CN101647862A - Antifatigue health care capsules - Google Patents
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Abstract
The invention discloses antifatigue health care capsules. Raw materials prepared into medicinal effective compositions of the health care capsules comprise epimedium extract, ginseng extract, paecilomyces hepialid mycelium fermentation powder, and schisandra extract of which the weight ratio is 6-12:3-8:3-8:1-4. Preferably, the content of icariin in the epimedium extract is more than or equal to 5percent of the total weight of the compositions in the capsules, and the content of panaxoside in the ginseng extract is more than or equal to 1 percent of the total weight of the compositions in thecapsules. The compositions are added with a proper amount of pharmaceutically acceptable additives such as dextrin, starch, hydroxypropyl-beta-cyclodextrin and the like which play roles in drying anddiluting; and the mixture is fully stirred and packaged and molded by a capsule packager. The health care capsules have no toxic or side effect through detection, and have good effect of relieving physical fatigue proved by animal experiments and clinical application.
Description
Technical field
The present invention relates to a kind of health care medicine, specifically a kind of anti-fatigue health-caring capsule.
Background technology
Chinese medicine is thought tired unsoundness fatigue, subhealth state fatigue and the several different stages of development of chronic fatigue syndrome.The muscle power fatigue also claims sports fatigue, and its essence is the property crossed function decline or an imbalance and an asthenia of essence and blood, belongs to physiological, functional, temporary whole serial the variation.Even this state is not taked any measure, by the self regulation of human body self resisting fatigue system, can eliminate voluntarily, so it belongs to physiologic fatigability, health fatigue.
If can not in time eliminate but this health is tired, along with motion such as momental increase, power consumption is felt frustrated and is caused YANG QI deficiency and see spiritlessness and weakness, this i.e. " overexertion leading to consumption of QI ", sweating increases, impairment of body fluid consumption liquid, even deficiency of YIN-blood and see dryness of the mouth and throat, dysphoria with smothery sensation is difficult sleeps; Muscle is fatigued, and spleen is easily impaired, loses in strong fortune and sees the poor appetite lack of appetite, further endogenous damp formation then, the loss of uncomfortable, the symptom of spleen and stomach and body fluid shows the subhealth state fatigue, is also referred to as the intermediateness of physiologic fatigability (physical fatigue) and disease fatigue (fatigue syndrome).
Further developing of this intermediateness will cause the organs function imbalance, the consume of vital essence blood, and particularly the splenic function of the kidney of the congenital foundation and the foundation of acquired constitution is obviously weak, chronic fatigue syndrome occurs, and deficient, the chronic consumptive disease pathological changes of pathological fatigue takes place.
As far back as 20th century 70 to the eighties, the tired serious health problem of developed country that just becomes.The investigation of the U.S. finds, has 14% adult male and women's performance of 20% that tangible fatigue is arranged, and wherein 1/8 can develop into chronic fatigue syndrome.There is nearly 70% people to be in sub-health state in that China is domestic.Though tired do not resemble cancer, the heart disease directly and promptly cause death, it has had a strong impact on people's work and life as a kind of stealthy killer who endangers modern's health.Therefore, the resisting fatigue problem should be given enough attention, and in fact also really increasing people has caused attention to " resisting fatigue problem ".And real respond well anti-fatigue health-caring medicine also needs us to make great efforts to excavate and invention.
Summary of the invention
The present invention's purpose is to disclose a kind of effective anti-fatigue health-caring medicine, to benefit from the society and the public.
The present invention's purpose can take following method to realize:
A kind of anti-fatigue health-caring capsule is characterized in that, the raw material of making active ingredient consists of, Herba Epimedii extract, Radix Ginseng extract, Paecilomyces hepiali Chen et Dai Mycelia yeast powder, Fructus Schisandrae Chinensis extrat; Herba Epimedii extract, Radix Ginseng extract, Paecilomyces hepiali Chen et Dai Mycelia (Cordyceps mycelia powder) yeast powder, the raw material weight ratio of Fructus Schisandrae Chinensis extrat is 6--12: 3--8: 3--8: 1-4.
The present invention's purpose can also take following method to realize:
Described weight ratio is preferably:
Herba Epimedii extract, Radix Ginseng extract, Paecilomyces hepiali Chen et Dai Mycelia yeast powder, the weight ratio of Fructus Schisandrae Chinensis extrat is 9: 6: 6: 3.
Content Determination of Icariin in the described Herba Epimedii extract is 〉=capsule in the constituent gross weight 5%, in the Radix Ginseng extract ginsenoside's content be 〉=capsule in the constituent gross weight 1%.
Be added with the pharmaceutically acceptable additives of dry and diluting effect in the raw material, described additives be following one or more: dextrin, starch, beta-schardinger dextrin-, HP-, microcrystalline Cellulose, micropowder silica gel, hydroxypropyl cellulose, carboxymethylstach sodium.
Herba Epimedii is the Berberidaceae plant, its stem and leaf is China's traditional tonic medicine commonly used, have multiple efficacies such as kidney-replenishing, bone and muscle strengthening, wind-damp dispelling, wherein icariin is one of effective ingredient of invigorating the liver and kidney in the Herba Epimedii, bone and muscle strengthening, all shows physiologically active for improving systema cariovasculare functional, endocrine regulation, enhancing immunity etc.Radix Ginseng is the root of Araliaceae herbaceos perennial Radix Ginseng.Radix Ginseng contains multiple triterpenoid saponin, is generically and collectively referred to as the ginsenoside.Radix Ginseng cures mainly: the deficiency of vital energy desires to take off that disease, deficiency of spleen-QI disease, lung qi are lost deficient syndrome, disease, irritability disease etc. are hindered in gas Tianjin two.Radix Ginseng all has booster action to cerebral cortex process of excitation and process of inhibition, and it is more obvious especially to strengthen process of excitation, so antifatigue effect is arranged.Paecilomyces hepiali Chen et Dai Mycelia contains nutrient substance such as enriching mannitol, adenosine, polysaccharide and each seed amino acid, has the function of expansion trachea, calmness, anti-various antibacterials, blood pressure lowering, can regulate the resistance against diseases of immunologic function, enhancing human body.Fructus Schisandrae Chinensis can improve intellectual activity, improves ability to work, is used for the treatment of the neurasthenia.Fructus Schisandrae Chinensis still is a kind of excited analeptic, can excited spinal cord, and the excitement and the process of inhibition of strengthed condition reflection tend to balance two kinds of processes, thereby improve corticocerebral regulating action.Fructus Schisandrae Chinensis has the analeptic function: enhancing body is to the defence capability of nonspecific stimulation, swimming time that can prolong rats.
Present technique is the center with fatigue, is criterion with the symptom of " void ", is point of penetration with tonification health preserving side, combined with file collecting method and analysis by synthesis method.Cure the square medicine that the illustration of consulting out argumentation fatigue the nationality and fatigue alleviating are prevented and treated subhealth state from last down to 109 ancient times of the Qing Dynasty up to Huangdi's Internal Classics.Nearly 300,000 words relate to all many-sides such as symposium on medical topics, case surplus the illustration 5000, are mainly tired term and tired etiology and pathogenesis, side 1079 head, and nearly 200,000 words are mainly tonification health preserving side.Mainly adopt from history to the Realistic Analysis method, from making a concrete analysis of abstract analysis, excess syndrome combines with canonical parse, and qualitative and quantitative analysis analytical method such as combine draws scientific and reasonable prescription.
So to be raw material add additives by described weight ratio to above active ingredient, is made into capsule,, take for each 2, significantly alleviating physical fatigue by every day 1 time.
The specific embodiment
Embodiment of the present invention are described in further detail below.
Embodiment 1:
A kind of anti-fatigue health-caring capsule is characterized in that, the raw material of making active ingredient consists of, Herba Epimedii extract, Radix Ginseng extract, Paecilomyces hepiali Chen et Dai Mycelia yeast powder, Fructus Schisandrae Chinensis extrat; Herba Epimedii extract, Radix Ginseng extract, Paecilomyces hepiali Chen et Dai Mycelia yeast powder, the raw material weight ratio of Fructus Schisandrae Chinensis extrat is 12: 8: 7: 4.Herba Epimedii extract 120 grams, Radix Ginseng extract 80 grams, Paecilomyces hepiali Chen et Dai Mycelia yeast powder 70 grams, Fructus Schisandrae Chinensis extrat 40 grams; Pharmaceutically acceptable additives dextrin 80 grams.Content Determination of Icariin in the Herba Epimedii extract is 20 grams; Ginsenoside's content is 4 grams in the Radix Ginseng extract.After fully stirring, again through the molding of capsule-packaging machines packing.Every capsule is 0.3 gram, and above-mentioned raw materials adds additives and makes 1300 of capsules altogether.When taking, once a day, each two.
Embodiment 2:
A kind of anti-fatigue health-caring capsule is characterized in that, the raw material of making active ingredient consists of, Herba Epimedii extract, Radix Ginseng extract, Paecilomyces hepiali Chen et Dai Mycelia yeast powder, Fructus Schisandrae Chinensis extrat; Herba Epimedii extract, Radix Ginseng extract, Paecilomyces hepiali Chen et Dai Mycelia yeast powder, the raw material weight ratio of Fructus Schisandrae Chinensis extrat is 6: 3: 4: 1.Herba Epimedii extract 60 grams, Radix Ginseng extract 30 grams, Paecilomyces hepiali Chen et Dai Mycelia yeast powder 40 grams, Fructus Schisandrae Chinensis extrat 10 grams; Pharmaceutically acceptable additives beta-schardinger dextrin-40 grams.Content Determination of Icariin in the Herba Epimedii extract is 9 grams; Ginsenoside's content is 2 grams in the Radix Ginseng extract.After fully stirring, again through the molding of capsule-packaging machines packing.Every capsule is 0.3 gram, and above-mentioned raw materials adds additives and makes 600 of capsules altogether.When taking, once a day, each two.
Embodiment 3:
A kind of anti-fatigue health-caring capsule is characterized in that, the raw material of making active ingredient consists of, Herba Epimedii extract, Radix Ginseng extract, Paecilomyces hepiali Chen et Dai Mycelia yeast powder, Fructus Schisandrae Chinensis extrat; Herba Epimedii extract, Radix Ginseng extract, Paecilomyces hepiali Chen et Dai Mycelia yeast powder, the raw material weight ratio of Fructus Schisandrae Chinensis extrat is 10: 5: 5: 3.Herba Epimedii extract 100 grams, Radix Ginseng extract 50 grams, Paecilomyces hepiali Chen et Dai Mycelia yeast powder 50 grams, Fructus Schisandrae Chinensis extrat 30 grams; Pharmaceutically acceptable additives microcrystalline Cellulose 70 grams.Content Determination of Icariin in the Herba Epimedii extract is 15 grams; Ginsenoside's content is 3 grams in the Radix Ginseng extract.After fully stirring, again through the molding of capsule-packaging machines packing.Every capsule is 0.3 gram, and above-mentioned raw materials adds additives and makes 1000 of capsules altogether.When taking, once a day, each two.
Embodiment 4:
A kind of anti-fatigue health-caring capsule is characterized in that, the raw material of making active ingredient consists of, Herba Epimedii extract, Radix Ginseng extract, Paecilomyces hepiali Chen et Dai Mycelia yeast powder, Fructus Schisandrae Chinensis extrat; Herba Epimedii extract, Radix Ginseng extract, Paecilomyces hepiali Chen et Dai Mycelia yeast powder, the raw material weight ratio of Fructus Schisandrae Chinensis extrat is 9: 6: 6: 3.Herba Epimedii extract 90 grams, Radix Ginseng extract 60 grams, Paecilomyces hepiali Chen et Dai Mycelia yeast powder 60 grams, Fructus Schisandrae Chinensis extrat 30 grams; Pharmaceutically acceptable additives starch 60 grams.Content Determination of Icariin in the Herba Epimedii extract is 15 grams; Ginsenoside's content is 3 grams in the Radix Ginseng extract.After fully stirring, again through the molding of capsule-packaging machines packing.Every capsule is 0.3 gram, and above-mentioned raw materials adds additives and makes 1000 of capsules altogether.When taking, once a day, each two.
Application examples 1
Anti-fatigue health-caring capsule of the present invention has the effect of separating the alleviating physical fatigue function through the animal experiment proof.Concrete test situation is as follows:
One, materials and methods
1. sample: by the capsule that the foregoing description 3 is made, specification is the 0.3g/ grain.With the capsule 's content is given the test agent, is mixed with the enema of desired concn with distilled water.
2. animal and grouping: totally 160 of male mice in kunming, body weight 18-22g is provided by Shanghai Slac Experimental Animal Co., Ltd..Divide 16 groups by body weight with animal, per 4 groups of tests that are used for an index, be that the normal control group is irritated stomach and given distilled water and three dosage groups, irritate stomach respectively and give capsule 's content 0.05g/kgBW/d, 0.10g/kgBW/d, 0.20g/kgBW/d, (be equivalent to respectively human body recommended intake 5 times, 10 times and 20 times).The all edible full nutrition mixed feed of all experimental animals, feed resource: Jiangpu development laboratory animal feed factory, Soviet Union is moving (raises word No. 95001.Animal freely ingests, takes the photograph water.
3. instrument and reagent
1. instrument: swimming case (50cm * 50cm * 40cm), 722 type spectrophotometers, water-bath, stopwatch, SL-1001 type electronic scale.
2. reagent: serum urea measures that test kit, hepatic glycogen are measured test kit, full blood lactic is measured test kit and all built up bio-engineering research institute available from Nanjing, and product batch number is respectively 20051101,20051118 and 20051115.
4. method: by Ministry of Health of the People's Republic of China's " health food function assessment assessment process and method of inspection standard ", swimming with a load attached to the body test in the alleviating physical fatigue functional check method, serum urea are measured (Diacetylmonoxime method), hepatic glycogen and are measured the prescriptive procedure execution that (anthrone method) and blood lactic acid are measured.Irritate gastric capacity 20ml/kgbw/d, every day 1 time, continuous 30 days.
1. swimming with a load attached to the body test: after last is tried thing 30min, put mice and in the swimming case, swim, depth of water 30cm, 25 ℃ of water temperatures, the load sheet lead of 5% body weight of Mus root of the tail portion.The record mice is from the extremely dead time of swimming beginning, as the mice swimming time.
2. serum urea is measured (Diacetylmonoxime method): after last is given sample 30min, be not swimming with a load attached to the body 90min in 30 ℃ ± 0.5 ℃ the water in temperature, behind the rest 60min, pluck eyeball blood sampling 0.8ml (not adding anticoagulant).Treat centrifuging and taking serum behind the blood coagulation, build up carbamide that bio-engineering research produces with Nanjing and measure test kit and measure.
3. hepatic glycogen is measured (anthrone method): last is put to death animal after giving sample 30min, gets the liver stolen goods and builds up the mensuration that test kit description that bio-engineering research produces is carried out hepatic glycogen by Nanjing.
4. blood lactic acid is measured: last gives behind the animal sample 30min with the glass capillary eyeball angular vein 20 μ l that take a blood sample, and builds up the mensuration that full blood lactic mensuration test kit that bio-engineering research produces carries out lactic acid content with Nanjing.Not bearing a heavy burden after the animal blood sampling, is to stop behind the swimming 10min in 30 ℃ ± 0.5 ℃ the water in temperature, and the 20 μ l that take a blood sample immediately measure blood lactic acid, and the 20 μ l that respectively take a blood sample again behind the rest 20min carry out blood lactic acid and measure.
5. data statistics processing method: experiment gained data are carried out comparison between each experimental group with the one factor analysis of variance in the SAS statistical package, use Dunnett ' st to check and carry out the comparison of each test group and matched group.
Two, result
1. body weight: each is organized, and mouse test is initial, the body weight when test mid-term (15d), result of the test (30d) sees Table 1, table 2, table 3.Show that through one factor analysis of variance the equal nonsignificance of difference (P＞0.05) between each dosage group and matched group does not see that capsule 's content is influential to the experimental animal body weight.
The initial body weight (means standard deviation) of each test group mice of table 1
Table 2 test each test group mice body weight (means standard deviation) in mid-term
Table 3 test each test group mice body weight (means standard deviation) in latter stage
2. mice swimming with a load attached to the body test: the results are shown in Table 4, the difference of respectively organizing the swimming with a load attached to the body time average through one factor analysis of variance has utmost point significance (F=7.15, P＜0.01).Through Dunnett ' st check, the average of middle and high dosage group swimming with a load attached to the body time of capsule 's content and normal control group comparing difference have significance (P＜0.05).Illustrate that capsule 's content when the dosage of 0.10g/kgBW/d and 0.20g/kgBW/d, (be equivalent to respectively human body recommended intake 10 times and 20 times), has the effect that prolongs the mice swimming with a load attached to the body time.
Table 4 anti-fatigue health-caring capsule content is to the influence (means standard deviation) of mice swimming with a load attached to the body time
One factor analysis of variance between each test group of a, F=7.15, P＜0.01
* significance is arranged, P＜0.05 with normal control group comparing difference
3. serum urea is measured: each treated animal serum urea measurement result sees Table 5, and the difference of respectively organizing the serum urea average through one factor analysis of variance has utmost point significance (F=8.41, P＜0.01).Through Dunnett ' st check, the middle and high dosage group of capsule 's content carbamide average and normal control group comparing difference have significance (P＜0.05).Illustrate that capsule 's content when the dosage of 0.10g/kgBW/d and 0.20g/kgBW/d, (be equivalent to respectively human body recommended intake 10 times and 20 times), can reduce the generation of motion back mice serum carbamide.
Table 5 anti-fatigue health-caring capsule content is to the influence (means standard deviation) of the back mice serum carbamide that moves
One factor analysis of variance between each test group of a, F=8.41, P＜0.01
* significance is arranged, P＜0.05 with normal control group comparing difference
4. hepatic glycogen is measured: measurement result sees Table 6, and through one factor analysis of variance, the difference of each treated animal hepatic glycogen average has utmost point significance (F=12.39, P＜0.01).Through Dunnett ' st check, the middle and high dosage group of capsule 's content hepatic glycogen average and normal control group comparing difference have significance (P＜0.05).Illustrate that capsule 's content when the dosage of 0.10g/kgBW/d and 0.20g/kgBW/d, (be equivalent to respectively human body recommended intake 10 times and 20 times), has the effect that increases mice glycogen deposit or reduce glycogen use.
Table 6 anti-fatigue health-caring capsule content is to the influence (means standard deviation) of the back Mouse Liver glycogen that moves
One factor analysis of variance between each test group of a, F=12.39, P＜0.01
* significance is arranged, P＜0.05 with normal control group comparing difference
5. blood lactic acid is measured: each organizes mice when quiet, blood lactate level, rest bleeding from anus lactate level and blood lactic acid area under curve see Table 7 at once after the swimming.Through one factor analysis of variance, each organizes the average difference of mice blood lactic acid area under curve does not have significance (F=1.46, P＞0.05).Illustrate that capsule 's content when the dosage of 0.05g/kgBW/d, 0.10g/kgBW/d and 0.20g/kgBW/d, (be equivalent to respectively human body recommended intake 5 times, 10 times and 20 times), do not see obvious influence to the generation of the back mice blood lactic acid that moves.
Table 7 anti-fatigue health-caring capsule content is to the influence (means standard deviation) of mice swimming bleeding from anus lactate level and blood lactic acid area under curve
Blood lactic acid before the A swimming; At once blood lactic acid after the B swimming; The blood lactic acid of C swimming back rest 20min
One factor analysis of variance between each test group of a, F=1.46, P＞0.05
Three, conclusion
1. through irritating stomach when giving the dosage of mice 0.05g/kgBW/d, 0.10g/kgBW/d and 0.20g/kgBW/d capsule 's content (be equivalent to respectively human body recommended intake 5 times, 10 times and 20 times), the body weight of experiment mice is not seen obvious influence.
2. mice swimming with a load attached to the body result of the test shows, the capsule 's content that tries when the dosage of 0.05g/kgBW/d, 0.10g/kgBW/d and 0.20g/kgBW/d (be equivalent to respectively human body recommended intake 5 times, 10 times and 20 times), have the effect that prolongs the mice swimming with a load attached to the body time.
3. the serum urea measurement result shows, the capsule 's content that tries when the dosage of 0.05g/kgBW/d, 0.10g/kgBW/d and 0.20g/kgBW/d (be equivalent to respectively human body recommended intake 5 times, 10 times and 20 times), can reduce the generation of motion back mice serum carbamide.
4. hepatic glycogen mensuration measurement result shows, the capsule 's content that tries when the dosage of 0.05g/kgBW/d, 0.10g/kgBW/d and 0.20g/kgBW/d (be equivalent to respectively human body recommended intake 5 times, 10 times and 20 times), have the effect that increases mice glycogen deposit or reduce glycogen use.
5. blood lactic acid measurement result shows, the capsule 's content that tries when the dosage of 0.05g/kgBW/d, 0.10g/kgBW/d and 0.20g/kgBW/d (be equivalent to respectively human body recommended intake 5 times, 10 times and 20 times), obvious influence is not seen in the generation of the back mice blood lactic acid that moves.
According to the criterion of " alleviating physical fatigue functional check method " in " health food function assessment assessment process and method of inspection standard ", inspected antifatigue capsule has the effect of alleviating physical fatigue function.
In addition, this anti-fatigue health-caring capsule detects through health food safety toxicology, and testing result is nontoxic level for the anti-fatigue health-caring capsule content belongs to.
Application examples 2
Health-caring capsule clinical trial of the present invention:
Patient's 100 examples such as chronic tired out and drowsiness, sexual hypofunction, headache, dizzy, dim eyesight, joint aches, myasthenia of limbs, impermanent memory are bad, forgetful, absent minded, age 25-55 year.Take embodiment 4 antifatigue capsules, once a day, each two.The back improvement of three weeks is taken 5-8 week, symptom complete obiteration person 91 people, the person of having clear improvement 9 people continuously.Cure rate reaches 91%, and total effective rate reaches 100%.This anti-fatigue health-caring capsule, without any side effects.
Claims (4)
1, a kind of anti-fatigue health-caring capsule is characterized in that, the raw material of making active ingredient consists of, Herba Epimedii extract, Radix Ginseng extract, Paecilomyces hepiali Chen et Dai Mycelia yeast powder, Fructus Schisandrae Chinensis extrat; Herba Epimedii extract, Radix Ginseng extract, Paecilomyces hepiali Chen et Dai Mycelia yeast powder, the raw material weight ratio of Fructus Schisandrae Chinensis extrat is 6--12: 3--8: 3--8: 1-4.
2,, anti-fatigue health-caring capsule according to claim 1, it is characterized in that, Herba Epimedii extract, Radix Ginseng extract, Paecilomyces hepiali Chen et Dai Mycelia yeast powder, the raw material weight ratio of Fructus Schisandrae Chinensis extrat is 9: 6: 6: 3.
3, anti-fatigue health-caring capsule according to claim 1 and 2, it is characterized in that, content Determination of Icariin in the described Herba Epimedii extract is 〉=capsule in the constituent gross weight 5%, in the Radix Ginseng extract ginsenoside's content be 〉=capsule in the constituent gross weight 1%.
4, according to claim 1,2 or 3 described anti-fatigue health-caring capsules, it is characterized in that, add the pharmaceutically acceptable additives that drying and diluting effect have been arranged in the raw material of active ingredient, described additives be following one or more: dextrin, starch, beta-schardinger dextrin-, HP-, microcrystalline Cellulose, micropowder silica gel, hydroxypropyl cellulose, carboxymethylstach sodium.
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Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102919845A (en) * | 2012-11-21 | 2013-02-13 | 济南老来寿生物股份有限公司 | Health-care food for relieving physical fatigue |
| CN103549415A (en) * | 2013-10-24 | 2014-02-05 | 北京一品堂医药科技有限公司 | Composition with biological traditional Chinese medicinal prescription for relieving fatigue, invigorating the kidney and strengthening yang, traditional Chinese medicinal preparation, preparation method and application thereof |
| CN103609786A (en) * | 2013-10-31 | 2014-03-05 | 安徽博格生物科技有限公司 | Tea bag capable of preventing chronic fatigue syndrome and preventing sudden death |
| CN104013716A (en) * | 2014-05-20 | 2014-09-03 | 绿健园（新乡）生物工程有限公司 | Maca tablet |
| CN107095304A (en) * | 2017-07-12 | 2017-08-29 | 延边韩工坊健康制品有限公司 | One kind alleviates physical fatigue health food and preparation method thereof |
| CN107823250A (en) * | 2017-11-15 | 2018-03-23 | 广东旭东号生物技术有限公司 | A kind of Chinese medicine health-care pharmaceutical formulation and preparation method with inrigorating qi and promoting blood circulation, alleviation physical fatigue effect |
-
2008
- 2008-08-15 CN CN2008101202912A patent/CN101647862B/en not_active Expired - Fee Related
Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102919845A (en) * | 2012-11-21 | 2013-02-13 | 济南老来寿生物股份有限公司 | Health-care food for relieving physical fatigue |
| CN103549415A (en) * | 2013-10-24 | 2014-02-05 | 北京一品堂医药科技有限公司 | Composition with biological traditional Chinese medicinal prescription for relieving fatigue, invigorating the kidney and strengthening yang, traditional Chinese medicinal preparation, preparation method and application thereof |
| CN103549415B (en) * | 2013-10-24 | 2015-04-29 | 北京一品堂医药科技有限公司 | Composition with biological traditional Chinese medicinal prescription for relieving fatigue, invigorating the kidney and strengthening yang, traditional Chinese medicinal preparation, preparation method and application thereof |
| CN103609786A (en) * | 2013-10-31 | 2014-03-05 | 安徽博格生物科技有限公司 | Tea bag capable of preventing chronic fatigue syndrome and preventing sudden death |
| CN104013716A (en) * | 2014-05-20 | 2014-09-03 | 绿健园（新乡）生物工程有限公司 | Maca tablet |
| CN107095304A (en) * | 2017-07-12 | 2017-08-29 | 延边韩工坊健康制品有限公司 | One kind alleviates physical fatigue health food and preparation method thereof |
| CN107823250A (en) * | 2017-11-15 | 2018-03-23 | 广东旭东号生物技术有限公司 | A kind of Chinese medicine health-care pharmaceutical formulation and preparation method with inrigorating qi and promoting blood circulation, alleviation physical fatigue effect |
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| Publication number | Publication date |
|---|---|
| CN101647862B (en) | 2012-06-27 |
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