TN2009000470A1 - Derives d'azetidine et leur utilisation comme antagonistes de prostaglandine e2 - Google Patents
Derives d'azetidine et leur utilisation comme antagonistes de prostaglandine e2Info
- Publication number
- TN2009000470A1 TN2009000470A1 TNP2009000470A TN2009000470A TN2009000470A1 TN 2009000470 A1 TN2009000470 A1 TN 2009000470A1 TN P2009000470 A TNP2009000470 A TN P2009000470A TN 2009000470 A TN2009000470 A TN 2009000470A TN 2009000470 A1 TN2009000470 A1 TN 2009000470A1
- Authority
- TN
- Tunisia
- Prior art keywords
- prostaglandin
- antagonists
- azetidine derivatives
- antagonist
- azetidine
- Prior art date
Links
- 239000005557 antagonist Substances 0.000 title abstract 3
- HONIICLYMWZJFZ-UHFFFAOYSA-N azetidine Chemical class C1CNC1 HONIICLYMWZJFZ-UHFFFAOYSA-N 0.000 title 1
- XEYBRNLFEZDVAW-ARSRFYASSA-N dinoprostone Chemical compound CCCCC[C@H](O)\C=C\[C@H]1[C@H](O)CC(=O)[C@@H]1C\C=C/CCCC(O)=O XEYBRNLFEZDVAW-ARSRFYASSA-N 0.000 title 1
- 229960002986 dinoprostone Drugs 0.000 title 1
- XEYBRNLFEZDVAW-UHFFFAOYSA-N prostaglandin E2 Natural products CCCCCC(O)C=CC1C(O)CC(=O)C1CC=CCCCC(O)=O XEYBRNLFEZDVAW-UHFFFAOYSA-N 0.000 title 1
- 201000010260 leiomyoma Diseases 0.000 abstract 2
- 201000009273 Endometriosis Diseases 0.000 abstract 1
- 206010046798 Uterine leiomyoma Diseases 0.000 abstract 1
- 150000001539 azetidines Chemical class 0.000 abstract 1
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 239000000543 intermediate Substances 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 238000003786 synthesis reaction Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
- C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
- C07D205/04—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/397—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having four-membered rings, e.g. azetidine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Reproductive Health (AREA)
- Endocrinology (AREA)
- Pulmonology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Gynecology & Obstetrics (AREA)
- Pregnancy & Childbirth (AREA)
- Physical Education & Sports Medicine (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US91708107P | 2007-05-10 | 2007-05-10 | |
| US1303007P | 2007-12-12 | 2007-12-12 | |
| PCT/IB2008/001070 WO2008139287A1 (en) | 2007-05-10 | 2008-04-28 | Azetidine derivatives and their use as prostaglandin e2 antagonists |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| TN2009000470A1 true TN2009000470A1 (fr) | 2011-03-31 |
Family
ID=39739736
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| TNP2009000470A TN2009000470A1 (fr) | 2007-05-10 | 2009-11-06 | Derives d'azetidine et leur utilisation comme antagonistes de prostaglandine e2 |
Country Status (27)
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20100256109A1 (en) * | 2007-11-15 | 2010-10-07 | Sarah Elizabeth Skerratt | Azetidines As EP2 Antagonists |
| PE20110663A1 (es) * | 2008-11-10 | 2011-09-23 | Pfizer Ltd | Pirrolidinas |
| WO2010114997A1 (en) * | 2009-04-02 | 2010-10-07 | Allergan, Inc. | Prostaglandin e receptor antagonists |
| DE102009049662A1 (de) | 2009-10-13 | 2011-04-14 | Bayer Schering Pharma Aktiengesellschaft | 2,5-Disubstituierte 2H-Indazole als EP2-Rezeptor-Antagonisten |
| WO2013010679A1 (en) | 2011-07-15 | 2013-01-24 | Novartis Ag | Salts of aza-bicyclic di-aryl ethers and methods to make them or their precursors |
| TW201326154A (zh) | 2011-11-28 | 2013-07-01 | 拜耳知識產權公司 | 作為ｅｐ２受體拮抗劑之新穎２ｈ－吲唑 |
| EP3237401B1 (en) | 2014-12-22 | 2019-03-06 | Pfizer Inc | Antagonists of prostaglandin ep3 receptor |
| CN110041269A (zh) * | 2019-05-16 | 2019-07-23 | 海门瑞一医药科技有限公司 | 一种2-氯-5-羟基嘧啶的制备方法 |
| US12703680B2 (en) | 2019-11-21 | 2026-08-11 | University Of Utah Research Foundation | TRPV4 receptor ligands |
| JP2024524986A (ja) | 2021-06-24 | 2024-07-09 | レザボア ニューロサイエンス，インコーポレイテッド | Ｅｐ２アンタゴニスト化合物 |
| EP4359399A4 (en) * | 2021-06-24 | 2025-04-23 | Reservoir Neuroscience, Inc. | EP2 antagonist compounds |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB8300860D0 (en) * | 1983-01-13 | 1983-02-16 | Shell Int Research | Azetidine compounds |
| GB8415614D0 (en) * | 1984-06-19 | 1984-07-25 | Shell Int Research | Azetidine derivatives |
| GB8509746D0 (en) * | 1985-04-16 | 1985-05-22 | Shell Int Research | Preparing azetidine derivatives |
| AR037364A1 (es) | 2001-11-16 | 2004-11-03 | Schering Corp | Azetidinil diaminas utiles como ligandos del receptor de nociceptina orl-1 |
| NZ567140A (en) * | 2005-10-07 | 2011-09-30 | Exelixis Inc | Azetidines as MEK inhibitors for the treatment of proliferative diseases |
| US8383660B2 (en) * | 2006-03-10 | 2013-02-26 | Pfizer Inc. | Dibenzyl amine compounds and derivatives |
-
2008
- 2008-04-28 AU AU2008249744A patent/AU2008249744A1/en not_active Abandoned
- 2008-04-28 KR KR1020097025684A patent/KR20100009582A/ko not_active Ceased
- 2008-04-28 BR BRPI0811444-7A2A patent/BRPI0811444A2/pt not_active IP Right Cessation
- 2008-04-28 JP JP2010507013A patent/JP2010526801A/ja not_active Withdrawn
- 2008-04-28 AP AP2009005047A patent/AP2009005047A0/en unknown
- 2008-04-28 WO PCT/IB2008/001070 patent/WO2008139287A1/en not_active Ceased
- 2008-04-28 MX MX2009011998A patent/MX2009011998A/es not_active Application Discontinuation
- 2008-04-28 EP EP08737574A patent/EP2155666A1/en not_active Withdrawn
- 2008-04-28 CA CA002686517A patent/CA2686517A1/en not_active Abandoned
- 2008-04-28 CN CN200880019555A patent/CN101679235A/zh active Pending
- 2008-04-28 EA EA200901381A patent/EA200901381A1/ru unknown
- 2008-05-05 US US12/115,070 patent/US20080280877A1/en not_active Abandoned
- 2008-05-06 CL CL200801305A patent/CL2008001305A1/es unknown
- 2008-05-08 UY UY31070A patent/UY31070A1/es not_active Application Discontinuation
- 2008-05-08 PE PE2008000813A patent/PE20090282A1/es not_active Application Discontinuation
- 2008-05-08 PA PA20088779601A patent/PA8779601A1/es unknown
- 2008-05-09 AR ARP080101988A patent/AR066524A1/es unknown
- 2008-05-09 TW TW097117225A patent/TW200904409A/zh unknown
-
2009
- 2009-11-01 IL IL201874A patent/IL201874A0/en unknown
- 2009-11-05 DO DO2009000256A patent/DOP2009000256A/es unknown
- 2009-11-06 TN TNP2009000470A patent/TN2009000470A1/fr unknown
- 2009-11-06 SV SV2009003407A patent/SV2009003407A/es not_active Application Discontinuation
- 2009-11-09 CR CR11101A patent/CR11101A/es not_active Application Discontinuation
- 2009-11-09 CO CO09126880A patent/CO6260066A2/es not_active Application Discontinuation
- 2009-11-10 EC EC2009009727A patent/ECSP099727A/es unknown
- 2009-11-10 MA MA32331A patent/MA31366B1/fr unknown
- 2009-11-10 GT GT200900293A patent/GT200900293A/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| SV2009003407A (es) | 2010-01-12 |
| CA2686517A1 (en) | 2008-11-20 |
| DOP2009000256A (es) | 2009-11-30 |
| TW200904409A (en) | 2009-02-01 |
| MX2009011998A (es) | 2009-11-19 |
| CL2008001305A1 (es) | 2008-07-18 |
| JP2010526801A (ja) | 2010-08-05 |
| EP2155666A1 (en) | 2010-02-24 |
| EA200901381A1 (ru) | 2010-06-30 |
| WO2008139287A1 (en) | 2008-11-20 |
| CN101679235A (zh) | 2010-03-24 |
| MA31366B1 (fr) | 2010-05-03 |
| IL201874A0 (en) | 2010-06-16 |
| ECSP099727A (es) | 2009-12-28 |
| US20080280877A1 (en) | 2008-11-13 |
| CO6260066A2 (es) | 2011-03-22 |
| PE20090282A1 (es) | 2009-03-27 |
| AU2008249744A1 (en) | 2008-11-20 |
| AR066524A1 (es) | 2009-08-26 |
| UY31070A1 (es) | 2009-01-05 |
| KR20100009582A (ko) | 2010-01-27 |
| BRPI0811444A2 (pt) | 2014-10-29 |
| PA8779601A1 (es) | 2009-01-23 |
| AP2009005047A0 (en) | 2009-12-31 |
| GT200900293A (es) | 2010-05-17 |
| CR11101A (es) | 2009-12-04 |
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