CN101623388B - Active part of traditional Chinese medicine composite for curing diabetes and preparation method thereof - Google Patents
Active part of traditional Chinese medicine composite for curing diabetes and preparation method thereof Download PDFInfo
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- CN101623388B CN101623388B CN2009101832856A CN200910183285A CN101623388B CN 101623388 B CN101623388 B CN 101623388B CN 2009101832856 A CN2009101832856 A CN 2009101832856A CN 200910183285 A CN200910183285 A CN 200910183285A CN 101623388 B CN101623388 B CN 101623388B
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Abstract
The invention relates to an active part of a traditional Chinese medicine composite for curing diabetes. The active part is prepared from root-bark of Chinese wolfberry, ramulus euonymi, coptis chinensis and dogwood according to weight proportion. A preparation method of the actively part comprises the following steps: weighing all the medicinal materials of a prescription; decocting the medicinal materials with water with an amount which is 5 times of that of the medicinal materials; filtering; remaining filtrate; adding water with an amount which is 5 times of that of decoction dregs into the decoction dregs; decocting; filtering; combining filtrates obtained from the two times of decocting; depressurize and concentrating the combined filtrate; applying concentrated liquid on a macroporous resin column for purpose of enrichment; eluting by using ethanol with a certain concentration; collecting eluent; depressurizing and recovering solvent; concentrating the solvent to a density of 3 g of crude drug per milliliter; and obtaining the active part of the traditional Chinese medicine composite for curing diabetes. In the invention, a theory of traditional Chinese medical science is followed, namely three heats (i.e. dryness-heat, moist heat and stagnant heat) are symptoms and deficiency of qi and yin as well as hepatic and renal deficiency is as root cause, wherein the symptoms and the root causes interact as both causes and effects. The active part of the traditional Chinese medicine composite for curing diabetes on a basis of a three-heat theory is obtained. As being demonstrated by pharmacologic tests, the active part in small dosage can obviously reduce blood sugar content of a model mouse, and can achieve extremely obvious reduction of the blood sugar content of the model mouse in medium/high dosage.
Description
One, technical field:
The present invention relates to technical field of Chinese medicines, specifically relate to a kind of Chinese medicine compound effective site for the treatment of diabetes and preparation method thereof.
Two, background technology
Along with the aging of world population, diabetes have become a kind of commonly encountered diseases, frequently-occurring disease.The whole world has 1.2 hundred million diabeticss approximately, and 80% is non-insulin-dependent diabetes mellitus (2 type), and wherein China has 2,000 ten thousand.Because the death toll that diabetic complication causes has been to be listed as the 3rd after cardiovascular and cerebrovascular disease, cancer in developed country, caused countries in the world great attention (the herbal treatment progress of Li Zhi person of outstanding talent diabetes. Hangzhou Normal College's journal (medicine), 2007,27 (1): 58).
The maximum characteristics of diabetes are long and complicated, the difficult radical cures of the course of disease.Its pathophysiological change is the absolute or relative deficiency of insulin secretion, causes vitamin, water, the metabolic disturbance of electrolyte of sugar, fat, protein and secondary.Show as blood glucose, glucose in urine rising.Symptoms such as polyphagia, polydipsia, polyuria, xerostomia and general weakness appear in the patient, and the traditional Chinese medical science is referred to as to quench one's thirst.Because etiology and pathology is not illustrated as yet, still there is not the radical cure medicine at present.Type 1 diabetes is that insulin secretion is definitely not enough, can only treat with insulin substitution.And from the present hypoglycemic medicine of clinical applied treatment type 2 diabetes mellitus, various Western medicine all have certain limitation and untoward reaction, or even serious adverse effects very, as cause hypoglycemia, lactic acidosis etc.The treatment diabetes are the focuses of clinic study and new drug development always, in view of western medicine often brings bigger toxicity to the patient when obtaining curative effect.And aspect the diabetic complication treatment, Western medicine does not also have advantage.Up to the present, according to the Chinese medicine compound of theory of Chinese medical science compatibility, in treatment diabetes and complication thereof, clinical efficacy is definite, because high cost performance, more convenient application method is so be easier to be accepted by the patient.Demonstrated certain advantage, have bright development prospect (Zhu Yun is etc., blood sugar lowering medicinal plants general introduction [J]. combination of Chinese and Western medicine journal, 2004,2 (1): 67).
Three, summary of the invention
Limitation present situation at diabetes high incidence and western medicine and medical practitioners treatment the object of the present invention is to provide a kind of Chinese medicine compound effective site for the treatment of diabetes and preparation method thereof.
The objective of the invention is to realize by following technical scheme:
1. write out a prescription: a kind of Chinese medicine compound effective site for the treatment of diabetes is characterized in that it is made by following materials of weight proportions medicine:
Cortex Lycii 20-30g, Rhizoma Coptidis 5-9g, Ramulus Euonymi 20-30g, Fructus Corni 12-18g.
1.1 prescription source
This compound recipe derives from distinguished veteran doctors of TCM Mr.'s Zhou Zhongying clinical experience side.Professor Zhou Zhongying is the Chinese famous traditional Chinese medical science, traditional Chinese medical science great master, and the doctoral advisor, the government subsidies expert, year surplus industry has cured 60, be an ethical doctor, highly skilled, cure its number of the difficult meter of anxious difficult miscellaneous diseases patient.
In recent years, along with social development, the change of people's lives mode, diabetes increase year by year.This course of disease is long, the state of an illness is complicated, and complication is many, is difficult to radical cure, so so and the prescription on individual diagnosis person that comes is numerous.Zhou, teacher based oneself upon Traditional Chinese medical theory, controlled principle according to dialectical executing, and had founded understanding and the treatment original to primary disease, proposed the theory of Chinese medical science that " three heat opinions " controls diabetes.Though diabetes mostly are primary symptom with three, Zhou teacher often find symptom more than three or existence simultaneously, or the companion sees other symptom again in secular clinical practice.Zhou teacher thinks that the Traditional Chinese medical theory conclusion goes out " deficiency of YIN is scorching " and can not reflect pathogenesis comprehensively, often has more existing symptom according to diabetics, as parched throat, and xerostomia, the desire drink is for scorching; Bitter taste, sticky in mouthful, constipation with dry stool or rare half congealed, the urine amount is many, and urine mixes, and the yellowish fur difficultyization is for damp and hot; Involved and abstruse being difficult to walk of companion's urine, numb limbs and tense tendons, or easily living skin infection is to be stagnant heat; Two dryness and uneasy feeling of the eye, blurred vision, tinnitus, soreness of waist and knee, the whole body is weak, be easy to fatigue and be for deficiency of both QI and YIN, deficiency of the liver and kindey.Thereby judge: the pathology of Diabetes Mellitus factor is being designated as scorchingly, and damp and hot and stagnant heat three heat are knot mutually, is being deficiency of both QI and YIN, deficiency of the liver and kindey at this.The pathological changes internal organs are lung, taste and Liver and kidney.Thereby propose to control the viewpoint of diabetes with " three heat " opinion.
Study carefully the onset diabetes reason, though fuzzy, this patient has family history more, or long-term preference for fat and sweet food, pungent product, and long-term psychentonia, overworked or feel depressed is arranged.The overeating greasy food bringing about internal heat, the over-eating the food with sweet flavor bringing about abdominal distension, eating and drinking without temperance, preference for fat and sweet food is pungent, can cause the transporting and transforming function of the spleen and stomach dereliction of duty, long-pending humidogene heat, retention of damp-heat in the interior, dryness-transformation consumption Tianjin.It is depressed to be worried, depression of liver-QI, strongly fragrant and fire-transformation, characteristic of fire being flaring up, on burn in lung production of dryness-heat in the interior, consumption of body fluid due to lungdryness.Innate deficiency, plain body is cloudy to be lost, or labor desires excessively, and darkness of Liver and kidney consumption all can cause interior-heat caused by deficiency of YIN, and the asthenic fire blood network of burning is living in the stagnant heat.Scorching, damp and hot, stagnant heat three heat are knot mutually, the cloudy Tianjin of burning.Tianjin void can not activating QI, can cause impairment of both QI and YIN again.Therefore, three heat are mark, deficiency of both QI and YIN, and the hepatic and renal YIN deficiency is this, the two reciprocal causation.Dryness-heat impairing the lung, lung loses and makes moist, and body fluid cannot flow upwards is so xerostomia occurs, parched throat, desire drink; Damp and hot accumulateing in taste, the fortuneization function is lost strong, thus bitter taste appears, sticky in mouthful, constipation with dry stool or rare half congealed, yellow and greasy fur difficultyization; Deficiency of kidney-YIN, the deficiency of YIN and sun, the yang deficiency QI failing to transform into body fluid, kidney loses astringency inducing, or functioning of bladder haves no right, and then the urine amount is many, or urinates muddy; Stagnant heat resistance network, meridians are unfavorable, thus numb limbs and tense tendons, or easily give birth to skin infection.Deficiency of both QI and YIN, then the whole body is weak, is easy to fatigue; Caused by liver and kidney deficiency, the marrow deficiency can not flourish be supported the key network, two dryness and uneasy feeling of the eye then, blurred vision, tinnitus.
Be mark according to three heat, deficiency of both QI and YIN, caused by liver and kidney deficiency are this theory, and Zhou teacher establishes clearing away dryness and expels the heat-evil, clear sharp virtueization, cooling blood and removing stasis and supplementing QI and nourishing YIN, the rule of treatment of nourishing liver and kidney.Pay attention to adjusting lung, taste, the function of Liver and kidney.We select the prescription research of about 2,000 sufferers, according to preceding four medicines of medication frequency, and form the basis side that three heat opinions are treated diabetes and complication: Cortex Lycii 20-30g, Rhizoma Coptidis 5-9g, Ramulus Euonymi 20-30g, Fructus Corni 12-18g.Respectively at the traditional Chinese medical science the quench one's thirst pathogenesis and the important pathological factor of (diabetes), promptly remove scorchingly with Cortex Lycii, with the Rhizoma Coptidis eliminating damp-heat,,, reach the purpose for the treatment of both the principal and secondary aspects of a disease with the Fructus Corni enriching yin boost qi with Ramulus Euonymi Qinghua stagnant heat.
2. the preparation of prescription drugs effective site:
A kind of preparation method for the treatment of the Chinese medicine compound effective site of diabetes is characterized in that preparation process is as follows:
(1) takes by weighing Cortex Lycii 20-30g, Rhizoma Coptidis 5-9g, Ramulus Euonymi 20-30g, Fructus Corni 12-18g.5 times of water gagings that add the medical material amount decoct and extract 1h, filter, and filtrate is continued to employ, and medicinal residues add 5 times of water gagings again, decoct to extract 1h again, filter, and merge filtrate twice, carry out concentrating under reduced pressure;
(2) with macroporous resin column enrichment on the above-mentioned concentrated solution, with the alcoholic solution eluting of 50-70%, collect eluent, decompression and solvent recovery is concentrated into the Chinese medicine compound effective site that 3g crude drug/ml must treat diabetes.
3. pharmacodynamics test
3.1 the preparation of prescription drugs effective site
Get the prescription medical material and add 5 times of water gagings, decoct and extract 1h, filter, medicinal residues add 5 times of water gagings again, decoct to extract 1h, filter, merge filtrate twice, concentrating under reduced pressure, macroporous resin column enrichment on the concentrated solution, with the ethanol elution of 50-70%, collect eluent, decompression and solvent recovery is concentrated into 3g crude drug/ml.
3.2 blood sugar lowering experiment to animal
Choose cleaning level male mice, body weight (20 ± 2g).Allow mice adapt to a week earlier.Random packet (normal group, modeling group); Fasting is weighed after can't help water 12h, and tail vein injection 1% alloxan is given sugar-salt-water behind the 24h, in case mouse blood sugar reduces suddenly mortality rate is raise.Behind the 72h (fasting 12h), the tail point is got the hematometry fasting glucose, and blood glucose value 〉=11.1mmol/L person includes experiment in; Be equally divided into 5 groups according to blood sugar level, wherein one group is model control group, and all the other are the administration group, i.e. positive controls (glibenclamide 50mg/kg.d
-1), compound effective component high dose group (30g/kg.d
-1) middle dosage group (20g/kg.d
-1), low dose group (10g/kg.d
-1).Below respectively organize and carry out gastric infusion every day one time.Successive administration 5 days, fasting 12h before the last administration, 1h tail point is got blood and is surveyed blood glucose value after the last administration.Experimental data adopts t check carrying out statistical analysis, with
Expression the results are shown in Table 1.
Table 1 " three heat opinions " Chinese medicine compound effective site causes the influence of blood glucose in diabetic mice to alloxan
Annotate: compare *: p＜0.05, material: p＜0.01 with model control group
Beneficial effect:
The invention provides a kind of Chinese medicine compound effective site for the treatment of diabetes.Medicine is formed: Cortex Lycii 20-30g, Rhizoma Coptidis 5-9g, Ramulus Euonymi 20-30g, Fructus Corni 12-18g.Chinese medicine compound effective site of the present invention is to be mark according to " three heat ", and deficiency of both QI and YIN, caused by liver and kidney deficiency are this theory, and " three heat opinions " the treatment diabetes that propose through proved recipe, in the side Cortex Lycii remove scorching, with the Rhizoma Coptidis eliminating damp-heat, with Ramulus Euonymi Qinghua stagnant heat, with the Fructus Corni enriching yin boost qi.Be somebody's turn to do " three heat opinions " Chinese medicine compound effective site through the The pharmacological results demonstration, low dose group can significantly reduce the blood glucose value of model mice, and middle and high dosage group can extremely significantly reduce the blood glucose value (the results are shown in Table shown in 1) of model mice.
Four. the specific embodiment
Embodiment 1:
(1) prescription: Cortex Lycii 20g, Ramulus Euonymi 20g, Rhizoma Coptidis 6g, Fructus Corni 12g.
(2) preparation of prescription drugs effective site: get prescription drugs and add 5 times of water gagings, decoct and extract 1h, filter, filtrate is continued to employ, and medicinal residues add 5 times of water gagings again, decoct to extract 1h, filter, and merge filtrate twice, concentrating under reduced pressure; The 50%-70% ethanol elution is used in macroporous resin column enrichment on the concentrated solution, collects eluent, and decompression and solvent recovery is concentrated into the effective site that 3g crude drug/ml must treat the Chinese medicine compound of diabetes.
Embodiment 2:
(1) prescription: Cortex Lycii 30g, Ramulus Euonymi 30g, Rhizoma Coptidis 9g, Fructus Corni 18g.
(2) preparation of prescription drugs effective site: get prescription drugs and add 5 times of water gagings, decoct and extract 1h, filter, filtrate is continued to employ, and medicinal residues add 5 times of water gagings again, decoct to extract 1h, filter, and merge filtrate twice, concentrating under reduced pressure; The 50%-70% ethanol elution is used in macroporous resin column enrichment on the concentrated solution, collects eluent, and decompression and solvent recovery is concentrated into the effective site that 3g crude drug/ml must treat the Chinese medicine compound of diabetes.
Claims (3)
1. Chinese medicine compound effective site for the treatment of diabetes is characterized in that it is made by following materials of weight proportions medicine:
Cortex Lycii 20-30g, Rhizoma Coptidis 5-9g, Ramulus Euonymi 20-30g, Fructus Corni 12-18g.
2. method for preparing the described Chinese medicine compound effective site of claim 1 is characterized in that preparation process is as follows:
(1) take by weighing Cortex Lycii 20-30g, Rhizoma Coptidis 5-9g, Ramulus Euonymi 20-30g, Fructus Corni 12-18g adds 5 times of water gagings of medical material amount, decocts to extract 1h, filters, and filtrate is continued to employ, and medicinal residues add 5 times of water gagings again, decoct to extract 1h again, filter, and merge filtrate twice, carry out concentrating under reduced pressure;
(2) with macroporous resin column enrichment on the above-mentioned concentrated solution, with the alcoholic solution eluting of 50-70%, collect eluent, decompression and solvent recovery is concentrated into and contains 3g crude drug/ml, must treat the Chinese medicine compound effective site of diabetes.
3. the application of Chinese medicine compound effective site as claimed in claim 1 in preparation treatment diabetes medicament.
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| Application Number | Priority Date | Filing Date | Title |
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| CN2009101832856A CN101623388B (en) | 2009-07-30 | 2009-07-30 | Active part of traditional Chinese medicine composite for curing diabetes and preparation method thereof |
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|---|---|---|---|
| CN2009101832856A CN101623388B (en) | 2009-07-30 | 2009-07-30 | Active part of traditional Chinese medicine composite for curing diabetes and preparation method thereof |
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| CN101623388A CN101623388A (en) | 2010-01-13 |
| CN101623388B true CN101623388B (en) | 2011-05-18 |
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| CN104147240A (en) * | 2014-07-10 | 2014-11-19 | 南京中医药大学 | Traditional Chinese medicine composition for killing bacteria and relieving pain as well as preparation method and application thereof |
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