CN101652470A - 骨髓细胞用于长期培养胰腺胰岛细胞的用途 - Google Patents

骨髓细胞用于长期培养胰腺胰岛细胞的用途 Download PDF

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Publication number
CN101652470A
CN101652470A CN200780049872A CN200780049872A CN101652470A CN 101652470 A CN101652470 A CN 101652470A CN 200780049872 A CN200780049872 A CN 200780049872A CN 200780049872 A CN200780049872 A CN 200780049872A CN 101652470 A CN101652470 A CN 101652470A
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China
Prior art keywords
islet
cell
cells
beta
bone marrow
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Pending
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CN200780049872A
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English (en)
Chinese (zh)
Inventor
罗履广
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Roger Williams Medical Center
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Roger Williams Medical Center
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Publication of CN101652470A publication Critical patent/CN101652470A/zh
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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0676—Pancreatic cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2502/00—Coculture with; Conditioned medium produced by
    • C12N2502/13—Coculture with; Conditioned medium produced by connective tissue cells; generic mesenchyme cells, e.g. so-called "embryonic fibroblasts"
    • C12N2502/1394—Bone marrow stromal cells; whole marrow

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  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Wood Science & Technology (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Diabetes (AREA)
  • Animal Behavior & Ethology (AREA)
  • Cell Biology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Endocrinology (AREA)
  • Emergency Medicine (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Materials For Medical Uses (AREA)
CN200780049872A 2006-11-21 2007-11-20 骨髓细胞用于长期培养胰腺胰岛细胞的用途 Pending CN101652470A (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US86063706P 2006-11-21 2006-11-21
US60/860,637 2006-11-21

Related Child Applications (1)

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CN201410050889.4A Division CN103992982A (zh) 2006-11-21 2007-11-20 骨髓细胞用于长期培养胰腺胰岛细胞的用途

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Publication Number Publication Date
CN101652470A true CN101652470A (zh) 2010-02-17

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Family Applications (2)

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CN200780049872A Pending CN101652470A (zh) 2006-11-21 2007-11-20 骨髓细胞用于长期培养胰腺胰岛细胞的用途
CN201410050889.4A Pending CN103992982A (zh) 2006-11-21 2007-11-20 骨髓细胞用于长期培养胰腺胰岛细胞的用途

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CN201410050889.4A Pending CN103992982A (zh) 2006-11-21 2007-11-20 骨髓细胞用于长期培养胰腺胰岛细胞的用途

Country Status (7)

Country Link
US (1) US20100143306A1 (enExample)
EP (1) EP2092057B1 (enExample)
JP (1) JP5474559B2 (enExample)
CN (2) CN101652470A (enExample)
AU (1) AU2007321983B2 (enExample)
CA (1) CA2670289A1 (enExample)
WO (1) WO2008063640A2 (enExample)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8852934B2 (en) 2010-03-17 2014-10-07 Kyoto University Method of culturing pancreatic islet-like tissues by a tissue complex of pancreas-derived non-endocrinal epithelial cells and vascular endothelial cells
CA3104901A1 (en) * 2018-06-25 2020-01-02 Imagine Pharma, Llc Compositions and methods for propagating insulin-producing islet cells and therapeutic uses thereof
CA3207286A1 (en) * 2021-02-03 2022-08-11 Symbiocelltech, Llc Cell clusters comprising stem and islet cells, methods of making, and treatment of diabetes mellitus therewith

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6001647A (en) * 1994-04-28 1999-12-14 Ixion Biotechnology, Inc. In vitro growth of functional islets of Langerhans and in vivo uses thereof
EP1498478A1 (en) * 2002-04-17 2005-01-19 Otsuka Pharmaceutical Co., Ltd. Method of forming pancreatic beta cells from mesenchymal cells

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Publication number Publication date
AU2007321983B2 (en) 2014-05-29
CA2670289A1 (en) 2008-05-29
EP2092057A4 (en) 2011-04-20
JP2010509936A (ja) 2010-04-02
JP5474559B2 (ja) 2014-04-16
EP2092057B1 (en) 2014-10-15
WO2008063640A3 (en) 2008-12-18
CN103992982A (zh) 2014-08-20
WO2008063640A2 (en) 2008-05-29
EP2092057A2 (en) 2009-08-26
US20100143306A1 (en) 2010-06-10
AU2007321983A1 (en) 2008-05-29

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Application publication date: 20100217