CN101695490A - Medicinal composition for treating livestock and poultry cold, preparation method thereof and application thereof - Google Patents
Medicinal composition for treating livestock and poultry cold, preparation method thereof and application thereof Download PDFInfo
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- CN101695490A CN101695490A CN200910305342A CN200910305342A CN101695490A CN 101695490 A CN101695490 A CN 101695490A CN 200910305342 A CN200910305342 A CN 200910305342A CN 200910305342 A CN200910305342 A CN 200910305342A CN 101695490 A CN101695490 A CN 101695490A
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Abstract
The invention discloses a medicinal composition for treating livestock and poultry cold, a preparation method thereof and application thereof and aims to provide the medicinal composition for effectively preventing and controlling the livestock and poultry cold, the preparation method thereof and the application thereof. The medicinal composition for treating the livestock and poultry cold comprises the following components in percentage by weight: 10 to 30 percent of paracetamol, 0.1 to 0.5 percent of chlorpheniramine maleate, 3 to 10 percent of taurine, and the balance of pharmaceutically acceptable adjuvant. When livestock and poultry catch cold, the medicinal composition for treating the livestock and poultry cold quickly relieves poultry hyperthermia, improves enhance resistance and effectively relieves reduced appetite, quickened breath, death and the like of the livestock and poultry caused by livestock and poultry influenza. The medicinal composition can improve laying rate and egg weight, improve daily average feed intake, improve feed conversion rate, alleviate laying peak descending process and reduce egg breakage rate. The medicinal composition can reduce comb temperature, body temperature and breathing rate shortening course of disease of heat stress layer chicken.
Description
Technical field
The present invention relates to a kind of pharmaceutical composition for the treatment of livestock and poultry cold and its production and application.
Background technology
In recent years, poultry occupy very big ratio by the disease that virus causes in the poultry infectious disease, occupy the 2nd by its animal dead rate that causes in all causes of disease, are only second to antibacterial, account for 36.8%.Overwhelming majority virosis is an immunosuppressive disease, causes immunity of organisms to descend, and various mixed infections take place the secondary animal and the depleted syndrome of many tracts (makes whole drove be in immunosuppressive condition; To other cause of disease susceptible, symptom, pathological changes are not true to type after the mixed infection; To the immunne response ability drop of specific vaccine or do not react, cause immuning failure; Whole resistance descends: growth retardation, and constantly fragmentary dead; The secondary multiple infection increases, the conditionality pathogenic bacterium can cause serious disease), sickness rate is in rising trend, particularly over the past two years, poultry bird flu and bird flu secondary or mixed infection sickness rate are very high, the poultry M ﹠ M is sharply risen, bring very big harm for China man livestock and poultry breeding industry.
Chinese herb prevention is adopted in the control of livestock and poultry cold at present mostly, and some classical prescriptions have good effect, but because herbal medicine efficacy is slow, the course of treatment is longer, general medication just can take effect after 35 days, can not be rapidly effective mitigate the disease, the growth of poultry often is subjected to very big influence.
Summary of the invention
The present invention is in order to overcome deficiency of the prior art, to provide a kind of and can rapidly, effectively prevent and treat the pharmaceutical composition of livestock and poultry cold.
Second purpose of the present invention provides a kind of preparation of drug combination method for the treatment of livestock and poultry cold.
The 3rd purpose of the present invention provides a kind of application for the treatment of the pharmaceutical composition of livestock and poultry cold.
The present invention is achieved through the following technical solutions:
A kind of pharmaceutical composition for the treatment of livestock and poultry cold is characterized in that consisting of of percent by weight: acetaminophen 10-30%, chlorphenamine 0.1%-0.5%, taurine 3-10%, surplus is an acceptable accessories.
Wherein, best group becomes: percent acetaminophen 20%, chlorphenamine 0.3%, taurine 5% by weight, surplus is an acceptable accessories.
Described acceptable accessories is at least a in sucrose, lactose, glucose, the water soluble starch.Multiple adjuvant can be by the arbitrary proportion proportioning.
A kind of preparation of drug combination method for the treatment of livestock and poultry cold; it is characterized in that; comprise the steps: acetaminophen, chlorphenamine, taurine and acceptable accessories respectively through powder essence with after sieving; percent is got acetaminophen 10-30%, chlorphenamine 0.1%-0.5%, taurine 3-10% by weight; the acceptable accessories of surplus; mix homogeneously is promptly made the pharmaceutical composition of treatment livestock and poultry cold of the present invention.
A kind of application of pharmaceutical composition in preparation livestock and poultry cold medicine for the treatment of livestock and poultry cold.
The present invention has following technique effect:
The pharmaceutical composition of treatment livestock and poultry cold of the present invention is a compound Western medicine preparation, and acetaminophen wherein is a kind of antipyretic analgesics safely and effectively, works by the hypothalamus thermotaxic centre.Taurine can promote the pituitary hormone secretion; the activation pancreatic function; thereby improve the state of organism endocrine system; to organism metabolism with useful adjusting; and can promote the enhancing of immunity of organisms; have analgesic and antiinflammatory action, reduce body temperature by effect to maincenter 5-ht system or catecholamine system.Chlorphenamine is a histamine antagonist, by to antfhistamine irritated effect, alleviating the symptom of livestock and poultry cold with histamine competition histamine H1-receptor effectively.
When the pharmaceutical composition of treatment livestock and poultry cold of the present invention poultry flu takes place, can alleviate poultry high temperature rapidly, build up resistance, effectively alleviate loss of appetite that the poultry influenza causes poultry, accelerated breathing, death etc.Can increase laying rate, increase egg size, increase per day feed intake, improve food conversion ratio, also can relax the peak descending process of laying eggs, reduce the egg breakage rate.Can reduce hat temperature, body temperature and the breathing rate of heat stress laying hen, shorten the course of disease.
The specific embodiment
Below in conjunction with specific embodiment to the detailed description of the invention.
Acetaminophen, chlorphenamine, taurine and acceptable accessories is standby behind powder essence and mistake 80 mesh sieves respectively.
Embodiment 1
Take by weighing acetyl aminophenol 30 grams, chlorphenamine 0.5 gram, taurine 8 grams, glucose 61.5 grams, mix homogeneously is promptly made the pharmaceutical composition of treatment livestock and poultry cold of the present invention.
Embodiment 2
Take by weighing acetyl aminophenol 25 grams, chlorphenamine 0.3 gram, taurine 10 grams, glucose 64.7 grams, mix homogeneously is promptly made the pharmaceutical composition of treatment livestock and poultry cold of the present invention.
Embodiment 3
Take by weighing acetyl aminophenol 20 grams, chlorphenamine 0.4 gram, taurine 15 grams, glucose 64.6 grams, mix homogeneously is promptly made the pharmaceutical composition of treatment livestock and poultry cold of the present invention.
Embodiment 4
Take by weighing acetyl aminophenol 10 grams, chlorphenamine 0.2 gram, taurine 20 grams, glucose 67.8 grams, mix homogeneously is promptly made the pharmaceutical composition of treatment livestock and poultry cold of the present invention.
Embodiment 5
Take by weighing acetyl aminophenol 30 grams, chlorphenamine 0.3 gram, taurine 10 grams, glucose 59.7 grams, mix homogeneously is promptly made the pharmaceutical composition of treatment livestock and poultry cold of the present invention.
Embodiment 6
Take by weighing acetyl aminophenol 25 grams, chlorphenamine 0.3 gram, taurine 5 grams, sucrose 69.7 grams, mix homogeneously is promptly made the pharmaceutical composition of treatment livestock and poultry cold of the present invention.
Embodiment 7
Take by weighing acetyl aminophenol 20 grams, chlorphenamine 0.2 gram, taurine 8 grams, lactose 51.8 grams, glucose 20 grams, mix homogeneously is promptly made the pharmaceutical composition of treatment livestock and poultry cold of the present invention.
Embodiment 8
Take by weighing acetyl aminophenol 15 grams, chlorphenamine 0.3 gram, taurine 15 grams, water soluble starch 69.7 grams, mix homogeneously is promptly made the pharmaceutical composition of treatment livestock and poultry cold of the present invention.
Embodiment 9
Take by weighing acetyl aminophenol 25 grams, chlorphenamine 0.3 gram, taurine 3 grams, sucrose 50.7 grams, water soluble starch 21 gram mix homogeneously are promptly made the pharmaceutical composition of treatment livestock and poultry cold of the present invention.
Laboratory report:
Laboratory animal:
150 of the ill one-tenth of picked at random chickens are divided into five groups at random by body weight, 30 every group.
A organizes positive matched group, does not give Drug therapy.
The B group is healthy group.
The C group is the ribavirin therapy group, and mix drink: every 5g is used for 100kg water, every day 2 times, logotype 3 days.
Pharmaceutical composition+Lonicerae and Forsythiae Powder treatment the group of the treatment livestock and poultry cold that the D group is made for the embodiment of the invention 5.Wherein, the pharmaceutical composition of the treatment livestock and poultry cold that the embodiment of the invention 5 is made mixes drink: every 5g is used for 100kg water, every day 2 times, logotype 3 days.Lonicerae and Forsythiae Powder mixed feeding: 1000g is used for 200kg material, every day 2 times, logotype 3 days.
The E group is " Lonicerae and Forsythiae Powder " matched group, mixed feeding: every 1000g is used for 200kg material, every day 2 times, logotype 3 days.
The clinical efficacy result of the test is as shown in table 1.
Table 1
| Numbering | Group | Sickness rate % | Mortality rate % | The course of disease |
| ??A | Positive controls | ??33.3(10/30) | ??26.7(8/30) | ??7 |
| ??B | Healthy group | ??0(0/30) | ??0(0/30) | ??0 |
| ??C | The ribavirin therapy group | ??83.3(7/30) | ??16.6(5/30) | ??6 |
| ??D | The pharmaceutical composition of the treatment livestock and poultry cold that the embodiment of the invention 5 is made+Lonicerae and Forsythiae Powder treatment group | ??0(0/30) | ??0(0/30) | ??3 |
| ??E | " Lonicerae and Forsythiae Powder " matched group | ??6.67(2/30) | ??6.67(2/30) | ??5 |
As can be seen from Table 1, this result of the test is analyzed by statistics, the pharmaceutical composition of the treatment livestock and poultry cold that the embodiment of the invention 5 is made+Lonicerae and Forsythiae Powder treatment group and ribavirin matched group difference is (P＜0.01) extremely significantly, the pharmaceutical composition of the treatment livestock and poultry cold that the embodiment of the invention 5 is made+Lonicerae and Forsythiae Powder treatment group and " Lonicerae and Forsythiae Powder " matched group significant difference (P＜0.05).
In addition, test in some chicken farms of Tianjin, the result is as follows:
Tianjin Dong Changtun
The doubtful mild influenza (H9N1) that infected of chicken group, the decline of searching for food, fervescence, cockscomb is blue, spirit is depressed, the foot squama is hemorrhage, and dissect: the glandular stomach mammillitis is hemorrhage, and chicken stomach fat is hemorrhage, and it is hemorrhage to have occurred the Semen Jujubae sample in the intestinal, mortality.The pharmaceutical composition of the treatment livestock and poultry cold that use embodiment 6 makes cooperates Lonicerae and Forsythiae Powder 3 days, and mortality rate descends, the increase of searching for food, all recoveries from illness after 3 days.
Mare Tranquillitatis history village
The symptom of turning one's head individually, the head and neck chatter, the chicken cockscomb meat whisker cyanosis of dying of illness, toe scale drying, have hemorrhage, the decline of searching for food, the dead rising.Dissect: trachea whole process is hemorrhage, and purulent secretion is arranged, and bronchus also has expectorant, the pulmonary venous pleonaemia necrosis, SN, atrophy of thymus gland, the pancreas degeneration, necrosis, mesentery has the petechia, the breastbone inner membrance is hemorrhage, meningorrhagia, the glandular stomach diffuse hemorrhage, the muscular stomach inwall is hemorrhage, the fabricius bursa atrophy, the last doubtful mild influenza of tentative diagnosis (H9N1).
The pharmaceutical composition logotype of the treatment livestock and poultry cold that the use embodiment of the invention 7 is made 4 days suitably cooperated the astragalus polysaccharides logotype 3 days, and chicken group symptom obviously disappears, and mortality has also descended, and the chicken group is controlled.
Claims (5)
1. pharmaceutical composition for the treatment of livestock and poultry cold, it is characterized in that consisting of of percent by weight: acetaminophen 10-30%, chlorphenamine 0.1%-0.5%, taurine 3-10%, surplus is an acceptable accessories.
2. treatment livestock and poultry cold according to claim 1 pharmaceutical composition, it is characterized in that consisting of of percent by weight: acetaminophen 20%, chlorphenamine 0.3%, taurine 5%, surplus are acceptable accessories.
3. the pharmaceutical composition of treatment livestock and poultry cold according to claim 1 and 2 is characterized in that described acceptable accessories is at least a in sucrose, lactose, glucose, the water soluble starch.
4. the preparation of drug combination method of the described treatment livestock and poultry cold of claim 1; it is characterized in that comprising the steps: with acetaminophen, chlorphenamine, taurine and acceptable accessories respectively through powder essence with after sieving; percent is got acetaminophen 10-30%, chlorphenamine 0.1%-0.5%, taurine 3-10% by weight; the acceptable accessories of surplus; mix homogeneously is promptly made the pharmaceutical composition of treatment livestock and poultry cold of the present invention.
5. the application of the pharmaceutical composition of each described treatment livestock and poultry cold in preparation livestock and poultry cold medicine among the claim 1-3.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN200910305342A CN101695490A (en) | 2009-08-07 | 2009-08-07 | Medicinal composition for treating livestock and poultry cold, preparation method thereof and application thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN200910305342A CN101695490A (en) | 2009-08-07 | 2009-08-07 | Medicinal composition for treating livestock and poultry cold, preparation method thereof and application thereof |
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| CN101695490A true CN101695490A (en) | 2010-04-21 |
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| CN200910305342A Pending CN101695490A (en) | 2009-08-07 | 2009-08-07 | Medicinal composition for treating livestock and poultry cold, preparation method thereof and application thereof |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2014020167A3 (en) * | 2012-08-02 | 2014-06-26 | L'oreal | Dye composition comprising at least one sulfonic compound and a thickening polymer, dyeing process and suitable device |
| CN105287477A (en) * | 2015-09-16 | 2016-02-03 | 四川伴农动保生物技术有限公司 | Carbasalate calcium powder and preparation method thereof |
-
2009
- 2009-08-07 CN CN200910305342A patent/CN101695490A/en active Pending
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2014020167A3 (en) * | 2012-08-02 | 2014-06-26 | L'oreal | Dye composition comprising at least one sulfonic compound and a thickening polymer, dyeing process and suitable device |
| CN105287477A (en) * | 2015-09-16 | 2016-02-03 | 四川伴农动保生物技术有限公司 | Carbasalate calcium powder and preparation method thereof |
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Application publication date: 20100421 |