CN101690824A - On-line sterilizer of damp and hot vapour sterilization cabinet - Google Patents
On-line sterilizer of damp and hot vapour sterilization cabinet Download PDFInfo
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- CN101690824A CN101690824A CN200910145160A CN200910145160A CN101690824A CN 101690824 A CN101690824 A CN 101690824A CN 200910145160 A CN200910145160 A CN 200910145160A CN 200910145160 A CN200910145160 A CN 200910145160A CN 101690824 A CN101690824 A CN 101690824A
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Abstract
The invention discloses an on-line sterilizer of a damp and hot vapour sterilization cabinet, which has simple structure and low cost and does not cause halfway sterilization or excessive sterilization of the filter element of an air filter. The on-line sterilizer of the invention comprises an air filter, an intake pipeline, an exit pipeline, a steam admission pipeline and a drainage pipeline, wherein the intake pipeline and the exit pipeline are respectively connected with the inlet and the outlet of the air filter, and the drainage pipeline is communicated with the inlet of the air filter; an intake control valve and an exist control valve are respectively connected in series in the intake pipeline and the exit pipeline; a drainage control valve and a drainage filter are connected in series in the drainage pipeline; an intake valve and a vapour filter are connected in series in the intake pipeline; the outlet of the intake pipeline is divided into two paths, wherein one path enters a pure vapour valve via the filter to be communicated with the outlet of the air filter, and the other path enters the pure vapour valve via an inner chamber to be communicated with the outlet of the exit control valve; and the inlet of the drainage pipeline is provided with a temperature detecting probe and a pressure controller. The invention can adopt three different sterilization modes and brings great convenience for users to use.
Description
Technical field
The present invention relates to wet-hot steam sterilization cabinet, refer more particularly to the online bactericidal unit of wet-hot steam sterilization cabinet.
Background technology
After the China's entry into the WTO, the standard of pharmaceuticals industry and GMP standard basic absorption the pertinent regulations of European Union's standard and U.S. FDA standard.Therefore, the medicine instrument industry manufacture and design the requirement that application standard all need satisfy standard, strengthen the processing quality and the performance of product from the production link, to comply with the national standard requirements, absorb foreign advanced standard, satisfy domestic standard and improve.At present, some domestic biological studies in one's power some biological pharmaceutical factories when buying moist heat sterilization cabinet, along with national GMP code requirement at the purchase requirement of corresponding raising to the sterilization cabinet.In the online bactericidal unit of present wet-hot steam sterilization cabinet, admission unit and QI invigorating unit are separate, and the behaviour in service of the unitary air filter of QI invigorating has not met the requirement of some high-end biological engineering and the GMP of country of R﹠D institution authentication.For this reason, the way of taking at present has two kinds: a kind of is to pull down air filter cashier's office in a shop from sterilization, air filter then, it carried out high-temperature sterilization, owing to need contact high temperature, under the uncontrollable situation of temperature, be very easy to cause the filter element sterilization thoroughly or excessively not sterilize, excessively cause the filter element distortion after the sterilization easily, filtering accuracy does not reach phenomenons such as requirement, and operate also ten minutes trouble, work efficiency is not high; Another kind of then the additional facilities that needs a cover separately air filter to be carried out online sterilization, structure is quite complicated, its sterilization process is: steam enters after air filter downstream (filter outlet) carries out hydrophobic through the upstream of air filter (import of filter), after sterilization finishes, carry out drying by clean compressed air or nitrogen, this has just increased the manufacturing cost and the use cost of whole wet-hot steam sterilization cabinet greatly, and, this online bactericidal unit, its sterilization method to air filter is more single, uses very inconvenient.
Summary of the invention
Technical problem to be solved by this invention is: provide a kind of simple in structure, cost is low and the filter element sterilization that can not cause air filter not thoroughly or the online bactericidal unit of the wet-hot steam of excessively sterilization sterilization cabinet.
For solving the problems of the technologies described above, the technical solution used in the present invention is: the online bactericidal unit of wet-hot steam sterilization cabinet, comprise: air filter, respectively with the advancing of air filter, admission line and outlet pipe that outlet links to each other, admission pipeline and the drain water piping that is connected with the import of air filter, be serially connected with air intake control valve and leaving air control valve in admission line and the outlet pipe respectively, be serially connected with hydrophobic control valve and hydrophobic filter in the drain water piping, be serially connected with inlet valve and vapor filter in the admission pipeline, exit at the admission pipeline is divided into two-way, one the tunnel advances pure steam valve via filter is connected with the outlet of air filter, another road via inner room advance pure steam valve with and the outlet of leaving air control valve be connected; Be provided with temperature probe and pressure controller in the porch of described drain water piping.
Described air intake control valve, leaving air control valve and hydrophobic control valve and filter advance pure steam valve and inner room and advance pure steam valve and be autocontrol valve, and described inlet valve is a manual ball valve.
The invention has the beneficial effects as follows: the present invention is simple in structure, operates also very simply, makes manufacturing cost and use cost all lower, has improved work efficiency greatly; And, can control the sterilising temp and the steam pressure of air filter, can not cause the filter element sterilization of air filter thoroughly or excessively not sterilize; And can adopt three kinds of different sterilization methods to air filter according to user's needs, greatly facilitate user's use.
Description of drawings
Fig. 1 is the theory structure sketch map that the wet-hot steam sterilization cabinet of making-up air device of the present invention is installed.
Fig. 2 is a local theory structure sketch map among Fig. 1.
The specific embodiment
Below in conjunction with accompanying drawing, describe specific embodiments of the present invention in detail.
As depicted in figs. 1 and 2, the online bactericidal unit of wet-hot steam sterilization cabinet of the present invention, comprise: air filter G, respectively with the advancing of air filter G, admission line and outlet pipe that outlet is connected, admission pipeline and the drain water piping that is connected with the import of air filter G, be serially connected with air intake control valve ZC3 and leaving air control valve ZC2 in admission line and the outlet pipe respectively, be serially connected with hydrophobic control valve ZC6 and hydrophobic filter S3 in the drain water piping, be serially connected with inlet valve J2 and vapor filter G2 in the admission pipeline, exit at the admission pipeline is divided into two-way, one the tunnel advances pure steam valve ZC4 via filter is connected with the outlet of air filter G, another road via inner room advance pure steam valve ZC5 with and the outlet of leaving air control valve ZC2 be connected; Be provided with temperature probe W2 and pressure controller DB1 in the porch of described drain water piping; Described air intake control valve ZC3 and leaving air control valve ZC2, hydrophobic control valve ZC6 and filter advance pure steam valve ZC4 and inner room and advance pure steam valve ZC5 and be autocontrol valve, and described inlet valve J2 is a manual ball valve.
Wet-hot steam sterilization cabinet of the present invention is installed can adopt three kinds of online sterilization methods that air filter G is carried out sterilization:
1, with after sterilization cabinet inner room communicates carries out the while sterilization method, this sterilization method is that the article in air filter G and the sterile chamber are sterilized simultaneously, air filter G and sterile chamber do as a whole, when sterilizing in the sterile chamber, also air filter G are sterilized.Referring to shown in Figure 2, its concrete work process is: before the operation, each autocontrol valve all is in closed condition, setting according to program, after sterilization cabinet chuck reaches preheating time, vacuum pump P, leaving air control valve ZC2 and vacuum control valve ZC7 open simultaneously, sterile chamber and air filter G are carried out evacuation to discharge the cold air among sterile chamber and the air filter G, to guarantee the temperature homogeneity of sterile chamber, after evacuation reaches set point number, close vacuum pump P, vacuum control valve ZC7, start the hydrophobic control valve ZC13 in sterile chamber, inner room advances pure steam valve ZC5 and hydrophobic control valve ZC6, after temperature that the temperature probe W2 at the survey temperature control head W1 at the minimum point for measuring temperature place of sterile chamber and the minimum point for measuring temperature of air filter G place records reaches the sterilising temp that sets, begin to count sterilization time, after arriving the setting sterilization time, close the hydrophobic control valve ZC13 in sterile chamber, inner room advances pure steam valve ZC5 and hydrophobic control valve ZC6, open the steam among exhaust-control valve ZC8 discharging sterile chamber and the air filter G, after pressure is reduced to setting pressure, close exhaust-control valve ZC8, and open vacuum control valve ZC7, filter element to sterilizing article in the sterile chamber and air filter G carries out vacuum drying, after reaching setting-up time (because vacuum drying sterilization cabinet inner room has negative pressure to exist), close vacuum control valve ZC7, and open air intake control valve ZC3, import clean atmospheric air by the air filter G that was sterilized to the sterile chamber, after making pressure in the sterile chamber reach the safe pressure that opens the door, whole sterilizing program finishes.
2, heat up simultaneously and sterilize with the sterilization cabinet, this sterilization method is that air filter G can carry out simultaneously with the sterilization of sterilization cabinet, pass through program setting, also can start air filter G evening, to guarantee that the air of carrying later in sterilization is clean in the sterile chamber, in the sterilization of sterilization cabinet, G sterilizes to air filter.Referring to shown in Figure 2, its concrete work process is: before the operation, each autocontrol valve all is in closed condition, setting according to program, after sterilization cabinet chuck reaches preheating time, vacuum pump P, leaving air control valve ZC2 and vacuum control valve ZC7 open simultaneously, sterile chamber and air filter G are carried out evacuation to discharge the cold air among sterile chamber and the air filter G, to guarantee the temperature homogeneity of sterile chamber, after evacuation reaches set point number, close vacuum pump P, leaving air control valve ZC2 and vacuum control valve ZC7, start the hydrophobic control valve ZC13 in sterile chamber, filter advances pure steam valve ZC4, inner room advances pure steam valve ZC5 and hydrophobic control valve ZC6, after temperature that the temperature probe W2 at the survey temperature control head W1 at the minimum point for measuring temperature place of sterile chamber and the minimum point for measuring temperature of air filter G place records reaches the sterilising temp that sets, begin to count sterilization time, after reaching the setting sterilization time, close the hydrophobic control valve ZC13 in sterile chamber, inner room advances pure steam valve ZC5 and hydrophobic control valve ZC6, open the steam among exhaust-control valve ZC8 discharging sterile chamber and the air filter G, after pressure is reduced to setting pressure, close exhaust-control valve ZC8, and open vacuum control valve ZC7, filter element to sterilizing article in the sterile chamber and air filter G carries out vacuum drying, after reaching setting-up time (because vacuum drying sterilization cabinet inner room has negative pressure to exist), close vacuum control valve ZC7, and open air intake control valve ZC3, import clean atmospheric air by the air filter G that was sterilized to the sterile chamber, after making pressure in the sterile chamber reach the safe pressure that opens the door, whole sterilizing program finishes.
3, the independent sterilization of air filter G self, this mode are when inner room is unsterilised or idle, and empty filter made device G is carried out online sterilization.This online sterilization method does not need to carry out simultaneously with sterile chamber's sterilization, does not therefore just need top dual mode after the chuck preheating, and inner room just begins evacuation.Referring to shown in Figure 2, its concrete work process is: before the operation, each autocontrol valve all is in closed condition, setting according to program, open filter and advance pure steam valve ZC4, hydrophobic control valve ZC6, in air filter G, directly import pure steam, pass through pressure, the dual control of temperature is weighed and is decided interior pressure of air filter G and the minimum temperature of air filter G, to guarantee the uniformity of temperature, sterilising temp is laggard goes into the sterilization stage reaching, when reach set sterilization time after, close filter and advance pure steam valve ZC4 and hydrophobic control valve ZC6, open leaving air control valve ZC2 and vacuum control valve ZC7 carries out evacuation to air filter G, with the delay steam among the deaeration filter G, after reaching setting-up time, close vacuum control valve ZC7, and open air intake control valve ZC3 and in the sterile chamber, import pure air by air filter G, pressure in the sterile chamber is gone up to normal pressure, get back to the preceding state of operation.
In sum, wet-hot steam sterilization cabinet of the present invention being installed will get well much than the effect of pulling down, also separately air filter G is sterilized the online sterilization of air filter G; And, saved the dismounting installation time, improved work efficiency; And prevented secondary pollution to sterilizing article in the sterile chamber.Satisfied the requirement of national GMP authentication specifications fully.
Claims (2)
1. the online bactericidal unit of wet-hot steam sterilization cabinet, comprise: air filter and respectively with the advancing of air filter, admission line and outlet pipe that outlet links to each other, be serially connected with air intake control valve and leaving air control valve in admission line and the outlet pipe respectively, it is characterized in that: the drain water piping that also includes the admission pipeline and be connected with the import of air filter, be serially connected with hydrophobic control valve and hydrophobic filter in the drain water piping, be serially connected with inlet valve and vapor filter in the admission pipeline, exit at the admission pipeline is divided into two-way, one the tunnel advances pure steam valve via filter is connected with the outlet of air filter, another road via inner room advance pure steam valve with and the outlet of leaving air control valve be connected; Be provided with temperature probe and pressure controller in the porch of described drain water piping.
2. online bactericidal unit according to claim 1, it is characterized in that: described air intake control valve, leaving air control valve and hydrophobic control valve and filter advance pure steam valve and inner room and advance pure steam valve and be autocontrol valve, and described inlet valve is a manual ball valve.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2009101451604A CN101690824B (en) | 2009-10-12 | 2009-10-12 | On-line sterilizer of damp and hot vapour sterilization cabinet |
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| CN2009101451604A CN101690824B (en) | 2009-10-12 | 2009-10-12 | On-line sterilizer of damp and hot vapour sterilization cabinet |
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| CN101690824A true CN101690824A (en) | 2010-04-07 |
| CN101690824B CN101690824B (en) | 2013-11-27 |
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Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103394106A (en) * | 2013-07-30 | 2013-11-20 | 山东新华医疗器械股份有限公司 | Steam sterilizer and sterilization process |
| CN104888243A (en) * | 2015-05-15 | 2015-09-09 | 楚天科技股份有限公司 | Sterile filter online sterilization device and method |
| CN105146235A (en) * | 2015-10-08 | 2015-12-16 | 青海泰柏特生物科技有限公司 | Method for killing microorganisms on surfaces of dry wolfberry fruits through circulating water vapor |
| CN105341617A (en) * | 2015-10-08 | 2016-02-24 | 青海泰柏特生物科技有限公司 | Circulation steam sterilization method for Chinese wolfberry fruit powder |
| CN109304062A (en) * | 2017-07-26 | 2019-02-05 | 上海至纯洁净系统科技股份有限公司 | A kind of improved pipe-line system for setting air filter and its sterilizing methods |
| CN109901648A (en) * | 2017-12-11 | 2019-06-18 | 杭州科腾生物制品有限公司 | A kind of control method of gel pre-encapsulated injector final sterilization system |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN201093467Y (en) * | 2007-11-02 | 2008-07-30 | 马庆华 | Pure steam generator |
| CN201519313U (en) * | 2009-10-12 | 2010-07-07 | 张家港市华菱医疗设备制造有限公司 | On-line sterilization device for moist heat steam sterilization cabinets |
-
2009
- 2009-10-12 CN CN2009101451604A patent/CN101690824B/en active Active
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN201093467Y (en) * | 2007-11-02 | 2008-07-30 | 马庆华 | Pure steam generator |
| CN201519313U (en) * | 2009-10-12 | 2010-07-07 | 张家港市华菱医疗设备制造有限公司 | On-line sterilization device for moist heat steam sterilization cabinets |
Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103394106A (en) * | 2013-07-30 | 2013-11-20 | 山东新华医疗器械股份有限公司 | Steam sterilizer and sterilization process |
| CN104888243A (en) * | 2015-05-15 | 2015-09-09 | 楚天科技股份有限公司 | Sterile filter online sterilization device and method |
| CN105146235A (en) * | 2015-10-08 | 2015-12-16 | 青海泰柏特生物科技有限公司 | Method for killing microorganisms on surfaces of dry wolfberry fruits through circulating water vapor |
| CN105341617A (en) * | 2015-10-08 | 2016-02-24 | 青海泰柏特生物科技有限公司 | Circulation steam sterilization method for Chinese wolfberry fruit powder |
| CN109304062A (en) * | 2017-07-26 | 2019-02-05 | 上海至纯洁净系统科技股份有限公司 | A kind of improved pipe-line system for setting air filter and its sterilizing methods |
| CN109901648A (en) * | 2017-12-11 | 2019-06-18 | 杭州科腾生物制品有限公司 | A kind of control method of gel pre-encapsulated injector final sterilization system |
| CN109901648B (en) * | 2017-12-11 | 2021-02-09 | 杭州科腾生物制品有限公司 | Control method of final sterilization system of gel pre-filled and sealed syringe |
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| CN101690824B (en) | 2013-11-27 |
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Address after: Suzhou City, Jiangsu province 215632 gold town Zhangjiagang city Nansha sanlijia Road, Zhangjiagang Hualing Medical Equipment Co Ltd Patentee after: Zhangjiagang Hualing Medical Equipment Co Ltd Address before: 215632, Nansha, Jiangsu Province, Zhangjiagang Town, three gold road Patentee before: Zhangjiagang Hualing Medical Equipment Manufacturing Co., Ltd. |
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