CN101637441B - 一种莫吉司坦干混悬剂及其制备方法 - Google Patents
一种莫吉司坦干混悬剂及其制备方法 Download PDFInfo
- Publication number
- CN101637441B CN101637441B CN2008101262608A CN200810126260A CN101637441B CN 101637441 B CN101637441 B CN 101637441B CN 2008101262608 A CN2008101262608 A CN 2008101262608A CN 200810126260 A CN200810126260 A CN 200810126260A CN 101637441 B CN101637441 B CN 101637441B
- Authority
- CN
- China
- Prior art keywords
- weight portion
- moguisteine
- weight
- essence
- agent
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- WSYVIAQNTFPTBI-UHFFFAOYSA-N ethyl 3-[2-[(2-methoxyphenoxy)methyl]-1,3-thiazolidin-3-yl]-3-oxopropanoate Chemical compound CCOC(=O)CC(=O)N1CCSC1COC1=CC=CC=C1OC WSYVIAQNTFPTBI-UHFFFAOYSA-N 0.000 title claims abstract description 101
- 229950009623 moguisteine Drugs 0.000 title claims abstract description 101
- 239000000725 suspension Substances 0.000 title claims abstract description 67
- 238000002360 preparation method Methods 0.000 title abstract description 20
- 239000000945 filler Substances 0.000 claims abstract description 25
- 239000000375 suspending agent Substances 0.000 claims abstract description 25
- 238000000034 method Methods 0.000 claims description 60
- 239000003795 chemical substances by application Substances 0.000 claims description 36
- 239000008187 granular material Substances 0.000 claims description 27
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 22
- 239000000080 wetting agent Substances 0.000 claims description 19
- 239000000203 mixture Substances 0.000 claims description 18
- 238000001035 drying Methods 0.000 claims description 14
- GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 claims description 12
- 229930006000 Sucrose Natural products 0.000 claims description 12
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 claims description 12
- 239000008101 lactose Substances 0.000 claims description 12
- 239000005720 sucrose Substances 0.000 claims description 12
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 12
- 238000002156 mixing Methods 0.000 claims description 11
- 239000003643 water by type Substances 0.000 claims description 11
- 235000009508 confectionery Nutrition 0.000 claims description 10
- 239000001768 carboxy methyl cellulose Substances 0.000 claims description 9
- 238000005469 granulation Methods 0.000 claims description 9
- 230000003179 granulation Effects 0.000 claims description 9
- 229920000168 Microcrystalline cellulose Polymers 0.000 claims description 8
- 239000008108 microcrystalline cellulose Substances 0.000 claims description 8
- 229940016286 microcrystalline cellulose Drugs 0.000 claims description 8
- 235000019813 microcrystalline cellulose Nutrition 0.000 claims description 8
- 229920000609 methyl cellulose Polymers 0.000 claims description 7
- 239000001923 methylcellulose Substances 0.000 claims description 7
- 239000007779 soft material Substances 0.000 claims description 7
- NIXOWILDQLNWCW-UHFFFAOYSA-N Acrylic acid Chemical compound OC(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 claims description 5
- 229920002125 Sokalan® Polymers 0.000 claims description 5
- 229960001631 carbomer Drugs 0.000 claims description 5
- 239000002245 particle Substances 0.000 claims description 5
- 229920002134 Carboxymethyl cellulose Polymers 0.000 claims description 4
- FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 claims description 4
- 229930195725 Mannitol Natural products 0.000 claims description 4
- 238000007605 air drying Methods 0.000 claims description 4
- 235000010948 carboxy methyl cellulose Nutrition 0.000 claims description 4
- 239000008112 carboxymethyl-cellulose Substances 0.000 claims description 4
- 239000000796 flavoring agent Substances 0.000 claims description 4
- 235000019634 flavors Nutrition 0.000 claims description 4
- 239000000594 mannitol Substances 0.000 claims description 4
- 235000010355 mannitol Nutrition 0.000 claims description 4
- FTLYMKDSHNWQKD-UHFFFAOYSA-N (2,4,5-trichlorophenyl)boronic acid Chemical compound OB(O)C1=CC(Cl)=C(Cl)C=C1Cl FTLYMKDSHNWQKD-UHFFFAOYSA-N 0.000 claims description 3
- 239000004375 Dextrin Substances 0.000 claims description 3
- 229920001353 Dextrin Polymers 0.000 claims description 3
- XINCECQTMHSORG-UHFFFAOYSA-N Isoamyl isovalerate Chemical compound CC(C)CCOC(=O)CC(C)C XINCECQTMHSORG-UHFFFAOYSA-N 0.000 claims description 3
- 229920000881 Modified starch Polymers 0.000 claims description 3
- UEDUENGHJMELGK-HYDKPPNVSA-N Stevioside Chemical compound O([C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1O[C@]12C(=C)C[C@@]3(C1)CC[C@@H]1[C@@](C)(CCC[C@]1([C@@H]3CC2)C)C(=O)O[C@H]1[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O1)O)[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O UEDUENGHJMELGK-HYDKPPNVSA-N 0.000 claims description 3
- 235000010489 acacia gum Nutrition 0.000 claims description 3
- 239000001785 acacia senegal l. willd gum Substances 0.000 claims description 3
- FUFJGUQYACFECW-UHFFFAOYSA-L calcium hydrogenphosphate Chemical compound [Ca+2].OP([O-])([O-])=O FUFJGUQYACFECW-UHFFFAOYSA-L 0.000 claims description 3
- 239000006071 cream Substances 0.000 claims description 3
- 235000019425 dextrin Nutrition 0.000 claims description 3
- 235000019700 dicalcium phosphate Nutrition 0.000 claims description 3
- -1 hydroxypropyl Chemical group 0.000 claims description 3
- XMGQYMWWDOXHJM-UHFFFAOYSA-N limonene Chemical compound CC(=C)C1CCC(C)=CC1 XMGQYMWWDOXHJM-UHFFFAOYSA-N 0.000 claims description 3
- 239000007968 orange flavor Substances 0.000 claims description 3
- 229920000036 polyvinylpyrrolidone Polymers 0.000 claims description 3
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 claims description 3
- 229940085605 saccharin sodium Drugs 0.000 claims description 3
- 229940013618 stevioside Drugs 0.000 claims description 3
- OHHNJQXIOPOJSC-UHFFFAOYSA-N stevioside Natural products CC1(CCCC2(C)C3(C)CCC4(CC3(CCC12C)CC4=C)OC5OC(CO)C(O)C(O)C5OC6OC(CO)C(O)C(O)C6O)C(=O)OC7OC(CO)C(O)C(O)C7O OHHNJQXIOPOJSC-UHFFFAOYSA-N 0.000 claims description 3
- 235000019202 steviosides Nutrition 0.000 claims description 3
- 239000000230 xanthan gum Substances 0.000 claims description 3
- 235000010493 xanthan gum Nutrition 0.000 claims description 3
- 229920001285 xanthan gum Polymers 0.000 claims description 3
- 229940082509 xanthan gum Drugs 0.000 claims description 3
- 206010011224 Cough Diseases 0.000 abstract description 9
- 238000010521 absorption reaction Methods 0.000 abstract description 7
- 230000008901 benefit Effects 0.000 abstract description 4
- 238000009826 distribution Methods 0.000 abstract description 2
- 235000003599 food sweetener Nutrition 0.000 abstract 1
- 239000003765 sweetening agent Substances 0.000 abstract 1
- 239000003814 drug Substances 0.000 description 34
- 239000000463 material Substances 0.000 description 20
- 239000002671 adjuvant Substances 0.000 description 11
- 229940079593 drug Drugs 0.000 description 11
- 230000008569 process Effects 0.000 description 10
- 238000010298 pulverizing process Methods 0.000 description 9
- 239000008280 blood Substances 0.000 description 7
- 210000004369 blood Anatomy 0.000 description 7
- 241000282472 Canis lupus familiaris Species 0.000 description 6
- 239000000843 powder Substances 0.000 description 6
- DPXJVFZANSGRMM-UHFFFAOYSA-N acetic acid;2,3,4,5,6-pentahydroxyhexanal;sodium Chemical compound [Na].CC(O)=O.OCC(O)C(O)C(O)C(O)C=O DPXJVFZANSGRMM-UHFFFAOYSA-N 0.000 description 5
- 238000011156 evaluation Methods 0.000 description 5
- 235000019812 sodium carboxymethyl cellulose Nutrition 0.000 description 5
- 229920001027 sodium carboxymethylcellulose Polymers 0.000 description 5
- 239000007787 solid Substances 0.000 description 5
- 239000003826 tablet Substances 0.000 description 5
- 235000019658 bitter taste Nutrition 0.000 description 4
- 238000004090 dissolution Methods 0.000 description 4
- 230000000694 effects Effects 0.000 description 4
- 238000004519 manufacturing process Methods 0.000 description 4
- 239000000126 substance Substances 0.000 description 4
- 238000005550 wet granulation Methods 0.000 description 4
- YXFVVABEGXRONW-UHFFFAOYSA-N Toluene Chemical compound CC1=CC=CC=C1 YXFVVABEGXRONW-UHFFFAOYSA-N 0.000 description 3
- 239000006185 dispersion Substances 0.000 description 3
- 238000009472 formulation Methods 0.000 description 3
- 239000001866 hydroxypropyl methyl cellulose Substances 0.000 description 3
- 229920003088 hydroxypropyl methyl cellulose Polymers 0.000 description 3
- 235000010979 hydroxypropyl methyl cellulose Nutrition 0.000 description 3
- UFVKGYZPFZQRLF-UHFFFAOYSA-N hydroxypropyl methyl cellulose Chemical compound OC1C(O)C(OC)OC(CO)C1OC1C(O)C(O)C(OC2C(C(O)C(OC3C(C(O)C(O)C(CO)O3)O)C(CO)O2)O)C(CO)O1 UFVKGYZPFZQRLF-UHFFFAOYSA-N 0.000 description 3
- 239000007788 liquid Substances 0.000 description 3
- 210000002345 respiratory system Anatomy 0.000 description 3
- 210000002784 stomach Anatomy 0.000 description 3
- 230000035882 stress Effects 0.000 description 3
- 229920002472 Starch Polymers 0.000 description 2
- 230000000954 anitussive effect Effects 0.000 description 2
- OSGAYBCDTDRGGQ-UHFFFAOYSA-L calcium sulfate Chemical compound [Ca+2].[O-]S([O-])(=O)=O OSGAYBCDTDRGGQ-UHFFFAOYSA-L 0.000 description 2
- 239000002775 capsule Substances 0.000 description 2
- 230000008859 change Effects 0.000 description 2
- 230000002496 gastric effect Effects 0.000 description 2
- 238000000227 grinding Methods 0.000 description 2
- 238000005286 illumination Methods 0.000 description 2
- 238000009776 industrial production Methods 0.000 description 2
- 229940068196 placebo Drugs 0.000 description 2
- 239000000902 placebo Substances 0.000 description 2
- 238000012545 processing Methods 0.000 description 2
- 239000000047 product Substances 0.000 description 2
- 238000011160 research Methods 0.000 description 2
- 208000023504 respiratory system disease Diseases 0.000 description 2
- 238000012216 screening Methods 0.000 description 2
- 239000007921 spray Substances 0.000 description 2
- 239000008107 starch Substances 0.000 description 2
- 235000019698 starch Nutrition 0.000 description 2
- 238000003860 storage Methods 0.000 description 2
- 235000019605 sweet taste sensations Nutrition 0.000 description 2
- 208000024891 symptom Diseases 0.000 description 2
- 238000012360 testing method Methods 0.000 description 2
- 238000012546 transfer Methods 0.000 description 2
- 239000004925 Acrylic resin Substances 0.000 description 1
- 206010067484 Adverse reaction Diseases 0.000 description 1
- GUBGYTABKSRVRQ-XLOQQCSPSA-N Alpha-Lactose Chemical compound O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)O[C@H](O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-XLOQQCSPSA-N 0.000 description 1
- 244000099147 Ananas comosus Species 0.000 description 1
- 235000007119 Ananas comosus Nutrition 0.000 description 1
- 229920002101 Chitin Polymers 0.000 description 1
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 description 1
- FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 description 1
- 208000019505 Deglutition disease Diseases 0.000 description 1
- 206010012335 Dependence Diseases 0.000 description 1
- 235000016623 Fragaria vesca Nutrition 0.000 description 1
- 240000009088 Fragaria x ananassa Species 0.000 description 1
- 235000011363 Fragaria x ananassa Nutrition 0.000 description 1
- 241000167880 Hirundinidae Species 0.000 description 1
- 229920002153 Hydroxypropyl cellulose Polymers 0.000 description 1
- 206010062717 Increased upper airway secretion Diseases 0.000 description 1
- 240000008790 Musa x paradisiaca Species 0.000 description 1
- 235000018290 Musa x paradisiaca Nutrition 0.000 description 1
- 239000002202 Polyethylene glycol Substances 0.000 description 1
- 239000004372 Polyvinyl alcohol Substances 0.000 description 1
- 235000011158 Prunus mume Nutrition 0.000 description 1
- 244000018795 Prunus mume Species 0.000 description 1
- 241000220317 Rosa Species 0.000 description 1
- 239000004376 Sucralose Substances 0.000 description 1
- TVXBFESIOXBWNM-UHFFFAOYSA-N Xylitol Natural products OCCC(O)C(O)C(O)CCO TVXBFESIOXBWNM-UHFFFAOYSA-N 0.000 description 1
- 230000002159 abnormal effect Effects 0.000 description 1
- 230000006838 adverse reaction Effects 0.000 description 1
- 230000032683 aging Effects 0.000 description 1
- 229940124584 antitussives Drugs 0.000 description 1
- 238000005452 bending Methods 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000037396 body weight Effects 0.000 description 1
- 238000009954 braiding Methods 0.000 description 1
- 125000002057 carboxymethyl group Chemical group [H]OC(=O)C([H])([H])[*] 0.000 description 1
- 210000003169 central nervous system Anatomy 0.000 description 1
- 239000007795 chemical reaction product Substances 0.000 description 1
- 239000000064 cholinergic agonist Substances 0.000 description 1
- 238000004140 cleaning Methods 0.000 description 1
- 238000007906 compression Methods 0.000 description 1
- 230000006835 compression Effects 0.000 description 1
- 238000005336 cracking Methods 0.000 description 1
- 238000007604 dielectric heating drying Methods 0.000 description 1
- ZZVUWRFHKOJYTH-UHFFFAOYSA-N diphenhydramine Chemical compound C=1C=CC=CC=1C(OCCN(C)C)C1=CC=CC=C1 ZZVUWRFHKOJYTH-UHFFFAOYSA-N 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 239000002552 dosage form Substances 0.000 description 1
- 238000007908 dry granulation Methods 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 230000007613 environmental effect Effects 0.000 description 1
- 238000003912 environmental pollution Methods 0.000 description 1
- 230000003203 everyday effect Effects 0.000 description 1
- 239000003172 expectorant agent Substances 0.000 description 1
- 230000003419 expectorant effect Effects 0.000 description 1
- 239000012530 fluid Substances 0.000 description 1
- 235000013305 food Nutrition 0.000 description 1
- 239000003205 fragrance Substances 0.000 description 1
- 230000004927 fusion Effects 0.000 description 1
- 238000010438 heat treatment Methods 0.000 description 1
- 238000000589 high-performance liquid chromatography-mass spectrometry Methods 0.000 description 1
- 239000001863 hydroxypropyl cellulose Substances 0.000 description 1
- 235000010977 hydroxypropyl cellulose Nutrition 0.000 description 1
- 208000015181 infectious disease Diseases 0.000 description 1
- 230000000977 initiatory effect Effects 0.000 description 1
- 238000011031 large-scale manufacturing process Methods 0.000 description 1
- 210000003141 lower extremity Anatomy 0.000 description 1
- 206010025482 malaise Diseases 0.000 description 1
- 230000007246 mechanism Effects 0.000 description 1
- 238000002844 melting Methods 0.000 description 1
- 230000008018 melting Effects 0.000 description 1
- HEBKCHPVOIAQTA-UHFFFAOYSA-N meso ribitol Natural products OCC(O)C(O)C(O)CO HEBKCHPVOIAQTA-UHFFFAOYSA-N 0.000 description 1
- 239000002207 metabolite Substances 0.000 description 1
- 238000003801 milling Methods 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 230000003533 narcotic effect Effects 0.000 description 1
- 229910052755 nonmetal Inorganic materials 0.000 description 1
- 239000007935 oral tablet Substances 0.000 description 1
- 229940096978 oral tablet Drugs 0.000 description 1
- 238000012856 packing Methods 0.000 description 1
- 208000026435 phlegm Diseases 0.000 description 1
- 229940023488 pill Drugs 0.000 description 1
- 239000006187 pill Substances 0.000 description 1
- 229920001223 polyethylene glycol Polymers 0.000 description 1
- 229920000642 polymer Polymers 0.000 description 1
- 229920002451 polyvinyl alcohol Polymers 0.000 description 1
- 239000002994 raw material Substances 0.000 description 1
- 239000013558 reference substance Substances 0.000 description 1
- 238000010008 shearing Methods 0.000 description 1
- 238000007086 side reaction Methods 0.000 description 1
- 239000007901 soft capsule Substances 0.000 description 1
- 239000000600 sorbitol Substances 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
- 235000019408 sucralose Nutrition 0.000 description 1
- BAQAVOSOZGMPRM-QBMZZYIRSA-N sucralose Chemical compound O[C@@H]1[C@@H](O)[C@@H](Cl)[C@@H](CO)O[C@@H]1O[C@@]1(CCl)[C@@H](O)[C@H](O)[C@@H](CCl)O1 BAQAVOSOZGMPRM-QBMZZYIRSA-N 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
- 239000000811 xylitol Substances 0.000 description 1
- 235000010447 xylitol Nutrition 0.000 description 1
- HEBKCHPVOIAQTA-SCDXWVJYSA-N xylitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)CO HEBKCHPVOIAQTA-SCDXWVJYSA-N 0.000 description 1
- 229960002675 xylitol Drugs 0.000 description 1
Images
Landscapes
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicinal Preparation (AREA)
Abstract
Description
原料(mg) | 实施例1 | 实施例2 | 实施例3 | 实施例4 | 实施例5 | 实施例6 | 实施例7 |
莫吉司坦 | 100 | 100 | 100 | 100 | 100 | 100 | 100 |
乳糖 | 100 | 200 | 150 | 200 | 150 | 100 | 150 |
微晶纤维素 | 50 | / | 100 | / | / | 50 | / |
羧甲基纤维素 | 100 | 100 | / | / | / | 50 | 50 |
羟丙甲基纤维素 | / | / | 50 | / | / | 20 | / |
甲基纤维素 | / | / | / | 60 | 50 | / | 30 |
卡波姆 | / | / | / | / | 20 | / | / |
蔗糖 | 50 | 30 | 50 | 30 | 50 | 50 | 50 |
桔子香精 | 5 | 5 | 10 | 5 | 5 | 10 | 5 |
口感评价 | 一般 | 甜 | 香甜 | 一般 | 一般 | 香甜 | 甜 |
沉降体积比 | 0.98 | 0.95 | 0.92 | 0.97 | 0.94 | 0.95 | 0.92 |
环境条件/时间 | 性状 | 沉降体积比 | 吸湿增重(%) | 有关物质含量(%) | 莫吉司坦含量(重量%) | 溶出度(%) |
-/0天 | 类白色颗粒 | 0.96 | / | 0.67 | 98.23 | 90.1 |
高温(40℃)/10天 | 类白色颗粒 | 0.97 | -0.12 | 0.82 | 98.89 | 91.4 |
高湿(75%±5%)/10天 | 类白色颗粒 | 0.94 | 9.54 | 0.76 | 98.45 | 89.7 |
光照(4500±500勒克斯)/10天 | 类白色颗粒 | 0.96 | 0.42 | 0.71 | 98.71 | 88.7 |
Claims (10)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN2008101262608A CN101637441B (zh) | 2008-07-28 | 2008-07-28 | 一种莫吉司坦干混悬剂及其制备方法 |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN2008101262608A CN101637441B (zh) | 2008-07-28 | 2008-07-28 | 一种莫吉司坦干混悬剂及其制备方法 |
Publications (2)
Publication Number | Publication Date |
---|---|
CN101637441A CN101637441A (zh) | 2010-02-03 |
CN101637441B true CN101637441B (zh) | 2011-11-23 |
Family
ID=41612743
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN2008101262608A Expired - Fee Related CN101637441B (zh) | 2008-07-28 | 2008-07-28 | 一种莫吉司坦干混悬剂及其制备方法 |
Country Status (1)
Country | Link |
---|---|
CN (1) | CN101637441B (zh) |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN102697779B (zh) * | 2012-06-01 | 2014-11-05 | 康阳润和(北京)医药科技有限公司 | 高溶散速率的伊来西胺药物组合物及其制法 |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1559424A (zh) * | 2004-03-03 | 2005-01-05 | 复旦大学 | 灯盏花素干混悬剂 |
CN1631371A (zh) * | 2004-12-20 | 2005-06-29 | 李�杰 | 口服无苦味的大环内酯类抗生素散剂及其处方和制备方法 |
CN101129358A (zh) * | 2007-07-11 | 2008-02-27 | 山东省医药工业研究所 | 莫吉司坦缓释片及其制备方法 |
-
2008
- 2008-07-28 CN CN2008101262608A patent/CN101637441B/zh not_active Expired - Fee Related
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1559424A (zh) * | 2004-03-03 | 2005-01-05 | 复旦大学 | 灯盏花素干混悬剂 |
CN1631371A (zh) * | 2004-12-20 | 2005-06-29 | 李�杰 | 口服无苦味的大环内酯类抗生素散剂及其处方和制备方法 |
CN101129358A (zh) * | 2007-07-11 | 2008-02-27 | 山东省医药工业研究所 | 莫吉司坦缓释片及其制备方法 |
Also Published As
Publication number | Publication date |
---|---|
CN101637441A (zh) | 2010-02-03 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CN107666914A (zh) | 帕博西尼的固体剂型 | |
CN104546747A (zh) | 一种含有甲磺酸沙芬酰胺的药物组合物及其制备方法 | |
CN112585192B (zh) | 纤维素粉末、其用途及片剂 | |
CN1785340A (zh) | 一种复方牛黄清胃快速分散固体制剂及其制备方法 | |
CN101637461A (zh) | 一种莫吉司坦分散片及其制备方法 | |
CN101637441B (zh) | 一种莫吉司坦干混悬剂及其制备方法 | |
CN1785336A (zh) | 一种通幽润燥快速分散固体制剂及其制备方法 | |
CN111803452A (zh) | 一种包含盐酸去氧肾上腺素组合物的泡腾颗粒剂制备工艺 | |
CN101401796A (zh) | 普拉克索口腔崩解片及其制备方法 | |
CN101284011A (zh) | 一种齐墩果酸口腔崩解片及其制备方法 | |
CN1329062C (zh) | 一种治疗骨折及软组织损伤药物的制备方法 | |
AU2013347264B2 (en) | Dispersible tablet | |
CN100364502C (zh) | 知柏地黄快速分散固体制剂及其制备方法 | |
US8741344B1 (en) | Dispersible tablet | |
CN100515399C (zh) | 一种左金快速分散固体制剂及其制备方法 | |
WO2013177833A1 (zh) | 一种治疗痛经的药物及其制备方法 | |
CN101564515A (zh) | 一种骨刺制剂及其制备方法 | |
CN102247331B (zh) | 一种头孢羟氨苄咀嚼片及其制备方法 | |
CN101496818B (zh) | 肾骨咀嚼片及其制备方法 | |
CN101120928A (zh) | 一种维生素k1口腔崩解片制剂及其制备方法 | |
CN1785259A (zh) | 一种金锁固精快速分散固体制剂及其制备方法 | |
CN1785290A (zh) | 一种壮腰健肾快速分散固体制剂及其制备方法 | |
CN104257611B (zh) | 一种含微粉化盐酸非索非那定的药物组合物 | |
US20150283083A1 (en) | Dispersible Tablet | |
CN111450163B (zh) | 一种黄连药物组合物及应用 |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
C06 | Publication | ||
PB01 | Publication | ||
C10 | Entry into substantive examination | ||
SE01 | Entry into force of request for substantive examination | ||
ASS | Succession or assignment of patent right |
Owner name: FOSHAN DAYI SCIENCE AND TECHNOLOGY CO., LTD. Free format text: FORMER OWNER: DONGGUAN TAILI BIOTECHNOLOGY CO., LTD. Effective date: 20100402 |
|
C41 | Transfer of patent application or patent right or utility model | ||
COR | Change of bibliographic data |
Free format text: CORRECT: ADDRESS; FROM: 523581 GAOBAO GREEN SCIENCE CITY,TUTANG INDUSTRIAL ZONE, CHANGPING TOWN, DONGGUAN CITY, GUANGDONG PROVINCE TO: 510665 NO.19, XIANGSHAN ROAD, SCIENCE CITY, HIGH-TECH DEVELOPMENT ZONE, GUANGZHOU CITY, GUANGDONG PROVINCE |
|
TA01 | Transfer of patent application right |
Effective date of registration: 20100402 Address after: 510665 No. 19 incense Hill Road, science and Technology Town, Guangzhou hi tech Development Zone, Guangdong, China Applicant after: Foshan Dayi Technology Co., Ltd. Address before: 523581 KBA green science and Technology City, Changping Town, Dongguan City, Guangdong Province Applicant before: Dongguan Taili Biotech Co., Ltd. |
|
ASS | Succession or assignment of patent right |
Owner name: GUANGZHOU DAXIN BIOTECHNOLOGY CO., LTD. Free format text: FORMER OWNER: FOSHAN DAYI TECHNOLOGY CO., LTD. Effective date: 20110413 |
|
C41 | Transfer of patent application or patent right or utility model | ||
TA01 | Transfer of patent application right |
Effective date of registration: 20110413 Address after: 510665 No. 19 incense Hill Road, science and Technology Town, Guangzhou hi tech Development Zone, Guangdong, China Applicant after: Dongying Taili Biological Engineer Co., Ltd. Address before: 510665 No. 19 incense Hill Road, science and Technology Town, Guangzhou hi tech Development Zone, Guangdong, China Applicant before: Foshan Dayi Technology Co., Ltd. |
|
C14 | Grant of patent or utility model | ||
GR01 | Patent grant | ||
CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20111123 Termination date: 20180728 |
|
CF01 | Termination of patent right due to non-payment of annual fee |