CN104623382B - A kind of Chinese medicine for treating type of phlegm-heat attacking internally insomnia - Google Patents

Abstract

The invention relates to a traditional Chinese medicine for treating insomnia of the phlegm-heat internal disturbance type, which can effectively solve the medication problem of the phlegm-heat internal disturbance type insomnia. Summer 30-60g, Prunella vulgaris 20-30g, Tianzhuhuang 20-30g, Suanzaoren 30-40g, Fushen 10-15g, Zhuru 15-20g and Shenglongchi 20-30g, mix the above raw materials together, Put it into the medicine pot, add water to soak, soak for 30‑60min, decoct with strong fire until boiling, then switch to slow fire for 30min, filter to get the filtrate, add water to the filter residue, decoct with strong fire until boiling, then switch to slow fire for decoction Filtrate for 30 minutes to obtain the filtrate, and combine the filtrate twice to complete. The present invention has rich raw materials, scientific components, reasonable compatibility, and mutual support. It has the functions of clearing away heat, reducing phlegm, and calming the nerves, and is effective for treating insomnia of phlegm-heat internal disturbance type. , good efficacy, safe medication, no side effects, is an innovation in the treatment of phlegm-heat internal disturbance type insomnia drugs.

Description

A traditional Chinese medicine for treating insomnia of phlegm-heat internal disturbance type

technical field

The invention relates to medicine, in particular to a traditional Chinese medicine for treating insomnia of phlegm-heat internal disturbance type.

Background technique

Insomnia is the most common clinical sleep disorder type. Long-term insomnia will have a serious negative impact on normal life and work, and even lead to vicious accidents. Insomnia belongs to the category of "insomnia" and "insomnia" in traditional Chinese medicine. It mainly occurs due to evil disturbance of the mind or lack of nourishment of the mind, resulting in yang not communicating with yin or mind not keeping the house. Throughout the history of physicians, combined with clinical experience, it is believed that phlegm-heat internal disturbance type insomnia is a relatively common type of insomnia in clinical practice. "The Encyclopedia of Ancient and Modern Medicine" states: "There are many people who are disturbed by phlegm fire, restless, thinking about injuries, burning phlegm and causing insomnia." . Treatment is mainly based on clearing heart-fire and reducing fire, resolving phlegm and calming the nerves. Chinese medicine is extensive and profound, therefore, it is imperative to provide a kind of Chinese medicine for the treatment of phlegm-heat internal disturbance type insomnia.

Contents of the invention

In view of the above situation, in order to solve the defects of the prior art, the object of the present invention is to provide a traditional Chinese medicine for treating insomnia of phlegm-heat internal disturbance type, which can effectively solve the medication problem of phlegm-heat internal disturbance type insomnia.

The technical scheme solved by the present invention is that the traditional Chinese medicine is made from the following raw materials: Coptidis 8-12g, Pinellia chinensis 30-60g, Prunella vulgaris 20-30g, Tianzhuhuang 20-30g, Suanzaoren 30-40g, Fushen 10-15g, Zhuru 15-20g, and Shenglongchi 20-30g, mix the above raw materials together, put them into the medicine tank, add water to immerse, soak for 30-60min, decoct with strong fire until boiling, then switch to slow fire decoction Boil for 30 minutes, filter to obtain the filtrate, add water to the filter residue, decoct with strong fire until boiling, then switch to slow fire for 30 minutes, filter to obtain the filtrate, combine the two filtrates, and serve.

The traditional Chinese medicine of the present invention can also be made into dosage forms such as powder, pill, granule, capsule as required.

The invention has rich raw materials, scientific components, reasonable compatibility and mutual support, has the functions of clearing away heat, resolving phlegm, and calming the nerves, and is effectively used for treating insomnia of phlegm-heat internal disturbance type, with good curative effect, safe medication, and no side effects. Innovation in disruptive insomnia drugs.

detailed description

The specific implementation of the present invention will be described in further detail below in conjunction with the examples.

Example 1

When the present invention is implemented, it can be made from the following raw materials: Coptidis 8g, Pinellia chinensis 30g, Prunella vulgaris 20g, Tianzhuhuang 20g, Suanzaoren 30g, Fushen 10g, Zhuru 15g and Shenglong tooth 20g, the above raw materials Mix the medicines together, put them into the medicine tank, add water to immerse, soak for 30-60min, decoct with strong fire until boiling, then switch to simmer for 30min, filter to obtain filtrate, add water to the filter residue, decoct with strong fire until boiling, Use slow fire to decoct for 30 minutes, filter to obtain the filtrate, combine the two filtrates, and serve.

Example 2

When the present invention is actually implemented, it can also be made from the following raw materials: Coptidis 10g, Pinellia 45g, Prunella vulgaris 25g, Tianzhuhuang 25g, Semen jujube 35g, Fushen 12g, Zhuru 18g and Shenglong tooth 25g. Mix the raw materials and drugs together, put them into the medicine tank, add water to immerse, soak for 30-60 minutes, decoct with strong fire until boiling, then switch to slow fire for 30 minutes, filter to obtain filtrate, add water to the filter residue, and decoct with strong fire until boiling , decocted with slow fire for 30 minutes, filtered to obtain the filtrate, combined the two filtrates, and it was ready.

Example 3

When the present invention is actually implemented, it can also be made from the following raw materials: Coptidis 12g, Pinellia 60g, Prunella vulgaris 30g, Tianzhuhuang 30g, Suanzaoren 40g, Fushen 15g, Zhuru 20g and Shenglongtooth 30g. Mix the raw materials and drugs together, put them into the medicine tank, add water to immerse, soak for 30-60 minutes, decoct with strong fire until boiling, then switch to slow fire for 30 minutes, filter to obtain filtrate, add water to the filter residue, and decoct with strong fire until boiling , decocted with slow fire for 30 minutes, filtered to obtain the filtrate, combined the two filtrates, and it was ready.

The prescriptions of the present invention are reasonably compatible and have synergistic effects. In the prescription, coptis clears the heart-fire, Prunella vulgaris clears the liver and heat, jujube seed nourishes the blood and regulates the middle and calms the nerves, Fushen, Fa Pinellia, Zhuru, Tianzhuhuang reduce phlegm and calm the nerves, and dragon teeth can calm the nerves. The combination of various medicines has the functions of clearing away heat, resolving phlegm and calming the nerves. Effectively used to treat intractable insomnia, with good curative effect and safe medication, and has been fully proved by clinical trials. The relevant clinical trial data are as follows:

1 Clinical data

1.1 Case data Select 120 outpatients from Department of Encephalopathy, Henan Provincial Hospital of Traditional Chinese Medicine, and randomly divide them into treatment group and control group, 60 cases each. Among them, there were 40 females and 20 males in the treatment group; the age ranged from 23 to 65 years; the course of disease ranged from 1 to 58 months. The control group consisted of 38 females and 22 males; aged 22 to 65 years; the course of disease was 1 to 60 months. There was no significant difference between the two groups in terms of gender, age, course of disease and other general information ( P > 0.05), and they were comparable.

1.2 Diagnostic criteria

1.2.1 Diagnostic criteria of western medicine It is formulated with reference to the "Classification and Diagnostic Criteria of Mental Disorders in China". ①Prolonged sleep latency: time to fall asleep for more than 30 minutes; ②Sleep maintenance disorder: ≥2 awakenings at night or early morning awakening; ③Deteriorated sleep quality: light sleep, more dreams; ④Total sleep time. Shortening: usually <5h; ⑤ Residual effects during the day: dizziness, lack of energy, drowsiness, fatigue, etc. in the next morning. The above sleep disorders occur at least 3 times a week and last for more than 1 month.

1.2.2 Diagnostic criteria of TCM It is formulated with reference to the TCM industry standard of the People's Republic of China "Standards for Diagnosis and Efficacy of TCM Syndrome". ①Insomnia is the main symptom. In mild cases, it is difficult to fall asleep or to wake up easily, and insomnia after waking up. In severe cases, it is difficult to sleep all night; ②It is often accompanied by headache, dizziness, palpitations, forgetfulness, dreaminess, etc.; Room inspection revealed no abnormalities.

1.2.3 TCM Syndrome Differentiation Criteria The diagnostic criteria for phlegm-heat internal disturbance syndrome were formulated in accordance with the "Guiding Principles for Clinical Research of New Chinese Medicines" issued by the Ministry of Health of the People's Republic of China. Main clinical manifestations: restless sleep, vexation and remorse, chest tightness and abdominal distention, excessive phlegm, dizziness, and bitter mouth. The tongue coating is yellow and greasy, and the pulse is slippery and rapid.

1.2.4 Inclusion criteria: Meet the above diagnostic and syndrome differentiation criteria; age 18-65; sign informed consent.

Exclusion criteria: ① those under 18 years old or over 65 years old; ② pregnant and breastfeeding women; ③ patients with serious primary diseases such as cardiovascular, lung, liver, kidney and hematopoietic system; ④ mentally ill patients; Those who do not take medication as prescribed or have incomplete data, etc., which affect the judgment of curative effect

2 treatment options

2.1 The patients in the control group were given 1-2 mg of Suloazepam Tablets (Estazolam) (manufactured by Hubei Pharmaceutical Co., Ltd., 1 mg per tablet), orally 30 minutes before going to bed.

2.2 Treatment group On the basis of the control group, the traditional Chinese medicine of the present invention was taken orally. Take it once in the morning and evening, 200-300ml each time, avoid strong tea, coffee, and spicy food during treatment. One month was a course of treatment, and the curative effects of the two groups were counted after one course of treatment.

3 Criteria for judging curative effect refer to the "Guiding Principles for Clinical Research of New Chinese Medicines": ①cure: clinical symptoms disappear, sleep time returns to normal or above 6 hours, sleep deeply, and wake up energetically; ②marked effect: clinical symptoms basically disappear, sleep improves obviously, The sleep time increased by more than 3 hours, and the sleep depth increased; ③effective: the symptoms were alleviated, and the sleep time was increased by less than 3 hours; ④ineffective: the insomnia had no obvious improvement after treatment or the symptoms aggravated.

4 Statistical processing All data were processed by SPSS11.0 software, the count data ^were tested by χ2, and the grade data were tested by Ridit.

5 results

The comparison of the clinical efficacy of the two groups of patients is shown in Table 1.

Table 1 Comparison of curative effect between the two groups of patients

group cure markedly effective efficient invalid total effective rate Treatment group (60) 42 12 6 0 100% Control group (60) 16 12 16 16 73.33%

As can be seen from the table above, the treatment group included 60 cases: 42 cases were cured, 12 cases were markedly effective, 6 cases were effective, and 0 cases were ineffective, and the total effective rate was 100%. There were 60 cases in the control group: 16 cases were cured, 12 cases were markedly effective, and 16 cases were effective. 16 cases were ineffective, and the total effective rate was 73.33%. The curative effect comparison between the two groups was analyzed by Ridit, μ=4.24, P<0.01, and the difference was extremely statistically significant.

7 Conclusion

The traditional Chinese medicine of the invention can advance the time of patients falling asleep, prolong the duration of sleep, reduce the number of awakenings per night, increase the total amount of daily sleep, and improve the symptoms of insomnia. Up to 100%, the treatment of phlegm-heat internal disturbance type insomnia has a significant curative effect and has practical clinical significance. It is a major innovation in the treatment of phlegm-heat internal disturbance type insomnia drugs.

Claims (4)

1. A Chinese medicine for treating phlegm-heat internal disturbance type insomnia, characterized in that, the Chinese medicine is made of the following raw materials: Coptidis 8-12g, Pinellia 30-60g, Prunella vulgaris 20-30g, Tianzhuhuang 20- 30g, Suanzaoren 30-40g, Fushen 10-15g, Zhuru 15-20g and Shenglongtooth 20-30g, mix the above raw materials together, put them into the medicine tank, add water to immerse, soak for 30-60min, and fire After decocting until boiling, switch to simmering for 30 minutes, filter to obtain the filtrate, add water to the filter residue, decoct with strong fire until boiling, then switch to simmering for 30 minutes, filter to obtain the filtrate, combine the two filtrates, and serve. 2. The Chinese medicine for treating phlegm-heat internal disturbance type insomnia according to claim 1, characterized in that the Chinese medicine is made of the following raw materials: Coptidis 8g, Pinellia chinensis 30g, Prunella vulgaris 20g, Tianzhuhuang 20g, Ziziphus jujube Ren 30g, Fushen 10g, Zhuru 15g and Shenglongchi 20g, mix the above raw materials together, put them into the medicine tank, add water to immerse, soak for 30-60min, decoct with strong fire until boiling, then switch to slow fire decoction After 30 minutes, filter to obtain the filtrate, add water to the filter residue, decoct with strong fire until boiling, then switch to slow fire for 30 minutes, filter to obtain the filtrate, combine the two filtrates, and serve. 3. The Chinese medicine for treating phlegm-heat internal disturbance type insomnia according to claim 1, characterized in that the Chinese medicine is made of the following raw materials: Coptidis Rhizome 10g, Pinellia 45g, Prunella vulgaris 25g, Tianzhuhuang 25g, Ziziphus jujube Ren 35g, Fushen 12g, Zhuru 18g and Shenglongchi 25g, mix the above raw materials together, put them into the medicine tank, add water to immerse, soak for 30-60min, decoct with strong fire until boiling, then switch to slow fire decoction After 30 minutes, filter to obtain the filtrate, add water to the filter residue, decoct with strong fire until boiling, then switch to slow fire for 30 minutes, filter to obtain the filtrate, combine the two filtrates, and serve. 4. The traditional Chinese medicine for treating phlegm-heat internal disturbance type insomnia according to claim 1, characterized in that the Chinese medicine is made of the following raw materials: 12g of Coptidis Rhizoma, 60g of Pinellia chinensis, 30g of Prunella vulgaris, 30g of Tianzhuhuang, Suanzao Ren 40g, Fushen 15g, Zhuru 20g and Shenglongchi 30g, mix the above raw materials together, put them into the medicine tank, add water to immerse, soak for 30-60min, decoct with strong fire until boiling, then switch to slow fire decoction After 30 minutes, filter to obtain the filtrate, add water to the filter residue, decoct with strong fire until boiling, then switch to slow fire for 30 minutes, filter to obtain the filtrate, combine the two filtrates, and serve.