CN109045069A - A kind of pheretima syrup nano-silver water gel patch and preparation method thereof - Google Patents
A kind of pheretima syrup nano-silver water gel patch and preparation method thereof Download PDFInfo
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Abstract
The invention discloses a kind of pheretima syrup nano-silver water gel patch and preparation method thereof, which includes preparation pheretima syrup；Prepare nano silver colloidal sol；Prepare pheretima syrup nano-silver water gel patch.Patch of the present invention is to joined anti-biotic material nano silver in pheretima syrup, and " combination among the strong ones " is allowed to highly effective and safe and is not likely to produce drug resistance；Novel form hydrogel patch is made, not only Energy and comfort, not pollution clothes, utilization ratio of drug is high, while its moisturizing feature plays the role of continued down and facilitates wound healing, improves the drug effect and quality of product.
Description
Technical field
The invention belongs to medicament research and development technical fields, specifically, being related to a kind of pheretima syrup nano-silver water gel patch
And preparation method thereof.
Background technique
The reason of burn and scald is the unexpected injury being frequently run onto our daily lifes, causes burn and scald is different, but treats
The problems such as First Principles of burn and scald are all very consistent, are typically necessary heat-clearing and solve trauma surface infestation, pain, healing.It burns at present
There are many kinds of main for scald medicament including two broad aspect of Chinese medicine and Western medicine, and Chinese medicine takes effect slowly, prepares complex, Western medicine drug effect
Though fastly but being also easy to produce drug resistance；It is mostly paste in terms of dosage form, finish etc., easily pollution clothes are inconvenient for use.
Pheretima is the hirudo leech of Ju Yin section animal Pheretima aspergillum or allolobophora caliginosa trapezoides, medicinal first recorded in Zhou Dynasty " Book of Songs ", successive dynasties doctor
Monograph is learned to include also known as earthworm, earthworm, hard silkworm, earth ridge etc..Pheretima property is salty-cold, and tool heat-clearing calms the frightened, relievings asthma, dredging collateral, work
The effect of blood, just on the books in Compendium of Material Medica: pheretima can treat dispute gruel sore of festering, be clinically commonly used to treatment burn and scald,
Lower limb such as fester at a variety of diseases.Modern pharmacological research, pheretima have decompression, antithrombotic, thrombolysis and improve blood circulation, relieving asthma, resist
The effects of arrhythmia cordis, antipyretic and anti-inflammatory analgesia, acceleration of wound healing.In recent years, many Chinese and overseas scholars have carried out pheretima in wound
Healing aspect act on research, research find pheretima contain lumbricin, earthworm alkali, amino acid, alkaloid, linoleic acid, peptides and
The a variety of active ingredients such as zinc have removing toxic substances, activating microcirculation and removing stasis medicinal and apparent anti-inflammatory anti-infectious function, can promote capillary, at
Fibrocyte and myofibroblast hyperplasia, can accelerate the process of tissue reparation of the surface of a wound.Zhou Ying et al. research is pointed out: earthworm egg
It is white to promote rat fibroblast (NIH on a molecular scale3T3) proliferation and collagen synthesis, thus macroscopically promoting rat
(Zhou Ying, Xi Wang, Song Shuliang wait the rush of earthworm protein II degree of scald deep to rat more to act in [J] for the healing of depthⅡ° scald
Magnificent wound magazine, 2010,26 (4): 377-379.).
Pheretima syrup is a kind of time-honored civil folk prescription, can be used for treating mumps, shingles zoster, lower limb
The outer disease of a variety of skins such as ulcer, erysipelas, burn and scald.Its material is easy to get, and preparation is simple, that is, takes fresh pheretima several, cleans, puts
Into cleaning container in and appropriate white granulated sugar is added, for a long time after, pheretima body fluid constantly oozes out, and polypide gradually atrophy can obtain light
The leachate of yellow, as pheretima syrup.The folk prescription brings notable results in civil medication, very widely used, early in the seventies
Begin to use pheretima syrup to treat burn and scald with regard to someone, and achieves more satisfied curative effect.Pheretima white sugar leaching is white
Sugar is cool in nature, and white sugar immersion liquid is hypertonic solution, has water suction corrosion-resistant effect, and pheretima energy heat-clearing sore cold in nature is promoting blood circulation and removing obstruction in channels.The two
In conjunction with can not only be clearing heat and detoxicating, the effect of expelling pus and promoting granulation can also protect pain nerve tip, play activating microcirculation and removing stasis medicinal, have bright
Aobvious analgesic effect；And promote wound healing, it is anti-infective the effects of, therefore have good therapeutic effect to burn and scald.According to investigation, use
Pheretima syrup treats burn and scald, and surface of a wound without pain, exudation and infection can control rapidly original infective wound surface, burn and scald within II °
The surface of a wound heals within 2 weeks, and seldom there are scar after healing, shallow III ° of empyrosis wound surface heals within 3 weeks, there are slight scar,
Surface of a wound new life scar, cure rate 100% are not found.
Silver is used as a kind of most common antibacterial agent, have many advantages, such as efficiently, it is wide spectrum, safe, be widely used in antibacterial with
In mould proof product, and nano silver is as 21 century novel high polymer material, in antibacterial, catalysis, lubricant, optics, conduction, biology
The fields such as material all have broad application prospects, and due to the highly-safe, efficient of nano silver, wide spectrum and are not likely to produce drug resistance
The advantages that, it is even more one of research hotspot in field of medicaments.Sichuan Province Zigong City Fushun County morning twilight hospital burn department is several years ago
Start using nano silver burn patch treatment small-area burn, and excellent treatment effect, safety are higher.And Nanometer silver dressing exists
Other main compound substances of burn and scald aspect are controlled, no such as moist exposed burn cream (moist exposed burn ointment, MEBO)
Infection can be only prevented and treated, wound healing is accelerated, moreover it is possible to effectively mitigate later period cicatricial contracture.Match using nano silver medical antibacterial dressing
Rationally correctly treatment and nursing, can be improved cure rate, promotes SD-Ag Cream, reduce and avoid the generation of scar；It removes
Except this, nano silver gel is clinically also usually applied, has double action that is anti-infective and promoting healing to infective wound surface,
It follows that nano silver is very advantageous in terms for the treatment of burn and scald.
Hydrogel patch also known as cataplasm are that drug is added, is coated on using water-soluble high-molecular material as main matrix
Manufactured external use plaster on non-woven fabrics belongs to a kind of dosage form of transdermal delivery system；Occur first in Japan in the seventies.Phase
Compare other drugs dosage form, the dosage form drugloading rate is big, and dosage is accurate, and applicating property and moisture retention are good, and no sensitization and irritation make
With conveniently, comfortably, pollution clothes, will not occur the adverse reactions such as lead poisoning.Therefore, hydrogel patch is considered as a kind of pole
Has the new formulation of market potential.And the study found that hydrogel patch can reinforce the transdermal penetration of protein, and do not influence
The activity of protein.The basic composition of hydrogel plaster substrate generally comprises cross-linked scaffold, crosslinking agent, cross-linking regulator, thickening
Agent, moisturizer, penetrating agent and distilled water.Adhesion is the important indicator for evaluating hydrogel adhesive quality, and whether patch can jail
It adheres and is affixed on skin surface, be the key that its percutaneous absorbtion that can effectively carry out drug.Adhesion strength include initial bonding strength, hold it is viscous
Power, peeling force.
Pheretima syrup treats burn and scald or sore carbuncle as civil folk prescription, and exclusive use will appear the shelf-life and not grow, and is easy to grow
Waterborne pathogenic microorganisms or it is rotten the problems such as, so as to cause risks such as wound infections, burn and scald or ulceration wound cannot be played
The effect of anti-inflammatory sterilization.And pheretima syrup is used alone and needs repeated multiple times administration, and is easy pollution clothes, drug carries and storage
Deposit equal inconvenience.Though nano silver has bactericidal antiphlogistic for burn and scald or sore carbuncle wound, pre- aseptic effect can not promote
The healing of wound.And nano silver cannot be used directly for ulceration wound, if being used for ulceration wound or mucous membrane, nano-silver ionic holds
Mucocutaneous human body barriers are easily passed through, through blood circulation, to reach the other organs of human body and position is accumulated, in turn
Liver cell, nerve cell may be damaged.When a large amount of silver ions are after people's internal deposition, irreversible shadow but will be generated to human body
It rings.
During pheretima syrup and nano silver combine, since nano silver is very thin powder, in pheretima syrup and base
It is difficult to be uniformly mixed in matter, therefore, it is necessary to which providing a kind of new ensures that distribution of the nano silver in pheretima syrup and matrix is equal
Even pheretima syrupy product.
Summary of the invention
In view of this, the present invention, which is directed to traditional pheretima syrup, to be stored, apt to deteriorate, quality is not easy to control, using not
It is convenient, clothing easy to pollute, and antibacterial anti-inflammatory can not be played the role of, nano silver can not directly act on burn and scald and the sore carbuncle surface of a wound
The problem of, provide a kind of pheretima syrup nano-silver water gel patch and preparation method thereof.
In order to solve the above-mentioned technical problem, the invention discloses a kind of preparation sides of pheretima syrup nano-silver water gel patch
Method, comprising the following steps:
Step 1, preparation pheretima syrup: taking pheretima to be dipped in clear water and clean soil, and taking-up is placed on blotting paper the moisture that exhausts,
Pretreated pheretima is obtained, pretreated pheretima is mixed with white sugar, is stood, body fluid and atrophy is gradually precipitated in pheretima；
By mixture centrifugation, filtering 2-3 times, taking its leachate is pheretima syrup；
Step 2 prepares nano silver colloidal sol: taking nano silver to be placed in distilled water, is ultrasonically treated to get nano silver colloidal sol is arrived；
Step 3, preparation pheretima syrup nano-silver water gel patch: selection Sodium Polyacrylate is cross-linked scaffold, and Dihydroxyaluminium Aminoacetate is
Crosslinking agent, glycerol are moisturizer, and EDTA and tartaric acid are cross-linking regulator, and carbomer, CMC-Na, PVPk30 are tackifier, third
Glycol is penetrating agent, and pheretima syrup nano-silver water gel patch is prepared.
Optionally, the mass ratio of the pretreated pheretima and white sugar is 1:0.6-1:1.6, and time of repose is to stand
1.5-2.5h。
Optionally, the mass volume ratio (g/L) of the nano silver in the step 2 and distilled water is 1:20-8:20, when ultrasonic
Between be 5-15min.
Optionally, the preparation pheretima syrup nano-silver water gel patch in the step 3 specifically:
Glycerol and ethylene glycol are mixed and are stirred by step 3.1, and EDTA is first added, after being sufficiently stirred, adds
Dihydroxyaluminium Aminoacetate, after being sufficiently stirred, as A phase；
Step 3.2 uses Sodium Polyacrylate, CMC-Na and PVPK30 equivalent mixing method of progressively increasing to be uniformly mixed as B phase；
Carbomer is added in distilled water step 3.3, and object wetting to be polymerized stirs abundant standby and is used as C phase；
Tartaric acid and kaolin are successively dissolved in distilled water by step 3.4, are eventually adding pheretima syrup and nano silver is molten
Glue is used as D phase after stirring sufficiently；
B is added to A phase, after 6min, C is added in AB mixed phase, is stirred by step 3.5, under agitation
2min is eventually adding D phase, stirs 20min, is then uniformly applied on non-woven fabrics after ultrasonic degassing 15min, dries 0.5h, room temperature
Solidify 48h, back sheet is covered, with a thickness of 1.5mm, sealed package, room temperature preservation.
Optionally, the mass ratio of the glycerol in the step 3.1 and ethylene glycol is 4.5:1-5:1；Glycerol and ethylene glycol are mixed
Conjunction speed of agitator is 230-280r/min, mixing time 1-3min；The mass ratio of EDTA and glycerol is 0.01:1-0.01:
1.5；The mass ratio of Dihydroxyaluminium Aminoacetate and glycerol is 1:48-2:48；EDTA is added and Dihydroxyaluminium Aminoacetate stirs 3-8min respectively.
Optionally, the mass ratio of the Sodium Polyacrylate in the step 3.2, CMC-Na and PVPK30 are 12-15:3-8:1-
5, CMC-Na and Dihydroxyaluminium Aminoacetate mass ratio be 1:0.1-1:0.5.
Optionally, the mass ratio of the carbomer in the step 3.3 and distilled water is 0.2:15-0.6:15；Speed of agitator
280-320r/min, mixing time 25-35min, wherein the mass ratio of carbomer and Dihydroxyaluminium Aminoacetate is 5:3-10:3.
Optionally, the tartaric acid in the step 3.4 and kaolinic mass ratio are 1:3-3:3；Pheretima syrup and winestone
The volume mass ratio (ml/g) of acid is 1:0.02-1:0.06；The volume mass of nano silver colloidal sol and tartaric acid ratio (ml/g) is 1:
0.1-1:0.15；Speed of agitator is 220-280r/min, mixing time 3-8min, and the mass ratio of tartaric acid and Dihydroxyaluminium Aminoacetate is 2:
5-6:5。
Optionally, the speed of agitator 220-280r/min in the step 3.5.
The invention also discloses a kind of pheretima syrup nano-silver water gel patches that above-mentioned preparation method is prepared.
Compared with prior art, the present invention can be obtained including following technical effect:
Pheretima syrup nano-silver water gel patch of the present invention is to joined anti-biotic material nano silver in pheretima syrup, " strong
Strong joint ", is allowed to highly effective and safe and is not likely to produce drug resistance；Novel form hydrogel patch is made, not only Energy and comfort, it is not dirty
Clothing is contaminated, utilization ratio of drug is high, while its moisturizing feature plays the role of continued down and facilitates wound healing, improves product
Drug effect and quality, provide new thinking for the exploitation of conventional medicament, be application of the Modern preparations technology on conventional medicament
Provide reference.
Certainly, it implements any of the products of the present invention it is not absolutely required to while reaching all the above technical effect.
Specific embodiment
Carry out the embodiment that the present invention will be described in detail below in conjunction with embodiment, whereby to the present invention how application technology hand
Section solves technical problem and reaches the realization process of technical effect to fully understand and implement.
The invention discloses a kind of preparation methods of pheretima syrup nano-silver water gel patch, comprising the following steps:
Step 1, preparation pheretima syrup: taking pheretima to be dipped in clear water and clean soil, and taking-up is placed on blotting paper the moisture that exhausts,
Pretreated pheretima is obtained, pretreated pheretima is mixed with white sugar, wherein the quality of pretreated pheretima and white sugar
Than for 1:0.6-1:1.6, standing 1.5-2.5h, body fluid is gradually precipitated and atrophy in pheretima；By mixture centrifugation, filter 2-3 times,
Taking its leachate is pheretima syrup；
Step 2 prepares nano silver: taking nano silver to be placed in distilled water, is ultrasonically treated 5-15min to get molten to nano silver
Glue；Wherein, the mass volume ratio (g/L) of nano silver and distilled water is 1:20-8:20；
Step 3, preparation pheretima syrup nano-silver water gel patch: selection Sodium Polyacrylate is cross-linked scaffold, and Dihydroxyaluminium Aminoacetate is
Crosslinking agent, glycerol are moisturizer, and EDTA and tartaric acid are cross-linking regulator, and carbomer, CMC-Na, PVPk30 are tackifier, third
Glycol is penetrating agent, and pheretima syrup nano-silver water gel patch is prepared.
Glycerol and ethylene glycol are mixed and are stirred 1-3min, speed of agitator 230-280r/ by step 3.1
The mass ratio of min, glycerol and ethylene glycol is 4.5:1-5:1；Sequentially add EDTA and Dihydroxyaluminium Aminoacetate, the mass ratio of EDTA and glycerol is
0.01:1-0.01:1.5；The mass ratio of Dihydroxyaluminium Aminoacetate and glycerol is 1:48-2:48；Stirring 3-8min is as A phase respectively；
Step 3.2 uses Sodium Polyacrylate, CMC-Na and PVPK30 equivalent mixing method of progressively increasing to be uniformly mixed as B phase；Its
In, the mass ratio of Sodium Polyacrylate, CMC-Na and PVPK30 is 12-15:3-8:1-5, and the mass ratio of CMC-Na and Dihydroxyaluminium Aminoacetate is
1:0.1-1:0.5；
Carbomer is added in distilled water step 3.3, and object wetting stirring 25-35min standby to be polymerized is used as C phase；Its
In, the mass ratio of carbomer and distilled water is 0.2:15-0.6:15；The mass ratio of carbomer and Dihydroxyaluminium Aminoacetate is 5:3-10:3；
Tartaric acid and kaolin are successively dissolved in distilled water by step 3.4, are eventually adding pheretima syrup and nano silver is molten
Glue, 220-280r/min stir 3-8min as D phase；Wherein, tartaric acid and kaolinic mass ratio are 1:3-3:3；Pheretima sugar
The volume mass ratio (ml/g) of slurry and tartaric acid is 1:0.02-1:0.06；The volume mass of nano silver colloidal sol and tartaric acid ratio
It (ml/g) is 1:0.1-1:0.15；The mass ratio of tartaric acid and Dihydroxyaluminium Aminoacetate is 2:5-6:5；
Step 3.5, under 220-280r/min stirring condition, B is added to A phase, after 6min, C is added to AB and is mixed
Xiang Zhong stirs 2min, is eventually adding D phase, stirs 20min, is then uniformly applied on non-woven fabrics after ultrasonic degassing 15min, dries
0.5h, room temperature curing 48h, covers backing, with a thickness of 1.5mm, sealed package, room temperature preservation.
Embodiment 1
(1) it prepares pheretima syrup: taking pheretima to be dipped in clear water and clean soil, taking-up is placed on blotting paper the moisture that exhausts, and claims
In the clean beaker for taking 10g investment 50mL, 5g white sugar is added, stands, body fluid and atrophy is gradually precipitated in pheretima.It will mixing after 2h
Object centrifugation, filtering 2-3 times, taking its leachate is pheretima syrup.
(2) it prepares nano silver: nano silver being taken to be placed in distilled water, be ultrasonically treated 10min to get nano silver colloidal sol is arrived；Its
In, the mass volume ratio (g/L) of nano silver and distilled water is 4:20；
(3) prepare hydrogel patch: selection Sodium Polyacrylate is cross-linked scaffold, and Dihydroxyaluminium Aminoacetate is crosslinking agent, and glycerol is moisturizing
Agent, EDTA and tartaric acid are cross-linking regulator, and carbomer, CMC-Na, PVPk30 are tackifier, and propylene glycol is penetrating agent.It weighs
9.6g glycerol, 2g ethylene glycol are in clean beaker, at 250r/min, stir 2min, it is sweet to sequentially add 0.04gEDTA, 0.15g
Hydroxyl aluminium stirs 5min as A phase respectively；Weigh 1.34g Sodium Polyacrylate, 0.5gCMC-Na, 0.3gPVPK30 are progressively increased with equivalent
Mixing method, which is uniformly mixed, is used as B phase；It weighs 0.4g carbomer to be added in 15g distilled water, after object wetting to be polymerized, with 300r/min
30min is stirred, it is spare to be used as C phase；Weigh 0.12g tartaric acid, 0.18g kaolin is successively dissolved in distilled water, be eventually adding
3mL pheretima syrup and 1mL nano silver colloidal sol, 250r/min stir 5min as D phase；Under 250r/min stirring, B is added to
After 6min or so, C is added in AB mixed phase for A phase, stirs 2min, is eventually adding D phase, stirs 20min, and then ultrasound is de-
It is uniformly applied on non-woven fabrics after gas 15min, dries 0.5h, room temperature curing 48h covers backing, with a thickness of 1.5mm or so, sealing
Packaging, room temperature preservation.
Embodiment 2
Step 1, preparation pheretima syrup: taking pheretima to be dipped in clear water and clean soil, and taking-up is placed on blotting paper the moisture that exhausts,
Pretreated pheretima is obtained, pretreated pheretima is mixed with white sugar, wherein the quality of pretreated pheretima and white sugar
Than for 1:0.6, standing 2.5h, body fluid is gradually precipitated and atrophy in pheretima；By mixture centrifugation, filtering 2-3 times, its leachate is taken
As pheretima syrup；
Step 2 prepares nano silver: taking nano silver to be placed in distilled water, is ultrasonically treated 15min to get nano silver colloidal sol is arrived；
Wherein, the mass volume ratio (g/L) of nano silver and distilled water is 1:20；
Step 3, preparation pheretima syrup nano-silver water gel patch: selection Sodium Polyacrylate is cross-linked scaffold, and Dihydroxyaluminium Aminoacetate is
Crosslinking agent, glycerol are moisturizer, and EDTA and tartaric acid are cross-linking regulator, and carbomer, CMC-Na, PVPk30 are tackifier, third
Glycol is penetrating agent, and pheretima syrup nano-silver water gel patch is prepared.
Glycerol and ethylene glycol are mixed and are stirred 1min, speed of agitator 280r/min, glycerol by step 3.1
Mass ratio with ethylene glycol is 4.5:1；Sequentially add EDTA and Dihydroxyaluminium Aminoacetate, the mass ratio of EDTA and glycerol is 0.01:1.5；It is sweet
The mass ratio of hydroxyl aluminium and glycerol is 1:48；Stirring 8min is as A phase respectively；
Step 3.2 uses Sodium Polyacrylate, CMC-Na and PVPK30 equivalent mixing method of progressively increasing to be uniformly mixed as B phase；Its
In, the mass ratio of Sodium Polyacrylate, CMC-Na and PVPK30 is 12:8:1, and the mass ratio of CMC-Na and Dihydroxyaluminium Aminoacetate is 1:0.5；
Carbomer is added in distilled water step 3.3, and object wetting stirring 25min standby to be polymerized is used as C phase；Wherein,
The mass ratio of carbomer and distilled water is 0.6:15；The mass ratio of carbomer and Dihydroxyaluminium Aminoacetate is 5:3；
Tartaric acid and kaolin are successively dissolved in distilled water by step 3.4, are eventually adding pheretima syrup and nano silver is molten
Glue, 280r/min stir 3min as D phase；Wherein, tartaric acid and kaolinic mass ratio are 1:3；Pheretima syrup and tartaric acid
Volume mass ratio (ml/g) be 1:0.06；The volume mass of nano silver colloidal sol and tartaric acid ratio (ml/g) is 1:0.1；Tartaric acid
Mass ratio with Dihydroxyaluminium Aminoacetate is 6:5；
Step 3.5, under 220r/min stirring condition, B is added to A phase, after 6min, C is added in AB mixed phase,
2min is stirred, D phase is eventually adding, 20min is stirred, is then uniformly applied on non-woven fabrics after ultrasonic degassing 15min, dries 0.5h,
Room temperature curing 48h, covers backing, with a thickness of 1.5mm, sealed package, room temperature preservation.
Embodiment 3
Step 1, preparation pheretima syrup: taking pheretima to be dipped in clear water and clean soil, and taking-up is placed on blotting paper the moisture that exhausts,
Pretreated pheretima is obtained, pretreated pheretima is mixed with white sugar, wherein the quality of pretreated pheretima and white sugar
Than for 1:1.6, standing 1.5h, body fluid is gradually precipitated and atrophy in pheretima；By mixture centrifugation, filtering 2-3 times, its leachate is taken
As pheretima syrup；
Step 2 prepares nano silver: taking nano silver to be placed in distilled water, is ultrasonically treated 5min to get nano silver colloidal sol is arrived；
Wherein, the mass volume ratio (g/L) of nano silver and distilled water is 8:20；
Step 3, preparation pheretima syrup nano-silver water gel patch: selection Sodium Polyacrylate is cross-linked scaffold, and Dihydroxyaluminium Aminoacetate is
Crosslinking agent, glycerol are moisturizer, and EDTA and tartaric acid are cross-linking regulator, and carbomer, CMC-Na, PVPk30 are tackifier, third
Glycol is penetrating agent, and pheretima syrup nano-silver water gel patch is prepared.
Glycerol and ethylene glycol are mixed and are stirred 3min, speed of agitator 230r/min, glycerol by step 3.1
Mass ratio with ethylene glycol is 5:1；Sequentially add EDTA and Dihydroxyaluminium Aminoacetate, the mass ratio of EDTA and glycerol is 0.01:1；Dihydroxyaluminium Aminoacetate
Mass ratio with glycerol is 2:48；Stirring 3min is as A phase respectively；
Step 3.2 uses Sodium Polyacrylate, CMC-Na and PVPK30 equivalent mixing method of progressively increasing to be uniformly mixed as B phase；Its
In, the mass ratio of Sodium Polyacrylate, CMC-Na and PVPK30 is 15:3:5, and the mass ratio of CMC-Na and Dihydroxyaluminium Aminoacetate is 1:0.1；
Carbomer is added in distilled water step 3.3, is used as dispersion liquid stirring 35min standby after object wetting to be polymerized
For C phase；Wherein, the mass ratio of carbomer and distilled water is 0.2:15；The mass ratio of carbomer and Dihydroxyaluminium Aminoacetate is 10:3；
Tartaric acid and kaolin are successively dissolved in distilled water by step 3.4, are eventually adding pheretima syrup and nano silver is molten
Glue, 220r/min stir 8min as D phase；Wherein, tartaric acid and kaolinic mass ratio are 1:3-3:3；Pheretima syrup and wine
The volume mass ratio (ml/g) of stone acid is 1:0.02；The volume mass of nano silver colloidal sol and tartaric acid ratio (ml/g) is 1:0.15；
The mass ratio of tartaric acid and Dihydroxyaluminium Aminoacetate is 2:5；
Step 3.5, under 280r/min stirring condition, B is added to A phase, after 6min, C is added in AB mixed phase,
2min is stirred, D phase is eventually adding, 20min is stirred, is then uniformly applied on non-woven fabrics after ultrasonic degassing 15min, dries 0.5h,
Room temperature curing 48h, covers backing, with a thickness of 1.5mm, sealed package, room temperature preservation.
Comparative example 1
Using commercially available pheretima syrup.
Technical effect of the invention is illustrated below with reference to specific experimental data:
1, initial bonding strength measurement and evaluation: test sample is placed in 30 ° of hang plate center, and its cream is made to face upward, on inclined-plane
Portion 10cm and the covering of the mylar of lower part 15cm thickness, centre reserves 5cm cream face, by the steel ball under each specification item from 30 °
It is freely rolled down on slope board, the maximum number steel ball that observation cataplasm cream face can be clung evaluates the size of its initial bonding strength.In advance
Whether compared with big steel ball, observing the steel ball rolled down can be stuck in test section and (stop mobile more than 5 seconds) for choosing, from big to small, use
The steel ball of different model is tested, the steel ball until finding the maximum number that test section is stuck.Take aforementioned can be stuck most
Two balls of the steel ball of big ball number and size adjacent thereto, respectively carry out a test on same test sample, to confirm maximum
Steel ball ball number.Standards of grading are shown in Table 1.
1 initial bonding strength standards of grading table of table
Embodiment 1-3 and the measurement of the initial bonding strength of comparative example 1 and evaluation are shown in Table 2.
2 embodiment 1-3 of table and the measurement of the initial bonding strength of comparative example 1 and evaluation
| Initial bonding strength scores (dividing) | |
| Embodiment 1 | 85 |
| Embodiment 2 | 88 |
| Embodiment 3 | 84 |
| Comparative example 1 | 73 |
2, holding power measurement and evaluation.Before test, test sample backing is removed, so that it is not overlapped placement 2 at room temperature small
When more than.Experimental plate and load plate are cleaned with Wiping material, is dried, is cleaned repeatedly more than three times with clean gauze afterwards,
The not handy hand of plate face or the contact of other objects until the working face cleaning of plate, after cleaning.Test sample is longitudinally pasted onto
The middle part of the experimental plate and load plate that are located next to, with pressure roller on test sample come rollback pressure three times, after test sample is onboard pasted,
It places 20 minutes, is fixed on experiment frame, the time of record test starting after adding 200g weight.Standards of grading are shown in Table 3.
3 holding power standards of grading table of table
Embodiment 1-3 and the scoring of the holding power of comparative example 1 are shown in Table 4.
4 embodiment 1-3 of table and the scoring of the holding power of comparative example 1
| Holding power scores (dividing) | |
| Embodiment 1 | 83 |
| Embodiment 2 | 86 |
| Embodiment 3 | 85 |
| Comparative example 1 | 55 |
3, peeling force measurement and evaluation.The anti-stick layer on the surface hydrogel patch (10cm × 10cm) is removed, and is pasted
On clean steel plate, rolled back and forth for several times with the ball of 2kg；One end (about 2cm) that hydrogel patch is opened after 10min, is used in combination
Spring scale is clamped (with steel plate at 180 °)；Hydrogel patch is then removed with given pace, it is big to record 1 peeling force at interval of 5s
It is small, and using the average value of 3 peeling forces of METHOD FOR CONTINUOUS DETERMINATION as measurement index.Standards of grading are shown in Table 5.
5 peeling force standards of grading table of table
The scoring of the peeling force of embodiment 1-3 and comparative example 1 is shown in Table 6.
The scoring of the peeling force of 6 embodiment 1-3 of table and comparative example 1
4, complexity, stickiness ocular estimate: are stirred by lotion；Observe whether the patch surface made is bright and clean, has
Bubble-free, whether there is or not particles；Observation back sheet is whether there is or not oozing out and being affixed on whether skin remains, to evaluate the outer of hydrogel patch
It sees, standards of grading are shown in Table 7.
7 appearance standards of grading table of table
The pheretima syrup nano-silver water gel patch ocular estimate that embodiment 1-3 and comparative example 1 are prepared is shown in Table 8.
The pheretima syrup nano-silver water gel patch ocular estimate that 8 embodiment 1-3 of table and comparative example 1 are prepared
Above description has shown and described several preferred embodiments of invention, but as previously described, it should be understood that invention is not
It is confined to form disclosed herein, should not be regarded as an exclusion of other examples, and can be used for various other combinations, modification
And environment, and can be carried out within that scope of the inventive concept describe herein by the above teachings or related fields of technology or knowledge
Change.And changes and modifications made by those skilled in the art do not depart from the spirit and scope of invention, then it all should be in the appended power of invention
In the protection scope that benefit requires.
Claims (10)
1. a kind of preparation method of pheretima syrup nano-silver water gel patch, which comprises the following steps:
Step 1, preparation pheretima syrup: taking pheretima to be dipped in clear water and clean soil, and taking-up is placed on blotting paper the moisture that exhausts, and obtains
Pretreated pheretima mixes pretreated pheretima with white sugar, stands, and body fluid and atrophy is gradually precipitated in pheretima；It will mix
Object centrifugation, filtering 2-3 times is closed, taking its leachate is pheretima syrup；
Step 2 prepares nano silver colloidal sol: taking nano silver to be placed in distilled water, is ultrasonically treated to get nano silver colloidal sol is arrived；
Step 3, preparation pheretima syrup nano-silver water gel patch: selection Sodium Polyacrylate is cross-linked scaffold, and Dihydroxyaluminium Aminoacetate is crosslinking
Agent, glycerol are moisturizer, and EDTA and tartaric acid are cross-linking regulator, and carbomer, CMC-Na, PVPk30 are tackifier, propylene glycol
For penetrating agent, pheretima syrup nano-silver water gel patch is prepared.
2. preparation method according to claim 1, which is characterized in that the mass ratio of the pretreated pheretima and white sugar
For 1:0.6-1:1.6, time of repose is to stand 1.5-2.5h.
3. preparation method according to claim 1, which is characterized in that the matter of nano silver and distilled water in the step 2
Measuring volume ratio (g/L) is 1:20-8:20, ultrasonic time 5-15min.
4. preparation method according to claim 1, which is characterized in that the preparation pheretima syrup nano silver in the step 3
Hydrogel patch specifically:
Glycerol and ethylene glycol are mixed and are stirred by step 3.1, and EDTA is first added, and after being sufficiently stirred, add sweet hydroxyl
Aluminium, after being sufficiently stirred, as A phase；
Step 3.2 uses Sodium Polyacrylate, CMC-Na and PVPK30 equivalent mixing method of progressively increasing to be uniformly mixed as B phase；
Carbomer is added in distilled water step 3.3, and object wetting to be polymerized stirs abundant standby and is used as C phase；
Tartaric acid and kaolin are successively dissolved in distilled water by step 3.4, are eventually adding pheretima syrup and nano silver colloidal sol,
D phase is used as after stirring sufficiently；
B is added to A phase, after 6min, C is added in AB mixed phase, stirs 2min, most by step 3.5, under agitation
D phase is added afterwards, stirs 20min, is then uniformly applied on non-woven fabrics after ultrasonic degassing 15min, dries 0.5h, room temperature curing 48h,
Back sheet is covered, with a thickness of 1.5mm, sealed package, room temperature preservation.
5. preparation method according to claim 1, which is characterized in that the matter of glycerol and ethylene glycol in the step 3.1
Amount is than being 4.5:1-5:1；It is 230-280r/min, mixing time 1-3min that revolving speed, which is mixed, in glycerol and ethylene glycol；EDTA
Mass ratio with glycerol is 0.01:1-0.01:1.5；The mass ratio of Dihydroxyaluminium Aminoacetate and glycerol is 1:48-2:48；EDTA and sweet is added
Hydroxyl aluminium stirs 3-8min respectively.
6. preparation method according to claim 5, which is characterized in that Sodium Polyacrylate, CMC-Na in the step 3.2
It is 12-15:3-8:1-5 with the mass ratio of PVPK30, the mass ratio of CMC-Na and Dihydroxyaluminium Aminoacetate is 1:0.1-1:0.5.
7. preparation method according to claim 5, which is characterized in that carbomer and distilled water in the step 3.3
Mass ratio is 0.2:15-0.6:15；Speed of agitator 280-320r/min, mixing time 25-35min, wherein carbomer with it is sweet
The mass ratio of hydroxyl aluminium is 5:3-10:3.
8. preparation method according to claim 5, which is characterized in that tartaric acid in the step 3.4 with it is kaolinic
Mass ratio is 1:3-3:3；The volume mass of pheretima syrup and tartaric acid ratio (ml/g) is 1:0.02-1:0.06；Nano silver colloidal sol
Volume mass ratio (ml/g) with tartaric acid is 1:0.1-1:0.15；Speed of agitator is 220-280r/min, mixing time 3-
The mass ratio of 8min, tartaric acid and Dihydroxyaluminium Aminoacetate is 2:5-6:5.
9. preparation method according to claim 5, which is characterized in that the speed of agitator 220-280r/ in the step 3.5
min。
10. the pheretima syrup nano silver water that preparation method described in any claim is prepared in a kind of claim 1-9
Gel adhesive.
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