CN101679318A - 使用链接化学法的用于碳酸酐酶-ix的分子成象探针的发展 - Google Patents

使用链接化学法的用于碳酸酐酶-ix的分子成象探针的发展 Download PDF

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CN101679318A
CN101679318A CN200880010576A CN200880010576A CN101679318A CN 101679318 A CN101679318 A CN 101679318A CN 200880010576 A CN200880010576 A CN 200880010576A CN 200880010576 A CN200880010576 A CN 200880010576A CN 101679318 A CN101679318 A CN 101679318A
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methyl
alkyl
triazol
phenyl
yloxy
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Chinese (zh)
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H·C·科尔布
J·C·沃什
D·卡西
V·莫查拉
王兵
U·B·甘达哈马斯
B·A·杜克洛斯
陈凯
张炜
陈钢
H·C·帕吉特
F·卡里米
P·J·H·斯科特
高志勇
梁千瓦
T·L·柯利耶
赵铁铭
夏春芳
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Siemens Medical Solutions USA Inc
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CN200880010576A 2007-04-05 2008-04-07 使用链接化学法的用于碳酸酐酶-ix的分子成象探针的发展 Pending CN101679318A (zh)

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US92206507P 2007-04-05 2007-04-05
US60/922,065 2007-04-05
PCT/US2008/059599 WO2008124703A2 (en) 2007-04-05 2008-04-07 Development of molecular imaging probes for carbonic anhydrase-ix using click chemistry

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US (2) US7829063B2 (enExample)
EP (2) EP2468734A1 (enExample)
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CN (1) CN101679318A (enExample)
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Cited By (10)

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CN102219753A (zh) * 2011-04-21 2011-10-19 山东大学 一种三氮唑类化合物及其制备方法与应用
CN103380118A (zh) * 2010-10-29 2013-10-30 克林诺株式会社 Tau成像探针
CN104212440A (zh) * 2014-09-03 2014-12-17 无锡艾德美特生物科技有限公司 一类喹唑啉类荧光探针及其制备和应用
CN105541825A (zh) * 2015-12-28 2016-05-04 中国药科大学 三氮唑衍生物制备方法及其作为药物的用途
CN106243051A (zh) * 2010-11-13 2016-12-21 茵库恩制药有限公司 金属酶抑制剂化合物
CN107428776A (zh) * 2015-03-24 2017-12-01 H.隆德贝克有限公司 制造4,5,6,7‑四氢异噁唑并[5,4‑c]吡啶‑3‑醇
CN109476655A (zh) * 2016-05-13 2019-03-15 约翰霍普金斯大学 靶向碳酸酐酶ix的核成像剂和放射治疗剂及其用途
CN110997651A (zh) * 2017-08-17 2020-04-10 葛兰素史密斯克莱知识产权发展有限公司 新的四唑化合物和它们在治疗结核病中的用途
CN117986213A (zh) * 2024-02-26 2024-05-07 厦门大学 一种5-氯甲基糠醛制备2,5-二（氨基甲基）呋喃的方法
WO2025113696A1 (zh) * 2023-11-30 2025-06-05 赣州和美药业股份有限公司 一种化合物及其应用

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MX2010004880A (es) * 2007-10-29 2010-07-28 Schering Corp Derivados heterociclicos de urea y tiourea, y metodos de uso de los mismos.
CN102083427B (zh) * 2008-01-09 2014-12-10 分子洞察制药公司 碳酸酐酶ix的抑制剂
WO2010065899A2 (en) 2008-12-05 2010-06-10 Molecular Insight Pharmaceuticals, Inc. Technetium-and rhenium-bis(heteroaryl)complexes and methods of use thereof
WO2010077613A1 (en) 2008-12-09 2010-07-08 Gilead Sciences, Inc. Modulators of toll-like receptors
US8465725B2 (en) 2009-06-15 2013-06-18 Molecular Insight Pharmaceuticlas, Inc. Process for production of heterodimers of glutamic acid
US9914745B2 (en) 2009-08-14 2018-03-13 Indian Association For The Cultivation Of Science Morpholino-based antisense agent
US20120263714A1 (en) * 2009-10-21 2012-10-18 Bayer Intellectual Property Gmbh Substituted halophenoxybenzamide derivatives
EP2556372A1 (en) * 2010-04-08 2013-02-13 Siemens Medical Solutions USA, Inc. Synthesis of 18f-labeled tracers in hydrous organic solvents
US10639608B2 (en) 2010-04-08 2020-05-05 Siemens Medical Solutions Usa, Inc. System, device and method for preparing tracers and transferring materials during radiosynthesis
WO2012118715A2 (en) * 2011-02-28 2012-09-07 The Board Of Trustees Of Leland Stanford Junior University Non-peptidic quenched fluorescent imaging probes
CN103687854A (zh) 2011-05-09 2014-03-26 文森医学公司 碳酸酐酶靶向剂及其使用方法
JP2014156400A (ja) * 2011-05-24 2014-08-28 Astellas Pharma Inc 腫瘍の画像診断用標識誘導体
CA2860504A1 (en) 2012-01-06 2013-07-11 Molecular Insight Pharmaceuticals Metal complexes of poly(carboxyl)amine-containing ligands having an affinity for carbonic anhydrase ix
CN114042171B (zh) 2012-03-30 2024-12-06 文森医学公司 细菌成像剂及其使用方法
CA2897437C (en) 2013-01-14 2021-12-14 Molecular Insight Pharmaceuticals, Inc. Triazine based radiopharmaceuticals and radioimaging agents
AR098311A1 (es) 2013-11-05 2016-05-26 Bayer Cropscience Ag Compuestos para el control de artrópodos
EP4140485A1 (en) 2014-07-11 2023-03-01 Gilead Sciences, Inc. Modulators of toll-like receptors for the treatment of hiv
EA201790369A1 (ru) 2014-09-16 2017-10-31 Джилид Сайэнс, Инк. Твердые формы модулятора толл-подобного рецептора
JP6373490B2 (ja) * 2014-09-16 2018-08-15 ギリアード サイエンシーズ， インコーポレイテッド Ｔｏｌｌ様受容体モジュレーターを調製する方法
LT6401B (lt) 2015-07-28 2017-06-12 Vilniaus Universitetas Karboanhidrazės selektyvūs inhibitoriai
US10695450B2 (en) 2016-07-26 2020-06-30 Laboratoires Cyclopharma Synthesis of a radioactive agent composition
CN110785414A (zh) * 2017-04-20 2020-02-11 加利福尼亚大学董事会 K-Ras调节剂
KR102147971B1 (ko) * 2019-11-22 2020-08-25 국방과학연구소 반응용매에 대한 혼화성 차이를 이용한 화학선택적 트리아졸의 제조방법

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US6562319B2 (en) * 2001-03-12 2003-05-13 Yissum Research Development Company Of The Hebrew University Of Jerusalem Radiolabeled irreversible inhibitors of epidermal growth factor receptor tyrosine kinase and their use in radioimaging and radiotherapy
AU2003295950B2 (en) * 2002-11-26 2007-06-28 Institute Of Virology CA IX-specific inhibitors
CA2606477C (en) 2005-04-27 2013-05-28 Siemens Medical Solutions Usa, Inc. In situ click chemistry method for screening high affinity molecular imaging probes
EP1733742A1 (en) 2005-06-17 2006-12-20 Universiteit Utrecht Holding B.V. Dendrimers multivalently substituted with active groups
CA2617907A1 (en) 2005-08-05 2007-02-15 Syntarga B.V. Triazole-containing releasable linkers and conjugates comprising the same
WO2008027162A2 (en) * 2006-08-28 2008-03-06 The Trustees Of The University Of Pennsylvania 129xe biosensors and their use
US20080213175A1 (en) 2006-09-15 2008-09-04 Kolb Hartmuth C Click chemistry-derived cyclic peptidomimetics as integrin markers

Cited By (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103380118A (zh) * 2010-10-29 2013-10-30 克林诺株式会社 Tau成像探针
CN106243051B (zh) * 2010-11-13 2019-03-08 茵库恩制药有限公司 金属酶抑制剂化合物
CN106243051A (zh) * 2010-11-13 2016-12-21 茵库恩制药有限公司 金属酶抑制剂化合物
CN102219753A (zh) * 2011-04-21 2011-10-19 山东大学 一种三氮唑类化合物及其制备方法与应用
CN104212440A (zh) * 2014-09-03 2014-12-17 无锡艾德美特生物科技有限公司 一类喹唑啉类荧光探针及其制备和应用
CN104212440B (zh) * 2014-09-03 2016-03-30 无锡艾德美特生物科技有限公司 一类喹唑啉类荧光探针及其制备和应用
CN107428776A (zh) * 2015-03-24 2017-12-01 H.隆德贝克有限公司 制造4,5,6,7‑四氢异噁唑并[5,4‑c]吡啶‑3‑醇
CN105541825A (zh) * 2015-12-28 2016-05-04 中国药科大学 三氮唑衍生物制备方法及其作为药物的用途
CN109476655A (zh) * 2016-05-13 2019-03-15 约翰霍普金斯大学 靶向碳酸酐酶ix的核成像剂和放射治疗剂及其用途
CN110997651A (zh) * 2017-08-17 2020-04-10 葛兰素史密斯克莱知识产权发展有限公司 新的四唑化合物和它们在治疗结核病中的用途
CN110997651B (zh) * 2017-08-17 2023-01-03 葛兰素史密斯克莱知识产权发展有限公司 新的四唑化合物和它们在治疗结核病中的用途
WO2025113696A1 (zh) * 2023-11-30 2025-06-05 赣州和美药业股份有限公司 一种化合物及其应用
CN117986213A (zh) * 2024-02-26 2024-05-07 厦门大学 一种5-氯甲基糠醛制备2,5-二（氨基甲基）呋喃的方法

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KR20090127433A (ko) 2009-12-11
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WO2008124703A2 (en) 2008-10-16
US20090123372A1 (en) 2009-05-14
US8354092B2 (en) 2013-01-15
WO2008124703A3 (en) 2009-02-05
CA2683434A1 (en) 2008-10-16
EP2468734A1 (en) 2012-06-27
US20100317842A1 (en) 2010-12-16
JP2010523599A (ja) 2010-07-15
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