CN101683374A - Patch for treating disc herniation and method for producing the same - Google Patents
Patch for treating disc herniation and method for producing the same Download PDFInfo
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- CN101683374A CN101683374A CN200810151815A CN200810151815A CN101683374A CN 101683374 A CN101683374 A CN 101683374A CN 200810151815 A CN200810151815 A CN 200810151815A CN 200810151815 A CN200810151815 A CN 200810151815A CN 101683374 A CN101683374 A CN 101683374A
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- pheretima
- clear paste
- dressing
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Abstract
The invention provides a patch for treating disc herniation and a method for producing the same. The invention contains the following components in proportion by weight: Eucommia ulmoides Oliv. 5-10,Dipsacus asperoides 3-10, lumbricus 3-10; the invention includes the steps of: proportionally mixing raw materials, grinding until particle diameter of each component is 100-200 mu m; using CO2 supercritical extraction, fractionating acquired distillates with a fractionating tower, mixing each component in the formula into nano medicinal pulp according to the formula proportionality through the nano dispersing apparatus, adding accelerating agent for percutaneous absorption and contact adhesive into the circular type low temperation drying coater, and after coating, executing shearing, qualitytest, packaging and then sending the product into warehouse. The invention uses a scientific method for processing and extracting medicinal materials, which are filled in the framework of the substrate, and the paster substrate has a good compatibility with skin, and is good for medicament molecule to pass; the medicament has the advantages of slow release, smooth and steady administration, smallirritation, without toxic and side effects, thereby preventing toxic and side effects for human body brought by oral medication and injection.
Description
Technical field
The present invention is a Chinese herbs paste, relates in particular to a kind of patch and manufacture method for the treatment of intervertebral disk hernia.
Background technology
The reason of intervertebral disc disorder, the one, congestion retardance due to wound is strained; The 2nd, the miopragia of protection intervertebral disc due to the ligament calcification; The 3rd, the vertebra fibrous ring is broken due to the biological long-term extruding of hyperostosis, the friction intervertebral disc, the 4th, suffer from a deficiency of the kidney to intervertebral disc lose its replenishing vital QI with drugs of warm nature make moist due to the intervertebral disc atrophy.More than all because of forcing vertebra annulus fibrosus breaks, vertebra swelling of nucleus to cause intervertebral disk hernia, deviate from or bulge.After general patient is ill, adopt medicament to treat usually, mostly be oral drugs or injection, but the equal toxic side effect of oral drugs and injection, can produce through liver first-pass effect and gastrally release light reaction, so just bring safety problem to the patient.
Summary of the invention
Main purpose of the present invention is to solve oral drugs and injection to the toxic and side effects that human body brings, and provides a kind of toxic and side effects of having avoided oral administration to use, also without liver first-pass effect and gastral patch and the manufacture method of releasing light treatment intervertebral disk hernia.
The technical solution adopted for the present invention to solve the technical problems is:
Form by following weight proportion component: Cortex Eucommiae 5-10 part, Radix Dipsaci 3-10 part, Pheretima 3-10 part.Cortex Eucommiae improving inspiration by invigorating the kidney Zhi Qiben, medicinal powder for relieving pain is cold, resolving blood stasis and dredging collateral is controlled its mark, and continuous muscle T-Ring removes its root.
The patch of treatment intervertebral disk hernia and the crude drug that manufacture method is following column weight amount proportioning part are made according to following method: Cortex Eucommiae 5-10 part, Radix Dipsaci 3-10 part, Pheretima 3-10 part.
Respectively the Cortex Eucommiae, Radix Dipsaci and Pheretima powder are broken into coarse powder, decoct with water 1-3 time respectively then, each 1-3 hour, collecting decoction filtered, and surveying relative density when filtrate is concentrated into 80 ℃ is the clear paste of 1.00-1.20.
Merge above-mentioned clear paste, surveying relative density when continuing to be concentrated into 80 ℃ is the clear paste of 1.10-1.30, adds dressing then; Dressing is: 60 parts of polyvinyl alcohol, 120 parts in gelatin, 60 parts of sodium carboxymethyl cellulose, 480 parts of glycerol and an amount of distilled water, add mix homogeneously, and be prepared into cloth cream.
Cloth cream is coated on cloth or non-woven fabrics or the polyethylene sheets, and the low humidity drying is pasted on the ventilative adhesive plaster, and the lid lining is cut into pieces, quality inspection, packing warehouse-in.
Dressing is Kaolin, bentonite, zinc oxide, titanium dioxide, adopts more than one at least.Promoter is methyl salicylate, Camphora, Mentholum, adopts more than one at least.Gel matrix is pressure sensitive adhesive, resin glue, rubber, adopts more than one at least.
The present invention is the patch and the manufacture method of treatment intervertebral disk hernia.Extract medical material with scientific method processing, fill in the skeleton that is stated from substrate, paster substrate and skin intermiscibility are good, help drug molecule and pass through, drug release is slow, and administration is steady, zest is little, do not have toxic and side effects, can alleviate disease rapidly, easy to use, medicine is cheap simultaneously, therapeutic effect is good, the toxic and side effects of having avoided oral drugs and injection that human body is brought, also without liver first-pass effect and gastral release light.Can be through the skin iuntercellular with blood circulation to focus, improve bioavailability more than 10 times than like product, therapeutic effect has significance to improve.
The specific embodiment
Embodiment 1 (high dose)
Treatment patch of intervertebral disk hernia and manufacture method be crude drug by weight ratio every part in 1kg, make according to following method: Cortex Eucommiae 10kg, Radix Dipsaci 10kg, Pheretima 10kg.
Respectively the Cortex Eucommiae, Radix Dipsaci and Pheretima powder are broken into coarse powder, decoct with water 1-3 time respectively then, each 1-3 hour, collecting decoction filtered, and surveying relative density when filtrate is concentrated into 80 ℃ is the clear paste of 1.00-1.20.
Merge above-mentioned clear paste, surveying relative density when continuing to be concentrated into 80 ℃ is the clear paste of 1.10-1.30, adds dressing then; Dressing is: polyvinyl alcohol 60kg, gelatin 120kg, sodium carboxymethyl cellulose 60kg, 480 parts of glycerol and an amount of distilled water, add mix homogeneously, and be prepared into cloth cream.
Cloth cream is coated on cloth or non-woven fabrics or the polyethylene sheets, and the low humidity drying is pasted on the ventilative adhesive plaster, and the lid lining is cut into pieces, quality inspection, packing warehouse-in.
Embodiment 2 (low dosage)
Treatment patch of intervertebral disk hernia and manufacture method be crude drug by weight ratio every part in 1kg, make according to following method: Cortex Eucommiae 5kg, Radix Dipsaci 3kg, Pheretima 3kg.
Respectively the Cortex Eucommiae, Radix Dipsaci and Pheretima powder are broken into coarse powder, decoct with water 1-3 time respectively then, each 1-3 hour, collecting decoction filtered, and surveying relative density when filtrate is concentrated into 80 ℃ is the clear paste of 1.00-1.20.
Merge above-mentioned clear paste, surveying relative density when continuing to be concentrated into 80 ℃ is the clear paste of 1.10-1.30, adds dressing then; Dressing is: polyvinyl alcohol 60kg, gelatin 120kg, sodium carboxymethyl cellulose 60kg, 480 parts of glycerol and an amount of distilled water, add mix homogeneously, and be prepared into cloth cream.
Cloth cream is coated on cloth or non-woven fabrics or the polyethylene sheets, and the low humidity drying is pasted on the ventilative adhesive plaster, and the lid lining is cut into pieces, quality inspection, packing warehouse-in.
Embodiment 3 (median dose)
Treatment patch of intervertebral disk hernia and manufacture method be crude drug by weight ratio every part in 1kg, make according to following method: Cortex Eucommiae 7.5kg, Radix Dipsaci 6.5kg, Pheretima 6.5kg.
Respectively the Cortex Eucommiae, Radix Dipsaci and Pheretima powder are broken into coarse powder, decoct with water 1-3 time respectively then, each 1-3 hour, collecting decoction filtered, and surveying relative density when filtrate is concentrated into 80 ℃ is the clear paste of 1.00-1.20.
Merge above-mentioned clear paste, surveying relative density when continuing to be concentrated into 80 ℃ is the clear paste of 1.10-1.30, adds dressing then; Dressing is: polyvinyl alcohol 60kg, gelatin 120kg, sodium carboxymethyl cellulose 60kg, 480 parts of glycerol and an amount of distilled water, add mix homogeneously, and be prepared into cloth cream.
Cloth cream is coated on cloth or non-woven fabrics or the polyethylene sheets, and the low humidity drying is pasted on the ventilative adhesive plaster, and the lid lining is cut into pieces, quality inspection, packing warehouse-in.
Claims (3)
1, a kind of patch for the treatment of intervertebral disk hernia is characterized in that being: it is made up of following weight proportion component: Cortex Eucommiae 5-10 part, Radix Dipsaci 3-10 part, Pheretima 3-10 part.
2, a kind of patch and manufacture method for the treatment of intervertebral disk hernia is characterized in that: it is that the crude drug of following column weight amount proportioning part is made according to following method: Cortex Eucommiae 5-10 part, Radix Dipsaci 3-10 part, Pheretima 3-10 part; Respectively the Cortex Eucommiae, Radix Dipsaci and Pheretima powder are broken into coarse powder, decoct with water 1-3 time respectively then, each 1-3 hour, collecting decoction filtered, and surveying relative density when filtrate is concentrated into 80 ℃ is the clear paste of 1.00-1.20; Merge above-mentioned clear paste, surveying relative density when continuing to be concentrated into 80 ℃ is the clear paste of 1.10-1.30, adds dressing then; Dressing is: 60 parts of polyvinyl alcohol, 120 parts in gelatin, 60 parts of sodium carboxymethyl cellulose, 480 parts of glycerol and an amount of distilled water, add mix homogeneously, and be prepared into cloth cream; Cloth cream is coated on cloth or non-woven fabrics or the polyethylene sheets, and cold drying is pasted on the ventilative adhesive plaster, and the lid lining cuts into pieces, quality inspection, finished product packing warehouse-in.
3, the patch of treatment intervertebral disk hernia according to claim 2 and manufacture method is characterized in that dressing is Kaolin, bentonite, zinc oxide, titanium dioxide, adopts more than one at least; Promoter is methyl salicylate, Camphora, Mentholum, adopts more than one at least; Gel matrix is pressure sensitive adhesive, resin glue, rubber, adopts more than one at least.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN200810151815A CN101683374A (en) | 2008-09-26 | 2008-09-26 | Patch for treating disc herniation and method for producing the same |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN200810151815A CN101683374A (en) | 2008-09-26 | 2008-09-26 | Patch for treating disc herniation and method for producing the same |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN101683374A true CN101683374A (en) | 2010-03-31 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN200810151815A Withdrawn CN101683374A (en) | 2008-09-26 | 2008-09-26 | Patch for treating disc herniation and method for producing the same |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN101683374A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109045069A (en) * | 2018-11-09 | 2018-12-21 | 四川农业大学 | A kind of pheretima syrup nano-silver water gel patch and preparation method thereof |
-
2008
- 2008-09-26 CN CN200810151815A patent/CN101683374A/en not_active Withdrawn
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109045069A (en) * | 2018-11-09 | 2018-12-21 | 四川农业大学 | A kind of pheretima syrup nano-silver water gel patch and preparation method thereof |
| CN109045069B (en) * | 2018-11-09 | 2021-11-26 | 四川农业大学 | Earthworm syrup nano-silver hydrogel patch and preparation method thereof |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C04 | Withdrawal of patent application after publication (patent law 2001) | ||
| WW01 | Invention patent application withdrawn after publication |
Open date: 20100331 |