CN101690824B - On-line sterilizer of damp and hot vapour sterilization cabinet - Google Patents
On-line sterilizer of damp and hot vapour sterilization cabinet Download PDFInfo
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- CN101690824B CN101690824B CN2009101451604A CN200910145160A CN101690824B CN 101690824 B CN101690824 B CN 101690824B CN 2009101451604 A CN2009101451604 A CN 2009101451604A CN 200910145160 A CN200910145160 A CN 200910145160A CN 101690824 B CN101690824 B CN 101690824B
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Abstract
The invention discloses an on-line sterilizer of a damp and hot vapour sterilization cabinet, which has simple structure and low cost and does not cause halfway sterilization or excessive sterilization of the filter element of an air filter. The on-line sterilizer of the invention comprises an air filter, an intake pipeline, an exit pipeline, a steam admission pipeline and a drainage pipeline, wherein the intake pipeline and the exit pipeline are respectively connected with the inlet and the outlet of the air filter, and the drainage pipeline is communicated with the inlet of the air filter; an intake control valve and an exist control valve are respectively connected in series in the intake pipeline and the exit pipeline; a drainage control valve and a drainage filter are connected in series in the drainage pipeline; an intake valve and a vapour filter are connected in series in the intake pipeline; the outlet of the intake pipeline is divided into two paths, wherein one path enters a pure vapour valve via the filter to be communicated with the outlet of the air filter, and the other path enters the pure vapour valve via an inner chamber to be communicated with the outlet of the exit control valve; and the inlet of the drainage pipeline is provided with a temperature detecting probe and a pressure controller. The invention can adopt three different sterilization modes and brings great convenience for users to use.
Description
Technical field
The present invention relates to moist heat steam sterilization cabinets, refer more particularly to the online bactericidal unit of moist heat steam sterilization cabinets.
Background technology
After China's entry into the WTO, the standard of pharmaceuticals industry and GMP standard basic absorption the pertinent regulations of European Union's standard and U.S. FDA standard.Therefore, the medicine instrument industry manufacture and design the requirement that application standard all needs to meet standard, from the production link, strengthen processing quality and the performance of product, to comply with the national standard requirements, absorb foreign advanced standard, meet domestic standard and improve.At present, some domestic biological studies in one's power some biological pharmaceutical factories when buying moist heat sterilization cabinet, along with national GMP code requirement at the purchase requirement of corresponding raising to sterilizing cabinet.In the online bactericidal unit of current moist heat steam sterilization cabinets, admission unit and QI invigorating unit are separate, and the behaviour in service of the air filter of QI invigorating unit has not met the requirement of some high-end biological engineering and the GMP of country of R&D institution authentication.For this reason, the way of taking at present has two kinds: a kind of is to pull down air filter from sterilizing cabinet, then, it is carried out to high-temperature sterilization, because air filter need contact high temperature, in the uncontrollable situation of temperature, be very easy to cause filter element sterilizing not thorough or excessively sterilizing, the excessively sterilizing rear filter element distortion that easily causes, filtering accuracy does not reach the phenomenons such as requirement, and the operation also very the trouble, work efficiency is not high; Another kind of need a set ofly separately air filter to be carried out to online sterilizing additional facilities, the structure very complex, its sterilization process is: steam enters and is undertaken hydrophobic by air filter downstream (filter outlet) through the upstream of air filter (import of filter), after sterilizing end, by clean compressed air or nitrogen, carry out drying, this has just increased manufacturing cost and the use cost of whole moist heat steam sterilization cabinets greatly, and, this online bactericidal unit, its sterilization method to air filter is more single, uses very inconvenient.
Summary of the invention
Technical problem to be solved by this invention is: provide a kind of simple in structure, cost is low and can not cause the filter element of air filter sterilizing not thoroughly or the online bactericidal unit of excessively sterilizing moist heat steam sterilization cabinets.
For solving the problems of the technologies described above, the technical solution used in the present invention is: the online bactericidal unit of moist heat steam sterilization cabinets, comprise: air filter, respectively with the advancing of air filter, admission line and outlet pipe that outlet is connected, admission pipeline and the drain water piping be connected with the import of air filter, in admission line and outlet pipe, be serially connected with respectively air intake control valve and leaving air control valve, in drain water piping, be serially connected with hydrophobic control valve and hydrophobic filter, in the admission pipeline, be serially connected with inlet valve and vapor filter, exit at the admission pipeline is divided into two-way, one tunnel is advanced pure steam valve via filter and is connected with the outlet of air filter, another road is connected via the outlet that inner room advances pure steam valve and leaving air control valve, in the porch of described drain water piping, be provided with temperature probe and pressure controller.
Described air intake control valve, leaving air control valve and hydrophobic control valve and filter advance pure steam valve and inner room and advance pure steam valve and be autocontrol valve, and described inlet valve is manual ball valve.
The invention has the beneficial effects as follows: the present invention is simple in structure, operates also very simply, makes manufacturing cost and use cost all lower, has greatly improved work efficiency; And, to sterilising temp and the steam pressure of air filter, can control, can not cause the filter element of air filter sterilizing not thorough or excessively sterilizing; And can to air filter, adopt three kinds of different sterilization methods according to user's needs, greatly facilitate user's use.
The accompanying drawing explanation
Fig. 1 is the theory structure schematic diagram that the moist heat steam sterilization cabinets of making-up air device of the present invention is installed.
Fig. 2 is local theory structure schematic diagram in Fig. 1.
The specific embodiment
Below in conjunction with accompanying drawing, describe the specific embodiment of the invention scheme in detail.
As depicted in figs. 1 and 2, the online bactericidal unit of moist heat steam sterilization cabinets of the present invention, comprise: air filter G, respectively with the advancing of air filter G, admission line and outlet pipe that outlet is connected, admission pipeline and the drain water piping be connected with the import of air filter G, in admission line and outlet pipe, be serially connected with respectively air intake control valve ZC3 and leaving air control valve ZC2, in drain water piping, be serially connected with hydrophobic control valve ZC6 and hydrophobic filter S3, in the admission pipeline, be serially connected with inlet valve J2 and vapor filter G2, exit at the admission pipeline is divided into two-way, one tunnel is advanced pure steam valve ZC4 via filter and is connected with the outlet of air filter G, another road is connected via the outlet that inner room advances pure steam valve ZC5 and leaving air control valve ZC2, in the porch of described drain water piping, be provided with temperature probe W2 and pressure controller DB1, described air intake control valve ZC3 and leaving air control valve ZC2, hydrophobic control valve ZC6 and filter advance pure steam valve ZC4 and inner room and advance pure steam valve ZC5 and be autocontrol valve, and described inlet valve J2 is manual ball valve.
Moist heat steam sterilization cabinets of the present invention is installed can adopt three kinds of online sterilization methods to carry out sterilization to air filter G:
1, with after the sterilizing cabinet inner room communicates carry out the while sterilization method, this sterilization method is that the article in air filter G and sterile chamber carry out sterilizing simultaneously, air filter G and sterile chamber do as a whole, in sterilizing indoor sterilizing, also to air filter G, have carried out sterilizing.Shown in Figure 2, its specific works process is: before operation, each autocontrol valve all is in closed condition, setting according to program, after the sterilizing cabinet chuck reaches preheating time, vacuum pump P, leaving air control valve ZC2 and vacuum control valve ZC7 open simultaneously, sterile chamber and air filter G are carried out to evacuation to discharge the cold air in sterile chamber and air filter G, to guarantee the temperature homogeneity of sterile chamber, after evacuation reaches set point number, close vacuum pump P, vacuum control valve ZC7, start the hydrophobic control valve ZC13 in sterile chamber, inner room advances pure steam valve ZC5 and hydrophobic control valve ZC6, after temperature that the temperature probe W2 at the thermometric control head W1 at the minimum point for measuring temperature place of sterile chamber and the minimum point for measuring temperature of air filter G place records reaches the sterilising temp set, start to count sterilization time, after arriving the setting sterilization time, close the hydrophobic control valve ZC13 in sterile chamber, inner room advances pure steam valve ZC5 and hydrophobic control valve ZC6, open the steam in exhaust-control valve ZC8 discharge sterile chamber and air filter G, when Pressure Drop to setting pressure, close exhaust-control valve ZC8, and open vacuum control valve ZC7, filter element to the sterilizing article in sterile chamber and air filter G carries out vacuum drying, after reaching setting-up time, (because having negative pressure, vacuum drying sterilizing cabinet inner room exists), close vacuum control valve ZC7, and open air intake control valve ZC3, by the air filter G by sterilizing mistake, input clean atmospheric air to sterile chamber, after making pressure in sterile chamber reach the safe pressure opened the door, whole sterilizing program finishes.
2, with sterilizing cabinet, heat up simultaneously and sterilizing, this sterilization method is that air filter G can carry out simultaneously with sterilizing cabinet is sterilizing, pass through program setting, also can start air filter G evening, with guarantee sterilizing to the air of carrying in sterile chamber, be later clean, when sterilizing cabinet is sterilizing, carry out sterilizing to air filter G.Shown in Figure 2, its specific works process is: before operation, each autocontrol valve all is in closed condition, setting according to program, after the sterilizing cabinet chuck reaches preheating time, vacuum pump P, leaving air control valve ZC2 and vacuum control valve ZC7 open simultaneously, sterile chamber and air filter G are carried out to evacuation to discharge the cold air in sterile chamber and air filter G, to guarantee the temperature homogeneity of sterile chamber, after evacuation reaches set point number, close vacuum pump P, leaving air control valve ZC2 and vacuum control valve ZC7, start the hydrophobic control valve ZC13 in sterile chamber, filter advances pure steam valve ZC4, inner room advances pure steam valve ZC5 and hydrophobic control valve ZC6, after temperature that the temperature probe W2 at the thermometric control head W1 at the minimum point for measuring temperature place of sterile chamber and the minimum point for measuring temperature of air filter G place records reaches the sterilising temp set, start to count sterilization time, after reaching the setting sterilization time, close the hydrophobic control valve ZC13 in sterile chamber, inner room advances pure steam valve ZC5 and hydrophobic control valve ZC6, open the steam in exhaust-control valve ZC8 discharge sterile chamber and air filter G, when Pressure Drop to setting pressure, close exhaust-control valve ZC8, and open vacuum control valve ZC7, filter element to the sterilizing article in sterile chamber and air filter G carries out vacuum drying, after reaching setting-up time, (because having negative pressure, vacuum drying sterilizing cabinet inner room exists), close vacuum control valve ZC7, and open air intake control valve ZC3, by the air filter G by sterilizing mistake, input clean atmospheric air to sterile chamber, after making pressure in sterile chamber reach the safe pressure opened the door, whole sterilizing program finishes.
3, the independent sterilization of air filter G self, this mode are unsterilised or idle the time at inner room, carry out sterilizing online to empty filter made device G.This online sterilization method does not need to carry out simultaneously with sterile chamber is sterilizing, does not therefore just need top two kinds of modes after the chuck preheating, and inner room just starts evacuation.Shown in Figure 2, its specific works process is: before operation, each autocontrol valve all is in closed condition, setting according to program, open filter and advance pure steam valve ZC4, hydrophobic control valve ZC6, in air filter G, directly input pure steam, pass through pressure, the dual control of temperature comes the interior pressure of homeostasis air filter G and the minimum temperature of air filter G, to guarantee the uniformity of temperature, sterilising temp is laggard enters the sterilizing stage reaching, after reaching and setting sterilization time, close filter and advance pure steam valve ZC4 and hydrophobic control valve ZC6, open leaving air control valve ZC2 and vacuum control valve ZC7 carries out evacuation to air filter G, with the delay steam in deaeration filter G, after reaching setting-up time, close vacuum control valve ZC7, and open air intake control valve ZC3 and in sterile chamber, input pure air by air filter G, pressure in sterile chamber is gone up to normal pressure, get back to the front state of operation.
In sum, be equipped with moist heat steam sterilization cabinets of the present invention to the online sterilization of air filter G than pulling down, and separately air filter G to be carried out to sterilizing effect well a lot; And, saved the dismounting installation time, improved work efficiency; And prevented the secondary pollution to sterilizing article in sterile chamber.Met the requirement of national GMP authentication specifications fully.
Claims (2)
1. the online bactericidal unit of moist heat steam sterilization cabinets, comprise: air filter and respectively with the advancing of air filter, admission line and outlet pipe that outlet is connected, in admission line and outlet pipe, be serially connected with respectively air intake control valve and leaving air control valve, it is characterized in that: the drain water piping that also includes the admission pipeline and be connected with the import of air filter, in drain water piping, be serially connected with hydrophobic control valve and hydrophobic filter, in the admission pipeline, be serially connected with inlet valve and vapor filter, exit at the admission pipeline is divided into two-way, one tunnel is advanced pure steam valve via filter and is connected with the outlet of air filter, another road is connected via the outlet that inner room advances pure steam valve and leaving air control valve, in the porch of described drain water piping, be provided with temperature probe and pressure controller.
2. online bactericidal unit according to claim 1, it is characterized in that: described air intake control valve, leaving air control valve and hydrophobic control valve and filter advance pure steam valve and inner room and advance pure steam valve and be autocontrol valve, and described inlet valve is manual ball valve.
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| Application Number | Priority Date | Filing Date | Title |
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| CN2009101451604A CN101690824B (en) | 2009-10-12 | 2009-10-12 | On-line sterilizer of damp and hot vapour sterilization cabinet |
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| CN2009101451604A CN101690824B (en) | 2009-10-12 | 2009-10-12 | On-line sterilizer of damp and hot vapour sterilization cabinet |
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| CN101690824A CN101690824A (en) | 2010-04-07 |
| CN101690824B true CN101690824B (en) | 2013-11-27 |
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Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103394106B (en) * | 2013-07-30 | 2015-04-08 | 山东新华医疗器械股份有限公司 | Steam sterilizer and sterilization process |
| CN104888243A (en) * | 2015-05-15 | 2015-09-09 | 楚天科技股份有限公司 | Sterile filter online sterilization device and method |
| CN105341617A (en) * | 2015-10-08 | 2016-02-24 | 青海泰柏特生物科技有限公司 | Circulation steam sterilization method for Chinese wolfberry fruit powder |
| CN105146235A (en) * | 2015-10-08 | 2015-12-16 | 青海泰柏特生物科技有限公司 | Method for killing microorganisms on surfaces of dry wolfberry fruits through circulating water vapor |
| CN109304062A (en) * | 2017-07-26 | 2019-02-05 | 上海至纯洁净系统科技股份有限公司 | A kind of improved pipe-line system for setting air filter and its sterilizing methods |
| CN109901648B (en) * | 2017-12-11 | 2021-02-09 | 杭州科腾生物制品有限公司 | Control method of final sterilization system of gel pre-filled and sealed syringe |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN201093467Y (en) * | 2007-11-02 | 2008-07-30 | 马庆华 | Pure steam generator |
| CN201519313U (en) * | 2009-10-12 | 2010-07-07 | 张家港市华菱医疗设备制造有限公司 | On-line sterilization device for moist heat steam sterilization cabinets |
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Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN201093467Y (en) * | 2007-11-02 | 2008-07-30 | 马庆华 | Pure steam generator |
| CN201519313U (en) * | 2009-10-12 | 2010-07-07 | 张家港市华菱医疗设备制造有限公司 | On-line sterilization device for moist heat steam sterilization cabinets |
Non-Patent Citations (1)
| Title |
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| JP特开平1-70059B2 1989.05.08 |
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Address after: Suzhou City, Jiangsu province 215632 gold town Zhangjiagang city Nansha sanlijia Road, Zhangjiagang Hualing Medical Equipment Co Ltd Patentee after: Zhangjiagang Hualing Medical Equipment Co Ltd Address before: 215632, Nansha, Jiangsu Province, Zhangjiagang Town, three gold road Patentee before: Zhangjiagang Hualing Medical Equipment Manufacturing Co., Ltd. |