CN101628056A

CN101628056A - Compound composition for relaxing bowels and lowering sugar

Info

Publication number: CN101628056A
Application number: CN200910017381A
Authority: CN
Inventors: 刘志美; 詹霞; 于卫红
Original assignee: Individual
Current assignee: Individual
Priority date: 2009-08-05
Filing date: 2009-08-05
Publication date: 2010-01-20
Anticipated expiration: 2029-08-05
Also published as: CN101628056B

Abstract

The invention relates to the field of the formula of the medicine, in particular to a compound composition for relaxing bowels and lowering sugar. The preparation method comprises the following steps: adopting astragalus root, rehmannia root, figwort, angelica, poncirus trifoliata, tuber fleeceflower, peach kernel, semen trichosanthis and rhubarb as raw materials, soaking with water, then decocting and deslagging to obtain filtrate. The compound composition is technically characterized by comprising the following raw materials by weight percent: 12-23% of astragalus root, 12-22% of rehmannia root, 8-10% of figwort, 12-16% of angelica, 4-6% of poncirus trifoliata, 10-14% of tuber fleeceflower, 10-12% of peach kernel, 8-10% of semen trichosanthis and 2-3% of rhubarb. The invention has definite curative effect, low cost and no toxic or side effect and is used for treating diabetes class constipation.

Description

Compound composition for relaxing bowels and lowering sugar

Technical field

The present invention relates to a kind of Chinese patent medicine preparation, specifically a kind of compound composition for relaxing bowels and lowering sugar that is used for the treatment of diabetic constipation.

Background technology

As everyone knows, along with people living condition's improvement, the change of life style, the sickness rate of diabetes and complication raises day by day, the diabetic gastrointestinal disease is the common chronic complicating diseases of diabetes, prevalence is 30%-76%, and the constipation common sympton that is the diabetes gastrointestinal disease accounts for 60%, its pathogenesis still imperfectly understands, may be because hyperglycemia effect and Developmental and Metabolic Disorder cause neural malnutrition, domination gastrointestinal nerve damage.

Western medicine does not still have the specific treatment ways and means at present, symptomatic treatment medicine commonly used: cisapride sheet, phenolphthalein tablets etc., but part patient has dizziness, distending pain in the head, drowsiness, reactions such as tongue is numb, abdominal discomfort, arrhythmia, can not tolerate, the case report that gynecomasty, galactorrhea, convulsibility epilepsy, The extrapyramidal symptoms and frequent micturition were once arranged, limited its clinical practice, the people's health in serious threat, and quality of life is descended comprehensively.

Summary of the invention

Purpose of the present invention is exactly in order to overcome above-mentioned existing technical deficiency, and a kind of determined curative effect is provided, and is with low cost, the compound composition for relaxing bowels and lowering sugar that has no side effect.

The technical scheme that the present invention solves the problems of the technologies described above employing is: a kind of compound composition for relaxing bowels and lowering sugar, and adopting the Radix Astragali, the Radix Rehmanniae, Radix Scrophulariae, Radix Angelicae Sinensis, Fructus Aurantii, Radix Polygoni Multiflori, Semen Persicae, Semen Trichosanthis, Radix Et Rhizoma Rhei is raw material, is soaked in water, remove slag after decocting filtrate, its technical characterictic is, raw material is formed and is by weight percentage: the Radix Astragali 12～23, the Radix Rehmanniae 12～22, Radix Scrophulariae 8～10, Radix Angelicae Sinensis 12～16, Fructus Aurantii 4～6%, Radix Polygoni Multiflori 10～14, Semen Persicae 10～12, Semen Trichosanthis 8～10, Radix Et Rhizoma Rhei 2～3.

The invention has the beneficial effects as follows, determined curative effect, with low cost, have no side effect.

The specific embodiment

The invention will be further described below in conjunction with embodiment:

Embodiment 1:

Adopting the Radix Astragali, the Radix Rehmanniae, Radix Scrophulariae, Radix Angelicae Sinensis, Fructus Aurantii, Radix Polygoni Multiflori, Semen Persicae, Semen Trichosanthis, Radix Et Rhizoma Rhei is that feedstock production forms, and its component (weight %) is the Radix Astragali 20, the Radix Rehmanniae 16, Radix Scrophulariae 10, Radix Angelicae Sinensis 14, Fructus Aurantii 6, Radix Polygoni Multiflori 10, Semen Persicae 11, Semen Trichosanthis 10, Radix Et Rhizoma Rhei 3 is got 58 kilograms of above-mentioned nine kinds of raw material gross weights, after selected the cleaning, with 20000ml water logging bubble 3-4 hour, decoct 60 minutes then at ambient temperature, through the routine filtration of removing slag, high pressure, behind the sterilization process, gained filtrate 9000ml, sterile bag packing, sealing, every bag of 150ml.Early, late twice (medicine) being taken before meal, each oral one bag, 10 days is a course of treatment, each course of treatment is every three days, takes three courses of treatment of mixture of the present invention continuously.

Therapeutic Principle of the present invention: diabetic constipation belongs to quench one's thirst constipation category in the deteriorated case of the traditional Chinese medical science, and the scorching blood stasis of deficiency of qi and yin is important pathogenesis, runs through primary disease all the time.Diabetic constipation be the course of disease with the passing of time, the scorching blood stasis of deficiency of qi and yin more very, cloudy body fluid deficiency void, large intestine not flourish and conduct unable due to, its pathogenesis is the cloudy body fluid deficiency of gas, the dryness of the intestine blood stasis, so treat with supplementing QI and nourishing YIN, moisturize purge heat, blood circulation promoting and blood stasis dispelling is rule.In the component of the present invention: Radix Astragali invigorating the spleen and benefiting QI, Radix Rehmanniae nourishing YIN and clearing away heat, promote the production of body fluid, the two is a monarch drug, supplementing QI and nourishing YIN promotes the production of body fluid, intestine moistening dry with relieving constipation, the pathogenesis that hits and quench one's thirst, modern pharmacological research shows that the Radix Astragali has dual regulation to blood glucose, the diabetic plasma insulin of promotion and the excretory effect of C peptide are arranged, and the Radix Rehmanniae can obviously reduce the hyperglycemia level, increases hepatic glycogen content.Radix Scrophulariae, Radix Angelicae Sinensis, Radix Polygoni Multiflori are ministerial drug, share the yin nourishing of enriching blood, promote the production of body fluid that to moisturize be supplementing fluid to relax the bowels, with loosening bowel to relieve constipation." Required Readings for Medical Professionals ": " method is worked as invigorating QI and blood, and body fluid is given birth to then from logical justice." the modern pharmacological research Radix Scrophulariae has slight blood sugar lowering, promotes the local blood circulation effect that Radix Angelicae Sinensis, Radix Polygoni Multiflori can promote enterokinesia and slight discharge function is arranged.The Fructus Aurantii conducting blood to flow downwards, Semen Persicae disperse blood stasis and dredge collateral, loosening bowel to relieve constipation, Semen Trichosanthis relieving stuffiness in the epigastrium eliminating stagnation, loosening bowel to relieve constipation is adjuvant drug altogether, and pharmacological research shows that Semen Persicae is rich in fatty oil Castor Oil intestinal, is beneficial to defecation, and Semen Trichosanthis has the laxation effect down of rushing down.Get Radix Et Rhizoma Rhei detoxifcation the turbid descending less.Purge heat, relieving constipation, be messenger drug, Radix Et Rhizoma Rhei rushes down down that effective ingredient is the anthracene glycoside, mainly is the Senna fruit glycoside, site of action can increase enterokinesia and suppress the enteral moisture absorption mainly at large intestine, promotes defecation.All medicines share profit and do not grow greasy, cool and impairment of YIN not, supplementing QI and nourishing YIN, the blood stasis dispelling intestine moistening makes three warmers fluent, constipation is dredged and is separated.The present invention has the adjusting gastrointestinal function, promotes enterokinesia, constipation relieving symptom, but auxiliary adjustment blood glucose effect simultaneously, and clinical practice treatment diabetic constipation is obtained good efficacy.

Embodiment 2:

Adopting the Radix Astragali, the Radix Rehmanniae, Radix Scrophulariae, Radix Angelicae Sinensis, Fructus Aurantii, Radix Polygoni Multiflori, Semen Persicae, Semen Trichosanthis, Radix Et Rhizoma Rhei is that feedstock production forms, and its component (weight %) is the Radix Astragali 18, the Radix Rehmanniae 18, Radix Scrophulariae 10, Radix Angelicae Sinensis 13, Fructus Aurantii 6, Radix Polygoni Multiflori 11, Semen Persicae 12, Semen Trichosanthis 9, Radix Et Rhizoma Rhei 3 is got 58 kilograms of above-mentioned nine kinds of raw material gross weights, after selected the cleaning, with 20000ml water logging bubble 3-4 hour, decoct 60 minutes then at ambient temperature, through the routine filtration of removing slag, high pressure, behind the sterilization process, gained filtrate 9000ml, sterile bag packing, sealing, every bag of 150ml.Early, late twice (medicine) being taken before meal, each oral one bag, 10 days is a course of treatment, each course of treatment is every three days, takes three courses of treatment of mixture of the present invention continuously.

But each raw material of the present invention also blended embodiment of the listed ratio of according to the form below (percentage by weight) is realized.Its processing technique is identical with embodiment 1.

Embodiment	The Radix Astragali	The Radix Rehmanniae	Radix Scrophulariae	Radix Angelicae Sinensis	Fructus Aurantii	Radix Polygoni Multiflori	Semen Persicae	Semen Trichosanthis	Radix Et Rhizoma Rhei
Embodiment	The Radix Astragali	The Radix Rehmanniae	Radix Scrophulariae	Radix Angelicae Sinensis	Fructus Aurantii	Radix Polygoni Multiflori	Semen Persicae	Semen Trichosanthis	Radix Et Rhizoma Rhei	??3	??12	??22	??8	??16	??4	??14	??11	??10	??3
??4	??23	??15	??10	??12	??6	??10	??12	??10	??2	??3	??12	??22	??8	??16	??4	??14	??11	??10	??3
??4	??23	??15	??10	??12	??6	??10	??12	??10	??2	??5	??23	??12	??9	??15	??6	??14	??10	??8	??3
??6	??17	??20	??9	??14	??5	??12	??12	??9	??2	??5	??23	??12	??9	??15	??6	??14	??10	??8	??3

Below in conjunction with my institute, promptly the clinical preliminary test that carries out of Shandong Province Wendeng Central Hospital, Weihai City is done further, is described in detail the present invention:

1, case is selected: this organizes 60 examples, male 32 examples, women 28 examples, age 21-64 year, 40 years old mean age, course of disease 2-27, average 10.2 years.

2, Therapeutic Method: early, late twice (medicine) being taken before meal, each oral one bag, 10 days is a course of treatment, and continuously took the present invention three courses of treatment every three days each course of treatment.

3, diagnostic criteria: observe the diagnostic criteria that case diabetes diagnosis standard all meets WHO proposition in 1997, and there is defecation in various degree to require great effort, constipation with dry stool, clinical manifestations such as defecation frequency minimizing, get rid of the serious heart, brain, kidney complication, colon, rectum organic disease are got rid of in the barium enema of x line, and Metcalf improves and simplifies technical measurement colon transhipment time (CTT) all above upper limits of normal 56 hours.

4, criterion of therapeutical effect: formulate with reference to relevant criterion in " traditional Chinese medical science disease diagnosis criterion of therapeutical effect " and " the new Chinese medicine clinical research guideline (trying) ".Cure: in two days defecation once, just matter is changeed profit, unobstructed when separating just, short-term does not have recurrence.Effectively: in three days defecation once, just matter is changeed profit, separates and just owes smooth.Do not heal: symptom do not have obvious improvement or during treating the recurrence in addition increase the weight of.

5, therapeutic outcome: the present invention treats 60 examples, takes medicine three courses of treatment, cures 14 examples, effective 42 examples, invalid 4 examples, cure rate 23%, effective percentage 70%, inefficiency 7%, total effective rate 93%.

Claims

1, a kind of compound composition for relaxing bowels and lowering sugar, adopting the Radix Astragali, the Radix Rehmanniae, Radix Scrophulariae, Radix Angelicae Sinensis, Fructus Aurantii, Radix Polygoni Multiflori, Semen Persicae, Semen Trichosanthis, Radix Et Rhizoma Rhei is raw material, is soaked in water, remove slag after decocting filtrate, its technical characterictic is, raw material is formed and is by weight percentage: the Radix Astragali 12～23, the Radix Rehmanniae 12～22, Radix Scrophulariae 8～10, Radix Angelicae Sinensis 12～16, Fructus Aurantii 4～6%, Radix Polygoni Multiflori 10～14, Semen Persicae 10～12, Semen Trichosanthis 8～10, Radix Et Rhizoma Rhei 2～3.