CN101688151A - Skin cleaner and the N-acyl glutamate that is used for this skin cleaner - Google Patents
Skin cleaner and the N-acyl glutamate that is used for this skin cleaner Download PDFInfo
- Publication number
- CN101688151A CN101688151A CN200880022504A CN200880022504A CN101688151A CN 101688151 A CN101688151 A CN 101688151A CN 200880022504 A CN200880022504 A CN 200880022504A CN 200880022504 A CN200880022504 A CN 200880022504A CN 101688151 A CN101688151 A CN 101688151A
- Authority
- CN
- China
- Prior art keywords
- acyl glutamate
- acyl
- glutaminate
- quality
- glutamate
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Images
Classifications
-
- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
- C11D1/00—Detergent compositions based essentially on surface-active compounds; Use of these compounds as a detergent
- C11D1/02—Anionic compounds
- C11D1/04—Carboxylic acids or salts thereof
- C11D1/10—Amino carboxylic acids; Imino carboxylic acids; Fatty acid condensates thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/44—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
- A61K8/442—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof substituted by amido group(s)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/10—Washing or bathing preparations
-
- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
- C11D17/00—Detergent materials or soaps characterised by their shape or physical properties
- C11D17/06—Powder; Flakes; Free-flowing mixtures; Sheets
-
- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
- C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
- C11D3/0005—Other compounding ingredients characterised by their effect
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/74—Biological properties of particular ingredients
Abstract
The invention provides the foaming property with excellence, smooth feeling and the N-acyl glutamate of moist feeling and the skin cleaner that contains this N-acyl glutamate after the cleaning.This N-acyl glutamate and use the skin cleaner of this N-acyl glutamate to be characterised in that: the N-lauroyl glutamate salt that contains 35～50 quality %; and the total amount of N-palmitoyl glutaminate and N-stearyl-glutaminate is 30～50 quality %, also contains the N-oleoyl glutaminate of 14～25 quality %.
Description
Technical field
The present invention relates to the invention of N-acyl glutamate, especially relates to the N-acyl glutamate of the lipid acid composition of having adjusted the N-acyl glutamate and the skin cleaner that uses this N-acyl glutamate.
Background technology
For the skin cleaner that wash one's face agent and health are used etc., when expecting to have high security, good foaming property and good washing and the usability after the towel.Usability is meant that well when washing bubble eliminates soon, and no grating has slick sense of touch, and towel off dried after, skin is moist, no distending pain has moist feeling.
The N-acyl glutamate is known to be low irritant, safe, the good sanitising agent (patent documentation 1) of sense of touch after foaming property, the use.Developed the sanitising agent (patent documentation 2, patent documentation 3, patent documentation 4) of many use N-acyl glutamates.Yet, the lipid acid of adjusting the N-acyl glutamate form with improve the N-acyl glutamate as the function aspects of sanitising agent without any research.Open in the patent documentation 5, compare foul smell still less with the N-acyl glutamate of the lipid acid acidylate in vegetables oil source with N-acyl glutamate with the lipid acid acidylate in animal oil source.Though disclose the lipid acid composition, do not expressed the function difference of forming the different N-acyl glutamates that cause owing to lipid acid.
When the chain length of the acyl group of N-acyl glutamate was longer, water-soluble reduction was difficult to cooperate with liquid cleaner.Yet, can cooperate with solid state or pulverous sanitising agent by the N-acyl glutamate that the chain length of acyl group is long, and can bring into play its functions peculiar.The N-acyl glutamate that the chain length of acyl group is long has the smooth feeling (the smooth sensation of skin after the washing and finger) after the excellent cleaning, and this use sense of touch can not realize with other tensio-active agents.Yet the N-acyl glutamate that the chain length of acyl group is long has the shortcoming of foaming property difference.On the other hand, though the short N-acyl glutamate of the chain length of acyl group has good foaming property, the smooth feeling after cleaning, the sense of preserving moisture are inferior.Even these multiple N-acyl glutamates are mixed, all excellent sanitising agent of smooth feeling, moist feeling (sense of preserving moisture) and foaming property after also not obtaining so far to clean.
Patent documentation 1: Japanese kokai publication hei 6-158089 communique
Patent documentation 2: Japanese kokai publication hei 6-157292 communique
Patent documentation 3: TOHKEMY 2005-60298 communique
Patent documentation 4: TOHKEMY 2005-298455 communique
Patent documentation 5: TOHKEMY 2003-34670 communique
Summary of the invention
The problem that invention will solve
Contain more acyl group chain length the solid soap of long N-acyl glutamate be known with N-acyl glutamic acid sodium, when washing one's face, the smooth feeling after the cleaning, preserve moisture that to feel be excellent with this sanitising agent.Yet, have the poor slightly shortcoming of foaming property.In order to improve foaming property when this solid soap cooperates the N-lauroyl glutamate salt of foaming property excellence in N-acyl glutamic acid sodium, have the smooth feeling after infringement is cleaned, the problem of the sense of preserving moisture.Therefore, problem of the present invention is the N-acyl glutamate that the modulation special fatty acid is formed, and provides foaming property, the N-acyl glutamate that the smooth feeling after cleaning and moist feeling are all excellent and the skin cleaner that contains this N-acyl glutamate.
The scheme that is used to deal with problems
Major programme of the present invention is as described below.
(1) a kind of N-acyl glutamate; it is characterized in that; the N-lauroyl glutamate salt that contains 35～50 quality %, and the total amount of N-palmitoyl glutaminate and N-stearyl-glutaminate is 30～50 quality %, also contains the N-oleoyl glutaminate of 14～25 quality %.
(2) according to above-mentioned (1) described N-acyl glutamate, it will be by will mixed uniformly N-acyl glutamate drying obtaining under solution state.
(3) according to above-mentioned (1) or (2) described N-acyl glutamate, it is Powdered or particulate state.
(4) a kind of skin cleaner is characterized in that, contains each above-mentioned (1)～(3) described N-acyl glutamate.
(5) a kind of Powdered or granular skin cleaner is characterized in that, contains each above-mentioned (1)～(3) described N-acyl glutamate.
The effect of invention
According to the present invention, the smooth feeling that has after good foaming property and excellent skin clean and the N-acyl glutamate as the sanitising agent raw material of moist feeling (sense of preserving moisture) can be provided, the sanitising agent of the excellence of having utilized this N-acyl glutamate can be provided in addition.
Description of drawings
Fig. 1 is the NMF dissolution test result's of each sanitising agent of signal figure.
Fig. 2 is the figure of the cuticlar water component of each sanitising agent of signal.
Fig. 3 is the figure of the foaming property test-results of each sanitising agent of signal.
Embodiment
Use the N-acyl glutamate of the N-lauroyl glutamate salt that contains 35～50 quality % among the present invention.When the content of N-lauroyl glutamate salt is lower than 35 quality %, can not obtain foaming property (lathering power) fully, when surpassing 50 quality %, smooth feeling after the cleaning and moist feeling reduce.
Foaming property described in the present invention, moist feeling and smooth feeling for example can be estimated by test example described later.How many foaming property can be estimated by the foam volume that foams, and for example can measure with the lathering power form.Moist feeling also can be described as the sense of preserving moisture, and can wait and estimate by the be adjacent to sensation, NMF dissolution test, mensuration cuticlar water component that wipes out skin and palm behind the moisture after cleaning.Smooth feeling can be estimated by the skin after cleaning and the smooth sensation of finger.
In addition, N-acyl glutamate of the present invention contains N-palmitoyl glutaminate and the N-stearyl-glutaminate that amounts to 30～50 quality %, contains the N-oleoyl glutaminate of 14～25 quality %.When the total content of N-palmitoyl glutaminate and N-stearyl-glutaminate is lower than 30 quality %, smooth feeling, moist feeling variation, and when surpassing 50 quality %, be difficult to obtain foaming property fully.When the content of N-oleoyl glutaminate is lower than 14 quality %, a certain variation of smooth feeling, moist feeling and foaming property, perhaps smooth feeling, moist feeling and foaming property all worsen.When the content of N-oleoyl glutaminate surpasses 25 quality %, powder through the time fuse, be difficult to keep pulverulence.The lipid acid of N-acyl glutamate is formed as long as in above-mentioned scope; wherein; especially the concentration of N-lauroyl glutamate salt is that the total concn of 36～41 quality %, N-palmitoyl glutaminate and N-stearyl-glutaminate is when being 38～46 quality %; because foaming property excellence is more preferably as sanitising agent.
N-acyl glutamate of the present invention can obtain by known method, for example can obtain by the reaction of lipid acid acyl chlorides and L-glutamic acid.Acyl group is by the saturated of carbonatoms 8～22 or unsaturated fatty acids deutero-acyl group; for example can be the acyl group from the mixture of the lipid acid of single compositions such as lauric acid, tetradecanoic acid, palmitinic acid, stearic acid, oleic acid, mountain Yu acid, can be from the refining thing of the mixed fatty acid of natural acquisitions such as palm oil fatty acid, coco-nut oil fatty acid, sunflower oil lipid acid, soya fatty acid, tallow fatty acids, sclerosis tallow fatty acids or from the acyl group by the synthetic fatty acid mixt that obtains in addition.
Powdered or granular N-acyl glutamate of the present invention; can be by preparing different various powders shape of lipid acid composition or granular N-acyl glutamate and making it contain the N-lauroyl glutamate salt of 35～50 quality % their mixing; the N-oleoyl glutaminate of the mixture of the N-palmitoyl glutaminate of 30～50 quality % and N-stearyl-glutaminate and 14～25 quality %; but in order to improve foaming property; preferably; N-acyl glutamate homogenizing under solution state of above-mentioned composition is dried again, is processed into for example Powdered or particulate state.
As with the N-lauroyl glutamate salt that contains 35～50 quality % of the present invention; N-acyl glutamate homogenizing under solution state of the N-oleoyl glutaminate of the mixture of the N-palmitoyl glutaminate of 30～50 quality % and N-stearyl-glutaminate and 14～25 quality % is processed into Powdered or granular method again; for example; can enumerate sends as an envoy to contains the lauric acid of appropriate amount; palmitinic acid; the carboxylic acid halides of stearic acid and oleic fatty acid mixt and L-glutamic acid reaction; with the neutralization of gained N-acyl glutamic acid, powdered or granular method again.As with the N-lauroyl glutamate salt that contains 35～50 quality % of the present invention; the N-acyl glutamate of the N-oleoyl glutaminate of the mixture of the N-palmitoyl glutaminate of 30～50 quality % and N-stearyl-glutaminate and 14～25 quality % is homogenizing and the method that is dried under solution state; can list N-lauroyl glutamate salt with 35～50 quality %; the N-oleoyl glutaminate of the mixture of the N-palmitoyl glutaminate of 30～50 quality % and N-stearyl-glutaminate and 14～25 quality % mixes and is dissolved in the solvent and homogenizing makes it the exsiccant method then.As solvent, for example can list hot water etc.
Preferably, lauric acid mainly is made of the refining thing of coco-nut oil fatty acid, and stearic acid mainly is made of the refining thing of palm oil fatty acid, and oleic acid mainly is made of the refining thing of sunflower oil lipid acid.Especially, for oleic acid, tallow fatty acids, palm oil fatty acid, soya fatty acid make with extra care and are compared during the material that obtains with using, the words of the refining thing of use sunflower oil lipid acid can lower foul smell.
The N-acyl glutamic acid is preferably made organic salt forms such as metal-salts such as sodium, potassium, trolamine and is used.
In the scope of not damaging effect of the present invention, can cooperate the tensio-active agent beyond the N-acyl glutamate in the Powdered or particulate state skin cleaner of the present invention.Tensio-active agent can be the material that anion surfactant, cats product, amphoterics, nonionogenic tenside etc. have the surfactivity effect, can be any in crude substance or the synthetic.As the representative example of anion surfactant, can list soap, acyl isethinate, acylaspartic acid salt etc.
In skin cleaner of the present invention, can contain carbohydrate, glycitols, organic powder, inorganic powder, high score subclass, sanitas, sequestrant, UV light absorber, ultraviolet screening agent (ultraviolet screener), wetting Agent for Printing Inks, spices, pH regulator agent, siccative etc.Vitamins, skin active agent, blood circulation accelerant be can also contain, often other effective components, physiologically active ingredients such as bacterium (resident skin flora) control agent, active oxygen eliminating agent, anti-inflammatory agent, whitening agent, sterilant occupied.
As carbohydrate, glycitols, can list glucose, Sorbitol Powder, seminose, N.F,USP MANNITOL, semi-lactosi, melampyrum, maltose, maltose alcohol, trehalose, erythrose, tetrahydroxybutane, wood sugar, Xylitol, sucrose, lactose, Saccharum lactis, DIFRUCTOSE ANTHYDRIDE etc.
As organic powder, can list polyethylene powders, polystyrene powder, polymethylmethacrylate powder, nylon powder, polyurethane powder, agar powder, cork (cork) powder, starch etc.
As inorganic powder, can list talcum, kaolin, silica, mica, zeolite, wilkinite, titanium dioxide etc.
As the high score subclass, can list Sudan Gum-arabic, tragacanth (Tragacanth Gum), Polygalactan, guar gum, carrageenin, pectin, xanthan gum, Wen Quince seed glue, dextran, cationization dextran, pulullan polysaccharide, carboxymethyl starch, collagen, casein, gelatin, methylcellulose gum, methylhydroxypropylcellulose, Natvosol, Xylo-Mucine (CMC), Vltra tears, sodium alginate, carboxyvinyl polymer (CARBOPOL etc.) etc.
As sanitas, can list for example methyl p-hydroxybenzoate, ethyl p-hydroxybenzoate etc.
As sequestrant, for example can list edetates such as disodium ethylene diamine tetraacetate, ethylenediamine tetraacetic acid (EDTA), disodium edta.
As effective component, can list the L-xitix, the L-ascorbic acid phosphoric acid esters, L-xitix monopalmitate, the L-Vitamin C dipalmitate, L-xitix-vitamin c class such as 2-glucoside etc., gsh, whitening agents such as Herba Saxifragae extract, royal jelly, skin active agents such as beech tree extract, capsaicine, zingiberone, cantharides tincture (Cantharides tincture), isarol, caffeine, Weibull, blood circulation accelerants such as gamma oryzanol, glycyrrhizin derivative, the glycyrrhetinic acid derivative, antiphlogistics such as azulene, arginine, Serine, leucine, amino acidses such as tryptophane, often occupy the maltose-sucrose condenses in the bacterium control agent, Toyolysom DS etc.
Embodiment
(preparation of N-acyl glutamate)
Make the acyl chlorides that the mixture be made up of various lipid acid forms and the glutaminate reaction of reacting weight, carry out neutralization reaction, homogenizing under solution state is dried then, the Powdered acyl glutamic acid sodium salt of the various compositions of preparation table 1.The various acyl glutamic acid sodium salts of gained are used for following test as sanitising agent.
Table 1
The usability evaluation test of (test example 1) sanitising agent
Get the N-acyl glutamic acid sodium salt formed shown in the above-mentioned table 1 of 0.5g on palm; add the water of about 10 times of weight of N-acyl glutamate powder; it is foamed, wash one's face, by 5 grades of foaming property of judgement criteria evaluation, smooth feeling and moist feelings with the common method of washing one's face.The experimenter is 10 professional judging panels.Standard is as follows: use solid soap that comparative example 1 forms with N-acyl glutamic acid sodium (being designated hereinafter simply as comparative example 1 composition), and will be to its evaluation as 3 in 5 grades of evaluations.
Estimate according to following judgement criteria.The result is shown in the table 1.
(1) foaming property: estimate according to the foam volume that foams (many 5 → few 1), therefore comparative example 1 composition is decided to be " △: foaming property is inferior " with " 3 minutes " in the standard because foaming property is poor slightly, and following standard is set.
4.5 divide above to ◎ below 5 minutes: foaming property is very excellent.
3.5 divide above to less than 4.5 minutes zero: foaming property excellence.
2.5 divide above to less than 3.5 fens △: foaming property is inferior.
Less than 2.5 minutes *: foaming property is very inferior.
(2) smooth feeling: the smooth sensation (smooth 5 → rough 1) by skin after the washing and finger is estimated.Because comparative example 1 composition has excellent smooth feeling, therefore " 3 minutes " in the standard are decided to be " zero: the smooth feeling excellence ", following standard is set.
3.5 divide above arriving less than 5 fens ◎: smooth feeling is very excellent.
2.5 divide above arriving: the smooth feeling excellence less than 3.5 minutes zero.
1.5 divide above arriving less than 2.5 fens △: smooth feeling is inferior.
Less than 1.5 minutes *: smooth feeling is very inferior.
(3) moist feeling: be adjacent to sensation (moistening 5 → dry and comfortable 1) evaluation by what wipe skin behind the moisture and palm.Because comparative example 1 composition has excellent moist feeling, therefore " 3 minutes " in the standard are decided to be " zero: the moist feeling excellence ", following standard is set.
3.5 divide above arriving less than 5 fens ◎: moist feeling is very excellent.
2.5 divide above arriving: the moist feeling excellence less than 3.5 minutes zero.
1.5 divide above arriving less than 2.5 fens △: moist feeling is inferior.
Less than 1.5 minutes *: moist feeling is very inferior.
The figure of merit of N-acyl glutamic acid sodium (being designated hereinafter simply as embodiment 1 composition) with the sodium lauroyl glutamate (being designated hereinafter simply as comparative example 2 compositions) of comparative example 2 of embodiment 1 composition has been shown in table 2 and the table 3.Method of inspection uses the Wilcoxon signed rank test method.In addition, use comparative example 1 composition as standard.
Table 2
The evaluation of embodiment 1 composition
| Foaming property | Smooth feeling | Moist feeling | |
| Mean value | ?4.7 | ??3.4 | ??3.2 |
| The significance of difference | 1% time significance is arranged | Do not have | Do not have |
| Estimate | ?◎ | ??○ | ??○ |
| Standard | ?3 | ??3 | ??3 |
Embodiment 1 composition has also significantly improved foaming property in the smooth feeling and moist feeling kept with as the comparative example 1 composition equal extent of standard.
Table 3
The evaluation of comparative example 2 compositions
| Foaming property | Smooth feeling | Moist feeling | |
| Mean value | ?4.8 | ?1.0 | ?1.2 |
| The significance of difference | 1% time significance is arranged | 1% time significance is arranged | 1% time significance is arranged |
| Estimate | ?◎ | ?× | ?× |
| Standard | ?3 | ?3 | ?3 |
Comparative example 2 compositions are compared with comparative example 1 composition as standard, though foaming property is significantly excellent, and smooth feeling and moist feeling significance difference.
The usability evaluation test of (test example 2) clean flour (cleansing powder)
To being combined with clean flour and the clean flour that is combined with embodiment 1 composition, the comparison of foaming property, smooth feeling and moist feeling, evaluation as comparative example 1 composition of standard.
As standard, be decided to be " 3 minutes " with the clean flour that is combined with comparative example 1 composition, according to estimating with the same judgement criteria of test example 1.
The composition of each clean flour has been shown in the table 4, figure of merit has been shown in the table 5.Prepare clean flour by mixing each moiety (powder).
Table 4
| Composition | Be combined with the clean flour of comparative example 1 composition | Be combined with the clean flour of embodiment 1 composition |
| Comparative example 1 composition | ?40 | ?- |
| Embodiment 1 composition | ?- | ?40 |
| N.F,USP MANNITOL | ?30 | ?30 |
| Glucose | ?10 | ?10 |
| Talcum | ?20 | ?20 |
Table 5
Be combined with the evaluation of the clean flour of embodiment 1 composition
| Foaming property | Smooth feeling | Moist feeling | |
| Mean value | ?4.5 | ??3.0 | ??3.4 |
| The significance of difference | 1% time significance is arranged | Do not have | Do not have |
| Estimate | ?◎ | ??○ | ??○ |
| Standard | ?3 | ??3 | ??3 |
The clean flour that is combined with embodiment 1 composition has been kept and the smooth feeling and the moist feeling that are combined with as the clean flour equal extent of comparative example 1 composition of standard, has significantly improved foaming property simultaneously.
(test example 2) NMF dissolution test
, as index components, measure as sample with the sanitising agent shown in the table 6 with representational urocanic acid, pyrrolidone carboxylic acid (PCA) and three kinds of compositions of lactic acid in the NMF composition by clean the amount of these index components of removing with sample constituents.Mensuration is carried out 6 people according to following steps, and its mean value is shown in table 6 and Fig. 1.
(i) place cup in experimenter's forearm inside portion.
(ii) in cup, put into the 2mL sample, cover.
The arm that (iii) is placed with cup is placed on the vibrator, and keeps solution not spill.
(iv) under this state, vibrate 10 minutes, extract NMF.
(v) after this, take out the interior solution of cup, put into the 2mL pipe with dropper.
(vi) filter this solution with 0.45 μ m membrane filter, quantitative with high performance liquid chromatography.
(vii) respectively get sample solution and the standardized solution of 20 μ L,, use calibration curve method from gained calculated by peak area amount separately according to following condition high effective liquid chromatography for measuring.
High performance liquid chromatography (HPLC) analysis condition
Post: TSK-GEL ODS-80Ts 4.6mm
* 150mm
Detector: photodiode array UV210nm
Elutriant: 0.5M sodium sulfate, 0.1M phosphate aqueous solution
Flow velocity: 0.4mL/min
Injection rate: 20 μ l
Table 6
| Sanitising agent | Urocanic acid | ??PCA | Lactic acid | Amount to |
| Embodiment 1 composition | ??0.66 | ??15.87 | ??59.84 | ??76.37 |
| Comparative example 2 compositions | ??0.94 | ??20.16 | ??78.70 | ??99.80 |
| Comparative example 1 composition | ??1.53 | ??20.85 | ??75.11 | ??97.49 |
| Sodium laurate | ??1.32 | ??23.92 | ??84.96 | ??110.20 |
| Sodium Lauryl Sulphate BP/USP | ??2.17 | ??26.65 | ??99.65 | ??128.47 |
| Purified water | ??0.39 | ??6.66 | ??60.45 | ??67.50 |
(unit: ppm)
Can learn quantitatively that from table 6 when using embodiment 1 composition as sanitising agent, the total amount of required urocanic acid, PCA and lactic acid is lacked than other sanitising agents on the skin, according to this sanitising agent, even after cleaning, the NMF composition of skin is also residual, kept humidity-holding effect, moist feeling is excellent.
(test example 3) cuticlar water component
With the sanitising agent of table 7 as sample, according to following steps, measure clean before, clean after 5 minutes, the cuticlar water component after 10 minutes, after 15 minutes.Mensuration is carried out 5 times 1 people according to following steps, and mean value is shown in table 7 and Fig. 2.In addition, cleaning preceding cuticlar water component is 100%.
(i) the 0.5g sample is fully foamed.
(ii) use the foam of step (i) to clean the forearm inside portion.
After (iii) cleaning, washed for 30 seconds with flowing water.
(iv) after the washing, towel off and wipe away moisture.
(v) after this, under the thermostatic chamber of 23 ℃ of room temperatures, humidity 40%, leave standstill.
(vi) under static condition, after the process certain hour, measure 5 amounts of moisture, averaged with SKICON-200EX (I.B.S.CO., LTD. makes).
Table 7
Can learn quantitatively that from table 7 when using embodiment 1 composition as sanitising agent, cuticlar water component and comparative example 1 composition after the cleaning are roughly the same, than other sanitising agent moisture retention (moist feeling) excellences.
(test example 4) foaming property test
As sample,, measure lathering power with the sanitising agent of table 8 by paddling process repeatedly according to following steps.The result is shown in table 8 and Fig. 3.
(i) solution of preparation sample 0.5% concentration is heated to 40 ℃.
(ii) after the heating,, the mode of not foaming has in the graduated 1L tall form beaker so that being injected into solution.
(iii) the 1L tall form beaker is installed in the counter-rotating whipping appts (PROMIXPR-1200, bavin field instruments for scientific research industry (strain) company makes), stirs, foam.(20 seconds of 20 seconds of right rotation+anticlockwise+right rotation 20 seconds)
After (iv) foaming 1 minute, read foam volume.(data are the mean value of N=3)
Table 8
| Detergent composition | Lathering power (ml) |
| Comparative example 1 composition | ??300 |
| Embodiment 1 composition | ??360 |
| To under pulverulence, mix with the N-acyl glutamic acid sodium of single fat acylating acid and obtain form identical composition with embodiment 1 | ??310 |
(test example 5) forms different various evaluations based on lipid acid
In order to form different and performance difference that cause based on lipid acid, carry out the usability evaluation test same respectively and same foaming property test with testing example 4 with testing example 1 to all sanitising agent investigation that constitute by each acyl glutamate of forming in the table 1.The result is shown in the table 1.
(test example 6) estimation of stability
For each acyl glutamate of forming of table 1, observe 40 ℃ of keepings after 1 month powder whether fixed.According to following standard evaluation stability.The result is shown in the table 1.
Zero: powder does not produce fixed.
*: powder is fixed, can not be used as Powdered or granular skin cleaner.
Utilizability on the industry
According to the present invention, can provide that foaming property is good, smooth feeling and the excellent cleaning agent of moist feeling (moisturizing sense) behind the Irrigation.
Claims (5)
1. N-acyl glutamate; it is characterized in that; the N-lauroyl glutamate salt that contains 35～50 quality %, and the total amount of N-palmitoyl glutaminate and N-stearyl-glutaminate is 30～50 quality %, also contains the N-oleoyl glutaminate of 14～25 quality %.
2. N-acyl glutamate according to claim 1, it will be by will mixed uniformly N-acyl glutamate drying obtaining under solution state.
3. N-acyl glutamate according to claim 1 and 2, it is Powdered or particulate state.
4. a skin cleaner is characterized in that, contains each described N-acyl glutamate of claim 1～3.
5. a Powdered or granular skin cleaner is characterized in that, contains each described N-acyl glutamate of claim 1～3.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP219864/2007 | 2007-08-27 | ||
| JP2007219864A JP4257442B2 (en) | 2007-08-27 | 2007-08-27 | Skin cleansing agent and N-acyl glutamate used therefor |
| PCT/JP2008/061875 WO2009028259A1 (en) | 2007-08-27 | 2008-07-01 | Skin cleanser, and n-acyl glutamic acid salt for use in the same |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN101688151A true CN101688151A (en) | 2010-03-31 |
Family
ID=40386988
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN200880022504A Pending CN101688151A (en) | 2007-08-27 | 2008-07-01 | Skin cleaner and the N-acyl glutamate that is used for this skin cleaner |
Country Status (4)
| Country | Link |
|---|---|
| JP (1) | JP4257442B2 (en) |
| KR (1) | KR20100045950A (en) |
| CN (1) | CN101688151A (en) |
| WO (1) | WO2009028259A1 (en) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103784329A (en) * | 2012-10-30 | 2014-05-14 | 株式会社芳珂 | Powder skin cleanser |
| CN107184407A (en) * | 2017-05-24 | 2017-09-22 | 昆明贝泰妮生物科技有限公司 | A kind of soft and smooth moisturizing granulates clean face powder and preparation method thereof |
| CN111263803A (en) * | 2017-11-06 | 2020-06-09 | 味之素株式会社 | Cleaning agent composition |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103435509B (en) * | 2013-08-21 | 2016-03-16 | 南京华狮化工有限公司 | The preparation method of a kind of N-acyl acidic amino acid or its salt and application thereof |
| JP2017137273A (en) * | 2016-02-05 | 2017-08-10 | 株式会社ファンケル | Powdery or granular skin cleansing agent |
| CN106591011B (en) * | 2016-10-21 | 2018-03-27 | 威莱(广州)日用品有限公司 | A kind of antibacterial soap and preparation method thereof |
| JP6940328B2 (en) * | 2017-08-21 | 2021-09-29 | 株式会社ファンケル | Liquid cleaning composition |
| EP4043098A4 (en) | 2019-10-10 | 2024-01-03 | Ajinomoto Kk | Surfactant and composition |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS61271398A (en) * | 1985-05-24 | 1986-12-01 | 川研ファインケミカル株式会社 | Improved herb compounded solid detergent |
| JP3238204B2 (en) * | 1992-08-06 | 2001-12-10 | 川研ファインケミカル株式会社 | Improved solid detergent |
| JPH09125100A (en) * | 1995-11-02 | 1997-05-13 | Ajinomoto Co Inc | Transparent solid detergent |
| JPH11131099A (en) * | 1997-08-29 | 1999-05-18 | Kawaken Fine Chem Co Ltd | Composition used for transparent solid washing agent suitable for frame molding method |
| JPH11323379A (en) * | 1998-05-12 | 1999-11-26 | Ajinomoto Co Inc | Solid detergent composition |
| JP2001199876A (en) * | 2000-01-21 | 2001-07-24 | Shiseido Co Ltd | Skin detergent |
| JP2003034670A (en) * | 2001-05-17 | 2003-02-07 | Asahi Kasei Corp | Vegetable acylamino acid or salt thereof |
| JP2003096489A (en) * | 2001-09-25 | 2003-04-03 | Tsumura & Co | Solid soap |
| JP2003306696A (en) * | 2002-02-15 | 2003-10-31 | Ajinomoto Co Inc | Surfactant |
| JP4600030B2 (en) * | 2003-12-19 | 2010-12-15 | 味の素株式会社 | Crystal of N-long chain acyl glutamic acid and / or salt thereof |
-
2007
- 2007-08-27 JP JP2007219864A patent/JP4257442B2/en active Active
-
2008
- 2008-07-01 KR KR1020097022117A patent/KR20100045950A/en not_active Application Discontinuation
- 2008-07-01 WO PCT/JP2008/061875 patent/WO2009028259A1/en active Application Filing
- 2008-07-01 CN CN200880022504A patent/CN101688151A/en active Pending
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103784329A (en) * | 2012-10-30 | 2014-05-14 | 株式会社芳珂 | Powder skin cleanser |
| CN107184407A (en) * | 2017-05-24 | 2017-09-22 | 昆明贝泰妮生物科技有限公司 | A kind of soft and smooth moisturizing granulates clean face powder and preparation method thereof |
| CN111263803A (en) * | 2017-11-06 | 2020-06-09 | 味之素株式会社 | Cleaning agent composition |
Also Published As
| Publication number | Publication date |
|---|---|
| KR20100045950A (en) | 2010-05-04 |
| JP2009051945A (en) | 2009-03-12 |
| WO2009028259A1 (en) | 2009-03-05 |
| JP4257442B2 (en) | 2009-04-22 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN101688151A (en) | Skin cleaner and the N-acyl glutamate that is used for this skin cleaner | |
| CN111631974B (en) | Soap ammonia type face cleaning product and preparation method thereof | |
| Bouassida et al. | Potential application of Bacillus subtilis SPB1 lipopeptides in toothpaste formulation | |
| JP4966862B2 (en) | Process for preparing hydrocolloids | |
| WO2013131307A1 (en) | Transparent beauty soap composition | |
| CN109401869B (en) | Liquid skin cleaning composition and preparation method and application thereof | |
| WO2004113390A1 (en) | Galactomannan hydrocolloids | |
| CN103119144B (en) | Antibacterial cleaning composition | |
| JPH08199188A (en) | Raw solution for forming foam | |
| CN109288725A (en) | A kind of transparent amino acid pattern is without silicone oil shampoo | |
| JP2981975B2 (en) | Cosmetic composition | |
| CN104546610A (en) | Anti-aging facial cleanser and preparation method thereof | |
| JP2008179586A (en) | Creamy skin detergent composition | |
| US20220323306A1 (en) | Free-flowing powder form conditioner | |
| DE102010055252A1 (en) | Process for the development of a liquid composition to be applied as a foam to the skin and a topically applicable composition | |
| CN106366207A (en) | Fenugreek water-soluble polysaccharide hand sanitizer and preparation method thereof | |
| CN107287059B (en) | Baby's children's clothes object bio-enzyme cleaning agent | |
| CN108836885A (en) | A kind of amino acid and the two-in-one mildy wash of soap base and its preparation process and application | |
| CN103784329A (en) | Powder skin cleanser | |
| CN106491391B (en) | A kind of high viscosity clear transdermal cleaning gel and its preparation method and application | |
| JPH03232811A (en) | Cosmetic | |
| TWI301836B (en) | Crystalline α-d-glucosyl α-d-galactoside, saccharide composition comprising the same, process for producing the same, and uses thereof | |
| JP6759395B2 (en) | Powdered skin cleanser | |
| JPH08169816A (en) | Hydrolyzed wheat protein | |
| JP2020059834A (en) | Thickener |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| REG | Reference to a national code |
Ref country code: HK Ref legal event code: DE Ref document number: 1139173 Country of ref document: HK |
|
| C12 | Rejection of a patent application after its publication | ||
| RJ01 | Rejection of invention patent application after publication |
Open date: 20100331 |
|
| REG | Reference to a national code |
Ref country code: HK Ref legal event code: WD Ref document number: 1139173 Country of ref document: HK |