CA2682694A1 - Bisphosphonate compounds and methods with enhanced potency for multiple targets including fpps, ggpps, and dpps - Google Patents
Bisphosphonate compounds and methods with enhanced potency for multiple targets including fpps, ggpps, and dpps Download PDFInfo
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- CA2682694A1 CA2682694A1 CA002682694A CA2682694A CA2682694A1 CA 2682694 A1 CA2682694 A1 CA 2682694A1 CA 002682694 A CA002682694 A CA 002682694A CA 2682694 A CA2682694 A CA 2682694A CA 2682694 A1 CA2682694 A1 CA 2682694A1
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- 125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 description 1
- MPGGMSSLQRFXRP-DRLFUFNGSA-J tetrasodium;dioxido-oxo-[(6e,11e)-2,6,12,16-tetramethyl-9-phosphonatoheptadeca-2,6,11,15-tetraen-9-yl]-$l^{5}-phosphane Chemical compound [Na+].[Na+].[Na+].[Na+].CC(C)=CCC\C(C)=C\CC(P([O-])([O-])=O)(P([O-])([O-])=O)C\C=C(/C)CCC=C(C)C MPGGMSSLQRFXRP-DRLFUFNGSA-J 0.000 description 1
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Classifications
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- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
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- C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
- C07F9/3804—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)] not used, see subgroups
- C07F9/3839—Polyphosphonic acids
- C07F9/3878—Polyphosphonic acids containing substituents selected from B, Si, P (other than -PO3H2 groups) or a metal
-
- C—CHEMISTRY; METALLURGY
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- C07F9/3804—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)] not used, see subgroups
- C07F9/3839—Polyphosphonic acids
-
- C—CHEMISTRY; METALLURGY
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- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
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- C07F9/3804—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)] not used, see subgroups
- C07F9/3839—Polyphosphonic acids
- C07F9/3865—Polyphosphonic acids containing sulfur substituents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
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- C07F9/3873—Polyphosphonic acids containing nitrogen substituent, e.g. N.....H or N-hydrocarbon group which can be substituted by halogen or nitro(so), N.....O, N.....S, N.....C(=X)- (X =O, S), N.....N, N...C(=X)...N (X =O, S)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
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-
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- C07F9/576—Six-membered rings
- C07F9/58—Pyridine rings
-
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- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
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- C07F9/59—Hydrogenated pyridine rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
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- C07F9/6503—Five-membered rings
- C07F9/6506—Five-membered rings having the nitrogen atoms in positions 1 and 3
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- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
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- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6536—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having nitrogen and sulfur atoms with or without oxygen atoms, as the only ring hetero atoms
- C07F9/6539—Five-membered rings
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- C—CHEMISTRY; METALLURGY
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- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
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- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/655—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms
- C07F9/65515—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms the oxygen atom being part of a five-membered ring
- C07F9/65517—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms the oxygen atom being part of a five-membered ring condensed with carbocyclic rings or carbocyclic ring systems
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- C—CHEMISTRY; METALLURGY
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- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
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- C07F9/655345—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having sulfur atoms, with or without selenium or tellurium atoms, as the only ring hetero atoms the sulfur atom being part of a five-membered ring
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- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
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- C07F9/6558—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system
- C07F9/65583—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system each of the hetero rings containing nitrogen as ring hetero atom
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- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
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- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/66—Arsenic compounds
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- C07F9/72—Aliphatic compounds
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- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/48—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving transferase
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/90—Enzymes; Proenzymes
- G01N2333/91—Transferases (2.)
- G01N2333/9116—Transferases (2.) transferring alkyl or aryl groups other than methyl groups (2.5)
- G01N2333/91165—Transferases (2.) transferring alkyl or aryl groups other than methyl groups (2.5) general (2.5.1)
- G01N2333/91171—Transferases (2.) transferring alkyl or aryl groups other than methyl groups (2.5) general (2.5.1) with definite EC number (2.5.1.-)
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US91142607P | 2007-04-12 | 2007-04-12 | |
| US60/911,426 | 2007-04-12 | ||
| PCT/US2008/060051 WO2008128056A1 (en) | 2004-10-08 | 2008-04-11 | Bisphosphonate compounds and methods with enhanced potency for multiple targets including fpps, ggpps, and dpps |
Publications (1)
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| CA2682694A1 true CA2682694A1 (en) | 2008-10-23 |
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| CA002682694A Abandoned CA2682694A1 (en) | 2007-04-12 | 2008-04-11 | Bisphosphonate compounds and methods with enhanced potency for multiple targets including fpps, ggpps, and dpps |
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| EP (1) | EP2203460A4 (enrdf_load_stackoverflow) |
| JP (1) | JP2010523709A (enrdf_load_stackoverflow) |
| CN (1) | CN101679466A (enrdf_load_stackoverflow) |
| AU (1) | AU2008240266A1 (enrdf_load_stackoverflow) |
| CA (1) | CA2682694A1 (enrdf_load_stackoverflow) |
Cited By (1)
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|---|---|---|---|---|
| WO2014078957A1 (en) * | 2012-11-20 | 2014-05-30 | The Royal Institution For The Advancement Of Learning/Mcgill University | Thienopyrimidine inhibitors of farnesyl and/or geranylgeranyl pyrophosphate synthase |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| FR2926081B1 (fr) * | 2008-01-03 | 2010-02-19 | Univ Nantes | Derives d'acide hydroxy-bisphosphonique comme vecteur ciblant le tissu osseux |
| WO2010045659A1 (en) | 2008-10-17 | 2010-04-22 | American Gene Technologies International Inc. | Safe lentiviral vectors for targeted delivery of multiple therapeutic molecules |
| CN102010905B (zh) * | 2010-11-02 | 2013-05-01 | 山东省果树研究所 | 苹果fpps基因的三处突变及其鉴定方法 |
| EP2870168B1 (en) * | 2012-07-05 | 2016-11-23 | University of Iowa Research Foundation | Therapeutic bisphosphonates |
| JP6706799B2 (ja) | 2014-12-19 | 2020-06-10 | 国立大学法人 長崎大学 | 新規ビスホスホン酸誘導体及びその用途 |
| US10280188B2 (en) | 2015-02-02 | 2019-05-07 | Nagasaki University | Fluorine-containing bisphosphonic acid derivative and use thereof |
| JP6890831B2 (ja) | 2015-07-08 | 2021-06-18 | アメリカン ジーン テクノロジーズ インターナショナル インコーポレイテッド | Ｈｉｖ予備免疫化および免疫療法 |
| US10137144B2 (en) | 2016-01-15 | 2018-11-27 | American Gene Technologies International Inc. | Methods and compositions for the activation of gamma-delta T-cells |
| ES2965357T3 (es) * | 2016-01-15 | 2024-04-15 | American Gene Tech Int Inc | Métodos y composiciones para la activación de linfocitos T gamma-delta |
| US10888613B2 (en) | 2016-02-08 | 2021-01-12 | American Gene Technologies International Inc. | Method of producing cells resistant to HIV infection |
| JP7017247B2 (ja) | 2016-03-09 | 2022-02-08 | アメリカン ジーン テクノロジーズ インターナショナル インコーポレイテッド | がんを処置するための組み合わせベクターおよび方法 |
| EP3468617A4 (en) | 2016-06-08 | 2020-01-22 | American Gene Technologies International Inc. | INTEGRATED VIRAL ADMINISTRATION SYSTEM AND RELATED METHODS |
| JP6971492B2 (ja) | 2016-07-08 | 2021-11-24 | アメリカン ジーン テクノロジーズ インターナショナル インコーポレイテッド | Ｈｉｖ予備免疫化および免疫療法 |
| WO2018017882A1 (en) | 2016-07-21 | 2018-01-25 | American Gene Technologies International Inc. | Viral vectors for treating parkinson's disease |
| JP2020512815A (ja) | 2017-04-03 | 2020-04-30 | アメリカン ジーン テクノロジーズ インターナショナル インコーポレイテッド | フェニルケトン尿症を処置するための組成物および方法 |
| CN108588023B (zh) * | 2018-05-09 | 2020-02-14 | 河北森朗生物科技有限公司 | 一种生产嵌合抗原受体修饰的γδT细胞的方法 |
| US11352646B2 (en) | 2018-11-05 | 2022-06-07 | American Gene Technologies International Inc. | Vector system for expressing regulatory RNA |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3623397A1 (de) * | 1986-07-11 | 1988-01-14 | Boehringer Mannheim Gmbh | Neue diphosphonsaeurederivate, verfahren zu deren herstellung und diese verbindungen enthaltende arzneimittel |
| US5157027A (en) * | 1991-05-13 | 1992-10-20 | E. R. Squibb & Sons, Inc. | Bisphosphonate squalene synthetase inhibitors and method |
| JPH05239075A (ja) * | 1991-08-27 | 1993-09-17 | Eisai Co Ltd | 含リンイソプレノイド誘導体 |
| TW222637B (enrdf_load_stackoverflow) * | 1991-12-12 | 1994-04-21 | Hoechst Ag | |
| US5719303A (en) * | 1993-03-08 | 1998-02-17 | Eisai Co., Ltd. | Phosphonic acid derivatives |
| US5728650A (en) * | 1993-10-07 | 1998-03-17 | Zeneca Limited | Herbicidal aza bisphosphonic acids and compositions containing the same |
| WO1995034207A1 (en) * | 1994-06-13 | 1995-12-21 | Zeneca Limited | Method of controlling plants by inhibition of farnesyl pyrophosphate synthase |
| WO2000052198A1 (en) * | 1999-03-05 | 2000-09-08 | Merck & Co., Inc. | Methods for identifying compounds useful for inhibiting farnesyl diphosphate synthase |
| US20020004218A1 (en) * | 2000-03-31 | 2002-01-10 | Rodan Gideon A. | Methods for identifying compounds useful for inhibiting geranylgeranyl diphosphate synthase |
| GB0019272D0 (en) * | 2000-08-04 | 2000-09-27 | Symphar Sa | Pharmaceutical compounds |
| US6548042B2 (en) * | 2000-08-07 | 2003-04-15 | Arstad Erik | Bis-phosphonate compounds |
| DE10114352C1 (de) * | 2001-03-22 | 2002-04-18 | Eucro Europe Contract Res Gmbh | Verfahren zur Herstellung von 1-Hydroxy-1, 1-diphosphonsäureverbindungen |
| US20040206932A1 (en) * | 2002-12-30 | 2004-10-21 | Abuelyaman Ahmed S. | Compositions including polymerizable bisphosphonic acids and methods |
| WO2005023270A2 (en) * | 2003-09-09 | 2005-03-17 | University Of Pittsburgh - Of The Commonwealth System Of Higher Education | Compositions and methods for use of antiviral drugs in the treatment of retroviral diseases resistant to nucleoside reverse transcriptase inhibitors |
| US7358361B2 (en) * | 2004-10-08 | 2008-04-15 | The Board Of Trustees Of The University Of Illinois | Biophosphonate compounds and methods for bone resorption diseases, cancer, bone pain, immune disorders, and infectious diseases |
-
2008
- 2008-04-11 EP EP08780519A patent/EP2203460A4/en not_active Withdrawn
- 2008-04-11 JP JP2010503237A patent/JP2010523709A/ja active Pending
- 2008-04-11 CA CA002682694A patent/CA2682694A1/en not_active Abandoned
- 2008-04-11 CN CN200880019104A patent/CN101679466A/zh active Pending
- 2008-04-11 AU AU2008240266A patent/AU2008240266A1/en not_active Abandoned
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2014078957A1 (en) * | 2012-11-20 | 2014-05-30 | The Royal Institution For The Advancement Of Learning/Mcgill University | Thienopyrimidine inhibitors of farnesyl and/or geranylgeranyl pyrophosphate synthase |
Also Published As
| Publication number | Publication date |
|---|---|
| JP2010523709A (ja) | 2010-07-15 |
| EP2203460A4 (en) | 2012-03-14 |
| AU2008240266A1 (en) | 2008-10-23 |
| CN101679466A (zh) | 2010-03-24 |
| EP2203460A1 (en) | 2010-07-07 |
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