03-31 | 2015-09-16 | 斯克里普斯研究所 | 重编程细胞 |
US8530413B2 (en) | 2010-06-21 | 2013-09-10 | Sanofi | Heterocyclically substituted methoxyphenyl derivatives with an oxo group, processes for preparation thereof and use thereof as medicaments |
TW201221505A (en) | 2010-07-05 | 2012-06-01 | Sanofi Sa | Aryloxyalkylene-substituted hydroxyphenylhexynoic acids, process for preparation thereof and use thereof as a medicament |
TW201215387A (en) | 2010-07-05 | 2012-04-16 | Sanofi Aventis | Spirocyclically substituted 1,3-propane dioxide derivatives, processes for preparation thereof and use thereof as a medicament |
TW201215388A (en) | 2010-07-05 | 2012-04-16 | Sanofi Sa | (2-aryloxyacetylamino)phenylpropionic acid derivatives, processes for preparation thereof and use thereof as medicaments |
WO2013037390A1 (en) | 2011-09-12 | 2013-03-21 | Sanofi | 6-(4-hydroxy-phenyl)-3-styryl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors |
EP2760862B1 (en) | 2011-09-27 | 2015-10-21 | Sanofi | 6-(4-hydroxy-phenyl)-3-alkyl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors |
EP3071568A1 (en) | 2013-11-19 | 2016-09-28 | Vanderbilt University | Substituted imidazopyridine and triazolopyridine compounds as negative allosteric modulators of mglur5 |
US9533982B2 (en) | 2014-03-20 | 2017-01-03 | Vanderbilt University | Substituted bicyclic heteroaryl carboxamide analogs as mGluR5 negative allosteric modulators |
US9550778B2 (en) | 2014-10-03 | 2017-01-24 | Vanderbilt University | Substituted 6-aryl-imidazopyridine and 6-aryl-triazolopyridine carboxamide analogs as negative allosteric modulators of mGluR5 |
JP6861166B2 (ja) | 2015-03-27 | 2021-04-21 | ダナ−ファーバー キャンサー インスティテュート, インコーポレイテッド | サイクリン依存性キナーゼの阻害剤 |
KR102513342B1 (ko) | 2016-07-22 | 2023-03-22 | 브리스톨-마이어스 스큅 컴퍼니 | 글루코키나제 활성화제 및 그의 사용 방법 |
EP3534899B1 (en) | 2016-11-03 | 2022-06-01 | Corvus Pharmaceuticals, Inc. | Compounds and methods for modulating interleukin-2-inducible t-cell kinase |
US11174253B2 (en) | 2017-08-02 | 2021-11-16 | Alphala Co., Ltd. | Compound and pharmaceutical composition containing the same |
US20210017174A1 (en) | 2018-03-07 | 2021-01-21 | Bayer Aktiengesellschaft | Identification and use of erk5 inhibitor |
CN111446449B (zh) * | 2020-03-10 | 2021-07-09 | 西安交通大学 | 一种多电子传输钒基氧代氟磷酸钠电池材料及其制备方法 |
Family Cites Families (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5594016A (en) | 1992-12-28 | 1997-01-14 | Mitsubishi Chemical Corporation | Naphthalene derivatives |
AU1083499A (en) | 1997-10-21 | 1999-05-10 | Pharmacia & Upjohn Company | Thiadiazoles amides useful as antiinflammatory agents |
US6022884A (en) * | 1997-11-07 | 2000-02-08 | Amgen Inc. | Substituted pyridine compounds and methods of use |
DE19851421A1 (de) * | 1998-11-07 | 2000-05-11 | Boehringer Ingelheim Pharma | Neue Pyrimidine, deren Herstellung und Verwendung |
US6548529B1 (en) | 1999-04-05 | 2003-04-15 | Bristol-Myers Squibb Company | Heterocyclic containing biphenyl aP2 inhibitors and method |
TWI302149B (en) | 1999-09-22 | 2008-10-21 | Bristol Myers Squibb Co | Substituted acid derivatives useful as antiodiabetic and antiobesity agents and method |
US6414002B1 (en) | 1999-09-22 | 2002-07-02 | Bristol-Myers Squibb Company | Substituted acid derivatives useful as antidiabetic and antiobesity agents and method |
IL144507A0 (en) | 2000-07-31 | 2002-05-23 | Pfizer Prod Inc | Use of glycogen phosphorylase inhibitors to inhibit tumor growth |
SE0102764D0 (sv) * | 2001-08-17 | 2001-08-17 | Astrazeneca Ab | Compounds |
BRPI0622262A2 (pt) | 2005-07-09 | 2011-08-09 | Astrazeneca Ab | composto, composição farmacêutica, uso de um composto ou um sal farmaceuticamente aceitável do mesmo, e, processo para a preparação de um composto |
US7910747B2 (en) * | 2006-07-06 | 2011-03-22 | Bristol-Myers Squibb Company | Phosphonate and phosphinate pyrazolylamide glucokinase activators |
US7888504B2 (en) | 2006-07-06 | 2011-02-15 | Bristol-Myers Squibb Company | Glucokinase activators and methods of using same |
EP2170852A1 (en) | 2007-06-11 | 2010-04-07 | Bristol-Myers Squibb Company | 1, 3 - dihydroxy substituted phenylamide glucokinase activators |
JP2010534722A (ja) | 2007-07-27 | 2010-11-11 | ブリストル−マイヤーズ スクイブ カンパニー | 新規グルコキナーゼ活性化薬およびその使用方法 |
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2008
- 2008-06-11 EP EP08770668A patent/EP2170852A1/en not_active Withdrawn
- 2008-06-11 JP JP2010512313A patent/JP2010529203A/ja not_active Withdrawn
- 2008-06-11 US US12/663,807 patent/US8222285B2/en active Active
- 2008-06-11 WO PCT/US2008/066510 patent/WO2008154563A1/en active Application Filing
- 2008-06-11 CN CN200880019467A patent/CN101711238A/zh active Pending
Cited By (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2016112863A1 (zh) * | 2015-01-14 | 2016-07-21 | 中国科学院上海药物研究所 | N-取代-3,5-二取代苯甲酰胺类化合物及其制备方法和应用 |
CN105837599A (zh) * | 2015-01-14 | 2016-08-10 | 中国科学院上海药物研究所 | N-取代-3,5-二取代苯甲酰胺类化合物及其制备方法和应用 |
CN107108656A (zh) * | 2015-01-14 | 2017-08-29 | 中国科学院上海药物研究所 | N‑取代‑3,5‑二取代苯甲酰胺类化合物及其制备方法和应用 |
CN107108656B (zh) * | 2015-01-14 | 2019-11-05 | 中国科学院上海药物研究所 | N-取代-3,5-二取代苯甲酰胺类化合物及其制备方法和应用 |
Also Published As
Publication number | Publication date |
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US20100179121A1 (en) | 2010-07-15 |
EP2170852A1 (en) | 2010-04-07 |
JP2010529203A (ja) | 2010-08-26 |
WO2008154563A1 (en) | 2008-12-18 |
US8222285B2 (en) | 2012-07-17 |
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