CN101679235A - 氮杂环丁烷衍生物和它们作为前列腺素e2拮抗剂的用途 - Google Patents

氮杂环丁烷衍生物和它们作为前列腺素e2拮抗剂的用途 Download PDF

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Publication number
CN101679235A
CN101679235A CN200880019555A CN200880019555A CN101679235A CN 101679235 A CN101679235 A CN 101679235A CN 200880019555 A CN200880019555 A CN 200880019555A CN 200880019555 A CN200880019555 A CN 200880019555A CN 101679235 A CN101679235 A CN 101679235A
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CN
China
Prior art keywords
compound
prodrug
solvate
compounds
mmol
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Pending
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CN200880019555A
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English (en)
Chinese (zh)
Inventor
K·N·达克
S·K·耶普
S·E·斯凯拉特
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Pfizer Ltd
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Pfizer Ltd
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Application filed by Pfizer Ltd filed Critical Pfizer Ltd
Publication of CN101679235A publication Critical patent/CN101679235A/zh
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
    • C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
    • C07D205/04—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/397—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having four-membered rings, e.g. azetidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Reproductive Health (AREA)
  • Endocrinology (AREA)
  • Pulmonology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Gynecology & Obstetrics (AREA)
  • Pregnancy & Childbirth (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
CN200880019555A 2007-05-10 2008-04-28 氮杂环丁烷衍生物和它们作为前列腺素e2拮抗剂的用途 Pending CN101679235A (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US91708107P 2007-05-10 2007-05-10
US60/917,081 2007-05-10
US1303007P 2007-12-12 2007-12-12
US61/013,030 2007-12-12
PCT/IB2008/001070 WO2008139287A1 (en) 2007-05-10 2008-04-28 Azetidine derivatives and their use as prostaglandin e2 antagonists

Publications (1)

Publication Number Publication Date
CN101679235A true CN101679235A (zh) 2010-03-24

Family

ID=39739736

Family Applications (1)

Application Number Title Priority Date Filing Date
CN200880019555A Pending CN101679235A (zh) 2007-05-10 2008-04-28 氮杂环丁烷衍生物和它们作为前列腺素e2拮抗剂的用途

Country Status (27)

Country Link
US (1) US20080280877A1 (cg-RX-API-DMAC10.html)
EP (1) EP2155666A1 (cg-RX-API-DMAC10.html)
JP (1) JP2010526801A (cg-RX-API-DMAC10.html)
KR (1) KR20100009582A (cg-RX-API-DMAC10.html)
CN (1) CN101679235A (cg-RX-API-DMAC10.html)
AP (1) AP2009005047A0 (cg-RX-API-DMAC10.html)
AR (1) AR066524A1 (cg-RX-API-DMAC10.html)
AU (1) AU2008249744A1 (cg-RX-API-DMAC10.html)
BR (1) BRPI0811444A2 (cg-RX-API-DMAC10.html)
CA (1) CA2686517A1 (cg-RX-API-DMAC10.html)
CL (1) CL2008001305A1 (cg-RX-API-DMAC10.html)
CO (1) CO6260066A2 (cg-RX-API-DMAC10.html)
CR (1) CR11101A (cg-RX-API-DMAC10.html)
DO (1) DOP2009000256A (cg-RX-API-DMAC10.html)
EA (1) EA200901381A1 (cg-RX-API-DMAC10.html)
EC (1) ECSP099727A (cg-RX-API-DMAC10.html)
GT (1) GT200900293A (cg-RX-API-DMAC10.html)
IL (1) IL201874A0 (cg-RX-API-DMAC10.html)
MA (1) MA31366B1 (cg-RX-API-DMAC10.html)
MX (1) MX2009011998A (cg-RX-API-DMAC10.html)
PA (1) PA8779601A1 (cg-RX-API-DMAC10.html)
PE (1) PE20090282A1 (cg-RX-API-DMAC10.html)
SV (1) SV2009003407A (cg-RX-API-DMAC10.html)
TN (1) TN2009000470A1 (cg-RX-API-DMAC10.html)
TW (1) TW200904409A (cg-RX-API-DMAC10.html)
UY (1) UY31070A1 (cg-RX-API-DMAC10.html)
WO (1) WO2008139287A1 (cg-RX-API-DMAC10.html)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102448965A (zh) * 2009-04-02 2012-05-09 阿勒根公司 前列腺素e受体拮抗剂
CN110041269A (zh) * 2019-05-16 2019-07-23 海门瑞一医药科技有限公司 一种2-氯-5-羟基嘧啶的制备方法

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20100256109A1 (en) * 2007-11-15 2010-10-07 Sarah Elizabeth Skerratt Azetidines As EP2 Antagonists
PE20110663A1 (es) * 2008-11-10 2011-09-23 Pfizer Ltd Pirrolidinas
DE102009049662A1 (de) 2009-10-13 2011-04-14 Bayer Schering Pharma Aktiengesellschaft 2,5-Disubstituierte 2H-Indazole als EP2-Rezeptor-Antagonisten
WO2013010679A1 (en) 2011-07-15 2013-01-24 Novartis Ag Salts of aza-bicyclic di-aryl ethers and methods to make them or their precursors
TW201326154A (zh) 2011-11-28 2013-07-01 拜耳知識產權公司 作為ｅｐ２受體拮抗劑之新穎２ｈ－吲唑
EP3237401B1 (en) 2014-12-22 2019-03-06 Pfizer Inc Antagonists of prostaglandin ep3 receptor
US12703680B2 (en) 2019-11-21 2026-08-11 University Of Utah Research Foundation TRPV4 receptor ligands
JP2024524986A (ja) 2021-06-24 2024-07-09 レザボア ニューロサイエンス，インコーポレイテッド Ｅｐ２アンタゴニスト化合物
EP4359399A4 (en) * 2021-06-24 2025-04-23 Reservoir Neuroscience, Inc. EP2 antagonist compounds

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8300860D0 (en) * 1983-01-13 1983-02-16 Shell Int Research Azetidine compounds
GB8415614D0 (en) * 1984-06-19 1984-07-25 Shell Int Research Azetidine derivatives
GB8509746D0 (en) * 1985-04-16 1985-05-22 Shell Int Research Preparing azetidine derivatives
AR037364A1 (es) 2001-11-16 2004-11-03 Schering Corp Azetidinil diaminas utiles como ligandos del receptor de nociceptina orl-1
NZ567140A (en) * 2005-10-07 2011-09-30 Exelixis Inc Azetidines as MEK inhibitors for the treatment of proliferative diseases
US8383660B2 (en) * 2006-03-10 2013-02-26 Pfizer Inc. Dibenzyl amine compounds and derivatives

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102448965A (zh) * 2009-04-02 2012-05-09 阿勒根公司 前列腺素e受体拮抗剂
CN102448965B (zh) * 2009-04-02 2014-06-18 阿勒根公司 前列腺素e受体拮抗剂
CN110041269A (zh) * 2019-05-16 2019-07-23 海门瑞一医药科技有限公司 一种2-氯-5-羟基嘧啶的制备方法

Also Published As

Publication number Publication date
SV2009003407A (es) 2010-01-12
CA2686517A1 (en) 2008-11-20
DOP2009000256A (es) 2009-11-30
TW200904409A (en) 2009-02-01
MX2009011998A (es) 2009-11-19
CL2008001305A1 (es) 2008-07-18
JP2010526801A (ja) 2010-08-05
EP2155666A1 (en) 2010-02-24
EA200901381A1 (ru) 2010-06-30
WO2008139287A1 (en) 2008-11-20
MA31366B1 (fr) 2010-05-03
IL201874A0 (en) 2010-06-16
ECSP099727A (es) 2009-12-28
US20080280877A1 (en) 2008-11-13
CO6260066A2 (es) 2011-03-22
PE20090282A1 (es) 2009-03-27
AU2008249744A1 (en) 2008-11-20
AR066524A1 (es) 2009-08-26
TN2009000470A1 (fr) 2011-03-31
UY31070A1 (es) 2009-01-05
KR20100009582A (ko) 2010-01-27
BRPI0811444A2 (pt) 2014-10-29
PA8779601A1 (es) 2009-01-23
AP2009005047A0 (en) 2009-12-31
GT200900293A (es) 2010-05-17
CR11101A (es) 2009-12-04

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