CN101653579A - Traditional Chinese medicine preparation for treating intractable insomnia - Google Patents
Traditional Chinese medicine preparation for treating intractable insomnia Download PDFInfo
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- CN101653579A CN101653579A CN200910084303A CN200910084303A CN101653579A CN 101653579 A CN101653579 A CN 101653579A CN 200910084303 A CN200910084303 A CN 200910084303A CN 200910084303 A CN200910084303 A CN 200910084303A CN 101653579 A CN101653579 A CN 101653579A
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Abstract
The invention discloses a traditional Chinese medicine preparation for treating intractable insomnia, which is made of traditional Chinese medicine raw materials based on parts by weight: 18-22 partsof uncaria rhynchophylla, 18-22 parts of the root of red-rooted salvia, 18-22 parts of nacre, 13-17 parts of selfheal, 13-17 parts of spina date seed, 10-14 parts of flower of silktree albizzia, 8-12parts of backed licorice, 10-14 parts of radix paeoniae alba, 18-22 parts of raw raidx astragali and 3-7 parts of fructus amomi. The traditional Chinese medicine preparation has the function of clearing and nourishing liver as well as calming the heart and tranquilizing the mind, is better in the effect of treating the intractable insomnia, and achieves the aim of treating both the incidental andfundamental aspects.
Description
Technical field
The present invention relates to a kind of Chinese medicine preparation that is used for the treatment of intractable insomnia.
Background technology
Insomnia is a kind of common disease, along with the change of life, social activity environment, becomes the able-bodied key factor of influence all the more, and its treatment also is subjected to people's attention and attention day by day.According to statistics, the insomniac of the U.S. expects mid-21st Century and will reach 100,000,000 people up to 4,000 ten thousand～6,000 ten thousand people.Domestic investigation statistics result shows that the prevalence of insomnia disease is up to 42%.Do not cause learning because of having enough sleep, decline, sick leave, medical expense and the sudden hurt accident etc. of work efficiency and production, its economic loss is difficult to estimate.
The most course of disease of intractable insomnia patient is longer, is in nervous state for a long time, and mental burden is heavy, so feel depressed, influences the catharsis function of liver, causes depression of liver-QI; Otherwise, the catharsis hypofunction of liver, depression of liver-QI, mood is easier to depression.
At present, adopt the diazepam Cure for insomnia usually, but curative effect is little, and side effect being big, therefore seeking the medicine of the treatment by Chinese herbs insomnia with Chinese quintessence of Chinese culture, is the common hope of pursuing of doctor and patient.
Summary of the invention
At above-mentioned situation, the purpose of this invention is to provide a kind of Chinese medicine preparation for the treatment of intractable insomnia, intractable insomnia can be effectively treated, and side effect minimum can be dropped to.
To achieve these goals, the present invention adopts Ramulus Uncariae Cum Uncis, Radix Salviae Miltiorrhizae, Concha Margaritifera, Spica Prunellae 13-17 weight portion, Semen Ziziphi Spinosae, Flos Albiziae, Radix Glycyrrhizae Preparata, the Radix Paeoniae Alba, Radix Astragali, the Fructus Amomi reasonable compatibility, be processed into the Chinese medicine preparation of Cure for insomnia through science, the weight portion proportioning is respectively: Ramulus Uncariae Cum Uncis 18-22 weight portion, Radix Salviae Miltiorrhizae 18-22 weight portion, Concha Margaritifera 18-22 weight portion, Spica Prunellae 13-17 weight portion, Semen Ziziphi Spinosae 13-17 weight portion, Flos Albiziae 10-14 weight portion, Radix Glycyrrhizae Preparata 8-12 weight portion, Radix Paeoniae Alba 10-14 weight portion, Radix Astragali 18-22 weight portion, Fructus Amomi 3-7 weight portion.
Described Chinese medicine preparation is a said dosage form on any materia medica.
Described dosage form is a capsule, tablet, granule, oral liquid, pill, powder, sublimed preparation, any pharmaceutical dosage form in the unguentum.
Beneficial effect of the present invention is:
The present invention can take into account by liver heat removing nourishing the liver mind tranquilizing and the heart calming, can obtain better curative effect, treating both the principal and the secondary aspects of a disease at the same time to intractable insomnia.
The specific embodiment
Below in conjunction with embodiment and practical situation the present invention is elaborated.
The prescription requirement according to the present invention, in weight portion proportioning Ramulus Uncariae Cum Uncis 18 weight portions, Radix Salviae Miltiorrhizae 18 weight portions, Concha Margaritifera 18 weight portions, Spica Prunellae 13 weight portions, Semen Ziziphi Spinosae 13 weight portions, Flos Albiziae 10 weight portions, Radix Glycyrrhizae Preparata 8 weight portions, the Radix Paeoniae Alba 10 weight portions, Radix Astragali 18 weight portions, Fructus Amomi 3 weight portions are mixed and made into Chinese medicine preparation.
Ramulus Uncariae Cum Uncis, Spica Prunellae removing heat from the liver are principal agent in above-mentioned prescription, Concha Margaritifera suppressing the hyperactive liver sun, and Flos Albiziae is calmed the nerves and separates clothes, and Semen Ziziphi Spinosae, Radix Glycyrrhizae, the Radix Paeoniae Alba, Radix Salviae Miltiorrhizae are taken a tonic or nourishing food to build up one's health liver blood, tranquilizing by nourishing the heart, Radix Astragali QI invigorating and blood regulating, the Fructus Amomi appetizing of being amusing makes strong fortune of the source of vital function of QI and blood.Above-mentioned science compatibility can reach the effect of liver heat removing nourishing the liver mind tranquilizing and the heart calming jointly, thereby makes insomnia be able to effective treatment.
Below the effect of mouse experiment and clinical practice treatment depression has all been obtained fully proving.
The pharmacodynamics pharmacological toxicology is learned situation
According to bureau of drug administration of People's Republic of China (PRC) new drug research guideline, show that after deliberation changing Chinese medicine preparation has inhibitory action to nervus centralis, the appropriate sleeping number of subliminal hypnosis dosage of receiving of experiment mice penta crust is obviously increased, the sleep time-lag action is arranged.Show through animal acute toxicity test, be equivalent to 300 times of people's clinical application amount with this Chinese medicine preparation suspension to mouse stomach, mice does not have movable unusual, does not more see death, so as safe as a house during this Chinese medicine preparation oral administration.This Chinese medicine preparation long term toxicity test studies show that this Chinese medicine preparation does not have influence to the normal growth growth of rat, and the every index of hemogram checking is all in normal range, and this Chinese medicine preparation has no adverse effects to the hemopoietic function of rat, does not damage hepatic and renal function.The all no abnormal pathologic of main organs pathological examination changes, and illustrates that this Chinese medicine preparation is very safe.
In order further to estimate the clinical efficacy of this Chinese medicine preparation, 101 routine insomnia patientses are observed, and to establish diazepam be matched group that the observation of system has been carried out in its curative effect, safety and side effect, and situation is as follows:
1, alternative
1.1 all case is divided into two groups at random.Treatment is organized in 58 examples, male 23 examples, women 35 examples; Year at age (51.78 ± 2.55); The course of disease (2.85 ± 0.58) year.In matched group 43 examples, male 16 examples, women 27 examples; Year at age (52.39 ± 2.65); The course of disease (2.76 ± 0.68) year.Two groups of clinical datas are learned processing difference is not by statistics had significance (P＞0.05).
There is the patient all to meet " new Chinese medicine Cure for insomnia clinical research guideline " diagnostic criteria 1.2 go into the group standard.1) classical symptom of insomnia is arranged: difficulty falling asleep, awakening often, sleep and unstable or wake up after can not sleep again, wake up morning too early, can not fall asleep night, the lethargic and drowsy state of swooning daytime, 5h does not have enough sleep; 2) there is history of repeated attack to reach more than 3 months; 3) any sedative hypnotic drug is not taken in preceding 1 week by people institute.4) get rid of case standard (comprising inadaptation or rejecting standard): every systemic disease such as pain, heating, cough, operation and external environmental interference factor causer; Age is the person below 16 one full year of life or more than 70 years old, the trimester of pregnancy women breast-feeding their children; Be associated with serious primary disease person such as cardiovascular, lung, liver, kidney and hemopoietic system, the psychotic; All standards of including in that do not meet, not medication in accordance with regulations can't be judged that curative effect or data are not congruent to affect the treatment and safety judgement person.
2, the administrated method and the course of treatment
2.1 treatment
All cases of GP TH are all used oryzanol tablets treatment, every day 60mg, divide 3 times oral.
The Chinese medicine preparation group adds this Chinese medicine preparation, every day 2 times, each 1 time sooner or later, each 1 bag, every bag of about 20G;
Matched group: add diazepam 5mg.All taking medicine in 22.00 o'clock every night.Two groups were for 2 all 1 courses of treatment, observed for 1 course of treatment altogether.
Before organizing, observational technique patient people carries out traditional Chinese medical science four diagnostic methods gather material and routine blood test, blood biochemistry, Electrocardiographic inspection.The length of one's sleep and sleep awakening degree before and after the observation treatment, the mental status after the awakening.
3, result
3.1 criterion of therapeutical effect is according to the definite curative effect determinate standard of Ministry of Public Health " the clinical research index principle of new Chinese medicine Cure for insomnia ".Clinical recovery: recover normal the length of one's sleep, more than the nighttime sleep time 6h, sleep is dull, and the back of waking up is hale and hearty; Produce effects: sleep is clearly better, and increases the length of one's sleep more than the 3h, and Depth of sleep increases; Effectively: sx, asking during sleep increases not enough 3h; Invalid: the insomnia of treatment back does not have obvious the improvement.
3.2 two groups of curative effects of therapeutic outcome relatively, sees Table 1.
Table 1 liang group 1 clinical efficacy relatively
| ??n | Clinical recovery | Produce effects | Effectively | Invalid | Total effective rate | |
| The Chinese medicine preparation group | ??58 | ??19 | ??16 | ??22 | ??1 | ??98.28 |
| Matched group | ??43 | ??4 | ??8 | ??12 | ??19 | ??55.81 |
Annotate: two groups of total effective rates are checked through X2, and there is significant difference P＜0.05.
4, conclusion
The most course of disease of intractable insomnia patient is longer, is in nervous state for a long time, and mental burden is heavy, so feel depressed, influences the catharsis function of liver, causes depression of liver-QI; Otherwise, the catharsis hypofunction of liver, depression of liver-QI, mood is easier to depression.This Chinese medicine preparation has liver clearing and depression relieving, QI invigorating and blood regulating, the effect of tranquilizing by nourishing the heart.This Chinese medicine preparation cures mainly: deficiency of liver-blood, and blood failing to tonify the heart, stagnation of liver-QI is heat-transformation with the passing of time.Disease opinion is insomnia or little sleep disturbed by dreams, and is forgetful, and cardiopalmus is dizzy unclear, spiritlessness and weakness, and indigestion and loss of appetite loss of appetite, the few tongue of red tongue is a little less than the stringy and thready pulse.Ramulus Uncariae Cum Uncis, Spica Prunellae removing heat from the liver are principal agent in the Chinese medicine preparation, Concha Margaritifera suppressing the hyperactive liver sun, and Flos Albiziae is calmed the nerves and separates clothes, and Semen Ziziphi Spinosae, Radix Glycyrrhizae, the Radix Paeoniae Alba, Radix Salviae Miltiorrhizae are taken a tonic or nourishing food to build up one's health liver blood, tranquilizing by nourishing the heart, Radix Astragali QI invigorating and blood regulating, the Fructus Amomi appetizing of being amusing makes strong fortune of the source of vital function of QI and blood.So the present invention can take into account by liver heat removing nourishing the liver mind tranquilizing and the heart calming, can obtain better curative effect, treating both the principal and the secondary aspects of a disease at the same time to intractable insomnia.
Claims (3)
1, a kind of Chinese medicine preparation for the treatment of intractable insomnia is characterized in that, it is by following column weight
An amount part Chinese medicinal raw materials is made:
Ramulus Uncariae Cum Uncis 18-22 weight portion
Radix Salviae Miltiorrhizae 18-22 weight portion
Concha Margaritifera 18-22 weight portion
Spica Prunellae 13-17 weight portion
Semen Ziziphi Spinosae 13-17 weight portion
Flos Albiziae 10-14 weight portion
Radix Glycyrrhizae Preparata 8-12 weight portion
Radix Paeoniae Alba 10-14 weight portion
Radix Astragali 18-22 weight portion
Fructus Amomi 3-7 weight portion.
2, Chinese medicine preparation according to claim 1 is characterized in that: described Chinese medicine preparation is a said dosage form on any materia medica.
3, Chinese medicine preparation according to claim 2 is characterized in that: described dosage form is a capsule, tablet, granule, oral liquid, pill, powder, sublimed preparation, any pharmaceutical dosage form in the unguentum.
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| Application Number | Priority Date | Filing Date | Title |
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| CN200910084303A CN101653579A (en) | 2009-05-20 | 2009-05-20 | Traditional Chinese medicine preparation for treating intractable insomnia |
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| Application Number | Priority Date | Filing Date | Title |
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| CN200910084303A CN101653579A (en) | 2009-05-20 | 2009-05-20 | Traditional Chinese medicine preparation for treating intractable insomnia |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102935185A (en) * | 2012-11-25 | 2013-02-20 | 王广生 | Pills for treating neurasthenia and preparation method |
| CN105902933A (en) * | 2016-05-24 | 2016-08-31 | 内蒙古中安类风湿骨关节病专科医院有限责任公司 | Chinese medicinal preparation for treating insomnia |
-
2009
- 2009-05-20 CN CN200910084303A patent/CN101653579A/en active Pending
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102935185A (en) * | 2012-11-25 | 2013-02-20 | 王广生 | Pills for treating neurasthenia and preparation method |
| CN102935185B (en) * | 2012-11-25 | 2014-04-16 | 王广生 | Pills for treating neurasthenia and preparation method |
| CN105902933A (en) * | 2016-05-24 | 2016-08-31 | 内蒙古中安类风湿骨关节病专科医院有限责任公司 | Chinese medicinal preparation for treating insomnia |
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Application publication date: 20100224 |