CN101642502A - Male moth yang-strengthening compound preparation formula and preparation technique thereof - Google Patents
Male moth yang-strengthening compound preparation formula and preparation technique thereof Download PDFInfo
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Abstract
The invention discloses a male moth yang-strengthening compound preparation formula and a preparation technique thereof. The male moth yang-strengthening compound preparation formula comprises the following components, by weight percent: 25-35% of male moth, 20-25% of herba epimedii, 10-20% of prepared rehmannia root, 8-12% of cinnamon, 2-5% of Chinese dodder, 2-5% of eucommia bark, 2-5% of aweto,2-5% of angelica and 2-5% of licorice; the preparation technique comprises the following steps: putting the male moth into a baking oven for drying, adding alcohol after removing impurities and proportioning with other materials, then extracting by ultrasonic waves, removing the alcohol from extracting liquid, obtaining raw material powder and pressing into tablets. The invention has the advantages that the invention utilizes traditional Chinese medicines with medicine and food isogeny as raw materials to carry out reasonable matching so as to prepare a health-care food, avoids drug resistance and toxic or side effect caused by western medicines and achieves the function of functional treatment on the basis of scientific and healthy diet.
Description
Technical field
The present invention relates to male moth yang-strengthening compound preparation formula and manufacturing process thereof, products obtained therefrom is mainly used in rapid raising body serum NO levels, performance NO different physiological roles, particularly improve blood flow to the genital orgnas,male, cause the diastole of cavernous body of penis smooth muscle tissue, help the sexual dysfunction patient to recover normal penile erectile function.
Background technology
1998, the physiologist of three greatnesses (the Robert F Furchgott of the state university in USA New York, the Louis J Ignarro of University of California-Los Angeles and the Freed Murad of University of Texas) is climbed up the podium of Nobel's medical physiology prize simultaneously, their contribution be the physiological action of having found nitric oxide (NO) (though side morning. viagra is good, not as natural [J] medical world, 2008 (4): 90-92).A large amount of experimentatioies confirms that NO satisfies all as the neurohumoral condition of inducing erection, is arranged in the neurocyte of domination penis smooth muscle; Some research worker have successfully been induced erection (Wu Dapeng with NO donor direct injection in the animal cavernous body of penis, Li Yonghai. nitric oxide and synzyme thereof and erection regulation and control [J] " foreign medical science " urinary system fascicle, 1997,17 (4): 151-153), the formation that suppresses NO can suppress by stimulating the neural caused erection of penis.
" father of viagra " tells us: " nitrogen oxide is healthy key, and obtains diet and the exercise that nitric oxide production key is a science health ".The ideal medicament of adjusting NO is just being attempted to develop for clinical use by some famous drugmakers.Being worth mentioning is, at present by the Alibra of medium " quick-fried " " viagra (Viagra) ", claims in the marketing advertisement: be " first is by the oral Alibra of NO-cGMP path in the world ".Analyze from pharmacological mechanism: it is the activity by the phosphodiesterase that suppresses degraded cGMP, and the effect that prolongs cGMP reaches the vasodilator effect.And be not truly nitric oxide donors.Because cGMP is the second message,second messenger of wide participation body physiological function regulation and control, therefore, viagra has its untoward reaction unavoidably in anti-sexual impotence.So far having had over one hundred at least people to die from from its appearance takes viagra, wherein has to belong to the cardiac more than 60%.Admitted by official at present and side effect that have certain universality has: headache: find have 13% the people back of taking medicine headache to occur approximately in the clinical trial, and one or two people's severe headache, and taking dose is big more, and headache is more violent.Dim eyesight: have 3% pill taker that of short duration blurred vision can take place approximately, the hallucination that blue light also can occur seeing that has.Swoon: this medicine has the effect that causes the blood pressure rapid drawdown, if take medicines such as nitroglycerin simultaneously, often can produce the giddy even the symptom of falling in a swoon immediately.Priapism: urethritis, leukemic man are arranged, can not erect for a long time after taking, the result will injure pudendum muscular tissue, in addition increase the weight of sexual impotence (though side morning. viagra is good, not as natural [J] medical world, 2008 (4): 90-92).
Summary of the invention
The object of the present invention is to provide male moth yang-strengthening compound preparation formula and manufacturing process thereof, can effectively solve the problem that there is serious toxic and side effects in existing Yang invigorating medicine.
In order to solve the problems of the technologies described above, the present invention is achieved by the following technical solutions: male moth yang-strengthening compound preparation formula, comprise following component, and the each component percentage by weight is: male moth: 25%-35%, Herba Epimedii: 20%-25%, Radix Rehmanniae Preparata: 10%-20%, Cortex Cinnamomi: 8%-12%, Semen Cuscutae 2%-5%, the Cortex Eucommiae: 2%-5%, Cordyceps: 2%-5%, Radix Angelicae Sinensis: 2%-5%, Radix Glycyrrhizae: 2%-5%.
Preferably, male moth: 30%, Herba Epimedii: 20%, Radix Rehmanniae Preparata: 20%, Cortex Cinnamomi: 10%, Semen Cuscutae 4%, the Cortex Eucommiae: 4%, Cordyceps: 4%, Radix Angelicae Sinensis: 4%, Radix Glycyrrhizae: 4%.
Preferably, male moth: 25%, Herba Epimedii: 25%, Radix Rehmanniae Preparata: 15%, Cortex Cinnamomi: 10%, Semen Cuscutae 5%, the Cortex Eucommiae: 5%, Cordyceps: 5%, Radix Angelicae Sinensis: 5%, Radix Glycyrrhizae: 5%.
Preferably, male moth: 35%, Herba Epimedii: 23%, Radix Rehmanniae Preparata: 10%, Cortex Cinnamomi: 12%, Semen Cuscutae 4%, the Cortex Eucommiae: 4%, Cordyceps: 4%, Radix Angelicae Sinensis: 4%, Radix Glycyrrhizae: 4%.
Adopt the manufacturing process of above-mentioned male moth yang-strengthening compound preparation formula to be: to may further comprise the steps successively:
A. the male live body Bombycis mori of silkworm is put into 70 ℃ of oven dryings, remove impurity such as hair, wing then;
B. male moth in the steps A and other materials are weighed by formula proportion, put into Chinese medicine grinder and be crushed to the 10-40 order;
C. add ethanol, then ultrasonic extraction: alcohol concentration 40-70%, the weight ratio of feed liquid is 1: 5-10,30 minutes to 4 hours extraction time, extract 40-60 ℃ of temperature, ultrasonic power: 900-1100W obtains extracting solution and filtering residue;
D. the extracting solution that step C is produced revolves and boils off except that ethanol, concentrates the freezing or spray drying in back, obtains raw material powder, and perhaps directly adopting nitrogen is that the closed cycle spray drying of medium obtains raw material powder;
E. the above-mentioned raw materials powder is made tablet by the tablet machine tabletting.
Preferably, male silkworm moth is copulation live body not in the described steps A; Guarantee the property of medicine preferably.
Preferably, alcohol concentration 50% among the described step C, and extraction time is 2 hours, and extracting temperature is 50 ℃, ultrasonic power 1000W; Can reach the technological parameter of better effects.
Compared with prior art, advantage of the present invention is: utilize integration of edible and medicinal herbs Chinese medicine to make health food for raw material carries out reasonable compatibility, drug resistance that Western medicine brought and toxic and side effects have been avoided, on science health diet basis, reach the functional therapeutic effect, the present invention is directed to sexual dysfunction patient penis can't this shortcoming of normal erection, as the NO donor, improve patients serum's NO concentration (15min) rapidly, promote the diastole of cavernous body of penis smooth muscle tissue, persistent period is 30min to 60min in body, has good tonifying YANG effect.
Description of drawings
Fig. 1 is 4.0gkg
-1ZY to the influence curve figure of mice serum NO content;
Fig. 2 is 1.0gkg
-1ZY to the influence curve figure of mice serum NO content;
Fig. 3 is 0.5gkg
-1ZY to the influence curve figure of mice serum NO content;
Fig. 4 is 0.25gkg
-1ZY to the influence curve figure of mice serum NO content;
Fig. 5 is 0.125gkg
-1ZY to the influence curve figure of mice serum NO content;
Fig. 6 is 16gkg
-1ZY to the variation diagram that influences of male mice body weight;
Fig. 7 is 16gkg
-1ZY to the variation diagram that influences of female mice body weight.
The specific embodiment
Embodiment one:
Male moth yang-strengthening compound preparation formula comprises following component, and the each component percentage by weight is: male moth: 30%, and Herba Epimedii: 20%, Radix Rehmanniae Preparata: 20%, Cortex Cinnamomi: 10%, Semen Cuscutae 4%, the Cortex Eucommiae: 4%, Cordyceps: 4%, Radix Angelicae Sinensis: 4%, Radix Glycyrrhizae: 4%.
Embodiment two:
Male moth yang-strengthening compound preparation formula comprises following component, and the each component percentage by weight is: male moth: 25%, and Herba Epimedii: 25%, Radix Rehmanniae Preparata: 15%, Cortex Cinnamomi: 10%, Semen Cuscutae 5%, the Cortex Eucommiae: 5%, Cordyceps: 5%, Radix Angelicae Sinensis: 5%, Radix Glycyrrhizae: 5%.
Embodiment three:
Male moth yang-strengthening compound preparation formula comprises following component, and the each component percentage by weight is: male moth: 35%, and Herba Epimedii: 23%, Radix Rehmanniae Preparata: 10%, Cortex Cinnamomi: 12%, Semen Cuscutae 4%, the Cortex Eucommiae: 4%, Cordyceps: 4%, Radix Angelicae Sinensis: 4%, Radix Glycyrrhizae: 4%.
Adopt the manufacturing process of above three kinds of embodiment male moth yang-strengthening compound preparation formulas to be: to may further comprise the steps successively: A.. puts into 70 ℃ of oven dryings with the male live body Bombycis mori of silkworm, removes impurity such as hair, wing then; B. male moth in the steps A and other materials are weighed by formula proportion, put into Chinese medicine grinder and be crushed to the 10-40 order; C. add ethanol, then ultrasonic extraction: alcohol concentration 40-70%, the weight ratio of feed liquid is 1: 5-10,30 minutes to 4 hours extraction time, extract 40-60 ℃ of temperature, ultrasonic power: 900-1100W obtains extracting solution and filtering residue; D. the extracting solution that step C is produced revolves and boils off except that ethanol, concentrates the freezing or spray drying in back, obtains raw material powder, and perhaps directly adopting nitrogen is that the closed cycle spray drying of medium obtains raw material powder; E. the above-mentioned raw materials powder is made tablet by the tablet machine tabletting.
Male moth yang-strengthening sheet preparation technology: above-mentioned gained raw material powder is made tablet by the tablet machine tabletting, every heavy 0.5g.Effective dose: male moth: 3.75-7.5mg/kg, Herba Epimedii: 2.5-5.0mg/kg, Radix Rehmanniae Preparata: 2.5-5.0mg/kg, Cortex Cinnamomi: 1.25-2.5mg/kg, Semen Cuscutae 0.5-1.0mg/kg, the Cortex Eucommiae: 0.5-1.0mg/kg, Cordyceps: 0.5-1.0mg/kg, Radix Angelicae Sinensis: 0.5-1.0mg/kg, Radix Glycyrrhizae: 0.5-1.0mg/kg.
Using method: warm water takes, and the low alcohol consumption effect is better, the 2-3 sheet/time.
Below be that the medicament that adopts this explained hereafter is carried out the pharmacological effect experiment, this experiment is entrusted Zhejiang University of Traditional Chinese Medicine Animal Experimental Study center to finish pharmacodynamics and is detected;
1. test objective
By to the influence of NO content in mice serum and cerebral tissue experiment, the drug action of this product of preliminary observation gives this product by high dose repeatedly, observes its toxic action and maximum tolerated dose.
2. be subjected to the reagent thing
2.1 trial drug
2.1.1 be subjected to the reagent thing, character: chocolate brown powder, numbering: ZY, lot number: 20081111, storage procedures: lucifuge, drying, room temperature (below 25 ℃) are preserved, compound method: face with preceding under aseptic condition with 0.9% physiological saline solution to desired concn.
3. experimental animal
Cultivars and strains: the ICR mice, rank: the SPF level, sex: male, female, body weight: 18-22g, source: Shanghai Experimental Animal Center/Shanghai Slac Experimental Animal Co., Ltd. of the Chinese Academy of Sciences [production licence: SCXK (Shanghai) 2007-0005].
4. experiment condition
Barrier system experiment receptacle, temperature: 22 ± 1 ℃, humidity: 50-70%, illumination: 150-200Lx, light and shade replaced in 12 hours, noise＜50dB, occupancy permit: SYXK (Zhejiang) 2008-0115.Drinking-water: the tap water filter sterilization places autoclaved drinking-water bottle freely to drink.Feedstuff: full nutrition pellet.Feeding manner: free diet, give competent feedstuff and water in the mice rearging cage, every cage is raised 5 mices, and before the test, every mice is weighed, marker number.
5. reagent and instrument
5.1 reagent and test kit
5.1.1 sodium chloride injection, the 250ml/ bottle, content 0.9%, by Shapuaisi Pharmaceutical Co., Ltd., Pinghu City, Zhejiang Prov., lot number is 070401-4;
5.1.2 nitric oxide (NO) test kit builds up biotechnology research by Nanjing and is produced, lot number 20081025.
5.2 instrument and equipment
5.2.1AG204-electronic analytical balance, Switzerland METTLER company;
5.2.2JY6001 type mice electronic scale, last hamming bridge exact science instrument company;
5.2.3VARIOSKAN the multi-functional microplate reader of FLASH, U.S. Thermo company.
6. grouping and administration
6.1 dosage
6.1.1 blank group: Isodose normal saline;
6.1.2 test one: ZY 4gkg
-1
6.1.3 test two: ZY 1gkg
-1
6.1.4 test three: ZY 0.5gkg
-1
6.1.5 test four: ZY 0.25gkg
-1
6.1.6 test five: ZY 0.125gkg
-1
6.1.7 test six: ZY 16gkg
-1
6.2 route of administration
Per os is irritated helmet.
7. test method
7.1 various dose ZY is to the influence of NO content in mice serum and the cerebral tissue
Get the SPF level ICR mice of body weight 18～20g, male, wherein administration group its mouse oral is irritated the ZY of stomach corresponding dosage, when 15min, 30min after the administration, 45min, 60min, 90min, 120min, 150min, 180min, 240min, 300min and 360min, each time point is got 12 mices respectively, and the eye socket vein is got blood; Other gets 12 mices and does the blank group, after per os is irritated stomach corresponding dosage normal saline, the eye socket vein is got blood and is got cerebral tissue, and cerebral tissue is with 4 ℃ of normal saline flushings, after filter paper blots the cerebral tissue surface moisture, 10% brain tissue homogenate's liquid is made in homogenate, after blood placed 4 ℃ of refrigerator 30min, the centrifugal 10min of 3000rpm got serum, with NO content in NO kit measurement serum and the cerebral tissue, measure the cerebral tissue protein content with Kao Masi light blue method.
7.2 observe ZY to chmice acute toxic reaction (maximum tolerance determination).
Get 80 of the SPF level ICR mices of body weight 18～20g, male and female half and half are divided into ZY group and blank group at random by body weight respectively, and each group is 40, respectively 20 of male and female.(evening before that day, 9:00 began fasting, 9:00 test in morning next day) can't help water 12 hours in fasting before the administration.Single-dose capacity mice is the 0.4ml/10g body weight.At once observe the response situation of animal after the administration, comprise that animal appearance, behavioral activity, the mental status, appetite, defecation and color thereof, fur, nose, eye, mouth have or not abnormal secretion thing and death condition, the timely postmortem of dead animal is if the ill dirty device of perusal then carries out histopathologic examination.And administration the 1st day observed 1 time every 30 minutes to 1 hour, observed later every day 1 time, observed the reaction of record animal toxicity, body weight change and dead distribution situation continuously 14 days.With body weight change, reaction and death condition, the overall merit result of the test draws the ZY maximum tolerated dose oral to mice.If above dosage animal occurs dead, carry out corresponding acute toxicity test again according to dead degree.All animals are put to death in off-test, cut open inspection and do perusal, if the ill dirty device of perusal then carries out histopathologic examination, with general reaction, body weight, death and pathologic finding overall merit result of the test.
8. observation index
NO content in serum and the cerebral tissue; Metamorphosis after the administration of chmice acute toxic reaction experimental observation mice is measured body weight.
9. date processing
Carry out statistical analysis with SPSS11.5 software, (X ± S) expression, measurement data is used t test evaluation result of the test to all data with mean ± standard deviation.
10. result of the test
10.14gkg
-1ZY is to the influence of mice serum NO content
By table 1 and Fig. 1 result as seen, with the blank group relatively, mouse stomach gives 4gkg
-1ZY after, serum NO content sharply raises (P＜0.01), 15min mice serum NO content rises to the highlyest after the administration, mice passing serum NO content in time slowly descends subsequently, but still is significantly higher than blank group (P＜0.01).
Table 1 4gkg
-1ZY to the influence of mice serum NO content (X ± s, n=10)
Annotate: with blank group comparable group, * P＜0.05, * * P＜0.01.
10.2 1gkg
-1ZY is to the influence of mice serum NO content
By table 2 and Fig. 2 result as seen, with the blank group relatively, mouse stomach gives 1gkg
-1ZY after, NO content sharply raise (P＜0.01 or P＜0.05) in the 15min-90min mice serum after the administration, 15min mice serum NO content rises to the highest after the administration, mice passing serum NO content in time slowly descends subsequently, behind the administration 150min in the mice serum NO content return to the level of blank group mice.
Table 2 1gkg
-1ZY to the influence of mice serum NO content (X ± s, n=10)
Annotate: with blank group comparable group, * P＜0.05, * * P＜0.01.
10.3 0.5gkg
-1ZY is to the influence of NO content in mice serum and the cerebral tissue
By table 3 and Fig. 3 result as seen, with the blank group relatively, mouse stomach gives 0.5gkg
-1ZY after, NO content sharply raise (P＜0.01 or P＜0.05) in the 15min-90min mice serum after the administration, 15min mice serum NO content rises to the highest after the administration, mice passing serum NO content in time slowly descends subsequently, behind the administration 120min in the mice serum NO content return to the level of blank group mice.After the administration, NO content does not have significant change (P＞0.05) in the mouse brain tissue.
Table 3ZY (0.5gkg
-1) to the influence of NO content in mice serum and the cerebral tissue (X ± s, n=10)
Annotate: with blank group comparable group, * P＜0.05, * * P＜0.01.
10.4 0.25gkg
-1ZY is to the influence of NO content in mice serum and the cerebral tissue
By table 4 and Fig. 4 result as seen, with the blank group relatively, mouse stomach gives 0.25gkg
-1ZY after, NO content sharply raise (P＜0.01 or P＜0.05) in the 15min-30min mice serum after the administration, 15min mice serum NO content rises to the highest after the administration, mice passing serum NO content in time slowly descends subsequently, behind the administration 60min in the mice serum NO content return to the level of blank group mice.After the administration, NO content does not have significant change (P＞0.05) in the mouse brain tissue.
Table 4ZY (0.25gkg
-1) to the influence of NO content in mice serum and the cerebral tissue (X ± s, n=10)
Annotate: with blank group comparable group, * P＜0.05, * * P＜0.01.
10.5 0.125gkg
-1ZY is to the influence of NO content in mice serum and the cerebral tissue
By table 5 and Fig. 5 result as seen, with the blank group relatively, mouse stomach gives 0.125gkg
-1ZY after, after the administration in the 15min mice serum NO content obviously raise (P＜0.01), NO content descends in the mice serum subsequently, behind the administration 30min in the mice serum NO content return to the level of blank group mice.After the administration, NO content does not have significant change (P＞0.05) in the mouse brain tissue.
Table 5ZY (0.125gkg
-1) to the influence of NO content in mice serum and the cerebral tissue (X ± s, n=10)
Annotate: with blank group comparable group, * P＜0.05, * * P＜0.01.
10.6 ZY 16gkg
-1To chmice acute toxic reaction (maximum tolerance determination)
Mice single gastric infusion gives the ZY of 16g/kg, and in the administration 180min, obvious adverse reaction does not appear in mice.14 days viewing durations, the animal body weight average increases with the prolongation of test period, and it is dead not see that animal occurs.By Fig. 6,7 results as seen, compare with the blank group, ZY group male mice body weight after administration slightly is lighter than blank, but no significant difference (P＞0.05); ZY group female mice is also no significant difference (P＞0.05) of body weight during after the administration 14 days.
10. conclusion
Above result of the test shows that mouse stomach gives 4gkg
-1ZY after, serum NO content sharply raises (P＜0.01), 180min mice serum NO content after the administration but still be significantly higher than blank group (P＜0.01).Mouse stomach gives 1gkg
-1ZY after, after the administration in the 15min-90min mice serum NO content sharply raise (P＜0.01 or P＜0.05), behind the administration 150min in the mice serum NO content return to the level of blank group mice.Mouse stomach gives 0.5gkg
-1ZY after, after the administration in the 15min-90min mice serum NO content sharply raise (P＜0.01 or P＜0.05), behind the administration 120min in the mice serum NO content return to the level of blank group mice.Mouse stomach gives 0.25gkg
-1ZY after, after the administration in the 15min-30min mice serum NO content sharply raise (P＜0.01 or P＜0.05), behind the administration 60min in the mice serum NO content return to the level of blank group mice.Mouse stomach gives 0.125gkg
-1ZY after, after the administration in the 15min mice serum NO content obviously raise (P＜0.01), behind the administration 30min in the mice serum NO content return to the level of blank group mice.Mice is irritated helmet and gives 0.125-0.5gkg
-1ZY after, NO content does not have significant change (P＞0.05) in the mouse brain tissue.Can effectively the raise effect of NO concentration in the mouse blood of ZY, its effect and its dosage have certain dependence, and after the administration in the blood time that returns to the normal mouse level of NO concentration and dosage certain dependence is arranged.When dosage increases to 16gkg
-1, mice there is no obvious adverse reaction behind the multiple dosing, illustrates that ZY does not have obvious toxic-side effects.
The above only is specific embodiments of the invention, but technical characterictic of the present invention is not limited thereto, and any those skilled in the art is in the field of the invention, and the variation of being done or modify all is encompassed among the claim of the present invention.
Claims (7)
1. male moth yang-strengthening compound preparation formula, it is characterized in that: comprise following component, the each component percentage by weight is: male moth: 25%-35%, Herba Epimedii: 20%-25%, Radix Rehmanniae Preparata: 10%-20%, Cortex Cinnamomi: 8%-12%, Semen Cuscutae 2%-5%, the Cortex Eucommiae: 2%-5%, Cordyceps: 2%-5%, Radix Angelicae Sinensis: 2%-5%, Radix Glycyrrhizae: 2%-5%.
2. male moth yang-strengthening compound preparation formula as claimed in claim 1 is characterized in that: male moth: 30%, and Herba Epimedii: 20%, Radix Rehmanniae Preparata: 20%, Cortex Cinnamomi: 10%, Semen Cuscutae 4%, the Cortex Eucommiae: 4%, Cordyceps: 4%, Radix Angelicae Sinensis: 4%, Radix Glycyrrhizae: 4%.
3. male moth yang-strengthening compound preparation formula as claimed in claim 1 is characterized in that: male moth: 25%, and Herba Epimedii: 25%, Radix Rehmanniae Preparata: 15%, Cortex Cinnamomi: 10%, Semen Cuscutae 5%, the Cortex Eucommiae: 5%, Cordyceps: 5%, Radix Angelicae Sinensis: 5%, Radix Glycyrrhizae: 5%.
4. male moth yang-strengthening compound preparation formula as claimed in claim 1 is characterized in that: male moth: 35%, and Herba Epimedii: 23%, Radix Rehmanniae Preparata: 10%, Cortex Cinnamomi: 12%, Semen Cuscutae 4%, the Cortex Eucommiae: 4%, Cordyceps: 4%, Radix Angelicae Sinensis: 4%, Radix Glycyrrhizae: 4%.
5. adopt the manufacturing process of the described male moth yang-strengthening compound preparation formula of claim 1, it is characterized in that: may further comprise the steps successively:
A. the male live body Bombycis mori of silkworm is put into 70 ℃ of oven dryings, remove impurity such as hair, wing then;
B. male moth in the steps A and other materials are weighed by formula proportion, put into Chinese medicine grinder and be crushed to the 10-40 order;
C. add ethanol, then ultrasonic extraction: alcohol concentration 40-70%, the weight ratio of feed liquid is 1: 5-10,30 minutes to 4 hours extraction time, extract 40-60 ℃ of temperature, ultrasonic power: 900-1100W obtains extracting solution and filtering residue;
D. the extracting solution that step C is produced revolves and boils off except that ethanol, concentrates the freezing or spray drying in back, obtains raw material powder, and perhaps directly adopting nitrogen is that the closed cycle spray drying of medium obtains raw material powder;
E. the above-mentioned raw materials powder is made tablet by the tablet machine tabletting.
6. as male moth yang-strengthening compound preparation manufacturing process as described in the claim 5, it is characterized in that: male silkworm moth is copulation live body not in the described steps A.
7. as male moth yang-strengthening compound preparation manufacturing process as described in the claim 5, it is characterized in that: alcohol concentration 50% among the described step C, and extraction time is 2 hours, and extracting temperature is 50 ℃, ultrasonic power 1000W.
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104432286A (en) * | 2014-10-31 | 2015-03-25 | 广西象州华佳蚕种场有限公司 | Method for removing lepis wings of male silkworm moths |
| CN109498746A (en) * | 2018-12-21 | 2019-03-22 | 周多强 | A kind of Chinese materia medica preparation and preparation method thereof for treating diabetic men sex dysfunction |
| CN115067496A (en) * | 2022-03-28 | 2022-09-20 | 海口嘉丰生物科技有限公司 | Pure natural product medical health-preserving health-care product composition and preparation method thereof |
-
2009
- 2009-09-03 CN CN2009101018389A patent/CN101642502B/en not_active Expired - Fee Related
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104432286A (en) * | 2014-10-31 | 2015-03-25 | 广西象州华佳蚕种场有限公司 | Method for removing lepis wings of male silkworm moths |
| CN109498746A (en) * | 2018-12-21 | 2019-03-22 | 周多强 | A kind of Chinese materia medica preparation and preparation method thereof for treating diabetic men sex dysfunction |
| CN115067496A (en) * | 2022-03-28 | 2022-09-20 | 海口嘉丰生物科技有限公司 | Pure natural product medical health-preserving health-care product composition and preparation method thereof |
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