CN101679466A - 对包括fpps、ggpps和dpps在内的多靶点效力提高的二膦酸盐化合物及方法 - Google Patents

对包括fpps、ggpps和dpps在内的多靶点效力提高的二膦酸盐化合物及方法 Download PDF

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CN101679466A
CN101679466A CN200880019104A CN200880019104A CN101679466A CN 101679466 A CN101679466 A CN 101679466A CN 200880019104 A CN200880019104 A CN 200880019104A CN 200880019104 A CN200880019104 A CN 200880019104A CN 101679466 A CN101679466 A CN 101679466A
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E·奥德菲尔德
张永辉
殷锋霖
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University of Illinois System
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    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • C07F9/3804—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)] not used, see subgroups
    • C07F9/3839—Polyphosphonic acids
    • C07F9/3878—Polyphosphonic acids containing substituents selected from B, Si, P (other than -PO3H2 groups) or a metal
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    • C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • C07F9/3804—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)] not used, see subgroups
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    • C07F9/3873—Polyphosphonic acids containing nitrogen substituent, e.g. N.....H or N-hydrocarbon group which can be substituted by halogen or nitro(so), N.....O, N.....S, N.....C(=X)- (X =O, S), N.....N, N...C(=X)...N (X =O, S)
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    • C07F9/65583—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system each of the hetero rings containing nitrogen as ring hetero atom
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CN200880019104A 2007-04-12 2008-04-11 对包括fpps、ggpps和dpps在内的多靶点效力提高的二膦酸盐化合物及方法 Pending CN101679466A (zh)

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US91142607P 2007-04-12 2007-04-12
US60/911,426 2007-04-12
PCT/US2008/060051 WO2008128056A1 (en) 2004-10-08 2008-04-11 Bisphosphonate compounds and methods with enhanced potency for multiple targets including fpps, ggpps, and dpps

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EP (1) EP2203460A4 (enrdf_load_stackoverflow)
JP (1) JP2010523709A (enrdf_load_stackoverflow)
CN (1) CN101679466A (enrdf_load_stackoverflow)
AU (1) AU2008240266A1 (enrdf_load_stackoverflow)
CA (1) CA2682694A1 (enrdf_load_stackoverflow)

Cited By (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102010905A (zh) * 2010-11-02 2011-04-13 山东省果树研究所 苹果fpps基因的三处突变及其鉴定方法
CN104822695A (zh) * 2012-07-05 2015-08-05 衣阿华大学研究基金会 治疗性双膦酸盐
CN108588023A (zh) * 2018-05-09 2018-09-28 河北森朗生物科技有限公司 一种生产嵌合抗原受体修饰的γδT细胞的方法
CN111569090A (zh) * 2016-01-15 2020-08-25 美国基因技术国际有限公司 用于活化γ-δ T细胞的方法和组合物
US11007209B2 (en) 2008-10-17 2021-05-18 American Gene Technologies International Inc. Safe lentiviral vectors for targeted delivery of multiple therapeutic molecules
US11090379B2 (en) 2016-07-08 2021-08-17 American Gene Technologies International Inc. HIV pre-immunization and immunotherapy
US11242527B1 (en) 2016-03-09 2022-02-08 American Gene Technologies International Inc. Combination vectors and methods for treating cancer
US11352646B2 (en) 2018-11-05 2022-06-07 American Gene Technologies International Inc. Vector system for expressing regulatory RNA
US11583562B2 (en) 2016-07-21 2023-02-21 American Gene Technologies International Inc. Viral vectors for treating Parkinson's disease
US11820999B2 (en) 2017-04-03 2023-11-21 American Gene Technologies International Inc. Compositions and methods for treating phenylketonuria
US11976292B2 (en) 2016-06-08 2024-05-07 American Gene Technologies International Inc. Non-integrating viral delivery system and methods related thereto
US11980663B2 (en) 2015-07-08 2024-05-14 American Gene Technologies International Inc. HIV pre-immunization and immunotherapy
US12090200B2 (en) 2016-02-08 2024-09-17 American Gene Technologies International Inc. Methods of producing cells resistant to HIV infection
US12403155B2 (en) 2016-01-15 2025-09-02 American Gene Technologies International Inc. Methods and compositions for the activation of gamma-delta T-cells
US12410445B2 (en) 2022-03-22 2025-09-09 American Gene Technologies International Inc. Vector system for expressing regulatory RNA

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2926081B1 (fr) * 2008-01-03 2010-02-19 Univ Nantes Derives d'acide hydroxy-bisphosphonique comme vecteur ciblant le tissu osseux
WO2014078957A1 (en) * 2012-11-20 2014-05-30 The Royal Institution For The Advancement Of Learning/Mcgill University Thienopyrimidine inhibitors of farnesyl and/or geranylgeranyl pyrophosphate synthase
JP6706799B2 (ja) 2014-12-19 2020-06-10 国立大学法人 長崎大学 新規ビスホスホン酸誘導体及びその用途
US10280188B2 (en) 2015-02-02 2019-05-07 Nagasaki University Fluorine-containing bisphosphonic acid derivative and use thereof

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20060079487A1 (en) * 2004-10-08 2006-04-13 The Board Of Trustees Of The University Of Illinois Bisphosphonate compounds and methods for bone resorption diseases, cancer, bone pain, immune disorders, and infectious diseases

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3623397A1 (de) * 1986-07-11 1988-01-14 Boehringer Mannheim Gmbh Neue diphosphonsaeurederivate, verfahren zu deren herstellung und diese verbindungen enthaltende arzneimittel
US5157027A (en) * 1991-05-13 1992-10-20 E. R. Squibb & Sons, Inc. Bisphosphonate squalene synthetase inhibitors and method
JPH05239075A (ja) * 1991-08-27 1993-09-17 Eisai Co Ltd 含リンイソプレノイド誘導体
TW222637B (enrdf_load_stackoverflow) * 1991-12-12 1994-04-21 Hoechst Ag
US5719303A (en) * 1993-03-08 1998-02-17 Eisai Co., Ltd. Phosphonic acid derivatives
US5728650A (en) * 1993-10-07 1998-03-17 Zeneca Limited Herbicidal aza bisphosphonic acids and compositions containing the same
WO1995034207A1 (en) * 1994-06-13 1995-12-21 Zeneca Limited Method of controlling plants by inhibition of farnesyl pyrophosphate synthase
WO2000052198A1 (en) * 1999-03-05 2000-09-08 Merck & Co., Inc. Methods for identifying compounds useful for inhibiting farnesyl diphosphate synthase
US20020004218A1 (en) * 2000-03-31 2002-01-10 Rodan Gideon A. Methods for identifying compounds useful for inhibiting geranylgeranyl diphosphate synthase
GB0019272D0 (en) * 2000-08-04 2000-09-27 Symphar Sa Pharmaceutical compounds
US6548042B2 (en) * 2000-08-07 2003-04-15 Arstad Erik Bis-phosphonate compounds
DE10114352C1 (de) * 2001-03-22 2002-04-18 Eucro Europe Contract Res Gmbh Verfahren zur Herstellung von 1-Hydroxy-1, 1-diphosphonsäureverbindungen
US20040206932A1 (en) * 2002-12-30 2004-10-21 Abuelyaman Ahmed S. Compositions including polymerizable bisphosphonic acids and methods
WO2005023270A2 (en) * 2003-09-09 2005-03-17 University Of Pittsburgh - Of The Commonwealth System Of Higher Education Compositions and methods for use of antiviral drugs in the treatment of retroviral diseases resistant to nucleoside reverse transcriptase inhibitors

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20060079487A1 (en) * 2004-10-08 2006-04-13 The Board Of Trustees Of The University Of Illinois Bisphosphonate compounds and methods for bone resorption diseases, cancer, bone pain, immune disorders, and infectious diseases

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
EVANGELIA KOTSIKOROU, ET AL.: "Bisphosphonate Inhibition of the Exopolyphosphatase Activity of theTrypanosoma brucei Soluble Vacuolar Pyrophosphatase", 《JOURNAL OF MEDICINAL CHEMISTRY》 *

Cited By (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11007209B2 (en) 2008-10-17 2021-05-18 American Gene Technologies International Inc. Safe lentiviral vectors for targeted delivery of multiple therapeutic molecules
CN102010905B (zh) * 2010-11-02 2013-05-01 山东省果树研究所 苹果fpps基因的三处突变及其鉴定方法
CN102010905A (zh) * 2010-11-02 2011-04-13 山东省果树研究所 苹果fpps基因的三处突变及其鉴定方法
CN104822695A (zh) * 2012-07-05 2015-08-05 衣阿华大学研究基金会 治疗性双膦酸盐
CN104822695B (zh) * 2012-07-05 2018-01-09 衣阿华大学研究基金会 治疗性双膦酸盐
US11980663B2 (en) 2015-07-08 2024-05-14 American Gene Technologies International Inc. HIV pre-immunization and immunotherapy
US11519006B2 (en) 2016-01-15 2022-12-06 American Gene Technologies International Inc. Methods and compositions for the activation of gamma-delta T-cells
US12403155B2 (en) 2016-01-15 2025-09-02 American Gene Technologies International Inc. Methods and compositions for the activation of gamma-delta T-cells
CN111569090A (zh) * 2016-01-15 2020-08-25 美国基因技术国际有限公司 用于活化γ-δ T细胞的方法和组合物
US12090200B2 (en) 2016-02-08 2024-09-17 American Gene Technologies International Inc. Methods of producing cells resistant to HIV infection
US11242527B1 (en) 2016-03-09 2022-02-08 American Gene Technologies International Inc. Combination vectors and methods for treating cancer
US12359203B2 (en) 2016-03-09 2025-07-15 American Gene Technologies International Inc. Combination vectors and methods for treating cancer
US11976292B2 (en) 2016-06-08 2024-05-07 American Gene Technologies International Inc. Non-integrating viral delivery system and methods related thereto
US11911458B2 (en) 2016-07-08 2024-02-27 American Gene Technologies International Inc. HIV pre-immunization and immunotherapy
US11090379B2 (en) 2016-07-08 2021-08-17 American Gene Technologies International Inc. HIV pre-immunization and immunotherapy
US12370253B2 (en) 2016-07-08 2025-07-29 American Gene Technologies International Inc. Pre-immunization and immunotherapy
US11583562B2 (en) 2016-07-21 2023-02-21 American Gene Technologies International Inc. Viral vectors for treating Parkinson's disease
US11820999B2 (en) 2017-04-03 2023-11-21 American Gene Technologies International Inc. Compositions and methods for treating phenylketonuria
CN108588023B (zh) * 2018-05-09 2020-02-14 河北森朗生物科技有限公司 一种生产嵌合抗原受体修饰的γδT细胞的方法
WO2019214290A1 (zh) * 2018-05-09 2019-11-14 河北森朗生物科技有限公司 一种生产嵌合抗原受体修饰的γδT细胞的方法
CN108588023A (zh) * 2018-05-09 2018-09-28 河北森朗生物科技有限公司 一种生产嵌合抗原受体修饰的γδT细胞的方法
US11352646B2 (en) 2018-11-05 2022-06-07 American Gene Technologies International Inc. Vector system for expressing regulatory RNA
US12410445B2 (en) 2022-03-22 2025-09-09 American Gene Technologies International Inc. Vector system for expressing regulatory RNA
US12410446B2 (en) 2022-11-01 2025-09-09 American Gene Technologies International Inc. Methods and compositions for the activation of gamma-delta T-cells

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