CN101698038B - Paster for treating cancer pain and preparation method thereof - Google Patents
Paster for treating cancer pain and preparation method thereof Download PDFInfo
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- CN101698038B CN101698038B CN2009102293129A CN200910229312A CN101698038B CN 101698038 B CN101698038 B CN 101698038B CN 2009102293129 A CN2009102293129 A CN 2009102293129A CN 200910229312 A CN200910229312 A CN 200910229312A CN 101698038 B CN101698038 B CN 101698038B
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Abstract
The invention relates to a paster for treating cancer pain and a preparation method thereof, belonging to the field of traditional Chinese medicine plaster. The paster for treating cancer pain is prepared from the following components in certain weight proportions: brucea javanica oil emulsion, cantharis, artificial ox gallstone, draconis sanguis, rhizoma corydalis, notoginseng, prepared nux vomica, datura flower, oldenlandia diffusa, menthol, prepared pangolin scales, artificial musk, codonopsis pilosula, jujube meat, glue of tortoise plastron and antler glue. The preparation method comprises thefollowing steps: using codonopsis pilosula, datura flower and oldenlandia diffusa to prepare a traditional Chinese medicine extract, adding jujube meat and brucea javanica oil emulsion, stirring uniformlyinto a paste substance; then adding the two glues of tortoise plastron and antler, adding water to decoct into a colloid substance; processing artificial ox gallstone, draconis sanguis, rhizoma corydalis, notoginseng, nux vomica and prepared pangolin scales into fine powders; adding the fine powders cantharis, menthol and artificial musk to the traditional Chinese medicine extract; and stirring uniformly to obtain the paster for treating cancer pain. The effective ingredient extract of the traditional Chinese medicine is obtained by soaking and heating the traditional Chinese medicine materials, and has fast absorption so as to exert the potency of medicine and no anaphylactic reaction.
Description
Technical field
The invention belongs to the Chinese medicine plaster field, particularly a kind of crust cloth cream for the treatment of cancerous pain.The invention still further relates to the preparation method of this crust cloth cream.
Background technology
Cancerous pain is the most common and symptom the most rambunctious of cancer patient, it also is the principal element that influences patients ' life quality most, very big misery that the patient is caused in view of cancer pain and the difficulty in the treatment, The World Health Organization (WHO) has classified the control of cancerous pain as one of global cancer unified plan research emphasis.The method that present clinical treatment cancerous pain generally adopts is that WHO widelys popularize " three ladder medicine analgesias " scheme, the erious adverse reaction of analgesics though the method curative effect is relatively more definite, life-time service easily cause addiction and dependency to use analgesic effect not good enough because of the part patient simultaneously.Chinese medicine has been obtained very good effect on treatment alleviation cancerous pain in recent years, but prescription confusion, general main employing traditional black plaster, black plaster by the leaded class of oils and fats substrate, it is adjuvant that there is Plumbum preparatium the inside, there are poor heat resistance, facilitation, easily pollute the defective of skin and medicated clothing, have lead poisoning to cause the side effect of skin allergy.Simultaneously the rubber plaster made such as traditional rubber or Corium elephatis extractum, zinc oxide, lanoline, vaseline is because this cream contains more zinc oxide, is prone to that skin is redly itched, anaphylaxis.Therefore to contain additive more for cream, and the few curative effect of the medicament contg of symptomatic treatment is also little desirable.
The innovation and creation content
The object of the present invention is to provide a kind of effective ingredient extractum is that substrate, animal glue are the crust cloth cream of the treatment cancerous pain of gelationus pure Chinese crude drug making, the curative effect height.
The invention still further relates to the preparation method of the crust cloth cream of this treatment cancerous pain.
The present invention is achieved in that
The crust cloth cream of treatment cancerous pain is characterized in that the component of making active ingredient by its weight proportion is: Fructus Bruceae cream 1～8, Mylabris 0.5～5, artificial Calculus Bovis 0.5～5, Sanguis Draxonis 0.5～5, Rhizoma Corydalis 0.5～8, Radix Notoginseng 0.5～5, Semen Strychni (processed) 0.1～3, Flos Daturae 0.5～5, Herba Hedyotidis Diffusae 1～3, Mentholum 0.5～3, Squama Manis preparata 1～3, artificial Moschus 0.05～2, Radix Codonopsis 1～6, Fructus Jujubae 5～15, Colla Plastri Testudinis 1～4 and Colla cornus cervi 1～4.
The preparation method of the crust cloth cream of preparation treatment cancerous pain, it is characterized in that: (1) gets Flos Daturae, Herba Hedyotidis Diffusae and Radix Codonopsis by weight, put in the cream pot and add water, the weight ratio of medicine, water is 1: 3, slow fire is endured and is boiled back 30 minutes, medicine is pulled out, behind the medical filtration decontamination, reenter in the pot, endure with slow fire and drip into pearl; (2) the Fructus Jujubae decortication core, jujube pulp and Fructus Bruceae cream add by weight in the cream pot and stir; (3) artificial Calculus Bovis, Sanguis Draxonis, Radix Notoginseng, Rhizoma Corydalis, Semen Strychni, Squama Manis preparata are pulverized 100 order sieve fine powders by weight shared electric mill, go in the cream pot; (4) weight ratio Colla Plastri Testudinis, broken the putting in the cream pot of Colla cornus cervi electricity consumption pulverizing are added water, the weight ratio of glue, water is 1: 10, and slow fire was endured 30 minutes, in the flame-out cream pot that cools; (5) Mentholum, Mylabris, artificial Moschus, are stirred in the adding cream pot with porcelain porphyrize powder by weight separately; (6) with coating machine cream is coated onto on the elastic force cloth, thickness is 40mm, cuts into the finished product crust cloth cream of 6 * 10cm.
The crust cloth cream that the present invention treats cancerous pain is by Chinese medicine animal glue, and Colla Plastri Testudinis, Colla cornus cervi are the crust cloth cream of plaster substrate, are different from the crust cloth cream with chemical colloid such as Resina persicae etc.Its advantage is:
1, be that the crust cloth patch of substrate has affinity interaction with animal glue to human body, the efficacy of a drug absorbs fast, does not have irritated reaction, and it is convenient that sticking firmly taking off pasted, Testudinis deer two glue be the medicine of treatment cancerous pain be again plaster substrate of the present invention, saved the medicine of treatment.
2, having avoided traditional plaster vegetable oil to endure black plaster and the another kind of adjuvant that explosive material method adds adjuvant Plumbum preparatium is the untoward reaction of zinc oxide adhesive plaster, easily irritated, easily is infected with the defective of medicated clothing.
3, to treat the crust cloth cream of cancerous pain be the extractum of water soluble drug effective ingredient in the present invention, be the middle pharmaceutically active ingredient extractum that Chinese crude drug is soaked the gained of heating, the important step of having avoided the traditional black plaster manufacturing is Chinese crude drug to be put into high-temperature vegetable oil endure fried dried-up to medical material, can reduce the effective ingredient of medicine, thereby influence the therapeutic effect of medicine.
Chinese medicine has been obtained very good effect on treatment alleviation cancerous pain in recent years, enumerated the instant effect of a lot of treatment by Chinese herbs cancerous pain as (recent developments of Chinese medicine alleviation cancerous pain) Wang Hongwei Zibo hospital of office that Shandong journal of Chinese medicine was reported in the 22 volume third phases of March in 2003, long action time, untoward reaction is few, and can alleviate the untoward reaction of Western medicine, medicine source foot, cost is low, and wide application value is arranged.And point out the circulation of qi promoting silt of Chinese medicine, dissipating phlegm and resolving masses, heat-clearing and toxic substances removing, detumescence relieves the pain, and the medicine of QI invigorating and body resistance strengthening all has the effect of alleviating cancerous pain preferably, enumerated the square medicine of a lot of inner disease outer treats in " inner disease outer treat complete works ", outer obedient plaster is wherein arranged, and advantage is: method is simple, and patient is acceptant, avoided that oral medicine easily injures one's stomach, kidney, the defective of untoward reaction has been arranged.Particularly " internal disease external treatment of Chinese medicine " write by Wu Shuhua, Xu Zhaoshan, the People's Health Publisher publishes, the 9th page, the umbilicus therapy, the plaster card applies SHENQUE acupoint, is that the efficacy of a drug absorbs soon the acupuncture point of instant effect, therefore the cave is that the human body twelve regular channels converges part, be subcutaneous blood capillary at most, the closeest, the most shallow place.
Treatment mechanism:
Technical solution of the present invention, be based on the pathogenetic correct understanding of modern Chinese medicine to cancerous pain, embody reducing swelling and alleviating pain, alleviated cancerous pain Zhi Qiben, eliminating evil (silt, dissipating phlegm and resolving masses, heat-clearing and toxic substances removing, dredge the meridian passage at once gasify) sets upright (being the strongly invigorating QI and blood negative and positive) and controls its mark, presses down cancer the dispel Therapeutic Principle of its root of tumor that contracts.Reuse Fructus Bruceae cream inducing cancer cell and wither and insult deadly, see list of references " CHINA JOURNAL OF CHINESE MATERIA MEDICA " volume the 8th phase thesis topic " Fructus Bruceae cream is induced the apoptotic research of HL-60 " Augusts 28 in 2003 for details.Mylabris suppresses growth of tumour cell and division, make tumor dwindle and disappear, see 946 pages of Yan Zhenghua chief editors of list of references " Chinese materia medica " for details, the editorial member collects especially forever, Deng Weijun, Lv Lan smokes, and the People's Health Publisher publishes, in August, 1991 front page, the front page second impression in August nineteen ninety-five " the Mylabris function suppresses growth of tumour cell and division makes tumor dwindle or disappear ".Institute of Materia Medica,Chinese Academy of Medical Sciences, Wang Fang, Cao Yu, Liu Hongyan, Fu Zhaodi.With artificial Calculus Bovis, Sanguis Draxonis is minister, in order to heat-clearing and toxic substances removing, and activating blood circulation to dissipate blood stasis, detumescence relieves the pain.Assistant relieves the pain with the Rhizoma Corydalis circulation of qi promoting, Radix Notoginsengization silt hemostasis, and detumescence relieves the pain, the Mentholum heat-clearing and toxic substances removing, detumescence relieves the pain, and the Semen Strychni dissipating phlegm and resolving masses relieves the pain, and the Flos Daturae dredge the meridian passage relieves the pain, the Herba Hedyotidis Diffusae heat-clearing and toxic substances removing, inducing diuresis to remove edema relieves the pain, and helps the ministerial drug detumescence altogether and relieves the pain.Use the Radix Codonopsis QI invigorating, Fructus Jujubae is enriched blood, the Colla Plastri Testudinis nourishing YIN, and the Colla cornus cervi YANG invigorating, four flavor strongly invigorating QI and blood negative and positive, it is flourish that the sufficient then internal organs meridians of negative and positive of qi and blood are got, and it is painful to get Rong Ze, and the then anti-evil ability of healthy energy foot is strong, makes cancer ache morning and dispels, and health is health early.Tonify deficiency is set upright the anticancer transfer of method energy, see 43 volumes, 2 phase Niu Hongmei Shanghai Univ. of Traditional Chinese Medicine guidance in (Journal of Traditional Chinese Medicine) February in 2002 for details: Liu Jia Hunan Affiliated Hospital of Shanghai Univ. of Traditional Chinese Medicine oncology, exercise question (the anticancer transfer progress of Chinese medicine) has been enumerated the effect that a lot of tonify deficiency drug supporting healthy energies can have good anticancer transfer.The skilful use Squama Manis has and penetrates the merit of assaulting fortified position, and the power that Moschus has fragrance to penetrate makes a concerted effort to be carrier, carries the through sick institute of all medicines, plays eliminating pathogenic factor for supporting vital QI altogether, and it is painful to alleviate cancer, presses down the cancer tumor that contracts, the merit of anticancer transfer.Add that plaster method for making of the present invention exempted oil and endured explosive material and alcohol-pickled medical material, easily reduce the technology of medical material effective ingredient, thus the present invention have the efficacy of a drug big, absorb fast, short treating period, good effect that curative effect is high.
Pharmacology analysis:
The painful pathology of cancer is qi stagnation blood stasis, and expectorant coagulates, and pyretic toxicity pents up, and blockage of main and collateral channels is then painful, and the painful with the passing of time yang blood and qi of cancer loses empty, and it is then painful flourishly to support the internal organs meridians, and general rule is painful is the domination of pathogen, and Rong Ze is painful for weakened body resistance, and the domination of pathogen is weakened body resistance, and then cancer is painful day by day increases the weight of.The rule of treatment is: eliminating evil double setting upright, that is: and circulation of qi promoting silt, dissipating phlegm and resolving masses, heat-clearing and toxic substances removing, detumescence relieves the pain, dredge the meridian passage and eliminating evil, makes through ruton and obstructed painful dispelling.Tonification yang blood and qi and setting upright makes the internal organs meridians get flourish and not flourish removing bitterly.Press down cancer contract tumor control its root therefore we use Fructus Bruceae cream, function be that inducing cancer cell withers and insults death.List of references (CHINA JOURNAL OF CHINESE MATERIA MEDICA) 28 the 8th phases of volume of August in 2003; thesis topic (Fructus Bruceae cream is induced the apoptotic research of HL-60) institute of Materia Medica,Chinese Academy of Medical Sciences Wang Fang; Cao Yu, Liu Hongyan, Fu Zhaodi; suppress growth of tumour cell and division with the Mylabris function; make tumor dwindle or disappear, the 946th page of list of references (Chinese materia medica), Yan Zhenghua chief editor; outstanding flourish volume of editorial member; Deng Weijun, Lv Lan smokes, People's Health Publisher's in August, 1991 front page; front page secondary printing in August nineteen ninety-five; two flavors dwindle carcinoma in order to apoptosis, and reducing swelling and alleviating pain Zhi Qiben joins the artificial Calculus Bovis; Sanguis Draxonis is a minister, in order to heat-clearing and toxic substances removing; activating blood circulation to dissipate blood stasis; detumescence relieves the pain, and eliminating pathogenic factor for supporting vital QI is controlled its mark assistant and relieved the pain with the Rhizoma Corydalis circulation of qi promoting, and Radix Notoginsengization silt hemostasia and detumescence relieves the pain; the Mentholum clearing heat, releasing toxin, removing swelling relieves the pain; the Semen Strychni dissipating phlegm and resolving masses relieves the pain, and the Flos Daturae dredge the meridian passage relieves the pain, and Herba Hedyotidis Diffusae heat-clearing and toxic substances removing inducing diuresis to remove edema relieves the pain; help ministerial drug altogether, detumescence relieves the pain.Use the Radix Codonopsis QI invigorating, Fructus Jujubae is enriched blood, the Colla Plastri Testudinis nourishing YIN, and the Colla cornus cervi YANG invigorating, four flavors are adjuvant drug altogether, the strongly invigorating QI and blood negative and positive, it is flourish that the sufficient then internal organs meridians of negative and positive of qi and blood are got, and it is painful to get Rong Ze, and the then anti-evil ability of healthy energy foot is strong, makes cancer ache morning and dispels, and health is health early.Tonify deficiency is set upright method can anticancer transfer see 43 volumes, 2 phase author Niu Hongmei Shanghai Univ. of Traditional Chinese Medicine guidance in (Journal of Traditional Chinese Medicine) February in 2002 for details: Liu Jia Hunan Affiliated Hospital of Shanghai Univ. of Traditional Chinese Medicine oncology thesis topic (Chinese medicine anti metastasis progress) has been enumerated a lot of tonify deficiency drug supporting healthy energies good anticancer transferance.The skilful use Squama Manis penetrates the merit of merit heavily fortified point and the power that artificial Moschus's fragrance penetrates, and makes a concerted effort to be carrier.Carry the through sick institute of all medicines, play the function of reducing swelling and alleviating pain, eliminating pathogenic factor for supporting vital QI, alleviation cancerous pain, tumor, anticancer tumor metastasis altogether but cancer contracts.
The specific embodiment
Below in conjunction with embodiment the present invention is elaborated.
The technical solution used in the present invention is the Chinese medical concrete of being made by Radix Codonopsis, Flos Daturae, Herba Hedyotidis Diffusae, adds jujube pulp, Fructus Bruceae cream, stirs, as cream matter; Add Testudinis, deer two glue again; add water and be boiled into colloid; by artificial Calculus Bovis, Sanguis Draxonis, Rhizoma Corydalis, Radix Notoginseng, Semen Strychni, Squama Manis preparata is fine powder; Mylabris, Mentholum, each porphyrize powder of artificial Moschus; add in the Chinese medical concrete; stir with blender and to dispose, the ratio of weight and number of above-mentioned each Chinese crude drug is:
Fructus Bruceae cream 1～8, Mylabris 0.5～5, artificial Calculus Bovis 0.5～5, Sanguis Draxonis 0.5～5, Rhizoma Corydalis 0.5～8, Radix Notoginseng 0.5～5, Semen Strychni (processed) 0.1～3, Flos Daturae 0.5～5, Herba Hedyotidis Diffusae 1～3, Mentholum 0.5～3, Squama Manis preparata 1～3, artificial Moschus 0.05～2, Radix Codonopsis 1～6, Fructus Jujubae 5～15, Colla Plastri Testudinis 1～4 and Colla cornus cervi 1～4.
The formula optimization parts by weight proportioning of preparation medicine of the present invention is:
Fructus Bruceae cream 2, Mylabris 1, artificial Calculus Bovis 2, Sanguis Draxonis 2, Rhizoma Corydalis 1, Radix Notoginseng 1, Semen Strychni (processed) 1, Flos Daturae 1, Herba Hedyotidis Diffusae 1, Mentholum 1, Squama Manis preparata 1, artificial Moschus 0.1, Radix Codonopsis 1, Fructus Jujubae 5, Colla Plastri Testudinis 2 and Colla cornus cervi 2.
Embodiment 1
Concrete prescription of the present invention is:
Fructus Bruceae cream 200g, Mylabris 100g, artificial Calculus Bovis 200g, Sanguis Draxonis 200g, Rhizoma Corydalis 100g, Radix Notoginseng 100g, Semen Strychni (processed) 100g, Flos Daturae 100g, Herba Hedyotidis Diffusae 100g, Mentholum 100g, Squama Manis preparata 100g, artificial Moschus 10g, Radix Codonopsis 100g, Fructus Jujubae 500g, Colla Plastri Testudinis 200g and Colla cornus cervi 200g.
The preparation method that the present invention clings to cloth cream is:
1, get Flos Daturae 100g, Herba Hedyotidis Diffusae 100g by weight, Radix Codonopsis 100g is put in the cream pot and is added water, adding water 900g slow fire endures and boils back 30 minutes, medicine is pulled out, and medicinal liquid reenters interior the enduring with slow fire of pot and drips into pearl and be advisable after 100 order nets filter the back decontamination.Fructus Jujubae is removed the peel, examined, stir in jujube pulp 500g and the Fructus Bruceae cream 200g adding pot.
2, weight ratio artificial Calculus Bovis, each 200g of Sanguis Draxonis, Radix Notoginseng, Rhizoma Corydalis, Semen Strychni, the shared electric mill of each 100g of Squama Manis preparata are pulverized 100 order sieve fine powders, go in the cream pot.
3, weight ratio Colla Plastri Testudinis, broken the putting in the cream pot of each 200g electricity consumption pulverizing of Colla cornus cervi are added water, add water 4000g slow fire and endure and be melted into scattered paste shape in 30 minutes, sticking hands becomes the silkworm silk shape to be advisable, and goes in the blender after flame-out the cooling to stir altogether with extractum.
4, at last Mentholum 100g, each independent porcelain porphyrize powder of using of Mylabris (removing sufficient wing glutinous rice parching to brown) 100g, artificial Moschus 10g, stirs with blender in the adding cream pot.
5, with coating machine cream is coated onto on the elastic force cloth, thickness is 0.4mm, is cut into the finished product crust cloth cream of 6 * 10cm with cutting machine, in the double-deck tinfoil band of packing into, and one bag two, seal standbyly, make Ben Babu cream.
Using method:
The cancerous pain at these various positions of plaster treatment is attached to each a slice of the painful position (Ashi point) of patient's umbilicus portion (SHENQUE acupoint) and cancer, changes once in three days, and 10 times 30 days is a course of treatment.Especially obedient Ashi point is can make the efficacy of a drug sick institute that go directly because of pasting the cancer pain part, so the efficacy of a drug absorbs soon instant effect.
Embodiment 2
Other prescription of the present invention is: Fructus Bruceae cream 800g, Mylabris 500g, artificial Calculus Bovis 500g, Sanguis Draxonis 500g, Rhizoma Corydalis 800g, Radix Notoginseng 500g, Semen Strychni (processed) 300g, Flos Daturae 500g, Herba Hedyotidis Diffusae 200g, Mentholum 300g, Squama Manis preparata 200g, artificial Moschus 200g, Radix Codonopsis 300g, Fructus Jujubae 1000g, Colla Plastri Testudinis 400g and Colla cornus cervi 400g.
Embodiment 3
Other prescription of the present invention is: Fructus Bruceae cream 100g, Mylabris 50g, artificial Calculus Bovis 50g, Sanguis Draxonis 50g, Rhizoma Corydalis 50g, Radix Notoginseng 50g, Semen Strychni (processed) 10g, Flos Daturae 50g, Herba Hedyotidis Diffusae 300g, Mentholum 50g, Squama Manis preparata 300g, artificial Moschus 5g, Radix Codonopsis 600g, Fructus Jujubae 1500g, Colla Plastri Testudinis 100g and Colla cornus cervi 100g.
Clinical trial:
Be checking medicine of the present invention, the applicant carried out following clinical trial in 2004-2008 in Shandong Province's Liaocheng City institute of traditional Chinese medicine:
1, data and method
1.1 clinical data: painful patient's 160 examples of cancer are from Liaocheng City institute of traditional Chinese medicine, conditions of patients all in the above the People's Hospital of city-level or tumor section hospital by nuclear magnetic resonance, NMR, strengthen CT, B ultrasonic scanning, cancerous cell laboratory examination and make a definite diagnosis.
1.2 Therapeutic Method: painful patient's 160 examples of cancer are test group, with the present invention's treatment " treatment cancerous pain crust cloth medicine "
Matched group adopts efficacy result in " A Lin pastes the 178 routine clinical researches of treatment cancer pain ", and " A Lin pastes the 178 routine clinical researches of treatment cancer pain " is the paper that Henan College Of Traditional Chinese Medicine hospital and the Yellow River central hospital deliver in the 43rd 3 phases of volume of Journal of Traditional Chinese Medicine in March, 2002.A Lin pastes and is made up of Resina Ferulae, Sanguis Draxonis, Borneolum Syntheticum, Mentholum, Cortex Cinnamomi, Rhizoma Corydalis, Flos Caryophylli, Herba Asari, Rhizoma Chuanxiong, Moschus etc.College of traditional Chinese medicine institute of Chinese materia medica, effluent south provides (preparation D7071)
1.3 cancerous pain grade scale: have not yet to see and draft as follows with reference to each tame standard and the painful clinical manifestation of cancer about cancerous pain classification unified standard:
Slightly: though the patient has pain to stand, it is painful or sharp to be intermittent account, heavily presses alleviation of pain, and painful area does not generally influence sleep and has a meal based on tumor site, can orthobiosis
Moderate: patient's pain is obvious, is seriality, does not subtract lastingly, and is sharp or attack painfully, fixing do not move, heavily very by pain, and near position or the enlargement of lymph node is painful is impatient at emitting to, need take opioid drug and remove, the influence sleep is had a meal and orthobiosis.
Severe: sharp ache, tenderness or near position and the enlargement of lymph node are painful, can not fall asleep, with positive position or autonomic nervous dysfunction's performance, can not orthobiosis, need relieve the pain with heavy dose of opioid drug.
The entry-into-force time standard relieves the pain: count time till the conscious pain relief of patient with treatment time.
1.4 criterion of therapeutical effect: draft: 1, alleviate fully: the pain complete obiteration with reference to clinical relevant criterion, the sleep life of having a meal recovers normal 2, part and alleviates: pain obviously alleviates, the sleep life of having a meal is normal substantially 3, stable: pain does not have obvious alleviation, but do not increase the weight of 4 yet, progress: pain is not only alleviated and is increased the weight of on the contrary.
2, therapeutic outcome
2.1 test group and matched group are selected the comparative analysis of case ordinary circumstance
Through X2 check p＞0.05, illustrate that two groups of situations are approaching substantially, have its comparability.
2.2 two groups of sick bit comparison analyses of cancerous pain
Through X2 check p＞0.05; Compare p＞0.05 between the group of position
Conclusion: balanced comparable between the painful position of cancer between two groups
2.3 two groups of painful rank comparative analysiss of cancer
＊p＜0.001
＊＊p＜0.05
Approaching substantially through X2 check p＞two groups of situations of 0.05 explanation, comparability is arranged
2.4 two groups of efficacy result comparative analysiss
2.4.1 two groups of painful remission rate comparative analysiss of cancer
There were significant differences for painful complete remission rate of cancer and obvious remission rate between two groups, and test group is better than matched group
＊p＜0.001
＊＊p＜0.005
2.4.2 two groups of painful effective percentage comparative analysiss that relieve the pain of cancer
| Group | Total effective routine number | Total effective rate | Total produce effects example number | Total obvious effective rate |
| Matched group | 170 examples | 95.5％ | 135 | 75.84％ |
| Test group | 159 examples | 99.4％ | 142 | 86.1％ |
There were significant differences for total effective rate and total obvious effective rate between two groups, and test group is better than matched group
2.5 two groups of entry-into-force time comparative analysiss that relieve the pain
| Group | The example number | 5～10 minutes | 10～20 minutes | 20 minutes with | On average relieve the pain |
| The person of coming into force | The clock person of coming into force | On the person of coming into force | Entry-into-force time | ||
| Matched group | 68 examples | 20 examples | 34 examples | 14 examples | 16.37 divide |
| Test group | 66 examples | 28 examples | 36 examples | 6 examples | 11.74 divide |
＊p＞0.001
＊＊p＜0.005
Two groups of relieve the pain entry-into-force time and the entry-into-force times that on average relieve the pain, there were significant differences, and test group is better than matched group
3, concrete case
59 years old address of case 1. Wang Yue prunus mume (sieb.) sieb.et zucc.s woman: shop, Liaocheng City Dongchangfu District road junction township Wang Yuehecun came to go to a doctor on June 7th, 1999, and readme in person: dysphagia pain has foreign body sensation unbearably in the larynx closely over the past half year, and the back is strengthened CT to Liaocheng City institute of traditional Chinese medicine and made a definite diagnosis esophageal carcinoma.Tcm inspection: purplish tongue is dark, and there is the congestion speckle on the tongue limit, and yellow and greasy fur is thick, and pulse-taking is heavy unable, and shallow complexion is dim colourless, is diagnosed as esophagus cancerous pain moderate.
Method of treatment: external application the present invention clings to cloth cream, paste each 1 at patient's SHENQUE acupoint and painful area esophagus place (Ashi point), changed once in 3 days, 10 times is 1 course of treatment, further consultation after 30 days, and the feed pain relief is swallowed in patient's readme, can drink foods such as noodles, it is gradually good to sleep, and it is light red to see its complexion, and pale tongue with thin fur is greasy in vain, the floating number of pulse condition is thin, continue with 1 course of treatment of treatment cancerous pain crust cloth cream, the patient comes institute's readme after 1 month, can eat hard food, white steamed bread, cannot not swallow painfully, can walk about down, strengthen the CT further consultation: tumor focus two footpath products are less than 50%.Continue with consolidating curative effect 1 course of treatment, follow up a case by regular visits to the patient after half a year and recover normally, the sleep activity of having a meal is as usual.
66 years old address of case 2. bent red moral men: come to go to a doctor on August calendar year 2001 17 in the Liaocheng City Dongchangfu District Hou Ying Zhen Qu village, family members Dai Shu: in last year the patient got gastric cancer provincial hospital operate on the treatment do not feel any better yet, existing gastric cancer place pain unbearably, dripping sweat during pain, often tell sticking expectorant, can not take food sleep disorder, limitation of activity, two is just difficult.Inspection: complexion is dark yellow, the dark pastiness of tongue, and there is the congestion speckle on the tongue limit, and tongue is white yellow alternate, slightly thick, deep and stringy pulse is unable, and the abdominal part edema that swells has the spider reticulation blood streak, and tenderness is strengthened CT and made a definite diagnosis, gastric cancer is diffused into the esophagus hypomere, has become to soak into shape, and area 3 * 5cm makes a definite diagnosis gastric cancer pain severe.Method of treatment: external application the present invention clings to cloth cream, paste each 1 at the painful place of patient's SHENQUE acupoint and gastric cancer (Ashi point), changed 1 time in 3 days, 10 times 30 days is 1 course of treatment, families of patients comes to get crust cloth cream after 30 days, state: patient's food that noodles and cookies digest well of taking food, pain can be stood, and defecating still, drying is difficult to resolve, doctor's advice continues with treatment cancerous pain crust cloth cream, follow up a case by regular visits to after 6 courses of treatment: the patient can stand the relieving dyspepsia thing, can fall asleep, and defecation is normal, the energy out-of-bed activity, the gastric cancer position is pain no longer, comes institute's check, and is facial light red, pale tongue with white fur, moderate pulse is strengthened CT check tumor and do not had increase diffusion again, and is stable.
The husky town of 60 years old address of the full mother and daughter of case 3. Wang Gui Liaocheng City Dongchangfu District Middle St is gone to a doctor son Dai Shu on January 16th, 2004: mother urinates recently and is with blood dark red, and stench flavor being arranged, little abdominal distention is painful, can not fall asleep, the low grade fever is often arranged, the CT of Liaocheng City institute of traditional Chinese medicine makes a definite diagnosis uterus carcinoma.Tcm inspection: yellow complexion is colourless, is slow in action, and the dim indentations at the margin of the tongue of tongue, the congestion speckle, tongue is greyish white greasy, and the deep pulse stringy and thready pulse is unable, is diagnosed as uterus cancerous pain moderate.Method of treatment: external application the present invention clings to cloth cream, paste each 1 of patient's SHENQUE acupoint and cancer pain place (Ashi point), changed in 3 days 1 time, 30 days is 1 course of treatment, checks after 6 courses of treatment, patient's readme: urine does not have the blood streak, the sleep activity of having a meal is normal, and lower abdomen pain disappears, and inspection: complexion is light red glossy, it is movable sensitive to walk, and tongue fur is light red.Strengthen CT examination: the uterus is full, and profile is clear, and tumor disappears, and follows up a case by regular visits to alive after half a year.
4, conclusion:
4.1 in view of above-mentioned pathology and pharmacology theoretic knowledge to cancerous pain, formulated reducing swelling and alleviating pain Zhi Qiben, eliminating pathogenic factor for supporting vital QI is controlled its mark, the Therapeutic Principle of tumor Zhi Qigen but cancer contracts, therefore the present invention selects for use Fructus Bruceae cream inducing cancer cell to wither and insults death, Mylabris suppresses growth of tumour cell and division, tumor cell is dwindled or disappear to be monarch.It is minister that adapted artificial Calculus Bovis, Sanguis Draxonis relieve the pain with heat-clearing and toxic substances removing, activating blood circulation to dissipate blood stasis, detumescence.The monarch and his subjects play altogether and press down the merit that cancer relieves the pain, the merit that assistant relieves the pain with Rhizoma Corydalis, Radix Notoginseng, Semen Strychni, Flos Daturae, Mentholum, Herba Hedyotidis Diffusae circulation of qi promoting silt, heat-clearing and toxic substances removing, dredge the meridian passage, detumescence, with Radix Codonopsis, Fructus Jujubae, Colla Plastri Testudinis, the Colla cornus cervi tonify deficiency is set upright, anti-heresy relieves the pain function, can alleviate cancer pain, can stop cancerometastasis, prolong patient's life span, improve patient's life quality.The present invention has changed the big extraction process of conventional pastes pharmaceutically active ingredient loss, adopts scientific technology to make, and Chinese medicine water solublity extractum has improved curative effect.Clinical through for many years, the present invention of development clings to cloth cream meticulously, combine with advanced person's dosage form with the extraction process of science, and be the basis of the special efficacy of this plaster.
4.2 this plaster is to be plaster substrate by Colla Plastri Testudinis, Colla cornus cervi, simultaneously two glue are treated the medicine of cancer pain again in the side of being, can the strongly invigorating QI and blood negative and positive, it is not painful to make the internal organs meridians get Rong Ze, increased the curative effect of principal agent greatly, it is to be substrate with animal glue that the present invention treats the painful crust cloth cream of cancer, is better than doing with chemical raw material the crust cloth cream of substrate greatly, is the peculiar major reason of this plaster curative effect.
4.3 this plaster treatment is rapid-action to Cancer pain Therapy, generally takes effect at 11.74 minutes, makes pain relief, this be other plaster can not than.The present invention's " crust cloth cream of treatment cancerous pain " is a test group, curative effect relatively with matched group " A Lin cream treatment cancer pain 178 examples " for treatment cancerous pain 160 examples, at total effective rate and the obvious effective rate of alleviating cancerous pain notable difference is arranged, test group obviously is better than matched group.
Make the curative effect difference course of treatment 4.4 the crust cloth cream of treatment cancerous pain generally is weight, the course of disease length with pain, ailing patient's onset heavy, that the course of disease is long is slow, should adhere to medication, up to recovery from illness.
4.5 adjuvants such as the present invention is not leaded, zinc oxide, so it has overcome side effect such as existing plaster lead poisoning, zinc oxide anaphylaxis.Substrate of the present invention is the oleaginous base that water solublity has replaced existing plaster generally to adopt, and has therefore also overcome the defective of polluting skin and medicated clothing.
Claims (3)
1. the crust cloth cream of treatment cancerous pain is characterized in that the raw material composition of making active ingredient by its weight proportion is: Fructus Bruceae cream 1～8, Mylabris 0.5～5, artificial Calculus Bovis 0.5～5, Sanguis Draxonis 0.5～5, Rhizoma Corydalis 0.5～8, Radix Notoginseng 0.5～5, Semen Strychni (processed) 0.1～3, Flos Daturae 0.5～5, Herba Hedyotidis Diffusae 1～3, Mentholum 0.5～3, Squama Manis preparata 1～3, artificial Moschus 0.05～2, Radix Codonopsis 1～6, Fructus Jujubae 5～15, Colla Plastri Testudinis 1～4 and Colla cornus cervi 1～4.
2. crust cloth cream according to claim 1 is characterized in that the weight proportion that each raw material is formed is: Fructus Bruceae cream 2, Mylabris 1, artificial Calculus Bovis 2, Sanguis Draxonis 2, Rhizoma Corydalis 1, Radix Notoginseng 1, Semen Strychni (processed) 1, Flos Daturae 1, Herba Hedyotidis Diffusae 1, Mentholum 1, Squama Manis preparata 1, artificial Moschus 0.1, Radix Codonopsis 1, Fructus Jujubae 5, Colla Plastri Testudinis 2 and Colla cornus cervi 2.
3. prepare the preparation method of the crust cloth cream of the described treatment cancerous pain of claim 1, it is characterized in that:
(1) get Flos Daturae, Herba Hedyotidis Diffusae and Radix Codonopsis by weight, put in the cream pot and add water, the weight ratio of medicine, water is 1: 3, and slow fire is endured and boiled back 30 minutes, and medicine is pulled out, behind the medical filtration decontamination, reenters in the pot, endures with slow fire and drips into pearl;
(2) the Fructus Jujubae decortication core, jujube pulp and Fructus Bruceae cream add by weight in the cream pot and stir;
(3) artificial Calculus Bovis, Sanguis Draxonis, Radix Notoginseng, Rhizoma Corydalis, Semen Strychni, Squama Manis preparata are pulverized 100 order sieve fine powders by weight shared electric mill, go in the cream pot;
(4) weight ratio Colla Plastri Testudinis, broken the putting in the cream pot of Colla cornus cervi electricity consumption pulverizing are added water, the weight ratio of glue, water is 1: 10, and slow fire was endured 30 minutes, in the flame-out cream pot that cools;
(5) Mentholum, Mylabris, artificial Moschus, are stirred in the adding cream pot with porcelain porphyrize powder by weight separately;
(6) with coating machine cream is coated onto on the elastic force cloth, thickness is 40mm, cuts into the finished product crust cloth cream of 6 * 10cm.
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN102302663B (en) * | 2011-09-08 | 2012-12-26 | 王俭 | Chinese medicine for treating primary carcinoma of liver |
| CN105727156A (en) * | 2014-12-10 | 2016-07-06 | 王令喜 | Cancer inhibiting and pain relieving cataplasm and preparation method thereof |
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| CN102836378B (en) * | 2012-08-06 | 2014-03-12 | 汪甬伟 | Oral liquid capable of relieving cholecystitis pain |
| CN104721658A (en) * | 2015-02-27 | 2015-06-24 | 国焕臣 | External plaster for treating cancer pain and preparation method thereof |
| CN105748746A (en) * | 2016-04-28 | 2016-07-13 | 邱定武 | Medical plaster for treating functional disorder after splicing of cut-off tendons and preparation method of medical plaster |
| CN106177801A (en) * | 2016-08-31 | 2016-12-07 | 王兰英 | A kind of cataplasma treating cancerous pain and preparation method thereof |
| CN107823592A (en) * | 2017-11-17 | 2018-03-23 | 河南中医药大学 | A kind of external application anti-tumor Chinese medicine cream |
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| CN101411854A (en) * | 2007-10-16 | 2009-04-22 | 彭丽英 | External use medicament for eliminating cancer, tumor and sore thereof |
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| CN101411854A (en) * | 2007-10-16 | 2009-04-22 | 彭丽英 | External use medicament for eliminating cancer, tumor and sore thereof |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN102302663B (en) * | 2011-09-08 | 2012-12-26 | 王俭 | Chinese medicine for treating primary carcinoma of liver |
| CN105727156A (en) * | 2014-12-10 | 2016-07-06 | 王令喜 | Cancer inhibiting and pain relieving cataplasm and preparation method thereof |
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