CN101679237A - 制备(r)-2-甲基吡咯烷和(s)-2-甲基吡咯烷及其酒石酸盐的方法 - Google Patents

制备(r)-2-甲基吡咯烷和(s)-2-甲基吡咯烷及其酒石酸盐的方法 Download PDF

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Publication number
CN101679237A
CN101679237A CN200880021225A CN200880021225A CN101679237A CN 101679237 A CN101679237 A CN 101679237A CN 200880021225 A CN200880021225 A CN 200880021225A CN 200880021225 A CN200880021225 A CN 200880021225A CN 101679237 A CN101679237 A CN 101679237A
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CN
China
Prior art keywords
methylpyrrolidine
methyl
tartrate
phenyl
pyrrolidin
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN200880021225A
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English (en)
Chinese (zh)
Inventor
迈克尔·克里斯蒂
约瑟夫·J·佩特雷蒂斯
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Cephalon LLC
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Cephalon LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cephalon LLC filed Critical Cephalon LLC
Publication of CN101679237A publication Critical patent/CN101679237A/zh
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/06—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with radicals, containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Catalysts (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Cosmetics (AREA)
CN200880021225A 2007-05-03 2008-05-02 制备(r)-2-甲基吡咯烷和(s)-2-甲基吡咯烷及其酒石酸盐的方法 Pending CN101679237A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US92735607P 2007-05-03 2007-05-03
US60/927,356 2007-05-03
PCT/US2008/005702 WO2008137087A1 (en) 2007-05-03 2008-05-02 Processes for preparing (r)-2-methylpyrrolidine and (s)-2-methylpyrrolidine and tartrate salts thereof

Publications (1)

Publication Number Publication Date
CN101679237A true CN101679237A (zh) 2010-03-24

Family

ID=39688886

Family Applications (1)

Application Number Title Priority Date Filing Date
CN200880021225A Pending CN101679237A (zh) 2007-05-03 2008-05-02 制备(r)-2-甲基吡咯烷和(s)-2-甲基吡咯烷及其酒石酸盐的方法

Country Status (14)

Country Link
EP (1) EP2152669A1 (https=)
JP (1) JP5698887B2 (https=)
KR (1) KR20100017565A (https=)
CN (1) CN101679237A (https=)
AU (1) AU2008248168B2 (https=)
BR (1) BRPI0810330A2 (https=)
CA (1) CA2686033A1 (https=)
EA (1) EA019031B1 (https=)
IL (1) IL201627A (https=)
MX (1) MX2009011787A (https=)
NZ (1) NZ580948A (https=)
UA (1) UA99913C2 (https=)
WO (1) WO2008137087A1 (https=)
ZA (1) ZA200907643B (https=)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN112638869A (zh) * 2018-09-07 2021-04-09 赛诺菲 6-(2,4-二氯苯基)-5-[4-[(3s)-1-(3-氟丙基)吡咯烷-3-基]氧基苯基]-8,9-二氢-7h-苯并[7]轮烯-2-甲酸甲酯的盐及其制备方法

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Publication number Priority date Publication date Assignee Title
UA95644C2 (ru) 2006-07-25 2011-08-25 Сефалон, Инк. Пиридазиноновые производные, фармацевтическая композиция и способ лечения заболеваний
US8383657B2 (en) 2007-12-21 2013-02-26 Abbott Laboratories Thiazolylidine urea and amide derivatives and methods of use thereof
CA2712885A1 (en) * 2008-01-30 2009-08-06 Cephalon, Inc. Substituted pyridazine derivatives which have histamine h3 antagonist activity
EP3237408B1 (en) * 2014-12-23 2018-10-31 Cephalon, Inc. Methods for preparing fused bicyclic 2, 4-diaminopyrimidine derivatives

Citations (1)

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WO2008013838A2 (en) * 2006-07-25 2008-01-31 Cephalon, Inc. Pyridizinone derivatives

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FR2714849B1 (fr) 1994-01-13 1996-04-05 Inst Francais Du Petrole Procédé de préparation d'un catalyseur d'hydrogénation soluble en phase liquide organique.
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WO2007099423A1 (en) 2006-03-02 2007-09-07 Pfizer Products Inc. 1-pyrrolidine indane derivatives as histamine-3 receptor antagonists
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Publication number Priority date Publication date Assignee Title
WO2008013838A2 (en) * 2006-07-25 2008-01-31 Cephalon, Inc. Pyridizinone derivatives

Non-Patent Citations (1)

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Title
LUCIA A. VAN DE KUILL 等: "Organonickel(II) complexes containing aryl ligands with chiral pyrrolidinyl ring systems; syntheses and use as homogeneous catalysts for the Kharasch addition reaction", 《RECUEIL DES TRAVAUX CHIMIQUES DES PAY-BAS》 *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN112638869A (zh) * 2018-09-07 2021-04-09 赛诺菲 6-(2,4-二氯苯基)-5-[4-[(3s)-1-(3-氟丙基)吡咯烷-3-基]氧基苯基]-8,9-二氢-7h-苯并[7]轮烯-2-甲酸甲酯的盐及其制备方法

Also Published As

Publication number Publication date
JP5698887B2 (ja) 2015-04-08
UA99913C2 (ru) 2012-10-25
EA019031B1 (ru) 2013-12-30
CA2686033A1 (en) 2008-11-13
EP2152669A1 (en) 2010-02-17
IL201627A0 (en) 2010-05-31
ZA200907643B (en) 2014-03-26
MX2009011787A (es) 2009-11-13
NZ580948A (en) 2011-04-29
AU2008248168B2 (en) 2013-03-21
KR20100017565A (ko) 2010-02-16
BRPI0810330A2 (pt) 2014-10-14
WO2008137087A1 (en) 2008-11-13
EA200971019A1 (ru) 2010-04-30
JP2010526142A (ja) 2010-07-29
IL201627A (en) 2014-06-30
AU2008248168A1 (en) 2008-11-13

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Application publication date: 20100324