CN101679441B - 用于治疗丙型肝炎的化合物 - Google Patents
用于治疗丙型肝炎的化合物 Download PDFInfo
- Publication number
- CN101679441B CN101679441B CN200880016128XA CN200880016128A CN101679441B CN 101679441 B CN101679441 B CN 101679441B CN 200880016128X A CN200880016128X A CN 200880016128XA CN 200880016128 A CN200880016128 A CN 200880016128A CN 101679441 B CN101679441 B CN 101679441B
- Authority
- CN
- China
- Prior art keywords
- hcv
- compound
- cyclohexyl
- alkyl
- mmol
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- IZPUCLUAOJYRDR-UHFFFAOYSA-N CN(C)S(NC(c1ccc(c(C2CCCCC2)c(-c(cc2)c(C3C4)cc2OC)[n]2CC34C(O)=O)c2c1)=O)(=O)=O Chemical compound CN(C)S(NC(c1ccc(c(C2CCCCC2)c(-c(cc2)c(C3C4)cc2OC)[n]2CC34C(O)=O)c2c1)=O)(=O)=O IZPUCLUAOJYRDR-UHFFFAOYSA-N 0.000 description 1
- DJMPPRZIHRHKIL-UHFFFAOYSA-N CN(C)S(NC(c1ccc(c(C2CCCCC2)c(-c(cc2)c(C3C4)cc2OC)[n]2CC34C(OC)=O)c2c1)=O)(=O)=O Chemical compound CN(C)S(NC(c1ccc(c(C2CCCCC2)c(-c(cc2)c(C3C4)cc2OC)[n]2CC34C(OC)=O)c2c1)=O)(=O)=O DJMPPRZIHRHKIL-UHFFFAOYSA-N 0.000 description 1
- IWWRLUKIKYDKKQ-UHFFFAOYSA-N CN(C)S(NC(c1ccc(c(C2CCCCC2)c-2[n]3CC(COC(N4CCOCC4)=O)(C4)C4c4c-2ccc(OC)c4)c3c1)=O)(=O)=O Chemical compound CN(C)S(NC(c1ccc(c(C2CCCCC2)c-2[n]3CC(COC(N4CCOCC4)=O)(C4)C4c4c-2ccc(OC)c4)c3c1)=O)(=O)=O IWWRLUKIKYDKKQ-UHFFFAOYSA-N 0.000 description 1
- 0 COc(cc1)cc2c1-c1c(C3CCCCC3)c(ccc(C(NS(*)(=O)=O)=O)c3)c3[n]1CC1(COC(**)=O)C2C1 Chemical compound COc(cc1)cc2c1-c1c(C3CCCCC3)c(ccc(C(NS(*)(=O)=O)=O)c3)c3[n]1CC1(COC(**)=O)C2C1 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Communicable Diseases (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Oncology (AREA)
- Veterinary Medicine (AREA)
- Virology (AREA)
- Molecular Biology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Steroid Compounds (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US89499907P | 2007-03-15 | 2007-03-15 | |
| US60/894,999 | 2007-03-15 | ||
| PCT/US2008/056807 WO2008112863A1 (en) | 2007-03-15 | 2008-03-13 | Compounds for the treatment of hepatitis c |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN101679441A CN101679441A (zh) | 2010-03-24 |
| CN101679441B true CN101679441B (zh) | 2012-11-14 |
Family
ID=39522038
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN200880016128XA Expired - Fee Related CN101679441B (zh) | 2007-03-15 | 2008-03-13 | 用于治疗丙型肝炎的化合物 |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US7538103B2 (enExample) |
| EP (1) | EP2121696B1 (enExample) |
| JP (1) | JP5343011B2 (enExample) |
| CN (1) | CN101679441B (enExample) |
| AT (1) | ATE494291T1 (enExample) |
| DE (1) | DE602008004317D1 (enExample) |
| ES (1) | ES2357076T3 (enExample) |
| WO (1) | WO2008112863A1 (enExample) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1688420A4 (en) * | 2003-11-19 | 2008-10-22 | Japan Tobacco Inc | 5-5 LOW-CONDENSED HETEROCYCLIC COMPOUND AND THEIR USE AS HCV POLYMERASE INHIBITOR |
| US20070049593A1 (en) * | 2004-02-24 | 2007-03-01 | Japan Tobacco Inc. | Tetracyclic fused heterocyclic compound and use thereof as HCV polymerase inhibitor |
| US7659263B2 (en) | 2004-11-12 | 2010-02-09 | Japan Tobacco Inc. | Thienopyrrole compound and use thereof as HCV polymerase inhibitor |
| US7521443B2 (en) * | 2006-05-17 | 2009-04-21 | Bristol-Myers Squibb Company | Cyclopropyl fused indolobenzazepine HCV NS5B inhibitors |
| US7652004B2 (en) * | 2007-08-09 | 2010-01-26 | Bristol-Myers Squibb Company | Compounds for the treatment of hepatitis C |
| US7642251B2 (en) * | 2007-08-09 | 2010-01-05 | Bristol-Myers Squibb Company | Compounds for the treatment of hepatitis C |
| US8143243B2 (en) * | 2007-08-09 | 2012-03-27 | Bristol-Myers Squibb Company | Compounds for the treatment of hepatitis C |
| US8129367B2 (en) * | 2007-11-21 | 2012-03-06 | Bristol-Myers Squibb Company | Compounds for the treatment of Hepatitis C |
| US8124601B2 (en) * | 2007-11-21 | 2012-02-28 | Bristol-Myers Squibb Company | Compounds for the treatment of Hepatitis C |
| US8138171B2 (en) * | 2008-03-27 | 2012-03-20 | Bristol-Myers Squibb Company | Dioxolane and dioxolanone fused indolobenzadiazepine HCV NS5B inhibitors |
| EP2280978B1 (en) * | 2008-03-27 | 2013-04-24 | Bristol-Myers Squibb Company | Pyrrolidine fused indolobenzadiazepine hcv ns5b inhibitors |
| US8178523B2 (en) * | 2008-03-27 | 2012-05-15 | Bristol-Myers Squibb Company | Compounds for the treatment of hepatitis C |
| US8133884B2 (en) * | 2008-05-06 | 2012-03-13 | Bristol-Myers Squibb Company | Compounds for the treatment of hepatitis C |
| US8143244B2 (en) * | 2009-02-26 | 2012-03-27 | Bristol-Myers Squibb Company | Cyclopropyl fused indolobenzazepine HCV NS5B inhibitors |
| US12274700B1 (en) | 2020-10-30 | 2025-04-15 | Accencio LLC | Methods of treating symptoms of coronavirus infection with RNA polymerase inhibitors |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1466591A (zh) * | 2000-08-30 | 2004-01-07 | - | 核苷衍生物 |
| WO2006020082A1 (en) * | 2004-08-09 | 2006-02-23 | Bristol-Myers Squibb Company | Inhibitors of hcv replication |
| WO2006029912A1 (en) * | 2004-06-11 | 2006-03-23 | Istituto Di Ricerche Di Biologia Molecolare P. Angeletti Spa | Indole derivatives as antiviral agents |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE602005013922D1 (de) | 2004-02-24 | 2009-05-28 | Japan Tobacco Inc | Kondensierte heterotetracyclische verbindungen und deren verwendung als hcv-polymerase-inhibitor |
| US7348425B2 (en) | 2004-08-09 | 2008-03-25 | Bristol-Myers Squibb Company | Inhibitors of HCV replication |
| AU2005298403A1 (en) | 2004-10-26 | 2006-05-04 | Istituto Di Ricerche Di Biologia Molecolare P Angeletti Spa | Tetracyclic indole derivatives as antiviral agents |
| GB0518390D0 (en) | 2005-09-09 | 2005-10-19 | Angeletti P Ist Richerche Bio | Therapeutic compounds |
| US7399758B2 (en) * | 2005-09-12 | 2008-07-15 | Meanwell Nicholas A | Cyclopropyl fused indolobenzazepine HCV NS5B inhibitors |
| US7473688B2 (en) | 2005-09-13 | 2009-01-06 | Bristol-Myers Squibb Company | Indolobenzazepine HCV NS5B inhibitors |
| US7456165B2 (en) | 2006-02-08 | 2008-11-25 | Bristol-Myers Squibb Company | HCV NS5B inhibitors |
| GB0608928D0 (en) | 2006-05-08 | 2006-06-14 | Angeletti P Ist Richerche Bio | Therapeutic agents |
| US7456166B2 (en) | 2006-05-17 | 2008-11-25 | Bristol-Myers Squibb Company | Cyclopropyl fused indolobenzazepine HCV NS5B inhibitors |
| US7521441B2 (en) | 2006-05-22 | 2009-04-21 | Bristol-Myers Squibb Company | Cyclopropyl fused indolobenzazepine HCV NS5B inhibitors |
| US7521442B2 (en) | 2006-05-25 | 2009-04-21 | Bristol-Myers Squibb Company | Cyclopropyl fused indolobenzazepine HCV NS5B inhibitors |
| CN101490054B (zh) | 2006-05-25 | 2012-05-16 | 百时美施贵宝公司 | 环丙基稠合的吲哚并苯并氮杂*hcv ns5b抑制剂 |
| US7452876B2 (en) | 2006-06-08 | 2008-11-18 | Bristol-Myers Squibb Company | Cyclopropyl fused indolobenzazepine HCV NS5B inhibitors |
| EP2121707B1 (en) * | 2006-12-20 | 2012-12-05 | Istituto di Ricerche di Biologia Molecolare P. Angeletti S.R.L. | Antiviral indoles |
-
2008
- 2008-03-11 US US12/046,286 patent/US7538103B2/en active Active
- 2008-03-13 JP JP2009553770A patent/JP5343011B2/ja not_active Expired - Fee Related
- 2008-03-13 WO PCT/US2008/056807 patent/WO2008112863A1/en not_active Ceased
- 2008-03-13 AT AT08732099T patent/ATE494291T1/de not_active IP Right Cessation
- 2008-03-13 CN CN200880016128XA patent/CN101679441B/zh not_active Expired - Fee Related
- 2008-03-13 DE DE602008004317T patent/DE602008004317D1/de active Active
- 2008-03-13 EP EP08732099A patent/EP2121696B1/en not_active Not-in-force
- 2008-03-13 ES ES08732099T patent/ES2357076T3/es active Active
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1466591A (zh) * | 2000-08-30 | 2004-01-07 | - | 核苷衍生物 |
| WO2006029912A1 (en) * | 2004-06-11 | 2006-03-23 | Istituto Di Ricerche Di Biologia Molecolare P. Angeletti Spa | Indole derivatives as antiviral agents |
| WO2006020082A1 (en) * | 2004-08-09 | 2006-02-23 | Bristol-Myers Squibb Company | Inhibitors of hcv replication |
Also Published As
| Publication number | Publication date |
|---|---|
| ES2357076T3 (es) | 2011-04-18 |
| WO2008112863A1 (en) | 2008-09-18 |
| ATE494291T1 (de) | 2011-01-15 |
| US20080226593A1 (en) | 2008-09-18 |
| CN101679441A (zh) | 2010-03-24 |
| US7538103B2 (en) | 2009-05-26 |
| EP2121696B1 (en) | 2011-01-05 |
| EP2121696A1 (en) | 2009-11-25 |
| DE602008004317D1 (de) | 2011-02-17 |
| JP2010521484A (ja) | 2010-06-24 |
| JP5343011B2 (ja) | 2013-11-13 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20121114 Termination date: 20150313 |
|
| EXPY | Termination of patent right or utility model |