CN101687883B - 囊性纤维化跨膜传导调节因子的调节剂 - Google Patents

囊性纤维化跨膜传导调节因子的调节剂 Download PDF

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CN101687883B
CN101687883B CN200880022842XA CN200880022842A CN101687883B CN 101687883 B CN101687883 B CN 101687883B CN 200880022842X A CN200880022842X A CN 200880022842XA CN 200880022842 A CN200880022842 A CN 200880022842A CN 101687883 B CN101687883 B CN 101687883B
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compound
formula
ring
disease
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CN101687883A (zh
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H·宾奇
P·格鲁藤休伊斯
S·哈迪达鲁阿
周竞兰
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Vertex Pharmaceuticals Inc
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    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4365—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system having sulfur as a ring hetero atom, e.g. ticlopidine
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    • A61P5/14—Drugs for disorders of the endocrine system of the thyroid hormones, e.g. T3, T4
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    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents

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  • Physical Education & Sports Medicine (AREA)
  • Emergency Medicine (AREA)
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  • Hospice & Palliative Care (AREA)
  • Urology & Nephrology (AREA)
  • Immunology (AREA)
  • Pulmonology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CN200880022842XA 2007-05-25 2008-05-23 囊性纤维化跨膜传导调节因子的调节剂 Expired - Fee Related CN101687883B (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US93177507P 2007-05-25 2007-05-25
US60/931,775 2007-05-25
US96870407P 2007-08-29 2007-08-29
US60/968,704 2007-08-29
PCT/US2008/064646 WO2008147952A1 (en) 2007-05-25 2008-05-23 Modulators of cystic fibrosis transmembrane conductance regulator

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CN101687883A CN101687883A (zh) 2010-03-31
CN101687883B true CN101687883B (zh) 2012-05-23

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CN200880022842XA Expired - Fee Related CN101687883B (zh) 2007-05-25 2008-05-23 囊性纤维化跨膜传导调节因子的调节剂

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US (3) US8399479B2 (https=)
EP (1) EP2170901B1 (https=)
JP (1) JP5686596B2 (https=)
CN (1) CN101687883B (https=)
AU (1) AU2008256717B2 (https=)
CA (1) CA2688004C (https=)
ES (1) ES2548292T3 (https=)
HU (1) HUE025553T2 (https=)
NZ (1) NZ581419A (https=)
WO (1) WO2008147952A1 (https=)

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CN101687883A (zh) 2010-03-31
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CA2688004A1 (en) 2008-12-04
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