CN101653573A - Traditional Chinese medicine preparation for treating insomnia - Google Patents
Traditional Chinese medicine preparation for treating insomnia Download PDFInfo
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- CN101653573A CN101653573A CN200910084309A CN200910084309A CN101653573A CN 101653573 A CN101653573 A CN 101653573A CN 200910084309 A CN200910084309 A CN 200910084309A CN 200910084309 A CN200910084309 A CN 200910084309A CN 101653573 A CN101653573 A CN 101653573A
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Abstract
The invention discloses a traditional Chinese medicine preparation for treating insomnia, which is made of traditional Chinese medicine raw materials based on parts by weight: 8-12 parts of grass leafsweelflag rhizome, 10-14 parts of lotus plumule, 43-47 parts of lily, 18-22 parts of spina date seed, 8-12 parts of citrus chachiensis hortorum, 10-14 parts of poria cocos, 28-32 parts of light wheat, 18-22 parts of raw fossilizid, 18-22 parts of raw oyster shell, 18-22 parts of dried longan, 3-7 parts of backed licorice and 1-3 parts of cinnabar. The traditional Chinese medicine preparation hasthe functions of sedation and hypnosis, and reliable effect in treating insomnia with less untoward effect, thus being suitable for clinical use.
Description
Technical field
The present invention relates to a kind of Chinese medicine preparation that is used for the treatment of insomnia.
Background technology
Insomnia is a kind of common disease, along with the change of life, social activity environment, becomes the able-bodied key factor of influence all the more, and its treatment also is subjected to people's attention and attention day by day.According to statistics, the insomniac of the U.S. expects mid-21st Century and will reach 100,000,000 people up to 4,000 ten thousand～6,000 ten thousand people.Domestic investigation statistics result shows that the prevalence of insomnia disease is up to 42%.Do not cause learning because of having enough sleep, decline, sick leave, medical expense and the sudden hurt accident etc. of work efficiency and production, its economic loss is difficult to estimate.
Adopt the western medicine insomnia at present again, but side effect being big, therefore seeking the medicine of the treatment by Chinese herbs insomnia with Chinese quintessence of Chinese culture, is the common hope of pursuing of doctor and patient.
Summary of the invention
At above-mentioned situation, the purpose of this invention is to provide a kind of Chinese medicine preparation of Cure for insomnia, energy is Cure for insomnia effectively, and side effect can be dropped to minimum.
To achieve these goals, the present invention adopts Rhizoma Acori Graminei, Plumula Nelumbinis, Bulbus Lilii, Semen Ziziphi Spinosae, Pericarpium citri reticuatae chachiensis, Poria, Fructus Tritici Levis, Os Draconis, Concha Ostreae, Arillus Longan, Radix Glycyrrhizae Preparata, the Cinnabaris reasonable compatibility is processed into the Chinese medicine preparation of Cure for insomnia through science, and the weight portion proportioning is respectively: Rhizoma Acori Graminei 8-12 weight portion, Plumula Nelumbinis 10-14 weight portion, Bulbus Lilii 43-47 weight portion, Semen Ziziphi Spinosae 18-22 weight portion, Pericarpium citri reticuatae chachiensis 8-12 weight portion, Poria 10-14 weight portion, Fructus Tritici Levis 28-32 weight portion, Os Draconis 18-22 weight portion, Concha Ostreae 18-22 weight portion, Arillus Longan 8-12 weight portion, Radix Glycyrrhizae Preparata 3-7 weight portion, Cinnabaris 1-3 weight portion.
Described Chinese medicine preparation is a said dosage form on any materia medica.
Described dosage form is a capsule, tablet, granule, oral liquid, pill, powder, sublimed preparation, any pharmaceutical dosage form in the unguentum.
Beneficial effect of the present invention is:
The present invention has sedative-hypnotic effect, be used for the treatment of the insomnia curative effect certainly, and untoward reaction is few, is fit to clinical use.
The specific embodiment
Below in conjunction with embodiment and practical situation the present invention is elaborated.
The prescription requirement according to the present invention is in weight portion proportioning Rhizoma Acori Graminei 8 weight portions, Plumula Nelumbinis 10 weight portions, Bulbus Lilii 43 weight portions, Semen Ziziphi Spinosae 18 weight portions, Pericarpium citri reticuatae chachiensis 8 weight portions, Poria 10 weight portions, Fructus Tritici Levis 28 weight portions, Os Draconis 18 weight portions, Concha Ostreae 18 weight portions, Arillus Longan 8 weight portions, Radix Glycyrrhizae Preparata 3 weight portions, Cinnabaris 1 weight portion is mixed and made into Chinese medicine preparation.
In above-mentioned prescription, use Bulbus Lilii, the sub-heart, Semen Ziziphi Spinosae clearing away heart-fire for tranquillization, Rhizoma Acori Graminei, Pericarpium Citri Reticulatae, Poria, waking up the patient from unconsciousness by dissipating phlegm, Os Draconis, Concha Ostreae, Cinnabaris tranquilizing to ease mentle strain sedate, Fructus Tritici Levis, Arillus Longan, Radix Glycyrrhizae Preparata nourish heart and hold back the refreshing fidgets due to deficiency of removing, can be by influence the interior 5-hydroxy tryptamine of brain, the content of norepinephrine, dopamine and increase sound sleep.Above-mentioned science compatibility can reach the effect of tranquilizing soporific jointly, thereby makes insomnia be able to effective treatment.
Below the effect of mouse experiment and clinical practice treatment depression has all been obtained fully proving.
The pharmacodynamics pharmacological toxicology is learned situation
According to bureau of drug administration of People's Republic of China (PRC) new drug research guideline, show that after deliberation changing Chinese medicine preparation has inhibitory action to nervus centralis, the appropriate sleeping number of subliminal hypnosis dosage of receiving of experiment mice penta crust is obviously increased, the sleep time-lag action is arranged.Show through animal acute toxicity test, be equivalent to 300 times of people's clinical application amount with this Chinese medicine preparation suspension to mouse stomach, mice does not have movable unusual, does not more see death, so as safe as a house during this Chinese medicine preparation oral administration.This Chinese medicine preparation long term toxicity test studies show that this Chinese medicine preparation does not have influence to the normal growth growth of rat, and the every index of hemogram checking is all in normal range, and this Chinese medicine preparation has no adverse effects to the hemopoietic function of rat, does not damage hepatic and renal function.The all no abnormal pathologic of main organs pathological examination changes, and illustrates that this Chinese medicine preparation is very safe.
In order further to estimate the clinical efficacy of this Chinese medicine preparation, 43 routine insomnia patientses are observed, and to establish the paroxetine sheet be matched group that the observation of system has been carried out in its curative effect, safety and side effect, and situation is as follows:
1, alternative
Be divided into Chinese medicine preparation group 29 examples at random, male 11 examples, women 18 examples, average 44 ± 13.56 years old, go into to organize base line insomnia severity (sleep state questionnaire scale) 23.89 ± 4.52 minutes at age 25-65 year.Matched group 24 examples, male 9 examples, women 15 examples, average 44.08 ± 15.10 years old, go into to organize base line insomnia severity (sleep state questionnaire scale) 23.94 ± 4.63 minutes at age 24-66 year.2 groups of patient's data are learned processing difference is not by statistics had significance (P 〉=0.05).
2, the administrated method and the course of treatment
2.1 treatment
Oral this Chinese medicine preparation of this Chinese medicine preparation group, every day 2 times, each 1 time sooner or later, each 1 bag, every bag of about 25G; It is oral that matched group gives paroxetine sheet (Sino-America Tianjin Shike Pharmaceutical Co., Ltd.'s production), each 20mg, every day 1 time.2 groups of patients all are aided with the psychotherapy, examine the psychotherapy about about 45min at every turn, and it is too drastic to advise it to control the emotion, and broadens one's mind, and the emotion that keeps pleasant is annotated dietetic care, appropriate exercise.Statistics curative effect after 4 weeks.
3, result
3.1 totally 7 of criterion of therapeutical effect SQ, relate to conscious sleep whether abundance, rest degree, the length of one's sleep, difficulty falling asleep, easily wake up, early awakening and take sleeping pill situation etc. (sleeping pill is not taken in this research, so this omits), observe preceding 6 projects, and calculate the degree of total score value to quantize insomnia and to improve.The total score value of sleep state questionnaire subtracts branch rate=(total points before the treatment+treatment back the total points)/preceding total points of treatment * 100%.The sleep score value subtracts branch rate 〉=75% and is recovery from illness, and 〉=50% is produce effects, and 〉=30% is that effectively＜30% is invalid.
3.2 clinical efficacy Chinese medicine preparation group: 7 examples of fully recovering, produce effects 10 examples, effective 10 examples, invalid 2 examples, total effective rate 93.10%.Matched group: 5 examples of fully recovering, produce effects 8 examples, effective 9 examples, invalid 2 examples, total effective rate 91.67%.The difference that compares between 2 groups does not have significance (P 〉=0.05), illustrates that 2 groups of general curative effects are suitable.
3.3 treat the 2 groups of SAS in back, SDS score values relatively: all descend after table 1,2 groups of SAS of table 2 expression, the treatment of SDS score value than before treating, its mark self relatively, difference all has significance (P＜0.05), relatively, treatment back SAS, the SDS score value subtracts branch rate comparing difference does not have significance (P＞0.05) between 2 groups.Explanation aspect antidepressant and anxiety effect, 2 groups whole therapeutic equivalence.
The SAS scoring changes relatively before and after 2 groups of treatments of table 1
| Group | The example number | Before the treatment (branch) | Treatment back (branch) | Subtract branch rate (%) |
| The Chinese medicine preparation group | ??29 | ??61.87±7.75 | ??42.24±8.23 | ??30.05±12.89 |
| Matched group | ??24 | ??59.59±6.43 | ??44.57±9.66 | ??29.56±13.95 |
The SDS scoring changes relatively before and after 2 groups of treatments of table 2
| Group | The example number | Before the treatment (branch) | Treatment back (branch) | Subtract branch rate (%) |
| The Chinese medicine preparation group | ??29 | ??66.73±9.65 | ??47.74±10.04 | ??28.03±13.16 |
| Matched group | ??24 | ??63.70±7.75 | ??44.57±11.55 | ??28.11±13.35 |
3.4 slight weak 1 example (3.45%) appears in untoward reaction Chinese medicine preparation group, the matched group side reaction is more relatively, be respectively dizziness headache 2 examples (8.33%), constipation 3 examples (12.50%), xerostomia 2 examples (8.33%), cardiopalmus 1 example (4.17%), sleepy weak 1 example (4.17%), illustrate the patient take this Chinese medicine preparation after untoward reaction less.
4, conclusion
Feelings will factor has become the main cause that causes insomnia.The effect that the present invention has the clearing away heart-fire for tranquillization sedate, the YANG hyperactivity suppressing of reducing phlegm is had one's ideas straightened out.Use Bulbus Lilii, the sub-heart, Semen Ziziphi Spinosae clearing away heart-fire for tranquillization in this Chinese medicine preparation, Rhizoma Acori Graminei, Pericarpium Citri Reticulatae, Poria, waking up the patient from unconsciousness by dissipating phlegm, Os Draconis, Concha Ostreae, Cinnabaris tranquilizing to ease mentle strain sedate, Fructus Tritici Levis, Arillus Longan, Radix Glycyrrhizae Preparata nourish heart and hold back the refreshing fidgets due to deficiency of removing, can be by influence the interior 5-hydroxy tryptamine of brain, the content of norepinephrine, dopamine and increase sound sleep.Paroxetine is an antidepressant drug of new generation, and the energy selectivity suppresses the reuptake of 5-hydroxy tryptamine, improves the concentration of 5-hydroxy tryptamine in the nerve synapse gap, thereby produces antidepressant effect; It can also faintly suppress the reuptake of norepinephrine and dopamine, is used for the treatment of depression and anxiety symptom that occurs together and sleep disorder.This medicine once was widely used as the positive control medicine in the clinical research of Drug therapy insomnia, to disclose antidepressant, anxiety and the sedative-hypnotic effect of object of study.
By above experiment, prove that this Chinese medicine preparation has sedative-hypnotic effect, the Cure for insomnia curative effect is affirmed, and untoward reaction is few, is fit to clinical use.
Claims (3)
1, a kind of Chinese medicine preparation for the treatment of nervous depression is characterized in that, it is by following
Chinese medicinal raw materials in portion by weight is made:
Rhizoma Acori Graminei 8-12 weight portion
Plumula Nelumbinis 10-14 weight portion
Bulbus Lilii 43-47 weight portion
Semen Ziziphi Spinosae 18-22 weight portion
Pericarpium citri reticuatae chachiensis 8-12 weight portion
Poria 10-14 weight portion
Fructus Tritici Levis 28-32 weight portion
Os Draconis 18-22 weight portion
Concha Ostreae 18-22 weight portion
Arillus Longan 8-12 weight portion
Radix Glycyrrhizae Preparata 3-7 weight portion
Cinnabaris 1-3 weight portion.
2, Chinese medicine preparation according to claim 1 is characterized in that: described Chinese medicine preparation is a said dosage form on any materia medica.
3, Chinese medicine preparation according to claim 2 is characterized in that: described dosage form is a capsule, tablet, granule, oral liquid, pill, powder, sublimed preparation, any pharmaceutical dosage form in the unguentum.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN200910084309A CN101653573A (en) | 2009-05-20 | 2009-05-20 | Traditional Chinese medicine preparation for treating insomnia |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN200910084309A CN101653573A (en) | 2009-05-20 | 2009-05-20 | Traditional Chinese medicine preparation for treating insomnia |
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| CN101653573A true CN101653573A (en) | 2010-02-24 |
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| CN200910084309A Pending CN101653573A (en) | 2009-05-20 | 2009-05-20 | Traditional Chinese medicine preparation for treating insomnia |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103404845A (en) * | 2013-05-27 | 2013-11-27 | 胡安然 | Special diet for insomnia patients |
| CN103550629A (en) * | 2013-11-06 | 2014-02-05 | 攀枝花学院 | Lucid ganoderma nerve-soothing composition, medicinal tea, making method and application thereof |
| CN103961574A (en) * | 2014-05-05 | 2014-08-06 | 伍广俊 | Medicament for treating insomnia |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101249227A (en) * | 2008-04-10 | 2008-08-27 | 北京万寿通医药科技有限公司 | Ginseng and astragalus psyche-nourishing capsules |
-
2009
- 2009-05-20 CN CN200910084309A patent/CN101653573A/en active Pending
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101249227A (en) * | 2008-04-10 | 2008-08-27 | 北京万寿通医药科技有限公司 | Ginseng and astragalus psyche-nourishing capsules |
Non-Patent Citations (3)
| Title |
|---|
| 无: "心脏神经官能症方", 《家庭医药》 * |
| 石春明等: "中医治疗失眠的研究近况", 《陕西中医学院学报》 * |
| 苏荣立等: "加味桂甘龙牡汤治疗56例老年失眠证体会", 《中医药信息》 * |
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103404845A (en) * | 2013-05-27 | 2013-11-27 | 胡安然 | Special diet for insomnia patients |
| CN103404845B (en) * | 2013-05-27 | 2015-03-11 | 胡安然 | Special diet for insomnia patients |
| CN103550629A (en) * | 2013-11-06 | 2014-02-05 | 攀枝花学院 | Lucid ganoderma nerve-soothing composition, medicinal tea, making method and application thereof |
| CN103550629B (en) * | 2013-11-06 | 2015-09-30 | 攀枝花学院 | Glossy ganoderma for tranquilization compositions, medicinal tea and preparation method thereof and purposes |
| CN103961574A (en) * | 2014-05-05 | 2014-08-06 | 伍广俊 | Medicament for treating insomnia |
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Application publication date: 20100224 |